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Conserved domains on  [gi|2429179552|ref|XP_052901266|]
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frataxin homolog, mitochondrial [Anopheles moucheti]

Protein Classification

frataxin family protein( domain architecture ID 10478730)

frataxin family protein promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways; similar to Iron-sulfur cluster assembly protein CyaY and frataxin

CATH:  3.30.920.10
Gene Ontology:  GO:0008199|GO:0008198|GO:0016226
SCOP:  4001566
TCDB:  9.B.21

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Frataxin_Cyay pfam01491
Frataxin-like domain; This family contains proteins that have a domain related to the globular ...
 65-180 1.45e-46

Frataxin-like domain; This family contains proteins that have a domain related to the globular C-terminus of Frataxin the protein that is mutated in Friedreich's ataxia. This domain is found in a family of bacterial proteins. The function of this domain is currently unknown. It has been suggested that this family is involved in iron transport.


:

Pssm-ID: 460230  Cd Length: 106  Bit Score: 148.83  E-value: 1.45e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429179552  65 IDSVTFVTVCSDTLESLVDYFEQIVDETStlkNPDVTYGDGVLTVSFGePYGTYVINRQLPNRQIWLSSPTSGPKRYDFi 144
Cdd:pfam01491   1 MTDSEFHRLADATLESLEDSLEELLDEGS---DADVEYSGGVLTLEFD-NGGTYVINKQPPNRQIWLSSPISGPFHFDY- 75

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2429179552 145 pdkrtVNEGYWLYRHDGVTLHELLQKEISAIVGRKL 180
Cdd:pfam01491  76 -----DDAGQWIYTRDGEELFELLSRELSEQLGEPV 106
 
Name Accession Description Interval E-value
Frataxin_Cyay pfam01491
Frataxin-like domain; This family contains proteins that have a domain related to the globular ...
 65-180 1.45e-46

Frataxin-like domain; This family contains proteins that have a domain related to the globular C-terminus of Frataxin the protein that is mutated in Friedreich's ataxia. This domain is found in a family of bacterial proteins. The function of this domain is currently unknown. It has been suggested that this family is involved in iron transport.


Pssm-ID: 460230  Cd Length: 106  Bit Score: 148.83  E-value: 1.45e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429179552  65 IDSVTFVTVCSDTLESLVDYFEQIVDETStlkNPDVTYGDGVLTVSFGePYGTYVINRQLPNRQIWLSSPTSGPKRYDFi 144
Cdd:pfam01491   1 MTDSEFHRLADATLESLEDSLEELLDEGS---DADVEYSGGVLTLEFD-NGGTYVINKQPPNRQIWLSSPISGPFHFDY- 75

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2429179552 145 pdkrtVNEGYWLYRHDGVTLHELLQKEISAIVGRKL 180
Cdd:pfam01491  76 -----DDAGQWIYTRDGEELFELLSRELSEQLGEPV 106
mito_frataxin TIGR03422
frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease ...
 69-173 1.21e-44

frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease Friedreich's ataxia. Its orthologs are widely distributed in the bacteria, associated with the ISC system for iron-sulfur cluster assembly, and designated CyaY. This exception-type model allows those examples of frataxin per se that score above the trusted cutoff to the CyaY equivalog-type model (TIGR03421) to be named appropriately.


Pssm-ID: 132463  Cd Length: 97  Bit Score: 143.53  E-value: 1.21e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429179552  69 TFVTVCSDTLESLVDYFEQIVDETSTLkNPDVTYGDGVLTVSFGePYGTYVINRQLPNRQIWLSSPTSGPKRYDFIpdkr 148
Cdd:TIGR03422   1 EYHKVADEYLDHLLDKLEELGESRPDL-DFDVEYSSGVLTLELP-SVGTYVINKQPPNKQIWLSSPVSGPKRYDYV---- 74

                          90       100
                  ....*....|....*....|....*
gi 2429179552 149 tvnEGYWLYRHDGVTLHELLQKEIS 173
Cdd:TIGR03422  75 ---NGEWIYLRDGSSLTELLEEELS 96
Frataxin cd00503
Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), ...
 65-182 4.56e-42

Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in the mitochondrial matrix suggesting that frataxin is involved in mitochondrial iron homeostasis and possibly in iron transport; the domain has an alpha-beta fold consisting of two helices flanking an antiparallel beta sheet.


Pssm-ID: 238280  Cd Length: 105  Bit Score: 137.01  E-value: 4.56e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429179552  65 IDSVTFVTVCSDTLESLVDYFEQIVDEtstlKNPDVTYGDGVLTVSFGEpYGTYVINRQLPNRQIWLSSPtSGPKRYDFi 144
Cdd:cd00503     1 MNESEFHRLADDLLLKIEDTLEEQDDD----ADIDVETQGGVLTLTFGN-GSTIVINRQEPLRQIWLASK-VGGYHFDY- 73

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2429179552 145 pdkrtvNEGYWLYRHDGVTLHELLQKEISAIVGRKLEF 182
Cdd:cd00503    74 ------KNGKWICTRSGEELWELLEEECSAQSGEDVEF 105
CyaY COG1965
Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; ...
 54-182 3.92e-14

Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; Fe-S cluster assembly protein CyaY, frataxin homolog is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441568  Cd Length: 106  Bit Score: 65.20  E-value: 3.92e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429179552  54 MNPNDFIAtsLIDsvtfvtvcsDTLESLvdyfEQIVDETSTLKnPDVTYGDGVLTVSFgEPYGTYVINRQLPNRQIWLSS 133
Cdd:COG1965     1 MTESEFHQ--LAD---------ALLEAI----EEALDRDDDAD-IDCERSGGVLTLEF-DNGSKIIINRQEPLRQIWLAA 63

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2429179552 134 PtSGPKRYDFIpdkrtvnEGYWLYRHDGVTLHELLQKEISAIVGRKLEF 182
Cdd:COG1965    64 K-SGGFHFDYD-------DGKWIDTRSGEELFALLSRALSEQAGEPVTL 104
cyaY PRK00446
frataxin-like protein; Provisional
 79-182 1.99e-08

frataxin-like protein; Provisional


Pssm-ID: 234765  Cd Length: 105  Bit Score: 50.27  E-value: 1.99e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429179552  79 ESLVDYFEQIVDETSTLknpDVTYGD--GVLTVSFGEpyGT-YVINRQLPNRQIWLSSpTSGPKRYDFipdkrtvNEGYW 155
Cdd:PRK00446   11 DALWQAIEEQLDDDGDA---DIDCERngGVLTLTFEN--GSkIIINRQEPLHELWLAA-KSGGFHFDY-------KDGEW 77

                          90       100
                  ....*....|....*....|....*..
gi 2429179552 156 LYRHDGVTLHELLQKEISAIVGRKLEF 182
Cdd:PRK00446   78 ICDRSGEEFWALLEEAATQQAGEPVSF 104
 
Name Accession Description Interval E-value
Frataxin_Cyay pfam01491
Frataxin-like domain; This family contains proteins that have a domain related to the globular ...
 65-180 1.45e-46

Frataxin-like domain; This family contains proteins that have a domain related to the globular C-terminus of Frataxin the protein that is mutated in Friedreich's ataxia. This domain is found in a family of bacterial proteins. The function of this domain is currently unknown. It has been suggested that this family is involved in iron transport.


Pssm-ID: 460230  Cd Length: 106  Bit Score: 148.83  E-value: 1.45e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429179552  65 IDSVTFVTVCSDTLESLVDYFEQIVDETStlkNPDVTYGDGVLTVSFGePYGTYVINRQLPNRQIWLSSPTSGPKRYDFi 144
Cdd:pfam01491   1 MTDSEFHRLADATLESLEDSLEELLDEGS---DADVEYSGGVLTLEFD-NGGTYVINKQPPNRQIWLSSPISGPFHFDY- 75

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2429179552 145 pdkrtVNEGYWLYRHDGVTLHELLQKEISAIVGRKL 180
Cdd:pfam01491  76 -----DDAGQWIYTRDGEELFELLSRELSEQLGEPV 106
mito_frataxin TIGR03422
frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease ...
 69-173 1.21e-44

frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease Friedreich's ataxia. Its orthologs are widely distributed in the bacteria, associated with the ISC system for iron-sulfur cluster assembly, and designated CyaY. This exception-type model allows those examples of frataxin per se that score above the trusted cutoff to the CyaY equivalog-type model (TIGR03421) to be named appropriately.


Pssm-ID: 132463  Cd Length: 97  Bit Score: 143.53  E-value: 1.21e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429179552  69 TFVTVCSDTLESLVDYFEQIVDETSTLkNPDVTYGDGVLTVSFGePYGTYVINRQLPNRQIWLSSPTSGPKRYDFIpdkr 148
Cdd:TIGR03422   1 EYHKVADEYLDHLLDKLEELGESRPDL-DFDVEYSSGVLTLELP-SVGTYVINKQPPNKQIWLSSPVSGPKRYDYV---- 74

                          90       100
                  ....*....|....*....|....*
gi 2429179552 149 tvnEGYWLYRHDGVTLHELLQKEIS 173
Cdd:TIGR03422  75 ---NGEWIYLRDGSSLTELLEEELS 96
Frataxin cd00503
Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), ...
 65-182 4.56e-42

Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in the mitochondrial matrix suggesting that frataxin is involved in mitochondrial iron homeostasis and possibly in iron transport; the domain has an alpha-beta fold consisting of two helices flanking an antiparallel beta sheet.


Pssm-ID: 238280  Cd Length: 105  Bit Score: 137.01  E-value: 4.56e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429179552  65 IDSVTFVTVCSDTLESLVDYFEQIVDEtstlKNPDVTYGDGVLTVSFGEpYGTYVINRQLPNRQIWLSSPtSGPKRYDFi 144
Cdd:cd00503     1 MNESEFHRLADDLLLKIEDTLEEQDDD----ADIDVETQGGVLTLTFGN-GSTIVINRQEPLRQIWLASK-VGGYHFDY- 73

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2429179552 145 pdkrtvNEGYWLYRHDGVTLHELLQKEISAIVGRKLEF 182
Cdd:cd00503    74 ------KNGKWICTRSGEELWELLEEECSAQSGEDVEF 105
FeS_CyaY TIGR03421
iron donor protein CyaY; Members of this protein family are the iron-sulfur cluster (FeS) ...
 79-182 1.10e-18

iron donor protein CyaY; Members of this protein family are the iron-sulfur cluster (FeS) metabolism protein CyaY, a homolog of eukaryotic frataxin. ISC is one of several bacterial systems for FeS assembly; we find by Partial Phylogenetic Profiling vs. the ISC system that CyaY most like work with the ISC system for FeS cluster biosynthesis. A study of of cyaY mutants in Salmonella enterica bears this out. Although the trusted cutoff is set low enough to include eukaryotic frataxin sequences, a narrower, exception-type model (TIGR03421) identifies identifies members of that specific set. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 274572  Cd Length: 102  Bit Score: 77.25  E-value: 1.10e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429179552  79 ESLVDYFEQIVDETStlKNPDVTYGDGVLTVSFGEPyGTYVINRQLPNRQIWLSSPtSGPKRYDFIpdkrtvnEGYWLYR 158
Cdd:TIGR03421  10 EALLDAIEEAIDDGD--ADIDCERQGGVLTLTFENG-SQIIINKQEPLHQIWLAAK-SGGFHFDYD-------GGAWIDT 78

                          90       100
                  ....*....|....*....|....
gi 2429179552 159 HDGVTLHELLQKEISAIVGRKLEF 182
Cdd:TIGR03421  79 RDGEELWALLARACSEQAGEPVVF 102
CyaY COG1965
Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; ...
 54-182 3.92e-14

Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; Fe-S cluster assembly protein CyaY, frataxin homolog is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441568  Cd Length: 106  Bit Score: 65.20  E-value: 3.92e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429179552  54 MNPNDFIAtsLIDsvtfvtvcsDTLESLvdyfEQIVDETSTLKnPDVTYGDGVLTVSFgEPYGTYVINRQLPNRQIWLSS 133
Cdd:COG1965     1 MTESEFHQ--LAD---------ALLEAI----EEALDRDDDAD-IDCERSGGVLTLEF-DNGSKIIINRQEPLRQIWLAA 63

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2429179552 134 PtSGPKRYDFIpdkrtvnEGYWLYRHDGVTLHELLQKEISAIVGRKLEF 182
Cdd:COG1965    64 K-SGGFHFDYD-------DGKWIDTRSGEELFALLSRALSEQAGEPVTL 104
cyaY PRK00446
frataxin-like protein; Provisional
 79-182 1.99e-08

frataxin-like protein; Provisional


Pssm-ID: 234765  Cd Length: 105  Bit Score: 50.27  E-value: 1.99e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429179552  79 ESLVDYFEQIVDETSTLknpDVTYGD--GVLTVSFGEpyGT-YVINRQLPNRQIWLSSpTSGPKRYDFipdkrtvNEGYW 155
Cdd:PRK00446   11 DALWQAIEEQLDDDGDA---DIDCERngGVLTLTFEN--GSkIIINRQEPLHELWLAA-KSGGFHFDY-------KDGEW 77

                          90       100
                  ....*....|....*....|....*..
gi 2429179552 156 LYRHDGVTLHELLQKEISAIVGRKLEF 182
Cdd:PRK00446   78 ICDRSGEEFWALLEEAATQQAGEPVSF 104
cyaY PRK01379
iron donor protein CyaY;
75-172 8.55e-06

iron donor protein CyaY;


Pssm-ID: 134546  Cd Length: 103  Bit Score: 43.00  E-value: 8.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429179552  75 SDTLESLVDYFEQIVDETSTLKNPDVTYGDGVLTVSFGEpyGTYVINRQLPNRQIWLSSPTSGPkrYDFIPDkrtvnEGY 154
Cdd:PRK01379    7 SKIAETTIAYIADKIEEQDKEASIDVDLQGDILNLDTDK--GIYVINKQSAAKEIWLSSPVSGP--YHFFYE-----QGK 77

                          90
                  ....*....|....*...
gi 2429179552 155 WLYRHdGVTLHELLQKEI 172
Cdd:PRK01379   78 WKNRA-GLELMAILTEEL 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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