NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2411765240|ref|XP_052517127|]
View 

elongation of very long chain fatty acids protein 3 [Budorcas taxicolor]

Protein Classification

elongation of very long chain fatty acids protein( domain architecture ID 10471715)

elongation of very long chain fatty acids protein catalyzes the first and rate-limiting reaction of the four steps that constitute the long-chain fatty acids elongation cycle

EC:  2.3.1.199
Gene Ontology:  GO:0009922|GO:0042761

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
ELO pfam01151
GNS1/SUR4 family; Members of this family are involved in long chain fatty acid elongation ...
29-266 4.56e-67

GNS1/SUR4 family; Members of this family are involved in long chain fatty acid elongation systems that produce the 26-carbon precursors for ceramide and sphingolipid synthesis. Predicted to be integral membrane proteins, in eukaryotes they are probably located on the endoplasmic reticulum. Yeast ELO3 affects plasma membrane H+-ATPase activity, and may act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1.


:

Pssm-ID: 460083  Cd Length: 242  Bit Score: 208.24  E-value: 4.56e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2411765240  29 FLEEYWATSFAIALIYLLLIFVGQNYMKSRKGFNLQRPLILWSFCLAVFSIFGTLRMWGYMGTLLLrgSPKQTICF--SS 106
Cdd:pfam01151   1 PLLSSPDPVILIIVLYLLFVFLGPKLMRNRKPFDLRRLLIVYNLFLSLFSLYGFYGMLPALLGWLY--GFFWSLCQpsES 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2411765240 107 FINSPIIQFWSFLFVLSKVVELGDTAFIILRKRPLIFVHWYHHSTVLVYSSFGYKNKVAAGGWFM-TMNFGVHAIMYTYY 185
Cdd:pfam01151  79 PFAQGLVGFWYYLFYLSKILELLDTVFLVLRKKQLSFLHVYHHSTMLLYSWLGYKYGTGGVGWFFiLLNSFVHVIMYFYY 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2411765240 186 TLKAA-KVKSPSWFPMLVTSLQILQMFIGA--TVCILAYIWRQEKGCHTTEEHFFWSFILYATYFVLFAKFFHQNYIIPK 262
Cdd:pfam01151 159 FLAALgNKKLPRWWKKYITQLQILQFVIGLahTVYALYQYYLGPYGCDGPRFAARLGLVMYLSYLFLFSNFYIKSYLKPK 238

                  ....
gi 2411765240 263 IKAK 266
Cdd:pfam01151 239 KKKA 242
 
Name Accession Description Interval E-value
ELO pfam01151
GNS1/SUR4 family; Members of this family are involved in long chain fatty acid elongation ...
29-266 4.56e-67

GNS1/SUR4 family; Members of this family are involved in long chain fatty acid elongation systems that produce the 26-carbon precursors for ceramide and sphingolipid synthesis. Predicted to be integral membrane proteins, in eukaryotes they are probably located on the endoplasmic reticulum. Yeast ELO3 affects plasma membrane H+-ATPase activity, and may act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1.


Pssm-ID: 460083  Cd Length: 242  Bit Score: 208.24  E-value: 4.56e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2411765240  29 FLEEYWATSFAIALIYLLLIFVGQNYMKSRKGFNLQRPLILWSFCLAVFSIFGTLRMWGYMGTLLLrgSPKQTICF--SS 106
Cdd:pfam01151   1 PLLSSPDPVILIIVLYLLFVFLGPKLMRNRKPFDLRRLLIVYNLFLSLFSLYGFYGMLPALLGWLY--GFFWSLCQpsES 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2411765240 107 FINSPIIQFWSFLFVLSKVVELGDTAFIILRKRPLIFVHWYHHSTVLVYSSFGYKNKVAAGGWFM-TMNFGVHAIMYTYY 185
Cdd:pfam01151  79 PFAQGLVGFWYYLFYLSKILELLDTVFLVLRKKQLSFLHVYHHSTMLLYSWLGYKYGTGGVGWFFiLLNSFVHVIMYFYY 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2411765240 186 TLKAA-KVKSPSWFPMLVTSLQILQMFIGA--TVCILAYIWRQEKGCHTTEEHFFWSFILYATYFVLFAKFFHQNYIIPK 262
Cdd:pfam01151 159 FLAALgNKKLPRWWKKYITQLQILQFVIGLahTVYALYQYYLGPYGCDGPRFAARLGLVMYLSYLFLFSNFYIKSYLKPK 238

                  ....
gi 2411765240 263 IKAK 266
Cdd:pfam01151 239 KKKA 242
PTZ00251 PTZ00251
fatty acid elongase; Provisional
40-262 7.71e-20

fatty acid elongase; Provisional


Pssm-ID: 140278  Cd Length: 272  Bit Score: 86.44  E-value: 7.71e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2411765240  40 IALIYLLLIFVGQNYMKSRKGFNLQRPLI-----LWSFCLAVFSIFGTLRMWGYMGTLLLRGSPKQTICF---SSFINSP 111
Cdd:PTZ00251   31 IAAAYLTFVFKGPQLVDAIFHGNPPVPLIkkcwaLWNIGLSVFSMYGVYRVVPPLLNNLRKYGLHDTLCTfreDEFYTGK 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2411765240 112 IiQFWSFLFVLSKVVELGDTAFIILRKRPLIFVHWYHHSTVLVYSSFGYKNKVAAGGWFMTMNFGVHAIMYTYYTLKAAK 191
Cdd:PTZ00251  111 V-GVAMGLFSISKVPEFGDTFFLIMGGKKLPFLSWFHHVTIFLYAWMSYQQGSSIWICAAAMNYFVHSIMYFYFALSEAG 189
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2411765240 192 VKS-PSWFPMLVTSLQILQM----FIGATVCILAYIWRQEKGCH-TTEEHFFWSFILYATYFVLFAKFFHQNYIIPK 262
Cdd:PTZ00251  190 FKKlVKPFAMYITLLQITQMvgglFVSGYVIVQKLTKGDPKGCSgTTMATARGQLMIYIFNFYLFSEMFVKGYVLPR 266
 
Name Accession Description Interval E-value
ELO pfam01151
GNS1/SUR4 family; Members of this family are involved in long chain fatty acid elongation ...
29-266 4.56e-67

GNS1/SUR4 family; Members of this family are involved in long chain fatty acid elongation systems that produce the 26-carbon precursors for ceramide and sphingolipid synthesis. Predicted to be integral membrane proteins, in eukaryotes they are probably located on the endoplasmic reticulum. Yeast ELO3 affects plasma membrane H+-ATPase activity, and may act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1.


Pssm-ID: 460083  Cd Length: 242  Bit Score: 208.24  E-value: 4.56e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2411765240  29 FLEEYWATSFAIALIYLLLIFVGQNYMKSRKGFNLQRPLILWSFCLAVFSIFGTLRMWGYMGTLLLrgSPKQTICF--SS 106
Cdd:pfam01151   1 PLLSSPDPVILIIVLYLLFVFLGPKLMRNRKPFDLRRLLIVYNLFLSLFSLYGFYGMLPALLGWLY--GFFWSLCQpsES 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2411765240 107 FINSPIIQFWSFLFVLSKVVELGDTAFIILRKRPLIFVHWYHHSTVLVYSSFGYKNKVAAGGWFM-TMNFGVHAIMYTYY 185
Cdd:pfam01151  79 PFAQGLVGFWYYLFYLSKILELLDTVFLVLRKKQLSFLHVYHHSTMLLYSWLGYKYGTGGVGWFFiLLNSFVHVIMYFYY 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2411765240 186 TLKAA-KVKSPSWFPMLVTSLQILQMFIGA--TVCILAYIWRQEKGCHTTEEHFFWSFILYATYFVLFAKFFHQNYIIPK 262
Cdd:pfam01151 159 FLAALgNKKLPRWWKKYITQLQILQFVIGLahTVYALYQYYLGPYGCDGPRFAARLGLVMYLSYLFLFSNFYIKSYLKPK 238

                  ....
gi 2411765240 263 IKAK 266
Cdd:pfam01151 239 KKKA 242
PTZ00251 PTZ00251
fatty acid elongase; Provisional
40-262 7.71e-20

fatty acid elongase; Provisional


Pssm-ID: 140278  Cd Length: 272  Bit Score: 86.44  E-value: 7.71e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2411765240  40 IALIYLLLIFVGQNYMKSRKGFNLQRPLI-----LWSFCLAVFSIFGTLRMWGYMGTLLLRGSPKQTICF---SSFINSP 111
Cdd:PTZ00251   31 IAAAYLTFVFKGPQLVDAIFHGNPPVPLIkkcwaLWNIGLSVFSMYGVYRVVPPLLNNLRKYGLHDTLCTfreDEFYTGK 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2411765240 112 IiQFWSFLFVLSKVVELGDTAFIILRKRPLIFVHWYHHSTVLVYSSFGYKNKVAAGGWFMTMNFGVHAIMYTYYTLKAAK 191
Cdd:PTZ00251  111 V-GVAMGLFSISKVPEFGDTFFLIMGGKKLPFLSWFHHVTIFLYAWMSYQQGSSIWICAAAMNYFVHSIMYFYFALSEAG 189
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2411765240 192 VKS-PSWFPMLVTSLQILQM----FIGATVCILAYIWRQEKGCH-TTEEHFFWSFILYATYFVLFAKFFHQNYIIPK 262
Cdd:PTZ00251  190 FKKlVKPFAMYITLLQITQMvgglFVSGYVIVQKLTKGDPKGCSgTTMATARGQLMIYIFNFYLFSEMFVKGYVLPR 266
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH