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Conserved domains on  [gi|2217297356|ref|XP_047287301|]
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leucine-rich repeat-containing protein 9 isoform X6 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 17598810)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 871-1116 4.91e-25

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 104.48  E-value: 4.91e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  871 FRNVCNVNLQNNHLTSFSGLIYLPNVKVLCLNYNHIESImPRLKPQTHLTSRQLlyqkvpssgygqQG--ISKtnrdims 948
Cdd:cd21340      1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYL------------QNnqIEK------- 60

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  949 senlppimhslevlhlgyngICNliqlqLNRLRNLKFLFLQGNEISQVEGLDNLVVLQELVVDHNRIRS-----FN-DSA 1022
Cdd:cd21340     61 --------------------IEN-----LENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPPgekltFDpRSL 115

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356 1023 FAKPSSLLALHLEENRLRELGKLQSLVKLEKLFLGYNKIQDITELEklDVIST---LRELTVYGNPICRKMLHRHMLIFR 1099
Cdd:cd21340    116 AALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELL--DLLSSwpsLRELDLTGNPVCKKPKYRDKIILA 193

                          250
                   ....*....|....*..
gi 2217297356 1100 LPNLQMLDGSPVNSDDR 1116
Cdd:cd21340    194 SKSLEVLDGKEITDTER 210
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 633-821 9.69e-22

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 95.24  E-value: 9.69e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  633 HLHLSGNCYLKITALN---------LDGQHLFEITNLEKLENLKWASFSNNNLTKMEGLESCINLEELTLDGNCISKIEG 703
Cdd:cd21340      6 HLYLNDKNITKIDNLSlcknlkvlyLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEG 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  704 ISKMTKLTRLSINNNLLTGWEEHTFDNML------HLHSLSLENNRITSLSGLQKSFTLVELYISNNYIavnQEMHN--- 774
Cdd:cd21340     86 LENLTNLEELHIENQRLPPGEKLTFDPRSlaalsnSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQI---SDLEElld 162

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 2217297356  775 -LKGLCNLVILDMCGNIIIwNQENYRLFVIFHLPELKALDGIPIEPSE 821
Cdd:cd21340    163 lLSSWPSLRELDLTGNPVC-KKPKYRDKIILASKSLEVLDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
386-771 1.50e-16

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.44  E-value: 1.50e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  386 SLFSVFNNVILEESKKNPEVSVFSKDLKFDDEVIKMEPRIKARPKLISLDDKTILSLAKTSVYSHIVSLNLHGNSLSKLR 465
Cdd:COG4886     11 KLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLT 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  466 DLSKLTGLRKLNISFNEftcldDVYHLYNLEYLDASHNHVITL-EGFRGLMKLKHLDLSWNQLKKSGNEINMLckhtTSL 544
Cdd:COG4886     91 DLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPEPLGNL----TNL 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  545 LTLDIQHNpwqkpatlRLS----VIGRLKTLTHLNgvfiseeeataamkfIAGTRITQLSllrhsstkeerprilsiwps 620
Cdd:COG4886    162 KSLDLSNN--------QLTdlpeELGNLTNLKELD---------------LSNNQITDLP-------------------- 198

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  621 aKILTQVSKLGpHLHLSGNcylKITALNLdgqhlfEITNLEKLENLkwaSFSNNNLTKMEGLESCINLEELTLDGNCISK 700
Cdd:COG4886    199 -EPLGNLTNLE-ELDLSGN---QLTDLPE------PLANLTNLETL---DLSNNQLTDLPELGNLTNLEELDLSNNQLTD 264

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217297356  701 IEGISKMTKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRITSLSGLQKSFTLVELYISNNYIAVNQE 771
Cdd:COG4886    265 LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 871-1116 4.91e-25

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 104.48  E-value: 4.91e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  871 FRNVCNVNLQNNHLTSFSGLIYLPNVKVLCLNYNHIESImPRLKPQTHLTSRQLlyqkvpssgygqQG--ISKtnrdims 948
Cdd:cd21340      1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYL------------QNnqIEK------- 60

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  949 senlppimhslevlhlgyngICNliqlqLNRLRNLKFLFLQGNEISQVEGLDNLVVLQELVVDHNRIRS-----FN-DSA 1022
Cdd:cd21340     61 --------------------IEN-----LENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPPgekltFDpRSL 115

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356 1023 FAKPSSLLALHLEENRLRELGKLQSLVKLEKLFLGYNKIQDITELEklDVIST---LRELTVYGNPICRKMLHRHMLIFR 1099
Cdd:cd21340    116 AALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELL--DLLSSwpsLRELDLTGNPVCKKPKYRDKIILA 193

                          250
                   ....*....|....*..
gi 2217297356 1100 LPNLQMLDGSPVNSDDR 1116
Cdd:cd21340    194 SKSLEVLDGKEITDTER 210
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 633-821 9.69e-22

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 95.24  E-value: 9.69e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  633 HLHLSGNCYLKITALN---------LDGQHLFEITNLEKLENLKWASFSNNNLTKMEGLESCINLEELTLDGNCISKIEG 703
Cdd:cd21340      6 HLYLNDKNITKIDNLSlcknlkvlyLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEG 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  704 ISKMTKLTRLSINNNLLTGWEEHTFDNML------HLHSLSLENNRITSLSGLQKSFTLVELYISNNYIavnQEMHN--- 774
Cdd:cd21340     86 LENLTNLEELHIENQRLPPGEKLTFDPRSlaalsnSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQI---SDLEElld 162

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 2217297356  775 -LKGLCNLVILDMCGNIIIwNQENYRLFVIFHLPELKALDGIPIEPSE 821
Cdd:cd21340    163 lLSSWPSLRELDLTGNPVC-KKPKYRDKIILASKSLEVLDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
386-771 1.50e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.44  E-value: 1.50e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  386 SLFSVFNNVILEESKKNPEVSVFSKDLKFDDEVIKMEPRIKARPKLISLDDKTILSLAKTSVYSHIVSLNLHGNSLSKLR 465
Cdd:COG4886     11 KLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLT 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  466 DLSKLTGLRKLNISFNEftcldDVYHLYNLEYLDASHNHVITL-EGFRGLMKLKHLDLSWNQLKKSGNEINMLckhtTSL 544
Cdd:COG4886     91 DLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPEPLGNL----TNL 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  545 LTLDIQHNpwqkpatlRLS----VIGRLKTLTHLNgvfiseeeataamkfIAGTRITQLSllrhsstkeerprilsiwps 620
Cdd:COG4886    162 KSLDLSNN--------QLTdlpeELGNLTNLKELD---------------LSNNQITDLP-------------------- 198

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  621 aKILTQVSKLGpHLHLSGNcylKITALNLdgqhlfEITNLEKLENLkwaSFSNNNLTKMEGLESCINLEELTLDGNCISK 700
Cdd:COG4886    199 -EPLGNLTNLE-ELDLSGN---QLTDLPE------PLANLTNLETL---DLSNNQLTDLPELGNLTNLEELDLSNNQLTD 264

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217297356  701 IEGISKMTKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRITSLSGLQKSFTLVELYISNNYIAVNQE 771
Cdd:COG4886    265 LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
778-1132 3.89e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.29  E-value: 3.89e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  778 LCNLVILDMCGNIIIWNQENYRLFVIFHLPELKALDGIPIEPSETDSAKDLFGGRLTSDMIAERQGHSNFKQMQELNWTS 857
Cdd:COG4886      2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  858 SSIRTVDLIPVDQFRNVCNVNLQNNhltsfSGLIYLPNVKVLCLNYNHIESIMPRLKPQTHLTSrqlLYqkvpssgygqq 937
Cdd:COG4886     82 LSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLPEELANLTNLKE---LD----------- 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  938 gISKTN-RDIMSS-ENLPpimhSLEVLHLGYNGICNlIQLQLNRLRNLKFLFLQGNEISQV-EGLDNLVVLQELVVDHNR 1014
Cdd:COG4886    143 -LSNNQlTDLPEPlGNLT----NLKSLDLSNNQLTD-LPEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQ 216

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356 1015 IRSFNDSaFAKPSSLLALHLEENRLRELGKLQSLVKLEKLFLGYNKIQDITELEKLdviSTLRELTVYGNPICRKMLHRH 1094
Cdd:COG4886    217 LTDLPEP-LANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANL---TNLKTLDLSNNQLTDLKLKEL 292

                          330       340       350
                   ....*....|....*....|....*....|....*...
gi 2217297356 1095 MLIFRLPNLQMLDGSPVNSDDRAKAEFHLAELQAKKNS 1132
Cdd:COG4886    293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLL 330
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 449-583 3.73e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 70.20  E-value: 3.73e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  449 SHIVSLNLHGNSLSKLRDLSKLTGLRKLNISFNEFTCLDDVYHLYNLE------------------------------YL 498
Cdd:cd21340     46 TNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEelhienqrlppgekltfdprslaalsnslrVL 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  499 DASHNHVITLEGFRGLMKLKHLDLSWNQLkKSGNEINMLCKHTTSLLTLDIQHNPWQKPATLRLSVIGRLKTLTHLNGVF 578
Cdd:cd21340    126 NISGNNIDSLEPLAPLRNLEQLDASNNQI-SDLEELLDLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKE 204


                   ....*
gi 2217297356  579 ISEEE 583
Cdd:cd21340    205 ITDTE 209
LRR_9 pfam14580
Leucine-rich repeat;
696-840 3.87e-07

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 51.30  E-value: 3.87e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  696 NCISKIEGISKMTKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRITSLSGLQKsftlvelyisnnyiavnqeMHNL 775
Cdd:pfam14580   52 NEIRKLDGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGDLDP-------------------LASL 112

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217297356  776 KGLCNLVILDmcgNIIIwNQENYRLFVIFHLPELKALDGIPIEPSETDSAKDLFGGRLTSDMIAE 840
Cdd:pfam14580  113 KKLTFLSLLR---NPVT-NKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAEKMFRSKQGKQLAKE 173
LRR_9 pfam14580
Leucine-rich repeat;
988-1120 1.31e-06

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 49.76  E-value: 1.31e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  988 LQGNEISQVEGLDNLVVLQELVVDHNRIrsfndsafakpssllaLHLEENrlreLGklQSLVKLEKLFLGYNKIQDITEL 1067
Cdd:pfam14580   49 FSDNEIRKLDGFPLLRRLKTLLLNNNRI----------------CRIGEG----LG--EALPNLTELILTNNNLQELGDL 106

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2217297356 1068 EKLDVISTLRELTVYGNPICRKMLHRHMLIFRLPNLQMLDGSPVNSDDRAKAE 1120
Cdd:pfam14580  107 DPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAE 159
LRR_8 pfam13855
Leucine rich repeat;
471-527 2.54e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 2.54e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217297356  471 TGLRKLNISFNEFTCLDDV--YHLYNLEYLDASHNHVITLEG--FRGLMKLKHLDLSWNQL 527
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGafKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 871-1116 4.91e-25

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 104.48  E-value: 4.91e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  871 FRNVCNVNLQNNHLTSFSGLIYLPNVKVLCLNYNHIESImPRLKPQTHLTSRQLlyqkvpssgygqQG--ISKtnrdims 948
Cdd:cd21340      1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYL------------QNnqIEK------- 60

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  949 senlppimhslevlhlgyngICNliqlqLNRLRNLKFLFLQGNEISQVEGLDNLVVLQELVVDHNRIRS-----FN-DSA 1022
Cdd:cd21340     61 --------------------IEN-----LENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPPgekltFDpRSL 115

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356 1023 FAKPSSLLALHLEENRLRELGKLQSLVKLEKLFLGYNKIQDITELEklDVIST---LRELTVYGNPICRKMLHRHMLIFR 1099
Cdd:cd21340    116 AALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELL--DLLSSwpsLRELDLTGNPVCKKPKYRDKIILA 193

                          250
                   ....*....|....*..
gi 2217297356 1100 LPNLQMLDGSPVNSDDR 1116
Cdd:cd21340    194 SKSLEVLDGKEITDTER 210
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 633-821 9.69e-22

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 95.24  E-value: 9.69e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  633 HLHLSGNCYLKITALN---------LDGQHLFEITNLEKLENLKWASFSNNNLTKMEGLESCINLEELTLDGNCISKIEG 703
Cdd:cd21340      6 HLYLNDKNITKIDNLSlcknlkvlyLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEG 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  704 ISKMTKLTRLSINNNLLTGWEEHTFDNML------HLHSLSLENNRITSLSGLQKSFTLVELYISNNYIavnQEMHN--- 774
Cdd:cd21340     86 LENLTNLEELHIENQRLPPGEKLTFDPRSlaalsnSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQI---SDLEElld 162

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 2217297356  775 -LKGLCNLVILDMCGNIIIwNQENYRLFVIFHLPELKALDGIPIEPSE 821
Cdd:cd21340    163 lLSSWPSLRELDLTGNPVC-KKPKYRDKIILASKSLEVLDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
386-771 1.50e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.44  E-value: 1.50e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  386 SLFSVFNNVILEESKKNPEVSVFSKDLKFDDEVIKMEPRIKARPKLISLDDKTILSLAKTSVYSHIVSLNLHGNSLSKLR 465
Cdd:COG4886     11 KLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLT 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  466 DLSKLTGLRKLNISFNEftcldDVYHLYNLEYLDASHNHVITL-EGFRGLMKLKHLDLSWNQLKKSGNEINMLckhtTSL 544
Cdd:COG4886     91 DLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPEPLGNL----TNL 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  545 LTLDIQHNpwqkpatlRLS----VIGRLKTLTHLNgvfiseeeataamkfIAGTRITQLSllrhsstkeerprilsiwps 620
Cdd:COG4886    162 KSLDLSNN--------QLTdlpeELGNLTNLKELD---------------LSNNQITDLP-------------------- 198

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  621 aKILTQVSKLGpHLHLSGNcylKITALNLdgqhlfEITNLEKLENLkwaSFSNNNLTKMEGLESCINLEELTLDGNCISK 700
Cdd:COG4886    199 -EPLGNLTNLE-ELDLSGN---QLTDLPE------PLANLTNLETL---DLSNNQLTDLPELGNLTNLEELDLSNNQLTD 264

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217297356  701 IEGISKMTKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRITSLSGLQKSFTLVELYISNNYIAVNQE 771
Cdd:COG4886    265 LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
778-1132 3.89e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.29  E-value: 3.89e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  778 LCNLVILDMCGNIIIWNQENYRLFVIFHLPELKALDGIPIEPSETDSAKDLFGGRLTSDMIAERQGHSNFKQMQELNWTS 857
Cdd:COG4886      2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  858 SSIRTVDLIPVDQFRNVCNVNLQNNhltsfSGLIYLPNVKVLCLNYNHIESIMPRLKPQTHLTSrqlLYqkvpssgygqq 937
Cdd:COG4886     82 LSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLPEELANLTNLKE---LD----------- 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  938 gISKTN-RDIMSS-ENLPpimhSLEVLHLGYNGICNlIQLQLNRLRNLKFLFLQGNEISQV-EGLDNLVVLQELVVDHNR 1014
Cdd:COG4886    143 -LSNNQlTDLPEPlGNLT----NLKSLDLSNNQLTD-LPEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQ 216

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356 1015 IRSFNDSaFAKPSSLLALHLEENRLRELGKLQSLVKLEKLFLGYNKIQDITELEKLdviSTLRELTVYGNPICRKMLHRH 1094
Cdd:COG4886    217 LTDLPEP-LANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANL---TNLKTLDLSNNQLTDLKLKEL 292

                          330       340       350
                   ....*....|....*....|....*....|....*...
gi 2217297356 1095 MLIFRLPNLQMLDGSPVNSDDRAKAEFHLAELQAKKNS 1132
Cdd:COG4886    293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLL 330
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 449-583 3.73e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 70.20  E-value: 3.73e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  449 SHIVSLNLHGNSLSKLRDLSKLTGLRKLNISFNEFTCLDDVYHLYNLE------------------------------YL 498
Cdd:cd21340     46 TNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEelhienqrlppgekltfdprslaalsnslrVL 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  499 DASHNHVITLEGFRGLMKLKHLDLSWNQLkKSGNEINMLCKHTTSLLTLDIQHNPWQKPATLRLSVIGRLKTLTHLNGVF 578
Cdd:cd21340    126 NISGNNIDSLEPLAPLRNLEQLDASNNQI-SDLEELLDLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKE 204


                   ....*
gi 2217297356  579 ISEEE 583
Cdd:cd21340    205 ITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
867-1086 4.01e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.41  E-value: 4.01e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  867 PVDQFRNVCNVNLQNNHLTSFSGLI-YLPNVKVLCLNYNHIESIMPRLKPQTHLTSRQLLYQKVPSSGYGQQGISKTNRD 945
Cdd:COG4886    108 ELSNLTNLESLDLSGNQLTDLPEELaNLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKEL 187

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  946 IMSS---ENLPPI---MHSLEVLHLGYNGICNLiQLQLNRLRNLKFLFLQGNEISQVEGLDNLVVLQELVVDHNRIRSFN 1019
Cdd:COG4886    188 DLSNnqiTDLPEPlgnLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP 266

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217297356 1020 DSafAKPSSLLALHLEENRLRE--LGKLQSLVKLEKLFLGYNKIQDITELEKLDVISTLRELTVYGNPI 1086
Cdd:COG4886    267 PL--ANLTNLKTLDLSNNQLTDlkLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGL 333
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
449-761 5.90e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.03  E-value: 5.90e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  449 SHIVSLNLHGNSLSKL-RDLSKLTGLRKLNISFNEFTCL-DDVYHLYNLEYLDASHNHVITL-EGFRGLMKLKHLDLSWN 525
Cdd:COG4886    113 TNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNN 192

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  526 QLKKSGNEINMLckhtTSLLTLDIQHNpwqkpatlRLS----VIGRLKTLTHLNgvfiseeeataamkfIAGTRITQLSL 601
Cdd:COG4886    193 QITDLPEPLGNL----TNLEELDLSGN--------QLTdlpePLANLTNLETLD---------------LSNNQLTDLPE 245

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  602 LRHSSTKEErpriLSIwpSAKILTQVSKLGP-----HLHLSGNcylKITALNLDGQHLFEITNLEKLENLKWASFSNNNL 676
Cdd:COG4886    246 LGNLTNLEE----LDL--SNNQLTDLPPLANltnlkTLDLSNN---QLTDLKLKELELLLGLNSLLLLLLLLNLLELLIL 316

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  677 TKMEGLESCINLEELTLDGNCISKIEGISKMTKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRITSLSGLQKSFTL 756
Cdd:COG4886    317 LLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTT 396


                   ....*
gi 2217297356  757 VELYI 761
Cdd:COG4886    397 TAGVL 401
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
453-650 1.19e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.87  E-value: 1.19e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  453 SLNLHGNSLSKL-RDLSKLTGLRKLNISFNEFTCLDDVYHLYNLEYLDASHNHVITLEGFRGLMKLKHLDLSWNQLKKSG 531
Cdd:COG4886    209 ELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLK 288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  532 NEINMLCKHTTSLLTLDIQHNPWQKPATLRLSVIGRLKTLTHLNGVFISEEEATAAMKFIAGTRITQLSLLRHSSTKEER 611
Cdd:COG4886    289 LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLT 368

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 2217297356  612 PRILSIWPSAKILTQVSKLGPHLHLSGNCYLKITALNLD 650
Cdd:COG4886    369 LGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLAL 407
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
685-1068 3.14e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.64  E-value: 3.14e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  685 CINLEELTLDGNCISKIEGISKMTKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRITSLSGLQKSFTLVELYISNN 764
Cdd:COG4886      2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  765 YIAVNQEMHNLKGLCNLVILDMCGNIIIwnqenyrlfviFHLPELKALDgipiepsetdsakdLFGGRLTS--DMIAerq 842
Cdd:COG4886     82 LSLLLLGLTDLGDLTNLTELDLSGNEEL-----------SNLTNLESLD--------------LSGNQLTDlpEELA--- 133

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  843 ghsNFKQMQELNWTSSSIRTVDLiPVDQFRNVCNVNLQNNHLTSFS-GLIYLPNVKVLCLNYNHIESIMPRLkpqTHLTS 921
Cdd:COG4886    134 ---NLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPeELGNLTNLKELDLSNNQITDLPEPL---GNLTN 206

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  922 RQLLYqkvpssgygqqgISKTN-RDImsSENLPPiMHSLEVLHLGYNGICNLIQLQlnRLRNLKFLFLQGNEISQVEGLD 1000
Cdd:COG4886    207 LEELD------------LSGNQlTDL--PEPLAN-LTNLETLDLSNNQLTDLPELG--NLTNLEELDLSNNQLTDLPPLA 269

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217297356 1001 NLVVLQELVVDHNRIRSFNDSAFAKPSSLLALHLEENRLRELGKLQSLVKLEKLFLGYNKIQDITELE 1068
Cdd:COG4886    270 NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTL 337
LRR_9 pfam14580
Leucine-rich repeat;
696-840 3.87e-07

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 51.30  E-value: 3.87e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  696 NCISKIEGISKMTKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRITSLSGLQKsftlvelyisnnyiavnqeMHNL 775
Cdd:pfam14580   52 NEIRKLDGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGDLDP-------------------LASL 112

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217297356  776 KGLCNLVILDmcgNIIIwNQENYRLFVIFHLPELKALDGIPIEPSETDSAKDLFGGRLTSDMIAE 840
Cdd:pfam14580  113 KKLTFLSLLR---NPVT-NKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAEKMFRSKQGKQLAKE 173
LRR_9 pfam14580
Leucine-rich repeat;
988-1120 1.31e-06

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 49.76  E-value: 1.31e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  988 LQGNEISQVEGLDNLVVLQELVVDHNRIrsfndsafakpssllaLHLEENrlreLGklQSLVKLEKLFLGYNKIQDITEL 1067
Cdd:pfam14580   49 FSDNEIRKLDGFPLLRRLKTLLLNNNRI----------------CRIGEG----LG--EALPNLTELILTNNNLQELGDL 106

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2217297356 1068 EKLDVISTLRELTVYGNPICRKMLHRHMLIFRLPNLQMLDGSPVNSDDRAKAE 1120
Cdd:pfam14580  107 DPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAE 159
LRR_8 pfam13855
Leucine rich repeat;
1005-1061 1.44e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 1.44e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217297356 1005 LQELVVDHNRIRSFNDSAFAKPSSLLALHLEENRLRELGK--LQSLVKLEKLFLGYNKI 1061
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
471-527 2.54e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 2.54e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217297356  471 TGLRKLNISFNEFTCLDDV--YHLYNLEYLDASHNHVITLEG--FRGLMKLKHLDLSWNQL 527
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGafKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
708-766 6.36e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 6.36e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217297356  708 TKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRITSLSGlqKSFT----LVELYISNNYI 766
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSP--GAFSglpsLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
687-744 6.42e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 6.42e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  687 NLEELTLDGNCISKIEGIS--KMTKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRI 744
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAfkGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
636-1115 1.07e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.08  E-value: 1.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  636 LSGNCYLKITALNLDGQHLFEITNLEKLENLKWASFSNNNltkmeGLESCINLEELTLDGNCISKI-EGISKMTKLTRLS 714
Cdd:COG4886     68 LLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLpEELANLTNLKELD 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  715 INNNLLTGWEEhTFDNMLHLHSLSLENNRITSLS-GLQKSFTLVELYISNNYIavnqemhnlkglcnlvildmcgniiiw 793
Cdd:COG4886    143 LSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPeELGNLTNLKELDLSNNQI--------------------------- 194

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  794 nqenyrlfvifhlpelkaldgipiepseTDSAKDLfggrltsdmiaerqghSNFKQMQELNwtsssirtvdlipvdqfrn 873
Cdd:COG4886    195 ----------------------------TDLPEPL----------------GNLTNLEELD------------------- 211

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  874 vcnvnLQNNHLTSFS-GLIYLPNVKVLCLNYNHIESImPRLKpqthltsrqllyqkvpssgygqqgisktnrdimsseNL 952
Cdd:COG4886    212 -----LSGNQLTDLPePLANLTNLETLDLSNNQLTDL-PELG------------------------------------NL 249

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  953 PpimhSLEVLHLGYNGICNLiqLQLNRLRNLKFLFLQGNEIS-----QVEGLDNLVVLQELVVDHNRIRSFNDSAFAKPS 1027
Cdd:COG4886    250 T----NLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTdlklkELELLLGLNSLLLLLLLLNLLELLILLLLLTTL 323

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356 1028 SLLALHLEENRLRELGKLQSLVKLEKLFLGYNKIQDITELEKLDVISTLRELTVYGNPICRKMLHRHMLIFRLPNLQMLD 1107
Cdd:COG4886    324 LLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLL 403


                   ....*...
gi 2217297356 1108 GSPVNSDD 1115
Cdd:COG4886    404 TLALLDAV 411
LRR_8 pfam13855
Leucine rich repeat;
449-505 1.45e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 1.45e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217297356  449 SHIVSLNLHGNSLSKLRD--LSKLTGLRKLNISFNEFTCLDDV--YHLYNLEYLDASHNHV 505
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGafSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
958-1015 8.53e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 8.53e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217297356  958 SLEVLHLGYNGICNLIQLQLNRLRNLKFLFLQGNEISQVEG--LDNLVVLQELVVDHNRI 1015
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 687-718 4.13e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 4.13e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2217297356  687 NLEELTLDGNCISKIEGISKMTKLTRLSINNN 718
Cdd:pfam12799    2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 665-706 5.77e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 5.77e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2217297356  665 NLKWASFSNNNLTKMEGLESCINLEELTLDGN-CISKIEGISK 706
Cdd:pfam12799    2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRR_8 pfam13855
Leucine rich repeat;
981-1039 6.61e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 6.61e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217297356  981 RNLKFLFLQGNEISQVEG--LDNLVVLQELVVDHNRIRSFNDSAFAKPSSLLALHLEENRL 1039
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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