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Conserved domains on  [gi|2217315144|ref|XP_047293152|]
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leucine-rich repeat-containing protein 37A isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRRC37AB_C super family cl20801
LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of ...
 1468-1578 3.70e-54

LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of the putative Leucine Rich Repeat Containing protein 37A or protein 37B (LRRC37A/B) found in eukaryotes. The Leucine Rich Repeats (LRR) lies in the central region. The gene that encodes this protein is found in the chromosomal position 17q11.2, and its microdeletion results in the disease, neurofibromatosis type-1 (NF1). The function of the protein, LRRC37B is unknown, however experimental data shows expression in the aorta, heart, skeletal muscle, liver and brain during gestation.


The actual alignment was detected with superfamily member pfam14914:

Pssm-ID: 464370  Cd Length: 147  Bit Score: 185.70  E-value: 3.70e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144 1468 SPGDQFEIQLTQQLQSLIPNNNVRRLIAHVIRTLKMDCSGAHVQVTCAKLISRTGHLMKLLSGQQEVKASKIEWDTDQWK 1547
Cdd:pfam14914    1 SPGDQFEIQLNQQLLSLIPNVDVRRLISHVIRTLKMDCSEPQMQLACAKLISRTGLLMKLLSEQQEAKVSKADWDTDQWK 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217315144 1548 IENYINESTEAQSEQKEKS------------------------------------LEICCHRRSLQE 1578
Cdd:pfam14914   81 NENYINESTEAQSKQKKQSsreltkevpgygynnklilaisvtvvimiliiilclIEICSHRSASGE 147
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 560-629 1.57e-22

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


:

Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 92.81  E-value: 1.57e-22
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217315144  560 EVELSPTMKETPTQP---PKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEPTTEVGHST 629
Cdd:pfam15779    1 EVEPSPTQQETPTQPpesPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
PRK10263 super family cl35903
DNA translocase FtsK; Provisional
 206-704 5.04e-15

DNA translocase FtsK; Provisional


The actual alignment was detected with superfamily member PRK10263:

Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 81.28  E-value: 5.04e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  206 PPGPSEQVGPSQFHLE----PETQNPETLEDIQSSSLQQEAPAQLPQLLEEEPssMQQEAPALPPESSMESLTLPNHEVS 281
Cdd:PRK10263   344 PPVASVDVPPAQPTVAwqpvPGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEP--LQQPVQPQQPYYAPAAEQPAQQPYY 421

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  282 VQPPGEDQAYYHLPNITVKPA--------DVEVTITSEPTNETESSQAQ---QETPIQFPEEVEPSATQQEAP----IEP 346
Cdd:PRK10263   422 APAPEQPAQQPYYAPAPEQPVagnawqaeEQQSTFAPQSTYQTEQTYQQpaaQEPLYQQPQPVEQQPVVEPEPvveeTKP 501

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  347 PVPPMEHELSISEQQ-----------QPV-QPSESPREVESSPTQQETPGQPPEHHEVTVSP--PGHHQTHHLASPSVSV 412
Cdd:PRK10263   502 ARPPLYYFEEVEEKRarereqlaawyQPIpEPVKEPEPIKSSLKAPSVAAVPPVEAAAAVSPlaSGVKKATLATGAAATV 581

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  413 KPPDVQLTIAAEPSAEVGTSLVHQ-------EATTRLSGSGNDVEPPAIQhggppLLPESSEEAGPLAVQQETSFQSPEP 485
Cdd:PRK10263   582 AAPVFSLANSGGPRPQVKEGIGPQlprpkriRVPTRRELASYGIKLPSQR-----AAEEKAREAQRNQYDSGDQYNDDEI 656

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  486 INNENPSPTQQEAAAEHPQTAEEGESSLTHQ----EAPAQTPEFPNVVVAQPPEHSHLTQATVQPLDLG-FTITP----- 555
Cdd:PRK10263   657 DAMQQDELARQFAQTQQQRYGEQYQHDVPVNaedaDAAAEAELARQFAQTQQQRYSGEQPAGANPFSLDdFEFSPmkall 736

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  556 -ESKTEVELSPT-MKETPTQPPKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEpTTEVGHSTPPKR 633
Cdd:PRK10263   737 dDGPHEPLFTPIvEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQ-YQQPQQPVAPQP 815

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217315144  634 TIVSPKHPEVTLPHPDQVQTQhshltrATVQPLDLgfTITPKSMTEVEPSTALMTTAPPPGHPEVTLPPSD 704
Cdd:PRK10263   816 QYQQPQQPVAPQPQYQQPQQP------VAPQPQDT--LLHPLLMRNGDSRPLHKPTTPLPSLDLLTPPPSE 878
LRR_8 pfam13855
Leucine rich repeat;
892-949 5.72e-15

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 70.63  E-value: 5.72e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2217315144  892 EKLILRENNLTELHKDSFEGLLSLQYLDLSCNKIQSIERHTFEPLPFLKFINLSCNVI 949
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
868-1020 2.04e-14

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.28  E-value: 2.04e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  868 TILNFQGNYISYIDGNVwkaYSWT--EKLILRENNLTELHkDSFEGLLSLQYLDLSCNKIQSIERHtFEPLPFLKFINLS 945
Cdd:COG4886    116 ESLDLSGNQLTDLPEEL---ANLTnlKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLS 190

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217315144  946 CNVITELSfgtfQAWHGMQFLHKLILNHNPLTTVEDPyLFKLPALKYLDMGTTlvPLTTLKNILMMTvELEKLIL 1020
Cdd:COG4886    191 NNQITDLP----EPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN--QLTDLPELGNLT-NLEELDL 257
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 689-739 5.24e-12

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


:

Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 62.77  E-value: 5.24e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2217315144  689 TAPPPGHPEVTLPPSDKGQAQHSHLTQATVQPLDLELTITTKPTTEVKPSP 739
Cdd:pfam15779   23 VAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 super family cl24370
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 734-799 6.22e-03

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


The actual alignment was detected with superfamily member pfam15779:

Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 36.96  E-value: 6.22e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217315144  734 EVKPSPTTEETSTQPPDLglaiipePTTETGHSTALEKTTAPRPDRVQTLHRSLTEVTGPPTELEP 799
Cdd:pfam15779    1 EVEPSPTQQETPTQPPES-------PKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLEL 59
 
Name Accession Description Interval E-value
LRRC37AB_C pfam14914
LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of ...
 1468-1578 3.70e-54

LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of the putative Leucine Rich Repeat Containing protein 37A or protein 37B (LRRC37A/B) found in eukaryotes. The Leucine Rich Repeats (LRR) lies in the central region. The gene that encodes this protein is found in the chromosomal position 17q11.2, and its microdeletion results in the disease, neurofibromatosis type-1 (NF1). The function of the protein, LRRC37B is unknown, however experimental data shows expression in the aorta, heart, skeletal muscle, liver and brain during gestation.


Pssm-ID: 464370  Cd Length: 147  Bit Score: 185.70  E-value: 3.70e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144 1468 SPGDQFEIQLTQQLQSLIPNNNVRRLIAHVIRTLKMDCSGAHVQVTCAKLISRTGHLMKLLSGQQEVKASKIEWDTDQWK 1547
Cdd:pfam14914    1 SPGDQFEIQLNQQLLSLIPNVDVRRLISHVIRTLKMDCSEPQMQLACAKLISRTGLLMKLLSEQQEAKVSKADWDTDQWK 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217315144 1548 IENYINESTEAQSEQKEKS------------------------------------LEICCHRRSLQE 1578
Cdd:pfam14914   81 NENYINESTEAQSKQKKQSsreltkevpgygynnklilaisvtvvimiliiilclIEICSHRSASGE 147
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 560-629 1.57e-22

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 92.81  E-value: 1.57e-22
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217315144  560 EVELSPTMKETPTQP---PKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEPTTEVGHST 629
Cdd:pfam15779    1 EVEPSPTQQETPTQPpesPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 206-704 5.04e-15

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 81.28  E-value: 5.04e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  206 PPGPSEQVGPSQFHLE----PETQNPETLEDIQSSSLQQEAPAQLPQLLEEEPssMQQEAPALPPESSMESLTLPNHEVS 281
Cdd:PRK10263   344 PPVASVDVPPAQPTVAwqpvPGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEP--LQQPVQPQQPYYAPAAEQPAQQPYY 421

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  282 VQPPGEDQAYYHLPNITVKPA--------DVEVTITSEPTNETESSQAQ---QETPIQFPEEVEPSATQQEAP----IEP 346
Cdd:PRK10263   422 APAPEQPAQQPYYAPAPEQPVagnawqaeEQQSTFAPQSTYQTEQTYQQpaaQEPLYQQPQPVEQQPVVEPEPvveeTKP 501

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  347 PVPPMEHELSISEQQ-----------QPV-QPSESPREVESSPTQQETPGQPPEHHEVTVSP--PGHHQTHHLASPSVSV 412
Cdd:PRK10263   502 ARPPLYYFEEVEEKRarereqlaawyQPIpEPVKEPEPIKSSLKAPSVAAVPPVEAAAAVSPlaSGVKKATLATGAAATV 581

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  413 KPPDVQLTIAAEPSAEVGTSLVHQ-------EATTRLSGSGNDVEPPAIQhggppLLPESSEEAGPLAVQQETSFQSPEP 485
Cdd:PRK10263   582 AAPVFSLANSGGPRPQVKEGIGPQlprpkriRVPTRRELASYGIKLPSQR-----AAEEKAREAQRNQYDSGDQYNDDEI 656

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  486 INNENPSPTQQEAAAEHPQTAEEGESSLTHQ----EAPAQTPEFPNVVVAQPPEHSHLTQATVQPLDLG-FTITP----- 555
Cdd:PRK10263   657 DAMQQDELARQFAQTQQQRYGEQYQHDVPVNaedaDAAAEAELARQFAQTQQQRYSGEQPAGANPFSLDdFEFSPmkall 736

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  556 -ESKTEVELSPT-MKETPTQPPKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEpTTEVGHSTPPKR 633
Cdd:PRK10263   737 dDGPHEPLFTPIvEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQ-YQQPQQPVAPQP 815

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217315144  634 TIVSPKHPEVTLPHPDQVQTQhshltrATVQPLDLgfTITPKSMTEVEPSTALMTTAPPPGHPEVTLPPSD 704
Cdd:PRK10263   816 QYQQPQQPVAPQPQYQQPQQP------VAPQPQDT--LLHPLLMRNGDSRPLHKPTTPLPSLDLLTPPPSE 878
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 251-319 5.04e-15

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 71.24  E-value: 5.04e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217315144  251 EEEPSSMQQEAPALPPESSMESL--TLPNHEVSVQPPGEDQAYY-HLPNITVKPADVEVTITSEPTNETESS 319
Cdd:pfam15779    1 EVEPSPTQQETPTQPPESPKEVVaqPPVHHEVTVPTPGQGQAQHpTLPNVTVQPLDLELTITPEPTKEAEHS 72
LRR_8 pfam13855
Leucine rich repeat;
892-949 5.72e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 70.63  E-value: 5.72e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2217315144  892 EKLILRENNLTELHKDSFEGLLSLQYLDLSCNKIQSIERHTFEPLPFLKFINLSCNVI 949
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
868-1020 2.04e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.28  E-value: 2.04e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  868 TILNFQGNYISYIDGNVwkaYSWT--EKLILRENNLTELHkDSFEGLLSLQYLDLSCNKIQSIERHtFEPLPFLKFINLS 945
Cdd:COG4886    116 ESLDLSGNQLTDLPEEL---ANLTnlKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLS 190

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217315144  946 CNVITELSfgtfQAWHGMQFLHKLILNHNPLTTVEDPyLFKLPALKYLDMGTTlvPLTTLKNILMMTvELEKLIL 1020
Cdd:COG4886    191 NNQITDLP----EPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN--QLTDLPELGNLT-NLEELDL 257
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 689-739 5.24e-12

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 62.77  E-value: 5.24e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2217315144  689 TAPPPGHPEVTLPPSDKGQAQHSHLTQATVQPLDLELTITTKPTTEVKPSP 739
Cdd:pfam15779   23 VAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 874-978 1.13e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.24  E-value: 1.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  874 GNYISYIDGnvwkayswTEKLilreNNLTELH---------------KDSFEGLL-SLQYLDLSCNKIQSIErhTFEPLP 937
Cdd:cd21340     77 GNRISVVEG--------LENL----TNLEELHienqrlppgekltfdPRSLAALSnSLRVLNISGNNIDSLE--PLAPLR 142

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 2217315144  938 FLKFINLSCNVITELS--FGTFQAWHgmqFLHKLILNHNPLTT 978
Cdd:cd21340    143 NLEQLDASNNQISDLEelLDLLSSWP---SLRELDLTGNPVCK 182
Not5 COG5665
CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription];
302-604 1.61e-03

CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription];


Pssm-ID: 444384 [Multi-domain]  Cd Length: 874  Bit Score: 43.11  E-value: 1.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  302 ADVEVTITSEPTNETESSQAQQETPIQFPEEVEPSATQQEAPIEPPVPPMEHELSISEQQQPVQ--PSESPREVESSPTQ 379
Cdd:COG5665    240 PSLLATPPATPATEEKSSQQPKSQPTSPSGGTTPPSTNQLTTSNTPTSTAKAQPQPPTKKQPAKepPSDTASGNPSAPSV 319

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  380 QETPGQPPEHHEVTVSPPGHHQTHHLASPSVSVKPPdvqltiaAEPSAEVgTSLVHQEATTRLSGSgndVEPPAIQHGGP 459
Cdd:COG5665    320 LINSDSPTSEDPATASVPTTEETTAFTTPSSVPSTP-------AEKDTPA-TDLATPVSPTPPETS---VDKKVSPDSAT 388

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  460 PLLPESSEEAGPLAV-QQETSFQSPEPINNENPSPTQQEAAAEHPQTAEegesSLTHQEAPAQTPEFPNVVVAQPPEHSH 538
Cdd:COG5665    389 SSTKSEKEGGTASSPmPPNIAIGAKDDVDATDPSQEAKEYTKNAPMTPE----ADSAPESSVRTEASPSAGSDLEPENTT 464

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217315144  539 LTQAtvqpldlgftiTPESKTEVELSPTMKETPTQPPKKVVPQLRVYQGVTNPTPGQDQAQHPVSP 604
Cdd:COG5665    465 LRDP-----------APNAIPPPEDPSTIGRLSSGDKLANETGPPVIRRDSTPSSTADQSIVGVLA 519
ftsN TIGR02223
cell division protein FtsN; FtsN is a poorly conserved protein active in cell division in a ...
 181-414 2.65e-03

cell division protein FtsN; FtsN is a poorly conserved protein active in cell division in a number of Proteobacteria. The N-terminal 30 residue region tends to by Lys/Arg-rich, and is followed by a membrane-spanning region. This is followed by an acidic low-complexity region of variable length and a well-conserved C-terminal domain of two tandem regions matched by pfam05036 (Sporulation related repeat), found in several cell division and sporulation proteins. The role of FtsN as a suppressor for other cell division mutations is poorly understood; it may involve cell wall hydrolysis. [Cellular processes, Cell division]


Pssm-ID: 274041 [Multi-domain]  Cd Length: 298  Bit Score: 41.99  E-value: 2.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  181 QNEYSSTDTPYPgslppELRVKSDEPPGPSEQVGPSQFHLEPETQNPETLedIQSSSLQQEAPAQLPQLLEEEPSSMQQE 260
Cdd:TIGR02223    3 QRDYVRRGRGAP-----QKKKKNRRLVRATVLIAAILILLFIGGSSGLYL--LTESKQANEPETLQPKNQTENGETAADL 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  261 APAlPPESSMESLTLPNHEVSVQPPGEDQAyyhlpnitVKPADVEVTITSEPTNETESSQAQQETPIQFPEEVEPSATQQ 340
Cdd:TIGR02223   76 PPK-PEERWSYIEELEAREVLINDPEEPSN--------GGGVEESAQLTAEQRQLLEQMQADMRAAEKVLATAPSEQTVA 146

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217315144  341 EAPIEPPVPPMEHELSISEQQQ-PVQPSESPREVESSPTQQETPGQPPEHHEVTVSPpghHQTHHLASPSVSVKP 414
Cdd:TIGR02223  147 VEARKQTAEKKPQKARTAEAQKtPVETEKIASKVKEAKQKQKALPKQTAETQSNSKP---IETAPKADKADKTKP 218
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 734-799 6.22e-03

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 36.96  E-value: 6.22e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217315144  734 EVKPSPTTEETSTQPPDLglaiipePTTETGHSTALEKTTAPRPDRVQTLHRSLTEVTGPPTELEP 799
Cdd:pfam15779    1 EVEPSPTQQETPTQPPES-------PKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLEL 59
 
Name Accession Description Interval E-value
LRRC37AB_C pfam14914
LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of ...
 1468-1578 3.70e-54

LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of the putative Leucine Rich Repeat Containing protein 37A or protein 37B (LRRC37A/B) found in eukaryotes. The Leucine Rich Repeats (LRR) lies in the central region. The gene that encodes this protein is found in the chromosomal position 17q11.2, and its microdeletion results in the disease, neurofibromatosis type-1 (NF1). The function of the protein, LRRC37B is unknown, however experimental data shows expression in the aorta, heart, skeletal muscle, liver and brain during gestation.


Pssm-ID: 464370  Cd Length: 147  Bit Score: 185.70  E-value: 3.70e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144 1468 SPGDQFEIQLTQQLQSLIPNNNVRRLIAHVIRTLKMDCSGAHVQVTCAKLISRTGHLMKLLSGQQEVKASKIEWDTDQWK 1547
Cdd:pfam14914    1 SPGDQFEIQLNQQLLSLIPNVDVRRLISHVIRTLKMDCSEPQMQLACAKLISRTGLLMKLLSEQQEAKVSKADWDTDQWK 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217315144 1548 IENYINESTEAQSEQKEKS------------------------------------LEICCHRRSLQE 1578
Cdd:pfam14914   81 NENYINESTEAQSKQKKQSsreltkevpgygynnklilaisvtvvimiliiilclIEICSHRSASGE 147
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 560-629 1.57e-22

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 92.81  E-value: 1.57e-22
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217315144  560 EVELSPTMKETPTQP---PKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEPTTEVGHST 629
Cdd:pfam15779    1 EVEPSPTQQETPTQPpesPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 206-704 5.04e-15

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 81.28  E-value: 5.04e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  206 PPGPSEQVGPSQFHLE----PETQNPETLEDIQSSSLQQEAPAQLPQLLEEEPssMQQEAPALPPESSMESLTLPNHEVS 281
Cdd:PRK10263   344 PPVASVDVPPAQPTVAwqpvPGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEP--LQQPVQPQQPYYAPAAEQPAQQPYY 421

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  282 VQPPGEDQAYYHLPNITVKPA--------DVEVTITSEPTNETESSQAQ---QETPIQFPEEVEPSATQQEAP----IEP 346
Cdd:PRK10263   422 APAPEQPAQQPYYAPAPEQPVagnawqaeEQQSTFAPQSTYQTEQTYQQpaaQEPLYQQPQPVEQQPVVEPEPvveeTKP 501

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  347 PVPPMEHELSISEQQ-----------QPV-QPSESPREVESSPTQQETPGQPPEHHEVTVSP--PGHHQTHHLASPSVSV 412
Cdd:PRK10263   502 ARPPLYYFEEVEEKRarereqlaawyQPIpEPVKEPEPIKSSLKAPSVAAVPPVEAAAAVSPlaSGVKKATLATGAAATV 581

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  413 KPPDVQLTIAAEPSAEVGTSLVHQ-------EATTRLSGSGNDVEPPAIQhggppLLPESSEEAGPLAVQQETSFQSPEP 485
Cdd:PRK10263   582 AAPVFSLANSGGPRPQVKEGIGPQlprpkriRVPTRRELASYGIKLPSQR-----AAEEKAREAQRNQYDSGDQYNDDEI 656

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  486 INNENPSPTQQEAAAEHPQTAEEGESSLTHQ----EAPAQTPEFPNVVVAQPPEHSHLTQATVQPLDLG-FTITP----- 555
Cdd:PRK10263   657 DAMQQDELARQFAQTQQQRYGEQYQHDVPVNaedaDAAAEAELARQFAQTQQQRYSGEQPAGANPFSLDdFEFSPmkall 736

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  556 -ESKTEVELSPT-MKETPTQPPKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEpTTEVGHSTPPKR 633
Cdd:PRK10263   737 dDGPHEPLFTPIvEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQ-YQQPQQPVAPQP 815

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217315144  634 TIVSPKHPEVTLPHPDQVQTQhshltrATVQPLDLgfTITPKSMTEVEPSTALMTTAPPPGHPEVTLPPSD 704
Cdd:PRK10263   816 QYQQPQQPVAPQPQYQQPQQP------VAPQPQDT--LLHPLLMRNGDSRPLHKPTTPLPSLDLLTPPPSE 878
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 251-319 5.04e-15

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 71.24  E-value: 5.04e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217315144  251 EEEPSSMQQEAPALPPESSMESL--TLPNHEVSVQPPGEDQAYY-HLPNITVKPADVEVTITSEPTNETESS 319
Cdd:pfam15779    1 EVEPSPTQQETPTQPPESPKEVVaqPPVHHEVTVPTPGQGQAQHpTLPNVTVQPLDLELTITPEPTKEAEHS 72
LRR_8 pfam13855
Leucine rich repeat;
892-949 5.72e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 70.63  E-value: 5.72e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2217315144  892 EKLILRENNLTELHKDSFEGLLSLQYLDLSCNKIQSIERHTFEPLPFLKFINLSCNVI 949
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
868-1020 2.04e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.28  E-value: 2.04e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  868 TILNFQGNYISYIDGNVwkaYSWT--EKLILRENNLTELHkDSFEGLLSLQYLDLSCNKIQSIERHtFEPLPFLKFINLS 945
Cdd:COG4886    116 ESLDLSGNQLTDLPEEL---ANLTnlKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLS 190

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217315144  946 CNVITELSfgtfQAWHGMQFLHKLILNHNPLTTVEDPyLFKLPALKYLDMGTTlvPLTTLKNILMMTvELEKLIL 1020
Cdd:COG4886    191 NNQITDLP----EPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN--QLTDLPELGNLT-NLEELDL 257
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 352-429 2.54e-14

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 69.31  E-value: 2.54e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217315144  352 EHELSISEQQQPVQPSESPREVEssptqqetpGQPPEHHEVTVSPPGHHQTHHLASPSVSVKPPDVQLTIAAEPSAEV 429
Cdd:pfam15779    1 EVEPSPTQQETPTQPPESPKEVV---------AQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEA 69
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 689-739 5.24e-12

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 62.77  E-value: 5.24e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2217315144  689 TAPPPGHPEVTLPPSDKGQAQHSHLTQATVQPLDLELTITTKPTTEVKPSP 739
Cdd:pfam15779   23 VAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
868-1006 1.63e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 1.63e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  868 TILNFQGNYISYIDGNVWKAYSwTEKLILRENNLTELHkDSFEGLLSLQYLDLSCNKIQSIERhTFEPLPFLKFINLSCN 947
Cdd:COG4886    162 KSLDLSNNQLTDLPEELGNLTN-LKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNN 238

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217315144  948 VITELSfgtfqAWHGMQFLHKLILNHNPLTTVedPYLFKLPALKYLDMGTTlvPLTTLK 1006
Cdd:COG4886    239 QLTDLP-----ELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNN--QLTDLK 288
PHA03247 PHA03247
large tegument protein UL36; Provisional
 190-752 5.72e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.04  E-value: 5.72e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  190 PYPGSLPPELRVKS-------DEPPGPSEQVGPSQFHLEPETQNPETLEDIQSSSLQQEAPAQLPqlleeePSSMQQEAP 262
Cdd:PHA03247  2554 PLPPAAPPAAPDRSvppprpaPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLP------PDTHAPDPP 2627

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  263 alPPESSMESLTLPNHEVSVQPPGEDQAYYHLPNITVKPAdvEVTITSEPTNEteSSQAQQETPIQFPEEVEPSATQQEA 342
Cdd:PHA03247  2628 --PPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPR--RARRLGRAAQA--SSPPQRPRRRAARPTVGSLTSLADP 2701

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  343 PIEPPVPPMEHELSISEQQQPVQPSESPREVESSPTQQETPGQP-----PEHHEVTVSPPGHHQTHHLASPSVSVKPPDV 417
Cdd:PHA03247  2702 PPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPagpatPGGPARPARPPTTAGPPAPAPPAAPAAGPPR 2781

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  418 QLTIAAEPSAevgtslvhQEATTRLSGSGNDVEPPAIQHGGPPLLPESSEEAGPLAVQQetsfqSPEPINNENPSPTQQE 497
Cdd:PHA03247  2782 RLTRPAVASL--------SESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPT-----SAQPTAPPPPPGPPPP 2848

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  498 AAAEHPQTAEEGESSlthQEAPAQTPefPNVVVAQP-PEHSHLTQATVQPLDLGFTITPESKtEVELSPTMKETPTQPPK 576
Cdd:PHA03247  2849 SLPLGGSVAPGGDVR---RRPPSRSP--AAKPAAPArPPVRRLARPAVSRSTESFALPPDQP-ERPPQPQAPPPPQPQPQ 2922

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  577 KVVPQLRVYQgvtNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEPTTEVGHSTPPKRTIVSPKHPEVTLPHPDQVQTQHS 656
Cdd:PHA03247  2923 PPPPPQPQPP---PPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGH 2999

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  657 HLTRATVQPLDLGFTITPksmtevepstalmttAPPPGHPEVTL-PPSDKGQAQHSHLTQATVQPLDLEltiTTKPTTEV 735
Cdd:PHA03247  3000 SLSRVSSWASSLALHEET---------------DPPPVSLKQTLwPPDDTEDSDADSLFDSDSERSDLE---ALDPLPPE 3061

                          570
                   ....*....|....*..
gi 2217315144  736 KPSPTTEETSTQPPDLG 752
Cdd:PHA03247  3062 PHDPFAHEPDPATPEAG 3078
LRR_8 pfam13855
Leucine rich repeat;
914-976 8.95e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.69  E-value: 8.95e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217315144  914 SLQYLDLSCNKIQSIERHTFEPLPFLKFINLSCNVITELSFGTFqawHGMQFLHKLILNHNPL 976
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAF---SGLPSLRYLDLSGNRL 61
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 508-565 1.95e-10

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 58.14  E-value: 1.95e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217315144  508 EGESSLTHQEAPAQTPEFPNVVVAQPP---------------EHSHLTQATVQPLDLGFTITPESKTEVELSP 565
Cdd:pfam15779    1 EVEPSPTQQETPTQPPESPKEVVAQPPvhhevtvptpgqgqaQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 307-739 1.21e-09

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 63.25  E-value: 1.21e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  307 TITSEPTNETES-SQAQQETPIQFPEEVEpsaTQQEAPIEPPVPPMEHELSISEQQQPVQPSESPREVE--SSPTQQETP 383
Cdd:pfam03154  147 SIPSPQDNESDSdSSAQQQILQTQPPVLQ---AQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPatSQPPNQTQS 223

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  384 GQPPeHHEVTVSPPGHHQthHLASPsvsvKPPDVQLTIAAEPSAEVGTSLVHQEATTRLSGSGNDVE--PPAIQHGGPP- 460
Cdd:pfam03154  224 TAAP-HTLIQQTPTLHPQ--RLPSP----HPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQtgPSHMQHPVPPq 296

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  461 ---LLPESSEEAGPLAVQQETSFQSPEPINNENPSPTQQEAAAEHPQTAEEGESSLTHQEAPAQTPeFPNVVVAQPPEH- 536
Cdd:pfam03154  297 pfpLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTP-IPQLPNPQSHKHp 375

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  537 SHLTQATVQPLDLGFTITPESKTEVELSPTMKETPTQPPKKVVPQlrvyqgvtnptpGQDQAQHPVSPSVTVQLLDLGLT 616
Cdd:pfam03154  376 PHLSGPSPFQMNSNLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQ------------SQQLPPPPAQPPVLTQSQSLPPP 443

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  617 ITPEPTTEVGHSTPPKRTIvsPKHPEVTLPHPdqvqtqhshltraTVQPLDLGFTITPKSMTEVEP--STALMTTAPPPG 694
Cdd:pfam03154  444 AASHPPTSGLHQVPSQSPF--PQHPFVPGGPP-------------PITPPSGPPTSTSSAMPGIQPpsSASVSSSGPVPA 508

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*
gi 2217315144  695 HPEVTLPPsdkgqaqhshlTQATVQPLDLELTITTKPTTEVKPSP 739
Cdd:pfam03154  509 AVSCPLPP-----------VQIKEEALDEAEEPESPPPPPRSPSP 542
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
900-1020 1.28e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.18  E-value: 1.28e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  900 NLTEL---HKDSFEGLLSLQYLDLSCNKIQSIERHtFEPLPFLKFINLSCNVITEL--SFGTFQAwhgmqfLHKLILNHN 974
Cdd:COG4886     97 NLTELdlsGNEELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLpePLGNLTN------LKSLDLSNN 169

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 2217315144  975 PLTTVEDPyLFKLPALKYLDMGTTlvPLTTLKNILMMTVELEKLIL 1020
Cdd:COG4886    170 QLTDLPEE-LGNLTNLKELDLSNN--QITDLPEPLGNLTNLEELDL 212
rne PRK10811
ribonuclease E; Reviewed
 223-593 2.18e-07

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 56.20  E-value: 2.18e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  223 ETQNPETLEDIQSSSLQQEAPAQLPQLL-EEEPSSMQQEAPALPPEssmesltlpnHEVSVQPPGEDQAYYHLPNITVKP 301
Cdd:PRK10811   655 ESQQAEVTEKARTQDEQQQAPRRERQRRrNDEKRQAQQEAKALNVE----------EQSVQETEQEERVQQVQPRRKQRQ 724

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  302 ADVEVTITSEPTNETESSQAQQETPIQFPEEVEPSATQQEAPIEPPV---PPMEHELSISEQQQ-----PVQPSESPREV 373
Cdd:PRK10811   725 LNQKVRIEQSVAEEAVAPVVEETVAAEPVVQEVPAPRTELVKVPLPVvaqTAPEQDEENNAENRdnngmPRRSRRSPRHL 804

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  374 ------------ESSPTQQETP----GQPPE--------HHEVTvsPPGHHQTHHLASPSVSVKPPDVQLTIAAEPSAEV 429
Cdd:PRK10811   805 rvsgqrrrryrdERYPTQSPMPltvaCASPEmasgkvwiRYPVV--RPQDVQVEEQREAEEVQVQPVVAEVPVAAAVEPV 882

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  430 GTSLVHQEATTrlsgsgnDVEPPAIQHGGPPLLPESSEEAGPLAVQqetsfqspEPInNENPSPTQQEAAAEHPQTAEEG 509
Cdd:PRK10811   883 VSAPVVEAVAE-------VVEEPVVVAEPQPEEVVVVETTHPEVIA--------APV-TEQPQVITESDVAVAQEVAEHA 946

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  510 ESSLTHQEAPAQTPEFPNVVVAQPPEHSHLTQATVQPldlgfTITPESKTEVELSPTMKETPTQPPKKVVPQLRVYQGVT 589
Cdd:PRK10811   947 EPVVEPQDETADIEEAAETAEVVVAEPEVVAQPAAPV-----VAEVAAEVETVTAVEPEVAPAQVPEATVEHNHATAPMT 1021


                   ....*
gi 2217315144  590 N-PTP 593
Cdd:PRK10811  1022 RaPAP 1026
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
823-1020 2.57e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.94  E-value: 2.57e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  823 KASTSTNICELCTCGDEMLSCIDLNPEQRLRQVPVPEPNTHNGTFTILNFQGNYISYIDGNVWKAYSWTEKLILRENNLT 902
Cdd:COG4886      8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  903 ELhkDSFEGLLSLQYLDLSCNKiqsierhTFEPLPFLKFINLSCNVITELSFGTFQawhgMQFLHKLILNHNPLTTVEDP 982
Cdd:COG4886     88 GL--TDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELAN----LTNLKELDLSNNQLTDLPEP 154

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 2217315144  983 yLFKLPALKYLDMGTTlvPLTTLKNILMMTVELEKLIL 1020
Cdd:COG4886    155 -LGNLTNLKSLDLSNN--QLTDLPEELGNLTNLKELDL 189
PHA03247 PHA03247
large tegument protein UL36; Provisional
 315-811 2.69e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 2.69e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  315 ETESSQAQQETPIqFPEEVEPSATQQEAPIEPPVPpmehelsiseqqQPVQPSESPRE----VESSPTQQETPGQPPEhh 390
Cdd:PHA03247  2542 ELASDDAGDPPPP-LPPAAPPAAPDRSVPPPRPAP------------RPSEPAVTSRArrpdAPPQSARPRAPVDDRG-- 2606

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  391 evtvSPPGHHQTHHLASPSVSVKPPDVQLTIAAEPSAEVGTSLVHQEATTRLSGSGNDVEPP--------AIQHGGPPLL 462
Cdd:PHA03247  2607 ----DPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPrrarrlgrAAQASSPPQR 2682

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  463 PEssEEAGPLAVQQETSFQSPEPINNE-NPSPTQQEAAAEHPQTAeegesslthQEAPAQTPEFPNVVVAQPPEHSHLTQ 541
Cdd:PHA03247  2683 PR--RRAARPTVGSLTSLADPPPPPPTpEPAPHALVSATPLPPGP---------AAARQASPALPAAPAPPAVPAGPATP 2751

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  542 ATVQPldlgftitpesktevelsPTMKETPTQPPKKVVPQLRvyqgvtnPTPGQDQAQHPVSPSVTVQLLDLGLTITPEP 621
Cdd:PHA03247  2752 GGPAR------------------PARPPTTAGPPAPAPPAAP-------AAGPPRRLTRPAVASLSESRESLPSPWDPAD 2806

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  622 TTEVghSTPPKRTIVSPKHPEVTLPHPDQVQTQHSHLTRATVQP-LDLGFTITPKS-MTEVEPSTALMTTAPPPGHPEVT 699
Cdd:PHA03247  2807 PPAA--VLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPsLPLGGSVAPGGdVRRRPPSRSPAAKPAAPARPPVR 2884

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  700 ------LPPSDKGQAQHSHLTQATVQPlDLELTITTKPTTEVKPSPTTEETSTQPPDLGLAIIPEPTTETGHSTAlektt 773
Cdd:PHA03247  2885 rlarpaVSRSTESFALPPDQPERPPQP-QAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGA----- 2958

                          490       500       510
                   ....*....|....*....|....*....|....*...
gi 2217315144  774 APRPdrvQTLHRSLTEVTGPPTELEPAQDSLVQSESYT 811
Cdd:PHA03247  2959 VPQP---WLGALVPGRVAVPRFRVPQPAPSREAPASST 2993
PHA03247 PHA03247
large tegument protein UL36; Provisional
 68-535 3.24e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.25  E-value: 3.24e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144   68 PRESPHAPTLPADPwdfDHLGPSASSEMPAPPQESTEnlvPFLDTWDSAGEQPLEPEQFLASqqdlkdklSPQERLPVSP 147
Cdd:PHA03247  2676 ASSPPQRPRRRAAR---PTVGSLTSLADPPPPPPTPE---PAPHALVSATPLPPGPAAARQA--------SPALPAAPAP 2741

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  148 KKLKKDPAqrwslaeIIGITRQLSTPQSqkqtlqneyssTDTPyPGSLPPELRVKSDEPPGPSEQVGPSQFHLE--PETQ 225
Cdd:PHA03247  2742 PAVPAGPA-------TPGGPARPARPPT-----------TAGP-PAPAPPAAPAAGPPRRLTRPAVASLSESREslPSPW 2802

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  226 NPETLEDIQSSSLQQEAPAQLPQLLEEEPSSMQQEAPALPPESSMESLTLpnhEVSVQPPGedqayyhlPNITVKPADVE 305
Cdd:PHA03247  2803 DPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPL---GGSVAPGG--------DVRRRPPSRSP 2871

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  306 VTITSEPTNETESSQAQqetpiqfpeevePSATQQEAPIepPVPPmehelsiSEQQQPVQPSESPREVESSPTQQETPGQ 385
Cdd:PHA03247  2872 AAKPAAPARPPVRRLAR------------PAVSRSTESF--ALPP-------DQPERPPQPQAPPPPQPQPQPPPPPQPQ 2930

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  386 PPEHHEVTVSPPGHHQTHHLASPSVSVKPPDVQLTIAAEPSAEVGTSLVHQEATTRLSGSgndvEPPAIQHGGPplLPES 465
Cdd:PHA03247  2931 PPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPA----SSTPPLTGHS--LSRV 3004

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217315144  466 SEEAGPLAVQQETsfqSPEPINNEN---PSPTQQEAAAEHPQTAEEGESSLthqEAPAQTPEFPNVVVAQPPE 535
Cdd:PHA03247  3005 SSWASSLALHEET---DPPPVSLKQtlwPPDDTEDSDADSLFDSDSERSDL---EALDPLPPEPHDPFAHEPD 3071
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
868-1010 3.37e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.47  E-value: 3.37e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  868 TILNFQGNYISYIDGNVwKAYSWTEKLILRENNLTELhkDSFEGLLSLQYLDLSCNKIQSIErhTFEPLPFLKFINLSCN 947
Cdd:COG4886    208 EELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNN 282

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217315144  948 VITELSFGTFQAWHGMQFLHKLILNHNPLTTVEDPYLFKLPALKYLDMGTTLVPLTTLKNILM 1010
Cdd:COG4886    283 QLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLS 345
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 49-383 8.61e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 50.92  E-value: 8.61e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144   49 LTSNPLGPPESWSSHSSHfPRESPHAPtLPADPWDFdHLGPSaSSEMPAPPQestenlvPFLDTWDSAGEQ-PLEPEQFL 127
Cdd:pfam03154  249 LQPMTQPPPPSQVSPQPL-PQPSLHGQ-MPPMPHSL-QTGPS-HMQHPVPPQ-------PFPLTPQSSQSQvPPGPSPAA 317

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  128 ASQQDLKDKLSPQERLPVSPKKLKKDPAQRWSLAeIIGITRQLSTPQSQKQTLQneysSTDTPYPGSLPPELRVKSDEPP 207
Cdd:pfam03154  318 PGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLS-MPHIKPPPTTPIPQLPNPQ----SHKHPPHLSGPSPFQMNSNLPP 392

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  208 GPSEQVGPSQFHLEPETQNPETLEDIQSSSLQQEAPAQLPQLleeepssmqQEAPALPPESSMESLTLPNHEVSVQPPGE 287
Cdd:pfam03154  393 PPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPVL---------TQSQSLPPPAASHPPTSGLHQVPSQSPFP 463

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  288 DQAYYHLPNITVKPAdvevtitSEPTNETESSQaqqeTPIQFPEEVEPSATQQ-EAPIEPPVPPME-HELSISEQQQPVQ 365
Cdd:pfam03154  464 QHPFVPGGPPPITPP-------SGPPTSTSSAM----PGIQPPSSASVSSSGPvPAAVSCPLPPVQiKEEALDEAEEPES 532

                          330
                   ....*....|....*...
gi 2217315144  366 PSESPREVESSPTQQETP 383
Cdd:pfam03154  533 PPPPPRSPSPEPTVVNTP 550
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 874-978 1.13e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.24  E-value: 1.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  874 GNYISYIDGnvwkayswTEKLilreNNLTELH---------------KDSFEGLL-SLQYLDLSCNKIQSIErhTFEPLP 937
Cdd:cd21340     77 GNRISVVEG--------LENL----TNLEELHienqrlppgekltfdPRSLAALSnSLRVLNISGNNIDSLE--PLAPLR 142

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 2217315144  938 FLKFINLSCNVITELS--FGTFQAWHgmqFLHKLILNHNPLTT 978
Cdd:cd21340    143 NLEQLDASNNQISDLEelLDLLSSWP---SLRELDLTGNPVCK 182
rne PRK10811
ribonuclease E; Reviewed
 299-538 1.62e-05

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 50.04  E-value: 1.62e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  299 VKPADVEVTITSEPTNETESSQAQQETPIQFPEEVEPSATQQEAPIEPPVPPMEHElsiseqqqPVQPSESPREvesspt 378
Cdd:PRK10811   848 VRPQDVQVEEQREAEEVQVQPVVAEVPVAAAVEPVVSAPVVEAVAEVVEEPVVVAE--------PQPEEVVVVE------ 913

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  379 qqetpgqppEHHEVTVSPPGHHQTHHLASPSVSVKPPDVQLTIAAEPSAEVGTSLVHQEATTrlsgsgndveppaiqhgg 458
Cdd:PRK10811   914 ---------TTHPEVIAAPVTEQPQVITESDVAVAQEVAEHAEPVVEPQDETADIEEAAETA------------------ 966

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  459 PPLLPESSEEAGPLAVQQETsfqSPEPINNENPSPTQQEAAAEHPQTAEEGESSLTHQEAPAqtPEFpnvvVAQPPEHSH 538
Cdd:PRK10811   967 EVVVAEPEVVAQPAAPVVAE---VAAEVETVTAVEPEVAPAQVPEATVEHNHATAPMTRAPA--PEY----VPEAPRHSD 1037
rne PRK10811
ribonuclease E; Reviewed
 215-418 4.95e-05

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 48.11  E-value: 4.95e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  215 PSQFHLEPETQNPETLEDIQSSSLQQEAPAQlpqllEEEPSSMQQEAPALPPEssmesltlPNHEVSVQPPGEDQAYYHL 294
Cdd:PRK10811   850 PQDVQVEEQREAEEVQVQPVVAEVPVAAAVE-----PVVSAPVVEAVAEVVEE--------PVVVAEPQPEEVVVVETTH 916

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  295 PNITVKPADVEVTITSEPTNETESSQAQQETPIQFPEEVEPSATQQEAPIEPPVPpmehelsisEQQQPVQPSESPREVE 374
Cdd:PRK10811   917 PEVIAAPVTEQPQVITESDVAVAQEVAEHAEPVVEPQDETADIEEAAETAEVVVA---------EPEVVAQPAAPVVAEV 987

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 2217315144  375 SSPTQQETPGQPPEHHEVTVSPPGHHqtHHLASPSVSVKPPDVQ 418
Cdd:PRK10811   988 AAEVETVTAVEPEVAPAQVPEATVEH--NHATAPMTRAPAPEYV 1029
PRK14949 PRK14949
DNA polymerase III subunits gamma and tau; Provisional
 154-602 3.15e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237863 [Multi-domain]  Cd Length: 944  Bit Score: 45.49  E-value: 3.15e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  154 PAQRWSLAEIIGITRQLSTPQSQKQTLQNEYSSTDTPYPGSLPPElrvksdEPPGPSEQVGPSQFHLEPETQNP-ETLED 232
Cdd:PRK14949   362 PVKRWQVDDPAEISLPEGQTPSALAAAVQAPHANEPQFVNAAPAE------KKTALTEQTTAQQQVQAANAEAVaEADAS 435

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  233 IQSSSLQQEAPAQLPQLLEEEPSSMQ---QEAPALPPESSMESLTLPNHEVSVQPPGEDQAYYHlPNITVKPADVEVTIT 309
Cdd:PRK14949   436 AEPADTVEQALDDESELLAALNAEQAvilSQAQSQGFEASSSLDADNSAVPEQIDSTAEQSVVN-PSVTDTQVDDTSASN 514

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  310 SEPTNETESSQAQQETPIQFPEEVEPSATQQEAPIEPPVPPMEHElsISEQQQPVQPSESPREVESSPTQQETPGQPPEH 389
Cdd:PRK14949   515 NSAADNTVDDNYSAEDTLESNGLDEGDYAQDSAPLDAYQDDYVAF--SSESYNALSDDEQHSANVQSAQSAAEAQPSSQS 592

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  390 HEVTVSPPghhqthhlaSPSVSVKPPDV-QLTIAAEPS--AEVGTSLVHQEATTRLSGSGNDVEPPAIQHGGPPLLPESS 466
Cdd:PRK14949   593 LSPISAVT---------TAAASLADDDIlDAVLAARDSllSDLDALSPKEGDGKKSSADRKPKTPPSRAPPASLSKPASS 663

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  467 EEAGPLAVQQETSFQS-PEPINNENPSPTQ-QEAAAEHPQT----------AEEGESSLTHQEAPAQTPEFPNVV----- 529
Cdd:PRK14949   664 PDASQTSASFDLDPDFeLATHQSVPEAALAsGSAPAPPPVPdpydrppweeAPEVASANDGPNNAAEGNLSESVEdasns 743

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217315144  530 ----VAQPPEHSHLTQATVQPldlgftitpesktevelsPTMKETPTQPPKKVVPQlrvyQGVTNPTPGQDQAQHPV 602
Cdd:PRK14949   744 elqaVEQQATHQPQVQAEAQS------------------PASTTALTQTSSEVQDT----ELNLVLLSSGSITGHPL 798
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 190-468 4.57e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 45.03  E-value: 4.57e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  190 PYPGSLPPELRVKSDEPPGPSEQVGPSQFHLEP-----ET-QNPETLEDIQ-SSSLQQEAPAQLPQLLEEEPSSMQQEAP 262
Cdd:pfam09770  107 PAARAAQSSAQPPASSLPQYQYASQQSQQPSKPvrtgyEKyKEPEPIPDLQvDASLWGVAPKKAAAPAPAPQPAAQPASL 186

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  263 ALPPESSMeSLtlpnHEVsvqppgEDQAYYHLPNITVKPADVEVTITSEPTnetessQAQQETPIQFPEEVEPSATQQEA 342
Cdd:pfam09770  187 PAPSRKMM-SL----EEV------EAAMRAQAKKPAQQPAPAPAQPPAAPP------AQQAQQQQQFPPQIQQQQQPQQQ 249

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  343 PIEPPvPPMEHELSISEQQQPVQPSESPREVESSPTQQETPGQPPehhevtvsPPGHHQTHHLASPSVsvkPPDVQLTIA 422
Cdd:pfam09770  250 PQQPQ-QHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPP--------PVPVQPTQILQNPNR---LSAARVGYP 317

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 2217315144  423 AEPSAEVGTSLVHQEATTRLSGSGNdvePPAIQHggPPLLPESSEE 468
Cdd:pfam09770  318 QNPQPGVQPAPAHQAHRQQGSFGRQ---APIITH--PQQLAQLSEE 358
PHA03378 PHA03378
EBNA-3B; Provisional
 171-646 8.57e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 44.29  E-value: 8.57e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  171 STPQSQKQT--LQNEYSSTDTPYPGSLPPELRVKSdEPPGPSEQVGPSQFHLEP--ETQNPETLEDIQSSSLQQEAPAQL 246
Cdd:PHA03378   443 ATPHSQAPTvvLHRPPTQPLEGPTGPLSVQAPLEP-WQPLPHPQVTPVILHQPPaqGVQAHGSMLDLLEKDDEDMEQRVM 521

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  247 PQLLEEEPSsmQQEAPALPPESSMESLTLPNHEVSVQPPGEDQAyyhLPNITVKPADVEvTITSEPTNETES---SQAQQ 323
Cdd:PHA03378   522 ATLLPPSPP--QPRAGRRAPCVYTEDLDIESDEPASTEPVHDQL---LPAPGLGPLQIQ-PLTSPTTSQLASsapSYAQT 595

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  324 ETPIQFPEEVEPSATQQEAPIEPPVPPMEHELSISEQQQPVQPSESPREVESSPTQQETPGQPPEHHEVTVSPPGH---- 399
Cdd:PHA03378   596 PWPVPHPSQTPEPPTTQSHIPETSAPRQWPMPLRPIPMRPLRMQPITFNVLVFPTPHQPPQVEITPYKPTWTQIGHipyq 675

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  400 -HQTHHLASPSVS-----VKPPDVQLTIAAEPSAEVGTSLVHQEATTRL---SGSGNDVEPPAiqhGGPPLLPESSEEAG 470
Cdd:PHA03378   676 pSPTGANTMLPIQwapgtMQPPPRAPTPMRPPAAPPGRAQRPAAATGRArppAAAPGRARPPA---AAPGRARPPAAAPG 752

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  471 PLAVQQETSFQSPEPINNEN-PSPTQQEAAAEHPQTAEEGESslTHQEAPAQTPEFPNVVVAQPPEHSHLTQATVQPLDL 549
Cdd:PHA03378   753 RARPPAAAPGRARPPAAAPGaPTPQPPPQAPPAPQQRPRGAP--TPQPPPQAGPTSMQLMPRAAPGQQGPTKQILRQLLT 830

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  550 GFTIT--PESKTEVELSPTMKETPTQPPK-----KVVPQLRVYQGVTNPT--PGQDQAQHPVSPSvtvqlldlglTITPE 620
Cdd:PHA03378   831 GGVKRgrPSLKKPAALERQAAAGPTPSPGsgtsdKIVQAPVFYPPVLQPIqvMRQLGSVRAAAAS----------TVTQA 900

                          490       500
                   ....*....|....*....|....*.
gi 2217315144  621 PTTEVGhstppKRTIVSPKHPEVTLP 646
Cdd:PHA03378   901 PTEYTG-----ERRGVGPMHPTDIPP 921
PHA03377 PHA03377
EBNA-3C; Provisional
 295-748 8.89e-04

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 44.27  E-value: 8.89e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  295 PNITVKPADVEVTITSEPTNETESSQAqqetpiqFPEEVEPSaTQQEAPIEPPVP-PMEHELSISEQQQPV--------- 364
Cdd:PHA03377   422 PTPKTHPVKRTLVKTSGRSDEAEQAQS-------TPERPGPS-DQPSVPVEPAHLtPVEHTTVILHQPPQSpptvaikpa 493

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  365 -QPSESPR--------------EVESS--PTQQETPGQPPEHHEVTVSPPGHHQTHHL---ASPSVSVKP--------PD 416
Cdd:PHA03377   494 pPPSRRRRgacvvydddiieviDVETTeeEESVTQPAKPHRKVQDGFQRSGRRQKRATppkVSPSDRGPPkasppvmaPP 573

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  417 VQLTIAAEPSAEVGTSLVHQEATTRLSGSGNDVEPPAIQHGGPPLLPESSEEAGPLAVQQETSFQSPEPINNENPSPTQQ 496
Cdd:PHA03377   574 STGPRVMATPSTGPRDMAPPSTGPRQQAKCKDGPPASGPHEKQPPSSAPRDMAPSVVRMFLRERLLEQSTGPKPKSFWEM 653

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  497 EAAAEHPQTAEEGESSL--THQEAPAQTPEFPNVVV--------AQPPEHSHL-----TQATVQPLDLGFTiTPESKTEV 561
Cdd:PHA03377   654 RAGRDGSGIQQEPSSRRqpATQSTPPRPSWLPSVFVlpsvdagrAQPSEESHLssmspTQPISHEEQPRYE-DPDDPLDL 732

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  562 ELSPtmkETPTQPPKKvvpqlrvyqgvtNPTPGQDQAQHPVSPSVTVQlldlglTITPEPTTEVGHSTPPKRTIVSPKHP 641
Cdd:PHA03377   733 SLHP---DQAPPPSHQ------------APYSGHEEPQAQQAPYPGYW------EPRPPQAPYLGYQEPQAQGVQVSSYP 791

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  642 EVTLPHPDQVQTQ-HSHLTRATVQPLDLGFTITPKSMTEVEPSTALMTTA---------PPPGHPEVTLPPSDKGQAQHS 711
Cdd:PHA03377   792 GYAGPWGLRAQHPrYRHSWAYWSQYPGHGHPQGPWAPRPPHLPPQWDGSAghgqdqvsqFPHLQSETGPPRLQLSQVPQL 871

                          490       500       510
                   ....*....|....*....|....*....|....*..
gi 2217315144  712 HLTQATVQPLDLELTiTTKPTTEVKPSPTTEETSTQP 748
Cdd:PHA03377   872 PYSQTLVSSSAPSWS-SPQPRAPIRPIPTRFPPPPMP 907
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 914-954 1.00e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.38  E-value: 1.00e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2217315144  914 SLQYLDLSCNKIQSIErhTFEPLPFLKFINLS-CNVITELSF 954
Cdd:pfam12799    2 NLEVLDLSNNQITDIP--PLAKLPNLETLDLSgNNKITDLSD 41
PRK14960 PRK14960
DNA polymerase III subunit gamma/tau;
301-510 1.17e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237868 [Multi-domain]  Cd Length: 702  Bit Score: 43.50  E-value: 1.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  301 PADVEVTITSEPTNETE---SSQAQQETPIQFPEEVEPSATQQEAPIEPPVPPMEHELSISEQQQPvQPSESPrEVESSP 377
Cdd:PRK14960   363 PNEILVSEPVQQNGQAEvglNSQAQTAQEITPVSAVQPVEVISQPAMVEPEPEPEPEPEPEPEPEP-EPEPEP-EPEPEP 440

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  378 tqqetpgQPPEHHEVTVSPPGHHQTHHLASPSVSvkppdVQLTIAAEPSAEVGTS-LVHQEATTRLsgsgNDVEPPAIQH 456
Cdd:PRK14960   441 -------EPQPNQDLMVFDPNHHELIGLESAVVQ-----ETVSVLEEDFIPVPEQkLVQVQAETQV----KQIEPEPAST 504

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2217315144  457 GGPPLLPESSEEAGPLAVQQETSFQSPEPINNENP----SPTQQEAAAEHPQTAEEGE 510
Cdd:PRK14960   505 AEPIGLFEASSAEFSLAQDTSAYDLVSEPVIEQQSlvqaEIVETVAVVKEPNATDNSQ 562
Not5 COG5665
CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription];
302-604 1.61e-03

CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription];


Pssm-ID: 444384 [Multi-domain]  Cd Length: 874  Bit Score: 43.11  E-value: 1.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  302 ADVEVTITSEPTNETESSQAQQETPIQFPEEVEPSATQQEAPIEPPVPPMEHELSISEQQQPVQ--PSESPREVESSPTQ 379
Cdd:COG5665    240 PSLLATPPATPATEEKSSQQPKSQPTSPSGGTTPPSTNQLTTSNTPTSTAKAQPQPPTKKQPAKepPSDTASGNPSAPSV 319

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  380 QETPGQPPEHHEVTVSPPGHHQTHHLASPSVSVKPPdvqltiaAEPSAEVgTSLVHQEATTRLSGSgndVEPPAIQHGGP 459
Cdd:COG5665    320 LINSDSPTSEDPATASVPTTEETTAFTTPSSVPSTP-------AEKDTPA-TDLATPVSPTPPETS---VDKKVSPDSAT 388

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  460 PLLPESSEEAGPLAV-QQETSFQSPEPINNENPSPTQQEAAAEHPQTAEegesSLTHQEAPAQTPEFPNVVVAQPPEHSH 538
Cdd:COG5665    389 SSTKSEKEGGTASSPmPPNIAIGAKDDVDATDPSQEAKEYTKNAPMTPE----ADSAPESSVRTEASPSAGSDLEPENTT 464

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217315144  539 LTQAtvqpldlgftiTPESKTEVELSPTMKETPTQPPKKVVPQLRVYQGVTNPTPGQDQAQHPVSP 604
Cdd:COG5665    465 LRDP-----------APNAIPPPEDPSTIGRLSSGDKLANETGPPVIRRDSTPSSTADQSIVGVLA 519
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 892-929 2.06e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.61  E-value: 2.06e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2217315144  892 EKLILRENNLTELhkDSFEGLLSLQYLDLS-CNKIQSIE 929
Cdd:pfam12799    4 EVLDLSNNQITDI--PPLAKLPNLETLDLSgNNKITDLS 40
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 471-802 2.42e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.60  E-value: 2.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  471 PLAVQQETSFQSPEpinNENPSPTQQEAAAEHPQTAEEGESSLTHQEAPAQtpefpNVVVAQPPEHSHLTQATVQPLDLG 550
Cdd:pfam05109  449 PSSTHVPTNLTAPA---STGPTVSTADVTSPTPAGTTSGASPVTPSPSPRD-----NGTESKAPDMTSPTSAVTTPTPNA 520

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  551 FTITPESKTEV--ELSPTM-KETPTQPPKKVVPQLRV-YQGVTNPTPGQD-QAQHPVSPSVTVQlldlglTITPEPTT-E 624
Cdd:pfam05109  521 TSPTPAVTTPTpnATSPTLgKTSPTSAVTTPTPNATSpTPAVTTPTPNATiPTLGKTSPTSAVT------TPTPNATSpT 594

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  625 VGHSTPPKRT-------------IVSPKHPEVTLPHPDQVQTQHSHLTRATVQPLDLGFTITPKSMTEVEPSTALMTTAP 691
Cdd:pfam05109  595 VGETSPQANTtnhtlggtsstpvVTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSISETLSPSTSDNSTSHMPLLTSAH 674

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  692 PPGHPEVTLPPSDKGQAQHSHLTQATVQPldleltittkPTTEVKPSPTTEETSTQPPDLGLAIIPEPTTET------GH 765
Cdd:pfam05109  675 PTGGENITQVTPASTSTHHVSTSSPAPRP----------GTTSQASGPGNSSTSTKPGEVNVTKGTPPKNATspqapsGQ 744

                          330       340       350
                   ....*....|....*....|....*....|....*..
gi 2217315144  766 STALEKTTAPRPDRVQTLHRSLTEVTGPPTELEPAQD 802
Cdd:pfam05109  745 KTAVPTVTSTGGKANSTTGGKHTTGHGARTSTEPTTD 781
ftsN TIGR02223
cell division protein FtsN; FtsN is a poorly conserved protein active in cell division in a ...
 181-414 2.65e-03

cell division protein FtsN; FtsN is a poorly conserved protein active in cell division in a number of Proteobacteria. The N-terminal 30 residue region tends to by Lys/Arg-rich, and is followed by a membrane-spanning region. This is followed by an acidic low-complexity region of variable length and a well-conserved C-terminal domain of two tandem regions matched by pfam05036 (Sporulation related repeat), found in several cell division and sporulation proteins. The role of FtsN as a suppressor for other cell division mutations is poorly understood; it may involve cell wall hydrolysis. [Cellular processes, Cell division]


Pssm-ID: 274041 [Multi-domain]  Cd Length: 298  Bit Score: 41.99  E-value: 2.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  181 QNEYSSTDTPYPgslppELRVKSDEPPGPSEQVGPSQFHLEPETQNPETLedIQSSSLQQEAPAQLPQLLEEEPSSMQQE 260
Cdd:TIGR02223    3 QRDYVRRGRGAP-----QKKKKNRRLVRATVLIAAILILLFIGGSSGLYL--LTESKQANEPETLQPKNQTENGETAADL 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  261 APAlPPESSMESLTLPNHEVSVQPPGEDQAyyhlpnitVKPADVEVTITSEPTNETESSQAQQETPIQFPEEVEPSATQQ 340
Cdd:TIGR02223   76 PPK-PEERWSYIEELEAREVLINDPEEPSN--------GGGVEESAQLTAEQRQLLEQMQADMRAAEKVLATAPSEQTVA 146

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217315144  341 EAPIEPPVPPMEHELSISEQQQ-PVQPSESPREVESSPTQQETPGQPPEHHEVTVSPpghHQTHHLASPSVSVKP 414
Cdd:TIGR02223  147 VEARKQTAEKKPQKARTAEAQKtPVETEKIASKVKEAKQKQKALPKQTAETQSNSKP---IETAPKADKADKTKP 218
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 438-785 3.41e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 42.38  E-value: 3.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  438 ATTRLSGSGNDVEPpaIQHGGPPLLPESSEEAGPLAVQQETSFQSPEPINNENPsptqqEAAAEHPQTAEEGESSLTHQE 517
Cdd:PRK10263   326 ATTATQSWAAPVEP--VTQTPPVASVDVPPAQPTVAWQPVPGPQTGEPVIAPAP-----EGYPQQSQYAQPAVQYNEPLQ 398

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  518 APAQTPEFPNVVVAQPPEHSHLTQATVQPLDLGFTITPESKTEVELSPTMKEtPTQPPKKVVPQLRVYQGVTNPTPG--Q 595
Cdd:PRK10263   399 QPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAE-EQQSTFAPQSTYQTEQTYQQPAAQepL 477

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  596 DQAQHPVSPSVTVQlldlgltitPEPTTEvghSTPPKRTivspkhPEVTLPHPDQVQTQHSHLTRATVQPLdlgftitPK 675
Cdd:PRK10263   478 YQQPQPVEQQPVVE---------PEPVVE---ETKPARP------PLYYFEEVEEKRAREREQLAAWYQPI-------PE 532

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  676 SMTEVEPSTALMTTAPPPGHPEVTlppsdkgqaqhshlTQATVQPLDLELTITTkpttevkpSPTTEETSTQPPDLGLAI 755
Cdd:PRK10263   533 PVKEPEPIKSSLKAPSVAAVPPVE--------------AAAAVSPLASGVKKAT--------LATGAAATVAAPVFSLAN 590

                          330       340       350
                   ....*....|....*....|....*....|..
gi 2217315144  756 --IPEPTTETGHSTALekttaPRPDRVQTLHR 785
Cdd:PRK10263   591 sgGPRPQVKEGIGPQL-----PRPKRIRVPTR 617
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 260-799 3.77e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.99  E-value: 3.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  260 EAPALPPESSMESLTLPNHEVSVQPPGEDqaYYHLPNitvkPADVEVTITSEPTNETESSQAQQetpiqfPEEVEPSATQ 339
Cdd:PRK10263   331 QSWAAPVEPVTQTPPVASVDVPPAQPTVA--WQPVPG----PQTGEPVIAPAPEGYPQQSQYAQ------PAVQYNEPLQ 398

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  340 QEAPIEPPVPPMEHELSISEQQQPVQPSESPREVESSPTQQETPGQPPEHHEVTVSPPGHHQTHHLASPSVSVKPPDVQl 419
Cdd:PRK10263   399 QPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQEPL- 477

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  420 tiaaepsaEVGTSLVHQEATTRLSGSGNDVEPPAiqhggPPLLP-ESSEEAGPLAVQQETSFQSPEPINNENPSPTQQEA 498
Cdd:PRK10263   478 --------YQQPQPVEQQPVVEPEPVVEETKPAR-----PPLYYfEEVEEKRAREREQLAAWYQPIPEPVKEPEPIKSSL 544

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  499 AAEHPQTAEEGESslthqeAPAQTPEFPNvvVAQPPEHSHLTQATVQP-LDLGFTITPESKTEVELSPTMKetptQPPKK 577
Cdd:PRK10263   545 KAPSVAAVPPVEA------AAAVSPLASG--VKKATLATGAAATVAAPvFSLANSGGPRPQVKEGIGPQLP----RPKRI 612

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  578 VVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQlLDLGLTITPEPTTEVGHSTPPKRTIVSPKH---PEVTLPHPDQV--- 651
Cdd:PRK10263   613 RVPTRRELASYGIKLPSQRAAEEKAREAQRNQ-YDSGDQYNDDEIDAMQQDELARQFAQTQQQrygEQYQHDVPVNAeda 691

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  652 ----------------QTQHSHLTRATVQPL---DLGFT--------------ITPKSMTEVEPSTALMTTAPPPGHPEV 698
Cdd:PRK10263   692 daaaeaelarqfaqtqQQRYSGEQPAGANPFsldDFEFSpmkallddgpheplFTPIVEPVQQPQQPVAPQQQYQQPQQP 771

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  699 TLPPSDKGQAQHSHLTQATVQPLDLELTITT---KPTTEVKPSPTTEETST--------QPPDLGLAIIPEPT------T 761
Cdd:PRK10263   772 VAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPqyqQPQQPVAPQPQYQQPQQpvapqpqyQQPQQPVAPQPQDTllhpllM 851

                          570       580       590
                   ....*....|....*....|....*....|....*...
gi 2217315144  762 ETGHSTALEKTTAPRPdrvqtlhrSLTEVTGPPTELEP 799
Cdd:PRK10263   852 RNGDSRPLHKPTTPLP--------SLDLLTPPPSEVEP 881
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 891-976 5.81e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.80  E-value: 5.81e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  891 TEKLILRENNLTELH-KDSFEGL---LSLQYLDLSCNKIQSIER------HTFEPLPFLKFINLSCNVITELSFGTFQAW 960
Cdd:cd00116     25 LQVLRLEGNTLGEEAaKALASALrpqPSLKELCLSLNETGRIPRglqsllQGLTKGCGLQELDLSDNALGPDGCGVLESL 104

                           90
                   ....*....|....*.
gi 2217315144  961 HGMQFLHKLILNHNPL 976
Cdd:cd00116    105 LRSSSLQELKLNNNGL 120
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 734-799 6.22e-03

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 36.96  E-value: 6.22e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217315144  734 EVKPSPTTEETSTQPPDLglaiipePTTETGHSTALEKTTAPRPDRVQTLHRSLTEVTGPPTELEP 799
Cdd:pfam15779    1 EVEPSPTQQETPTQPPES-------PKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLEL 59
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 174-458 6.69e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 41.44  E-value: 6.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  174 QSQKQTLQNEYSSTDTPYPGSLPPELRVKSDEPPGPSEQVGPSQFHLEPETQNPEtlediqssslqqeAPAQLPQLLEEE 253
Cdd:pfam05109  500 ESKAPDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPN-------------ATSPTPAVTTPT 566

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  254 PSSMqqeAPALPPESSMESLTLPNHEVSVQPPGEDQAYYHLPNITVKPADVEVTITSEPTNETESSQAQQEtpiQFPEEV 333
Cdd:pfam05109  567 PNAT---IPTLGKTSPTSAVTTPTPNATSPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTGQH---NITSSS 640

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  334 EPSATQQEAPIEPPVPPMEHELSISeqQQPVQPSESPREVESspTQQETPGQPPEHHEVTVSP-PGHHQTHHLASP---S 409
Cdd:pfam05109  641 TSSMSLRPSSISETLSPSTSDNSTS--HMPLLTSAHPTGGEN--ITQVTPASTSTHHVSTSSPaPRPGTTSQASGPgnsS 716

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 2217315144  410 VSVKPPDVQLTIAAEPsaevgtslvhQEATTRLSGSGNDVEPPAIQHGG 458
Cdd:pfam05109  717 TSTKPGEVNVTKGTPP----------KNATSPQAPSGQKTAVPTVTSTG 755
PHA03369 PHA03369
capsid maturational protease; Provisional
 221-392 7.17e-03

capsid maturational protease; Provisional


Pssm-ID: 223061 [Multi-domain]  Cd Length: 663  Bit Score: 41.14  E-value: 7.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  221 EPETQNPETLEDIQSSSLQQEApaqlpqlLEEEPSSMQQEAPALPPESSMESLTLPNHEVSVQPPGED-----QAYYHLP 295
Cdd:PHA03369   491 EQESLAKELEATAHKSEIKKIA-------ESEFKNAGAKTAAANIEPNCSADAAAPATKRARPETKTEleavvRFPYQIR 563

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217315144  296 NITVKPADVEVTITSEPTNETESSQAQqETPIQFPEEVEPSATQQEAPIEPPVPPMEHELSISEQ-QQPVQPSESPREVE 374
Cdd:PHA03369   564 NMESPAFVHSFTSTTLAAAAGQGSDTA-EALAGAIETLLTQASAQPAGLSLPAPAVPVNASTPAStPPPLAPQEPPQPGT 642

                          170
                   ....*....|....*...
gi 2217315144  375 SSPTqqeTPGQPPEHHEV 392
Cdd:PHA03369   643 SAPS---LETSLPQQKPV 657
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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