NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2217360866|ref|XP_047274546|]
View 

WD repeat-containing protein 27 isoform X16 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-236 9.59e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 86.23  E-value: 9.59e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360866  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAFGnkVNPLLICSASLD-YVIMWNLDECRE-KVLQGLVprgtvmgsllGK 125
Cdd:cd00200   114 DKT-IKVWDVETGK-CLTTLRGHTDWVNSVAFS--PDGTFVASSSQDgTIKLWDLRTGKCvATLTGHT----------GE 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360866 126 VLCLQLSLDDHVVAVCAGNK-IFMLDIETQAVRAELQGHLGPVTAVEFCPWRaGTLISASEDRGFKVWDHCTGSLIYsss 204
Cdd:cd00200   180 VNSVAFSPDGEKLLSSSSDGtIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG-YLLASGSEDGTIRVWDLRTGECVQ--- 255

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2217360866 205 VLSAY--PLLSLFIDAESRQLVTGCADGQLWIFS 236
Cdd:cd00200   256 TLSGHtnSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-236 9.59e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 86.23  E-value: 9.59e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360866  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAFGnkVNPLLICSASLD-YVIMWNLDECRE-KVLQGLVprgtvmgsllGK 125
Cdd:cd00200   114 DKT-IKVWDVETGK-CLTTLRGHTDWVNSVAFS--PDGTFVASSSQDgTIKLWDLRTGKCvATLTGHT----------GE 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360866 126 VLCLQLSLDDHVVAVCAGNK-IFMLDIETQAVRAELQGHLGPVTAVEFCPWRaGTLISASEDRGFKVWDHCTGSLIYsss 204
Cdd:cd00200   180 VNSVAFSPDGEKLLSSSSDGtIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG-YLLASGSEDGTIRVWDLRTGECVQ--- 255

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2217360866 205 VLSAY--PLLSLFIDAESRQLVTGCADGQLWIFS 236
Cdd:cd00200   256 TLSGHtnSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
48-237 1.78e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.11  E-value: 1.78e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360866  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAF---GNkvnplLICSASLDYVIM-WNLDECREKvlqglvprgTVMGSLL 123
Cdd:COG2319   225 DGT-VRLWDLATGK-LLRTLTGHSGSVRSVAFspdGR-----LLASGSADGTVRlWDLATGELL---------RTLTGHS 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360866 124 GKVLCLQLSLDDHVVAV-CAGNKIFMLDIETQAVRAELQGHLGPVTAVEFCPWRaGTLISASEDRGFKVWDHCTGSLIYS 202
Cdd:COG2319   289 GGVNSVAFSPDGKLLASgSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-KTLASGSDDGTVRLWDLATGELLRT 367

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2217360866 203 SSVLSAyPLLSLFIDAESRQLVTGCADGQLWIFSL 237
Cdd:COG2319   368 LTGHTG-AVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 153-193 3.21e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 3.21e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2217360866  153 TQAVRAELQGHLGPVTAVEFCPwRAGTLISASEDRGFKVWD 193
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
158-193 4.17e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 4.17e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2217360866 158 AELQGHLGPVTAVEFCPWRAgTLISASEDRGFKVWD 193
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-236 9.59e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 86.23  E-value: 9.59e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360866  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAFGnkVNPLLICSASLD-YVIMWNLDECRE-KVLQGLVprgtvmgsllGK 125
Cdd:cd00200   114 DKT-IKVWDVETGK-CLTTLRGHTDWVNSVAFS--PDGTFVASSSQDgTIKLWDLRTGKCvATLTGHT----------GE 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360866 126 VLCLQLSLDDHVVAVCAGNK-IFMLDIETQAVRAELQGHLGPVTAVEFCPWRaGTLISASEDRGFKVWDHCTGSLIYsss 204
Cdd:cd00200   180 VNSVAFSPDGEKLLSSSSDGtIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG-YLLASGSEDGTIRVWDLRTGECVQ--- 255

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2217360866 205 VLSAY--PLLSLFIDAESRQLVTGCADGQLWIFS 236
Cdd:cd00200   256 TLSGHtnSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
48-237 1.78e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.11  E-value: 1.78e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360866  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAF---GNkvnplLICSASLDYVIM-WNLDECREKvlqglvprgTVMGSLL 123
Cdd:COG2319   225 DGT-VRLWDLATGK-LLRTLTGHSGSVRSVAFspdGR-----LLASGSADGTVRlWDLATGELL---------RTLTGHS 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360866 124 GKVLCLQLSLDDHVVAV-CAGNKIFMLDIETQAVRAELQGHLGPVTAVEFCPWRaGTLISASEDRGFKVWDHCTGSLIYS 202
Cdd:COG2319   289 GGVNSVAFSPDGKLLASgSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-KTLASGSDDGTVRLWDLATGELLRT 367

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2217360866 203 SSVLSAyPLLSLFIDAESRQLVTGCADGQLWIFSL 237
Cdd:COG2319   368 LTGHTG-AVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
48-240 5.53e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.57  E-value: 5.53e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360866  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAF---GNkvnpLLIcSASLDYVI-MWNLDECRE-KVLQGLVprgtvmgsl 122
Cdd:COG2319   141 DGT-VRLWDLATGK-LLRTLTGHSGAVTSVAFspdGK----LLA-SGSDDGTVrLWDLATGKLlRTLTGHT--------- 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360866 123 lGKVLCLQLSLDDHVVAVCAGNK-IFMLDIETQAVRAELQGHLGPVTAVEFCPWRAgTLISASEDRGFKVWDHCTGSLIY 201
Cdd:COG2319   205 -GAVRSVAFSPDGKLLASGSADGtVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGELLR 282

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2217360866 202 SSSVLSAyPLLSLFIDAESRQLVTGCADGQLWIFSLMDG 240
Cdd:COG2319   283 TLTGHSG-GVNSVAFSPDGKLLASGSDDGTVRLWDLATG 320
WD40 COG2319
WD40 repeat [General function prediction only];
48-237 3.15e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 77.26  E-value: 3.15e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360866  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAF---GNkvnplLICSASLD-YVIMWNLDECRE-KVLQGLVPRgtvmgsl 122
Cdd:COG2319   183 DGT-VRLWDLATGK-LLRTLTGHTGAVRSVAFspdGK-----LLASGSADgTVRLWDLATGKLlRTLTGHSGS------- 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360866 123 lgkVLCLQLSLDDHVVAVC-AGNKIFMLDIETQAVRAELQGHLGPVTAVEFCPwRAGTLISASEDRGFKVWDHCTGSLIY 201
Cdd:COG2319   249 ---VRSVAFSPDGRLLASGsADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLR 324

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2217360866 202 SSSVlSAYPLLSLFIDAESRQLVTGCADGQLWIFSL 237
Cdd:COG2319   325 TLTG-HTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 67-242 1.56e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.05  E-value: 1.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360866  67 LRGHHQPITAMAFGNKVNplLICSASLD-YVIMWNLDECR-EKVLQG---------LVPRGTVM--GSL----------- 122
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGK--LLATGSGDgTIKVWDLETGElLRTLKGhtgpvrdvaASADGTYLasGSSdktirlwdlet 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360866 123 ----------LGKVLCLQLSLDDHVVAVCAGNK-IFMLDIETQAVRAELQGHLGPVTAVEFCPwrAGTLI-SASEDRGFK 190
Cdd:cd00200    83 gecvrtltghTSYVSSVAFSPDGRILSSSSRDKtIKVWDVETGKCLTTLRGHTDWVNSVAFSP--DGTFVaSSSQDGTIK 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2217360866 191 VWDHCTGSLIYsssVLSAY--PLLSLFIDAESRQLVTGCADGQLWIFSLMDGHH 242
Cdd:cd00200   161 LWDLRTGKCVA---TLTGHtgEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKC 211
WD40 COG2319
WD40 repeat [General function prediction only];
55-240 1.43e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.01  E-value: 1.43e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360866  55 WNTKDPSHQLLILRGHHQPITAMAFGNKVNPLLicSASLDYVI-MWNLDecrekvlQGLVPRgtVMGSLLGKVLCLQLSL 133
Cdd:COG2319    62 LLDAAAGALLATLLGHTAAVLSVAFSPDGRLLA--SASADGTVrLWDLA-------TGLLLR--TLTGHTGAVRSVAFSP 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360866 134 DDHVVAVCAGNK-IFMLDIETQAVRAELQGHLGPVTAVEFCPwrAG-TLISASEDRGFKVWDHCTGSLIYSSSVLSAyPL 211
Cdd:COG2319   131 DGKTLASGSADGtVRLWDLATGKLLRTLTGHSGAVTSVAFSP--DGkLLASGSDDGTVRLWDLATGKLLRTLTGHTG-AV 207

                         170       180
                  ....*....|....*....|....*....
gi 2217360866 212 LSLFIDAESRQLVTGCADGQLWIFSLMDG 240
Cdd:COG2319   208 RSVAFSPDGKLLASGSADGTVRLWDLATG 236
WD40 COG2319
WD40 repeat [General function prediction only];
63-240 4.99e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.00  E-value: 4.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360866  63 QLLILRGHHQPITAMAFGNKVNPLLICSASLDYVIMWNLDECREKVLQGLVPRgtvmgsllgkVLCLQLSLDDHVVAVCA 142
Cdd:COG2319    28 LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA----------VLSVAFSPDGRLLASAS 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360866 143 GNKIFML-DIETQAVRAELQGHLGPVTAVEFCPwRAGTLISASEDRGFKVWDHCTGSLIYSSSVLSAyPLLSLFIDAESR 221
Cdd:COG2319    98 ADGTVRLwDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTLTGHSG-AVTSVAFSPDGK 175

                         170
                  ....*....|....*....
gi 2217360866 222 QLVTGCADGQLWIFSLMDG 240
Cdd:COG2319   176 LLASGSDDGTVRLWDLATG 194
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 114-240 1.26e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.19  E-value: 1.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360866 114 PRGTVMGSLlGKVLCLQLSLD-DHVVAVCAGNKIFMLDIETQAVRAELQGHLGPVTAVEFCPWRaGTLISASEDRGFKVW 192
Cdd:cd00200     1 LRRTLKGHT-GGVTCVAFSPDgKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLW 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2217360866 193 D----HCTGSLI-YSSSVlsayplLSLFIDAESRQLVTGCADGQLWIFSLMDG 240
Cdd:cd00200    79 DletgECVRTLTgHTSYV------SSVAFSPDGRILSSSSRDKTIKVWDVETG 125
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 157-241 1.76e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.72  E-value: 1.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360866 157 RAELQGHLGPVTAVEFCPWRaGTLISASEDRGFKVWDHCTGSLIYSSSVLSAyPLLSLFIDAESRQLVTGCADGQLWIFS 236
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGELLRTLKGHTG-PVRDVAASADGTYLASGSSDKTIRLWD 79


                  ....*
gi 2217360866 237 LMDGH 241
Cdd:cd00200    80 LETGE 84
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 153-193 3.21e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 3.21e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2217360866  153 TQAVRAELQGHLGPVTAVEFCPwRAGTLISASEDRGFKVWD 193
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
158-193 4.17e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 4.17e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2217360866 158 AELQGHLGPVTAVEFCPWRAgTLISASEDRGFKVWD 193
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH