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Conserved domains on  [gi|2217271987|ref|XP_047289394|]
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period circadian protein homolog 3 isoform X3 [Homo sapiens]

Protein Classification

PAS and Period_C domain-containing protein( domain architecture ID 12888871)

protein containing domains PAS, Herpes_BLLF1, and Period_C

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Period_C super family cl13540
Period protein 2/3C-terminal region; This domain is found in eukaryotes. This domain is ...
 1082-1184 1.16e-25

Period protein 2/3C-terminal region; This domain is found in eukaryotes. This domain is typically between 164 to 200 amino acids in length. This domain is found associated with pfam08447.


The actual alignment was detected with superfamily member pfam12114:

Pssm-ID: 463464  Cd Length: 171  Bit Score: 104.79  E-value: 1.16e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987 1082 SVYSSKISQNGQQSQDVQKKETF-PNVAEEPIWRMIRQTPERILMTYQVPERVKEVVLKEDLEKLESMRQQQPQFSHGQK 1160
Cdd:pfam12114   68 SIDSSENNHKAKKTAEVGEEEHFiKCVLQDPIWLLMANTDDSVMMTYQIPSRDLETVLKEDREKLKAMQKMQPRFTEDQK 147

                           90       100
                   ....*....|....*....|....
gi 2217271987 1161 EELAKVYNWIQSQTVTQEIDIQAC 1184
Cdd:pfam12114  148 GELAEVHPWIQKGGLPAALDLSEC 171
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 284-376 1.80e-12

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


:

Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 64.58  E-value: 1.80e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  284 FLEVDEKAVPLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLKYAGHPPFEhspIRFCTQNGDYIILDSSWSSFVNPW 363
Cdd:cd00130     14 ILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLSGGEPVTLE---VRLRRKDGSVIWVLVSLTPIRDEG 90

                           90
                   ....*....|...
gi 2217271987  364 SRKISFIIGRHKV 376
Cdd:cd00130     91 GEVIGLLGVVRDI 103
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 751-1062 3.83e-08

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 57.85  E-value: 3.83e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  751 LPEPPDSSSSNTGSgprrgAHQNAQPCCPSAASSPHTSSPTFPPAAMVPSQAPylvPAFPLPAATSPGREYAAPGTAPEG 830
Cdd:pfam03154  148 IPSPQDNESDSDSS-----AQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAA---TAGPTPSAPSVPPQGSPATSQPPN 219

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  831 LHGLPLSEG--LQPYPAFPFPYLDTfmtvflPDPPVCPLLSPSflpcpflgatassaispsmssamsptldPPPSVTSQR 908
Cdd:pfam03154  220 QTQSTAAPHtlIQQTPTLHPQRLPS------PHPPLQPMTQPP----------------------------PPSQVSPQP 265

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  909 REEEKWEAQSE--GHPFITSRSSSPLQLNllqeemPRPSESPDQMRRNTCPQTEYQCVTGNNGSES-SPATTGALSTGSP 985
Cdd:pfam03154  266 LPQPSLHGQMPpmPHSLQTGPSHMQHPVP------PQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIhTPPSQSQLQSQQP 339

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217271987  986 PRENPSHPTASALSTGSPPMKNPSHPTASALSTGSPPmkNPSHPTASTLSMGLPPSrtPSHPTATVLSTGSPPSESP 1062
Cdd:pfam03154  340 PREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPP--HLSGPSPFQMNSNLPPP--PALKPLSSLSTHHPPSAHP 412
 
Name Accession Description Interval E-value
Period_C pfam12114
Period protein 2/3C-terminal region; This domain is found in eukaryotes. This domain is ...
 1082-1184 1.16e-25

Period protein 2/3C-terminal region; This domain is found in eukaryotes. This domain is typically between 164 to 200 amino acids in length. This domain is found associated with pfam08447.


Pssm-ID: 463464  Cd Length: 171  Bit Score: 104.79  E-value: 1.16e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987 1082 SVYSSKISQNGQQSQDVQKKETF-PNVAEEPIWRMIRQTPERILMTYQVPERVKEVVLKEDLEKLESMRQQQPQFSHGQK 1160
Cdd:pfam12114   68 SIDSSENNHKAKKTAEVGEEEHFiKCVLQDPIWLLMANTDDSVMMTYQIPSRDLETVLKEDREKLKAMQKMQPRFTEDQK 147

                           90       100
                   ....*....|....*....|....
gi 2217271987 1161 EELAKVYNWIQSQTVTQEIDIQAC 1184
Cdd:pfam12114  148 GELAEVHPWIQKGGLPAALDLSEC 171
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 284-376 1.80e-12

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 64.58  E-value: 1.80e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  284 FLEVDEKAVPLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLKYAGHPPFEhspIRFCTQNGDYIILDSSWSSFVNPW 363
Cdd:cd00130     14 ILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLSGGEPVTLE---VRLRRKDGSVIWVLVSLTPIRDEG 90

                           90
                   ....*....|...
gi 2217271987  364 SRKISFIIGRHKV 376
Cdd:cd00130     91 GEVIGLLGVVRDI 103
PAS_3 pfam08447
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 284-372 6.93e-12

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.


Pssm-ID: 430001 [Multi-domain]  Cd Length: 89  Bit Score: 62.74  E-value: 6.93e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  284 FLEVDEKAVPLLGYLPQDLIGT--SILSYLHPEDRSLMVAIHQKVLKYAGhpPFEHsPIRFCTQNGDYIILDSSWSSFVN 361
Cdd:pfam08447    1 IIYWSPRFEEILGYTPEELLGKgeSWLDLVHPDDRERVREALWEALKGGE--PYSG-EYRIRRKDGEYRWVEARARPIRD 77

                           90
                   ....*....|.
gi 2217271987  362 pWSRKISFIIG 372
Cdd:pfam08447   78 -ENGKPVRVIG 87
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 751-1062 3.83e-08

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 57.85  E-value: 3.83e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  751 LPEPPDSSSSNTGSgprrgAHQNAQPCCPSAASSPHTSSPTFPPAAMVPSQAPylvPAFPLPAATSPGREYAAPGTAPEG 830
Cdd:pfam03154  148 IPSPQDNESDSDSS-----AQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAA---TAGPTPSAPSVPPQGSPATSQPPN 219

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  831 LHGLPLSEG--LQPYPAFPFPYLDTfmtvflPDPPVCPLLSPSflpcpflgatassaispsmssamsptldPPPSVTSQR 908
Cdd:pfam03154  220 QTQSTAAPHtlIQQTPTLHPQRLPS------PHPPLQPMTQPP----------------------------PPSQVSPQP 265

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  909 REEEKWEAQSE--GHPFITSRSSSPLQLNllqeemPRPSESPDQMRRNTCPQTEYQCVTGNNGSES-SPATTGALSTGSP 985
Cdd:pfam03154  266 LPQPSLHGQMPpmPHSLQTGPSHMQHPVP------PQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIhTPPSQSQLQSQQP 339

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217271987  986 PRENPSHPTASALSTGSPPMKNPSHPTASALSTGSPPmkNPSHPTASTLSMGLPPSrtPSHPTATVLSTGSPPSESP 1062
Cdd:pfam03154  340 PREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPP--HLSGPSPFQMNSNLPPP--PALKPLSSLSTHHPPSAHP 412
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 284-328 1.25e-07

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


Pssm-ID: 214512  Cd Length: 67  Bit Score: 49.71  E-value: 1.25e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 2217271987   284 FLEVDEKAVPLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLK 328
Cdd:smart00091   23 ILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQEALQRLLS 67
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 748-1063 6.86e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 54.02  E-value: 6.86e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  748 RKKLPEPPDSSSSNTGSGPRRGAHQNAQPCCPSAASSPHTSSP-------------TFPPAAMVPSQAPYLVPAFPL-PA 813
Cdd:PHA03307    64 RFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPtppgpsspdppppTPPPASPPPSPAPDLSEMLRPvGS 143

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  814 ATSPGREYAAPGTAPEGLHGLPLSEGLQPYPAFPfpyldtfMTVFLPDPPVCPLLSPSFLPCPFLGATASSAISPSMSSA 893
Cdd:PHA03307   144 PGPPPAASPPAAGASPAAVASDAASSRQAALPLS-------SPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISAS 216

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  894 MsptldPPPSVTSQRREEEKWEAQSEGhpfiTSRSSSPLQLNLLQEEMPRPSESPdqmrrNTCPQTEYQCVTGNN-GSES 972
Cdd:PHA03307   217 A-----SSPAPAPGRSAADDAGASSSD----SSSSESSGCGWGPENECPLPRPAP-----ITLPTRIWEASGWNGpSSRP 282

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  973 SPATTGALSTGSPPRENPSHPTASALSTGSPPMKNPSHPTASALSTGSPPmKNPSHPTASTLSMGLPPSRTPSHPTATvl 1052
Cdd:PHA03307   283 GPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSS-SESSRGAAVSPGPSPSRSPSPSRPPPP-- 359

                          330
                   ....*....|.
gi 2217271987 1053 STGSPPSESPS 1063
Cdd:PHA03307   360 ADPSSPRKRPR 370
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 273-373 3.25e-03

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 41.64  E-value: 3.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  273 IFTTTHTPGcVFLEVDEKAVPLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLKYAGHPPFEHSPIrfcTQNGDYIIL 352
Cdd:COG5805    169 LICVIDTDG-RILFINESIERLFGAPREELIGKNLLELLHPCDKEEFKERIESITEVWQEFIIEREII---TKDGRIRYF 244

                           90       100
                   ....*....|....*....|..
gi 2217271987  353 DSSWSSFVNP-WSRKISFIIGR 373
Cdd:COG5805    245 EAVIVPLIDTdGSVKGILVILR 266
 
Name Accession Description Interval E-value
Period_C pfam12114
Period protein 2/3C-terminal region; This domain is found in eukaryotes. This domain is ...
 1082-1184 1.16e-25

Period protein 2/3C-terminal region; This domain is found in eukaryotes. This domain is typically between 164 to 200 amino acids in length. This domain is found associated with pfam08447.


Pssm-ID: 463464  Cd Length: 171  Bit Score: 104.79  E-value: 1.16e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987 1082 SVYSSKISQNGQQSQDVQKKETF-PNVAEEPIWRMIRQTPERILMTYQVPERVKEVVLKEDLEKLESMRQQQPQFSHGQK 1160
Cdd:pfam12114   68 SIDSSENNHKAKKTAEVGEEEHFiKCVLQDPIWLLMANTDDSVMMTYQIPSRDLETVLKEDREKLKAMQKMQPRFTEDQK 147

                           90       100
                   ....*....|....*....|....
gi 2217271987 1161 EELAKVYNWIQSQTVTQEIDIQAC 1184
Cdd:pfam12114  148 GELAEVHPWIQKGGLPAALDLSEC 171
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 284-376 1.80e-12

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 64.58  E-value: 1.80e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  284 FLEVDEKAVPLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLKYAGHPPFEhspIRFCTQNGDYIILDSSWSSFVNPW 363
Cdd:cd00130     14 ILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLSGGEPVTLE---VRLRRKDGSVIWVLVSLTPIRDEG 90

                           90
                   ....*....|...
gi 2217271987  364 SRKISFIIGRHKV 376
Cdd:cd00130     91 GEVIGLLGVVRDI 103
PAS_3 pfam08447
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 284-372 6.93e-12

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.


Pssm-ID: 430001 [Multi-domain]  Cd Length: 89  Bit Score: 62.74  E-value: 6.93e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  284 FLEVDEKAVPLLGYLPQDLIGT--SILSYLHPEDRSLMVAIHQKVLKYAGhpPFEHsPIRFCTQNGDYIILDSSWSSFVN 361
Cdd:pfam08447    1 IIYWSPRFEEILGYTPEELLGKgeSWLDLVHPDDRERVREALWEALKGGE--PYSG-EYRIRRKDGEYRWVEARARPIRD 77

                           90
                   ....*....|.
gi 2217271987  362 pWSRKISFIIG 372
Cdd:pfam08447   78 -ENGKPVRVIG 87
PAS_11 pfam14598
PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), ...
 274-376 3.38e-09

PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).


Pssm-ID: 464214 [Multi-domain]  Cd Length: 110  Bit Score: 55.76  E-value: 3.38e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  274 FTTTHTPGCVFLEVDEKAVPLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLKYAGHppfEHSPI-RFCTQNGDYIIL 352
Cdd:pfam14598    4 FTTRHDIDGKIISCDTRAPFSLGYEKDELVGRSIYDLVHPQDLRTAKSHLREIIQTRGR---ATSPSyRLRLRDGDFLSV 80

                           90       100
                   ....*....|....*....|....
gi 2217271987  353 DSSWSSFVNPWSRKISFIIGRHKV 376
Cdd:pfam14598   81 HTKSKLFLNQNSNQQPFIMCTHTI 104
PAS pfam00989
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 271-370 3.87e-09

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395786 [Multi-domain]  Cd Length: 113  Bit Score: 55.50  E-value: 3.87e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  271 KRIFTTTHTPGCV------FLEVDEKAVPLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLKyAGHPPFEHSpIRFCT 344
Cdd:pfam00989    4 RAILESLPDGIFVvdedgrILYVNAAAEELLGLSREEVIGKSLLDLIPEEDDAEVAELLRQALL-QGEESRGFE-VSFRV 81

                           90       100
                   ....*....|....*....|....*.
gi 2217271987  345 QNGDYIILDSSWSSFVNPWSRKISFI 370
Cdd:pfam00989   82 PDGRPRHVEVRASPVRDAGGEILGFL 107
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 751-1062 3.83e-08

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 57.85  E-value: 3.83e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  751 LPEPPDSSSSNTGSgprrgAHQNAQPCCPSAASSPHTSSPTFPPAAMVPSQAPylvPAFPLPAATSPGREYAAPGTAPEG 830
Cdd:pfam03154  148 IPSPQDNESDSDSS-----AQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAA---TAGPTPSAPSVPPQGSPATSQPPN 219

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  831 LHGLPLSEG--LQPYPAFPFPYLDTfmtvflPDPPVCPLLSPSflpcpflgatassaispsmssamsptldPPPSVTSQR 908
Cdd:pfam03154  220 QTQSTAAPHtlIQQTPTLHPQRLPS------PHPPLQPMTQPP----------------------------PPSQVSPQP 265

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  909 REEEKWEAQSE--GHPFITSRSSSPLQLNllqeemPRPSESPDQMRRNTCPQTEYQCVTGNNGSES-SPATTGALSTGSP 985
Cdd:pfam03154  266 LPQPSLHGQMPpmPHSLQTGPSHMQHPVP------PQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIhTPPSQSQLQSQQP 339

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217271987  986 PRENPSHPTASALSTGSPPMKNPSHPTASALSTGSPPmkNPSHPTASTLSMGLPPSrtPSHPTATVLSTGSPPSESP 1062
Cdd:pfam03154  340 PREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPP--HLSGPSPFQMNSNLPPP--PALKPLSSLSTHHPPSAHP 412
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 284-328 1.25e-07

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


Pssm-ID: 214512  Cd Length: 67  Bit Score: 49.71  E-value: 1.25e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 2217271987   284 FLEVDEKAVPLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLK 328
Cdd:smart00091   23 ILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQEALQRLLS 67
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 755-1065 2.13e-07

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 55.31  E-value: 2.13e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  755 PDSSSSNTGSGPRRGAHQNAQPCCPSAA--------SSPHTSSPTFPPAAMVP-SQAPYLVPAFPLPAATSPGREYAAPG 825
Cdd:pfam05109  466 PTVSTADVTSPTPAGTTSGASPVTPSPSprdngtesKAPDMTSPTSAVTTPTPnATSPTPAVTTPTPNATSPTLGKTSPT 545

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  826 TAPEglhgLPLSEGLQPYPAFPFPYLDTFMTVFLPDPPVCPLLSPS-FLPCPFLGATASSAISPSMS----SAMSPTLDP 900
Cdd:pfam05109  546 SAVT----TPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTpNATSPTVGETSPQANTTNHTlggtSSTPVVTSP 621

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  901 PPSVTSqrreeekweAQSEGHPFITSRSSSPLQLNLLQ-EEMPRPSESpDQMRRNTCPQTEYQCVTGNNGSESSPATTGA 979
Cdd:pfam05109  622 PKNATS---------AVTTGQHNITSSSTSSMSLRPSSiSETLSPSTS-DNSTSHMPLLTSAHPTGGENITQVTPASTST 691

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  980 --LSTGSP-PRenpshPTASALSTGSPPMKNPSHPTASALSTGSPPmKNPSHPTASTLSMGLPPSRTPSHPTATVLSTGS 1056
Cdd:pfam05109  692 hhVSTSSPaPR-----PGTTSQASGPGNSSTSTKPGEVNVTKGTPP-KNATSPQAPSGQKTAVPTVTSTGGKANSTTGGK 765


                   ....*....
gi 2217271987 1057 PPSESPSRT 1065
Cdd:pfam05109  766 HTTGHGART 774
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 748-1063 6.86e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 54.02  E-value: 6.86e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  748 RKKLPEPPDSSSSNTGSGPRRGAHQNAQPCCPSAASSPHTSSP-------------TFPPAAMVPSQAPYLVPAFPL-PA 813
Cdd:PHA03307    64 RFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPtppgpsspdppppTPPPASPPPSPAPDLSEMLRPvGS 143

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  814 ATSPGREYAAPGTAPEGLHGLPLSEGLQPYPAFPfpyldtfMTVFLPDPPVCPLLSPSFLPCPFLGATASSAISPSMSSA 893
Cdd:PHA03307   144 PGPPPAASPPAAGASPAAVASDAASSRQAALPLS-------SPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISAS 216

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  894 MsptldPPPSVTSQRREEEKWEAQSEGhpfiTSRSSSPLQLNLLQEEMPRPSESPdqmrrNTCPQTEYQCVTGNN-GSES 972
Cdd:PHA03307   217 A-----SSPAPAPGRSAADDAGASSSD----SSSSESSGCGWGPENECPLPRPAP-----ITLPTRIWEASGWNGpSSRP 282

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  973 SPATTGALSTGSPPRENPSHPTASALSTGSPPMKNPSHPTASALSTGSPPmKNPSHPTASTLSMGLPPSRTPSHPTATvl 1052
Cdd:PHA03307   283 GPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSS-SESSRGAAVSPGPSPSRSPSPSRPPPP-- 359

                          330
                   ....*....|.
gi 2217271987 1053 STGSPPSESPS 1063
Cdd:PHA03307   360 ADPSSPRKRPR 370
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 752-1064 3.19e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 51.71  E-value: 3.19e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  752 PEPPDSSSSNTGSGPRRGAHQNAQPCC-PSAASSPHTSSPTFPPAAMVPSQAPYLVPAFPL-PAATSPGREYAAPGTAPE 829
Cdd:PHA03307    80 PANESRSTPTWSLSTLAPASPAREGSPtPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPvGSPGPPPAASPPAAGASP 159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  830 GLHGLPLSEGLQPYPAFPfpyldtfMTVFLPDPPVCPLLSPSFLPCPFLGATASSAISPSMSSAMsptldPPPSVTSQRR 909
Cdd:PHA03307   160 AAVASDAASSRQAALPLS-------SPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASA-----SSPAPAPGRS 227

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  910 EEEKWEAQSEGhpfiTSRSSSPLQLNLLQEEMPRPSESPdqmrrNTCPQTEYQCVTGNN-GSESSPATTGALSTGSPPRE 988
Cdd:PHA03307   228 AADDAGASSSD----SSSSESSGCGWGPENECPLPRPAP-----ITLPTRIWEASGWNGpSSRPGPASSSSSPRERSPSP 298

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217271987  989 NPSHPTASALSTGSPPMKNPSHPTASALSTGSPpmknpSHPTAStlSMGLPPSRTPSHPTAtvLSTGSPPSESPSR 1064
Cdd:PHA03307   299 SPSSPGSGPAPSSPRASSSSSSSRESSSSSTSS-----SSESSR--GAAVSPGPSPSRSPS--PSRPPPPADPSSP 365
PHA03247 PHA03247
large tegument protein UL36; Provisional
 738-1063 3.56e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.86  E-value: 3.56e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  738 SAGCRKGKHKRKKLPEPPDSSSSNTGSGPRRGAHQNAQPCCPSAASSPHTSSPTFPPAAMVPSQAPYLVPAFPLPAATSP 817
Cdd:PHA03247  2656 PAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPAL 2735

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  818 GREYAAPGTaPEGlHGLPLSEGLQPYPAFPfpyldtfMTVFLPDPPVCPLLSPS-FLPCPflgATASSAISPSMSSAMSP 896
Cdd:PHA03247  2736 PAAPAPPAV-PAG-PATPGGPARPARPPTT-------AGPPAPAPPAAPAAGPPrRLTRP---AVASLSESRESLPSPWD 2803

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  897 TLDPPPSVTSQRREEEKWEAQSEGHPFITSRSSSPLQLNllqeemPRPSESPDQMRRNTCPQTEYQcvtgNNGSESSPAT 976
Cdd:PHA03247  2804 PADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPP------PGPPPPSLPLGGSVAPGGDVR----RRPPSRSPAA 2873

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  977 TGALSTGSP----PRENPSHPTASaLSTGSPPMKNPSHPTASALSTGSPPMKNPSHPTASTLSMGLPPSrtPSHPTATVL 1052
Cdd:PHA03247  2874 KPAAPARPPvrrlARPAVSRSTES-FALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQP--PLAPTTDPA 2950

                          330
                   ....*....|.
gi 2217271987 1053 STGSPPSESPS 1063
Cdd:PHA03247  2951 GAGEPSGAVPQ 2961
PHA03247 PHA03247
large tegument protein UL36; Provisional
 754-1062 4.55e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 4.55e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  754 PPDSSSSNTGSGPRRGAHQNAQPccpsAASSPHTSSPTFPPAAmvPSQAPYLVPAFPLPAATSPGREYAAPGTAPEGLHG 833
Cdd:PHA03247  2592 PPQSARPRAPVDDRGDPRGPAPP----SPLPPDTHAPDPPPPS--PSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPR 2665

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  834 LPLSEGLQPYPAFPfpyldtfmtvflPDPPVCPLLSPSFLPCPFLGatassaispsmssamsptlDPPPSvtsQRREEEK 913
Cdd:PHA03247  2666 RARRLGRAAQASSP------------PQRPRRRAARPTVGSLTSLA-------------------DPPPP---PPTPEPA 2711

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  914 WEAQSEGHPfitsrssSPLQLNLLQEEMPRPSESPdqmrrNTCPQTEYQCVTGNNGSESSPATTGALSTGSPPRENPSHP 993
Cdd:PHA03247  2712 PHALVSATP-------LPPGPAAARQASPALPAAP-----APPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGP 2779

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217271987  994 ----TASALSTGSPPMKNPSHPTASALSTGSPPMKNPSHPTASTLSMGLPPSRTPShPTATVLSTGSPPSESP 1062
Cdd:PHA03247  2780 prrlTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQ-PTAPPPPPGPPPPSLP 2851
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 752-1065 8.51e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 50.17  E-value: 8.51e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  752 PEPPDSSSSNTGSGPRRG-AHQNAQPCCPSAASSPHTSSPtFPPAAMVPSQAPYLVPAFPLPAATSPGREYAAPGTAPEG 830
Cdd:PHA03307   114 PDPPPPTPPPASPPPSPApDLSEMLRPVGSPGPPPAASPP-AAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAE 192

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  831 LHGLPLSEGLQPYPafpfPYLDTFMTVFLPDPPVCPLLSPSFLPCPFLGATASSAISPSMSSAMSPTLDPPPS---VTSQ 907
Cdd:PHA03307   193 PPPSTPPAAASPRP----PRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPApitLPTR 268

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  908 RREEEKWEAQSEGHPFITSRSSSPlqlnllqEEMPRPSESPDQMRRNTCPQTeyqcVTGNNGSESSPATTGALSTGSPPR 987
Cdd:PHA03307   269 IWEASGWNGPSSRPGPASSSSSPR-------ERSPSPSPSSPGSGPAPSSPR----ASSSSSSSRESSSSSTSSSSESSR 337

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217271987  988 ENPSHPtasalstGSPPMKNPSHPTASALSTGSPPMKN-PSHPTASTLSMGlPPSRTPSHPTATVLSTGSPPSESPSRT 1065
Cdd:PHA03307   338 GAAVSP-------GPSPSRSPSPSRPPPPADPSSPRKRpRPSRAPSSPAAS-AGRPTRRRARAAVAGRARRRDATGRFP 408
PHA03247 PHA03247
large tegument protein UL36; Provisional
 754-1060 8.55e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 8.55e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  754 PPDSSSSNTGSGPRRGAhQNAQPCCPSAASSPHTSSPTFPPAAMVPSQAPYLVPAFPLPAATSPgreyaAPGTAPEGLHG 833
Cdd:PHA03247  2742 PAVPAGPATPGGPARPA-RPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDP-----ADPPAAVLAPA 2815

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  834 LPLSEGLQPYPAFPFPyldtfmTVFLPDPPVCPllsPSFLPCPFlgATASSAISPSMSSAMSPTLDPPPSVTSQRREEEK 913
Cdd:PHA03247  2816 AALPPAASPAGPLPPP------TSAQPTAPPPP---PGPPPPSL--PLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVR 2884

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  914 WEAQSEghpfiTSRSSSPLQLNLLQEEMPRPSESPDQMRRNTCPQTEYQCVTGNNG---SESSPATTGALSTGSPPRENP 990
Cdd:PHA03247  2885 RLARPA-----VSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPpprPQPPLAPTTDPAGAGEPSGAV 2959

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217271987  991 SHPTASALSTGSPPMKN----PSHPTASALSTGSPPMKNPSHPTASTLSMGLPPSRTPSHPTATVLSTGSPPSE 1060
Cdd:PHA03247  2960 PQPWLGALVPGRVAVPRfrvpQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEETDPPPVSLKQTLWPPDD 3033
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 751-1063 4.24e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 47.84  E-value: 4.24e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  751 LPEPPDSSSSNTGSGPRRGAHQNAQPCCPSAASSP-HTSSPTFP-PAAMVPSQAPYLVPAFPLPAATSPGREYA-APGTA 827
Cdd:pfam03154  252 MTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPsHMQHPVPPqPFPLTPQSSQSQVPPGPSPAAPGQSQQRIhTPPSQ 331

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  828 PEGLHGLPLSEglQPYPAFPFPyldtfMTVFLPDP--PVCPLLSPSFLPCPflgatasSAISPSMSSAMSPTLDPPPSVt 905
Cdd:pfam03154  332 SQLQSQQPPRE--QPLPPAPLS-----MPHIKPPPttPIPQLPNPQSHKHP-------PHLSGPSPFQMNSNLPPPPAL- 396

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  906 sqrreeEKWEAQSEGHPfiTSRSSSPLQLNLLQEEMPRPSESPDQMrrntcpqTEYQCVTGnngSESSPATTGALSTGSP 985
Cdd:pfam03154  397 ------KPLSSLSTHHP--PSAHPPPLQLMPQSQQLPPPPAQPPVL-------TQSQSLPP---PAASHPPTSGLHQVPS 458

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  986 preNPSHPTASALSTGSPPMKNPSHPTASALSTGS---PPMKNP---SHPTASTLSMGLPPSRTPSHPTATVLSTGS--P 1057
Cdd:pfam03154  459 ---QSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPgiqPPSSASvssSGPVPAAVSCPLPPVQIKEEALDEAEEPESppP 535


                   ....*.
gi 2217271987 1058 PSESPS 1063
Cdd:pfam03154  536 PPRSPS 541
PHA03247 PHA03247
large tegument protein UL36; Provisional
 751-1063 6.68e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.63  E-value: 6.68e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  751 LPEPPDSSSSNTGSGPRRGAHQNAQPCCPSAASSP-------HTSSPTFPPAAMVPSQAPYLVPAFPLPAATSPGREYAA 823
Cdd:PHA03247  2624 PDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPgrvsrprRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPP 2703

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  824 PGTAPE-----GLHGLPLSEGLQPYPAFPFPYLDTFMTVFLPDPPVCPlLSPSFLPCPFLGATASSAISPSMSSAMSPTL 898
Cdd:PHA03247  2704 PPPTPEpaphaLVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATP-GGPARPARPPTTAGPPAPAPPAAPAAGPPRR 2782

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  899 DPPPSVTSQrrEEEKWEAQSEGHPFITSRSSSPLQLNLLQEEMPRPSESPDQMRRNTCPQTEYQCVTGNNGSESSPATTG 978
Cdd:PHA03247  2783 LTRPAVASL--SESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGG 2860

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  979 ALSTGSPPRENPSHPTAsalstgsppmknPSHPTASALStgSPPMKNPSHPTASTlSMGLPPSRTPSHPTATVLSTGSPP 1058
Cdd:PHA03247  2861 DVRRRPPSRSPAAKPAA------------PARPPVRRLA--RPAVSRSTESFALP-PDQPERPPQPQAPPPPQPQPQPPP 2925


                   ....*
gi 2217271987 1059 SESPS 1063
Cdd:PHA03247  2926 PPQPQ 2930
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 752-1063 5.34e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 44.37  E-value: 5.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  752 PEPPDSSSSNTGSGPRRGAHQNAQPCCPSAASSPHTSSPTFPPAAMVPSQAPYLVPAFPLP-------AATSPGREYAAP 824
Cdd:pfam03154  185 SPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPhpplqpmTQPPPPSQVSPQ 264

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  825 GTAPEGLHGL--PLSEGLQ--------PYPAFPFPYLDTFMTVFLPDPPVCPLLSPSflpcpflgatassaispsmssAM 894
Cdd:pfam03154  265 PLPQPSLHGQmpPMPHSLQtgpshmqhPVPPQPFPLTPQSSQSQVPPGPSPAAPGQS---------------------QQ 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  895 SPTLDPPPSVTSQRR--EEEKWEAQSEGHPFITSRSSSPLQLNLLQEEMPRPSE----SPDQMRRNTCPQTEYQ---CVT 965
Cdd:pfam03154  324 RIHTPPSQSQLQSQQppREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHlsgpSPFQMNSNLPPPPALKplsSLS 403

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  966 GNNGSESSPATTGALSTGSPPRENPSHPTASALSTGSPPmKNPSHPTASALSTGSPPMKNPSHPTASTLSMGLPPSRTPS 1045
Cdd:pfam03154  404 THHPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPP-PAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPP 482

                          330
                   ....*....|....*...
gi 2217271987 1046 HPTATVLSTGSPPSESPS 1063
Cdd:pfam03154  483 TSTSSAMPGIQPPSSASV 500
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 273-373 3.25e-03

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 41.64  E-value: 3.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  273 IFTTTHTPGcVFLEVDEKAVPLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLKYAGHPPFEHSPIrfcTQNGDYIIL 352
Cdd:COG5805    169 LICVIDTDG-RILFINESIERLFGAPREELIGKNLLELLHPCDKEEFKERIESITEVWQEFIIEREII---TKDGRIRYF 244

                           90       100
                   ....*....|....*....|..
gi 2217271987  353 DSSWSSFVNP-WSRKISFIIGR 373
Cdd:COG5805    245 EAVIVPLIDTdGSVKGILVILR 266
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 752-1062 3.49e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.70  E-value: 3.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  752 PEPPDSSSSNTGSGPRRGAHQNAQPCCPSAASSPHTSSPTFPPAAMVPSQAPYLVPAFPLPAATSPGREYAAPGTAPEGL 831
Cdd:PHA03307   129 SPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPR 208

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  832 HGLPLSEG-LQPYPAFP----FPYLDTFMTVFLPDPPVCPLLSPSFLPCPFLGATASSAISPSMSSAMSPTLDPPP--SV 904
Cdd:PHA03307   209 RSSPISASaSSPAPAPGrsaaDDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPasSS 288

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  905 TSQRREEEKWEAQSEGHPFITSRSSSPLQLNLLQEEMPrPSESPDQMRRNTCPQTeyqcvTGNNGSES-SPATTGALSTG 983
Cdd:PHA03307   289 SSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSS-SSTSSSSESSRGAAVS-----PGPSPSRSpSPSRPPPPADP 362

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217271987  984 SPPRENPshPTASALSTGSPPMKNPSHPTASALSTGSPPMKNPSHPtastlsmgLPPSRTPSHPTATVLSTGSPPSESP 1062
Cdd:PHA03307   363 SSPRKRP--RPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGR--------FPAGRPRPSPLDAGAASGAFYARYP 431
PHA03379 PHA03379
EBNA-3A; Provisional
 752-1062 9.07e-03

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 40.43  E-value: 9.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  752 PEPPDSSSSNTGSGPRRGAHQN-AQPCCPSAASSPHTSSPTfPPAAMVPSQAPYLVPAFPLPAATSPGREYAAPGTAPEG 830
Cdd:PHA03379   425 PEVPQSLETATSHGSAQVPEPPpVHDLEPGPLHDQHSMAPC-PVAQLPPGPLQDLEPGDQLPGVVQDGRPACAPVPAPAG 503

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  831 LHGLPLSEGLQPYPAFPF-PYLDTFMTV-FLPDP------PVCPLLSPSFLPCPflGATASSAISPSMSSAMSPTLDPPP 902
Cdd:PHA03379   504 PIVRPWEASLSQVPGVAFaPVMPQPMPVePVPVPtvalerPVCPAPPLIAMQGP--GETSGIVRVRERWRPAPWTPNPPR 581

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  903 SVTSQRREEEKWEAQSEGHPFITSRSSSPLQLNLL--QEEMPRPSEsPDQMRRNTCPQTEYQCVTGNNG----------- 969
Cdd:PHA03379   582 SPSQMSVRDRLARLRAEAQPYQASVEVQPPQLTQVspQQPMEYPLE-PEQQMFPGSPFSQVADVMRAGGvpamqpqyfdl 660

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271987  970 SESSPATTGALST-------GSPPR--ENPSH---PTASALSTGSP--------PMKNPSHPtASALSTGSPPMKNPSHP 1029
Cdd:PHA03379   661 PLQQPISQGAPLAplrasmgPVPPVpaTQPQYfdiPLTEPINQGASaahflpqqPMEGPLVP-ERWMFQGATLSQSVRPG 739

                          330       340       350
                   ....*....|....*....|....*....|...
gi 2217271987 1030 TASTLSMGLPPSRTPSHPTATVLSTGSPPSESP 1062
Cdd:PHA03379   740 VAQSQYFDLPLTQPINHGAPAAHFLHQPPMEGP 772
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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