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Conserved domains on  [gi|2217296489|ref|XP_047286971|]
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leucine-rich repeat-containing protein 74A isoform X6 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1006001)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 49-223 2.57e-29

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 114.50  E-value: 2.57e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296489  49 LMGVVPVSYFIRNMEESYVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNN 128
Cdd:COG5238   167 LLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNN 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296489 129 HLGLEGARIISDFFERNSSsIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSL 208
Cdd:COG5238   247 QIGDEGVIALAEALKNNTT-VETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTL 325

                         170
                  ....*....|....*
gi 2217296489 209 DLSWNNFHTRGAVAL 223
Cdd:COG5238   326 NLAYNGIGAQGAIAL 340
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 49-223 2.57e-29

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 114.50  E-value: 2.57e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296489  49 LMGVVPVSYFIRNMEESYVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNN 128
Cdd:COG5238   167 LLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNN 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296489 129 HLGLEGARIISDFFERNSSsIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSL 208
Cdd:COG5238   247 QIGDEGVIALAEALKNNTT-VETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTL 325

                         170
                  ....*....|....*
gi 2217296489 209 DLSWNNFHTRGAVAL 223
Cdd:COG5238   326 NLAYNGIGAQGAIAL 340
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 69-232 1.79e-19

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 85.87  E-value: 1.79e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296489  69 LNHHGLGPRGTKAIAIALVSN-MAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFeRNSS 147
Cdd:cd00116   115 LNNNGLGDRGLRLLAKGLKDLpPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGL-KANC 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296489 148 SIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHL-GQMLAINVGLTSLDLSWNNFHTRGAVALCNG 226
Cdd:cd00116   194 NLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALaSALLSPNISLLTLSLSCNDITDDGAKDLAEV 273


                  ....*.
gi 2217296489 227 LRGKSS 232
Cdd:cd00116   274 LAEKES 279
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 49-223 2.57e-29

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 114.50  E-value: 2.57e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296489  49 LMGVVPVSYFIRNMEESYVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNN 128
Cdd:COG5238   167 LLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNN 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296489 129 HLGLEGARIISDFFERNSSsIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSL 208
Cdd:COG5238   247 QIGDEGVIALAEALKNNTT-VETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTL 325

                         170
                  ....*....|....*
gi 2217296489 209 DLSWNNFHTRGAVAL 223
Cdd:COG5238   326 NLAYNGIGAQGAIAL 340
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 74-229 1.43e-26

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 107.18  E-value: 1.43e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296489  74 LGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFERNSSsIWSLE 153
Cdd:COG5238   248 IGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKT-LHTLN 326

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217296489 154 LSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRG 229
Cdd:COG5238   327 LAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQT 402
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 73-232 4.65e-26

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 105.64  E-value: 4.65e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296489  73 GLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFERNSSsIWSL 152
Cdd:COG5238   219 PIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTT-LTSL 297

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296489 153 ELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGKSS 232
Cdd:COG5238   298 DLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTT 377
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 67-213 4.04e-23

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 97.55  E-value: 4.04e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296489  67 VNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFERNS 146
Cdd:COG5238   269 LYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENT 348

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217296489 147 SsIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINvGLTSLDLSWN 213
Cdd:COG5238   349 T-LHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTN-RLHTLILDGN 413
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 69-232 1.79e-19

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 85.87  E-value: 1.79e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296489  69 LNHHGLGPRGTKAIAIALVSN-MAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFeRNSS 147
Cdd:cd00116   115 LNNNGLGDRGLRLLAKGLKDLpPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGL-KANC 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296489 148 SIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHL-GQMLAINVGLTSLDLSWNNFHTRGAVALCNG 226
Cdd:cd00116   194 NLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALaSALLSPNISLLTLSLSCNDITDDGAKDLAEV 273


                  ....*.
gi 2217296489 227 LRGKSS 232
Cdd:cd00116   274 LAEKES 279
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 58-200 1.03e-18

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 83.94  E-value: 1.03e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296489  58 FIRNMEEsyVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARI 137
Cdd:cd00116   163 ANRDLKE--LNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAA 240

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217296489 138 ISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLA 200
Cdd:cd00116   241 LASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLL 303
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 69-228 1.65e-18

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 83.17  E-value: 1.65e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296489  69 LNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVlSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFERNSSS 148
Cdd:cd00116    60 LNETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGC-GVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPA 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296489 149 IWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLsWNNFHTR-GAVALCNGL 227
Cdd:cd00116   139 LEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDL-NNNGLTDeGASALAETL 217


                  .
gi 2217296489 228 R 228
Cdd:cd00116   218 A 218
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 82-232 7.86e-16

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 76.37  E-value: 7.86e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296489  82 IAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQE--NYYLQEMNISNNHLGLEGARIISDFFERNSSsIWSLELSGNDF 159
Cdd:COG5238   142 NLIQVLKDPLGGNAVHLLGLAARLGLLAAISMAKAlqNNSVETVYLGCNQIGDEGIEELAEALTQNTT-VTTLWLKRNPI 220

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217296489 160 KEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGKSS 232
Cdd:COG5238   221 GDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTT 293
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 69-231 3.15e-15

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 73.93  E-value: 3.15e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296489  69 LNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFERNSSs 148
Cdd:cd00116   144 LGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKS- 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296489 149 IWSLELSGNDFKEDSAALLCQAL-STNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGL 227
Cdd:cd00116   223 LEVLNLGDNNLTDAGAAALASALlSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESL 302


                  ....
gi 2217296489 228 RGKS 231
Cdd:cd00116   303 LEPG 306
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 67-171 4.38e-11

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 62.50  E-value: 4.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296489  67 VNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFERNs 146
Cdd:COG5238   325 LNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTN- 403

                          90       100
                  ....*....|....*....|....*
gi 2217296489 147 sSIWSLELSGNDFKEDSAALLCQAL 171
Cdd:COG5238   404 -RLHTLILDGNLIGAEAQQRLEQLL 427
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 84-232 6.69e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 52.74  E-value: 6.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296489  84 IALVSNMAVtkLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLG--LEGARIISDFFeRNSSSIWSLELSGNDFKE 161
Cdd:cd00116    19 LPKLLCLQV--LRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGL-TKGCGLQELDLSDNALGP 95

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217296489 162 DSAALLcQALSTNYQIKKLDLSHNQFSDVGGEHLG---QMLAINvgLTSLDLSWNNFHTRGAVALCNGLRGKSS 232
Cdd:cd00116    96 DGCGVL-ESLLRSSSLQELKLNNNGLGDRGLRLLAkglKDLPPA--LEKLVLGRNRLEGASCEALAKALRANRD 166
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
63-215 5.07e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.07  E-value: 5.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296489  63 EESYVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIisdff 142
Cdd:COG4886    58 RDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEEL----- 132

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217296489 143 eRNSSSIWSLELSGNDFKEdsaalLCQALSTNYQIKKLDLSHNQFSDVgGEHLGQMlainVGLTSLDLSWNNF 215
Cdd:COG4886   133 -ANLTNLKELDLSNNQLTD-----LPEPLGNLTNLKSLDLSNNQLTDL-PEELGNL----TNLKELDLSNNQI 194
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 93-213 8.43e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 8.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296489  93 TKLELEDNCImeegvlSLVEMLQENYYLQEMNISNNHLGlEGARIISDffernSSSIWS-------LELSGN--DFKEDS 163
Cdd:cd21340    71 KKLYLGGNRI------SVVEGLENLTNLEELHIENQRLP-PGEKLTFD-----PRSLAAlsnslrvLNISGNniDSLEPL 138

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2217296489 164 AALlcqalstnYQIKKLDLSHNQFSDVggEHLGQMLAINVGLTSLDLSWN 213
Cdd:cd21340   139 APL--------RNLEQLDASNNQISDL--EELLDLLSSWPSLRELDLTGN 178
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
93-217 1.00e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.92  E-value: 1.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296489  93 TKLELEDNCIMeegvlSLVEMLQENYYLQEMNISNNHLglegaRIISDFFErNSSSIWSLELSGNDFKEDSAALlcQALS 172
Cdd:COG4886   139 KELDLSNNQLT-----DLPEPLGNLTNLKSLDLSNNQL-----TDLPEELG-NLTNLKELDLSNNQITDLPEPL--GNLT 205

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2217296489 173 tnyQIKKLDLSHNQFSDVGGEhLGQMlainVGLTSLDLSWNNFHT 217
Cdd:COG4886   206 ---NLEELDLSGNQLTDLPEP-LANL----TNLETLDLSNNQLTD 242
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
93-217 4.09e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 38.38  E-value: 4.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296489  93 TKLELEDNcimeeGVLSLVEMLQENYYLQEMNISNNHLglegaRIISDFFeRNSSSIWSLELSGNDFKEdsaalLCQALS 172
Cdd:COG4886   116 ESLDLSGN-----QLTDLPEELANLTNLKELDLSNNQL-----TDLPEPL-GNLTNLKSLDLSNNQLTD-----LPEELG 179

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2217296489 173 TNYQIKKLDLSHNQFSDVGGEhLGQMlainVGLTSLDLSWNNFHT 217
Cdd:COG4886   180 NLTNLKELDLSNNQITDLPEP-LGNL----TNLEELDLSGNQLTD 219
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
93-215 5.25e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 37.99  E-value: 5.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296489  93 TKLELEDNCIMEegvlsLVEMLQENYYLQEMNISNNHLglegaRIISDFFErNSSSIWSLELSGNDFKEdsaallCQALS 172
Cdd:COG4886   185 KELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQL-----TDLPEPLA-NLTNLETLDLSNNQLTD------LPELG 247

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2217296489 173 TNYQIKKLDLSHNQFSDVGgeHLGQMlainVGLTSLDLSWNNF 215
Cdd:COG4886   248 NLTNLEELDLSNNQLTDLP--PLANL----TNLKTLDLSNNQL 284
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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