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Conserved domains on  [gi|2308379641|ref|XP_050570942|]
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LOW QUALITY PROTEIN: rap1 GTPase-activating protein 1 [Cygnus atratus]

Protein Classification

GTPase-activating protein( domain architecture ID 10489639)

GTPase-activating protein functions as a GTPase activator for small GTPases, similar to Homo sapiens Rap1 GTPase-activating protein 2, a GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state

CATH:  3.40.50.11210|2.20.140.30
Gene Ontology:  GO:0051056|GO:0005096

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Rap_GAP pfam02145
Rap/ran-GAP;
199-378 7.72e-89

Rap/ran-GAP;


:

Pssm-ID: 460463  Cd Length: 179  Bit Score: 274.00  E-value: 7.72e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641 199 FGTTEESPAFAEFLDVLGQRVQLRDFKGFRGGLDVTHGQTGSESVYCHFRDKEIMFHVSTKLPYTEGDAQQLQRKRHIGN 278
Cdd:pfam02145   1 LSNEEGSPAYEEFLNLLGWLVELKGFKGYRGGLDTKNNTTGEYSYYWADRGTEIMFHVSTLMPTTENDPQQLEKKRHIGN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641 279 DIVAIVFQDENTPFVPDMIASNFLHAFVVVQLEQGGPQGTLYKVSVTARDDVPFFGPPLPDPAIFRKG--PEFQEFLltk 356
Cdd:pfam02145  81 DIVNIVFNESGGPFDPSTIKSQFNHVFIVVQPNLPDTDNTLYRVSVVRKDDVPPFGPLLPDPKIFSKDnlPEFVRFL--- 157

                         170       180
                  ....*....|....*....|..
gi 2308379641 357 LINAEYACYKAEKFAKLEERTR 378
Cdd:pfam02145 158 AINAERAALKSSSFAERLRRIR 179
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 448-582 2.95e-06

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 50.55  E-value: 2.95e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641  448 PGKSPSRRRPGPLGSRRSSAIGIESIQEAPPGRDGPAANTDGAGSAHSSPESRRHPDRTAARPRGPPASATPSPTPPGQR 527
Cdd:PHA03307   280 SRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPP 359

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2308379641  528 SPSAPPQVAQPWGVGGGGGGGERGHPWVLTAPPPTPPRSKSSWSGPPRPRARSRA 582
Cdd:PHA03307   360 ADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRP 414
 
Name Accession Description Interval E-value
Rap_GAP pfam02145
Rap/ran-GAP;
199-378 7.72e-89

Rap/ran-GAP;


Pssm-ID: 460463  Cd Length: 179  Bit Score: 274.00  E-value: 7.72e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641 199 FGTTEESPAFAEFLDVLGQRVQLRDFKGFRGGLDVTHGQTGSESVYCHFRDKEIMFHVSTKLPYTEGDAQQLQRKRHIGN 278
Cdd:pfam02145   1 LSNEEGSPAYEEFLNLLGWLVELKGFKGYRGGLDTKNNTTGEYSYYWADRGTEIMFHVSTLMPTTENDPQQLEKKRHIGN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641 279 DIVAIVFQDENTPFVPDMIASNFLHAFVVVQLEQGGPQGTLYKVSVTARDDVPFFGPPLPDPAIFRKG--PEFQEFLltk 356
Cdd:pfam02145  81 DIVNIVFNESGGPFDPSTIKSQFNHVFIVVQPNLPDTDNTLYRVSVVRKDDVPPFGPLLPDPKIFSKDnlPEFVRFL--- 157

                         170       180
                  ....*....|....*....|..
gi 2308379641 357 LINAEYACYKAEKFAKLEERTR 378
Cdd:pfam02145 158 AINAERAALKSSSFAERLRRIR 179
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 448-582 2.95e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 50.55  E-value: 2.95e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641  448 PGKSPSRRRPGPLGSRRSSAIGIESIQEAPPGRDGPAANTDGAGSAHSSPESRRHPDRTAARPRGPPASATPSPTPPGQR 527
Cdd:PHA03307   280 SRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPP 359

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2308379641  528 SPSAPPQVAQPWGVGGGGGGGERGHPWVLTAPPPTPPRSKSSWSGPPRPRARSRA 582
Cdd:PHA03307   360 ADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRP 414
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 451-574 5.18e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.14  E-value: 5.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641 451 SPSRRRPGPLGSRRSSAIGIESIQEAPPGRDGPAANTDGAGSAHSSPESRRHPDRTAARPRGPPASATPSPTPPGQRSPS 530
Cdd:pfam03154 145 SPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQST 224

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2308379641 531 APPQVAQPWGVGGGGGGGERGHPWVLTAPPPTPPRSKSSWSGPP 574
Cdd:pfam03154 225 AAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQ 268
 
Name Accession Description Interval E-value
Rap_GAP pfam02145
Rap/ran-GAP;
199-378 7.72e-89

Rap/ran-GAP;


Pssm-ID: 460463  Cd Length: 179  Bit Score: 274.00  E-value: 7.72e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641 199 FGTTEESPAFAEFLDVLGQRVQLRDFKGFRGGLDVTHGQTGSESVYCHFRDKEIMFHVSTKLPYTEGDAQQLQRKRHIGN 278
Cdd:pfam02145   1 LSNEEGSPAYEEFLNLLGWLVELKGFKGYRGGLDTKNNTTGEYSYYWADRGTEIMFHVSTLMPTTENDPQQLEKKRHIGN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641 279 DIVAIVFQDENTPFVPDMIASNFLHAFVVVQLEQGGPQGTLYKVSVTARDDVPFFGPPLPDPAIFRKG--PEFQEFLltk 356
Cdd:pfam02145  81 DIVNIVFNESGGPFDPSTIKSQFNHVFIVVQPNLPDTDNTLYRVSVVRKDDVPPFGPLLPDPKIFSKDnlPEFVRFL--- 157

                         170       180
                  ....*....|....*....|..
gi 2308379641 357 LINAEYACYKAEKFAKLEERTR 378
Cdd:pfam02145 158 AINAERAALKSSSFAERLRRIR 179
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 448-582 2.95e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 50.55  E-value: 2.95e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641  448 PGKSPSRRRPGPLGSRRSSAIGIESIQEAPPGRDGPAANTDGAGSAHSSPESRRHPDRTAARPRGPPASATPSPTPPGQR 527
Cdd:PHA03307   280 SRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPP 359

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2308379641  528 SPSAPPQVAQPWGVGGGGGGGERGHPWVLTAPPPTPPRSKSSWSGPPRPRARSRA 582
Cdd:PHA03307   360 ADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRP 414
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
391-629 3.41e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 50.23  E-value: 3.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641 391 GRSQamLGLGPDD---------------ERPDNGSATPGFFESFKSLLVPGSRrGRRGSAIGLGSVEEALLVPGKSPSRR 455
Cdd:PRK07003  334 GRGE--LGLAPDEyagftmtllrmlafePAVTGGGAPGGGVPARVAGAVPAPG-ARAAAAVGASAVPAVTAVTGAAGAAL 410

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641 456 RPGPLGSRRSSAigiesiQEAPPGRDGPAANTDGAGSAHSSPESRRHPDRTAARPRGPPASATPSPtppgqrsPSAPPQV 535
Cdd:PRK07003  411 APKAAAAAAATR------AEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQP-------PADSGSA 477

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641 536 AQPWGVGggggggerghpwvltapPPTPPRSKSSWSGPPRPRARSRAHPPNPGGPPPEEGPRRAPPPRRAARRFAPSPA- 614
Cdd:PRK07003  478 SAPASDA-----------------PPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPEARPPTPAAa 540

                         250
                  ....*....|....*.
gi 2308379641 615 -PVARVPGAEAIVPVL 629
Cdd:PRK07003  541 aPAARAGGAAAALDVL 556
PHA03247 PHA03247
large tegument protein UL36; Provisional
 401-643 1.93e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.01  E-value: 1.93e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641  401 PDDERPD----NGSATPGFFESFKSLLVPGSRRGRRGSAiglgsveeallvpgksPSRRRPgplgSRRSSAIGIESIQEA 476
Cdd:PHA03247  2619 PDTHAPDppppSPSPAANEPDPHPPPTVPPPERPRDDPA----------------PGRVSR----PRRARRLGRAAQASS 2678

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641  477 PPGRDGPAANTDGAGSAHSSPESRRHPDRTAARPRgPPASATPSPTPPGQRSPSAPPQVAQPWGVGGGGGGGERGHPWVL 556
Cdd:PHA03247  2679 PPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPH-ALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARP 2757

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641  557 TAPP-------PTPPRSKSSwsGPPRPRARSRAhppnpggPPPEEGPRRAPPPRRAARRFAPSPAPVARVPGAEAIVPVL 629
Cdd:PHA03247  2758 ARPPttagppaPAPPAAPAA--GPPRRLTRPAV-------ASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPL 2828

                          250
                   ....*....|....
gi 2308379641  630 SPQTAEKPLGSKWP 643
Cdd:PHA03247  2829 PPPTSAQPTAPPPP 2842
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 391-643 2.82e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 47.47  E-value: 2.82e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641  391 GRSQAMLGLGPDDERPDNGSATPGFFESFKSLLVPGSRRGRRGSAIGLGSVEEALLVPGKSPSRRRPGPLGSRRSSAIGI 470
Cdd:PHA03307   168 SSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGC 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641  471 ESIQEAPPGRDGPAANTDGAGSAHSSPESRRHPDRTAARPRGPPASATPSPTPPGQRSPSAPPQ-------------VAQ 537
Cdd:PHA03307   248 GWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSprasssssssresSSS 327

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641  538 PWGVGGGGGGGERGHPWVLTAPPPTPPRSkSSWSGPPRPRARSRAHPPNPGGPPPEEGPRRAPPPRRAARRFAPSPAPVA 617
Cdd:PHA03307   328 STSSSSESSRGAAVSPGPSPSRSPSPSRP-PPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGR 406

                          250       260       270
                   ....*....|....*....|....*....|....*
gi 2308379641  618 RVPGAEAIVPVLSPQTAEK---------PLGSKWP 643
Cdd:PHA03307   407 FPAGRPRPSPLDAGAASGAfyaryplltPSGEPWP 441
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 476-579 4.84e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 46.60  E-value: 4.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641 476 APPGrdGPAANTDGAGSAHSSPEsrrhPDRTAARPRGPPASATPSPTPPGQRSPSAPPQVAQPWGVGggggggerghpwv 555
Cdd:PRK14959  379 SAPS--GSAAEGPASGGAATIPT----PGTQGPQGTAPAAGMTPSSAAPATPAPSAAPSPRVPWDDA------------- 439

                          90       100
                  ....*....|....*....|....
gi 2308379641 556 ltapPPTPPRSksswSGPPRPRAR 579
Cdd:PRK14959  440 ----PPAPPRS----GIPPRPAPR 455
PHA03247 PHA03247
large tegument protein UL36; Provisional
 448-643 8.62e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 8.62e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641  448 PGKSPSRRRPGPLGSRRSSAIGIESIQEAPPGRDGPAANTDGAGSAHSSPESRRHPDRTAARPRGP------------PA 515
Cdd:PHA03247  2618 PPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPrrraarptvgslTS 2697

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641  516 SATPSPTPPGQRSPSAPPQVAQPWGVGGGGGGGERGHPWVLTAPPPTP-----------PRSKSSWSGPPRPRARSRAHP 584
Cdd:PHA03247  2698 LADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPagpatpggparPARPPTTAGPPAPAPPAAPAA 2777

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2308379641  585 PNPGGPPPEEGPRRAPPPRRAARRFAPSPAPVARVPGAEAIVPVLSPQTAEKPLGSKWP 643
Cdd:PHA03247  2778 GPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQP 2836
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 475-576 1.15e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 45.36  E-value: 1.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641 475 EAPPGRDGPAANTDGAGSAHSSPESRRHPDRTAARPRGPPASATPSPTPPGQRSPSAPPqVAQPWGVGGGGGGGERGHPW 554
Cdd:PRK07764  391 AGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAP-AGGAPSPPPAAAPSAQPAPA 469

                          90       100
                  ....*....|....*....|..
gi 2308379641 555 VLTAPPPTPPRSKSSWSGPPRP 576
Cdd:PRK07764  470 PAAAPEPTAAPAPAPPAAPAPA 491
PHA03247 PHA03247
large tegument protein UL36; Provisional
 472-620 1.71e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 1.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641  472 SIQEAPPGRDGPAANTD--GAGSAHSSPESRRHPDRTA----ARPRGPPASATPSPTPPGQRSPSA-----PPQVAQPWG 540
Cdd:PHA03247  2834 AQPTAPPPPPGPPPPSLplGGSVAPGGDVRRRPPSRSPaakpAAPARPPVRRLARPAVSRSTESFAlppdqPERPPQPQA 2913

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641  541 VGGGGGGGERGHPWVLTAPPPTPPRSKSswsgPPRPRARSRAHPPNPGGPPPEEGPRRAPPPRRAARRFAPSPAPVARVP 620
Cdd:PHA03247  2914 PPPPQPQPQPPPPPQPQPPPPPPPRPQP----PLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAP 2989
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 448-637 3.77e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.82  E-value: 3.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641 448 PGKSPSRRRPGPLGSRRSSAIGIESIQEAPPGRDGPAANTDGAGSAHSSPESRRHPDRTAARPrGPPASATPSPTPPGQR 527
Cdd:PRK07764  598 EGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVP-DASDGGDGWPAKAGGA 676

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641 528 SPSAPPQVAQPWGVGGGggggerghpwvlTAPPPTPPRSKSSWSGPPRPRARSRAHPPNPGGPPPEEGPRRAPP------ 601
Cdd:PRK07764  677 APAAPPPAPAPAAPAAP------------AGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPvplppe 744

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2308379641 602 --PRRAARRFAPSPAPVARVPGAEAIVPVLSPQTAEKP 637
Cdd:PRK07764  745 pdDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEE 782
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
447-643 3.89e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.71  E-value: 3.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641 447 VPGKSPSRRRPGPLGSRRSSAIGiesiQEAPPGRDGPAANTDGAGSAHSSPESRRHPDRTAARPRGPPASATPSPTPPGQ 526
Cdd:PRK12323  382 VAQPAPAAAAPAAAAPAPAAPPA----APAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAA 457

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641 527 RSPSAPPQVAQPWGV-GGGGGGGERGHPWVLTAPPP--TPPRSKSSWSGPPRPRARSRAHPPNPGGPPPEEGPRRAPPPR 603
Cdd:PRK12323  458 PAAAARPAAAGPRPVaAAAAAAPARAAPAAAPAPADddPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDA 537

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2308379641 604 RAARRFAPSPAPVARVPGA-EAIVPVLSPQTAEKPLGS----KWP 643
Cdd:PRK12323  538 FETLAPAPAAAPAPRAAAAtEPVVAPRPPRASASGLPDmfdgDWP 582
PHA03247 PHA03247
large tegument protein UL36; Provisional
 474-582 5.58e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 5.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641  474 QEAPPGRDGPAANTDGAGSAHSSPESRRHPD--RTAARPRG-PPASATPSPTPPGQRSPSAPPQVAQPwgvggggGGGER 550
Cdd:PHA03247  2566 RSVPPPRPAPRPSEPAVTSRARRPDAPPQSArpRAPVDDRGdPRGPAPPSPLPPDTHAPDPPPPSPSP-------AANEP 2638

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2308379641  551 GHPWVLTAPPPTPPRSKSSwsgPPRPRARSRA 582
Cdd:PHA03247  2639 DPHPPPTVPPPERPRDDPA---PGRVSRPRRA 2667
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 425-638 1.37e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.90  E-value: 1.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641 425 PGSRRGRRGSAIGLGSVEEALLVPgkSPSRRRPGPLGSRRSSAIGIESIQEAPPGRDGPAANTDGAGSAHSSPESR---R 501
Cdd:PRK07764  592 PGAAGGEGPPAPASSGPPEEAARP--AAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGgdgW 669

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641 502 HPDRTAARPRGPPASATPSPTPPGQRSPSAPPQVAQPWgvgggggggerghpwvltapPPTPPRSKSSWSGPPRPRARSR 581
Cdd:PRK07764  670 PAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAA--------------------TPPAGQADDPAAQPPQAAQGAS 729

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2308379641 582 AHPPNPGGPPPEEGPRRAPPPRRAARRFAPSPAPVARVPGAEAIVPVLSPQTAEKPL 638
Cdd:PRK07764  730 APSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMA 786
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 475-582 1.46e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 41.62  E-value: 1.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641 475 EAPPGRDGPAANTDGAGSAHSSPESRRHPDRTAARPrgpPASATPSPTPPGQRSPSAP----------------PQVAQP 538
Cdd:PRK14951  371 EAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAA---PAAAASAPAAPPAAAPPAPvaapaaaapaaapaaaPAAVAL 447

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2308379641 539 WGVGGGGGGGERGHPWVLTAPPPTPPRSKSSWSGPPRPRARSRA 582
Cdd:PRK14951  448 APAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPT 491
PHA03381 PHA03381
tegument protein VP22; Provisional
 427-538 1.71e-03

tegument protein VP22; Provisional


Pssm-ID: 177618 [Multi-domain]  Cd Length: 290  Bit Score: 40.76  E-value: 1.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641 427 SRRGRRGSAIGLGSVEEALLVPGKSPSRRRPGPLGSRRSSAIGIESIQEAPPGRDGPAANTdGAGSAHSSPESRRHPD-R 505
Cdd:PHA03381   55 SQAERRFHHYDEARADYPYYTGSSSEDERPADPRPSRRPHAQPEASGPGPARGARGPAGSR-GRGRRAESPSPRDPPNpK 133

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2308379641 506 TAARPRGPPASATPSPTPPGQRSPSAPPQVAQP 538
Cdd:PHA03381  134 GASAPRGRKSACADSAALLDAPAPAAPKRQKTP 166
PHA03381 PHA03381
tegument protein VP22; Provisional
 376-539 2.00e-03

tegument protein VP22; Provisional


Pssm-ID: 177618 [Multi-domain]  Cd Length: 290  Bit Score: 40.76  E-value: 2.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641 376 RTRAALLETLHEELQGRSQAMLGLGPDDERPdngsatpgffesfksllvPGSRRGRRGSAiglgsVEEAllvPGKSPSRR 455
Cdd:PHA03381   54 RSQAERRFHHYDEARADYPYYTGSSSEDERP------------------ADPRPSRRPHA-----QPEA---SGPGPARG 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641 456 RPGPLGSRrssaiGIESIQEAPPGRDGPaaNTDGA----GSAHSSPESRRHPDRTAarPRGPPASATPSPTPPGQRSPSA 531
Cdd:PHA03381  108 ARGPAGSR-----GRGRRAESPSPRDPP--NPKGAsaprGRKSACADSAALLDAPA--PAAPKRQKTPAGLARKLHFSTA 178


                  ....*...
gi 2308379641 532 PPQVAQPW 539
Cdd:PHA03381  179 PTSPTAPW 186
PHA03247 PHA03247
large tegument protein UL36; Provisional
 401-583 3.64e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 3.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641  401 PDDERPDNGSATPGFFESFKSL---LVPGSRRGRRGSAiglGSVEEALLVPGKSPSRRRPGPLGSRRSSAIGIESIQEAP 477
Cdd:PHA03247  2831 PTSAQPTAPPPPPGPPPPSLPLggsVAPGGDVRRRPPS---RSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPER 2907

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641  478 PgrdgpaantdgagsahSSPESRRHPDRTAARPrgPPASATPSPTPPGqRSPSAPPQVAQPWGVGGGGGGGERGHPWVLT 557
Cdd:PHA03247  2908 P----------------PQPQAPPPPQPQPQPP--PPPQPQPPPPPPP-RPQPPLAPTTDPAGAGEPSGAVPQPWLGALV 2968

                          170       180
                   ....*....|....*....|....*.
gi 2308379641  558 APPPTPPRSKSSWSGPPRPRARSRAH 583
Cdd:PHA03247  2969 PGRVAVPRFRVPQPAPSREAPASSTP 2994
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 451-574 5.18e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.14  E-value: 5.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641 451 SPSRRRPGPLGSRRSSAIGIESIQEAPPGRDGPAANTDGAGSAHSSPESRRHPDRTAARPRGPPASATPSPTPPGQRSPS 530
Cdd:pfam03154 145 SPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQST 224

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2308379641 531 APPQVAQPWGVGGGGGGGERGHPWVLTAPPPTPPRSKSSWSGPP 574
Cdd:pfam03154 225 AAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQ 268
PHA03247 PHA03247
large tegument protein UL36; Provisional
 452-582 6.82e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 6.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2308379641  452 PSRRRPG--PLGSRRSSAIGiesiqEAPPGRDGPAANTDGAGSAHSSPESRRHPDRTAARPRGPPASATPSPTPPGQRSP 529
Cdd:PHA03247   352 PKRRRPTwtPPSSLEDLSAG-----RHHPKRASLPTRKRRSARHAATPFARGPGGDDQTRPAAPVPASVPTPAPTPVPAS 426

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2308379641  530 sAPPQVAQPWGVGGGGGGGERGHPwvltaPPPTPPRSKSSWSGPPRPRARSRA 582
Cdd:PHA03247   427 -APPPPATPLPSAEPGSDDGPAPP-----PERQPPAPATEPAPDDPDDATRKA 473
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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