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Conserved domains on  [gi|2217335378|ref|XP_047296180|]
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cardiolipin synthase (CMP-forming) isoform X1 [Homo sapiens]

Protein Classification

CDP-alcohol phosphatidyltransferase family protein( domain architecture ID 10001704)

CDP-alcohol phosphatidyltransferase family protein catalyzes the transfer of a substituted phosphate group from a cytidine-5'-diphosphate-linked donor to an alcohol acceptor, an essential reaction in the biosynthesis of phospholipids

CATH:  1.20.120.1760
EC:  2.7.8.-
Gene Ontology:  GO:0016780|GO:0008654|GO:0016020|GO:0000287
PubMed:  24923293|24573438|21259003|24942835
SCOP:  3002413

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PgsA COG0558
Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; ...
 100-192 3.21e-22

Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; Phosphatidylglycerophosphate synthase is part of the Pathway/BioSystem: Phospholipid biosynthesis


:

Pssm-ID: 440324 [Multi-domain]  Cd Length: 177  Bit Score: 88.76  E-value: 3.21e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217335378 100 PSLYENPWTIPNMLSMTRIGLAPVLGYLIIEEDFN-IALGVFALAGLTDLLDGFIARNWaNQRSALGSALDPLADKILIS 178
Cdd:COG0558     2 PAFQRRLLNIPNQLTLLRILLVPVFALLLLLGGALlLALVLFLLAGLTDALDGYLARRL-GQVSRFGAFLDPVADKLLDA 80

                          90
                  ....*....|....
gi 2217335378 179 ILYVSLTYADLIPA 192
Cdd:COG0558    81 AALLGLVLLGLLPA 94
 
Name Accession Description Interval E-value
PgsA COG0558
Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; ...
 100-192 3.21e-22

Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; Phosphatidylglycerophosphate synthase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440324 [Multi-domain]  Cd Length: 177  Bit Score: 88.76  E-value: 3.21e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217335378 100 PSLYENPWTIPNMLSMTRIGLAPVLGYLIIEEDFN-IALGVFALAGLTDLLDGFIARNWaNQRSALGSALDPLADKILIS 178
Cdd:COG0558     2 PAFQRRLLNIPNQLTLLRILLVPVFALLLLLGGALlLALVLFLLAGLTDALDGYLARRL-GQVSRFGAFLDPVADKLLDA 80

                          90
                  ....*....|....
gi 2217335378 179 ILYVSLTYADLIPA 192
Cdd:COG0558    81 AALLGLVLLGLLPA 94
CDP-OH_P_transf pfam01066
CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the ...
 107-198 3.73e-21

CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.


Pssm-ID: 460049 [Multi-domain]  Cd Length: 157  Bit Score: 85.30  E-value: 3.73e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217335378 107 WTIPNMLSMTRIGLAPVLGYLIIE-EDFNIALGVFALAGLTDLLDGFIARnWANQRSALGSALDPLADKILISILYVSLT 185
Cdd:pfam01066   1 LNLPNLLTLLRILLVPVFVVLLLGpGNRILAAVVFALAALTDFLDGKIAR-KLNQVTDFGKFLDPLADKLLVAAALIALS 79

                          90
                  ....*....|...
gi 2217335378 186 YADLIPATQLCCC 198
Cdd:pfam01066  80 ILGLLPWWFVVVI 92
PLN02794 PLN02794
cardiolipin synthase
 101-190 1.91e-15

cardiolipin synthase


Pssm-ID: 178391  Cd Length: 341  Bit Score: 73.34  E-value: 1.91e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217335378 101 SLYENPWTIPNMLSMTRIGLAPVLGYLIIEEDFNIALGVFALAGLTDLLDGFIARNwANQRSALGSALDPLADKILISIL 180
Cdd:PLN02794  136 GIVKSFVNLPNLISISRLVSGPVIGWMIVNEMYLSAFVGLAISGASDWLDGYVARK-MGINSVVGSYLDPLADKVLIGCV 214

                          90
                  ....*....|
gi 2217335378 181 YVSLTYADLI 190
Cdd:PLN02794  215 ALAMVEKDLL 224
pgsA TIGR00560
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: ...
 109-192 2.49e-14

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: phosphatidylglycerophosphate synthase; glycerophosphate phosphatidyltransferase; PGP synthase. A number of related enzymes are quite similar in both sequence and catalytic activity, including Saccharamyces cerevisiae YDL142c, now known to be a cardiolipin synthase. There may be problems with incorrect transitive annotation of near homologs as authentic CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 273139 [Multi-domain]  Cd Length: 182  Bit Score: 68.15  E-value: 2.49e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217335378 109 IPNMLSMTRIGLAPVLGYLIIEEDFNIAL------GVFALAGLTDLLDGFIARNWaNQRSALGSALDPLADKILISILYV 182
Cdd:TIGR00560   3 IPNWLTLFRIIALPIFILFFLENVLPIQVspfigaLLFIFAAVTDWLDGYLARKW-NQVSNFGKFLDPLADKVLVLAVLI 81

                          90
                  ....*....|
gi 2217335378 183 SLTYADLIPA 192
Cdd:TIGR00560  82 ILVYHGYVPA 91
 
Name Accession Description Interval E-value
PgsA COG0558
Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; ...
 100-192 3.21e-22

Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; Phosphatidylglycerophosphate synthase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440324 [Multi-domain]  Cd Length: 177  Bit Score: 88.76  E-value: 3.21e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217335378 100 PSLYENPWTIPNMLSMTRIGLAPVLGYLIIEEDFN-IALGVFALAGLTDLLDGFIARNWaNQRSALGSALDPLADKILIS 178
Cdd:COG0558     2 PAFQRRLLNIPNQLTLLRILLVPVFALLLLLGGALlLALVLFLLAGLTDALDGYLARRL-GQVSRFGAFLDPVADKLLDA 80

                          90
                  ....*....|....
gi 2217335378 179 ILYVSLTYADLIPA 192
Cdd:COG0558    81 AALLGLVLLGLLPA 94
CDP-OH_P_transf pfam01066
CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the ...
 107-198 3.73e-21

CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.


Pssm-ID: 460049 [Multi-domain]  Cd Length: 157  Bit Score: 85.30  E-value: 3.73e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217335378 107 WTIPNMLSMTRIGLAPVLGYLIIE-EDFNIALGVFALAGLTDLLDGFIARnWANQRSALGSALDPLADKILISILYVSLT 185
Cdd:pfam01066   1 LNLPNLLTLLRILLVPVFVVLLLGpGNRILAAVVFALAALTDFLDGKIAR-KLNQVTDFGKFLDPLADKLLVAAALIALS 79

                          90
                  ....*....|...
gi 2217335378 186 YADLIPATQLCCC 198
Cdd:pfam01066  80 ILGLLPWWFVVVI 92
PLN02794 PLN02794
cardiolipin synthase
 101-190 1.91e-15

cardiolipin synthase


Pssm-ID: 178391  Cd Length: 341  Bit Score: 73.34  E-value: 1.91e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217335378 101 SLYENPWTIPNMLSMTRIGLAPVLGYLIIEEDFNIALGVFALAGLTDLLDGFIARNwANQRSALGSALDPLADKILISIL 180
Cdd:PLN02794  136 GIVKSFVNLPNLISISRLVSGPVIGWMIVNEMYLSAFVGLAISGASDWLDGYVARK-MGINSVVGSYLDPLADKVLIGCV 214

                          90
                  ....*....|
gi 2217335378 181 YVSLTYADLI 190
Cdd:PLN02794  215 ALAMVEKDLL 224
pgsA TIGR00560
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: ...
 109-192 2.49e-14

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: phosphatidylglycerophosphate synthase; glycerophosphate phosphatidyltransferase; PGP synthase. A number of related enzymes are quite similar in both sequence and catalytic activity, including Saccharamyces cerevisiae YDL142c, now known to be a cardiolipin synthase. There may be problems with incorrect transitive annotation of near homologs as authentic CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 273139 [Multi-domain]  Cd Length: 182  Bit Score: 68.15  E-value: 2.49e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217335378 109 IPNMLSMTRIGLAPVLGYLIIEEDFNIAL------GVFALAGLTDLLDGFIARNWaNQRSALGSALDPLADKILISILYV 182
Cdd:TIGR00560   3 IPNWLTLFRIIALPIFILFFLENVLPIQVspfigaLLFIFAAVTDWLDGYLARKW-NQVSNFGKFLDPLADKVLVLAVLI 81

                          90
                  ....*....|
gi 2217335378 183 SLTYADLIPA 192
Cdd:TIGR00560  82 ILVYHGYVPA 91
PRK10832 PRK10832
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;
109-182 7.32e-08

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;


Pssm-ID: 182763 [Multi-domain]  Cd Length: 182  Bit Score: 50.23  E-value: 7.32e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217335378 109 IPNMLSMTRIGLAP--VLG-YLIIEEDFNIALGVFALAGLTDLLDGFIARNWaNQRSALGSALDPLADKILISILYV 182
Cdd:PRK10832    5 IPTLLTLFRVILIPffVLVfYLPFTWAPFVCALIFCVAAVTDWFDGFLARRW-NQSTRFGAFLDPVADKVMVAIAMV 80
PLN02558 PLN02558
CDP-diacylglycerol-glycerol-3-phosphate/ 3-phosphatidyltransferase
 108-178 9.05e-05

CDP-diacylglycerol-glycerol-3-phosphate/ 3-phosphatidyltransferase


Pssm-ID: 166199  Cd Length: 203  Bit Score: 41.94  E-value: 9.05e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217335378 108 TIPNMLSMTRIGLAPVLGYLIIEEDF---NIALGVFALAGLTDLLDGFIARNwANQRSALGSALDPLADKILIS 178
Cdd:PLN02558   10 TLPTVLTLGRVAAVPLLVATFYVDSWwgrTATTSIFIAAAITDWLDGYLARK-MKLGTAFGAFLDPVADKLMVA 82
PssA COG1183
Phosphatidylserine synthase [Lipid transport and metabolism];
109-173 1.39e-03

Phosphatidylserine synthase [Lipid transport and metabolism];


Pssm-ID: 440796 [Multi-domain]  Cd Length: 237  Bit Score: 38.26  E-value: 1.39e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217335378 109 IPNMLSMtrigLAPVLGYLII----EEDFNIALGVFALAGLTDLLDGFIARnWANQRSALGSALDPLAD 173
Cdd:COG1183    12 LPNLFTL----LNLFCGFLAIvaaiEGDFELAALLILLAAVFDGLDGRVAR-LLNVQSEFGAELDSLAD 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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