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Conserved domains on  [gi|2217328834|ref|XP_047300692|]
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pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X2 [Homo sapiens]

Protein Classification

PDK/BCKDK family protein kinase( domain architecture ID 13768654)

PDK/BCKDK family protein kinase contains a histidine kinase-like ATPase domain and catalyzes the phosphorylation of protein substrates, such as branched-chain alpha-ketoacid dehydrogenase (BCKD) kinase that catalyzes the phosphorylation and inactivation of the BCKD complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways

CATH:  3.30.565.10|1.20.140.20
EC:  2.7.11.-
Gene Ontology:  GO:0004672|GO:0005524|GO:0006468

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 148-314 1.08e-75

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


:

Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 231.08  E-value: 1.08e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834 148 NVLEVIKDGYENARRLCDLYYINSPELELEelnaksPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHANRG-VYPPIQ 226
Cdd:cd16929     1 SPKKVVEDASEEARVLCDDYYLSSPELEIE------GDPSIRFPYVPSHLYYILFELLKNAMRATVESHGDDSdDLPPIK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834 227 VHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRP-------RVETSRAVPLAGFGYGLPISRLYAQYFQGDLKL 299
Cdd:cd16929    75 VTVAKGDEDLTIKISDRGGGIPREDLARLFSYMYSTAPQPslddfsdLISGTQPSPLAGFGYGLPMSRLYAEYFGGDLDL 154

                         170
                  ....*....|....*
gi 2217328834 300 YSLEGYGTDAVIYIK 314
Cdd:cd16929   155 QSMEGYGTDVYIYLK 169
BCDHK_Adom3 pfam10436
Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of ...
 2-144 5.36e-57

Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal.


:

Pssm-ID: 463093  Cd Length: 158  Bit Score: 182.70  E-value: 5.36e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834   2 FLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQELLDFKDKSAEDAKAiydFTDTVIRIRNRHNDVIPTMA 81
Cdd:pfam10436  25 FLREELPVRLAHRIRELQNLPYILVSNPSISKVYEWYLQSFEELLSFPPPILEDNEK---FTELLEEILDRHNDVVPTLA 101

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217328834  82 QGVIEYKESfgvdpVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKgKGSPSHRKHIGSIN 144
Cdd:pfam10436 102 QGVLELKKY-----LSPEEIQSFLDRFLRSRIGIRLLAEQHIALTEQS-NNPSHPPDYVGIID 158
 
Name Accession Description Interval E-value
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 148-314 1.08e-75

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 231.08  E-value: 1.08e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834 148 NVLEVIKDGYENARRLCDLYYINSPELELEelnaksPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHANRG-VYPPIQ 226
Cdd:cd16929     1 SPKKVVEDASEEARVLCDDYYLSSPELEIE------GDPSIRFPYVPSHLYYILFELLKNAMRATVESHGDDSdDLPPIK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834 227 VHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRP-------RVETSRAVPLAGFGYGLPISRLYAQYFQGDLKL 299
Cdd:cd16929    75 VTVAKGDEDLTIKISDRGGGIPREDLARLFSYMYSTAPQPslddfsdLISGTQPSPLAGFGYGLPMSRLYAEYFGGDLDL 154

                         170
                  ....*....|....*
gi 2217328834 300 YSLEGYGTDAVIYIK 314
Cdd:cd16929   155 QSMEGYGTDVYIYLK 169
BCDHK_Adom3 pfam10436
Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of ...
 2-144 5.36e-57

Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal.


Pssm-ID: 463093  Cd Length: 158  Bit Score: 182.70  E-value: 5.36e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834   2 FLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQELLDFKDKSAEDAKAiydFTDTVIRIRNRHNDVIPTMA 81
Cdd:pfam10436  25 FLREELPVRLAHRIRELQNLPYILVSNPSISKVYEWYLQSFEELLSFPPPILEDNEK---FTELLEEILDRHNDVVPTLA 101

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217328834  82 QGVIEYKESfgvdpVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKgKGSPSHRKHIGSIN 144
Cdd:pfam10436 102 QGVLELKKY-----LSPEEIQSFLDRFLRSRIGIRLLAEQHIALTEQS-NNPSHPPDYVGIID 158
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 194-314 2.03e-20

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 85.39  E-value: 2.03e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834  194 PSHLYHMVFELFKNAMRATMEHhanrgvyPPIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVetsra 273
Cdd:smart00387   3 PDRLRQVLSNLLDNAIKYTPEG-------GRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRK----- 70

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 2217328834  274 vpLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIK 314
Cdd:smart00387  71 --IGGTGLGLSIVKKLVELHGGEISVESEPGGGTTFTITLP 109
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 193-314 5.37e-15

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 70.09  E-value: 5.37e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834 193 VPSHLYHMVFELFKNAMRATMEHhanrgvyPPIQVHVTLGNeDLTVKMSDRGGGVPLRKIDRLFNyMYSTAPRPRVEtsr 272
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAAKA-------GEITVTLSEGG-ELTLTVEDNGIGIPPEDLPRIFE-PFSTADKRGGG--- 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2217328834 273 avplaGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIK 314
Cdd:pfam02518  70 -----GTGLGLSIVRKLVELLGGTITVESEPGGGTTVTLTLP 106
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
141-313 1.34e-12

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 66.47  E-value: 1.34e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834 141 GSINPN---CNVLEVIKDGYENARRLCDLYYInspELELEelnakSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHha 217
Cdd:COG2205    82 GKLSLElepVDLAELLEEAVEELRPLAEEKGI---RLELD-----LPPELPLVYADPELLEQVLANLLDNAIKYSPPG-- 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834 218 nrgvyPPIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYstaprpRVETSRAVPlaGFGYGLPISRLYAQYFQGDL 297
Cdd:COG2205   152 -----GTITISARREGDGVRISVSDNGPGIPEEELERIFERFY------RGDNSRGEG--GTGLGLAIVKRIVEAHGGTI 218

                         170
                  ....*....|....*.
gi 2217328834 298 KLYSLEGYGTDAVIYI 313
Cdd:COG2205   219 WVESEPGGGTTFTVTL 234
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 187-315 5.37e-04

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 41.85  E-value: 5.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834 187 PIQVVYVPSHLYHMVFELFKNAMRATMEHHanrgvyppiqVHVTL---GNEDLTVKMSDRGGGVPLRKIDRLFNyMYSTA 263
Cdd:PRK11091  389 PHKVITDGTRLRQILWNLISNAVKFTQQGG----------VTVRVryeEGDMLTFEVEDSGIGIPEDELDKIFA-MYYQV 457

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2217328834 264 PRpRVETSRAVplaGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKA 315
Cdd:PRK11091  458 KD-SHGGKPAT---GTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIHA 505
 
Name Accession Description Interval E-value
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 148-314 1.08e-75

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 231.08  E-value: 1.08e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834 148 NVLEVIKDGYENARRLCDLYYINSPELELEelnaksPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHANRG-VYPPIQ 226
Cdd:cd16929     1 SPKKVVEDASEEARVLCDDYYLSSPELEIE------GDPSIRFPYVPSHLYYILFELLKNAMRATVESHGDDSdDLPPIK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834 227 VHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRP-------RVETSRAVPLAGFGYGLPISRLYAQYFQGDLKL 299
Cdd:cd16929    75 VTVAKGDEDLTIKISDRGGGIPREDLARLFSYMYSTAPQPslddfsdLISGTQPSPLAGFGYGLPMSRLYAEYFGGDLDL 154

                         170
                  ....*....|....*
gi 2217328834 300 YSLEGYGTDAVIYIK 314
Cdd:cd16929   155 QSMEGYGTDVYIYLK 169
BCDHK_Adom3 pfam10436
Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of ...
 2-144 5.36e-57

Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal.


Pssm-ID: 463093  Cd Length: 158  Bit Score: 182.70  E-value: 5.36e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834   2 FLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQELLDFKDKSAEDAKAiydFTDTVIRIRNRHNDVIPTMA 81
Cdd:pfam10436  25 FLREELPVRLAHRIRELQNLPYILVSNPSISKVYEWYLQSFEELLSFPPPILEDNEK---FTELLEEILDRHNDVVPTLA 101

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217328834  82 QGVIEYKESfgvdpVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKgKGSPSHRKHIGSIN 144
Cdd:pfam10436 102 QGVLELKKY-----LSPEEIQSFLDRFLRSRIGIRLLAEQHIALTEQS-NNPSHPPDYVGIID 158
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 194-314 2.03e-20

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 85.39  E-value: 2.03e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834  194 PSHLYHMVFELFKNAMRATMEHhanrgvyPPIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVetsra 273
Cdd:smart00387   3 PDRLRQVLSNLLDNAIKYTPEG-------GRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRK----- 70

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 2217328834  274 vpLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIK 314
Cdd:smart00387  71 --IGGTGLGLSIVKKLVELHGGEISVESEPGGGTTFTITLP 109
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 193-314 5.37e-15

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 70.09  E-value: 5.37e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834 193 VPSHLYHMVFELFKNAMRATMEHhanrgvyPPIQVHVTLGNeDLTVKMSDRGGGVPLRKIDRLFNyMYSTAPRPRVEtsr 272
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAAKA-------GEITVTLSEGG-ELTLTVEDNGIGIPPEDLPRIFE-PFSTADKRGGG--- 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2217328834 273 avplaGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIK 314
Cdd:pfam02518  70 -----GTGLGLSIVRKLVELLGGTITVESEPGGGTTVTLTLP 106
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
141-313 1.34e-12

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 66.47  E-value: 1.34e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834 141 GSINPN---CNVLEVIKDGYENARRLCDLYYInspELELEelnakSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHha 217
Cdd:COG2205    82 GKLSLElepVDLAELLEEAVEELRPLAEEKGI---RLELD-----LPPELPLVYADPELLEQVLANLLDNAIKYSPPG-- 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834 218 nrgvyPPIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYstaprpRVETSRAVPlaGFGYGLPISRLYAQYFQGDL 297
Cdd:COG2205   152 -----GTITISARREGDGVRISVSDNGPGIPEEELERIFERFY------RGDNSRGEG--GTGLGLAIVKRIVEAHGGTI 218

                         170
                  ....*....|....*.
gi 2217328834 298 KLYSLEGYGTDAVIYI 313
Cdd:COG2205   219 WVESEPGGGTTFTVTL 234
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
178-313 2.00e-10

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 61.08  E-value: 2.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834 178 ELNAKSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHanrgvypPIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFN 257
Cdd:COG0642   205 ELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGG-------TVTVSVRREGDRVRISVEDTGPGIPPEDLERIFE 277

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217328834 258 YMYSTAPRPRVEtsravplaGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYI 313
Cdd:COG0642   278 PFFRTDPSRRGG--------GTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTL 325
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
178-307 1.21e-06

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 49.94  E-value: 1.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834 178 ELNAKSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHanrgvypPIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFN 257
Cdd:COG5002   263 ELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGG-------TITVSLREEDDQVRISVRDTGIGIPEEDLPRIFE 335

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2217328834 258 YMYstaprpRVETSRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGT 307
Cdd:COG5002   336 RFY------RVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGT 379
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 200-313 5.25e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 44.59  E-value: 5.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834 200 MVFELFKNAMRATMEHHAnrgvyPPIQVHVTLGNE--DLTVKMSDRGGGVPLRKIDRLFNYMYST-APRPRvetsravpl 276
Cdd:cd16915     4 IVGNLIDNALDALAATGA-----PNKQVEVFLRDEgdDLVIEVRDTGPGIAPELRDKVFERGVSTkGQGER--------- 69

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2217328834 277 agfGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYI 313
Cdd:cd16915    70 ---GIGLALVRQSVERLGGSITVESEPGGGTTFSIRI 103
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 204-313 6.76e-06

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 47.65  E-value: 6.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834 204 LFKNAMRAtMEHHanrgvyPPIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRprvetsravplaGFGYGL 283
Cdd:COG5000   325 LLKNAIEA-IEEG------GEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKPK------------GTGLGL 385

                          90       100       110
                  ....*....|....*....|....*....|
gi 2217328834 284 PISRLYAQYFQGDLKLYSLEGYGTDAVIYI 313
Cdd:COG5000   386 AIVKKIVEEHGGTIELESRPGGGTTFTIRL 415
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 204-313 1.59e-05

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 46.38  E-value: 1.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834 204 LFKNAMRATMEHHANRgvyPPIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTaprpRVETSRavplagfGYGL 283
Cdd:COG3290   289 LLDNAIEAVEKLPEEE---RRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFST----KLGEGR-------GLGL 354

                          90       100       110
                  ....*....|....*....|....*....|
gi 2217328834 284 PISRLYAQYFQGDLKLYSLEGYGTDAVIYI 313
Cdd:COG3290   355 ALVKQIVEKYGGTIEVESEEGEGTVFTVRL 384
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 201-307 6.11e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 41.61  E-value: 6.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834 201 VFELFKNAMRATMEHHANRGvyppiQVHVTLGNED---LTVKMSDRGGGVPLRKIDRLFNYMYSTAPrprvetsravplA 277
Cdd:cd16920     5 LINLVRNGIEAMSEGGCERR-----ELTIRTSPADdraVTISVKDTGPGIAEEVAGQLFDPFYTTKS------------E 67

                          90       100       110
                  ....*....|....*....|....*....|
gi 2217328834 278 GFGYGLPISRLYAQYFQGDLKLYSLEGYGT 307
Cdd:cd16920    68 GLGMGLSICRSIIEAHGGRLSVESPAGGGA 97
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 225-299 6.98e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 41.68  E-value: 6.98e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217328834 225 IQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTaPRPRVETSRAvplagfGYGLPISRLYAQYFQGDLKL 299
Cdd:cd16945    26 IALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSL-PRPHSGQKST------GLGLAFVQEVAQLHGGRITL 93
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 204-301 8.17e-05

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 44.29  E-value: 8.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834 204 LFKNAMRATMEHhanrgvyPPIQVHVTLGNEDLTVKMSDRGGGVPLrkIDRLFNYMYSTAPrprvetsravplAGFGYGL 283
Cdd:COG4192   551 LLVNALDAVATQ-------PQISVDLLSNAENLRVAISDNGNGWPL--VDKLFTPFTTTKE------------VGLGLGL 609

                          90
                  ....*....|....*...
gi 2217328834 284 PISRLYAQYFQGDLKLYS 301
Cdd:COG4192   610 SICRSIMQQFGGDLYLAS 627
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 194-297 1.35e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 40.91  E-value: 1.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834 194 PSHLYHMVFELFKNAMRATmeHHANRgvyppIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYstaprpRVETSRA 273
Cdd:cd16946     2 RDRLQQLFVNLLENSLRYT--DTGGK-----LRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFY------RVESSRN 68

                          90       100
                  ....*....|....*....|....
gi 2217328834 274 VPLAGFGYGLPISRLYAQYFQGDL 297
Cdd:cd16946    69 RASGGSGLGLAICHNIALAHGGTI 92
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 194-313 1.49e-04

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 43.25  E-value: 1.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834 194 PSHLYHMVFELFKNAMRATMEHHANRgvyppIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRvetsra 273
Cdd:COG4191   254 PGQLEQVLLNLLINAIDAMEEGEGGR-----ITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTTKPVGK------ 322

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2217328834 274 vplaGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYI 313
Cdd:COG4191   323 ----GTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITL 358
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 187-311 4.06e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 39.70  E-value: 4.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834 187 PIQVVYVPSHLYHMVFELFKNAMRatmehhanrgvYPP--IQVHVTLGNEDLTV-KMSDRGGGVPLRKIDRLFNYMYSTA 263
Cdd:cd16940     4 DIQVQGDALLLFLLLRNLVDNAVR-----------YSPqgSRVEIKLSADDGAViRVEDNGPGIDEEELEALFERFYRSD 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2217328834 264 PRprvetsravPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVI 311
Cdd:cd16940    73 GQ---------NYGGSGLGLSIVKRIVELHGGQIFLGNAQGGGLEAWV 111
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 187-315 5.37e-04

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 41.85  E-value: 5.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834 187 PIQVVYVPSHLYHMVFELFKNAMRATMEHHanrgvyppiqVHVTL---GNEDLTVKMSDRGGGVPLRKIDRLFNyMYSTA 263
Cdd:PRK11091  389 PHKVITDGTRLRQILWNLISNAVKFTQQGG----------VTVRVryeEGDMLTFEVEDSGIGIPEDELDKIFA-MYYQV 457

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2217328834 264 PRpRVETSRAVplaGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKA 315
Cdd:PRK11091  458 KD-SHGGKPAT---GTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIHA 505
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 201-306 8.83e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 38.21  E-value: 8.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834 201 VFELFKNAMRAtMEHHANrgvyPPIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRvetsravplaGFG 280
Cdd:cd16976     5 LMNLLQNALDA-MGKVEN----PRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGK----------GTG 69

                          90       100
                  ....*....|....*....|....*.
gi 2217328834 281 YGLPISRLYAQYFQGDLKLYSLEGYG 306
Cdd:cd16976    70 LGLSISYGIVEEHGGRLSVANEEGAG 95
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 223-287 9.53e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 38.32  E-value: 9.53e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217328834 223 PPIQVHVTL----GNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAvplagfGYGLPISR 287
Cdd:cd16953    17 PPDTGRITVsampTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHS------GLGLSISR 79
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 204-299 1.13e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 38.18  E-value: 1.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834 204 LFKNAMRatmehHANRGVyppiQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNymystaPRPRVETSRAVPLAGFGYGL 283
Cdd:cd16939     8 LLRNALR-----YAHRTV----RIALLVSGGRLTLIVEDDGPGIPAAARERVFE------PFVRLDPSRDRATGGFGLGL 72

                          90
                  ....*....|....*.
gi 2217328834 284 PISRLYAQYFQGDLKL 299
Cdd:cd16939    73 AIVHRVALWHGGHVEC 88
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 225-311 1.40e-03

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 40.60  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834 225 IQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTaPRPrvETSRavplAGFGYGLPISRLYAQYFQGDLKLYSLEG 304
Cdd:PRK11100  390 ITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYSL-PRP--ANGR----KSTGLGLAFVREVARLHGGEVTLRNRPE 462


                  ....*..
gi 2217328834 305 YGTDAVI 311
Cdd:PRK11100  463 GGVLATL 469
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
204-320 1.47e-03

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 40.34  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834 204 LFKNAMRATmehhANRGVyppIQVHVTL-GNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRprvetsravplaGFGYG 282
Cdd:PRK11360  508 ILINAVQAI----SARGK---IRIRTWQySDGQVAVSIEDNGCGIDPELLKKIFDPFFTTKAK------------GTGLG 568

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2217328834 283 LPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTDS 320
Cdd:PRK11360  569 LALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQGN 606
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 236-313 1.83e-03

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 37.74  E-value: 1.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834 236 LTVKMSDRGGGVPLRKIDRLFNYMYSTAPrprvetsravplAGFGYGLPISRLYAQYFQ--GDLKLYSLEGYGTDAVIYI 313
Cdd:cd16919    48 VCLEVSDTGSGMPAEVLRRAFEPFFTTKE------------VGKGTGLGLSMVYGFVKQsgGHLRIYSEPGVGTTVRIYL 115
PRK15347 PRK15347
two component system sensor kinase;
225-307 3.61e-03

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 39.24  E-value: 3.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834 225 IQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYstaprpRVETSRAvplaGFGYGLPISRLYAQYFQGDLKLYSLEG 304
Cdd:PRK15347  534 IRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFY------QADTHSQ----GTGLGLTIASSLAKMMGGELTLFSTPG 603


                  ...
gi 2217328834 305 YGT 307
Cdd:PRK15347  604 VGS 606
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 225-313 5.07e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 36.27  E-value: 5.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834 225 IQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNymystaPRPRVETSRAVplAGFGYGLPISRLYAQYFQGDLKLYSLEG 304
Cdd:cd16950    20 VEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQ------PFYRGDNARGT--SGTGLGLAIVQRISDAHGGSLTLANRAG 91


                  ....*....
gi 2217328834 305 YGTDAVIYI 313
Cdd:cd16950    92 GGLCARIEL 100
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
203-290 5.27e-03

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 36.43  E-value: 5.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328834 203 ELFKNAMRatmehHANRGVYP-PIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNymystaprprvetsravPLAGFGY 281
Cdd:COG2172    41 EAVTNAVR-----HAYGGDPDgPVEVELELDPDGLEIEVRDEGPGFDPEDLPDPYS-----------------TLAEGGR 98


                  ....*....
gi 2217328834 282 GLPISRLYA 290
Cdd:COG2172    99 GLFLIRRLM 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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