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Conserved domains on  [gi|2217311057|ref|XP_047291687|]
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protein TANC2 isoform X8 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1063-1262 6.42e-52

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 185.54  E-value: 6.42e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1063 INSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLM 1142
Cdd:COG0666     46 ALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLH 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1143 MAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFL 1222
Cdd:COG0666    126 LAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLL 205

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 2217311057 1223 VDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1262
Cdd:COG0666    206 LEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL 245
PHA03095 super family cl33707
ankyrin-like protein; Provisional
 893-1187 7.18e-19

ankyrin-like protein; Provisional


The actual alignment was detected with superfamily member PHA03095:

Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 92.01  E-value: 7.18e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057  893 RNLYTPNIKVS--RLLILGGANINYRTEvLNNAPiLCVQSHLG---YTEMVALLLEFGANVDASSESGLTPLG-YAAAAG 966
Cdd:PHA03095    18 YLLNASNVTVEevRRLLAAGADVNFRGE-YGKTP-LHLYLHYSsekVKDIVRLLLEAGADVNAPERCGFTPLHlYLYNAT 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057  967 YLSIVVLLCKKRAKVDHLDKNGQCALvHAALRG---HLEVVKFLIQ-----CDWTMAGQQQ-GVFKKSHAIQQaliaaas 1037
Cdd:PHA03095    96 TLDVIKLLIKAGADVNAKDKVGRTPL-HVYLSGfniNPKVIRLLLRkgadvNALDLYGMTPlAVLLKSRNANV------- 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1038 mgytEIVSYLLDlpeKDEEEVERAqiNSFDSLWGETALTAaagRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHW 1117
Cdd:PHA03095   168 ----ELLRLLID---AGADVYAVD--DRFRSLLHHHLQSF---KPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSC 235

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217311057 1118 Q--IVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVR 1187
Cdd:PHA03095   236 KrsLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVR 307
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1298-1412 4.76e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 71.19  E-value: 4.76e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1298 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1377
Cdd:COG0457     15 GLAYRRLGRYEEAIEDYEKALELDPDD-------------AEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2217311057 1378 RARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLL 1412
Cdd:COG0457     82 LGLALQALGRYEEALEDYDKALELDPDDAEALYNL 116
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 1474-1703 4.19e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 4.19e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1474 LQTEARPSQGLPVIQSP-PSSPPHRDSAYISSSPLGShqvfdfrsSSSVGSPTRQTYQSTSPALSPTHqnshyRPSPPht 1552
Cdd:PHA03247  2818 LPPAASPAGPLPPPTSAqPTAPPPPPGPPPPSLPLGG--------SVAPGGDVRRRPPSRSPAAKPAA-----PARPP-- 2882

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1553 spahqggSYRFSPPPVGGQGKEYPSPPpSPLRRGPQYRASPPAesmsvyRSQSGSPVRyQQETSVSQLPGRPKSPLSKMA 1632
Cdd:PHA03247  2883 -------VRRLARPAVSRSTESFALPP-DQPERPPQPQAPPPP------QPQPQPPPP-PQPQPPPPPPPRPQPPLAPTT 2947

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1633 Q-RPYQMPQLPVAVPQQGlRLQPAKAQIVRSNQPSPA---------VHSSTVIPTGAYGQVAHSMASKYQSSQGDIGVSQ 1702
Cdd:PHA03247  2948 DpAGAGEPSGAVPQPWLG-ALVPGRVAVPRFRVPQPApsreapassTPPLTGHSLSRVSSWASSLALHEETDPPPVSLKQ 3026


                   .
gi 2217311057 1703 S 1703
Cdd:PHA03247  3027 T 3027
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1063-1262 6.42e-52

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 185.54  E-value: 6.42e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1063 INSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLM 1142
Cdd:COG0666     46 ALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLH 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1143 MAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFL 1222
Cdd:COG0666    126 LAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLL 205

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 2217311057 1223 VDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1262
Cdd:COG0666    206 LEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL 245
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1141-1227 7.85e-21

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 88.63  E-value: 7.85e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1141 LMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDhaDKNGRTPLDLAAFYGDAEVVQ 1220
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL--KDNGRTALHYAARSGHLEIVK 78


                   ....*..
gi 2217311057 1221 FLVDHGA 1227
Cdd:pfam12796   79 LLLEKGA 85
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1046-1266 5.16e-19

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 92.78  E-value: 5.16e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1046 YLLDLPEKDEEEVER-----AQINsFDSLWGETALTAAAGRGK---LEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGH- 1116
Cdd:PHA03095    18 YLLNASNVTVEEVRRllaagADVN-FRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATt 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1117 WQIVDLLLTHGADVNMADKQGRTPLMMAAS--EGHLGTVDFLLAQGASIALMDKEGLTALswACL--------------- 1179
Cdd:PHA03095    97 LDVIKLLIKAGADVNAKDKVGRTPLHVYLSgfNINPKVIRLLLRKGADVNALDLYGMTPL--AVLlksrnanvellrlli 174

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1180 -KG----------------HL-------SVVRSLVDNGAATDHADKNGRTPLDLAAFYGD--AEVVQFLVDHGAMIEHVD 1233
Cdd:PHA03095   175 dAGadvyavddrfrsllhhHLqsfkpraRIVRELIRAGCDPAATDMLGNTPLHSMATGSSckRSLVLPLLIAGISINARN 254

                          250       260       270
                   ....*....|....*....|....*....|...
gi 2217311057 1234 YSGMRPLDRAVGCRNTSVVVTLLKKGAKIGCQT 1266
Cdd:PHA03095   255 RYGQTPLHYAAVFNNPRACRRLIALGADINAVS 287
PHA03095 PHA03095
ankyrin-like protein; Provisional
 893-1187 7.18e-19

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 92.01  E-value: 7.18e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057  893 RNLYTPNIKVS--RLLILGGANINYRTEvLNNAPiLCVQSHLG---YTEMVALLLEFGANVDASSESGLTPLG-YAAAAG 966
Cdd:PHA03095    18 YLLNASNVTVEevRRLLAAGADVNFRGE-YGKTP-LHLYLHYSsekVKDIVRLLLEAGADVNAPERCGFTPLHlYLYNAT 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057  967 YLSIVVLLCKKRAKVDHLDKNGQCALvHAALRG---HLEVVKFLIQ-----CDWTMAGQQQ-GVFKKSHAIQQaliaaas 1037
Cdd:PHA03095    96 TLDVIKLLIKAGADVNAKDKVGRTPL-HVYLSGfniNPKVIRLLLRkgadvNALDLYGMTPlAVLLKSRNANV------- 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1038 mgytEIVSYLLDlpeKDEEEVERAqiNSFDSLWGETALTAaagRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHW 1117
Cdd:PHA03095   168 ----ELLRLLID---AGADVYAVD--DRFRSLLHHHLQSF---KPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSC 235

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217311057 1118 Q--IVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVR 1187
Cdd:PHA03095   236 KrsLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVR 307
Ank_2 pfam12796
Ankyrin repeats (3 copies);
933-1011 3.06e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.14  E-value: 3.06e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217311057  933 GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKrAKVDHLDkNGQCALVHAALRGHLEVVKFLIQCD 1011
Cdd:pfam12796    8 GNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLLLEKG 84
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1298-1412 4.76e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 71.19  E-value: 4.76e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1298 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1377
Cdd:COG0457     15 GLAYRRLGRYEEAIEDYEKALELDPDD-------------AEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2217311057 1378 RARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLL 1412
Cdd:COG0457     82 LGLALQALGRYEEALEDYDKALELDPDDAEALYNL 116
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 957-1223 3.61e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.94  E-value: 3.61e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057  957 TPLGYAAAAGYL-SIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQqqgvfkkshaiqqaliaa 1035
Cdd:cd22192     19 SPLLLAAKENDVqAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPELVNE------------------ 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1036 asmgytEIVSyllDLPEkdeeeveraqinsfdslwGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAV--------- 1106
Cdd:cd22192     81 ------PMTS---DLYQ------------------GETALHIAVVNQNLNLVRELIARGADVVSPRATGTFfrpgpknli 133

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1107 -----PLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTV----DFLLAqgasialMDKEgltalswa 1177
Cdd:cd22192    134 yygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFAcqmyDLILS-------YDKE-------- 198

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 2217311057 1178 clkghlsvvrslvDNGAATDH-ADKNGRTPLDLAAFYGDAEVVQFLV 1223
Cdd:cd22192    199 -------------DDLQPLDLvPNNQGLTPFKLAAKEGNIVMFQHLV 232
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 1299-1414 4.75e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.54  E-value: 4.75e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1299 DMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYAR 1378
Cdd:TIGR02917  507 RIDIQEGNPDDAIQRFEKVLTIDPKN-------------LRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALAL 573

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2217311057 1379 ARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLR 1414
Cdd:TIGR02917  574 AQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGR 609
TPR_14 pfam13428
Tetratricopeptide repeat;
1373-1415 1.39e-04

Tetratricopeptide repeat;


Pssm-ID: 463874 [Multi-domain]  Cd Length: 44  Bit Score: 41.25  E-value: 1.39e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2217311057 1373 EAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLRV 1415
Cdd:pfam13428    2 EALLALARALLALGDPDEALALLERALALDPDDPEAWLALAQL 44
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1202-1230 1.43e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.65  E-value: 1.43e-04
                            10        20
                    ....*....|....*....|....*....
gi 2217311057  1202 NGRTPLDLAAFYGDAEVVQFLVDHGAMIE 1230
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 1053-1230 3.77e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 45.46  E-value: 3.77e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1053 KDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQgaavaqpNRRGAV--PLFSTVRQGHWQIVDLLLTHGADV 1130
Cdd:TIGR00870   35 RDLEEPKKLNINCPDRLGRSALFVAAIENENLELTELLLNL-------SCRGAVgdTLLHAISLEYVDAVEAILLHLLAA 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1131 nmADKQGRTPLMMAASeghlgTVDFllaqgasialmdKEGLTALSWACLKGHLSVVRSLVDNGAA------------TDH 1198
Cdd:TIGR00870  108 --FRKSGPLELANDQY-----TSEF------------TPGITALHLAAHRQNYEIVKLLLERGASvparacgdffvkSQG 168

                          170       180       190
                   ....*....|....*....|....*....|....
gi 2217311057 1199 AD--KNGRTPLDLAAFYGDAEVVQFLVDHGAMIE 1230
Cdd:TIGR00870  169 VDsfYHGESPLNAAACLGSPSIVALLSEDPADIL 202
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1474-1703 4.19e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 4.19e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1474 LQTEARPSQGLPVIQSP-PSSPPHRDSAYISSSPLGShqvfdfrsSSSVGSPTRQTYQSTSPALSPTHqnshyRPSPPht 1552
Cdd:PHA03247  2818 LPPAASPAGPLPPPTSAqPTAPPPPPGPPPPSLPLGG--------SVAPGGDVRRRPPSRSPAAKPAA-----PARPP-- 2882

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1553 spahqggSYRFSPPPVGGQGKEYPSPPpSPLRRGPQYRASPPAesmsvyRSQSGSPVRyQQETSVSQLPGRPKSPLSKMA 1632
Cdd:PHA03247  2883 -------VRRLARPAVSRSTESFALPP-DQPERPPQPQAPPPP------QPQPQPPPP-PQPQPPPPPPPRPQPPLAPTT 2947

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1633 Q-RPYQMPQLPVAVPQQGlRLQPAKAQIVRSNQPSPA---------VHSSTVIPTGAYGQVAHSMASKYQSSQGDIGVSQ 1702
Cdd:PHA03247  2948 DpAGAGEPSGAVPQPWLG-ALVPGRVAVPRFRVPQPApsreapassTPPLTGHSLSRVSSWASSLALHEETDPPPVSLKQ 3026


                   .
gi 2217311057 1703 S 1703
Cdd:PHA03247  3027 T 3027
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1484-1676 1.72e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.60  E-value: 1.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1484 LPVIQSPPSSP-PHRDSAYISSSPLGSHQVFDFRSSSSVGSPtrqtyqstsPALSPTHQNSHYRPSPPHtspahqggsyr 1562
Cdd:pfam03154  352 MPHIKPPPTTPiPQLPNPQSHKHPPHLSGPSPFQMNSNLPPP---------PALKPLSSLSTHHPPSAH----------- 411

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1563 fsPPPVggqgkeypspppsPLRRGPQYRASPPAESMSVYRSQSGSPVRYQQETSVSQLPGRPKSPLSKMAQRPYQMPQL- 1641
Cdd:pfam03154  412 --PPPL-------------QLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPIt 476

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 2217311057 1642 -----PVAVPQQGLRLQPAKAQIVRSNQPSPAVHSSTVIP 1676
Cdd:pfam03154  477 ppsgpPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPP 516
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 1352-1403 2.20e-03

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 42.47  E-value: 2.20e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2217311057 1352 NDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCP 1403
Cdd:PLN03088    16 DDFALAVDLYTQAIDLDPNNAELYADRAQANIKLGNFTEAVADANKAIELDP 67
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 1372-1405 5.42e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 36.27  E-value: 5.42e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 2217311057  1372 YEAYYARARAKRSSRQFAAALEDLNEAIKLCPNN 1405
Cdd:smart00028    1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1063-1262 6.42e-52

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 185.54  E-value: 6.42e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1063 INSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLM 1142
Cdd:COG0666     46 ALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLH 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1143 MAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFL 1222
Cdd:COG0666    126 LAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLL 205

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 2217311057 1223 VDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1262
Cdd:COG0666    206 LEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL 245
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1071-1262 7.03e-51

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 182.46  E-value: 7.03e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1071 GETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHL 1150
Cdd:COG0666     87 GNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNL 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1151 GTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIE 1230
Cdd:COG0666    167 EIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLN 246

                          170       180       190
                   ....*....|....*....|....*....|..
gi 2217311057 1231 HVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1262
Cdd:COG0666    247 AKDKDGLTALLLAAAAGAALIVKLLLLALLLL 278
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
905-1240 1.19e-46

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 170.13  E-value: 1.19e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057  905 LLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHL 984
Cdd:COG0666      4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057  985 DKNGQCALVHAALRGHLEVVKFLIQcdwtmAGqqqgvfkkshaiqqaliaaasmgyteivsylldlpekdeeeverAQIN 1064
Cdd:COG0666     84 DDGGNTLLHAAARNGDLEIVKLLLE-----AG--------------------------------------------ADVN 114

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1065 SFDSlWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMA 1144
Cdd:COG0666    115 ARDK-DGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLA 193

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1145 ASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVD 1224
Cdd:COG0666    194 AENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLL 273

                          330
                   ....*....|....*.
gi 2217311057 1225 HGAMIEHVDYSGMRPL 1240
Cdd:COG0666    274 ALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
888-1207 2.36e-44

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 163.59  E-value: 2.36e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057  888 ALASLRNLYTPNIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGY 967
Cdd:COG0666     20 LLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGD 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057  968 LSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQcdwtmAGqqqgvfkkshaiqqaliaaasmgyteivsyl 1047
Cdd:COG0666    100 LEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLE-----AG------------------------------- 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1048 ldlpekdeeeverAQINSFDSlWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHG 1127
Cdd:COG0666    144 -------------ADVNAQDN-DGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAG 209

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1128 ADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPL 1207
Cdd:COG0666    210 ADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1141-1227 7.85e-21

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 88.63  E-value: 7.85e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1141 LMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDhaDKNGRTPLDLAAFYGDAEVVQ 1220
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL--KDNGRTALHYAARSGHLEIVK 78


                   ....*..
gi 2217311057 1221 FLVDHGA 1227
Cdd:pfam12796   79 LLLEKGA 85
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1046-1266 5.16e-19

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 92.78  E-value: 5.16e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1046 YLLDLPEKDEEEVER-----AQINsFDSLWGETALTAAAGRGK---LEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGH- 1116
Cdd:PHA03095    18 YLLNASNVTVEEVRRllaagADVN-FRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATt 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1117 WQIVDLLLTHGADVNMADKQGRTPLMMAAS--EGHLGTVDFLLAQGASIALMDKEGLTALswACL--------------- 1179
Cdd:PHA03095    97 LDVIKLLIKAGADVNAKDKVGRTPLHVYLSgfNINPKVIRLLLRKGADVNALDLYGMTPL--AVLlksrnanvellrlli 174

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1180 -KG----------------HL-------SVVRSLVDNGAATDHADKNGRTPLDLAAFYGD--AEVVQFLVDHGAMIEHVD 1233
Cdd:PHA03095   175 dAGadvyavddrfrsllhhHLqsfkpraRIVRELIRAGCDPAATDMLGNTPLHSMATGSSckRSLVLPLLIAGISINARN 254

                          250       260       270
                   ....*....|....*....|....*....|...
gi 2217311057 1234 YSGMRPLDRAVGCRNTSVVVTLLKKGAKIGCQT 1266
Cdd:PHA03095   255 RYGQTPLHYAAVFNNPRACRRLIALGADINAVS 287
PHA03095 PHA03095
ankyrin-like protein; Provisional
 893-1187 7.18e-19

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 92.01  E-value: 7.18e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057  893 RNLYTPNIKVS--RLLILGGANINYRTEvLNNAPiLCVQSHLG---YTEMVALLLEFGANVDASSESGLTPLG-YAAAAG 966
Cdd:PHA03095    18 YLLNASNVTVEevRRLLAAGADVNFRGE-YGKTP-LHLYLHYSsekVKDIVRLLLEAGADVNAPERCGFTPLHlYLYNAT 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057  967 YLSIVVLLCKKRAKVDHLDKNGQCALvHAALRG---HLEVVKFLIQ-----CDWTMAGQQQ-GVFKKSHAIQQaliaaas 1037
Cdd:PHA03095    96 TLDVIKLLIKAGADVNAKDKVGRTPL-HVYLSGfniNPKVIRLLLRkgadvNALDLYGMTPlAVLLKSRNANV------- 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1038 mgytEIVSYLLDlpeKDEEEVERAqiNSFDSLWGETALTAaagRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHW 1117
Cdd:PHA03095   168 ----ELLRLLID---AGADVYAVD--DRFRSLLHHHLQSF---KPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSC 235

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217311057 1118 Q--IVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVR 1187
Cdd:PHA03095   236 KrsLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVR 307
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1112-1194 2.05e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 81.70  E-value: 2.05e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1112 VRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGAsiALMDKEGLTALSWACLKGHLSVVRSLVD 1191
Cdd:pfam12796    5 AKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAARSGHLEIVKLLLE 82


                   ...
gi 2217311057 1192 NGA 1194
Cdd:pfam12796   83 KGA 85
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 948-1243 1.68e-17

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 87.71  E-value: 1.68e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057  948 VDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQcdwtmagqqQGVfkksha 1027
Cdd:PHA02874    28 INISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLID---------NGV------ 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1028 iqqaliaaasmgyteiVSYLLDLPEKDEEEVER-----AQINSFDSLwGETALTAAAGRGKLEVCRLLLEQGAAVAQPNR 1102
Cdd:PHA02874    93 ----------------DTSILPIPCIEKDMIKTildcgIDVNIKDAE-LKTFLHYAIKKGDLESIKMLFEYGADVNIEDD 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1103 RGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGH 1182
Cdd:PHA02874   156 NGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNR 235

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217311057 1183 lSVVRSLVDNGAATDhADKNGRTPLDLAAFYG-DAEVVQFLVDHGAMIEHVDYSGMRPLDRA 1243
Cdd:PHA02874   236 -SAIELLINNASIND-QDIDGSTPLHHAINPPcDIDIIDILLYHKADISIKDNKGENPIDTA 295
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1075-1167 9.23e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.08  E-value: 9.23e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1075 LTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHgADVNMADkQGRTPLMMAASEGHLGTVD 1154
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 2217311057 1155 FLLAQGASIALMD 1167
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 936-1202 2.69e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 83.56  E-value: 2.69e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057  936 EMVALLLEFGANVDASSESGLTPLGYAAAAGY-----LSIVVLLCKKRAKVDHLDKNGQCALVHAALRghlevvkfliqc 1010
Cdd:PHA03100    49 DVVKILLDNGADINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDNNGITPLLYAISK------------ 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1011 dwtmagqqqgvfkkshaiqqaliaaaSMGYTEIVSYLLDLpekdeeeveRAQINSFDSlWGETALTAAA--GRGKLEVCR 1088
Cdd:PHA03100   117 --------------------------KSNSYSIVEYLLDN---------GANVNIKNS-DGENLLHLYLesNKIDLKILK 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1089 LLLEQGAAVAQPNRrgavplfstvrqghwqiVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDK 1168
Cdd:PHA03100   161 LLIDKGVDINAKNR-----------------VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNK 223

                          250       260       270
                   ....*....|....*....|....*....|....
gi 2217311057 1169 EGLTALSWACLKGHLSVVRSLVDNGAATDHADKN 1202
Cdd:PHA03100   224 YGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIET 257
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 900-1262 2.86e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 85.12  E-value: 2.86e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057  900 IKVSRLLILGGANINYRtEVLNNAPILCVQSHlGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRA 979
Cdd:PHA02876   158 LLIAEMLLEGGADVNAK-DIYCITPIHYAAER-GNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRS 235

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057  980 KVDHLDkngqCALVHAALRGHLEVVKFLIQCDWTMagQQQGVFKKSHAIQQALIAAASmgytEIVSYLLdlpekdeeevE 1059
Cdd:PHA02876   236 NINKND----LSLLKAIRNEDLETSLLLYDAGFSV--NSIDDCKNTPLHHASQAPSLS----RLVPKLL----------E 295

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1060 RAQINSFDSLWGETALTAAAGRG-KLEVCRLLLEQGAAVAQPNRRGAVPLF-STVRQGHWQIVDLLLTHGADVNMADKQG 1137
Cdd:PHA02876   296 RGADVNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLYITPLHqASTLDRNKDIVITLLELGANVNARDYCD 375

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1138 RTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWA-CLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYG-D 1215
Cdd:PHA02876   376 KTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFAlCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNcK 455

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*..
gi 2217311057 1216 AEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRntSVVVTLLKKGAKI 1262
Cdd:PHA02876   456 LDVIEMLLDNGADVNAINIQNQYPLLIALEYH--GIVNILLHYGAEL 500
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1072-1293 2.99e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 83.50  E-value: 2.99e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1072 ETALTAAAGRGKLEVCRLLLEQGAavaQPN---RRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEG 1148
Cdd:PHA02875     3 QVALCDAILFGELDIARRLLDIGI---NPNfeiYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEG 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1149 HLGTVDFLLAQGASIA-LMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGA 1227
Cdd:PHA02875    80 DVKAVEELLDLGKFADdVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKA 159

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217311057 1228 MIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI------GCQTLpsrprgpATWAMATSKPDIMIILLSK 1293
Cdd:PHA02875   160 CLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIdyfgknGCVAA-------LCYAIENNKIDIVRLFIKR 224
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1174-1265 3.43e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 75.54  E-value: 3.43e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1174 LSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHgAMIEHVDYsGMRPLDRAVGCRNTSVVV 1253
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHLEIVK 78

                           90
                   ....*....|..
gi 2217311057 1254 TLLKKGAKIGCQ 1265
Cdd:pfam12796   79 LLLEKGADINVK 90
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1083-1262 3.75e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 83.18  E-value: 3.75e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1083 KLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQ-----IVDLLLTHGADVNMADKQGRTPLMMAASE--GHLGTVDF 1155
Cdd:PHA03100    47 NIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLtdvkeIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEY 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1156 LLAQGASIALMDKEGLTALSWA--CLKGHLSVVRSLVDNGA----------------ATDHADKNGRTPLDLAAFYGDAE 1217
Cdd:PHA03100   127 LLDNGANVNIKNSDGENLLHLYleSNKIDLKILKLLIDKGVdinaknrvnyllsygvPINIKDVYGFTPLHYAVYNNNPE 206

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 2217311057 1218 VVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1262
Cdd:PHA03100   207 FVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSI 251
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1073-1256 1.53e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 81.55  E-value: 1.53e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1073 TALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGAD----------------------- 1129
Cdd:PHA02874    37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDtsilpipciekdmiktildcgid 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1130 VNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDL 1209
Cdd:PHA02874   117 VNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHN 196

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 2217311057 1210 AAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVgCRNTSVVVTLL 1256
Cdd:PHA02874   197 AAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAI-IHNRSAIELLI 242
Ank_2 pfam12796
Ankyrin repeats (3 copies);
933-1011 3.06e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.14  E-value: 3.06e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217311057  933 GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKrAKVDHLDkNGQCALVHAALRGHLEVVKFLIQCD 1011
Cdd:pfam12796    8 GNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLLLEKG 84
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1118-1262 1.67e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 75.30  E-value: 1.67e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1118 QIVDLLLTHGADVNMADK-QGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAAT 1196
Cdd:PHA02878   148 EITKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGAST 227

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217311057 1197 DHADKNGRTPLDLAAFY-GDAEVVQFLVDHGAMIEHVDY-SGMRPLDRAVgcRNTSVVVTLLKKGAKI 1262
Cdd:PHA02878   228 DARDKCGNTPLHISVGYcKDYDILKLLLEHGVDVNAKSYiLGLTALHSSI--KSERKLKLLLEYGADI 293
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1298-1412 4.76e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 71.19  E-value: 4.76e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1298 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1377
Cdd:COG0457     15 GLAYRRLGRYEEAIEDYEKALELDPDD-------------AEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2217311057 1378 RARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLL 1412
Cdd:COG0457     82 LGLALQALGRYEEALEDYDKALELDPDDAEALYNL 116
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1039-1260 8.74e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 72.72  E-value: 8.74e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1039 GYTEIVSYLLDLpekdeeeveraQIN-SFDSLWGETALTAAAGRGKLEVCRLLLEQGAA--VAQPNRRGavPLFSTVRQG 1115
Cdd:PHA02875    13 GELDIARRLLDI-----------GINpNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIpdVKYPDIES--ELHDAVEEG 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1116 HWQIVDLLLTHGADVN-MADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGA 1194
Cdd:PHA02875    80 DVKAVEELLDLGKFADdVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKA 159

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1195 ATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAmieHVDYSGMRP----LDRAVGCRNTSVVVTLLKKGA 1260
Cdd:PHA02875   160 CLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGA---NIDYFGKNGcvaaLCYAIENNKIDIVRLFIKRGA 226
Ank_2 pfam12796
Ankyrin repeats (3 copies);
959-1095 2.46e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 64.75  E-value: 2.46e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057  959 LGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIqcdwtmagqqqgvfkkshaiqqaliaaasm 1038
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL------------------------------ 50

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217311057 1039 gyteivsylldlpekdeeevERAQINSFDSlwGETALTAAAGRGKLEVCRLLLEQGA 1095
Cdd:pfam12796   51 --------------------EHADVNLKDN--GRTALHYAARSGHLEIVKLLLEKGA 85
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1298-1412 2.96e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.88  E-value: 2.96e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1298 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1377
Cdd:COG0457     49 GLAYLRLGRYEEALADYEQALELDPDD-------------AEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYN 115

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2217311057 1378 RARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLL 1412
Cdd:COG0457    116 LGLALLELGRYDEAIEAYERALELDPDDADALYNL 150
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1084-1233 5.25e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 70.08  E-value: 5.25e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1084 LEVCRLLLEQGAAVAQPNRRGAVPLF--STVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGT--------- 1152
Cdd:PHA03100    86 KEIVKLLLEYGANVNAPDNNGITPLLyaISKKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLkilkllidk 165

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1153 ---------VDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLV 1223
Cdd:PHA03100   166 gvdinaknrVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLL 245

                          170
                   ....*....|
gi 2217311057 1224 DHGAMIEHVD 1233
Cdd:PHA03100   246 NNGPSIKTII 255
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1298-1405 7.25e-12

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 64.83  E-value: 7.25e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1298 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1377
Cdd:COG4783     45 GEILLQLGDLDEAIVLLHEALELDPDE-------------PEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLR 111

                           90       100
                   ....*....|....*....|....*...
gi 2217311057 1378 RARAKRSSRQFAAALEDLNEAIKLCPNN 1405
Cdd:COG4783    112 LARAYRALGRPDEAIAALEKALELDPDD 139
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1084-1267 1.06e-11

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 70.28  E-value: 1.06e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1084 LEVCRLLLEQGAAVAQPNRrgAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASI 1163
Cdd:PLN03192   507 LNVGDLLGDNGGEHDDPNM--ASNLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNV 584

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1164 ALMDKEGLTALSWACLKGHLSVVRSLVDNGAATD-HAdknGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDR 1242
Cdd:PLN03192   585 HIRDANGNTALWNAISAKHHKIFRILYHFASISDpHA---AGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQV 661

                          170       180
                   ....*....|....*....|....*
gi 2217311057 1243 AVGCRNTSVVVTLLKKGAKIGCQTL 1267
Cdd:PLN03192   662 AMAEDHVDMVRLLIMNGADVDKANT 686
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
1301-1407 1.11e-11

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 62.88  E-value: 1.11e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1301 FYKKGKVKEAAQRYQYALKKFPREGfgedlktfrelkvSLLLNLSRCRRKMNDFGMAEEFaTKALELKPKSYEAYYARAR 1380
Cdd:COG3063      2 YLKLGDLEEAEEYYEKALELDPDNA-------------DALNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNLAE 67

                           90       100
                   ....*....|....*....|....*..
gi 2217311057 1381 AKRSSRQFAAALEDLNEAIKLCPNNRE 1407
Cdd:COG3063     68 LLLELGDYDEALAYLERALELDPSALR 94
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1298-1414 1.45e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 69.64  E-value: 1.45e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1298 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1377
Cdd:COG3914    119 GNLLLALGRLEEALAALRRALALNPDF-------------AEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNN 185

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 2217311057 1378 RARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLR 1414
Cdd:COG3914    186 LGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLF 222
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1291-1418 1.47e-11

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 64.06  E-value: 1.47e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1291 LSKLMEEGDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPK 1370
Cdd:COG4783      4 AEALYALAQALLLAGDYDEAEALLEKALELDPDN-------------PEAFALLGEILLQLGDLDEAIVLLHEALELDPD 70

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 2217311057 1371 SYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLRVEEE 1418
Cdd:COG4783     71 EPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRA 118
Ank_4 pfam13637
Ankyrin repeats (many copies);
1170-1223 2.01e-11

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 60.75  E-value: 2.01e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2217311057 1170 GLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLV 1223
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1294-1418 3.71e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 65.91  E-value: 3.71e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1294 LMEEGDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYE 1373
Cdd:COG2956     79 LLELAQDYLKAGLLDRAEELLEKLLELDPDD-------------AEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAH 145

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 2217311057 1374 AYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLRVEEE 1418
Cdd:COG2956    146 AYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLE 190
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1301-1412 4.29e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 68.10  E-value: 4.29e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1301 FYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARAR 1380
Cdd:COG3914     88 LQALGRYEEALALYRRALALNPDN-------------AEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGE 154

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2217311057 1381 AKRSSRQFAAALEDLNEAIKLCPNNREIQRLL 1412
Cdd:COG3914    155 ALRRLGRLEEAIAALRRALELDPDNAEALNNL 186
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1112-1267 1.35e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 66.63  E-value: 1.35e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1112 VRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVD 1191
Cdd:PHA02876   153 IQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIID 232

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217311057 1192 NGAatdHADKNGRTPLDlAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTS-VVVTLLKKGAKIGCQTL 1267
Cdd:PHA02876   233 NRS---NINKNDLSLLK-AIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLSrLVPKLLERGADVNAKNI 305
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 1298-1417 1.95e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 60.40  E-value: 1.95e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1298 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1377
Cdd:COG4235     24 GRAYLRLGRYDEALAAYEKALRLDPDN-------------ADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYL 90

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 2217311057 1378 RARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLRVEE 1417
Cdd:COG4235     91 LGLAAFQQGDYAEAIAAWQKLLALLPADAPARLLEASIAE 130
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 1309-1412 2.13e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 60.40  E-value: 2.13e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1309 EAAQRYQYALKKFPREGFGedlktfrelkvslLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQF 1388
Cdd:COG4235      1 EAIARLRQALAANPNDAEG-------------WLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDT 67

                           90       100
                   ....*....|....*....|....
gi 2217311057 1389 AAALEDLNEAIKLCPNNREIQRLL 1412
Cdd:COG4235     68 EEAEELLERALALDPDNPEALYLL 91
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 901-1233 4.58e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 64.21  E-value: 4.58e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057  901 KVSRLLILGGANinyrTEVLnnaPILCVQShlgytEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAK 980
Cdd:PHA02874    82 DIIKLLIDNGVD----TSIL---PIPCIEK-----DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGAD 149

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057  981 VDHLDKNGqCALVHAALRGhlevvkfliqcdwtmagqqqgvfkkshaiqqaliaaasmgyteivsylldlpekdeeever 1060
Cdd:PHA02874   150 VNIEDDNG-CYPIHIAIKH------------------------------------------------------------- 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1061 aqiNSFDslwgetaltaaagrgkleVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTP 1140
Cdd:PHA02874   168 ---NFFD------------------IIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTP 226

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1141 LMMAASegHLGTVDFLLAQGASIALMDKEGLTALSWA----CLKghlSVVRSLVDNGAATDHADKNGRTPLDLAAFY-GD 1215
Cdd:PHA02874   227 LHNAII--HNRSAIELLINNASINDQDIDGSTPLHHAinppCDI---DIIDILLYHKADISIKDNKGENPIDTAFKYiNK 301

                          330
                   ....*....|....*...
gi 2217311057 1216 AEVVQFLVDHGAMIEHVD 1233
Cdd:PHA02874   302 DPVIKDIIANAVLIKEAD 319
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 1309-1415 6.07e-10

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 59.97  E-value: 6.07e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1309 EAAQRYQYALKKFPREGFGEDLKTFRELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQF 1388
Cdd:COG5010     25 EKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDK 104

                           90       100
                   ....*....|....*....|....*..
gi 2217311057 1389 AAALEDLNEAIKLCPNNREIQRLLLRV 1415
Cdd:COG5010    105 DEAKEYYEKALALSPDNPNAYSNLAAL 131
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1341-1405 1.13e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 61.18  E-value: 1.13e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217311057 1341 LLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNN 1405
Cdd:COG0457     11 YNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDD 75
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 897-1136 1.66e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 62.38  E-value: 1.66e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057  897 TPNIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGY--LSIVVLL 974
Cdd:PHA03100    83 TDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLL 162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057  975 CKKRAKVDHLDKngqcalvhaalrghlevVKFLIqcdwtmagqqqgvfkkshaiqqaliaaasmgyteivSYLLDLPEKD 1054
Cdd:PHA03100   163 IDKGVDINAKNR-----------------VNYLL------------------------------------SYGVPINIKD 189

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1055 EeeveraqinsfdslWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMAD 1134
Cdd:PHA03100   190 V--------------YGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTII 255


                   ..
gi 2217311057 1135 KQ 1136
Cdd:PHA03100   256 ET 257
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 1300-1403 1.76e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 58.43  E-value: 1.76e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1300 MFYKKGKVKEAAQRYQYALKKFPREGfgedlktfrelkvSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARA 1379
Cdd:COG5010     63 LYNKLGDFEESLALLEQALQLDPNNP-------------ELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLA 129

                           90       100
                   ....*....|....*....|....
gi 2217311057 1380 RAKRSSRQFAAALEDLNEAIKLCP 1403
Cdd:COG5010    130 ALLLSLGQDDEAKAALQRALGTSP 153
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1083-1262 3.86e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 62.00  E-value: 3.86e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1083 KLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVD-------- 1154
Cdd:PHA02876   157 ELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKaiidnrsn 236

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1155 ---------------------FLLAQGASIALMDKEGLTALSWACLKGHLS-VVRSLVDNGAATDHADKNGRTPLDLAAF 1212
Cdd:PHA02876   237 inkndlsllkairnedletslLLYDAGFSVNSIDDCKNTPLHHASQAPSLSrLVPKLLERGADVNAKNIKGETPLYLMAK 316

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2217311057 1213 YG-DAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGC-RNTSVVVTLLKKGAKI 1262
Cdd:PHA02876   317 NGyDTENIRTLIMLGADVNAADRLYITPLHQASTLdRNKDIVITLLELGANV 368
PHA02798 PHA02798
ankyrin-like protein; Provisional
 1083-1235 4.41e-09

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 61.39  E-value: 4.41e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1083 KLEVCRLLLEQGAAVAQPNRRGAVPLFSTVR-----QGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLL 1157
Cdd:PHA02798    50 STDIVKLFINLGANVNGLDNEYSTPLCTILSnikdyKHMLDIVKILIENGADINKKNSDGETPLYCLLSNGYINNLEILL 129

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1158 ---AQGASIALMDKEGLTALSWACLKGH---LSVVRSLVDNGAATD-HADKNGRTPLDLAAFYG----DAEVVQFLVDHG 1226
Cdd:PHA02798   130 fmiENGADTTLLDKDGFTMLQVYLQSNHhidIEIIKLLLEKGVDINtHNNKEKYDTLHCYFKYNidriDADILKLFVDNG 209


                   ....*....
gi 2217311057 1227 AMIEHVDYS 1235
Cdd:PHA02798   210 FIINKENKS 218
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1143-1225 4.84e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 61.45  E-value: 4.84e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1143 MAASEGHLGtVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFL 1222
Cdd:PTZ00322    89 LAASGDAVG-ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167


                   ...
gi 2217311057 1223 VDH 1225
Cdd:PTZ00322   168 SRH 170
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1298-1465 8.51e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 58.48  E-value: 8.51e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1298 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1377
Cdd:COG0457     83 GLALQALGRYEEALEDYDKALELDPDD-------------AEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYN 149

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1378 RARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLRVEEECRQMQQPQQPPPPPQPQQQLPEEAEPEPQHEDIYSVQDI 1457
Cdd:COG0457    150 LGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALAL 229


                   ....*...
gi 2217311057 1458 FEEEYLEQ 1465
Cdd:COG0457    230 LLALRLAA 237
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1107-1260 8.68e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 59.98  E-value: 8.68e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1107 PLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALmdkegltaLSWACLKGHLsvV 1186
Cdd:PHA02874    38 PLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSI--------LPIPCIEKDM--I 107

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217311057 1187 RSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGA 1260
Cdd:PHA02874   108 KTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGA 181
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
1294-1407 9.83e-09

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 58.00  E-value: 9.83e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1294 LMEEGDMFYKKGKVKEAAQRYQYALKKFPRegfgedlktfrelKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYE 1373
Cdd:COG4785     76 YYERGVAYDSLGDYDLAIADFDQALELDPD-------------LAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAY 142

                           90       100       110
                   ....*....|....*....|....*....|....
gi 2217311057 1374 AYYARARAKRSSRQFAAALEDLNEAIKLCPNNRE 1407
Cdd:COG4785    143 AYLNRGIALYYLGRYELAIADLEKALELDPNDPE 176
Ank_4 pfam13637
Ankyrin repeats (many copies);
1137-1190 1.16e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 53.05  E-value: 1.16e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2217311057 1137 GRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLV 1190
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1120-1240 1.45e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 59.91  E-value: 1.45e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1120 VDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVdnGAATDHA 1199
Cdd:PTZ00322    98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS--RHSQCHF 175

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 2217311057 1200 DKNGRTPLDlaAFYGdaeVVQFLVDHGAMIEHVDYSGM-RPL 1240
Cdd:PTZ00322   176 ELGANAKPD--SFTG---KPPSLEDSPISSHHPDFSAVpQPM 212
Ank_4 pfam13637
Ankyrin repeats (many copies);
955-1008 2.11e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 52.28  E-value: 2.11e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2217311057  955 GLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLI 1008
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1061-1225 2.61e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 58.74  E-value: 2.61e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1061 AQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTP 1140
Cdd:PHA02878   158 ADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTP 237

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1141 LMMAASE-GHLGTVDFLLAQGASI-ALMDKEGLTALswaclkgHLS-----VVRSLVDNGAATDHADKNGRTPLDLAAF- 1212
Cdd:PHA02878   238 LHISVGYcKDYDILKLLLEHGVDVnAKSYILGLTAL-------HSSikserKLKLLLEYGADINSLNSYKLTPLSSAVKq 310

                          170
                   ....*....|...
gi 2217311057 1213 YGDAEVVQFLVDH 1225
Cdd:PHA02878   311 YLCINIGRILISN 323
Ank_4 pfam13637
Ankyrin repeats (many copies);
1203-1256 3.48e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.51  E-value: 3.48e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2217311057 1203 GRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLL 1256
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
1267-1405 3.73e-08

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 56.08  E-value: 3.73e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1267 LPSRPRGPATWAMATSKPDIMiillSKLMEEGDMFYKkgkVKEAAQRYQYALKKFPREGFGEDLKTFRELK----VSLLL 1342
Cdd:COG4785      5 ALALLLALALAAAAASKAAIL----LAALLFAAVLAL---AIALADLALALAAAALAAAALAAERIDRALAlpdlAQLYY 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217311057 1343 NLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNN 1405
Cdd:COG4785     78 ERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDY 140
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1298-1418 3.89e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 57.05  E-value: 3.89e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1298 GDMFYKKGKVKEAAQRYQYALKKFPRegfgedlktfrelKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1377
Cdd:COG2956     49 GNLYRRRGEYDRAIRIHQKLLERDPD-------------RAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRL 115

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 2217311057 1378 RARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLRVEEE 1418
Cdd:COG2956    116 LAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLE 156
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 1298-1383 4.03e-08

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 53.46  E-value: 4.03e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1298 GDMFYKKGKVKEAAQRYQYALKKFPREGFGEDLktfrelkvslLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1377
Cdd:COG1729     37 GEAYYALGDYDEAAEAFEKLLKRYPDSPKAPDA----------LLKLGLSYLELGDYDKARATLEELIKKYPDSEAAKEA 106


                   ....*.
gi 2217311057 1378 RARAKR 1383
Cdd:COG1729    107 RARLAR 112
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1337-1412 4.73e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 54.04  E-value: 4.73e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217311057 1337 KVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLL 1412
Cdd:COG4783      3 CAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNL 78
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1286-1415 4.84e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 56.66  E-value: 4.84e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1286 IMIILLSKLMEEGDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKAL 1365
Cdd:COG2956      3 LPVAAALGWYFKGLNYLLNGQPDKAIDLLEEALELDPET-------------VEAHLALGNLYRRRGEYDRAIRIHQKLL 69

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1366 ELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLRV 1415
Cdd:COG2956     70 ERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEI 119
Ank_2 pfam12796
Ankyrin repeats (3 copies);
904-985 5.82e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 52.04  E-value: 5.82e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057  904 RLLILGGANINYRTEVLNNAPILCVQShlGYTEMVALLLEFgANVDASSEsGLTPLGYAAAAGYLSIVVLLCKKRAKVDH 983
Cdd:pfam12796   14 KLLLENGADANLQDKNGRTALHLAAKN--GHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHLEIVKLLLEKGADINV 89


                   ..
gi 2217311057  984 LD 985
Cdd:pfam12796   90 KD 91
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 899-1134 8.48e-08

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 57.57  E-value: 8.48e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057  899 NIKVSRLLilgGANINYRTEVLNNAPILCVQShLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKR 978
Cdd:PLN03192   506 DLNVGDLL---GDNGGEHDDPNMASNLLTVAS-TGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHA 581

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057  979 AKVDHLDKNGQCALVHAALRGHLEVVKFLIQCdwtmagqqqgvfkkshaiqqaliaaasmgyteivsylldlpekdeeev 1058
Cdd:PLN03192   582 CNVHIRDANGNTALWNAISAKHHKIFRILYHF------------------------------------------------ 613

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217311057 1059 erAQINsfDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMAD 1134
Cdd:PLN03192   614 --ASIS--DPHAAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKAN 685
Ank_4 pfam13637
Ankyrin repeats (many copies);
1107-1157 1.16e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.97  E-value: 1.16e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2217311057 1107 PLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLL 1157
Cdd:pfam13637    4 ALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
1347-1418 1.86e-07

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 50.94  E-value: 1.86e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217311057 1347 CRRKMNDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQFAAALEdLNEAIKLCPNNREIQRLLLRVEEE 1418
Cdd:COG3063      1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLE 71
Ank_4 pfam13637
Ankyrin repeats (many copies);
924-974 2.33e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.20  E-value: 2.33e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2217311057  924 PILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLL 974
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1294-1418 6.65e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 53.19  E-value: 6.65e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1294 LMEEGDMFYKKGKVKEAAQRYQYALKKFPRegfgedlktfrelKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYE 1373
Cdd:COG2956    147 YCELAELYLEQGDYDEAIEALEKALKLDPD-------------CARALLLLAELYLEQGDYEEAIAALERALEQDPDYLP 213

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 2217311057 1374 AYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLRVEEE 1418
Cdd:COG2956    214 ALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLALADLLERK 258
Ank_5 pfam13857
Ankyrin repeats (many copies);
1123-1174 9.56e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 47.73  E-value: 9.56e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2217311057 1123 LLTHG-ADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTAL 1174
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
Ank_5 pfam13857
Ankyrin repeats (many copies);
1167-1210 1.44e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 46.96  E-value: 1.44e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2217311057 1167 DKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLA 1210
Cdd:pfam13857   13 DGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 1301-1410 2.01e-06

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 48.45  E-value: 2.01e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1301 FYKKGKVKEAAQRYQYALKKFPREgfgedlktfrELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSY---EAYYA 1377
Cdd:COG1729      3 LLKAGDYDEAIAAFKAFLKRYPNS----------PLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPkapDALLK 72

                           90       100       110
                   ....*....|....*....|....*....|...
gi 2217311057 1378 RARAKRSSRQFAAALEDLNEAIKLCPNNREIQR 1410
Cdd:COG1729     73 LGLSYLELGDYDKARATLEELIKKYPDSEAAKE 105
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 957-1223 3.61e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.94  E-value: 3.61e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057  957 TPLGYAAAAGYL-SIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQqqgvfkkshaiqqaliaa 1035
Cdd:cd22192     19 SPLLLAAKENDVqAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPELVNE------------------ 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1036 asmgytEIVSyllDLPEkdeeeveraqinsfdslwGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAV--------- 1106
Cdd:cd22192     81 ------PMTS---DLYQ------------------GETALHIAVVNQNLNLVRELIARGADVVSPRATGTFfrpgpknli 133

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1107 -----PLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTV----DFLLAqgasialMDKEgltalswa 1177
Cdd:cd22192    134 yygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFAcqmyDLILS-------YDKE-------- 198

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 2217311057 1178 clkghlsvvrslvDNGAATDH-ADKNGRTPLDLAAFYGDAEVVQFLV 1223
Cdd:cd22192    199 -------------DDLQPLDLvPNNQGLTPFKLAAKEGNIVMFQHLV 232
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 897-1130 1.78e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 50.06  E-value: 1.78e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057  897 TPNIkvsRLLILGGANINyRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCK 976
Cdd:PHA02876   321 TENI---RTLIMLGADVN-AADRLYITPLHQASTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLD 396

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057  977 KRAKVDHLDKNGQCALvHAALRGhlevvkfliqcdwtmagqqqgvfkkshaiqqaliaaaSMGYTEiVSYLLDlpekdee 1056
Cdd:PHA02876   397 YGADIEALSQKIGTAL-HFALCG-------------------------------------TNPYMS-VKTLID------- 430

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217311057 1057 evERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFstVRQGHWQIVDLLLTHGADV 1130
Cdd:PHA02876   431 --RGANVNSKNKDLSTPLHYACKKNCKLDVIEMLLDNGADVNAINIQNQYPLL--IALEYHGIVNILLHYGAEL 500
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1294-1400 2.27e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 48.19  E-value: 2.27e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1294 LMEEGDMFYKKGKVKEAAQRYQYALKKFPRegfgedlktfrelKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPkSYE 1373
Cdd:COG2956    181 LLLLAELYLEQGDYEEAIAALERALEQDPD-------------YLPALPRLAELYEKLGDPEEALELLRKALELDP-SDD 246

                           90       100
                   ....*....|....*....|....*..
gi 2217311057 1374 AYYARARAKRSSRQFAAALEDLNEAIK 1400
Cdd:COG2956    247 LLLALADLLERKEGLEAALALLERQLR 273
PHA02946 PHA02946
ankyin-like protein; Provisional
 1090-1240 4.58e-05

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 48.13  E-value: 4.58e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1090 LLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPL--MMAASEGHLGTVDFLLAQGASI-ALM 1166
Cdd:PHA02946    58 LLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLyyLSGTDDEVIERINLLVQYGAKInNSV 137

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217311057 1167 DKEGLTALsWACLKGHLSVVRSLVDNGAATDHADKNGRTPL--DLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPL 1240
Cdd:PHA02946   138 DEEGCGPL-LACTDPSERVFKKIMSIGFEARIVDKFGKNHIhrHLMSDNPKASTISWMMKLGISPSKPDHDGNTPL 212
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 1299-1414 4.75e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.54  E-value: 4.75e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1299 DMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYAR 1378
Cdd:TIGR02917  507 RIDIQEGNPDDAIQRFEKVLTIDPKN-------------LRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALAL 573

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2217311057 1379 ARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLR 1414
Cdd:TIGR02917  574 AQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGR 609
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1106-1262 5.85e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 47.95  E-value: 5.85e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1106 VPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLA--------------------QGASIAL 1165
Cdd:PHA02878    39 IPLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRsinkcsvfytlvaikdafnnRNVEIFK 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1166 M------DKEGLTALSWACLKGH-----LSVVRSLVDNGAATDHADKN-GRTPLDLAAFYGDAEVVQFLVDHGAMIEHVD 1233
Cdd:PHA02878   119 IiltnryKNIQTIDLVYIDKKSKddiieAEITKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPD 198

                          170       180
                   ....*....|....*....|....*....
gi 2217311057 1234 YSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1262
Cdd:PHA02878   199 KTNNSPLHHAVKHYNKPIVHILLENGAST 227
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1088-1157 8.03e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.59  E-value: 8.03e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217311057 1088 RLLLEQGAavaQPNRR---GAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLL 1157
Cdd:PTZ00322    99 RILLTGGA---DPNCRdydGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
1366-1414 1.18e-04

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 45.68  E-value: 1.18e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2217311057 1366 ELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCP------NNREIQRLLLR 1414
Cdd:COG4785     67 LALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPdlaeayNNRGLAYLLLG 121
TPR_14 pfam13428
Tetratricopeptide repeat;
1373-1415 1.39e-04

Tetratricopeptide repeat;


Pssm-ID: 463874 [Multi-domain]  Cd Length: 44  Bit Score: 41.25  E-value: 1.39e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2217311057 1373 EAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLRV 1415
Cdd:pfam13428    2 EALLALARALLALGDPDEALALLERALALDPDDPEAWLALAQL 44
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1202-1230 1.43e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.65  E-value: 1.43e-04
                            10        20
                    ....*....|....*....|....*....
gi 2217311057  1202 NGRTPLDLAAFYGDAEVVQFLVDHGAMIE 1230
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 1335-1415 1.57e-04

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 46.06  E-value: 1.57e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1335 ELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEA-YYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLL 1413
Cdd:COG3071     47 EAPLLAYLLAARAAQALGDYERRDEYLAQALELAPEAELAvLLTRAELLLDQGQAEQALATLEALRAGAPRHPQVLRLLL 126


                   ..
gi 2217311057 1414 RV 1415
Cdd:COG3071    127 QA 128
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1202-1233 2.28e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 40.35  E-value: 2.28e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2217311057 1202 NGRTPLDLAA-FYGDAEVVQFLVDHGAMIEHVD 1233
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1136-1168 2.42e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.97  E-value: 2.42e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2217311057 1136 QGRTPLMMAA-SEGHLGTVDFLLAQGASIALMDK 1168
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1365-1412 2.97e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 44.61  E-value: 2.97e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2217311057 1365 LELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLL 1412
Cdd:COG0457      1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNL 48
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1349-1422 3.03e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 45.75  E-value: 3.03e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217311057 1349 RKMNDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLRVEEECRQM 1422
Cdd:COG3914     89 QALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRL 162
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 1053-1230 3.77e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 45.46  E-value: 3.77e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1053 KDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQgaavaqpNRRGAV--PLFSTVRQGHWQIVDLLLTHGADV 1130
Cdd:TIGR00870   35 RDLEEPKKLNINCPDRLGRSALFVAAIENENLELTELLLNL-------SCRGAVgdTLLHAISLEYVDAVEAILLHLLAA 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1131 nmADKQGRTPLMMAASeghlgTVDFllaqgasialmdKEGLTALSWACLKGHLSVVRSLVDNGAA------------TDH 1198
Cdd:TIGR00870  108 --FRKSGPLELANDQY-----TSEF------------TPGITALHLAAHRQNYEIVKLLLERGASvparacgdffvkSQG 168

                          170       180       190
                   ....*....|....*....|....*....|....
gi 2217311057 1199 AD--KNGRTPLDLAAFYGDAEVVQFLVDHGAMIE 1230
Cdd:TIGR00870  169 VDsfYHGESPLNAAACLGSPSIVALLSEDPADIL 202
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1474-1703 4.19e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 4.19e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1474 LQTEARPSQGLPVIQSP-PSSPPHRDSAYISSSPLGShqvfdfrsSSSVGSPTRQTYQSTSPALSPTHqnshyRPSPPht 1552
Cdd:PHA03247  2818 LPPAASPAGPLPPPTSAqPTAPPPPPGPPPPSLPLGG--------SVAPGGDVRRRPPSRSPAAKPAA-----PARPP-- 2882

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1553 spahqggSYRFSPPPVGGQGKEYPSPPpSPLRRGPQYRASPPAesmsvyRSQSGSPVRyQQETSVSQLPGRPKSPLSKMA 1632
Cdd:PHA03247  2883 -------VRRLARPAVSRSTESFALPP-DQPERPPQPQAPPPP------QPQPQPPPP-PQPQPPPPPPPRPQPPLAPTT 2947

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1633 Q-RPYQMPQLPVAVPQQGlRLQPAKAQIVRSNQPSPA---------VHSSTVIPTGAYGQVAHSMASKYQSSQGDIGVSQ 1702
Cdd:PHA03247  2948 DpAGAGEPSGAVPQPWLG-ALVPGRVAVPRFRVPQPApsreapassTPPLTGHSLSRVSSWASSLALHEETDPPPVSLKQ 3026


                   .
gi 2217311057 1703 S 1703
Cdd:PHA03247  3027 T 3027
Ank_5 pfam13857
Ankyrin repeats (many copies);
1090-1144 5.84e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 39.64  E-value: 5.84e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217311057 1090 LLEQG-AAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMA 1144
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1298-1413 6.96e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 44.60  E-value: 6.96e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1298 GDMFYKKGKVKEAAQRYQYALKKFPREgfgedlktfrelkVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1377
Cdd:COG3914    153 GEALRRLGRLEEAIAALRRALELDPDN-------------AEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSN 219

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2217311057 1378 RARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLL 1413
Cdd:COG3914    220 LLFALRQACDWEVYDRFEELLAALARGPSELSPFAL 255
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 898-1009 7.52e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 44.49  E-value: 7.52e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057  898 PNIKVSRLLILGGANINYrTEVLNNAPILCVQSHLGyTEMVALLLEFGANVDASSESGLTPLGYaaAAGYL---SIVVLL 974
Cdd:PHA02878   179 KDQRLTELLLSYGANVNI-PDKTNNSPLHHAVKHYN-KPIVHILLENGASTDARDKCGNTPLHI--SVGYCkdyDILKLL 254

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2217311057  975 CKKRAKVDHLDKNGQCALVHAALRGHlEVVKFLIQ 1009
Cdd:PHA02878   255 LEHGVDVNAKSYILGLTALHSSIKSE-RKLKLLLE 288
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 1298-1415 8.42e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 44.69  E-value: 8.42e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1298 GDMFYKKGKVKEAAQRYQYALKKFPREGfgedlktfrelkvSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYA 1377
Cdd:TIGR02917  132 GLAYLGLGQLELAQKSYEQALAIDPRSL-------------YAKLGLAQLALAENRFDEARALIDEVLTADPGNVDALLL 198

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2217311057 1378 RARAKRSSRQFAAALEDLNEAIKLCPNNreIQRLLLRV 1415
Cdd:TIGR02917  199 KGDLLLSLGNIELALAAYRKAIALRPNN--IAVLLALA 234
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 1137-1229 8.45e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 44.49  E-value: 8.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1137 GRTPLMMAASEGHLGTVD--FLLAQGASIALMDKE------------GLTALSWACLKGHLSVVRSLVDNGAATdHADKN 1202
Cdd:cd21882     26 GKTCLHKAALNLNDGVNEaiMLLLEAAPDSGNPKElvnapctdefyqGQTALHIAIENRNLNLVRLLVENGADV-SARAT 104

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 2217311057 1203 GRT--------------PLDLAAFYGDAEVVQFLVDHGAMI 1229
Cdd:cd21882    105 GRFfrkspgnlfyfgelPLSLAACTNQEEIVRLLLENGAQP 145
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1186-1256 9.51e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.12  E-value: 9.51e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217311057 1186 VRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGcRNTSVVVTLL 1256
Cdd:PTZ00322    98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEE-NGFREVVQLL 167
Ank_5 pfam13857
Ankyrin repeats (many copies);
1189-1243 1.20e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.87  E-value: 1.20e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217311057 1189 LVDNG-AATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRA 1243
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
TPR_1 pfam00515
Tetratricopeptide repeat;
1372-1405 1.24e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 38.17  E-value: 1.24e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2217311057 1372 YEAYYARARAKRSSRQFAAALEDLNEAIKLCPNN 1405
Cdd:pfam00515    1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 1071-1223 1.37e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 43.72  E-value: 1.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1071 GETALTAAA---GRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGH-----------WQIVDLLLTHGADVNMA--- 1133
Cdd:cd21882     26 GKTCLHKAAlnlNDGVNEAIMLLLEAAPDSGNPKELVNAPCTDEFYQGQtalhiaienrnLNLVRLLVENGADVSARatg 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1134 ---DKQGRT-------PLMMAASEGHLGTVDFLL---AQGASIALMDKEGLTALSWACLKGHLSVVRS---------LVD 1191
Cdd:cd21882    106 rffRKSPGNlfyfgelPLSLAACTNQEEIVRLLLengAQPAALEAQDSLGNTVLHALVLQADNTPENSafvcqmynlLLS 185

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 2217311057 1192 NGAATDH-------ADKNGRTPLDLAAFYGDAEVVQFLV 1223
Cdd:cd21882    186 YGAHLDPtqqleeiPNHQGLTPLKLAAVEGKIVMFQHIL 224
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1136-1163 1.40e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 1.40e-03
                            10        20
                    ....*....|....*....|....*...
gi 2217311057  1136 QGRTPLMMAASEGHLGTVDFLLAQGASI 1163
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADI 28
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 900-1008 1.57e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 43.06  E-value: 1.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057  900 IKVSRLLILGganiNYRTEVL---NNAPiLCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCK 976
Cdd:PHA02875    82 KAVEELLDLG----KFADDVFykdGMTP-LHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLID 156

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2217311057  977 KRAKVDHLDKNGQCALVHAALRGHLEVVKFLI 1008
Cdd:PHA02875   157 HKACLDIEDCCGCTPLIIAMAKGDIAICKMLL 188
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 926-1010 1.58e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 43.35  E-value: 1.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057  926 LCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVK 1005
Cdd:PTZ00322    86 LCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165


                   ....*
gi 2217311057 1006 FLIQC 1010
Cdd:PTZ00322   166 LLSRH 170
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1071-1258 1.63e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 43.46  E-value: 1.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1071 GETALTAAAGRGKLEVCRLLLEqgaavaqpnrrgAVPlfstvrqghwqivDLllthgadVNMADK----QGRTPLMMAAS 1146
Cdd:cd22192     51 GETALHVAALYDNLEAAVVLME------------AAP-------------EL-------VNEPMTsdlyQGETALHIAVV 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1147 EGHLGTVDFLLAQGASIA---------LMDKEGLT-----ALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAF 1212
Cdd:cd22192     99 NQNLNLVRELIARGADVVspratgtffRPGPKNLIyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVL 178

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217311057 1213 YGDA----EVVQFLV-----DHGAMIEHV-DYSGMRPLDRAVGCRNTSVVVTLLKK 1258
Cdd:cd22192    179 QPNKtfacQMYDLILsydkeDDLQPLDLVpNNQGLTPFKLAAKEGNIVMFQHLVQK 234
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1484-1676 1.72e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.60  E-value: 1.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1484 LPVIQSPPSSP-PHRDSAYISSSPLGSHQVFDFRSSSSVGSPtrqtyqstsPALSPTHQNSHYRPSPPHtspahqggsyr 1562
Cdd:pfam03154  352 MPHIKPPPTTPiPQLPNPQSHKHPPHLSGPSPFQMNSNLPPP---------PALKPLSSLSTHHPPSAH----------- 411

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1563 fsPPPVggqgkeypspppsPLRRGPQYRASPPAESMSVYRSQSGSPVRYQQETSVSQLPGRPKSPLSKMAQRPYQMPQL- 1641
Cdd:pfam03154  412 --PPPL-------------QLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPIt 476

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 2217311057 1642 -----PVAVPQQGLRLQPAKAQIVRSNQPSPAVHSSTVIP 1676
Cdd:pfam03154  477 ppsgpPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPP 516
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1202-1227 1.96e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 37.62  E-value: 1.96e-03
                           10        20
                   ....*....|....*....|....*.
gi 2217311057 1202 NGRTPLDLAAFYGDAEVVQFLVDHGA 1227
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGA 26
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 1352-1403 2.20e-03

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 42.47  E-value: 2.20e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2217311057 1352 NDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCP 1403
Cdd:PLN03088    16 DDFALAVDLYTQAIDLDPNNAELYADRAQANIKLGNFTEAVADANKAIELDP 67
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 904-988 2.36e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.96  E-value: 2.36e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057  904 RLLILGGANINYRTevLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDH 983
Cdd:PTZ00322    99 RILLTGGADPNCRD--YDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFE 176


                   ....*
gi 2217311057  984 LDKNG 988
Cdd:PTZ00322   177 LGANA 181
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 1071-1223 2.41e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 43.15  E-value: 2.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1071 GETALTAAAGRGKLEVCRLLLEQGAAV-AQPN-----RRGAVPLFSTVRQ--------GHWQIVDLLLTHGADVNMADKQ 1136
Cdd:TIGR00870  128 GITALHLAAHRQNYEIVKLLLERGASVpARACgdffvKSQGVDSFYHGESplnaaaclGSPSIVALLSEDPADILTADSL 207

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1137 GRTPLMMAASEGhlgtvDFllaqgasialmdKEGLTALSWAC---LKGHLSVVRSLVDNGAATDHadkNGRTPLDLAAFY 1213
Cdd:TIGR00870  208 GNTLLHLLVMEN-----EF------------KAEYEELSCQMynfALSLLDKLRDSKELEVILNH---QGLTPLKLAAKE 267

                          170
                   ....*....|
gi 2217311057 1214 GDAEVVQFLV 1223
Cdd:TIGR00870  268 GRIVLFRLKL 277
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 1373-1404 2.48e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 37.12  E-value: 2.48e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2217311057 1373 EAYYARARAKRSSRQFAAALEDLNEAIKLCPN 1404
Cdd:pfam07719    2 EALYNLGLAYYKLGDYEEALEAYEKALELDPN 33
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 920-1009 2.94e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 41.34  E-value: 2.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057  920 LNNAPIL-CVQSHLGYTEMVALLLEFGANVD-ASSESGLTPLGYaaaagYLS--------IVVLLCKKRAKVDHLDKNGQ 989
Cdd:PHA02859    50 LYETPIFsCLEKDKVNVEILKFLIENGADVNfKTRDNNLSALHH-----YLSfnknvepeILKILIDSGSSITEEDEDGK 124

                           90       100
                   ....*....|....*....|...
gi 2217311057  990 cALVHAALRG---HLEVVKFLIQ 1009
Cdd:PHA02859   125 -NLLHMYMCNfnvRINVIKLLID 146
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1485-1654 3.21e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.83  E-value: 3.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1485 PVIQS------PPSSPPHRDSAYISSSPLGSHQVFDFRSSSSVGSPTRQTyQSTSPALSPTHQNSHYR----PSP----- 1549
Cdd:pfam03154  172 PVLQAqsgaasPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQT-QSTAAPHTLIQQTPTLHpqrlPSPhpplq 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1550 --PHTSPAHQGGSYRFSPPPVGGQGKEypspPPSPLRRGPQYRASPPAEsmsvyrsqsgSPVRYQQETSVSQLPGRPKSP 1627
Cdd:pfam03154  251 pmTQPPPPSQVSPQPLPQPSLHGQMPP----MPHSLQTGPSHMQHPVPP----------QPFPLTPQSSQSQVPPGPSPA 316

                          170       180
                   ....*....|....*....|....*...
gi 2217311057 1628 LSKMA-QRPYQMPQLPVAVPQQGLRLQP 1654
Cdd:pfam03154  317 APGQSqQRIHTPPSQSQLQSQQPPREQP 344
TPR_19 pfam14559
Tetratricopeptide repeat;
1352-1412 3.50e-03

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 37.56  E-value: 3.50e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217311057 1352 NDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLL 1412
Cdd:pfam14559    2 GDYAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADPDDPRYAALL 62
TPR_12 pfam13424
Tetratricopeptide repeat;
1339-1401 3.56e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 38.14  E-value: 3.56e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217311057 1339 SLLLNLSRCRRKMNDFGMAEEFATKALEL--------KPKSYEAYYARARAKRSSRQFAAALEDLNEAIKL 1401
Cdd:pfam13424    4 TALNNLAAVLRRLGRYDEALELLEKALEIarrllgpdHPLTATTLLNLGRLYLELGRYEEALELLERALAL 74
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 1083-1163 4.25e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 42.04  E-value: 4.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1083 KLEVCRLLLEQGAAVaqpNRRGAV--PLFSTVRQGHW------QIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVD 1154
Cdd:PHA02989    49 KIKIVKLLIDNGADV---NYKGYIetPLCAVLRNREItsnkikKIVKLLLKFGADINLKTFNGVSPIVCFIYNSNINNCD 125

                           90
                   ....*....|..
gi 2217311057 1155 ---FLLAQGASI 1163
Cdd:PHA02989   126 mlrFLLSKGINV 137
PRK09782 PRK09782
bacteriophage N4 receptor, outer membrane subunit; Provisional
 1348-1409 4.47e-03

bacteriophage N4 receptor, outer membrane subunit; Provisional


Pssm-ID: 236624 [Multi-domain]  Cd Length: 987  Bit Score: 42.21  E-value: 4.47e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217311057 1348 RRKMNDFGMAEEFATKALELKPkSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQ 1409
Cdd:PRK09782   586 RYIPGQPELALNDLTRSLNIAP-SANAYVARATIYRQRHNVPAAVSDLRAALELEPNNSNYQ 646
TPR_12 pfam13424
Tetratricopeptide repeat;
1298-1370 5.17e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 37.75  E-value: 5.17e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217311057 1298 GDMFYKKGKVKEAAQRYQYALKKFpREGFGEDlktfRELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPK 1370
Cdd:pfam13424   10 AAVLRRLGRYDEALELLEKALEIA-RRLLGPD----HPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 1372-1405 5.42e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 36.27  E-value: 5.42e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 2217311057  1372 YEAYYARARAKRSSRQFAAALEDLNEAIKLCPNN 1405
Cdd:smart00028    1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1137-1163 5.72e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.08  E-value: 5.72e-03
                           10        20
                   ....*....|....*....|....*..
gi 2217311057 1137 GRTPLMMAASEGHLGTVDFLLAQGASI 1163
Cdd:pfam13606    2 GNTPLHLAARNGRLEIVKLLLENGADI 28
Ank_5 pfam13857
Ankyrin repeats (many copies);
905-962 6.71e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.56  E-value: 6.71e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2217311057  905 LLILGGANINYRTEVLNNApiLCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYA 962
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTP--LHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 1039-1223 6.72e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 41.28  E-value: 6.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1039 GYTEIVSYLLDLPEKDEEEVEraqinsfdslwgeTALTAAAGRGKLEvcRLLleqGAAVAQPNRRGAVPLFSTVRQGHWQ 1118
Cdd:cd22194     94 GKTCLMKALLNINENTKEIVR-------------ILLAFAEENGILD--RFI---NAEYTEEAYEGQTALNIAIERRQGD 155

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1119 IVDLLLTHGADVNMADKQ--------------GRTPLMMAASEGHLGTVDFLLAQGAS-IALMDKEG---LTALSWAC-- 1178
Cdd:cd22194    156 IVKLLIAKGADVNAHAKGvffnpkykhegfyfGETPLALAACTNQPEIVQLLMEKESTdITSQDSRGntvLHALVTVAed 235

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2217311057 1179 LKGHLSVVRSLVDNgAATDHADKN--------GRTPLDLAAFYGDAEVVQFLV 1223
Cdd:cd22194    236 SKTQNDFVKRMYDM-ILLKSENKNletirnneGLTPLQLAAKMGKAEILKYIL 287
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1181-1268 7.90e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 41.10  E-value: 7.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1181 GHLSVVRSLVDN-GAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKG 1259
Cdd:PHA02874    12 GDIEAIEKIIKNkGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNG 91


                   ....*....
gi 2217311057 1260 AKIGCQTLP 1268
Cdd:PHA02874    92 VDTSILPIP 100
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1488-1641 9.84e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.31  E-value: 9.84e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311057 1488 QSPPSSPPHRDSAYISSSPLGSHQVFDFRSSSSVGSPTRQTYQSTSPALSPTHQNSHYRPSPPHTSPAHQGGSYRFSPPP 1567
Cdd:PHA03307   285 ASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSS 364

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217311057 1568 vggqgkeypSPPPSPLRRGPQYRASPPAESMS-VYRSQSGSPVRYQQETSVSQLPGRPKSPL--SKMAQRPYQMPQL 1641
Cdd:PHA03307   365 ---------PRKRPRPSRAPSSPAASAGRPTRrRARAAVAGRARRRDATGRFPAGRPRPSPLdaGAASGAFYARYPL 432
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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