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Conserved domains on  [gi|2462553254|ref|XP_054171109|]
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CMRF35-like molecule 1 isoform X2 [Homo sapiens]

Protein Classification

Ig_pIgR_like and SIT domain-containing protein( domain architecture ID 10146073)

Ig_pIgR_like and SIT domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SIT pfam15330
SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane ...
 223-304 8.43e-34

SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane adaptor protein, is a disulfide-linked dimer that regulates human T Cell activation.


:

Pssm-ID: 464650  Cd Length: 114  Bit Score: 120.57  E-value: 8.43e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553254 223 WRMMKYQQKAAGMSPEQV------LQPLEGDLCYADLTLQLAGTSP----RKATTKL-SSAQVDQVEVEYVTMASLPKED 291
Cdd:pfam15330  22 WRMMKRQKKAAGYSPEQVipreyyLQPIEGDLCYANLTLQQTGTSPgssdEKAYEQMsSSAQRSQNEVEYVTMAPFPREE 101

                          90
                  ....*....|...
gi 2462553254 292 ISYASLTLGAEDQ 304
Cdd:pfam15330 102 ISYASLSLDVLDQ 114
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 22-125 1.22e-31

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 114.42  E-value: 1.22e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553254  22 ITGPTTVNGLERGSLTVQCVYRSGWETYLKWWCRGAIWRdCKILVKTSGSEQEvkrDRVSIKDNQKNRTFTVTMEDLMKT 101
Cdd:cd05716     1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEG-CQTLVSSEGVVPG---GRISLTDDPDNGVFTVTLNQLRKE 76

                          90       100
                  ....*....|....*....|....
gi 2462553254 102 DADTYWCGIeKTGNDLGVTVQVTI 125
Cdd:cd05716    77 DAGWYWCGV-GDDGDRGLTVQVKL 99
 
Name Accession Description Interval E-value
SIT pfam15330
SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane ...
 223-304 8.43e-34

SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane adaptor protein, is a disulfide-linked dimer that regulates human T Cell activation.


Pssm-ID: 464650  Cd Length: 114  Bit Score: 120.57  E-value: 8.43e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553254 223 WRMMKYQQKAAGMSPEQV------LQPLEGDLCYADLTLQLAGTSP----RKATTKL-SSAQVDQVEVEYVTMASLPKED 291
Cdd:pfam15330  22 WRMMKRQKKAAGYSPEQVipreyyLQPIEGDLCYANLTLQQTGTSPgssdEKAYEQMsSSAQRSQNEVEYVTMAPFPREE 101

                          90
                  ....*....|...
gi 2462553254 292 ISYASLTLGAEDQ 304
Cdd:pfam15330 102 ISYASLSLDVLDQ 114
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 22-125 1.22e-31

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 114.42  E-value: 1.22e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553254  22 ITGPTTVNGLERGSLTVQCVYRSGWETYLKWWCRGAIWRdCKILVKTSGSEQEvkrDRVSIKDNQKNRTFTVTMEDLMKT 101
Cdd:cd05716     1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEG-CQTLVSSEGVVPG---GRISLTDDPDNGVFTVTLNQLRKE 76

                          90       100
                  ....*....|....*....|....
gi 2462553254 102 DADTYWCGIeKTGNDLGVTVQVTI 125
Cdd:cd05716    77 DAGWYWCGV-GDDGDRGLTVQVKL 99
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 23-125 2.13e-12

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 62.86  E-value: 2.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553254  23 TGPTTVNGLERGSLTVQCVYRSGW--ETYLKWWCRG--AIWRDCKILVKTSGSEQEVKRDRVSIKDNQKNRTFTVTMEDL 98
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMseASTSVYWYRQppGKGPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNL 80

                          90       100
                  ....*....|....*....|....*...
gi 2462553254  99 MKTDADTYWCGIEKTG-NDLGVTVQVTI 125
Cdd:pfam07686  81 TLSDSGTYTCAVIPSGeGVFGKGTRLTV 108
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 25-125 2.90e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 36.33  E-value: 2.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553254   25 PTTVNGLERGSLTVQCVYrSGWETYLKWWcrgaiWRDCKILVKTSGseqevkrdRVSIKDNqkNRTFTVTMEDLMKTDAD 104
Cdd:smart00410   1 PPSVTVKEGESVTLSCEA-SGSPPPEVTW-----YKQGGKLLAESG--------RFSVSRS--GSTSTLTISNVTPEDSG 64

                           90       100
                   ....*....|....*....|.
gi 2462553254  105 TYWCGIEKTGNDLGVTVQVTI 125
Cdd:smart00410  65 TYTCAATNSSGSASSGTTLTV 85
 
Name Accession Description Interval E-value
SIT pfam15330
SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane ...
 223-304 8.43e-34

SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane adaptor protein, is a disulfide-linked dimer that regulates human T Cell activation.


Pssm-ID: 464650  Cd Length: 114  Bit Score: 120.57  E-value: 8.43e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553254 223 WRMMKYQQKAAGMSPEQV------LQPLEGDLCYADLTLQLAGTSP----RKATTKL-SSAQVDQVEVEYVTMASLPKED 291
Cdd:pfam15330  22 WRMMKRQKKAAGYSPEQVipreyyLQPIEGDLCYANLTLQQTGTSPgssdEKAYEQMsSSAQRSQNEVEYVTMAPFPREE 101

                          90
                  ....*....|...
gi 2462553254 292 ISYASLTLGAEDQ 304
Cdd:pfam15330 102 ISYASLSLDVLDQ 114
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 22-125 1.22e-31

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 114.42  E-value: 1.22e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553254  22 ITGPTTVNGLERGSLTVQCVYRSGWETYLKWWCRGAIWRdCKILVKTSGSEQEvkrDRVSIKDNQKNRTFTVTMEDLMKT 101
Cdd:cd05716     1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGSEG-CQTLVSSEGVVPG---GRISLTDDPDNGVFTVTLNQLRKE 76

                          90       100
                  ....*....|....*....|....
gi 2462553254 102 DADTYWCGIeKTGNDLGVTVQVTI 125
Cdd:cd05716    77 DAGWYWCGV-GDDGDRGLTVQVKL 99
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 23-125 2.13e-12

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 62.86  E-value: 2.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553254  23 TGPTTVNGLERGSLTVQCVYRSGW--ETYLKWWCRG--AIWRDCKILVKTSGSEQEVKRDRVSIKDNQKNRTFTVTMEDL 98
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMseASTSVYWYRQppGKGPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNL 80

                          90       100
                  ....*....|....*....|....*...
gi 2462553254  99 MKTDADTYWCGIEKTG-NDLGVTVQVTI 125
Cdd:pfam07686  81 TLSDSGTYTCAVIPSGeGVFGKGTRLTV 108
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 25-125 2.90e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 36.33  E-value: 2.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553254   25 PTTVNGLERGSLTVQCVYrSGWETYLKWWcrgaiWRDCKILVKTSGseqevkrdRVSIKDNqkNRTFTVTMEDLMKTDAD 104
Cdd:smart00410   1 PPSVTVKEGESVTLSCEA-SGSPPPEVTW-----YKQGGKLLAESG--------RFSVSRS--GSTSTLTISNVTPEDSG 64

                           90       100
                   ....*....|....*....|.
gi 2462553254  105 TYWCGIEKTGNDLGVTVQVTI 125
Cdd:smart00410  65 TYTCAATNSSGSASSGTTLTV 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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