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Conserved domains on  [gi|2327202330|ref|XP_051694301|]
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alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 isoform X2 [Oryctolagus cuniculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29 super family cl45931
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 204-515 0e+00

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


The actual alignment was detected with superfamily member cd23973:

Pssm-ID: 480271  Cd Length: 309  Bit Score: 534.72  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 204 CPDSIKVRAARSPWLRSLFLPNLTLFLDSGHFNQSEWDRLEHFGPPFGFMELNHSLVQKVVAHFPPVPQQQLLlASNPPG 283
Cdd:cd23973     1 CPTSVRSKAAKSDWFKKLFLPNITLFLDKDHFNMSEWDRLEHFNPPFGFMGLNYTLVKEVVELIPKPKEQQLL-ALSPPG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 284 GSQCITCAVVGNGGILNNSKVGQEIDSHDYVFRLSGAVIKGYEQDVGTRTSFYGFTAFSVTQSLLILGSRGFQSVPVGKD 363
Cdd:cd23973    80 GDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTAHSITSSLMILQKRGFKNIPQDKD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 364 IRYLHFLEGTRDFEWLEALLQNQTLAKKNLFwfRRRPQEAFKEALTLDKYLLLHPDFLRYMKNRFLRSKTLDTAHWRIYR 443
Cdd:cd23973   160 IKYILFPEGPRDYQWLEALLKNKTIPSGAYY--GRRPRSYFSGDFTEDKYLVLHPDFLRYVKNRFLRSKTLKGKYWAIYR 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2327202330 444 PTTGALLLLTALHLCDKVSAYGFITEGHERFSDHYYDKTWKKLIFYINHDFKLERDVWKRLHDEGLIRLFQR 515
Cdd:cd23973   238 PTTGAFLLLTALHLCDTVSAYGFITEDYRKYPDHYYDKKKTKLVFYINHDFRLEKKLWKRLHDEKIIKLYQR 309
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 2-174 1.53e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 1.53e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330    2 PQAEAVLEGgtldPRHPA--------GDSVRTEPTKAPPEQRRHAPSPAatasaksqagdrneadTVSPPGQAAARVSN- 72
Cdd:PHA03247  2674 AQASSPPQR----PRRRAarptvgslTSLADPPPPPPTPEPAPHALVSA----------------TPLPPGPAAARQASp 2733

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330   73 -QTKAPTTKTAPGTKTTKGSRDPTRRP--TASKSAVVKPQGRAGTTAKRLVPPSQGKPKTTATTTPAAATAktrkSGATT 149
Cdd:PHA03247  2734 aLPAAPAPPAVPAGPATPGGPARPARPptTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDP----ADPPA 2809

                          170       180
                   ....*....|....*....|....*..
gi 2327202330  150 VAVAPAKKVPVT--PAPAQPPSTRGTP 174
Cdd:PHA03247  2810 AVLAPAAALPPAasPAGPLPPPTSAQP 2836
 
Name Accession Description Interval E-value
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 204-515 0e+00

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 534.72  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 204 CPDSIKVRAARSPWLRSLFLPNLTLFLDSGHFNQSEWDRLEHFGPPFGFMELNHSLVQKVVAHFPPVPQQQLLlASNPPG 283
Cdd:cd23973     1 CPTSVRSKAAKSDWFKKLFLPNITLFLDKDHFNMSEWDRLEHFNPPFGFMGLNYTLVKEVVELIPKPKEQQLL-ALSPPG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 284 GSQCITCAVVGNGGILNNSKVGQEIDSHDYVFRLSGAVIKGYEQDVGTRTSFYGFTAFSVTQSLLILGSRGFQSVPVGKD 363
Cdd:cd23973    80 GDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTAHSITSSLMILQKRGFKNIPQDKD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 364 IRYLHFLEGTRDFEWLEALLQNQTLAKKNLFwfRRRPQEAFKEALTLDKYLLLHPDFLRYMKNRFLRSKTLDTAHWRIYR 443
Cdd:cd23973   160 IKYILFPEGPRDYQWLEALLKNKTIPSGAYY--GRRPRSYFSGDFTEDKYLVLHPDFLRYVKNRFLRSKTLKGKYWAIYR 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2327202330 444 PTTGALLLLTALHLCDKVSAYGFITEGHERFSDHYYDKTWKKLIFYINHDFKLERDVWKRLHDEGLIRLFQR 515
Cdd:cd23973   238 PTTGAFLLLTALHLCDTVSAYGFITEDYRKYPDHYYDKKKTKLVFYINHDFRLEKKLWKRLHDEKIIKLYQR 309
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 229-509 3.84e-89

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 274.10  E-value: 3.84e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 229 FLDSGHFNQSEWDRLEHFGPPFgfmelnhSLVQKVVahfppvpqqQLLLASNPPGGSQCITCAVVGNGGILNNSKVGQEI 308
Cdd:pfam00777   1 FLTKENFPLGEWIRYSEWWLPF-------TVTEELL---------ELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEI 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 309 DSHDYVFRLSGAVIKGYEQDVGTRTSFYGFTAFSVTQSLliLGSRGFqSVPVGKDIRYLHFLEGTRDFEWLEALLQNQTL 388
Cdd:pfam00777  65 DSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIDSK--YGNLGF-SHPRDPFVEFVLVPFKGRDLLWLPAFLTKGNV 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 389 akkNLFWFRRRPQEAFKEALTLDKYLLLHPDFLRYMKNRFLRSKTLdtahwRIYRPTTGALLLLTALHLCDKVSAYGFIT 468
Cdd:pfam00777 142 ---SRSLRVLYTLKEVKIPVDPDKVLFLHPDFLRYVANFWLRSHGL-----KGRRPSTGLLMLSLALHLCDEVSLYGFGP 213

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2327202330 469 -EGHERFSDHYYDK-TWKKLIFYINHDFKLERDVWKRLHDEGL 509
Cdd:pfam00777 214 fLDSRGNSHHYYDNvLMKKGGFYGVHDMPFEFKLLQKLHKEGV 256
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2-174 1.53e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 1.53e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330    2 PQAEAVLEGgtldPRHPA--------GDSVRTEPTKAPPEQRRHAPSPAatasaksqagdrneadTVSPPGQAAARVSN- 72
Cdd:PHA03247  2674 AQASSPPQR----PRRRAarptvgslTSLADPPPPPPTPEPAPHALVSA----------------TPLPPGPAAARQASp 2733

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330   73 -QTKAPTTKTAPGTKTTKGSRDPTRRP--TASKSAVVKPQGRAGTTAKRLVPPSQGKPKTTATTTPAAATAktrkSGATT 149
Cdd:PHA03247  2734 aLPAAPAPPAVPAGPATPGGPARPARPptTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDP----ADPPA 2809

                          170       180
                   ....*....|....*....|....*..
gi 2327202330  150 VAVAPAKKVPVT--PAPAQPPSTRGTP 174
Cdd:PHA03247  2810 AVLAPAAALPPAasPAGPLPPPTSAQP 2836
 
Name Accession Description Interval E-value
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 204-515 0e+00

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 534.72  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 204 CPDSIKVRAARSPWLRSLFLPNLTLFLDSGHFNQSEWDRLEHFGPPFGFMELNHSLVQKVVAHFPPVPQQQLLlASNPPG 283
Cdd:cd23973     1 CPTSVRSKAAKSDWFKKLFLPNITLFLDKDHFNMSEWDRLEHFNPPFGFMGLNYTLVKEVVELIPKPKEQQLL-ALSPPG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 284 GSQCITCAVVGNGGILNNSKVGQEIDSHDYVFRLSGAVIKGYEQDVGTRTSFYGFTAFSVTQSLLILGSRGFQSVPVGKD 363
Cdd:cd23973    80 GDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTAHSITSSLMILQKRGFKNIPQDKD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 364 IRYLHFLEGTRDFEWLEALLQNQTLAKKNLFwfRRRPQEAFKEALTLDKYLLLHPDFLRYMKNRFLRSKTLDTAHWRIYR 443
Cdd:cd23973   160 IKYILFPEGPRDYQWLEALLKNKTIPSGAYY--GRRPRSYFSGDFTEDKYLVLHPDFLRYVKNRFLRSKTLKGKYWAIYR 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2327202330 444 PTTGALLLLTALHLCDKVSAYGFITEGHERFSDHYYDKTWKKLIFYINHDFKLERDVWKRLHDEGLIRLFQR 515
Cdd:cd23973   238 PTTGAFLLLTALHLCDTVSAYGFITEDYRKYPDHYYDKKKTKLVFYINHDFRLEKKLWKRLHDEKIIKLYQR 309
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 204-514 2.52e-128

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 375.83  E-value: 2.52e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 204 CPDSIKVRAARSPWLRSLFLPNLTLFLDSGHFNQSEWDRLEHFGPPFGFMELNHSLVQKVVAHFPPVPQQQLLlaSNPPG 283
Cdd:cd23964     1 CPSSLRKKLQKSPWFRERFIPDIKVLLDSEDFNPEEYNRLSHYKLPFGWGGLNREVVERLLRNLNLTSSRYMF--VLRGG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 284 GSQCITCAVVGNGGILNNSKVGQEIDSHDYVFRLSGAVIKGYEQDVGTRTSFYGFTAFSVTQSLLilgsrgfQSVPVGKD 363
Cdd:cd23964    79 RPRCIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPESLHNSLL-------KHVPQDKD 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 364 IRYLHFLEGTRDFEWLEALLQNQTLAKKNLfwFRRRPQEAFKEALTLDKYLLLHPDFLRYMKNRFLRSKTldtahwrIYR 443
Cdd:cd23964   152 TKYLFIPFKIRDYDYLDAVLSGKPVPDGCD--KGKRPPPLFGPKLNATNVRLLHPDFIRYLFNRWLNSST-------SYR 222

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2327202330 444 PTTGALLLLTALHLCDKVSAYGFITegHERFSDHYYDKTWKKLI-FYINHDFKLERDVWKRLHDEGLIRLFQ 514
Cdd:cd23964   223 PTTGALMLLTALHTCDQVSVYGFGY--DPRFSLHYYDKTFVKFTvFYANHDFTNERKLWRKLHEEGIINLYR 292
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 204-515 1.68e-97

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 297.51  E-value: 1.68e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 204 CPDSIKVRAARSPWLRSLFLPNLTLFLDSGHFNQSEWDRLEHFGPPFGFMELNHSLVQKVVAHFPPVPQQQLLLASNPPG 283
Cdd:cd23972     1 CPHSLHLRIQRDPHFRGLFNFDIPVLLWGQHFTPALWDRLSQRKVPYGWKGLSHQVVASTLSLLNDSANAKLFFPRDTPG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 284 GsqCITCAVVGNGGILNNSKVGQEIDSHDYVFRLSGAVIKGYEQDVGTRTSFYGFTAFSVTQSLLILGSRGFQSVPVGKD 363
Cdd:cd23972    81 K--CIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTSFYGFTVNTMKNSLISYWNLGFTRTPQGQD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 364 IRYLHFLEGTRDFEWLEALLQN----QTLAKKNlfwfrrRPQEAFKEALTLDKYLLLHPDFLRYMKNRFLRSKTLDTAHW 439
Cdd:cd23972   159 LQYIFIPSDIRDYVMLRSAILGvpvpEGLDKGD------RPHKYFGPEASAKKFKLLHPDFISYLTDRFLKSKLLNTHYG 232

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2327202330 440 RIYRPTTGALLLLTALHLCDKVSAYGFITEGHERFSDHYYDKTWKKLIFYINHDFKLERDVWKRLHDEGLIRLFQR 515
Cdd:cd23972   233 HLYMPSTGALMLLTALHTCDQVSAYGFITSNYWKFSDHYYERKKKPLVFYANHDMLLEAALWRRLHKAGILQLYQR 308
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 204-514 3.54e-95

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 291.66  E-value: 3.54e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 204 CPDSIKVRAARSPWlRSLFLPNLTLFLDSGHFNQSEWDRLEHFGPPFGFMELNHSLVQKVVAHFPPVPQQQLL-LASNPP 282
Cdd:cd23974     1 CPNGIRKRLANTEF-SGKFLENIPVLQWAKHATLSEYQRLKRYAGAHGWQEVDWDVLKDALNLLNSSANGQMFdWWDRPN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 283 GGSQCITCAVVGNGGILNNSKVGQEIDSHDYVFRLSGAVIKGYEQDVGTRTSFYGFTAFSVTQSLLILGSRGFQSVPVGK 362
Cdd:cd23974    80 GRSPCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFSTNTLMNSLRAYAGVGFNGPPQSK 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 363 DIRYLHFLEGTRDFEWLEALLQNQTLAK---KNlfwfrRRPQEAFKEALTLDKYLLLHPDFLRYMKNRFLRSKTLDTAHW 439
Cdd:cd23974   160 ETRYIFLPDHDRDYLLVKAALTHTPIDRgrdKS-----KRPSKYFGKDVTAEKFKIYHPDFIRYLRNRFLWSPILNTKQR 234

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2327202330 440 RIYRPTTGALLLLTALHLCDKVSAYGFITEGHERFSDHYYDKTWKKLIFYINHDFKLERDVWKRLHDEGLIRLFQ 514
Cdd:cd23974   235 DIYRPSTGAVMLLAALHTCDQVSAYGFMTPDYGKYSDHYYDKTYHKVVFYANHDLRLEMQLWQKLHKAGLIKLYM 309
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 229-509 3.84e-89

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 274.10  E-value: 3.84e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 229 FLDSGHFNQSEWDRLEHFGPPFgfmelnhSLVQKVVahfppvpqqQLLLASNPPGGSQCITCAVVGNGGILNNSKVGQEI 308
Cdd:pfam00777   1 FLTKENFPLGEWIRYSEWWLPF-------TVTEELL---------ELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEI 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 309 DSHDYVFRLSGAVIKGYEQDVGTRTSFYGFTAFSVTQSLliLGSRGFqSVPVGKDIRYLHFLEGTRDFEWLEALLQNQTL 388
Cdd:pfam00777  65 DSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIDSK--YGNLGF-SHPRDPFVEFVLVPFKGRDLLWLPAFLTKGNV 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 389 akkNLFWFRRRPQEAFKEALTLDKYLLLHPDFLRYMKNRFLRSKTLdtahwRIYRPTTGALLLLTALHLCDKVSAYGFIT 468
Cdd:pfam00777 142 ---SRSLRVLYTLKEVKIPVDPDKVLFLHPDFLRYVANFWLRSHGL-----KGRRPSTGLLMLSLALHLCDEVSLYGFGP 213

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2327202330 469 -EGHERFSDHYYDK-TWKKLIFYINHDFKLERDVWKRLHDEGL 509
Cdd:pfam00777 214 fLDSRGNSHHYYDNvLMKKGGFYGVHDMPFEFKLLQKLHKEGV 256
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 290-504 6.29e-34

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 126.71  E-value: 6.29e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 290 CAVVGNGGILNNSKVGQEIDSHDYVFRLSGAVIKGYEQDVGTRTSFYgFTAFSVTQSLLILGSRGFQSVPVGKDIRYLHF 369
Cdd:cd19952     1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFR-VLNSKWAGFYLRGPRCGCHPLPLEEEVVLILS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 370 LEGTRDFEWleallqnqtlakknLFWFRRRPQEAfkealtldKYLLLH--PDFLRYMKNRFLRSKTLDTAHWRiyRPTTG 447
Cdd:cd19952    80 RAAAADFKR--------------LKRRKKRHDNA--------VLLLTDpaPDLLSYVRKRLEKLGLKSFFGGN--APSSG 135

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2327202330 448 ALLLLTALHLCDKVSAYGFI--TEGHERFSDHYYDKTwKKLIFYINHDFKLERDVWKRL 504
Cdd:cd19952   136 LLAVLLALQLCDSVDLYGFGvdSGHAPKVPYHYYDLV-EAEEGTAVHSFDLEAELLRAL 193
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 259-514 1.06e-29

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 117.77  E-value: 1.06e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 259 LVQKVVAHFPPVPQQQlllasnPPGGSQCITCAVVGNGGILNNSKVGQEIDSHDYVFRLSGAVIKGYEQDVGTRTS---F 335
Cdd:cd23966    55 VLEKLFQVVPGENPYR------TRDPNRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTThhfM 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 336 YGFTAFSVTQSL-LILgsrgfqsVPvgkdirylhFleGTRDFEWLEALLQNQTLAKKnlfWFRRRPQ-EAFKealtlDKY 413
Cdd:cd23966   129 YPESAVDLDPGVhLVL-------VP---------F--KVLDLQWLISALTTGEITRT---YTPVKRFiKADK-----DKV 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 414 LLLHPDFLRYMKNRFLRSKtldtAHWriyrPTTGALLLLTALHLCDKVSAYGFITEGHERFsDHYYDKTWKKLIFYIN-- 491
Cdd:cd23966   183 LVINPAFIKYVHDNWTEHH----GRY----PSTGFLALIFALHICDEVSVFGFGADSKGNW-HHYWEKNRSAGAFRKTgv 253

                         250       260
                  ....*....|....*....|...
gi 2327202330 492 HDFKLERDVWKRLHDEGLIRLFQ 514
Cdd:cd23966   254 HDADFESDIIKKLAKEGKIRVYR 276
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 289-512 7.78e-26

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 106.58  E-value: 7.78e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 289 TCAVVGNGGILNNSKVGQEIDSHDYVFRLSGAVIKGYEQDVGTRTSfygFTafSVTQSLLILGSRGFQsvpvgKDIRYLH 368
Cdd:cd23963    65 TCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTN---LT--TLNPSILKRRYNSLK-----KNRDRDK 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 369 FLEGTRDFE----WLEAllqnqtlakknlFWFRRRPQEAFKEALTLDKY------LLLHPDFL----RYMKNRFLRSK-- 432
Cdd:cd23963   135 FLNRLKEYNgsilWYPK------------FSFKSSTNLLLKAARALKKNglnltvVYSNPEHFlavqKFWKRRGLEKRps 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 433 ------TLDTAHwriyrpttgalllltalhlCDKVSAYGF----ITEGHERFSDHYYDK-TWKKliFYINHDFKLERDVW 501
Cdd:cd23963   203 tglylvSLALTF-------------------CDEIHLYGFwpfpTDPNGRPVPYHYYDDlSPST--KNKVHNMPEEFKLL 261

                         250
                  ....*....|.
gi 2327202330 502 KRLHDEGLIRL 512
Cdd:cd23963   262 RELHKKGVLKL 272
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 287-504 7.40e-22

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 93.51  E-value: 7.40e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 287 CITCAVVGNGGILNNSKVGQEIDSHDYVFRLSGAVIKGYEQDVGTRTSF---YGFTAFsvtqsllilgsrgFQSVPVGKD 363
Cdd:cd23967     2 CRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFrmfYPESAF-------------RDPEEYDSD 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 364 IRYLHFLEGTRDFEWLEALLQNQTLaKKNLFWFRRRPQEAFKEAltlDKYLLLHPDFLR-------YMKNRFLRSKTldt 436
Cdd:cd23967    69 WLLVLVPFKSMDLLWLQAVIKGKKP-NGKGGFWKKIATSVPKPP---KKIRILNPYILQeaafdliGLPMNGKQGKN--- 141

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2327202330 437 ahwriyRPTTGALLLLTALHLCDKVSAYGFiteGHErFSD-----HYYDK-TWKKLIFYINHDFKLERDVWKRL 504
Cdd:cd23967   142 ------VPTTGIIAIVMALHYCDEVDIAGF---GYD-PSDpnaplHYYDSlTMKAIKRSWTHNVTKEKKYLKKL 205
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 274-512 3.46e-20

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 90.55  E-value: 3.46e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 274 QLLLASNPPGGSQCITCAVVGNGGILNNSKVGQEIDSHDYVFRLSGAVIKGYEQDVGTRTSFygftaFSVTQSLLILGSR 353
Cdd:cd23969    51 QLLPEVSPLKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNL-----TTMNPSVIPHAYG 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 354 GFQSVPV-GKDIRYLHFLEGTrdFEWLEALLQNQtlAKKNLFWFRrrpQEAFKEALTLdKYLLLHPDFLRYMKNRFLRSK 432
Cdd:cd23969   126 DLVNATDkEKFVERLRQLGDS--ILWIPAFVSKG--GEEHVQWTN---EIILKHKLNV-KTAYPPLRLNHAIRGYWLTTK 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 433 TldtahwRIYRPTTGALLLLTALHLCDKVSAYGF--ITEGH--ERFSDHYYDkTWKKLIFYINHDFKLERDVWKRLHDEG 508
Cdd:cd23969   198 F------RIKRPSTGLLMYTLATRFCDEIHLYGFypFSEDGngRAVKYHYYD-NRKYLTTARPHKMPEEFRALRSLHQRG 270


                  ....
gi 2327202330 509 LIRL 512
Cdd:cd23969   271 ALRL 274
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 287-504 5.61e-19

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 85.10  E-value: 5.61e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 287 CITCAVVGNGGILNNSKVGQEIDSHDYVFRLSGAVIKGYEQDVGTRTS---FYGFTAFSVTQ------SLLILGSrgFQS 357
Cdd:cd23982     2 CRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTirlFYPESAQFDPGiendpdTLLVLVP--FKP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 358 VpvgkdirylhflegtrDFEWLEALLQNQTLAKKnLFWfRRRPQEAFKEAltlDKYLLLHPDFLRYMKNRFLrskTLDTA 437
Cdd:cd23982    80 L----------------DFYWLYEILSNEKRVRK-GFW-KQPPRIWDANP---KQIRILNPYYTYVAATKLL---QVPGQ 135

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2327202330 438 HWRIYRPTTGALLLLTALHLCDKVS--AYGFITEGHERFSDHYYDKTWKKLIFYINHDFKLERDVWKRL 504
Cdd:cd23982   136 RKKKQKPTTGLLAITLALHLCDEVHiaGFGYPDNGNSNQPIHYYNQITLKSMANSGHNLNAEAQAIQRL 204
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 289-512 6.42e-17

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 81.29  E-value: 6.42e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 289 TCAVVGNGGILNNSKVGQEIDSHDYVFRLSGAVIKGYEQDVGTRTSFYGFTAfsvtqSLLilgSRGFQSVPVGKDIRylH 368
Cdd:cd23970    70 TCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNP-----SIL---EKYYNNLLTIQDRN--N 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 369 FLEGTRDFE----WLEAL-LQNQTLAKKNLFWFrrrpqeaFKEALTLDKYLLLHP-DFLRYMkNRFLRSKTLDTahwriY 442
Cdd:cd23970   140 FFLSLKKLDgailWIPAFfFHTSATVTRTLVDF-------FVEHRGQLKVQLAWPgNIMQHV-NRYWKTKHLSP-----K 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 443 RPTTGALLLLTALHLCDKVSAYGF----ITEGHERFSDHYYDK-------TWKKLifyinHDFKLERDVWKRLHDEGLIR 511
Cdd:cd23970   207 RLSTGILMYTLASAICEEIHLYGFwpfgFDPTGTPLPYHYYDKkgtkfttKWQES-----HQLPAEFVLLYKMHGAGVLK 281


                  .
gi 2327202330 512 L 512
Cdd:cd23970   282 L 282
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 289-505 8.76e-17

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 80.39  E-value: 8.76e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 289 TCAVVGNGGILNNSKVGQEIDSHDYVFRLSGAVIKGYEQDVGTRTSfygftaFSVTQSlLILGSRGFQSVpvgKDIRYLH 368
Cdd:cd23968    47 TCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTT------LRLINS-QILSKPEFNFL---TDPLYRN 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 369 FLEGTRDFE-WLEALLQNQTLAKKNLF-----WFRRRPQEAFkealtldkYlLLHPDFLRYMKNrFLRSKTldtaHWRIY 442
Cdd:cd23968   117 VTLLVWDPSsYNVNLEKWYKKPDFDFFpnyikYRRRHPEEPF--------Y-LIDPRFLWRLWD-ILQEYT----PEKIK 182

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2327202330 443 R--PTTGALLLLTALHLCDKVSAYGFITEghERFSD--HYYDKTWKKL-IFYINHDFKLERDVWKRLH 505
Cdd:cd23968   183 PnpPSSGFIGIVLMLHLCDWVDVYEYVPS--VRQTDrcHYYDVEKDLAcTLGAWHPLAAEKLLVRHLN 248
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 274-512 1.64e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 79.98  E-value: 1.64e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 274 QLLLASNPPGGSQCITCAVVGNGGILNNSKVGQEIDSHDYVFRLSGAVIKGYEQDVGTRTSFYGFTAfSVTQsllilgsR 353
Cdd:cd23987    51 ELLPRTSPLKNKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNP-SVVQ-------R 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 354 GFQSVpvgkdirylhflegtRDFEWLEALLQNQTLAKKNLFWFRRRPQEAFKEALT-LDKYLLLHPDFLR--YMKNRFL- 429
Cdd:cd23987   123 AFEDL---------------VNETWKEKFLQRLQSLNGSILWIPAFMAKGGEERVEwVNDLILKHHINVRtaYPSLRLLh 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 430 --RSKTLdTAHWRIYRPTTGALLLLTALHLCDKVSAYGFITEGHERFSD----HYYDK-TWKKLIFYINHDFKLERDVWK 502
Cdd:cd23987   188 avRGYWL-TNKVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQNpvkyHYYDSlKYGYTSQASPHTMPLEFKALK 266

                         250
                  ....*....|
gi 2327202330 503 RLHDEGLIRL 512
Cdd:cd23987   267 NLHQQGALKL 276
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 287-480 2.14e-16

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 77.86  E-value: 2.14e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 287 CITCAVVGNGGILNNSKVGQEIDSHDYVFRLSGAVIKGYEQDVGTRTSF---YGFTAFSV---TQSLLILGSRGFQSVpv 360
Cdd:cd23983     2 CRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIrmtYPEGAPKSeqeYDPTSLFVAVLFKSV-- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 361 gkdirylhflegtrDFEWLEALLQNQTLAKKNLFWFRRRPQEafKEALTLDKYLLLHPDFLRYMKNRFL-----RSKTLD 435
Cdd:cd23983    80 --------------DFAWLKAMVKKEPLSFWSRLFFWKEVAD--SIPLKPSQFRILNPLIIKETALDILqypepQSRLWG 143

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 2327202330 436 tahWRIYRPTTGALLLLTALHLCDKVSAYGFITE-GHERFSDHYYD 480
Cdd:cd23983   144 ---WDKNVPTLGVTAVVLATHLCDEVSLAGFGYDlSQPHAPLHYYD 186
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 289-512 6.03e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 78.07  E-value: 6.03e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 289 TCAVVGNGGILNNSKVGQEIDSHDYVFRLSGAVIKgYEQDVGTRTSFygftafsVTQSLLILgsrgfqsvpvgkdIRYLH 368
Cdd:cd23971    66 TCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVGSKTNL-------VTANPSIL-------------REKFH 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 369 FLEGTRDfEWLEALLQ-NQTLAKKNLFWFRRRPQEAFKEALTLD------KYLLLHPDFLRYMkNRFLRSKTLdtahwRI 441
Cdd:cd23971   125 NLKKRRR-PFVERMKVyGNALLLLPAFSYTSNTEPSLRALYTLEdfgspqKVLFFNPEYLRNL-SRYWKSKGL-----KA 197

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2327202330 442 YRPTTGALLLLTALHLCDKVSAYGF----ITEGHERFSDHYYDKTWKKLIFyinHDFKLERDVWKRLHDEGLIRL 512
Cdd:cd23971   198 RRLSTGLMLVSAALELCENVHLYGFwpfsTDLDGNPISHHYYDNVLPKKGV---HAMPEEFLRYLKLHSQGVLRL 269
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 287-479 1.20e-14

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 72.86  E-value: 1.20e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 287 CITCAVVGNGGILNNSKVGQEIDSHDYVFRLSGAVIKGYEQDVGTRTSF---YGFTAFSvtqsllilgsrgfQSVPVGKD 363
Cdd:cd23984     2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFrlcYPESIFS-------------DPSHYDPN 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 364 IRYLHFLEGTRDFEWLEALLQNQtlaKKNLFWFRRRPqeAFKEALTLDKYLLLHPDFLRYMKNRFLR-SKTLDTAHWRIY 442
Cdd:cd23984    69 TTVVLIPFKPHDLRWLLDLLMGK---KVSAKGFWKKP--ALNLIYKPNQIRILNPFILRIAAYELLHfPKRFPKEKKPKH 143

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 2327202330 443 rPTTGALLLLTALHLCDKVSAYGFitegHERFSD-----HYY 479
Cdd:cd23984   144 -PTTGIIAITLALHICNEVHIAGF----KYDFSNlnstlHYY 180
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 275-512 1.28e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 74.02  E-value: 1.28e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 275 LLLASNPPGGSQCITCAVVGNGGILNNSKVGQEIDSHDYVFRLSGAVIKG-YEQDVGTRTSFygftafsVTQSLLILgSR 353
Cdd:cd23991    52 MFPKSQPFRGYPYKQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNL-------VTANPSII-SI 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 354 GFQSVPVGKDIrylhFLEGTRDFewleallqNQTLAKKNLFWFRRRPQEAFKEALTLDKY------LLLHPdflRYMKN- 426
Cdd:cd23991   124 KYAKLNERRKP----FLETVSVY--------GDAFLLLPAFSYRSNTALSFKVYYTLEDFkakqkvIFFHP---IYLKHl 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 427 -RFLRSKTLdtahwRIYRPTTGALLLLTALHLCDKVSAYGF-----ITEGhERFSDHYYDKTWKKLIFyinHDFKLERDV 500
Cdd:cd23991   189 aQFWRSKGV-----QVYRLSTGLMITSAALELCEEVKLYGFwpfskNTEG-KPISHHYYDNQLPKPGF---HSMPKEFYQ 259

                         250
                  ....*....|..
gi 2327202330 501 WKRLHDEGLIRL 512
Cdd:cd23991   260 LLQLHSKGILKL 271
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 240-514 5.75e-14

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 72.22  E-value: 5.75e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 240 WDRLEHFGPPFGFMELNHSLVQKVVAHFPPVPQQQLLlasnppggsQCITCAVVGNGGILNNSKVGQEIDSHDYVFRLSG 319
Cdd:cd23980    43 WLRLQREKKPKNLNDTIRELFQVVPGNVDPLLEKRLV---------SCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNK 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 320 AVIKGYEQDVGTRTSFYGFTAFSVTQsllilgsrgfqsvpVGKDIRYLHFLEGTRDFEWLEALLQNQTLAkknlFWFRRR 399
Cdd:cd23980   114 APTEGFEADVGSKTTHHFVYPESFRE--------------LAQNVSMILVPFKTLDLEWVISATTTGTIS----HTYVPV 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 400 PQeafKEALTLDKYLLLHPDFLRYMKNRFLRSktldtaHWRIyrPTTGALLLLTALHLCDKVSAYGFITEGHERFSdHYY 479
Cdd:cd23980   176 PR---KIKVKKEKILIYHPAFIKYVFDRWLQG------HGRY--PSTGILSVIFSLHVCDEVDLYGFGADSKGNWH-HYW 243

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2327202330 480 DKTWKKLIFYIN--HDFKLERDVWKRLHDEGLIRLFQ 514
Cdd:cd23980   244 ENNPSAGAFRKTgvHDGDFESNVTTILASINKIRIFK 280
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 287-420 2.50e-13

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 69.18  E-value: 2.50e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 287 CITCAVVGNGGILNNSKVGQEIDSHDYVFRLSGAVIKGYEQDVGTRTsfygftafsvtqSLLILGSRGFQSVPVGKDIRY 366
Cdd:cd23981     2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKT------------TLRITYPEGAIQKPEQYEKDS 69

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2327202330 367 LHFLEGTR--DFEWLEALLQNQTLAKKNLFW---FRRRPQEAfKEALTLDKYLLLHPDF 420
Cdd:cd23981    70 LFVLAGFKwqDFKWLKYIVYKEKVSASDGFWksvATRVPREP-HEIRILNPYFIQEAAF 127
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 227-335 3.30e-13

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 69.74  E-value: 3.30e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 227 TLFLDSGHFNQSEWdrlEHFGPPFGFMElnhslvqkVVAHFPpvpqqqlllasnppggsqciTCAVVGNGGILNNSKVGQ 306
Cdd:cd23985    16 MLEGTDFPFNTSEW---EGYLPKKSLRE--------EVGPLG--------------------RCAVVSSAGSLKSSGLGR 64

                          90       100
                  ....*....|....*....|....*....
gi 2327202330 307 EIDSHDYVFRLSGAVIKGYEQDVGTRTSF 335
Cdd:cd23985    65 EIDSHDAVLRFNGAPTAGFQQDVGTKTTI 93
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 257-512 5.61e-13

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 69.09  E-value: 5.61e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 257 HSLVQKVVAHFPPVPQQQLLLASnppggsqcitCAVVGNGGILNNSKVGQEIDSHDYVFRLS-GAVIKGYEQDVGTRTSF 335
Cdd:cd23989    43 HTVDNETYSLFPQDTPLQLPLKK----------CSVVGNGGILKNSGCGQQIDRADFVMRCNlPPLSREYTDDVGTKTQL 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 336 ygftafsVTQSLLILGSRgFQSvpvgKDIRYLHFLEGTRDFewleallqNQTLAKKNLFWFRRRPQEAFKEALTLDKY-- 413
Cdd:cd23989   113 -------VTANPSIIDKR-FQN----LLWSRKSFVESMKVY--------GRSYIYMPAFSMKTGTDPSLRVYYTLADVga 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 414 ----LLLHPDFLR----YMKNRFLRSKTLDTAHWRIyrpttgalllLTALHLCDKVSAYG---FITEGHERF-SDHYYDK 481
Cdd:cd23989   173 nqtvLFANPNFLRnvgkFWKSKGVHAKRLSTGLFLV----------SAALGLCEEVTIYGfwpFSVDLDERTiSHHYYDN 242

                         250       260       270
                  ....*....|....*....|....*....|..
gi 2327202330 482 TWKKLIFY-INHDFKlerDVWkRLHDEGLIRL 512
Cdd:cd23989   243 VLPDSGFHaMPEEFL---QLW-HLHKSGVLRM 270
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 289-512 1.01e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 68.44  E-value: 1.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 289 TCAVVGNGGILNNSKVGQEIDSHDYVFRLSGAVIKGYEQDVGTRTSFYGFTAfSVTQsllilgsRGFQSVPVGKD----I 364
Cdd:cd23988    66 TCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNP-SVVQ-------RAFGGFRNESDrekfV 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 365 RYLHFLE-------------GTRDFEWLEALLQNQTLAKKNLFWFRRrpqeafkealtldkylLLHPdflryMKNRFLRS 431
Cdd:cd23988   138 HRLSMLNdsvlwipafmvkgGEKHVEWVNALILKNKLKVRTAYPSLR----------------LIHA-----VRGYWLTN 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 432 KTldtahwRIYRPTTGALLLLTALHLCDKVSAYGFITEGHERFSD----HYYDKTwkKLIFYIN---HDFKLERDVWKRL 504
Cdd:cd23988   197 KV------NIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDANGNpvkyHYYDDL--KYRYFSNagpHRMPLEFKTLNVL 268


                  ....*...
gi 2327202330 505 HDEGLIRL 512
Cdd:cd23988   269 HNRGALKL 276
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 287-335 7.62e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 64.96  E-value: 7.62e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2327202330 287 CITCAVVGNGGILNNSKVGQEIDSHDYVFRLSGAVIKGYEQDVGTRTSF 335
Cdd:cd23965     1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTI 49
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 266-334 1.11e-11

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 65.24  E-value: 1.11e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2327202330 266 HFPPVPQQQLllasNPPGGSqciTCAVVGNGGILNNSKVGQEIDSHDYVFRLSGAVIKGYEQDVGTRTS 334
Cdd:cd23986    35 YVPKIPLSKL----HLRGFR---SCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTT 96
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 285-514 2.19e-11

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 64.51  E-value: 2.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 285 SQCITCAVVGNGGILNNSKVGQEIDSHDYVFRLSGAVIKGYEQDVGTRTSFYgftaFSVTQSLLILGSR-GFQSVPVgkd 363
Cdd:cd23979    78 SRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHH----FMYPESAKNLPANvSFVLVPF--- 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330 364 irylhfleGTRDFEWLEALLQNQTLAkknlfwFRRRPQEAFKEaLTLDKYLLLHPDFLRYMKNRFlrsktldTAHWRIYr 443
Cdd:cd23979   151 --------KTLDLLWITSALSTGQIR------FTYAPVKQFLR-VDKDKVQIYNPAFFKYIHDRW-------TEHHGRY- 207

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2327202330 444 PTTGALLLLTALHLCDKVSAYGFITEG----HERFSDHYYDKTWKKLIFyinHDFKLERDVWKRLHDEGLIRLFQ 514
Cdd:cd23979   208 PSTGMLVLFFALHVCDEVNVYGFGADSrgnwHHYWENNRYAGEFRKTGV---HDADFEAHIIDMLAKAGKIKVYR 279
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 285-333 1.61e-09

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 58.69  E-value: 1.61e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2327202330 285 SQCITCAVVGNGGILNNSKVGQEIDSHDYVFRLS-GAVIKGYEQDVGTRT 333
Cdd:cd23990    62 SQFKKCAVVGNGGILKNSKCGREIDSADFVFRCNlPPISEKYVRDVGVKT 111
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 287-334 1.21e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 52.56  E-value: 1.21e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2327202330 287 CITCAVVGNGGILNNSKVGQEIDSHDYVFRLSGAVIKGYEQDVGTRTS 334
Cdd:cd23977     1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSS 48
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 287-334 1.48e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 52.24  E-value: 1.48e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2327202330 287 CITCAVVGNGGILNNSKVGQEIDSHDYVFRLSGAVIKGYEQDVGTRTS 334
Cdd:cd23975     1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTT 48
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 277-335 2.70e-06

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 48.71  E-value: 2.70e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2327202330 277 LASNPPGGSQCITCAVVGNGGILNNSKVGQEIDSHDYVFRLSGAVIKGYEQDVGTRTSF 335
Cdd:cd23976     5 IIDHKPLKMHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSL 63
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 287-335 3.62e-05

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 45.23  E-value: 3.62e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2327202330 287 CITCAVVGNGGILNNSKVGQEIDSHDYVFRLSGAVIKGYEQDVGTRTSF 335
Cdd:cd23978     1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTL 49
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2-174 1.53e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 1.53e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330    2 PQAEAVLEGgtldPRHPA--------GDSVRTEPTKAPPEQRRHAPSPAatasaksqagdrneadTVSPPGQAAARVSN- 72
Cdd:PHA03247  2674 AQASSPPQR----PRRRAarptvgslTSLADPPPPPPTPEPAPHALVSA----------------TPLPPGPAAARQASp 2733

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330   73 -QTKAPTTKTAPGTKTTKGSRDPTRRP--TASKSAVVKPQGRAGTTAKRLVPPSQGKPKTTATTTPAAATAktrkSGATT 149
Cdd:PHA03247  2734 aLPAAPAPPAVPAGPATPGGPARPARPptTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDP----ADPPA 2809

                          170       180
                   ....*....|....*....|....*..
gi 2327202330  150 VAVAPAKKVPVT--PAPAQPPSTRGTP 174
Cdd:PHA03247  2810 AVLAPAAALPPAasPAGPLPPPTSAQP 2836
PHA03255 PHA03255
BDLF3; Provisional
 49-174 1.03e-03

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 40.66  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330  49 SQAGDRNEADTVSPPGQAAARVS-NQTKAPTTKTAPGTKTTKGSRDPTR--------RPTASKSAVVKPQGRAGTTAKRL 119
Cdd:PHA03255   32 ASAGNVTGTTAVTTPSPSASGPStNQSTTLTTTSAPITTTAILSTNTTTvtstgttvTPVPTTSNASTINVTTKVTAQNI 111

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2327202330 120 VPPSQGKPKTT------ATTTPAAATAKTRKSGATTVAVAPAKK-----------VPVTPAPAQPPSTRGTP 174
Cdd:PHA03255  112 TATEAGTGTSTgvtsnvTTRSSSTTSATTRITNATTLAPTLSSKgtsnatkttaeLPTVPDERQPSLSYGLP 183
PHA03247 PHA03247
large tegument protein UL36; Provisional
 15-179 3.31e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 3.31e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330   15 PRHPAGDSVRT-EPTKAPPEQRRHAPSPAATASAKSQAGDRNEADTVSPPGQAAARVSNQTKAPTTKTAPGTKTTKGSrd 93
Cdd:PHA03247  2601 PVDDRGDPRGPaPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASS-- 2678

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330   94 PTRRPT--ASKSAVvkpqgraGTTAKRLVPPSQGKPKTTATTTPAAATAKTRKSGATTVAVAPAKKVPVTPAPAQPPSTR 171
Cdd:PHA03247  2679 PPQRPRrrAARPTV-------GSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATP 2751


                   ....*...
gi 2327202330  172 GTPRLKAA 179
Cdd:PHA03247  2752 GGPARPAR 2759
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 57-179 6.67e-03

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 38.78  E-value: 6.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327202330  57 ADTVSPPGQAAARVSNQTKAPTTKTAPgtkTTKGSRDPTRRPTASKSAVVKPQGRAGTTAKRLVPPSQGKPKTTATTTPA 136
Cdd:PTZ00436  230 AKAAAPPAKAAAAPAKAAAAPAKAAAP---PAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAAPAKAAAAP 306

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2327202330 137 AATAktrkSGATTVAVAPAKKVPVTPAPAQPPSTRGTPRLKAA 179
Cdd:PTZ00436  307 AKAA----AAPAKAAAPPAKAAAPPAKAATPPAKAAAPPAKAA 345
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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