|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
31-483 |
0e+00 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 662.59 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 31 MPQALER----ADGSWAWVVLLATMVTQGLTLGFPTCIGIFFTELQWEFQASNSETSWFPSILTAVLHMAGPLCSILVGR 106
Cdd:TIGR00892 1 MPPALPPegppPDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 107 FGCRVTVMLGGVLASLGMVASSFSHNLSQLYFTAGFITGLGMCFSFQSSITVLGFYFVRRRVLANALASMGVSLGITLWP 186
Cdd:TIGR00892 81 FGCRPVVIAGGLLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 187 LLSRYLLENLGWRGTFLVFGGIFLHCCICGAIIRPVATS---VAPETKECPPPPPETPALGClAACGRTIQRHLAFDILR 263
Cdd:TIGR00892 161 PLNQYLFESFGWRGSFLILGGLLLHCCVCGALMRPVGPSqrvSKSKSKEGLPPDGSTKKLSK-KSTAEKINRFLDFSLFT 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 264 HnTGYCVYILGVMWSVLGFPLPQVFLVPYAMWHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRPAFASHRKYLFSLALL 343
Cdd:TIGR00892 240 H-RGFLVYLSGNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGLKWIRPHVQYLFSFALL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 344 LNGLTNLVCAASGDFWVLVGYCLAYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATNN 423
Cdd:TIGR00892 319 FNGLTHLLCALAGDYTGLVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKN 398
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 424 FSYVFYMSSFFLISAALFMGGSFYALQKKEQGKQavaADALERDLFLEAKDGPGKQRSPE 483
Cdd:TIGR00892 399 YKYIFYASGSIVVSAGLFLAIGNYINYRLLAKEQ---KAALEREGARDKKDAEGDSRESE 455
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
43-446 |
0e+00 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 637.58 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 43 AWVVLLATMVTQGLTLGFPTCIGIFFTELQWEFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASL 122
Cdd:cd17425 1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 123 GMVASSFSHNLSQLYFTAGFITGLGMCFSFQSSITVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTF 202
Cdd:cd17425 81 GMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 203 LVFGGIFLHCCICGAIIRPvatsvapetkecpppppetpalgclaacgrtiqrhlafdiLRHNTGYCVYILGVMWSVLGF 282
Cdd:cd17425 161 LVFGGVLLNCCVCGAVMRP----------------------------------------FCSNTRYQIYTLGVTWMVLGF 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 283 PLPQVFLVPYAMWHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRPAFASHRKYLFSLALLLNGLTNLVCAASGDFWVLV 362
Cdd:cd17425 201 VLPLIYLVPYATSNGMDESKAALLLSILGFINIFMRPLAGLLSGLPVFKGRRIYLFSLALLLNGLSNLICAISASFPVLL 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 363 GYCLAYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFFLISAALFM 442
Cdd:cd17425 281 VYCLLYSISMSGIGSLIFQVLMDTVEMDRFPSALGLFTILESVTILIGPPLAGLLVDITQQYSYVFYASSIFVVSAALFM 360
|
....
gi 2462558660 443 GGSF 446
Cdd:cd17425 361 GLSF 364
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
43-445 |
9.87e-120 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 359.56 E-value: 9.87e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 43 AWVVLLATMVTQGLTLGFPTCIGIFFTELQWEFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASL 122
Cdd:cd17352 1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 123 GMVASSFSHNLSQLYFTAGFITGLGMCFSFQSSITVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTF 202
Cdd:cd17352 81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 203 LVFGGIFLHCCICGAIIRpvatsvapetkecpppppetpalgclaacgrtiqrhlafdiLRHNTGYCVYILGVMWSVLGF 282
Cdd:cd17352 161 LILGGLCLNLCVCGLLLR-----------------------------------------LLKDPTFVLLALGVSFAMLGF 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 283 PLPQVFLVPYAMWHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRPAFasHRKYLFSLALLLNGLTNLVCAASGDFWVLV 362
Cdd:cd17352 200 FVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRI--GRLYLYIFTLLILGLSLLAFPLATTYVGLI 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 363 GYCLAYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFFLISAALFM 442
Cdd:cd17352 278 VFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLL 357
|
...
gi 2462558660 443 GGS 445
Cdd:cd17352 358 FLL 360
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
43-442 |
4.76e-106 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 324.76 E-value: 4.76e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 43 AWVVLLATMVTQGLTLGFPTCIGIFFTELQWEFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASL 122
Cdd:cd17430 1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLASL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 123 GMVASSFSHNLSQLYFTAGFITGLGMCFSFQSSITVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTF 202
Cdd:cd17430 81 GMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGWRGGF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 203 LVFGGIFLHCCICGAIIRPvatsvapetkecpppppetpalgclaacgrtiqrhLAFDILRhNTGYCVYILGVMWSVLGF 282
Cdd:cd17430 161 LILGGLLLNCCTCGAVMRP-----------------------------------LDFSVFR-DRGFVIYTIAKFIMVLGL 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 283 PLPQVFLVPYAMWHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRPAFASHRKYLFSLALLLNGLTNLVCAASGDFWVLV 362
Cdd:cd17430 205 FVPPIFVVNYAKDIGVPDTEAAFLLSILGFIDIFARPACGVVAGLKWVRPRVVYLFSFAMLFNGLTDLCSATAADYGGLV 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 363 GYCLAYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFFLISAALFM 442
Cdd:cd17430 285 VFCVFFGISYGMVGALQFEVLMAIVGTQKFSSAIGLVLLVEAVAVLIGPPSAGRLVDATKNYELIFYLAGSEVVLSALFL 364
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
44-442 |
2.90e-79 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 255.51 E-value: 2.90e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 44 WVVLLATMVTQGLTLGFPTCIGIFFTELQWEFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASLG 123
Cdd:cd17427 2 WAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 124 MVASSFSHNLSQLYFTAGFITGLGMCFSFQSSITVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTFL 203
Cdd:cd17427 82 MISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGSFL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 204 VFGGIFLHCCICGAIIRPVATsvapetkecpppppetpalgclaacgrtiqrhlafdiLRHNTGYCVYILGVMWSVLGFP 283
Cdd:cd17427 162 ILGGLLLNCCVAGSLMRPLGP-------------------------------------LFKHRGFLIYLSGNVIMFLGFF 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 284 LPQVFLVPYAMWHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRPAFASHRKYLFSLALLLNGLTNLVCAASGDFWVLVG 363
Cdd:cd17427 205 APIVFLAPYAKHMGIDEYSAAFLLSILAFVDMFARPSMGLVANSKWIRPRIQYFFSFAVMYNGVCHLLCPLAEDYTGLVI 284
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462558660 364 YCLAYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFFLISAALFM 442
Cdd:cd17427 285 YAVFFGFAFGMVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVTGNYKYMYFVCGAIVIVASIWL 363
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
44-442 |
3.45e-67 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 223.99 E-value: 3.45e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 44 WVVLLATMVTQGLTLGFPTCIGIFFTELQWEFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASLG 123
Cdd:cd17426 2 WAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 124 MVASSFSHNLSQLYFTAGFITGLGMCFSFQSSITVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTFL 203
Cdd:cd17426 82 LIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRGSFL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 204 VFGGIFLHCCICGAIIRPVATsvapetkecpppppetpalgclaacgrtiQRHLAFDILRHNtGYCVYILGVMWSVLGFP 283
Cdd:cd17426 162 ILGGLLLNCCVAGSLMRPIGP-----------------------------KPFLDLTLFTHR-GFLLYLSGNVIMFFGLF 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 284 LPQVFLVPYAMWHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRPAFASHRKYLFSLALLLNGLTNLVCAASGDFWVLVG 363
Cdd:cd17426 212 APLVFLSNYAKSKQISNESAAFLLSILAFVDMVARPSMGIVANTKWVRPRIQYFFAASVLYNGVCHLLAPLSTSYVGFCI 291
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462558660 364 YCLAYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFFLISAALFM 442
Cdd:cd17426 292 YAIFFGFAFGWLSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLLGRLNDIYGDYKYTYWACGIVLIISSIYL 370
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
44-443 |
1.86e-62 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 210.76 E-value: 1.86e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 44 WVVLLATMVTQGLTLGFPTCIGIFFTELQWEFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASLG 123
Cdd:cd17422 2 WAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 124 MVASSFSHNLSQLYFTAGFITGLGMCFSFQSSITVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTFL 203
Cdd:cd17422 82 MITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 204 VFGGIFLHCCICGAIIRpvatsvapetkecpppppetpalgclaacgrtiqrhlafdILRhNTGYCVYILGVMWSVLGFP 283
Cdd:cd17422 162 VVGALQLNIVVCGALLR----------------------------------------VLK-EPGFICYALFGLFATLGFF 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 284 LPQVFLVPYAMWHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRPAFashRK-YLFSLALLLNGLTNLVCAASGDFWVLV 362
Cdd:cd17422 201 APQLYIIPLSLSLGIDQDWAAYMLSAMAIAELFGRISAGWVLNKCPI---RKiYIELICVILLCVVLLLFPFAYGFWSLL 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 363 GYCLAYSVSMSGIGALIFQVLM--DIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFFLISAAL 440
Cdd:cd17422 278 VCSIFYGFMFGTVAGTHIPLLAedDVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALGAV 357
|
...
gi 2462558660 441 FMG 443
Cdd:cd17422 358 FLA 360
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
44-440 |
2.23e-59 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 203.39 E-value: 2.23e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 44 WVVLLATMVTQGLTLGFPTCIGIFFTELQWEFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASLG 123
Cdd:cd17423 2 WVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 124 MVASSFSHNLSQLYFTAGFITGLGMCFSFQSSITVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTFL 203
Cdd:cd17423 82 FLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGALL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 204 VFGGIFLHCCICGAIIRPVATSvapetkecpppppetpalGCLAACGRTIQRHLAFDILRHNtGYCVYILGVMWSVLGFP 283
Cdd:cd17423 162 LLSALSLHLVPCGALLRPLALP------------------GDPPAPPRSLSAAFGLSLLTHR-AFLRYALATTLINTGYF 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 284 LPQVFLVPYAMWHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRPAFAShrKYLFSLALLLNGLTNLVCAASGDFWVLVG 363
Cdd:cd17423 223 IPYVHLVAHARALGLGEYQAAFVVSVAAVADAVGRLFSGWLADLGPLRL--LHLLVLWTALTGLSLLLLPLAKVYGSLLA 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462558660 364 YCLAYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFFLISAAL 440
Cdd:cd17423 301 LAVAYGFCAGALAPLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDYTASFLVAGSFLLLGSL 377
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
44-443 |
7.01e-52 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 182.70 E-value: 7.01e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 44 WVVLLATMVTQGLTLGFPTCIGIFFTELQWEFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASLG 123
Cdd:cd17424 2 WMIVAGCFLVTVCTRAVTRCISIFFVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLASTG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 124 MVASSFSHNLSQLYFTAGFITGLGMCFSFQSSITVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTFL 203
Cdd:cd17424 82 LILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 204 VFGGIFLHCCICGAIIRPVATSvapetkecpppppetpalgclaacgrtiqrhlafdilrhntGYCVYILGVMWSVLGFP 283
Cdd:cd17424 162 ILGGFVLNLCVCGALMRFLLMP-----------------------------------------DFLVLAVSVLFLAYGCS 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 284 LPQVFLVPYAMWHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRPAFASHRKYLFSLALLLNGLTNLVCAASGDFWVLVG 363
Cdd:cd17424 201 PPFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKKYRYFCYLFAVGMDGLCCLFLPILKTFPLLVP 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 364 YCLAYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFFLISAALFMG 443
Cdd:cd17424 281 FSFTFGYFDGAYVALIPVVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGTYTAAFLLSGFSMIFSSLLLG 360
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
43-442 |
2.28e-42 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 156.91 E-value: 2.28e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 43 AWVVLLATMVTQGLTLGFPTCIGIFFTELQWEFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASL 122
Cdd:cd17421 1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 123 GMVASSFSHNLSQLYFTAGFITGLGMCFSFQSSITVLGFYFVRRRVLANALASMGVSLGITLWPlLSRYLLENLGWRGTF 202
Cdd:cd17421 81 GFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGLTFALAP-FTQLLLDEYDWQGAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 203 LVFGGIFLHCCICGAIIRPVATSvapetkecpppppetpalgclaacgrtiqrhlafdiLRHNTGYCVYILGVMWSVLGF 282
Cdd:cd17421 160 LIFGGIMLNLVASGMLLRPIDFS------------------------------------LLKDPFFCIYTWSFVFSQLAY 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 283 PLPQVFLVPYAMWHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRPAFashRKYLFSLA-LLLNGLTNLVCAASGDFWVL 361
Cdd:cd17421 204 FIPYFHLVARARTLGIDPMDASFIISVAGITETVAQLASGWIADQNWI---KKYHYHKAyLILCGVTNLLAPLATTYPLL 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 362 VGYCLAYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSS--FFLISAA 439
Cdd:cd17421 281 MTYAVFFAIFCGGYLALLLPVLVDLVGVTKVNSSLGFSMFFAGIGCLTGPPLAGWLYDYTQTYDCSFYLAGgcYLLSSVS 360
|
...
gi 2462558660 440 LFM 442
Cdd:cd17421 361 FFL 363
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
43-442 |
1.31e-36 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 141.17 E-value: 1.31e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 43 AWVVLLATMVTQGLTLGFPTCIGIFFTELQWEFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASL 122
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 123 GMVASSFSHNLSQLyFTAGFITGLGMCFSFQSSITVLGFYFVRRRV-LANALASMGVSLGITLWPLLSRYLLENLGWRGT 201
Cdd:COG2223 83 GLLLLALAVSYWLL-LLLGLLLGIGGGGSFAVGIALVSKWFPPDRRgLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 202 FLVFGGIFLhccICGAIIRPVATSVApetkeCPPPPPETPALGCLAACGRTiqrhlafdilRHNTGYCVYILGVMWSVLG 281
Cdd:COG2223 162 FLILGILLL---VVAVLAWLFLRDPP-----AGAAAAAKASLRDQLEALRD----------PRFWLLSLLYFGTFGSFIG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 282 FplpQVFLVPYAM-WHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRpaFASHRKYLFSLALLLNGLTnLVCAASGDFWV 360
Cdd:COG2223 224 F---SSWLPPYLVdQFGLSAATAGLLAALFALLGALGRPLGGWLSDR--IGGRRVLLIVFALMALGLL-LLALALGSLWL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 361 LVGYCLAYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFFLISAAL 440
Cdd:COG2223 298 FLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALV 377
|
..
gi 2462558660 441 FM 442
Cdd:COG2223 378 LT 379
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
43-431 |
1.72e-36 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 141.13 E-value: 1.72e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 43 AWVVLLATMVTQGLTLGFPTCIGIFFTELQWEFQASN-----SETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGG 117
Cdd:cd17420 1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLTKLGdpeasFKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 118 VLASLGMVASSFSHNLSQLYFTAGFITGLGMCFSFQSSITVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLG 197
Cdd:cd17420 81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 198 WRGTFLVFGGIFLHCCICGAIIRPVATSVAPETKECPPPPPETPALGCLaacgrtiQRHLAFDILRHNTgYCVYILGVMW 277
Cdd:cd17420 161 LEGTLRVLSLFMFVLILCSFTYRPLHPSPEDPKSKPGRRTLHSRINLFL-------RKIFNVEIFKRKR-YVIWALGIPL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 278 SVLGFPLPQVFLVPYAMWHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRPAfASHRKYLFSLALLLNGLTNLVCAASGD 357
Cdd:cd17420 233 ALFGYFVPYVHLMKFVKEEFFPGKDVNVPLMCIGITSGIGRLIFGVIADMPP-GVKKMYLQVLSFVSIGLMSMMIPLCNS 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462558660 358 FWVLVGYCLAYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMS 431
Cdd:cd17420 312 FGILISVCLVMGLFDGCFISIMAPIAFELVGPSGASQAIGFLLGLMSIPMTVGPPIAGLLRDSTGSYTVAFYLA 385
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
43-442 |
4.15e-36 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 139.20 E-value: 4.15e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 43 AWVVLLATMVTQGLTLGFPTCIGIFFTELQWEFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASL 122
Cdd:cd17429 1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 123 GMVASSFSHNLSQLYFTAGFITGLGMCFSFQSSITVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTF 202
Cdd:cd17429 81 GWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 203 LVFGGIFLHCCICGAIIRpvatsvapetkecpppppetpalgclaacgrtiqrhlafdiLRHNTGYCVYILGVMWSVLGF 282
Cdd:cd17429 161 FIQGAVSLNLCVCGALMR-----------------------------------------LFTNKVFVAFIFWALFAYCSF 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 283 PLPQVFLVPYAMWHSVDEQQAAL-LISIIGFSNIFLRPLAGLMAGRPAFASHRkyLFSLALLLNGLTNLVCAASGDFWVL 361
Cdd:cd17429 200 VIPFIHLPEIVKLYGLSEQNDKFpLTSIIAIVHIFGKVILGIICDLPCISVWN--VFILANFTLGVCILILPLMHTYTGL 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 362 VGYCLAYSVSmSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFFLISAALF 441
Cdd:cd17429 278 AIVCALIGFS-SGYFSLMPVVTEDLVGIKNLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYVCGLLYMVGIIC 356
|
.
gi 2462558660 442 M 442
Cdd:cd17429 357 L 357
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
36-442 |
7.94e-33 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 129.60 E-value: 7.94e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 36 ERADGSWAWVVLLATMVTQGLTLGFPTCIGIFFTELQWEFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVML 115
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 116 GGVLASLGMVASSFSHNLSQLYFTAgFITGLGMCFSFQSSITVLGFYF-VRRRVLANALASMGVSLGITLWPLLSRYLLE 194
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFpPKERGRALGIFNAGGPLGGALAPPLLGWLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 195 NLGWRGTFLVFGgiflhccicgaiirpvatsvapetkecpppppetpALGCLAACGRTIqrhlafdilrhntGYCVYILG 274
Cdd:COG2271 160 AFGWRAAFLILG-----------------------------------LPGLLLALLRFW-------------LLALAYFL 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 275 VMWSVLGFplpQVFLVPYAM-WHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRpaFASHRKYLFSLALLLNGLTNLVCA 353
Cdd:COG2271 192 VYFALYGF---LTWLPTYLVeVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDR--LGRRRKLVLAIGLLLAALALLLLA 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 354 ASGDFWVLVGYCLAYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATnNFSYVFYMSSF 433
Cdd:COG2271 267 LLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT-GYQAAFLLLAA 345
|
....*....
gi 2462558660 434 FLISAALFM 442
Cdd:COG2271 346 LALLAALLA 354
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
44-442 |
1.18e-28 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 117.61 E-value: 1.18e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 44 WVVLLATMVTQGLTLGFPTCIGIFFTELQWEFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASLG 123
Cdd:cd17428 2 WVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAGG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 124 MVASSFSHNLSQLYFTAGFITGLGMCFSFQSSITVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTFL 203
Cdd:cd17428 82 LMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 204 VFGGIFLHCCICGAIIRPVATSVApetkecpppppetpalgclaacgrtiqrhlafdilrhnTGYCVYILgvMWSVLGFP 283
Cdd:cd17428 162 IVGALALNLLACGSLMRLFKNRVF--------------------------------------SALFIAIL--LFDIGAFP 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 284 lPQVFLVPYAMWHSVDEQQAAL-LISIIGFSNIFLRPLAGLMAGRPAFAShrKYLFSLALLLNGLTNLVCAASGDFWVLV 362
Cdd:cd17428 202 -PSLLMEDVARSENIIEEIALIpLVSIIGITTAIGKLILGVLADFKWVNS--LYLYVLTLIGMGAALLAIPFAKSYLTLA 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 363 GYCLAYSVsMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFFLISAALFM 442
Cdd:cd17428 279 VLSAILGF-LSGNWSIFPYVTTKTVGIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFLL 357
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
44-431 |
1.68e-27 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 114.89 E-value: 1.68e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 44 WVVLLATMVTQGLTLGFPTCIGIFFTELQWEFQASNSE-----TSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGV 118
Cdd:cd17464 2 WVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFGSKDDAqmrfkTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 119 LASLGMVASSFSHNLSQLYFTAGFITGLGMCFSFQSSITVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGW 198
Cdd:cd17464 82 VGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVGL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 199 RGTFLVFGGIFLHCCICGAIIRPVATSVAPETKECPPPPPEtpalgclaacgrTIQRHLAFDILRhNTGYCVYILGVMWS 278
Cdd:cd17464 162 FNTLRVLCIFMFVLFLAGFTYKPLVPMKKDKEGKKRKFKCP------------PLKKIFNFNIWK-STGYRIWAFGIPAA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 279 VLGFPLPQVFLVPYAMWHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRPAfASHRKYLFSLALLLNGLTNLVCAASGDF 358
Cdd:cd17464 229 LFGYFVPYVHLMNHVKERFGEDVNKEVLLMCIGITSGIGRLIFGRVADYIP-GVKKVYLQVSSFFFIGLMSMMIPLCHVF 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462558660 359 WVLVGYCLAYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMS 431
Cdd:cd17464 308 GGLIAVCLFMGLFDGCFISIMAPIAFELVGAQNVSQAIGFLLGLMSIPMTVGPPIAGFLRDRLGSYDVAFYLA 380
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
43-440 |
7.64e-27 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 112.75 E-value: 7.64e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 43 AWVVLLATMVTQGLTLGFPTCIGIFFTELQWEFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASL 122
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 123 GMVASSFSHNLSQLYFTAGFITGLGM-CFSFQSSITVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGT 201
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGGAgTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 202 FLVFGGiflhccICGAIIRPVATSVAPETKECPPPPPETPALGCLAACGRTIQRHLAFDILRHNTGYCVYILGVMwsvlg 281
Cdd:cd17355 161 LLVLAL------LALLVLVPVLLLLRRRPADLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGL----- 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 282 fplpQVFLVPYAMWHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRpafaSHRKYLFSLALLLNGLTNLVCAASG-DFWV 360
Cdd:cd17355 230 ----IVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDR----YSPRRLLAASYALRALGLALLLLLPfPPLA 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 361 LVGYCLAYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFFLISAAL 440
Cdd:cd17355 302 LLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAAL 381
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
44-442 |
9.35e-25 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 106.42 E-value: 9.35e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 44 WVVLLATMVTQGLTLGFPTCIGIFFTELQWEF-----QASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGV 118
Cdd:cd17465 2 WVVVFAATWCNGSIFGIQNSFGILYVMLLNEQedqkdQAVQFKTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGGAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 119 LASLGMVASSFSHNLSQLYFTAGFITGLGMCFSFQSSITVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGW 198
Cdd:cd17465 82 VAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLLKMVGDAIGL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 199 RGTFLVFGGIFLhccicgaiirpvatsvapetkecpppppetpalgclaacgRTIQRHLAFDILRHNTgYCVYILGVMWS 278
Cdd:cd17465 162 AHTFQVLSLFMF----------------------------------------IQIFLSLTYKVFRRKT-YRIWAFGIATA 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 279 VLGFPLPQVFLVPYAMWHSVDEQQAALLISIIGFSNIFLRPLAGLMaGRPAFASHRKYLFSLALLLNGLTNLVCAASGDF 358
Cdd:cd17465 201 VLGYFVPYVHLMKYVEEEFKENKREWVLLVCIGASSGIGRLMSGKI-GDLIPGLKKIYLQVASFLLLGIMSMMIPLCQVF 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 359 WVLVGYCLAYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFFLISA 438
Cdd:cd17465 280 EGVIVVCLFLGLCDGCFITIMAPIAFELVGPMQASQAIGYLLGLMAIPMTAGPPIAGLLHDYFGSYHVAFYLAGVPPIIG 359
|
....
gi 2462558660 439 ALFM 442
Cdd:cd17465 360 GTVL 363
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
64-441 |
5.63e-24 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 104.05 E-value: 5.63e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 64 IGIFFTELQWEFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASLGMVASSFSHNLSQLYFtAGFI 143
Cdd:cd06174 15 ISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLL-GRFL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 144 TGLGMCFSFQSSITVLGFYFV-RRRVLANALASMGVSLGITLWPLLSRYLLENL--GWRGTFLVFGGIFLHCCICGAIIR 220
Cdd:cd06174 94 LGLGSGLIDPAVLALIADLFPeRERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAAALALLAAILLLLVV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 221 PvatsvapetkECPPPPPETPALGCLAACGRTIQRHLAFDILRhntgyCVYILGVMWSVLGFPLPQVFLVPYAMWHSVDE 300
Cdd:cd06174 174 P----------DPPESARAKNEEASSKSVLKLLKRVLKNPGLW-----LLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 301 QQAALLISIIGFSNIFLRPLAGLMAGRPafaSHRKYLFSLALLLNGLTNLVCAASGDFWVLVGYCLAYSVSMSGIGALIF 380
Cdd:cd06174 239 AVAGLLLSLFGLAGALGSLLLGLLSDRL---IGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSF 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462558660 381 QVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFFLISAALF 441
Cdd:cd06174 316 ALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAIL 376
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
32-441 |
8.89e-24 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 103.80 E-value: 8.89e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 32 PQALERADGSWAWVVLLATMVTQGLTLGFP-TCIGIFFTELQWEFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCR 110
Cdd:COG2807 4 TSSSARRSRRAGRWLLLLAIVLVALNLRPAiTSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 111 VTVMLGGVLASLGMVASSFSHNLSQLYFTAGFItGLGMCFSFQSSITVLGFYFVRRRVLANALASMGVSLGITLWPLLSR 190
Cdd:COG2807 84 RTLLLALLLLAAGLLLRSLAPSVALLLAGTALI-GAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 191 YLLENLGWRGTFLVFGGIflhCCICGAIIRPVATSVApetkecpppppetpalgclAACGRTIQRHLAFDILRHNTGYCV 270
Cdd:COG2807 163 PLAAALGWRGALAVWALL---ALLALLLWLPLLRRRP-------------------AAAAAAPAAASLRSLWRSPLAWLL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 271 YILGVMWSVLGFpLPQVFLVPYAMWHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRpaFASHRKYLFSLALLlnGLTNL 350
Cdd:COG2807 221 TLFFGLQSLLYY-AVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADR--LGDRRPLLLLLGLL--GLAGL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 351 VCAASGDFWVLVGYCLAYSVSMSGIGALIFQVLMDIVPM-DQFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFY 429
Cdd:COG2807 296 LGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTpAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALL 375
|
410
....*....|..
gi 2462558660 430 MSSFFLISAALF 441
Cdd:COG2807 376 LLAALAVLMLVA 387
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
38-406 |
8.73e-23 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 100.05 E-value: 8.73e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 38 ADGSWAWVVLLATMVTQGLTLGFPTCIGIFFTELQWEFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGG 117
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 118 VLASLGMVASSFSHNLSQLYFtAGFITGLGMCFSFQSSITVLGFYF-VRRRVLANALASMGVSLGITLWPLLSRYLLENL 196
Cdd:COG2814 83 LLFALGSLLCALAPSLWLLLA-ARFLQGLGAGALFPAALALIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 197 GWRGTFLVFGGIFLHCCICGAIIRPVATSVApetkecpppppetpalgclaacgRTIQRHLAFDILRHNTGYCVYILGVM 276
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLLPESRPAA-----------------------RARLRGSLRELLRRPRLLLLLLLAFL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 277 WSVLGFPLpQVFLVPYAM-WHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRpafaSHRKYLFSLALLLNGLTNLVCAAS 355
Cdd:COG2814 219 LGFGFFAL-FTYLPLYLQeVLGLSASAAGLLLALFGLGGVLGALLAGRLADR----FGRRRLLLIGLLLLALGLLLLALA 293
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 2462558660 356 GDFWVLVGYCLAYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGLA 406
Cdd:COG2814 294 GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
74-411 |
2.93e-21 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 95.56 E-value: 2.93e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 74 EFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASLGMVASSFSHNLSQLYFtAGFITGLGMCFSFQ 153
Cdd:pfam07690 26 DLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLV-LRVLQGLGAGALFP 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 154 SSITVLGFYF-VRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTFLVFGGIFLHCCICGAIIRPVATSVAPetke 232
Cdd:pfam07690 105 AALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRP---- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 233 cpppppetpalgcLAACGRTIQRHLAFDILRHNTGYCVYILGVMWSvLGFPLPQVFLVPYAMWHSVDEQQAALLISIIGF 312
Cdd:pfam07690 181 -------------KPAEEARLSLIVAWKALLRDPVLWLLLALLLFG-FAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 313 SNIFLRPLAGLMAGRPAFAShRKYLFSLALLLNGLTNLVCAASGDFWVLVGYCLAYSVSMSGIGALIFQVLMDIVPMDQF 392
Cdd:pfam07690 247 LGAIGRLLLGRLSDRLGRRR-RLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEER 325
|
330
....*....|....*....
gi 2462558660 393 PRALGLFTVLDGLAFLISP 411
Cdd:pfam07690 326 GTASGLYNTAGSLGGALGP 344
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
43-440 |
1.09e-20 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 94.60 E-value: 1.09e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 43 AWVVLLATMVTQgLTLGFPTCIGIFFTELQWEFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASL 122
Cdd:cd17353 2 RWLVLLGAVLMH-LILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 123 GMVASSFSHNLSQLYFTAGFITGLGMCFSFQSSITVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTF 202
Cdd:cd17353 81 GFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 203 LVFGGIFL-HCCICGAIIRPVATSVAPETKECPPPppetpalgclAACGRTIQRHLAfDILRHNTGYCVYI---LGVMWS 278
Cdd:cd17353 161 LILGIIFLiIIVIGAFLIRDPPKGWVPPGVDPLAN----------NAENSPRDYTPR-EMLRTPTFWLLWLmffLNATAG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 279 VLGFplpqVFLVPYAM-WHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRPAfashRKYLFSLALLLNGLTNLVCAASGD 357
Cdd:cd17353 230 LMLI----GQAKPIGQeFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIG----RKNTLSIAFLIQGVAMFLLPFIGS 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 358 fwVLVGYCLAYSVSMSGIG---ALIFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGlLLDATNNFSYVFY-MSSF 433
Cdd:cd17353 302 --VAVLFVLGVALIGFCYGggfALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAA-YVLYTGGYNAAFIiAAAL 378
|
....*..
gi 2462558660 434 FLISAAL 440
Cdd:cd17353 379 SLVALAL 385
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
44-434 |
3.68e-20 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 92.86 E-value: 3.68e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 44 WVVLLATMVTQGLTLGFPTCIGIFFTELQWEFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASLG 123
Cdd:cd17314 2 WFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 124 MVASSFSHNLSQLYFTAGFITGLGMCFSFQSSITVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTFL 203
Cdd:cd17314 82 YTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYT 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 204 VFGGIFLHCCICGAIIRPVATSVAPETKEcpppppetpalgclaacgrtIQRHLAFDILRHNTGYCVYILGV-MWSVL-G 281
Cdd:cd17314 162 ILGILAAIVLSVVSLLGFKEPPDNQARLH--------------------VQKKKTQTMGEIFRDKVFWILFIaIFLVLiG 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 282 FPLPQVFLVPYAMWHSVDEQQ-AALLISIIGFSNIFLRPLAGLMAGrpaFASHRKYLFSLALLLNGLT---NLVCAASGD 357
Cdd:cd17314 222 GFLFIANMASLVRSLQLDAPSfVTKLMSIYGLFNAFGRLLWGIVAD---FFGGRLSTLSILLTILGLGlcaFLFLLKMTP 298
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462558660 358 FWVLVGYCLAYsVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFF 434
Cdd:cd17314 299 VGLVLTGSLLG-FSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVI 374
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
44-442 |
6.64e-16 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 79.93 E-value: 6.64e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 44 WVVLLATMVTQGLTLGFptcIGIFFTELQwefqASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASLG 123
Cdd:cd17325 2 SLALFLDMLGYGIIIPI---LPLYAESLG----ASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVS 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 124 MVASSFSHNLSQLYFTAgFITGLGMCFSFQSSITVLG-FYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTF 202
Cdd:cd17325 75 TLLFAFATSYWQLLLAR-FLQGLASAAVWPAAMALIAdIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPF 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 203 LVFGGIFLHCCICGAIIRPVATSVAPETKECPPPPPETPALgclaacgrtiqrhlafdiLRHNTGYCVYILGVMWSVLGF 282
Cdd:cd17325 154 LVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRL------------------LLRDRRLLALFLAIFVLAFAF 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 283 PLPQVFLVPYAMWH-SVDEQQAALLISIIGFSNIFLRPLAGLMAGRPAfashRKYLFSLALLLNGLTNLVCAASGDFWVL 361
Cdd:cd17325 216 GALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIG----RKPLILIGLLLSAVALLLLPLATSFWLL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 362 VGYCLAYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDaTNNFSYVFYMSSFFLISAALF 441
Cdd:cd17325 292 LLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD-AFGFATPFLAAAALLLLAAVL 370
|
.
gi 2462558660 442 M 442
Cdd:cd17325 371 F 371
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
62-440 |
1.18e-13 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 72.60 E-value: 1.18e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 62 TCIGIFFTELQWEFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASLGMVASSFSHNLSQLYFtAG 141
Cdd:cd17319 20 VNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYV-LR 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 142 FITGLGMCFSFQSSITVLGFYF-VRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTFLVFGgiflhccicgaiir 220
Cdd:cd17319 99 FLLGVAEAGFFPGAIKALAEWFpARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEG-------------- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 221 pvatsvapetkecpppppetpALGCLAACgrtiqrhLAFDILRHNTGYCVYILGVMWSVLGFP--LPQVFLVPYAMwhsv 298
Cdd:cd17319 165 ---------------------LLGLLLAV-------LWWFYLRQVWGLALGYFGINYALYGLLtwLPTYLKQARGF---- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 299 DEQQAALLISIIGFSNIFLRPLAGLMAGRPAFASHRKYLFsLALLLNGLTNLVCAASGDFWVLVGYCLAYSVSMSGIGAL 378
Cdd:cd17319 213 SLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVII-IGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPV 291
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462558660 379 IFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFFLISAAL 440
Cdd:cd17319 292 FWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAAL 353
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
272-442 |
1.86e-12 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 68.85 E-value: 1.86e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 272 ILGVMWSVLGFPLPQVFLVPYAMWHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRpafaSHRKYLFSLALLLNGLTNLV 351
Cdd:COG2814 16 ALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADR----FGRRRVLLLGLLLFALGSLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 352 CAASGDFWVLVGYCLAYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATnNFSYVFYMS 431
Cdd:COG2814 92 CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF-GWRWVFLVN 170
|
170
....*....|.
gi 2462558660 432 SFFLISAALFM 442
Cdd:COG2814 171 AVLALLALLLL 181
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
71-442 |
5.85e-12 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 67.65 E-value: 5.85e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 71 LQWEFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASLGMVASSFSHNLSQLYftaGFITGLGMCF 150
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLL---VLLFLVGAGY 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 151 S-FQSSIT--VLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTFLVFGGIflhcCICGAII-------R 220
Cdd:cd17475 99 GsVQPGGGraIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLV----SILAAVLfwlfyreP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 221 PVATSVAPETKECPppppetpalgclaacgRTIQRHLAFDILRHntgycvyilgVMWSVLGFPLPQVFLVPYAM-----W 295
Cdd:cd17475 175 PAASAATESASTLL----------------RSLKEVLRNRDVWL----------IAIAGALLVAPQFALLTFLLlflhdH 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 296 HSVDEQQAALLISIIGFSNIFLRPLAGLMAGRPAFASHRKYLFSLALL--LNGLTNLVCAASGDFWVLVGYCLAYSVSMS 373
Cdd:cd17475 229 LGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGGRRRPVLVITAAIaaAALLVLSLLSPGTPLWLLVLLLILLGLFAI 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462558660 374 GIGALIFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFFLISAALFM 442
Cdd:cd17475 309 GWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLL 377
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
85-442 |
1.34e-11 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 66.44 E-value: 1.34e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 85 FPSILTAVLhmaGPLCSILVGRFGCRVTVMLGGVLASLGMVASSFSHNLSQLYFTAgFITGLGMCFSFQSSITVLGFYFV 164
Cdd:cd17473 43 LPALFIALF---APLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASR-ALLGIGVAGIMTLATALIGDYFE 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 165 ---RRRVLAnaLASMGVSLGITLWPLLSRYLLEnLGWRGTFLVFG-GIFLHCCICGAIIRPVATSVAPetkecpppppet 240
Cdd:cd17473 119 geeRAKMLG--LQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYLlALPVLILVLLFLPEPARKSKSA------------ 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 241 palgclaacGRTIQRHLAFDILRHNTGYCVYILGVMwsvLGFPLPQVFLvPYAMWH--SVDEQQAALLISIIGFSNiflr 318
Cdd:cd17473 184 ---------ASPGAATAAALPWKRVLPIYFLAFLAM---LLFYVIPIQL-PFLLQErgGGSAALIGLALAIASLAG---- 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 319 PLAGLMAGRPAFASHRKYLFSLALLLNGLTNLVCAASGDFWVLVGYCLAYSVSMSGIGALIFQVLMDIVPMDQFPRALGL 398
Cdd:cd17473 247 AIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGI 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 2462558660 399 FTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFFLISAALFM 442
Cdd:cd17473 327 VTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVL 370
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
56-441 |
1.04e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 60.64 E-value: 1.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 56 LTLGFPTCI-GIFFTELQWEFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASLGMVASSFSHNLS 134
Cdd:COG0738 18 FLWGFATALwGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYP 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 135 qLYFTAGFITGLGMCFsFQSSITVLGFYFVRRRVlANALASMGV--SLGITLWPLLSRYLL---ENLGWRGTFLVFGGIF 209
Cdd:COG0738 98 -LLLLALFLLGLGLGL-LDVAANPYVAALGPETA-ASRLNLLHAffSLGALLGPLLGGLLIllgLSLSWHLPYLILAVLL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 210 LHCCICGAIIR------PVATSVAPETKECPPPPPETPALGCLAACGrtiqrhlafdilrhntgyCVYILGVMWSvlgfp 283
Cdd:COG0738 175 LLLALLFLRSKlpeieeEEEEAAGSAASLKSLLKNPRLLLGGLAIFL------------------YVGAEGAIGD----- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 284 lpqvFLVPYAM-WHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRpaFASHRkyLFSLALLLNGLTNLVCAASGDFWVLV 362
Cdd:COG0738 232 ----WLPLYLKdVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKR--FGPVR--LLRLSALLAAVGLLLALLAPGPWLAL 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462558660 363 GYCLAYSVSMSGIGALIFQVLMDIVPMDQfPRALGLFTVLDGLAFLISPPLAGLLLDATnNFSYVFYMSSFFLISAALF 441
Cdd:COG0738 304 IGLALVGLGLSLMFPTIFSLALDGLGKRT-AAAVSAVLIMGIVGGAIGPPLIGFLADAF-GLRAAFLVPLVCYLLILLL 380
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
34-326 |
1.47e-09 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 59.44 E-value: 1.47e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 34 ALERADGSWAWVVLLATMVTQGLTLGFPTCIGIFFTELQWEFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTV 113
Cdd:COG0477 3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 114 MLGGVLASLGMVASSFSHNLSQLYFtAGFITGLGMCFSFQSSITVLGFYF-VRRRVLANALASMGVSLGITLWPLLSRYL 192
Cdd:COG0477 83 LIGLLLFGLASLLCGLAPSPELLIA-ARALQGIGAGGLMPGALALIAELFpARERGRALGLWGAAIGLGLALGPLLGGLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 193 LENLGWRGTFLVFGGIFLhccICGAIIRPVATSVAPETKECPPPPPETPALGCLAACGRTIQRHLAFDILRHNTGYCVYI 272
Cdd:COG0477 162 VAALGWRWIFLINAPLGL---LALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAA 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 2462558660 273 LGVMWSVLGFPLPQVFLVPYAMWHSVDEQQAALLISIIGFSNIFLRPLAGLMAG 326
Cdd:COG0477 239 LLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLA 292
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
113-441 |
3.39e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 59.17 E-value: 3.39e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 113 VMLGGVLASLGMVASSFSHNLSQLYFTAgFITGLGMCF---SFQSSITVLgfyfVRRRVL--ANALASMGVSLGITLWPL 187
Cdd:cd06173 72 LLRALLAAVLALLALLGSLSLWLLLVLA-FLLGIASAFfgpARQALLPEL----VPKEQLvrANALNSLATQLARIIGPA 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 188 LSRYLLENLGWRGTFLVFGGIFLHCCICGAIIRPVATSVAPETKECPPPPPetpalgclaacgrtiqRHLAFDILRHNTG 267
Cdd:cd06173 147 LGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDL----------------REGLRYLRRSPLL 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 268 YCVYILGVMWSVLGFPLpQVFLVPYA-MWHSVDEQQAALLISIIGFSNIflrpLAGLMAGRPAFASHRKYLFSLALLLNG 346
Cdd:cd06173 211 RLLLLALALFALLGGAL-TVLLPLLAkEVLGGGAAGYGLLLAAFGVGAL----LGALLLGRLSKRRRRGRLLLIGALLLG 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 347 LTNLVCAASGDFWVLVGYCLAYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATnNFSY 426
Cdd:cd06173 286 LALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAL-GLSA 364
|
330
....*....|....*
gi 2462558660 427 VFYMSSFFLISAALF 441
Cdd:cd06173 365 VFLLAGALLLLAALL 379
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
74-442 |
5.39e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 58.37 E-value: 5.39e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 74 EFQASNSE----TSWFpsILTAVLhmAGPLCSILVGRFGCRVTVMLGGVLASLGMVASSFSHNLSqLYFTAGFITGLGMC 149
Cdd:cd17489 25 DLGGSEAVaglvVGLF--TLAALL--ARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA-LLLVLRLIHGIGWG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 150 FSFQSSITVLGFYF-VRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTFLVFGGIFLHCCICGAIIRPVATSVap 228
Cdd:cd17489 100 AFTTAAATLVADIIpPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVA-- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 229 etkecpppppetpalgclAACGRTIQRHLAFDILRHNTGYCvyiLGVMWSVLGFPLPQVFLVPYAMWHSVDeqQAALLIS 308
Cdd:cd17489 178 ------------------AEEAEAGTRAFRRLVEKKVLPPA---LILFLASIAYGAISTFLPLYAAERGIS--NAGLFFT 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 309 IIGFSNIFLRPLAGLMAGRPafasHRKYLFSLALLLNGLTNLVCAASGDFWVLVG----YCLAYSVSMSGIGALIFQVlm 384
Cdd:cd17489 235 VYAIALLLSRPFSGKLSDRK----GPKTVIIPGLLLLALGLLLLSFAGSPWMLLLaavlYGLGFGLLFPALQALAVDL-- 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 2462558660 385 diVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATnNFSYVFYMSSFFLISAALFM 442
Cdd:cd17489 309 --VPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELF-GYRAMFLLAAVVVLLALVLY 363
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
99-442 |
1.43e-08 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 56.93 E-value: 1.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 99 LCSILVGRFGCRVTVMLGGVLASLGMVASSFSHN---LSQLYFTAGFITGLGMCFSfqsSITVLGFYFVRRRVLANALAS 175
Cdd:cd06180 53 LASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGfaaLLALRFLAGAASAFVFVFG---SNLVLHHATAAGRGHLIGLLF 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 176 MGVSLGITLWPLL-SRYLLENLGWRGTFLVFGGIFLHCCICGAIIRPvatsvapetkecppppPETPALGCLAACGRTIQ 254
Cdd:cd06180 130 AGVGLGIALSGLLvPAGLGGGLSWRAGWLALALLSAVLLLLSFLLLR----------------RGPSAPTEASAAESAPG 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 255 RHLAFDILrhntgycvyILGVMWSVLGFPLPQVFLVPYAMWHSVDEQQAALLISIIGFSNIFlrplAGLMAGRPAFASHR 334
Cdd:cd06180 194 LNRPLWRL---------ALAYGLFGFGYIITATFLPLIARETGAGSLLAGLLWSLFGLAAVP----SCFLWGALSDRWGT 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 335 KYLFSLALLLNGLTNLVCAASGDFWVLVGYCLAYSVSMSGIGALIFQVLMDIVPMDQfPRALGLFTVLDGLAFLISPPLA 414
Cdd:cd06180 261 RRALAANLLVQAVGVLLPLLSPGPAGLVLSAVLFGGTFMAITALVMALARELAPPAA-PRALALMTASFGVGQILGPLLA 339
|
330 340
....*....|....*....|....*...
gi 2462558660 415 GLLLDATNNFSYVFYMSSFFLISAALFM 442
Cdd:cd06180 340 GWLADATGGFAPALILAAAALVVAALLA 367
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
272-442 |
1.47e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 57.04 E-value: 1.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 272 ILGVMWSVLGFPLPQVFLVPYamwhSVDEQQAALLISIIGFSNIFLRPLAGLMAGRpafaSHRKYLFSLALLLNGLTNLV 351
Cdd:pfam07690 7 LAALGRSLLGPALPLLLAEDL----GISPTEIGLLLTLFSLGYALAQPLAGRLSDR----FGRRRVLLIGLLLFALGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 352 CAASGDFWVLVGYCLAYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATnNFSYVFYMS 431
Cdd:pfam07690 79 LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF-GWRAAFLIL 157
|
170
....*....|.
gi 2462558660 432 SFFLISAALFM 442
Cdd:pfam07690 158 AILSLLAAVLL 168
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
74-442 |
2.13e-08 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 56.40 E-value: 2.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 74 EFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGcRVTVMLGGV-LASLGMVASSFSHNLSQLyFTAGFITGLGMCFSF 152
Cdd:cd17324 28 DFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIE-RRRLLLVLLlLFILGNLLAALAPSFALL-LLARALAGLAHGGFW 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 153 QSSITVLGFYFV-RRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTFLVFGGIFLhcCICGAIIRPVATSVAPETK 231
Cdd:cd17324 106 AIAAAYAADLVPpEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLAL--LAALLLWRLLPSLPPKKPG 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 232 ECPPPPPETPALGclaacgrtiQRHLAFDILrhnTGYCVYI-LGVMWSVLGFPLPQVFLVPYamwhsvdeQQAALLISII 310
Cdd:cd17324 184 SLGLLSSLLLLLR---------NPRLRLAYL---ITFLLFGgFFALYTYLAPFLTDVPGFSS--------SAIIGLLLLF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 311 GFSNIFLRPLAGLMAGRpafaSHRKYLFSLALLLNGLTNLVCAASGDFWVLVGYCLAYSVSMSGIGALIFQVLMDIVPmD 390
Cdd:cd17324 244 GVAGVVGSPLAGRLADR----GGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-E 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 2462558660 391 QFPRALGLFTVLDGLAFLISPPLAGLLLDATnNFSYVFYMSSFFLISAALFM 442
Cdd:cd17324 319 ARGLASSLYLAAYNLGGALGAALGGLVLDHG-GWAGVGWVGAALLLLALLLA 369
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
96-441 |
1.05e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 54.49 E-value: 1.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 96 AGPLCSILVGRFGCRVTVMLGGVLASLGMVASSFSHNLSqLYFTAGFITGLGMCFSF---QSSITVLGFYFVRRRVLAna 172
Cdd:cd17477 47 GSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPW-VWFLLRFVMGIGLAGLFvvsESWLNALATNENRGRVLG-- 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 173 LASMGVSLGITLWPLLSRYLLENlGWRgTFLVFGGIFLHCCICGAIIR---PVATSVAPETKECPPPPPETPALGCLAAC 249
Cdd:cd17477 124 LYSTVLGLGFALGPLLLALVGTA-GAL-PFLIAAVLLLLALVPLLLTRraaPEIEEAESISLRRLLRIAPLALLGAFVAG 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 250 grtiqrhlafdilrhntgycvYILGVMWSvlgfplpqvFLVPYAMWHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRpa 329
Cdd:cd17477 202 ---------------------FLEGAFYS---------LLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADR-- 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 330 fASHRKYLFSLALLLNGLTNLVCAASGDFWVLVGYCLAYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGLAFLI 409
Cdd:cd17477 250 -FDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVI 328
|
330 340 350
....*....|....*....|....*....|..
gi 2462558660 410 SPPLAGLLLDATNNFSYVFYMSSFFLISAALF 441
Cdd:cd17477 329 GPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
105-449 |
1.29e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 54.52 E-value: 1.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 105 GRFgcRVTVMLGGVLASLGMVASSFSHNLSQ----LYFTAGFItGLGMCFS-----FQSSITVLGFYFVRRRVLA---NA 172
Cdd:COG2211 78 GRR--RPWILIGAIPLALSFVLLFTAPDLSPtgklIYALVTYL-LLGLAYTlvnipYSALGAELTPDYEERTRLSswrFA 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 173 LASMGVSLGITLWPLLSRYLLEN--LGWRGTFLVFGGIFLHCC-ICGAIIRPVATSVAPETKECPppppetpalgclaac 249
Cdd:COG2211 155 FAGLGGLLASVLPPPLVAAFGGDaaLGYRLTALIFAVLGLLAFlLTFFGTKERPVPEEEKVSLKE--------------- 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 250 grtiqrhlAFDILRHNTGYCVYILGVMWSVLGFPLPQVFLVPYAMWH-SVDEQQAALLISIIGFSNIFLRPLAGLMAGRp 328
Cdd:COG2211 220 --------SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLALYFLAALLGAPLWPRLAKR- 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 329 afaSHRKYLFSLALLLNGLTNLVCAASG--DFWVLVGYCLAYSVSMSGIGALIFQVLMDIVPMDQFPR-------ALGLF 399
Cdd:COG2211 291 ---FGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTgrrreglYFGIF 367
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 2462558660 400 TVLDGLAFLISPPLAGLLLDAT-------NNFSYVFYMSSFFLISAALFMGGSFYAL 449
Cdd:COG2211 368 TFAIKLGQALAGALAGLLLALFgyvagaaQSPSALTGIRLLFFLLPAVLLLLAALLL 424
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
68-220 |
1.74e-07 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 53.73 E-value: 1.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 68 FTELQWEFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASLGMVASSFSHNLSQLYF---TAGFIT 144
Cdd:cd17503 19 LPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIfriLQGFGG 98
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462558660 145 GLGMCFSFQSSITVlgfYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTFLVFGGIFLHCCICGAIIR 220
Cdd:cd17503 99 GVLIPLAQTILLRI---YPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPLLD 171
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
75-440 |
1.92e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 53.37 E-value: 1.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 75 FQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASLGMVASSFSHNLSQLyFTAGFITGLGMCFSFQS 154
Cdd:cd17316 31 LGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILL-LVLRFLQGIGIGGEYPG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 155 SITVLG-FYFVRRRVLANALASMGVSLGITL----WPLLSRYLLENLGWRGTFLVfGGIFlhcCICGAIIRPvatsvape 229
Cdd:cd17316 110 ASTYVAeFAPSKRRGFALGLLQSGWALGALLaalvASLLIPLLSGDWGWRILFLI-GALP---ALLALLLRR-------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 230 tkecpppppetpalgclaacgRTIqrhlafdilrhntgycVYILGVMWSVLGFPLPQVFLVPY-AMWHSVDEQQAALLIS 308
Cdd:cd17316 178 ---------------------RTL----------------LLILLWFFISFGYYGLTTFLPTYlQTVLGLSPATSSLYLL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 309 IIGFSNIFLRPLAGLMAGRpaFASHRKYLFSLALLLNGLTNLVCAASGDFWVLVGYCLAYSVSMSGIGALIFQVLMDIVP 388
Cdd:cd17316 221 LISLGALVGALIAGLLSDR--IGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFP 298
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 2462558660 389 MDQFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFFLISAAL 440
Cdd:cd17316 299 TEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALI 350
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
106-207 |
1.93e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 50.28 E-value: 1.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 106 RFGCRVTVMLGGVLASLGMVASSFSHNLSQLYFtAGFITGLGMCFSFQSSITVLGFYF-VRRRVLANALASMGVSLGITL 184
Cdd:cd17365 60 RFGRKRVLLVSVALFGLFTLLTAFAQSVLQLAL-LRFLTGLGLGAAMPNAITLVSEYApARRRSLAVTLMFCGYPLGAAL 138
|
90 100
....*....|....*....|...
gi 2462558660 185 WPLLSRYLLENLGWRGTFLVFGG 207
Cdd:cd17365 139 GGFLAAALIPAFGWRSVFLLGGV 161
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
44-221 |
2.33e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 50.25 E-value: 2.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 44 WVVLLATMVTQGLTLGFPTCIGIFFTElqwEFQASNSETSWFPSILTAVLHMAGPLCSILVGRFG--CRVTVMLGGVLAS 121
Cdd:COG2271 183 WLLALAYFLVYFALYGFLTWLPTYLVE---VRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 122 LGMVASSFSHNLsQLYFTAGFITGLGMCFSFQSSITVLGFYFVRRRV-LANALASMGVSLGITLWPLLSRYLLENLGWRG 200
Cdd:COG2271 260 LALLLLALLPSP-ALAIALLFLAGFGLGGAFGLLWALAAELFPKKARgTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338
|
170 180
....*....|....*....|.
gi 2462558660 201 TFLVFGGIFLHCCICGAIIRP 221
Cdd:COG2271 339 AFLLLAALALLAALLALLLLR 359
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
96-221 |
3.48e-06 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 46.87 E-value: 3.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 96 AGPLCSILVGRFGCRVTVMLGGVLASLGMVASSFSHNLSQLYFtAGFITGLGMCFSFQSSITVLG-FYFVRRRVLANALA 174
Cdd:TIGR00880 14 YSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLII-ARFLQGFGAAFALVAGAALIAdIYPPEERGVALGLM 92
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 2462558660 175 SMGVSLGITLWPLLSRYLLENLGWRGTFLVFGGIFLHCCICGAIIRP 221
Cdd:TIGR00880 93 SAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
46-204 |
5.22e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 49.09 E-value: 5.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 46 VLLATMVTQGLTLGFPTcigiffteLQWEFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASLGMV 125
Cdd:cd17321 5 VFLAALDVTIVNVALPT--------IARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 126 ASSFSHNLSQLyFTAGFITGLGMCFSFQSSITVLGFYF-VRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTFLV 204
Cdd:cd17321 77 LCALAPSLAFL-IAARALQGIGAAAIMPASLALIAATFpGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLI 155
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
48-202 |
5.70e-06 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 49.16 E-value: 5.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 48 LATMVTQGLTLGFPTCIGIFFTELQWEFQASnSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASLGMVAS 127
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADLGPS-SNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 128 SFSHNLSQLYFtAGFITGLGmcfsfqSSITVLGFYFV------RRRVLANALASMGVSLGITLWPLLSRYLLEN--LGWR 199
Cdd:cd06179 80 GTAKSVNMLIG-GQALIGIG------AGTQGLGAAVAselvpnKYRGLVQGVVNLVASPGSALGPLIAGALVEAnaAGWR 152
|
...
gi 2462558660 200 GTF 202
Cdd:cd06179 153 WIF 155
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
80-443 |
1.49e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 47.57 E-value: 1.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 80 SETSWFPSILTAVLHMAGPLCSILVG----RFGCRVTVMLGGVLASLGMVASSFSHNLSQLYFtAGFITGLGM-----CF 150
Cdd:cd17330 30 GASGYYVGLLQSSYSLGQFLASPLWGrlsdRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFL-ARFLDGLTGgnvsvAQ 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 151 SFQSSITVlgfyfVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTFLVFGGI-FLHCCICGAIIRPVatsvape 229
Cdd:cd17330 109 AYIADITD-----EEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALaLLNLVLVLFFLPPL------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 230 tkecppppPETPALGCLAACGrtiqrhlafdilrhntgycvyiLGVMWSVLGFPLPQVFlvpyamwhSVDEQQAALLISI 309
Cdd:cd17330 177 --------RRLLLVYFLIALA----------------------FAGLESVFSLFLKDRF--------GFSPSQIGLLLAL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 310 IGFSNIFLRplaGLMAGRPAFASHRKYLFSLALLLNGLTNLVCAASGDFWVLVGYCLAYSVSMSGIGALIFQVLMDIVPM 389
Cdd:cd17330 219 VGIAGILAQ---LLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPS 295
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 2462558660 390 DQFPRALGLFTVLDGLAFLISPPLAGLLLDAtNNFSYVFYMSSFFLISAALFMG 443
Cdd:cd17330 296 KEQGKAQGIIQSLQSLARIIGPLLAGPLYSF-LGPGVPFLLAAGLLLIALFLLS 348
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
280-459 |
1.62e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 47.59 E-value: 1.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 280 LGFPLPQVFLVPYAMWHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRPAfashRKYLFSLALLLNGLTNLVCAASGDFW 359
Cdd:cd17489 10 LSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFG----RKRLLLIGLLIFALATLLYLLATSVA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 360 VLVGYCLAYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDaTNNFSYVFYMSSFFLISAA 439
Cdd:cd17489 86 LLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQ-HLGFAVLFIVAAVLALLAL 164
|
170 180
....*....|....*....|
gi 2462558660 440 LFMGGSFYALQKKEQGKQAV 459
Cdd:cd17489 165 LLVFLVKDPPPVAAEEAEAG 184
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
68-449 |
1.68e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 47.57 E-value: 1.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 68 FTELQWEFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASLGMVASSFSHNLSQLYFtAGFITGLG 147
Cdd:cd17474 22 LPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLA-GRALQGIG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 148 MCFSFQSSITVLG-FYFVRRRVLANALASMGVSLGITLWPLLSRYLLEnLGWRGTFLVFGGIFLHCCICGAIIRPVATSV 226
Cdd:cd17474 101 AAGLGPLALTLIGdLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLAALIPVAFLAILFLLPEPKEK 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 227 APETKEcpppppetpalgclaacgrTIQRHLAFdILRHNTGYCVYILGVMWSVLGFPLpqVFLVPyamwhSVDEQQAALL 306
Cdd:cd17474 180 AKSSSA-------------------TKLRDLKK-ALRGRGLLTFLVSAFLYFFLYFAF--LTYLP-----FLLELLYGIS 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 307 ISIIGFsnIFLRPLAGLMAGRPAFAS------HRKYLFSLALLLNGLTNLVCAASGDFWVLVGYCLAYSVSMSGIGALIF 380
Cdd:cd17474 233 PIIIGL--LFAGWSVLLALGSLFVGRllkkrfGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLT 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462558660 381 QVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATNnfsyvfYMSSFFLISAALFMGGSFYAL 449
Cdd:cd17474 311 TLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFG------LSAPFLVGAAIALAAAVLLAL 373
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
270-442 |
4.86e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 46.00 E-value: 4.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 270 VYILGVMWSVLGFpLPQVFLVPYAMWHSVDEQQAALLISIigfSNIFlRPLAGLMAGRPAFASHRKYLFSLALLLNGLTN 349
Cdd:cd17370 204 LYLLAVALFALGN-FSFAFLILRAQELGLSAALIPLLYAL---FNLV-YALAAYPAGRLSDRIGRKKLLILGYLSLALAY 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 350 LVCAASGDFWVLVGYCLAYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDaTNNFSYVFY 429
Cdd:cd17370 279 LGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWD-LISPSAAFL 357
|
170
....*....|...
gi 2462558660 430 MSSFFLISAALFM 442
Cdd:cd17370 358 FSAVLALIALLLL 370
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
97-209 |
6.20e-05 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 45.81 E-value: 6.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 97 GPLCSilvgRFGcRVTVMLGGVLA-SLGMVASSFSHNLSQLYFtAGFITGLGMCFSFQSSITVLGFYF-VRRRVLANALA 174
Cdd:TIGR00895 73 GPLAD----RIG-RRRVLLWSILLfSVFTLLCALATNVTQLLI-LRFLAGLGLGGLMPNLNALVSEYApKRFRGTAVGLM 146
|
90 100 110
....*....|....*....|....*....|....*
gi 2462558660 175 SMGVSLGITLWPLLSRYLLENLGWRGTFLVfGGIF 209
Cdd:TIGR00895 147 FCGYPIGAAVGGFLAGWLIPVFGWRSLFYV-GGIA 180
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
55-420 |
8.77e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 45.00 E-value: 8.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 55 GLTLGFPTCIGIFFTELqweFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASLGMVASSFSHNLS 134
Cdd:cd17333 9 GLTDALLGILGPSLEEA---FNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIY 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 135 qLYFTAGFITGLGMCFSFQSSITVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLEN-LGWRGTFLVFGGIflhcc 213
Cdd:cd17333 86 -LFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSeLSWSWAYLIIGLI----- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 214 icgAIIRPVATSVAPETKECPPpppetpalgCLAACGRTIQRHLAFDILRhntgycvyILGVMWSVLGFPLPQVFLVPYA 293
Cdd:cd17333 160 ---YLLLAILILLTLFPELPSA---------RNPQQSVGAFSASASRLLR--------NPSIILGALALFLYVGAETAFS 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 294 MW--------HSVDEQQAALLISIIGFSNIFLRPLAGLMAGRPAFashRKYLFSLALLLNGLTNLVCAASGDFWVLVGyC 365
Cdd:cd17333 220 SWvpsylvekKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKP---HTLLVLSGSGALLGLLILLLAPTLVVGLVA-T 295
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 2462558660 366 LAYSVSMSGIGALIFQVLMDIVPMDQfPRALGLFTVLDGLAFLISPPLAGLLLDA 420
Cdd:cd17333 296 ALLGLFMAALFPTILSLGISNLPYAK-GKGTSVLLAAGSIGGAIIPFIMGFIAEA 349
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
86-398 |
1.24e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 44.55 E-value: 1.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 86 PSILTAVLHMAgplCSILVGRFGCRVTVMLGGVLASLGMVASSFSHNLSQLYFTAGFITGLGMCfSFQSSITVLGFYFVR 165
Cdd:cd17341 43 PVLAGALLRLP---YGFLCDRFGGRRVFIASLLLLLIPLLALALAVSSYWGLLVLGFLLGFAGA-NFASGQPWASFWFPK 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 166 RRV-LANALA----SMGVSLGITLWPLLSRYLLEN---LGWRGTFLVFGGIflhccicgAIIRPVATSVAPETKECPPPP 237
Cdd:cd17341 119 EKIgGAAGGIagagNMGVAVSQLLAPLIAGAIVFDggfVGWRNAFFVPGIL--------LAIAAVLVLLFGDDLPTGKAS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 238 PETPALGCLAACGRtiqrhlafdilRHNTGYCVYILGVMWSVLGFP--LPQVFLVPYAMwhsvDEQQAALLISIIGFSNI 315
Cdd:cd17341 191 ALEFLKVQLAVLKN-----------YRTWILSLLYGVTFGSFVGFSnvLPTYFKTRFGL----PLVTAGILAALFPLAGA 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 316 FLRPLAGLMAGRPAFAshRKYLFSLALLLNGLTNLVCAASGDFWVLVGYCLAYSVSMSGIGAlIFQVLMDIVPMdQFPRA 395
Cdd:cd17341 256 LARPAGGWLSDRFGGR--RRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLGAGA-GNGSVFRMVPF-IFRRE 331
|
...
gi 2462558660 396 LGL 398
Cdd:cd17341 332 LGA 334
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
47-187 |
1.41e-04 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 44.49 E-value: 1.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 47 LLATMVTQGLTLGFPTCIGIFF-------TELQWEFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVL 119
Cdd:cd17358 1 LLATFVANLGSFSFGIAVGWSSpalpslmSDNSLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 120 ASLGMVASSFSHNLSQLY---FTAGFITGL-------------------GMCFSFQSSITV---LGF---YFVRRRVLAN 171
Cdd:cd17358 81 CILGWLLIAFAKDVWMLYlgrFLAGFGGGAasvvvpvyiaeiapknvrgALGSLNQLLVNIgilLGYvlgSFLPWRTLAL 160
|
170
....*....|....*.
gi 2462558660 172 ALASMGVSLGITLWPL 187
Cdd:cd17358 161 IGAIPPVVFLILLFFI 176
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
87-223 |
3.04e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 43.34 E-value: 3.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 87 SILTAVLHMAGPLCSILVG----RFGCRVTVMLGGVLASLGMVASSFSHNLSQLYFTAGFITGLGMcFSFQSSITVLGFY 162
Cdd:cd17365 209 LTITLLLNIGGVIGSLLLGwladRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLAGACV-NGAQVGLYALAAR 287
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462558660 163 FVRRRVLANALASM-GVS-LGITLWPLLSRYLLE-NLGWRGTFLVFGGIFLHCCICGAIIRPVA 223
Cdd:cd17365 288 FYPTEVRATGVGWAlGVGrLGAILGPLLGGLLLAaGLGPESVFLALAIPAALGALAVLLLRLRR 351
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
44-220 |
3.84e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 43.33 E-value: 3.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 44 WVVLLATMVTQGLTLGFPTCIGIFFTELqweFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASLG 123
Cdd:COG2223 208 WLLSLLYFGTFGSFIGFSSWLPPYLVDQ---FGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALG 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 124 MVASSFSHNLSQLYFTAGFITGLGMCFSFQSSITVLGFYFVRRRV-LANALASMGVSLGITLWPLLSRYLLENLG-WRGT 201
Cdd:COG2223 285 LLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAgAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAA 364
|
170
....*....|....*....
gi 2462558660 202 FLVFGGIFLHCCICGAIIR 220
Cdd:COG2223 365 FLVFAVLALVALVLTLLLY 383
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
302-441 |
5.19e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.60 E-value: 5.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 302 QAALLISIIGFSNIFLRPLAGLMAGRPAfashRKYLFSLALLLNGLTNLVCAASGDFWVLVGYCLAYSVSMSGIGALIFQ 381
Cdd:cd17329 36 IVGLVLALSAVAGIVASLIGGRLADRFG----RKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEA 111
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 382 VLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDAtnNFSYVfymssfFLISAALF 441
Cdd:cd17329 112 MIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY--SFRLL------FLAAAVLF 163
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
334-442 |
5.31e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 42.56 E-value: 5.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 334 RKYLFSLALLLNGLTNLVCAASGDFWVLVGYCLAYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPPL 413
Cdd:cd17503 60 TRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTL 139
|
90 100
....*....|....*....|....*....
gi 2462558660 414 AGLLLDATnNFSYVFYMSSFFLISAALFM 442
Cdd:cd17503 140 GGWLTDNL-SWRWIFYINLPIGILALLLA 167
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
45-449 |
7.86e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 42.18 E-value: 7.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 45 VVLLATMVTQGLtlgfPTcigiffteLQWEFQASNSETSWfpsILTAVLhMAGPLCSILVGRFGCRV--TVMLGGVLA-- 120
Cdd:cd17504 8 VMLVETMLSPAL----PT--------IQREFGTSAAAVSW---VLTAYL-LVGAVSTPILGRLGDLYgrKKVLLIVLAiy 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 121 SLGMVASSFSHNLSQLYFtAGFITGLGMCfSFQSSITVLGFYFVRRRV---LANALASMGVSLGITLwpLLSRYLLENLG 197
Cdd:cd17504 72 TAGSLLAAFAPNLPVLIA-GRALQGIGGA-VFPLAFALVREEFPPERVpvaQGILSATFGIGAGIGL--PLGGWIVQHLG 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 198 WRGTFLVFGGIFLHCCICGAIIRPvatsvapetkecpppppetpalgclaacgrtiqrhlafDILRHNTGYCVYILGVMW 277
Cdd:cd17504 148 WRWIFWTAAPVAVLLAALVPLIDL--------------------------------------RLLRRRNVLLANITALLA 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 278 SVLGFPLPQVFLVPYAMWHSV----DEQQAALLISIIGFSNIFLRPLAGLMAGRpaFASHRKYLFSLALLLNGLTNLVCA 353
Cdd:cd17504 190 GFGMFMVFQLLPQLLQLPTPTgfglGITEAGLLLLPGALVMLIAGPLAGRLIAR--VGPRRVLLIGLVISAVGLLLLALL 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 354 ASGDFWVLVGYcLAYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSF 433
Cdd:cd17504 268 HSSLWALVVAL-LLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTVSITSGGVPTE 346
|
410 420
....*....|....*....|..
gi 2462558660 434 ------FLISAALFMGGSFYAL 449
Cdd:cd17504 347 gayvlaFLIGAALALAALLLSL 368
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
293-440 |
9.74e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 41.83 E-value: 9.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 293 AMWHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRPAFASHRKYLFSLALLLNGLTNLVCAASGDFWVLVGYCLAYSVSM 372
Cdd:cd06173 22 LPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFL 101
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462558660 373 SGIGALIFQ-----VLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLdATNNFSYVFYMSSF-FLISAAL 440
Cdd:cd06173 102 LGIASAFFGparqaLLPELVPKEQLVRANALNSLATQLARIIGPALGGLLV-ALLGPGGAFAINALsFLLSALL 174
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
269-442 |
1.21e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.41 E-value: 1.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 269 CVYILGVMWSVLGFPLPqvFLVPYAMWHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRPAfashRKYLFSLALLLNGLT 348
Cdd:cd17330 4 VVFLDALGFGIVFPVLP--FYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYG----RKPVLLLSLAGSAVS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 349 NLVCAASGDFWVLVGYCLAYSVSMSGIGAlIFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDAtNNFSYVF 428
Cdd:cd17330 78 YVLLGLSRNLWLLFLARFLDGLTGGNVSV-AQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTP-YGYALPF 155
|
170
....*....|....
gi 2462558660 429 YMSSFFLISAALFM 442
Cdd:cd17330 156 LVAAALALLNLVLV 169
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
87-441 |
1.42e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 41.39 E-value: 1.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 87 SILTAVLHMAGPLCSILVG----RFGCRVTVMLGGVLASLGMVASSFSHNLSQLyFTAGFITGLGMCFSFQSSITVLGFY 162
Cdd:cd17478 34 GLLVSVFSITSSLLQPLFGyladRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLL-LLLVALAGIGSAAFHPEGARLASQA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 163 FVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTFLVFGGIFLHCCIC----GAIIRPVATSVAPETKECPPPPP 238
Cdd:cd17478 113 AGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLllrlRPLKKPEAKKAAAKSSARSTLKG 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 239 ETPALGCLaacgrtiqrhLAFDILRHntgycvyilgvmWSVLGFplpQVFLVPYAMWHSVDEQQAALLISIIGFSNIFlr 318
Cdd:cd17478 193 VWRALLLL----------LIIVFLRS------------WVLSSL---TTFLPFYLVQRGYSLVFAGLLLSLFLFAGAI-- 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 319 plAGLMAGRPAFASHRKYLFSLALLLNGLTNLVCAASGDFW-----VLVGYCLAYSVSMsgIGALIFQVLMDIVPMdqfp 393
Cdd:cd17478 246 --GTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWsyillVLAGFLLFASFPV--TVVLAQELLPGNVGL---- 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 2462558660 394 rALGLFTvldGLAFL---ISPPLAGLLLDATnNFSYVFYMSSFFLISAALF 441
Cdd:cd17478 318 -ASGLMM---GLSFGlggIGAPVLGALADAF-GLESVLLILALLPLLGALL 363
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
44-219 |
1.71e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 41.02 E-value: 1.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 44 WVVLLATMVTQGLTLGFPTCIGIFFTELqweFQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASLG 123
Cdd:cd17473 200 LPIYFLAFLAMLLFYVIPIQLPFLLQER---GGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALG 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 124 MVASSFSHNLSQLyFTAGFITGLGMCFSF-QSSITVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENL-GWRGT 201
Cdd:cd17473 277 FLLLALASGLWVV-LLGAILAGLGFGLLLpTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTgGLSGA 355
|
170
....*....|....*...
gi 2462558660 202 FLVFGGIflhcCICGAII 219
Cdd:cd17473 356 FLILGVL----ALVLAIV 369
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
334-446 |
1.87e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 41.00 E-value: 1.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 334 RKYLFSLALLLNGLTNLVCAASGDFWVLVGYCLAYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPPL 413
Cdd:cd17321 60 RKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLL 139
|
90 100 110
....*....|....*....|....*....|...
gi 2462558660 414 AGLLLDAtNNFSYVFYMSSFFLIsAALFMGGSF 446
Cdd:cd17321 140 GGLLLEL-FGWRWIFLINVPIGL-VALLLARTF 170
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
83-199 |
1.92e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 40.64 E-value: 1.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 83 SWFPSILTAVLHMAG-----PLCSILVGRFGCRVTVMLGGVLASLGMVASSFSHNLSqLYFTAGFITGLGMCFSFQSSIt 157
Cdd:cd17317 23 RDWLVALVQTIFFLGvligsLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYE-LFLVLRFLVGVTSAGIFTVGF- 100
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 2462558660 158 VLGFYFV--RRRVLANALASMGVSLGITLWPLLSrYLLENlgWR 199
Cdd:cd17317 101 VLGMEIVgpKYRSFVGILFGLFWALGYMLLALLA-YLIRD--WR 141
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
302-469 |
2.25e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 40.62 E-value: 2.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 302 QAALLISIIGFSNIFLRPLAGLMAGRPAfashRKYLFSLALLLNGLTNLVCAASGDFWVLVGyclaySVSMSGIGALIFQ 381
Cdd:cd17478 32 QAGLLVSVFSITSSLLQPLFGYLADRKP----RRYLLPLGPLLTGLGLSLLGFAPNYWLLLL-----LVALAGIGSAAFH 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 382 VL-MDIVPM---DQFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFFLISAALFMGGSFYALQKKEQGKQ 457
Cdd:cd17478 103 PEgARLASQaagGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAA 182
|
170
....*....|..
gi 2462558660 458 AVAADALERDLF 469
Cdd:cd17478 183 KSSARSTLKGVW 194
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
106-208 |
3.61e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 39.87 E-value: 3.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 106 RFGcRVTVMLGG-VLASLGMVASSFSHNLSQLYFtAGFITGLGMCfsfqsSITVLGFYFVR------RRVLANALASMGV 178
Cdd:cd17320 60 RFG-RRPVLLAGlLLFILASLLCALASSIEQLLI-ARFLQGLGAA-----AGSVVARAIVRdlysgaELAKIFSLLMMIL 132
|
90 100 110
....*....|....*....|....*....|
gi 2462558660 179 SLGITLWPLLSRYLLENLGWRGTFLVFGGI 208
Cdd:cd17320 133 AIAPALAPLLGGLLLLFFGWRAIFVFLALL 162
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
303-442 |
4.31e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 39.94 E-value: 4.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 303 AALLISIIGFSNIFLRPLAGLMAGRpaFASHRKYLfsLALLLNGLTNLVCAASGDFWVLVGYCLAYSVSMSGIGALIFQV 382
Cdd:cd17391 242 SGLVFSATGVSSLLSAPRLGKLGDR--IGHHRILL--GALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSL 317
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90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 383 LMDIVPMDQFPRALGLFTVLDGLAFLISPpLAGLLLDATNNFSYVFYMSSFFLISAALFM 442
Cdd:cd17391 318 LAKITPKEVAGRIFGYNQSFQYLGNVAGP-LLGSAIAAHFGYRAVFVVTALLVLLNAIWS 376
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|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
334-449 |
4.37e-03 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 39.85 E-value: 4.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 334 RKYLFSLALLLNGLTNLVCAASGDF-WVLVGYCLAySVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPP 412
Cdd:cd17502 59 RKWVLLIAIVIFELGSLLCGLAPNMtMLIVGRAIQ-GIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPL 137
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 2462558660 413 LAGLLLDATnNFSYVFYM------------SSFFLISAALFM-GGSFYAL 449
Cdd:cd17502 138 IGGAFTDHL-SWRWCFYInlpigglalallRTILLSSIFGFLfGGALFGL 186
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|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
96-444 |
4.79e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 39.52 E-value: 4.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 96 AGPLCSILVGRFGCRVTVMLGGVLASLGMVASSFSHNLSqLYFTAGFITGLGMCFSFQSSITVLG-FYFVRRRVLANALA 174
Cdd:cd17329 51 ASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPW-LFAIALVLTGFGGGLFEPASEAMIAdVTTPENRTRAFSLL 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 175 SMGVSLGITLWPLLSRYLLEnLGWRGTFLVFGGIFLHCCICGAIIRPVATSVAPETKECPPPPPETPALgclaacgrtiq 254
Cdd:cd17329 130 YWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVL----------- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 255 rhlafdilrHNTGYCVYILGVMWSVLGFPLPQVFLVPYAM-WHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRPAfash 333
Cdd:cd17329 198 ---------RDRAFLLFLLASFLISLIYFQLESTLPVYVVeILGLGESLLGLLLALNALLIVLLQFPVARLVERFR---- 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462558660 334 RKYLFSLALLLNGLTNLVCAASGDFWVLVGYCLAYSVSMSgIGALIFQVLM-DIVPMDQFPRALGLFTVLDGLAFLISPP 412
Cdd:cd17329 265 LRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEM-LVFPAVQTLVaALAPPDKRGSYMGFYALAWGLGRAIGPL 343
|
330 340 350
....*....|....*....|....*....|..
gi 2462558660 413 LAGLLLDAtNNFSYVFYMSSFFLISAALFMGG 444
Cdd:cd17329 344 VGGLLLDL-LGPGLPWLILAALGLIAAALLLG 374
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