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Conserved domains on  [gi|2462556509|ref|XP_054172693|]
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plexin domain-containing protein 1 isoform X8 [Homo sapiens]

Protein Classification

attractin family protein( domain architecture ID 10250010)

attractin is involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 235-288 9.47e-06

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


:

Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 42.70  E-value: 9.47e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462556509 235 TCLQHRSCDACMSSDlTFNCSWCHVLQRSlnnQDENTCSSgFDRYRQEWMDYGC 288
Cdd:pfam01437   1 RCSQYTSCSSCLAAR-DPYCGWCSSEGRC---VRRSACGA-PEGNCEEWEQASS 49
NIDO super family cl02648
Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found ...
 84-174 3.27e-04

Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function.


The actual alignment was detected with superfamily member smart00539:

Pssm-ID: 470642  Cd Length: 152  Bit Score: 40.87  E-value: 3.27e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462556509   84 TIATGGFIFMGDVIHRML-TATQYVaplmanfNPGYSDNSTvvyFDNGTVFVVQWDHV-YLQGWEDKGSFTFQAALHHDG 161
Cdd:smart00539   8 TEGTGKVYYRETTDHAILdRATESV-------REGFTDMGG---FRAKSVVIVTWENVaAYGSQSSDGTNTFQAVLATDG 77

                           90
                   ....*....|....*.
gi 2462556509  162 RIVFA---YKEIPMSV 174
Cdd:smart00539  78 SRTYAiflYPSLGWTS 93
 
Name Accession Description Interval E-value
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 235-288 9.47e-06

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 42.70  E-value: 9.47e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462556509 235 TCLQHRSCDACMSSDlTFNCSWCHVLQRSlnnQDENTCSSgFDRYRQEWMDYGC 288
Cdd:pfam01437   1 RCSQYTSCSSCLAAR-DPYCGWCSSEGRC---VRRSACGA-PEGNCEEWEQASS 49
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
84-174 3.27e-04

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


Pssm-ID: 214712  Cd Length: 152  Bit Score: 40.87  E-value: 3.27e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462556509   84 TIATGGFIFMGDVIHRML-TATQYVaplmanfNPGYSDNSTvvyFDNGTVFVVQWDHV-YLQGWEDKGSFTFQAALHHDG 161
Cdd:smart00539   8 TEGTGKVYYRETTDHAILdRATESV-------REGFTDMGG---FRAKSVVIVTWENVaAYGSQSSDGTNTFQAVLATDG 77

                           90
                   ....*....|....*.
gi 2462556509  162 RIVFA---YKEIPMSV 174
Cdd:smart00539  78 SRTYAiflYPSLGWTS 93
 
Name Accession Description Interval E-value
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 235-288 9.47e-06

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 42.70  E-value: 9.47e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462556509 235 TCLQHRSCDACMSSDlTFNCSWCHVLQRSlnnQDENTCSSgFDRYRQEWMDYGC 288
Cdd:pfam01437   1 RCSQYTSCSSCLAAR-DPYCGWCSSEGRC---VRRSACGA-PEGNCEEWEQASS 49
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
84-174 3.27e-04

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


Pssm-ID: 214712  Cd Length: 152  Bit Score: 40.87  E-value: 3.27e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462556509   84 TIATGGFIFMGDVIHRML-TATQYVaplmanfNPGYSDNSTvvyFDNGTVFVVQWDHV-YLQGWEDKGSFTFQAALHHDG 161
Cdd:smart00539   8 TEGTGKVYYRETTDHAILdRATESV-------REGFTDMGG---FRAKSVVIVTWENVaAYGSQSSDGTNTFQAVLATDG 77

                           90
                   ....*....|....*.
gi 2462556509  162 RIVFA---YKEIPMSV 174
Cdd:smart00539  78 SRTYAiflYPSLGWTS 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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