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Conserved domains on  [gi|2217305887|ref|XP_047290029|]
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integrin alpha-L isoform X4 [Homo sapiens]

Protein Classification

Int_alpha and Integrin_alpha domain-containing protein( domain architecture ID 12192598)

protein containing domains Int_alpha, Integrin_alpha2, and Integrin_alpha

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Integrin_alpha2 super family cl26747
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 285-670 4.61e-36

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


The actual alignment was detected with superfamily member pfam08441:

Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 142.07  E-value: 4.61e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305887 285 RPVVDMVTLMSFSPAEIPVHEVECSysTSNKMKEGVNITICFQIkSLIPQFQGRLVanLTYTLQLDghRTRRRGLFP--- 361
Cdd:pfam08441   1 RPVVSVSASLQVEPNSINPEKKNCT--LTGTPVSCFTVRACFSY-TGKPIPNPSLV--LNYELELD--RQKKKGLPPrvl 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305887 362 ---GGRHELRRNIAVTTSMS--CTDFSFHFPVCVQDLISPINVSLNFSLweeegtPRDQRAGKDIPPiLRPSLH-----S 431
Cdd:pfam08441  74 fldSQQPSLTGTLVLLSQGRkvCRTTKAYLRDEFRDKLSPIVISLNYSL------RVDPRAPSDLPG-LKPILDqnqpsT 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305887 432 ETWEIPFEKNCGEDKKCEANLRVSFSPARSRA---LRLTAFASLSVELSLSNLEEDAYWVQLDLHFPPGLSFRKVEMLKP 508
Cdd:pfam08441 147 VQEQANFLKDCGEDNVCVPDLQLSAKFDSRESdepLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGVRREGS 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305887 509 HSQipVSCEELPEESrllSRALSCNVSSPiFKAGHSVALQMMFNTLVNSSWGDSVELHANVTCNNEDSDllEDNSATTII 588
Cdd:pfam08441 227 EKQ--LSCTAKKENS---TRQVVCDLGNP-MKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNS--NSNPVSLKV 298

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305887 589 PILYPINILIQDQEDSTLYVSFTPKG-PKIH---------QVKHMYQVRIQ-PSihdhNIPTLEAVVGVPQPPSEGP--- 654
Cdd:pfam08441 299 PVVAEAQLSLSGVSKPDQVVGGSVKGeSAMKprseedigpLVEHTYEVINNgPS----TVSGASLEISWPYELSNGKwll 374

                         410
                  ....*....|....*..
gi 2217305887 655 -ITHqwsVQMEPPVPCH 670
Cdd:pfam08441 375 yLLD---VQGQGKGECS 388
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 189-241 1.94e-13

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 65.47  E-value: 1.94e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217305887  189 PLGRFGEAITALTDINGDGLVDVAVGAPLE----EQGAVYIFNGRHGGLSPQPSQRI 241
Cdd:smart00191   1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRAndagETGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 128-175 9.24e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 51.99  E-value: 9.24e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2217305887  128 IGSYFGGELCGV-DVDQDGETELLlIGAPLFYGEQRGGRVFIYQRRQLG 175
Cdd:smart00191   1 PGSYFGYSVAGVgDVNGDGYPDLL-VGAPRANDAGETGAVYVYFGSSGG 48
Integrin_alpha pfam00357
Integrin alpha cytoplasmic region; This family contains the short intracellular region of ...
 784-798 1.75e-03

Integrin alpha cytoplasmic region; This family contains the short intracellular region of integrin alpha chains.


:

Pssm-ID: 459778  Cd Length: 15  Bit Score: 36.32  E-value: 1.75e-03
                          10
                  ....*....|....*
gi 2217305887 784 KVGFFKRNLKEKMEA 798
Cdd:pfam00357   1 KCGFFKRNYPPQEEE 15
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 251-275 2.29e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 36.97  E-value: 2.29e-03
                           10        20
                   ....*....|....*....|....*
gi 2217305887  251 QWFGRSIHGVKDLEGDGLADVAVGA 275
Cdd:smart00191   3 SYFGYSVAGVGDVNGDGYPDLLVGA 27
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 285-670 4.61e-36

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 142.07  E-value: 4.61e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305887 285 RPVVDMVTLMSFSPAEIPVHEVECSysTSNKMKEGVNITICFQIkSLIPQFQGRLVanLTYTLQLDghRTRRRGLFP--- 361
Cdd:pfam08441   1 RPVVSVSASLQVEPNSINPEKKNCT--LTGTPVSCFTVRACFSY-TGKPIPNPSLV--LNYELELD--RQKKKGLPPrvl 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305887 362 ---GGRHELRRNIAVTTSMS--CTDFSFHFPVCVQDLISPINVSLNFSLweeegtPRDQRAGKDIPPiLRPSLH-----S 431
Cdd:pfam08441  74 fldSQQPSLTGTLVLLSQGRkvCRTTKAYLRDEFRDKLSPIVISLNYSL------RVDPRAPSDLPG-LKPILDqnqpsT 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305887 432 ETWEIPFEKNCGEDKKCEANLRVSFSPARSRA---LRLTAFASLSVELSLSNLEEDAYWVQLDLHFPPGLSFRKVEMLKP 508
Cdd:pfam08441 147 VQEQANFLKDCGEDNVCVPDLQLSAKFDSRESdepLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGVRREGS 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305887 509 HSQipVSCEELPEESrllSRALSCNVSSPiFKAGHSVALQMMFNTLVNSSWGDSVELHANVTCNNEDSDllEDNSATTII 588
Cdd:pfam08441 227 EKQ--LSCTAKKENS---TRQVVCDLGNP-MKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNS--NSNPVSLKV 298

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305887 589 PILYPINILIQDQEDSTLYVSFTPKG-PKIH---------QVKHMYQVRIQ-PSihdhNIPTLEAVVGVPQPPSEGP--- 654
Cdd:pfam08441 299 PVVAEAQLSLSGVSKPDQVVGGSVKGeSAMKprseedigpLVEHTYEVINNgPS----TVSGASLEISWPYELSNGKwll 374

                         410
                  ....*....|....*..
gi 2217305887 655 -ITHqwsVQMEPPVPCH 670
Cdd:pfam08441 375 yLLD---VQGQGKGECS 388
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 189-241 1.94e-13

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 65.47  E-value: 1.94e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217305887  189 PLGRFGEAITALTDINGDGLVDVAVGAPLE----EQGAVYIFNGRHGGLSPQPSQRI 241
Cdd:smart00191   1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRAndagETGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 128-175 9.24e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 51.99  E-value: 9.24e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2217305887  128 IGSYFGGELCGV-DVDQDGETELLlIGAPLFYGEQRGGRVFIYQRRQLG 175
Cdd:smart00191   1 PGSYFGYSVAGVgDVNGDGYPDLL-VGAPRANDAGETGAVYVYFGSSGG 48
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 193-226 1.04e-07

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 48.66  E-value: 1.04e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2217305887 193 FGEAItALTDINGDGLVDVAVGAPLE---EQGAVYIF 226
Cdd:pfam01839   1 FGYSV-AVGDLNGDGYADLAVGAPGEggaGAGAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 132-169 2.89e-04

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 38.65  E-value: 2.89e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2217305887 132 FGGELCGVDVDQDGETElLLIGAPlFYGEQRGGRVFIY 169
Cdd:pfam01839   1 FGYSVAVGDLNGDGYAD-LAVGAP-GEGGAGAGAVYVL 36
Integrin_alpha pfam00357
Integrin alpha cytoplasmic region; This family contains the short intracellular region of ...
 784-798 1.75e-03

Integrin alpha cytoplasmic region; This family contains the short intracellular region of integrin alpha chains.


Pssm-ID: 459778  Cd Length: 15  Bit Score: 36.32  E-value: 1.75e-03
                          10
                  ....*....|....*
gi 2217305887 784 KVGFFKRNLKEKMEA 798
Cdd:pfam00357   1 KCGFFKRNYPPQEEE 15
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 251-275 2.29e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 36.97  E-value: 2.29e-03
                           10        20
                   ....*....|....*....|....*
gi 2217305887  251 QWFGRSIHGVKDLEGDGLADVAVGA 275
Cdd:smart00191   3 SYFGYSVAGVGDVNGDGYPDLLVGA 27
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 285-670 4.61e-36

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 142.07  E-value: 4.61e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305887 285 RPVVDMVTLMSFSPAEIPVHEVECSysTSNKMKEGVNITICFQIkSLIPQFQGRLVanLTYTLQLDghRTRRRGLFP--- 361
Cdd:pfam08441   1 RPVVSVSASLQVEPNSINPEKKNCT--LTGTPVSCFTVRACFSY-TGKPIPNPSLV--LNYELELD--RQKKKGLPPrvl 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305887 362 ---GGRHELRRNIAVTTSMS--CTDFSFHFPVCVQDLISPINVSLNFSLweeegtPRDQRAGKDIPPiLRPSLH-----S 431
Cdd:pfam08441  74 fldSQQPSLTGTLVLLSQGRkvCRTTKAYLRDEFRDKLSPIVISLNYSL------RVDPRAPSDLPG-LKPILDqnqpsT 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305887 432 ETWEIPFEKNCGEDKKCEANLRVSFSPARSRA---LRLTAFASLSVELSLSNLEEDAYWVQLDLHFPPGLSFRKVEMLKP 508
Cdd:pfam08441 147 VQEQANFLKDCGEDNVCVPDLQLSAKFDSRESdepLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGVRREGS 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305887 509 HSQipVSCEELPEESrllSRALSCNVSSPiFKAGHSVALQMMFNTLVNSSWGDSVELHANVTCNNEDSDllEDNSATTII 588
Cdd:pfam08441 227 EKQ--LSCTAKKENS---TRQVVCDLGNP-MKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNS--NSNPVSLKV 298

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305887 589 PILYPINILIQDQEDSTLYVSFTPKG-PKIH---------QVKHMYQVRIQ-PSihdhNIPTLEAVVGVPQPPSEGP--- 654
Cdd:pfam08441 299 PVVAEAQLSLSGVSKPDQVVGGSVKGeSAMKprseedigpLVEHTYEVINNgPS----TVSGASLEISWPYELSNGKwll 374

                         410
                  ....*....|....*..
gi 2217305887 655 -ITHqwsVQMEPPVPCH 670
Cdd:pfam08441 375 yLLD---VQGQGKGECS 388
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 189-241 1.94e-13

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 65.47  E-value: 1.94e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217305887  189 PLGRFGEAITALTDINGDGLVDVAVGAPLE----EQGAVYIFNGRHGGLSPQPSQRI 241
Cdd:smart00191   1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRAndagETGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 128-175 9.24e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 51.99  E-value: 9.24e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2217305887  128 IGSYFGGELCGV-DVDQDGETELLlIGAPLFYGEQRGGRVFIYQRRQLG 175
Cdd:smart00191   1 PGSYFGYSVAGVgDVNGDGYPDLL-VGAPRANDAGETGAVYVYFGSSGG 48
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 193-226 1.04e-07

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 48.66  E-value: 1.04e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2217305887 193 FGEAItALTDINGDGLVDVAVGAPLE---EQGAVYIF 226
Cdd:pfam01839   1 FGYSV-AVGDLNGDGYADLAVGAPGEggaGAGAVYVL 36
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 202-273 4.05e-05

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 41.83  E-value: 4.05e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217305887 202 DINGDGLVDVAVGAPleEQGAVYIFNGrhgglspqpsqriEGTQVLSGIQWFGRSIHG----VKDLEGDGLADVAV 273
Cdd:pfam13517   1 DLDGDGKLDLVVAND--GGLRLYLNNG-------------DGTFTFITSVSLGGGGGGlsvaVGDLDGDGRLDLLV 61
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 132-169 2.89e-04

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 38.65  E-value: 2.89e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2217305887 132 FGGELCGVDVDQDGETElLLIGAPlFYGEQRGGRVFIY 169
Cdd:pfam01839   1 FGYSVAVGDLNGDGYAD-LAVGAP-GEGGAGAGAVYVL 36
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 140-213 1.32e-03

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 37.59  E-value: 1.32e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217305887 140 DVDQDGETELLLIGAplfygeqrgGRVFIYQRRQLG-FEEVSELQGDPGYplgrFGEAITALtDINGDGLVDVAV 213
Cdd:pfam13517   1 DLDGDGKLDLVVAND---------GGLRLYLNNGDGtFTFITSVSLGGGG----GGLSVAVG-DLDGDGRLDLLV 61
Integrin_alpha pfam00357
Integrin alpha cytoplasmic region; This family contains the short intracellular region of ...
 784-798 1.75e-03

Integrin alpha cytoplasmic region; This family contains the short intracellular region of integrin alpha chains.


Pssm-ID: 459778  Cd Length: 15  Bit Score: 36.32  E-value: 1.75e-03
                          10
                  ....*....|....*
gi 2217305887 784 KVGFFKRNLKEKMEA 798
Cdd:pfam00357   1 KCGFFKRNYPPQEEE 15
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 251-275 2.29e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 36.97  E-value: 2.29e-03
                           10        20
                   ....*....|....*....|....*
gi 2217305887  251 QWFGRSIHGVKDLEGDGLADVAVGA 275
Cdd:smart00191   3 SYFGYSVAGVGDVNGDGYPDLLVGA 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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