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Conserved domains on  [gi|2238760361|ref|XP_048054485|]
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putative cyclin-dependent serine/threonine-protein kinase DDB_G0272797/DDB_G0274007 [Megalobrama amblycephala]

Protein Classification

PDGF domain-containing protein( domain architecture ID 10448475)

PDGF domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PDGF pfam00341
PDGF/VEGF domain;
86-169 1.33e-33

PDGF/VEGF domain;


:

Pssm-ID: 425620  Cd Length: 82  Bit Score: 121.63  E-value: 1.33e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2238760361  86 CKIRTEVIEVTRSMLDRSNANFLlwPPCVEVQRCSGCCNTKTLQCVPVLTHTRYLQVMKIQYVNKRPLYDKAVVSVIDHV 165
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFK--PSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEYAPRRPSPELVEVSFEEHV 78


                  ....
gi 2238760361 166 ECRC 169
Cdd:pfam00341  79 QCEC 82
 
Name Accession Description Interval E-value
PDGF pfam00341
PDGF/VEGF domain;
86-169 1.33e-33

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 121.63  E-value: 1.33e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2238760361  86 CKIRTEVIEVTRSMLDRSNANFLlwPPCVEVQRCSGCCNTKTLQCVPVLTHTRYLQVMKIQYVNKRPLYDKAVVSVIDHV 165
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFK--PSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEYAPRRPSPELVEVSFEEHV 78


                  ....
gi 2238760361 166 ECRC 169
Cdd:pfam00341  79 QCEC 82
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 84-171 2.03e-23

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 94.02  E-value: 2.03e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2238760361   84 AICKIRTEVIEVTRSMLDRSNanFLLWPPCVEVQRCSGCCNTKTLQCVPVLTHTRYLQVMKIqyvnKRPLYDKAV-VSVI 162
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETN--FLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTMQLLEI----SRPLSQHLVeVSFE 74


                   ....*....
gi 2238760361  163 DHVECRCQP 171
Cdd:smart00141  75 EHTKCECRP 83
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 84-171 2.65e-23

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 93.59  E-value: 2.65e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2238760361  84 AICKIRTEVIEVTRSMLDRsnANFLLWPPCVEVQRCSGCCNTKTLQCVPVLTHTRYLQVMKIQYVNKRPLyDKAVVSVID 163
Cdd:cd00135     1 SSCKPRETLVEISEELPDE--TNTIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPKRKPRS-KLVEISFEE 77


                  ....*...
gi 2238760361 164 HVECRCQP 171
Cdd:cd00135    78 HTECECRP 85
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 86-175 1.90e-10

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 58.86  E-value: 1.90e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2238760361  86 CKIRTEVIEVTRSMLDRSNANFLlwPPCVEVQRCSGCCNTKTLQCVPVLTHTRYLQVMKIQYVNKRPLYDKAVV-SVIDH 164
Cdd:PHA02661   48 CQPRDTVVQLSDEYPGNTNDRYN--PRCVTVRRCGGCCNDESQICTPTETSNVTVTVMLTSVSGSTGATSNFQTiSVEEH 125

                          90
                  ....*....|.
gi 2238760361 165 VECRCQPAPRP 175
Cdd:PHA02661  126 TKCKCEFKTTP 136
 
Name Accession Description Interval E-value
PDGF pfam00341
PDGF/VEGF domain;
86-169 1.33e-33

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 121.63  E-value: 1.33e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2238760361  86 CKIRTEVIEVTRSMLDRSNANFLlwPPCVEVQRCSGCCNTKTLQCVPVLTHTRYLQVMKIQYVNKRPLYDKAVVSVIDHV 165
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFK--PSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEYAPRRPSPELVEVSFEEHV 78


                  ....
gi 2238760361 166 ECRC 169
Cdd:pfam00341  79 QCEC 82
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 84-171 2.03e-23

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 94.02  E-value: 2.03e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2238760361   84 AICKIRTEVIEVTRSMLDRSNanFLLWPPCVEVQRCSGCCNTKTLQCVPVLTHTRYLQVMKIqyvnKRPLYDKAV-VSVI 162
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETN--FLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTMQLLEI----SRPLSQHLVeVSFE 74


                   ....*....
gi 2238760361  163 DHVECRCQP 171
Cdd:smart00141  75 EHTKCECRP 83
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 84-171 2.65e-23

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 93.59  E-value: 2.65e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2238760361  84 AICKIRTEVIEVTRSMLDRsnANFLLWPPCVEVQRCSGCCNTKTLQCVPVLTHTRYLQVMKIQYVNKRPLyDKAVVSVID 163
Cdd:cd00135     1 SSCKPRETLVEISEELPDE--TNTIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPKRKPRS-KLVEISFEE 77


                  ....*...
gi 2238760361 164 HVECRCQP 171
Cdd:cd00135    78 HTECECRP 85
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 86-175 1.90e-10

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 58.86  E-value: 1.90e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2238760361  86 CKIRTEVIEVTRSMLDRSNANFLlwPPCVEVQRCSGCCNTKTLQCVPVLTHTRYLQVMKIQYVNKRPLYDKAVV-SVIDH 164
Cdd:PHA02661   48 CQPRDTVVQLSDEYPGNTNDRYN--PRCVTVRRCGGCCNDESQICTPTETSNVTVTVMLTSVSGSTGATSNFQTiSVEEH 125

                          90
                  ....*....|.
gi 2238760361 165 VECRCQPAPRP 175
Cdd:PHA02661  126 TKCKCEFKTTP 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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