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Conserved domains on  [gi|2217326743|ref|XP_047299820|]
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V-type proton ATPase subunit C 2 isoform X8 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
V-ATPase_C super family cl15414
Subunit C of vacuolar H+-ATPase (V-ATPase); This family contains subunit C of vacuolar H ...
 1-70 3.05e-27

Subunit C of vacuolar H+-ATPase (V-ATPase); This family contains subunit C of vacuolar H+-ATPase (V-ATPase), a protein that plays a crucial role in the vacuolar system of eukaryotic cells. The main function of V-ATPase is to generate a proton-motive force at the expense of ATP and to cause limited acidification in the internal space (lumen) of several organelles of the vacuolar system. V-ATPases are multi-subunit protein complexes made up of two distinct structures: a peripheral catalytic sector (V1) and a hydrophobic membrane sector (V0) responsible for driving protons; subunit C is one of five polypeptides composing V1. The key function of the C subunit is intimately involved in the reversible dissociation of the V1 and V0 structures. It has also been identified as a mediator of the acidic microenvironment of tumors which it controls by proton extrusion to the extracellular medium. The acidic environment causes tissue damage, activates destructive enzymes in the extracellular matrix, and acquires metastatic cell phenotypes.


The actual alignment was detected with superfamily member pfam03223:

Pssm-ID: 472803  Cd Length: 367  Bit Score: 107.99  E-value: 3.05e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217326743   1 MVVPRSTKLITEDKEGGLFTVTLFRKVIEDFKTKAKENKFTVREFYYDEKEIEREREEMARLLSDKKQQY 70
Cdd:pfam03223 202 MVVPRSAKKIAEDDEYTLFTVTLFKKVVDEFKHKAREKKFTVRDFKYDEEELEEEKKELDKLAADEKKLW 271
 
Name Accession Description Interval E-value
V-ATPase_C pfam03223
V-ATPase subunit C;
1-70 3.05e-27

V-ATPase subunit C;


Pssm-ID: 460851  Cd Length: 367  Bit Score: 107.99  E-value: 3.05e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217326743   1 MVVPRSTKLITEDKEGGLFTVTLFRKVIEDFKTKAKENKFTVREFYYDEKEIEREREEMARLLSDKKQQY 70
Cdd:pfam03223 202 MVVPRSAKKIAEDDEYTLFTVTLFKKVVDEFKHKAREKKFTVRDFKYDEEELEEEKKELDKLAADEKKLW 271
V-ATPase_C cd14785
Subunit C of vacuolar H+-ATPase (V-ATPase); This family contains subunit C of vacuolar H ...
 1-72 4.28e-24

Subunit C of vacuolar H+-ATPase (V-ATPase); This family contains subunit C of vacuolar H+-ATPase (V-ATPase), a protein that plays a crucial role in the vacuolar system of eukaryotic cells. The main function of V-ATPase is to generate a proton-motive force at the expense of ATP and to cause limited acidification in the internal space (lumen) of several organelles of the vacuolar system. V-ATPases are multi-subunit protein complexes made up of two distinct structures: a peripheral catalytic sector (V1) and a hydrophobic membrane sector (V0) responsible for driving protons; subunit C is one of five polypeptides composing V1. The key function of the C subunit is intimately involved in the reversible dissociation of the V1 and V0 structures. It has also been identified as a mediator of the acidic microenvironment of tumors which it controls by proton extrusion to the extracellular medium. The acidic environment causes tissue damage, activates destructive enzymes in the extracellular matrix, and acquires metastatic cell phenotypes.


Pssm-ID: 270211  Cd Length: 368  Bit Score: 99.61  E-value: 4.28e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217326743   1 MVVPRSTKLITEDKEGGLFTVTLFRKVIEDFKTKAKENKFTVREFYYDEKEIEREREEMARLLSDKKQQYQT 72
Cdd:cd14785   202 MVVPRSSKKIAEDEEYALYSVTLFKKVVDEFKNAAREKKFIVRDFKYDEEAYEEEKEELEKLEAEEKEQETE 273
COG5127 COG5127
Vacuolar H+-ATPase V1 sector, subunit C [Energy production and conversion];
2-48 3.54e-09

Vacuolar H+-ATPase V1 sector, subunit C [Energy production and conversion];


Pssm-ID: 227456  Cd Length: 383  Bit Score: 56.48  E-value: 3.54e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2217326743   2 VVPRSTKLITEDKEGGLFTVTLFRKVIEDFKTKAKENKFTVREFYYD 48
Cdd:COG5127   207 VSPDSAEKVNSDEEYVLFKVYVFKKGEEDFRTMAREEKFMVREFDKN 253
 
Name Accession Description Interval E-value
V-ATPase_C pfam03223
V-ATPase subunit C;
1-70 3.05e-27

V-ATPase subunit C;


Pssm-ID: 460851  Cd Length: 367  Bit Score: 107.99  E-value: 3.05e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217326743   1 MVVPRSTKLITEDKEGGLFTVTLFRKVIEDFKTKAKENKFTVREFYYDEKEIEREREEMARLLSDKKQQY 70
Cdd:pfam03223 202 MVVPRSAKKIAEDDEYTLFTVTLFKKVVDEFKHKAREKKFTVRDFKYDEEELEEEKKELDKLAADEKKLW 271
V-ATPase_C cd14785
Subunit C of vacuolar H+-ATPase (V-ATPase); This family contains subunit C of vacuolar H ...
 1-72 4.28e-24

Subunit C of vacuolar H+-ATPase (V-ATPase); This family contains subunit C of vacuolar H+-ATPase (V-ATPase), a protein that plays a crucial role in the vacuolar system of eukaryotic cells. The main function of V-ATPase is to generate a proton-motive force at the expense of ATP and to cause limited acidification in the internal space (lumen) of several organelles of the vacuolar system. V-ATPases are multi-subunit protein complexes made up of two distinct structures: a peripheral catalytic sector (V1) and a hydrophobic membrane sector (V0) responsible for driving protons; subunit C is one of five polypeptides composing V1. The key function of the C subunit is intimately involved in the reversible dissociation of the V1 and V0 structures. It has also been identified as a mediator of the acidic microenvironment of tumors which it controls by proton extrusion to the extracellular medium. The acidic environment causes tissue damage, activates destructive enzymes in the extracellular matrix, and acquires metastatic cell phenotypes.


Pssm-ID: 270211  Cd Length: 368  Bit Score: 99.61  E-value: 4.28e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217326743   1 MVVPRSTKLITEDKEGGLFTVTLFRKVIEDFKTKAKENKFTVREFYYDEKEIEREREEMARLLSDKKQQYQT 72
Cdd:cd14785   202 MVVPRSSKKIAEDEEYALYSVTLFKKVVDEFKNAAREKKFIVRDFKYDEEAYEEEKEELEKLEAEEKEQETE 273
COG5127 COG5127
Vacuolar H+-ATPase V1 sector, subunit C [Energy production and conversion];
2-48 3.54e-09

Vacuolar H+-ATPase V1 sector, subunit C [Energy production and conversion];


Pssm-ID: 227456  Cd Length: 383  Bit Score: 56.48  E-value: 3.54e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2217326743   2 VVPRSTKLITEDKEGGLFTVTLFRKVIEDFKTKAKENKFTVREFYYD 48
Cdd:COG5127   207 VSPDSAEKVNSDEEYVLFKVYVFKKGEEDFRTMAREEKFMVREFDKN 253
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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