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Conserved domains on  [gi|2217370873|ref|XP_047277349|]
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glutamate-rich protein 1 isoform X1 [Homo sapiens]

Protein Classification

ICP22 family protein( domain architecture ID 708738)

ICP22 family protein similar to Herpesvirus saimiri transcriptional regulator ICP22 homolog (also known as immediate-early protein) that regulates the transcription of alphaherpesviruses and their host genes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03169 super family cl27451
hypothetical protein; Provisional
 191-335 7.24e-06

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PHA03169:

Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 48.81  E-value: 7.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873 191 QPEDSSNEGEGVGEACEEDGVDTSEEDptlAGEEDVKDTREEDGADASEEdltrARQEEGADASEEDPTPAGEEDVKDAR 270
Cdd:PHA03169   47 APPAPTTSGPQVRAVAEQGHRQTESDT---ETAEESRHGEKEERGQGGPS----GSGSESVGSPTPSPSGSAEELASGLS 119

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217370873 271 EEDGVDTIEEDLTRAGEEDGKDTREEDGADASEEDPTWAGEEEGADSGEEDGADASEEDDTITNE 335
Cdd:PHA03169  120 PENTSGSSPESPASHSPPPSPPSHPGPHEPAPPESHNPSPNQQPSSFLQPSHEDSPEEPEPPTSE 184
 
Name Accession Description Interval E-value
PHA03169 PHA03169
hypothetical protein; Provisional
 191-335 7.24e-06

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 48.81  E-value: 7.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873 191 QPEDSSNEGEGVGEACEEDGVDTSEEDptlAGEEDVKDTREEDGADASEEdltrARQEEGADASEEDPTPAGEEDVKDAR 270
Cdd:PHA03169   47 APPAPTTSGPQVRAVAEQGHRQTESDT---ETAEESRHGEKEERGQGGPS----GSGSESVGSPTPSPSGSAEELASGLS 119

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217370873 271 EEDGVDTIEEDLTRAGEEDGKDTREEDGADASEEDPTWAGEEEGADSGEEDGADASEEDDTITNE 335
Cdd:PHA03169  120 PENTSGSSPESPASHSPPPSPPSHPGPHEPAPPESHNPSPNQQPSSFLQPSHEDSPEEPEPPTSE 184
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 132-330 5.84e-05

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 46.53  E-value: 5.84e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873  132 EQAELEKQQSLLQEKSQRQHTDGTTISKNKKRKLKKKQQIKRKKAAGLAAKAAGVSFMYQPEDSSNEGEGVGEAcEEDGV 211
Cdd:TIGR00927  661 EESGGEAEQEGETETKGENESEGEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEHEGETEAEGTEDEGEIET-GEEGE 739

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873  212 DTSEEDPTLA---GEEDVKDTREEDGADASEEDLTRARQEEGADASEEDPTPAGEEDVKDAREEDGVDTIEEDL------ 282
Cdd:TIGR00927  740 EVEDEGEGEAegkHEVETEGDRKETEHEGETEAEGKEDEDEGEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKDehegqs 819

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217370873  283 -TRAGEEDGKDTREEDGADASEEDPTWAGEE--------EGADSGEEDGADASEEDD 330
Cdd:TIGR00927  820 eTQADDTEVKDETGEQELNAENQGEAKQDEKgvdggggsDGGDSEEEEEEEEEEEEE 876
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 251-331 3.05e-04

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 43.63  E-value: 3.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873 251 ADASEEDPTPAGEEDVKDAREEDGvdtiEEDLTRAGEEDGKDTREEDGADASEEDPTwAGEEEGADSGEEDGADASEEDD 330
Cdd:COG4547   208 AEELGEDEDEEDEDDEDDSGEQEE----DEEDGEDEDEESDEGAEAEDAEASGDDAE-EGESEAAEAESDEMAEEAEGED 282


                  .
gi 2217370873 331 T 331
Cdd:COG4547   283 S 283
TFIIF_alpha pfam05793
Transcription initiation factor IIF, alpha subunit (TFIIF-alpha); Transcription initiation ...
 193-336 2.63e-03

Transcription initiation factor IIF, alpha subunit (TFIIF-alpha); Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) or RNA polymerase II-associating protein 74 (RAP74) is the large subunit of transcription factor IIF (TFIIF), which is essential for accurate initiation and stimulates elongation by RNA polymerase II.


Pssm-ID: 310411 [Multi-domain]  Cd Length: 528  Bit Score: 40.70  E-value: 2.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873 193 EDSSNEGEGVGEACEEDGVDTSEEDPTLAGEEDVKDTREEDGADASEEDltRARQEEGADASEEDPTPAGEEDVKDAREE 272
Cdd:pfam05793 197 EETEGEKGGGGRGKDLKIKDLEGDDEDDGDESDKGGEDGDEEKKKKKKK--KLAKNKKKLDDDKKKKRGGDDDAFEYDSD 274

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217370873 273 DGVD-TIEEDLTRAGEEDGKDTREEDGADASEEDPtwAGEEEGADSGEEDGADASEEDDTITNEK 336
Cdd:pfam05793 275 DGDDeGREEDYISDSSASGNDPEEREDKLSPEEPA--KGEIEQSDDSEESEEEKNEEEGKLSKKG 337
 
Name Accession Description Interval E-value
PHA03169 PHA03169
hypothetical protein; Provisional
 191-335 7.24e-06

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 48.81  E-value: 7.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873 191 QPEDSSNEGEGVGEACEEDGVDTSEEDptlAGEEDVKDTREEDGADASEEdltrARQEEGADASEEDPTPAGEEDVKDAR 270
Cdd:PHA03169   47 APPAPTTSGPQVRAVAEQGHRQTESDT---ETAEESRHGEKEERGQGGPS----GSGSESVGSPTPSPSGSAEELASGLS 119

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217370873 271 EEDGVDTIEEDLTRAGEEDGKDTREEDGADASEEDPTWAGEEEGADSGEEDGADASEEDDTITNE 335
Cdd:PHA03169  120 PENTSGSSPESPASHSPPPSPPSHPGPHEPAPPESHNPSPNQQPSSFLQPSHEDSPEEPEPPTSE 184
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
 197-336 2.54e-05

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 47.47  E-value: 2.54e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873  197 NEGEGVGEACEEDGVDTSEEDPTLAGEEDVKDTREEDGADASEEDLTRARQEEGADASEEDPTPAGEEDVKDAREEDGVD 276
Cdd:PTZ00341   930 NQNENVPEHLKEHAEANIEEDAEENVEEDAEENVEENVEENVEENVEENVEENVEENVEENVEENVEENVEENIEENVEE 1009

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217370873  277 TIEEDLTRAGEEDGKDTREEDGADASEEDPTWAGE-EEGADSG-EEDGADASEEDDTITNEK 336
Cdd:PTZ00341  1010 NVEENIEENVEEYDEENVEEVEENVEEYDEENVEEiEENAEENvEENIEENIEEYDEENVEE 1071
PHA03169 PHA03169
hypothetical protein; Provisional
 192-365 3.05e-05

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 46.89  E-value: 3.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873 192 PEDSSNEGEGVGEACEEDGVDTSEEDPTLAGEEDVKDTREEDGADASEEDltraRQEEGADASEEDPTPAGEEDVKDARE 271
Cdd:PHA03169  105 PSPSGSAEELASGLSPENTSGSSPESPASHSPPPSPPSHPGPHEPAPPES----HNPSPNQQPSSFLQPSHEDSPEEPEP 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873 272 EDGVDtiEEDLTRAGEEDGKDTREEDGADASEEDPTWAGEEEGADSGeeDGADASEEDDTITNEKAHSIlNFLKSTQEMY 351
Cdd:PHA03169  181 PTSEP--EPDSPGPPQSETPTSSPPPQSPPDEPGEPQSPTPQQAPSP--NTQQAVEHEDEPTEPEREGP-PFPGHRSHSY 255

                         170
                  ....*....|....
gi 2217370873 352 FYDAWGRPTVMPGV 365
Cdd:PHA03169  256 TVVGWKPSTRPGGV 269
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
 209-357 5.57e-05

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 46.32  E-value: 5.57e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873  209 DGVDTSEEdptlageEDVKDTREEDGADASEEDLTRAR--QEEGADASEE---DPTPAGEEDVKDAREEDGVDTIEEDLT 283
Cdd:PTZ00341   426 DMLDGSED-------ESVEDNEEEHSGDANEEELSVDEhvEEHNADDSGEqqsDDESGEHQSVNEIVEEQSVNEHVEEPT 498

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873  284 RAgeedgkDTREEDGADASEEDPT--WAGEEEGADSG-EEDGADAS--EEDDTITNEKAHSILNFLKSTQEM-------- 350
Cdd:PTZ00341   499 VA------DIVEQETVDEHVEEPAvdENEEQQTADEHvEEPTIAEEhvEEEISTAEEHIEEPASDVQQDSEAaptieipd 572


                   ....*...
gi 2217370873  351 -YFYDAWG 357
Cdd:PTZ00341   573 tLFYDILG 580
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 132-330 5.84e-05

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 46.53  E-value: 5.84e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873  132 EQAELEKQQSLLQEKSQRQHTDGTTISKNKKRKLKKKQQIKRKKAAGLAAKAAGVSFMYQPEDSSNEGEGVGEAcEEDGV 211
Cdd:TIGR00927  661 EESGGEAEQEGETETKGENESEGEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEHEGETEAEGTEDEGEIET-GEEGE 739

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873  212 DTSEEDPTLA---GEEDVKDTREEDGADASEEDLTRARQEEGADASEEDPTPAGEEDVKDAREEDGVDTIEEDL------ 282
Cdd:TIGR00927  740 EVEDEGEGEAegkHEVETEGDRKETEHEGETEAEGKEDEDEGEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKDehegqs 819

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217370873  283 -TRAGEEDGKDTREEDGADASEEDPTWAGEE--------EGADSGEEDGADASEEDD 330
Cdd:TIGR00927  820 eTQADDTEVKDETGEQELNAENQGEAKQDEKgvdggggsDGGDSEEEEEEEEEEEEE 876
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
 204-312 2.34e-04

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 44.39  E-value: 2.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873  204 EACEEDGVDTSEEDPTLAGEEDVKDTRE--EDGADASEEDLTRARQEEGADASEEDPTPAGEEDVKDAREEDGV---DTI 278
Cdd:PTZ00341  1020 EEYDEENVEEVEENVEEYDEENVEEIEEnaEENVEENIEENIEEYDEENVEEIEENIEENIEENVEENVEENVEeieENV 1099

                           90       100       110
                   ....*....|....*....|....*....|....
gi 2217370873  279 EEDLTRAGEEDGKDTREEDGADASEEDPTWAGEE 312
Cdd:PTZ00341  1100 EENVEENAEENAEENAEENAEEYDDENPEEHNEE 1133
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 251-331 3.05e-04

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 43.63  E-value: 3.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873 251 ADASEEDPTPAGEEDVKDAREEDGvdtiEEDLTRAGEEDGKDTREEDGADASEEDPTwAGEEEGADSGEEDGADASEEDD 330
Cdd:COG4547   208 AEELGEDEDEEDEDDEDDSGEQEE----DEEDGEDEDEESDEGAEAEDAEASGDDAE-EGESEAAEAESDEMAEEAEGED 282


                  .
gi 2217370873 331 T 331
Cdd:COG4547   283 S 283
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 193-335 3.88e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 43.83  E-value: 3.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873  193 EDSSNEGEGVGEACEEDGVDTSEEDPTLAGEEDVkDTREEDGADASEEDLTRARQEEGADASEEDPTPAGEEDVKDAREE 272
Cdd:TIGR00927  756 ETEGDRKETEHEGETEAEGKEDEDEGEIQAGEDG-EMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGE 834

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217370873  273 DGVDTIEEDLTRAGEEDGKDTREEDGADASEEDPTWAGEEEGADSGEEDGADASEEDDTITNE 335
Cdd:TIGR00927  835 QELNAENQGEAKQDEKGVDGGGGSDGGDSEEEEEEEEEEEEEEEEEEEEEEEEEENEEPLSLE 897
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 207-316 4.02e-04

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 43.24  E-value: 4.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873 207 EEDGVDTSEEDPtlaGEEDVKDTREEDGADASEEDltrarQEEGADASEEDPTPAGEEDvkDAREEDGVDTIEEDLtrag 286
Cdd:COG4547   209 EELGEDEDEEDE---DDEDDSGEQEEDEEDGEDED-----EESDEGAEAEDAEASGDDA--EEGESEAAEAESDEM---- 274

                          90       100       110
                  ....*....|....*....|....*....|
gi 2217370873 287 EEDGKDTREEDGADASEEDPTWAGEEEGAD 316
Cdd:COG4547   275 AEEAEGEDSEEPGEPWRPNAPPPDDPADPD 304
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
 193-303 6.90e-04

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 42.85  E-value: 6.90e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873  193 EDSSNEGEGVGEACEEDGVDTSEEDPTLAGEEDVKDTREEDGADASE--EDLTRARQEEGADASEEDPTPAGEEDVKDAR 270
Cdd:PTZ00341  1024 EENVEEVEENVEEYDEENVEEIEENAEENVEENIEENIEEYDEENVEeiEENIEENIEENVEENVEENVEEIEENVEENV 1103

                           90       100       110
                   ....*....|....*....|....*....|...
gi 2217370873  271 EEDGVDTIEEDLTRAGEEDGKDTREEDGADASE 303
Cdd:PTZ00341  1104 EENAEENAEENAEENAEEYDDENPEEHNEEYDE 1136
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 192-337 7.88e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 42.68  E-value: 7.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873  192 PEDSSNEGEGVGEACEEDGVDTSEEDptlAGEEDVKDTREEDGADASEEDLTRARQEEGADASEEDPTPAGEEDVKDARE 271
Cdd:TIGR00927  686 PAERKGEQEGEGEIEAKEADHKGETE---AEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVETEGDRK 762

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217370873  272 EDGVDTIEEDLTRAGEEDGKDTREEDGADASEEdptwaGEEEGADSGEEDGADASEEDDTITNEKA 337
Cdd:TIGR00927  763 ETEHEGETEAEGKEDEDEGEIQAGEDGEMKGDE-----GAEGKVEHEGETEAGEKDEHEGQSETQA 823
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 213-331 8.80e-04

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 42.69  E-value: 8.80e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873  213 TSEEDPTLAGEEDVKDTREEDGADASEEDLTRARQEEGADASEEDPTPAGEEDVKDAREEDGVDTIEEDLTRAGEEDGKD 292
Cdd:COG5271    482 TDEDDASDDGDEEEAEEDAEAEADSDELTAEETSADDGADTDAAADPEDSDEDALEDETEGEENAPGSDQDADETDEPEA 561

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 2217370873  293 TREEDGADASEEDPTWAGEEEGADSGEEDGADASEEDDT 331
Cdd:COG5271    562 TAEEDEPDEAEAETEDATENADADETEESADESEEAEAS 600
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 231-337 1.46e-03

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 41.70  E-value: 1.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873 231 EEDGADASEEdltrarqEEGADASEEDPTPAGEEDVKDAREEDGVDTIEEDLTRAGEEDgkDTREEDGADASEEDptwaG 310
Cdd:COG4547   208 AEELGEDEDE-------EDEDDEDDSGEQEEDEEDGEDEDEESDEGAEAEDAEASGDDA--EEGESEAAEAESDE----M 274

                          90       100
                  ....*....|....*....|....*..
gi 2217370873 311 EEEGADSGEEDGADASEEDDTITNEKA 337
Cdd:COG4547   275 AEEAEGEDSEEPGEPWRPNAPPPDDPA 301
PRK05901 PRK05901
RNA polymerase sigma factor; Provisional
 132-345 1.59e-03

RNA polymerase sigma factor; Provisional


Pssm-ID: 235640 [Multi-domain]  Cd Length: 509  Bit Score: 41.52  E-value: 1.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873 132 EQAELEKQQSLLQEKSQRQHTDGTTISKNKKRKLKKKQQIKRKKAAGLAAKAAGVSFMYQPEDSSNEGEGVGEACEEDGV 211
Cdd:PRK05901    9 ELAAEEEAKKKLKKLAAKSKSKGFITKEEIKEALESKKKTPEQIDQVLIFLSGMVKDTDDATESDIPKKKTKTAAKAAAA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873 212 DTSEEDPTLAGEEDVKDTREEDGADASEEDLTRARQEEGADA-SEEDPTPAGEEDVKDAREEDGVDTIEEDltragEEDG 290
Cdd:PRK05901   89 KAPAKKKLKDELDSSKKAEKKNALDKDDDLNYVKDIDVLNQAdDDDDDDDDDDLDDDDIDDDDDDEDDDED-----DDDD 163

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2217370873 291 KDTREEDGADASEEDPTWAGEEEGADSGEEDGADASEEDDTITNEKAHSILNFLK 345
Cdd:PRK05901  164 DVDDEDEEKKEAKELEKLSDDDDFVWDEDDSEALRQARKDAKLTATADPVKAYLK 218
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 192-331 1.81e-03

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 41.43  E-value: 1.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873 192 PEDSSNEGEGVGEACEEDGVDTSEEDPTLAGEEDVKDTREEDGADASEEDlTRARQEEGADASEedptpAGEEDVKDARE 271
Cdd:PRK12678   73 PAAAARRAARAAAAARQAEQPAAEAAAAKAEAAPAARAAAAAAAEAASAP-EAAQARERRERGE-----AARRGAARKAG 146

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873 272 EDGVDTIEEDLTRAGEEDGKDTREEDGADASEEDPTWAGEEEGADSGEEDGADASEEDDT 331
Cdd:PRK12678  147 EGGEQPATEARADAAERTEEEERDERRRRGDREDRQAEAERGERGRREERGRDGDDRDRR 206
TFIIF_alpha pfam05793
Transcription initiation factor IIF, alpha subunit (TFIIF-alpha); Transcription initiation ...
 193-336 2.63e-03

Transcription initiation factor IIF, alpha subunit (TFIIF-alpha); Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) or RNA polymerase II-associating protein 74 (RAP74) is the large subunit of transcription factor IIF (TFIIF), which is essential for accurate initiation and stimulates elongation by RNA polymerase II.


Pssm-ID: 310411 [Multi-domain]  Cd Length: 528  Bit Score: 40.70  E-value: 2.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873 193 EDSSNEGEGVGEACEEDGVDTSEEDPTLAGEEDVKDTREEDGADASEEDltRARQEEGADASEEDPTPAGEEDVKDAREE 272
Cdd:pfam05793 197 EETEGEKGGGGRGKDLKIKDLEGDDEDDGDESDKGGEDGDEEKKKKKKK--KLAKNKKKLDDDKKKKRGGDDDAFEYDSD 274

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217370873 273 DGVD-TIEEDLTRAGEEDGKDTREEDGADASEEDPtwAGEEEGADSGEEDGADASEEDDTITNEK 336
Cdd:pfam05793 275 DGDDeGREEDYISDSSASGNDPEEREDKLSPEEPA--KGEIEQSDDSEESEEEKNEEEGKLSKKG 337
DNA_pol_phi pfam04931
DNA polymerase phi; This family includes the fifth essential DNA polymerase in yeast EC:2.7.7. ...
 192-305 3.49e-03

DNA polymerase phi; This family includes the fifth essential DNA polymerase in yeast EC:2.7.7.7. Pol5p is localized exclusively to the nucleolus and binds near or at the enhancer region of rRNA-encoding DNA repeating units.


Pssm-ID: 461488  Cd Length: 765  Bit Score: 40.68  E-value: 3.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873 192 PEDSSNEGEGVGEACEEDGVDTSEEDptlagEEDvkdtrEEDGADASEEDltrarqeegaDASEEDPtpagEEDVKDARE 271
Cdd:pfam04931 625 ARENPEGQQELFEDEDEDEEDDDEEE-----DDD-----DEDDEDSEEDD----------DEDDDDE----DEEDDDDED 680

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2217370873 272 EDGVDTIEEDLTRAGEEDGKDtrEEDGADASEED 305
Cdd:pfam04931 681 VDEIDELRAKLAEALGEHGDD--ADDDDSDSDED 712
COG5593 COG5593
Nucleic-acid-binding protein possibly involved in ribosomal biogenesis [Translation, ribosomal ...
 185-339 4.31e-03

Nucleic-acid-binding protein possibly involved in ribosomal biogenesis [Translation, ribosomal structure and biogenesis];


Pssm-ID: 227880 [Multi-domain]  Cd Length: 821  Bit Score: 40.41  E-value: 4.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873 185 GVSFMyQPEdSSNEGEGVGEACEEDGVDTSEEDPTLAGEEDVKDTRE-------EDGADASEEDLTRARQEEGADASEED 257
Cdd:COG5593   612 GTSIM-QPL-FSGVNDSLVKASMHDQGPVNTEDWLTKKVEDIKPEDKffyqyftKKTADGKGKKSNKASFDSDDEMDENE 689

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873 258 PTPA---GEEDVKDAREEDGVDTIEEDLTRAGEEDGKDTREEDGADASEEDPTWAGEEEGADS------GEEDGAD---- 324
Cdd:COG5593   690 IWSAlvkSRPDVEDDSDDSELDFAEDDFSDSTSDDEPKLDAIDDEDAKSEGSQESDQEEGLDEifysfdGEQDNSDsfae 769

                         170       180
                  ....*....|....*....|.
gi 2217370873 325 ------ASEEDDTITNEKAHS 339
Cdd:COG5593   770 sseedeSSEEEKEEEENKEVS 790
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 212-327 5.14e-03

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 40.00  E-value: 5.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873  212 DTSEEDPTLAGEEDVKDTREEDGADASEEDLTRARQEEGADASEEDPTPAGE-EDVKDAREEDGVDTIEEDLTRA-GEED 289
Cdd:COG5271    545 NAPGSDQDADETDEPEATAEEDEPDEAEAETEDATENADADETEESADESEEaEASEDEAAEEEEADDDEADADAdGAAD 624

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2217370873  290 GKDTREEDGADASEEDPTWAGEEEGADSGEEDGADASE 327
Cdd:COG5271    625 EEETEEEAAEDEAAEPETDASEAADEDADAETEAEASA 662
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 195-335 5.48e-03

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 39.58  E-value: 5.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873 195 SSNEGEGVGEACEEDGVDTSEEDPTLAGEEDVKDTREEDGA--DASEEDLTRARQEE-GADASEEDptpagEEDVKDARE 271
Cdd:PRK13108  322 EPNQPDDVAEAVKAEVAEVTDEVAAESVVQVADRDGESTPAveETSEADIEREQPGDlAGQAPAAH-----QVDAEAASA 396

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217370873 272 EDGVDTIEEDLTRAGEEDGKDTREEDGADASEEDPTwAGEEEGADSGEEDGADASEEDDTITNE 335
Cdd:PRK13108  397 APEEPAALASEAHDETEPEVPEKAAPIPDPAKPDEL-AVAGPGDDPAEPDGIRRQDDFSSRRRR 459
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 192-337 6.21e-03

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 39.61  E-value: 6.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873  192 PEDSSNEGEGVGEACEEDGVDTSEEDPTLAGEEDVKDTREE------------DGADASEEDLTRARQEEGADAsEEDPT 259
Cdd:COG5271    714 AEEADTEADGTAEEAEEAAEEAESADEEAASLPDEADAEEEaeeaeeaeeddaDGLEEALEEEKADAEEAATDE-EAEAA 792

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217370873  260 PAGEEDVKDAREEDGVDTIEEDLTRAGEEDGKDTREEDGADASEEDPTWAGEEEGADSGEEDGADASEEDDTITNEKA 337
Cdd:COG5271    793 AEEKEKVADEDQDTDEDALLDEAEADEEEDLDGEDEETADEALEDIEAGIAEDDEEDDDAAAAKDVDADLDLDADLAA 870
COG5137 COG5137
Histone chaperone involved in gene silencing [Transcription / Chromatin structure and dynamics] ...
 193-313 6.21e-03

Histone chaperone involved in gene silencing [Transcription / Chromatin structure and dynamics];


Pssm-ID: 227466 [Multi-domain]  Cd Length: 279  Bit Score: 38.82  E-value: 6.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873 193 EDSSNEGEGVGEACEEDGVDTSEEDPTLAGEEDVKDTREEDGADASEEDLTRARQEEGADASEEDPTPAGEE-DVKDARE 271
Cdd:COG5137   161 DEDNDEAPPAQPDVDNEEEERLEESDGREEEEDEEVGSDSYGEGNRELNEEEEEEAEGSDDGEDVVDYEGERiDKKQGEE 240

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2217370873 272 EDG---VDTIEEdltragEEDGKDTREEDGADASEEDPTWAGEEE 313
Cdd:COG5137   241 EEMeeeVINLFE------IEWEEESPSEEVPRNNEESPAKKQKVE 279
DNA_pol_phi pfam04931
DNA polymerase phi; This family includes the fifth essential DNA polymerase in yeast EC:2.7.7. ...
 260-330 6.40e-03

DNA polymerase phi; This family includes the fifth essential DNA polymerase in yeast EC:2.7.7.7. Pol5p is localized exclusively to the nucleolus and binds near or at the enhancer region of rRNA-encoding DNA repeating units.


Pssm-ID: 461488  Cd Length: 765  Bit Score: 39.53  E-value: 6.40e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217370873 260 PAGEEDVKDAREEDGVDTIEEDltragEEDgkdtrEEDGADASEEDptwAGEEEGADSGEEDGADASEEDD 330
Cdd:pfam04931 629 PEGQQELFEDEDEDEEDDDEEE-----DDD-----DEDDEDSEEDD---DEDDDDEDEEDDDDEDVDEIDE 686
COG5137 COG5137
Histone chaperone involved in gene silencing [Transcription / Chromatin structure and dynamics] ...
 207-327 6.49e-03

Histone chaperone involved in gene silencing [Transcription / Chromatin structure and dynamics];


Pssm-ID: 227466 [Multi-domain]  Cd Length: 279  Bit Score: 38.82  E-value: 6.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873 207 EEDGVDTSEEDPTlAGEEDVKDTREEDGaDASEEDLTRARQEEGaDASEEDPTPAGEEDVKDAREEDGVDTIEEDLTRaG 286
Cdd:COG5137   161 DEDNDEAPPAQPD-VDNEEEERLEESDG-REEEEDEEVGSDSYG-EGNRELNEEEEEEAEGSDDGEDVVDYEGERIDK-K 236

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2217370873 287 EEDGKDTREEDGADASEEDPTWAGEEEGADSGEEDGADASE 327
Cdd:COG5137   237 QGEEEEMEEEVINLFEIEWEEESPSEEVPRNNEESPAKKQK 277
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 192-335 6.88e-03

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 39.61  E-value: 6.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217370873  192 PEDSSNEGEGVGEACEEDGVDTSEEDPTLAGEEDVKDTREEDGADASEEDLTRARQEEGADASEEDPTPAGEEDVKDARE 271
Cdd:COG5271    677 SEDAEEDADAAAAEASDDEEETEEADEDAETASEEADAEEADTEADGTAEEAEEAAEEAESADEEAASLPDEADAEEEAE 756

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217370873  272 EDGVDTIEE-DLTRAGEEDGKDTREEDGADASEEDPTWAgEEEGADSGEEDGADASEEDDTITNE 335
Cdd:COG5271    757 EAEEAEEDDaDGLEEALEEEKADAEEAATDEEAEAAAEE-KEKVADEDQDTDEDALLDEAEADEE 820
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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