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Conserved domains on  [gi|2217355436|ref|XP_047273024|]
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rapamycin-insensitive companion of mTOR isoform X4 [Homo sapiens]

Protein Classification

RICTOR_N and RICTOR_M domain-containing protein( domain architecture ID 10630570)

protein containing domains RICTOR_N, RICTOR_M, RasGEF_N_2, and RICTOR_phospho

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RICTOR_N pfam14664
Rapamycin-insensitive companion of mTOR, N-term; Rictor appears to serve as a scaffolding ...
 5-384 2.18e-127

Rapamycin-insensitive companion of mTOR, N-term; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the N-terminal conserved section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.


:

Pssm-ID: 464246  Cd Length: 372  Bit Score: 402.68  E-value: 2.18e-127
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217355436    5 GHLNNFTKLLCDIGHSEEKLGFhyEDIIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKVLKLKVDYLIARCIDIQQ 84
Cdd:pfam14664    1 EKANDLVDLLKRHPTLKYDLVL--SDFLLRIQPMLLSESKEVRAAGYRILRYLISDEESLQLLRKLHLDIFIIRSLSKDN 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217355436   85 SNEVERTQALRLVRKMITVNA--SLFPSSVTNSLIAVGNdglQERDRMVRACIAIICELALQNPEVVALRGGLNTILKNV 162
Cdd:pfam14664   79 KNEVEREQALKLIRAFLEIKDgvSEISRGVVRALVAIAE---HEDDRLRRICLETLCELALLDPELVVRCGGLRVLLDAL 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217355436  163 IDcQLSRINEALITTILHLLNHPKTRQYVRADVELERILAPYTDfhyrhspDTAEGQLKEDREARFLASKMGIIATFRSW 242
Cdd:pfam14664  156 LE-GSFELAESLLGALLYLLDSPRTRKYLRPGFDLEVLLSPFTD-------SLDANTKGDSNEERLQASAKAISSLLKSW 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217355436  243 AGIINLCKPGNSGIQSLIGVLCIPNMEIRRGLLEVLYDIFRLPLPVVTEEFIEALLSVdPGRFQDSWRLSDGFVAAEAKT 322
Cdd:pfam14664  228 PGLMYLSMNDFRPLRSLVDSLRLPSLEVREAILDLLFDLLRIKPPSWTSSFLALTTYG-RVANLDSWSLSEGFVAAEFKS 306

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217355436  323 ILPHRAR-SRPDLMDNYLALILSAFIRNGLLEGLVEVI-TNSDDHISVRATILLGELLHMANTI 384
Cdd:pfam14664  307 ILPSESSfSRENLVNHYLALLLLVFIEAGLLEALVEVIeESSDSSLSRKATLLLGELLHLANRL 370
RICTOR_phospho pfam14665
Rapamycin-insensitive companion of mTOR, phosphorylation-site; Rictor appears to serve as a ...
 1032-1135 8.19e-45

Rapamycin-insensitive companion of mTOR, phosphorylation-site; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient- and growth-factor signalling. This short region is the phoshorylation site. Rictor does interact with 14-3-3 in a Thr1135-dependent manner. Rictor can be inhibited by short-term rapamycin treatment showing that Thr1135 is an mTORC1-regulated site.


:

Pssm-ID: 464247  Cd Length: 108  Bit Score: 157.72  E-value: 8.19e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217355436 1032 FPFFASSKLVKNRILNSLTLPNKKHRSSSDPKGGKLSSESKTSNRRIRTLTEPSVDFNHSDDFTPISTVQKTLQ---LET 1108
Cdd:pfam14665    2 FTFLSSSRVVRNRFLNSLTLPKKKLRSSSDPKGGKSSSNKKSGLRRNRTVTEPSSDDNHSGDFFPPVFRVPKSPtqsLET 81

                           90       100
                   ....*....|....*....|....*..
gi 2217355436 1109 SFMGNKHIEDTGSTPSIGENDLKFTKN 1135
Cdd:pfam14665   82 SFVGSKIEEDGGSTPSIGENDLKLPRL 108
RICTOR_M pfam14666
Rapamycin-insensitive companion of mTOR, middle domain; Rictor appears to serve as a ...
 584-687 2.62e-40

Rapamycin-insensitive companion of mTOR, middle domain; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the more conserved central section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.


:

Pssm-ID: 464248  Cd Length: 104  Bit Score: 144.53  E-value: 2.62e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217355436  584 SSGMKPERSLQNNGLLTTLSQHYFLFIGTLSCHPHGVKMLEKCSVFQCLLNLCSLKNQDHLLKLTVSSLDYSRDGLARVI 663
Cdd:pfam14666    1 SGITAGDPLFSKQRLETTLSRGYFLFIGVLSSSKNGLKLLEKWNIFTILYHIVELKSRDDLLKLILSSLDYSLDGHPRII 80

                           90       100
                   ....*....|....*....|....
gi 2217355436  664 LSKILTAATDACRLYATKHLRVLL 687
Cdd:pfam14666   81 LSKALTSSSESIRLYATKHLRVLL 104
RasGEF_N_2 pfam14663
Rapamycin-insensitive companion of mTOR RasGEF_N domain; Rictor appears to serve as a ...
 694-800 6.04e-38

Rapamycin-insensitive companion of mTOR RasGEF_N domain; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the more conserved central section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.


:

Pssm-ID: 464245  Cd Length: 107  Bit Score: 138.11  E-value: 6.04e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217355436  694 FNNWGIELLVTQLHDKNKTISSEALDILDEACEDKANLHALIQMKPALSHLGDKGLLLLLRFLSIPKGFSYLNERGYVAK 773
Cdd:pfam14663    1 FEEWGIELLVTQLYDPSPEVVAAAVDVLYEACDDKENLESLVSLRPSLDHLGEIGSPLLLRFLSTPSGFKYLNELGFVEN 80

                           90       100
                   ....*....|....*....|....*..
gi 2217355436  774 QLEKWHREYNSKYVDLIEEQLNEALTT 800
Cdd:pfam14663   81 ELDKWFEERNLEYVLKVEEFLAEALTD 107
RICTOR_V pfam14668
Rapamycin-insensitive companion of mTOR, domain 5; Rictor appears to serve as a scaffolding ...
 869-938 6.74e-34

Rapamycin-insensitive companion of mTOR, domain 5; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. These long eukaryotic proteins carry several well-conserved domains, and this is No.5.


:

Pssm-ID: 464249  Cd Length: 71  Bit Score: 124.88  E-value: 6.74e-34
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217355436  869 KLKASLWALGNIGSSNWGLNLLQEENVIPDILKLAKQCEVLSIRGTCVYVLGLIAKTKQGCDILKCHNWD 938
Cdd:pfam14668    2 KLKAALWAIGHIGSSPLGIQLLEEYDIVEDIVKIAEESPVLSLRGTAFYVLGLISSTEEGAEILDELGWE 71
 
Name Accession Description Interval E-value
RICTOR_N pfam14664
Rapamycin-insensitive companion of mTOR, N-term; Rictor appears to serve as a scaffolding ...
 5-384 2.18e-127

Rapamycin-insensitive companion of mTOR, N-term; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the N-terminal conserved section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.


Pssm-ID: 464246  Cd Length: 372  Bit Score: 402.68  E-value: 2.18e-127
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217355436    5 GHLNNFTKLLCDIGHSEEKLGFhyEDIIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKVLKLKVDYLIARCIDIQQ 84
Cdd:pfam14664    1 EKANDLVDLLKRHPTLKYDLVL--SDFLLRIQPMLLSESKEVRAAGYRILRYLISDEESLQLLRKLHLDIFIIRSLSKDN 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217355436   85 SNEVERTQALRLVRKMITVNA--SLFPSSVTNSLIAVGNdglQERDRMVRACIAIICELALQNPEVVALRGGLNTILKNV 162
Cdd:pfam14664   79 KNEVEREQALKLIRAFLEIKDgvSEISRGVVRALVAIAE---HEDDRLRRICLETLCELALLDPELVVRCGGLRVLLDAL 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217355436  163 IDcQLSRINEALITTILHLLNHPKTRQYVRADVELERILAPYTDfhyrhspDTAEGQLKEDREARFLASKMGIIATFRSW 242
Cdd:pfam14664  156 LE-GSFELAESLLGALLYLLDSPRTRKYLRPGFDLEVLLSPFTD-------SLDANTKGDSNEERLQASAKAISSLLKSW 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217355436  243 AGIINLCKPGNSGIQSLIGVLCIPNMEIRRGLLEVLYDIFRLPLPVVTEEFIEALLSVdPGRFQDSWRLSDGFVAAEAKT 322
Cdd:pfam14664  228 PGLMYLSMNDFRPLRSLVDSLRLPSLEVREAILDLLFDLLRIKPPSWTSSFLALTTYG-RVANLDSWSLSEGFVAAEFKS 306

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217355436  323 ILPHRAR-SRPDLMDNYLALILSAFIRNGLLEGLVEVI-TNSDDHISVRATILLGELLHMANTI 384
Cdd:pfam14664  307 ILPSESSfSRENLVNHYLALLLLVFIEAGLLEALVEVIeESSDSSLSRKATLLLGELLHLANRL 370
RICTOR_phospho pfam14665
Rapamycin-insensitive companion of mTOR, phosphorylation-site; Rictor appears to serve as a ...
 1032-1135 8.19e-45

Rapamycin-insensitive companion of mTOR, phosphorylation-site; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient- and growth-factor signalling. This short region is the phoshorylation site. Rictor does interact with 14-3-3 in a Thr1135-dependent manner. Rictor can be inhibited by short-term rapamycin treatment showing that Thr1135 is an mTORC1-regulated site.


Pssm-ID: 464247  Cd Length: 108  Bit Score: 157.72  E-value: 8.19e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217355436 1032 FPFFASSKLVKNRILNSLTLPNKKHRSSSDPKGGKLSSESKTSNRRIRTLTEPSVDFNHSDDFTPISTVQKTLQ---LET 1108
Cdd:pfam14665    2 FTFLSSSRVVRNRFLNSLTLPKKKLRSSSDPKGGKSSSNKKSGLRRNRTVTEPSSDDNHSGDFFPPVFRVPKSPtqsLET 81

                           90       100
                   ....*....|....*....|....*..
gi 2217355436 1109 SFMGNKHIEDTGSTPSIGENDLKFTKN 1135
Cdd:pfam14665   82 SFVGSKIEEDGGSTPSIGENDLKLPRL 108
RICTOR_M pfam14666
Rapamycin-insensitive companion of mTOR, middle domain; Rictor appears to serve as a ...
 584-687 2.62e-40

Rapamycin-insensitive companion of mTOR, middle domain; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the more conserved central section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.


Pssm-ID: 464248  Cd Length: 104  Bit Score: 144.53  E-value: 2.62e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217355436  584 SSGMKPERSLQNNGLLTTLSQHYFLFIGTLSCHPHGVKMLEKCSVFQCLLNLCSLKNQDHLLKLTVSSLDYSRDGLARVI 663
Cdd:pfam14666    1 SGITAGDPLFSKQRLETTLSRGYFLFIGVLSSSKNGLKLLEKWNIFTILYHIVELKSRDDLLKLILSSLDYSLDGHPRII 80

                           90       100
                   ....*....|....*....|....
gi 2217355436  664 LSKILTAATDACRLYATKHLRVLL 687
Cdd:pfam14666   81 LSKALTSSSESIRLYATKHLRVLL 104
RasGEF_N_2 pfam14663
Rapamycin-insensitive companion of mTOR RasGEF_N domain; Rictor appears to serve as a ...
 694-800 6.04e-38

Rapamycin-insensitive companion of mTOR RasGEF_N domain; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the more conserved central section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.


Pssm-ID: 464245  Cd Length: 107  Bit Score: 138.11  E-value: 6.04e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217355436  694 FNNWGIELLVTQLHDKNKTISSEALDILDEACEDKANLHALIQMKPALSHLGDKGLLLLLRFLSIPKGFSYLNERGYVAK 773
Cdd:pfam14663    1 FEEWGIELLVTQLYDPSPEVVAAAVDVLYEACDDKENLESLVSLRPSLDHLGEIGSPLLLRFLSTPSGFKYLNELGFVEN 80

                           90       100
                   ....*....|....*....|....*..
gi 2217355436  774 QLEKWHREYNSKYVDLIEEQLNEALTT 800
Cdd:pfam14663   81 ELDKWFEERNLEYVLKVEEFLAEALTD 107
RICTOR_V pfam14668
Rapamycin-insensitive companion of mTOR, domain 5; Rictor appears to serve as a scaffolding ...
 869-938 6.74e-34

Rapamycin-insensitive companion of mTOR, domain 5; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. These long eukaryotic proteins carry several well-conserved domains, and this is No.5.


Pssm-ID: 464249  Cd Length: 71  Bit Score: 124.88  E-value: 6.74e-34
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217355436  869 KLKASLWALGNIGSSNWGLNLLQEENVIPDILKLAKQCEVLSIRGTCVYVLGLIAKTKQGCDILKCHNWD 938
Cdd:pfam14668    2 KLKAALWAIGHIGSSPLGIQLLEEYDIVEDIVKIAEESPVLSLRGTAFYVLGLISSTEEGAEILDELGWE 71
 
Name Accession Description Interval E-value
RICTOR_N pfam14664
Rapamycin-insensitive companion of mTOR, N-term; Rictor appears to serve as a scaffolding ...
 5-384 2.18e-127

Rapamycin-insensitive companion of mTOR, N-term; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the N-terminal conserved section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.


Pssm-ID: 464246  Cd Length: 372  Bit Score: 402.68  E-value: 2.18e-127
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217355436    5 GHLNNFTKLLCDIGHSEEKLGFhyEDIIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKVLKLKVDYLIARCIDIQQ 84
Cdd:pfam14664    1 EKANDLVDLLKRHPTLKYDLVL--SDFLLRIQPMLLSESKEVRAAGYRILRYLISDEESLQLLRKLHLDIFIIRSLSKDN 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217355436   85 SNEVERTQALRLVRKMITVNA--SLFPSSVTNSLIAVGNdglQERDRMVRACIAIICELALQNPEVVALRGGLNTILKNV 162
Cdd:pfam14664   79 KNEVEREQALKLIRAFLEIKDgvSEISRGVVRALVAIAE---HEDDRLRRICLETLCELALLDPELVVRCGGLRVLLDAL 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217355436  163 IDcQLSRINEALITTILHLLNHPKTRQYVRADVELERILAPYTDfhyrhspDTAEGQLKEDREARFLASKMGIIATFRSW 242
Cdd:pfam14664  156 LE-GSFELAESLLGALLYLLDSPRTRKYLRPGFDLEVLLSPFTD-------SLDANTKGDSNEERLQASAKAISSLLKSW 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217355436  243 AGIINLCKPGNSGIQSLIGVLCIPNMEIRRGLLEVLYDIFRLPLPVVTEEFIEALLSVdPGRFQDSWRLSDGFVAAEAKT 322
Cdd:pfam14664  228 PGLMYLSMNDFRPLRSLVDSLRLPSLEVREAILDLLFDLLRIKPPSWTSSFLALTTYG-RVANLDSWSLSEGFVAAEFKS 306

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217355436  323 ILPHRAR-SRPDLMDNYLALILSAFIRNGLLEGLVEVI-TNSDDHISVRATILLGELLHMANTI 384
Cdd:pfam14664  307 ILPSESSfSRENLVNHYLALLLLVFIEAGLLEALVEVIeESSDSSLSRKATLLLGELLHLANRL 370
RICTOR_phospho pfam14665
Rapamycin-insensitive companion of mTOR, phosphorylation-site; Rictor appears to serve as a ...
 1032-1135 8.19e-45

Rapamycin-insensitive companion of mTOR, phosphorylation-site; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient- and growth-factor signalling. This short region is the phoshorylation site. Rictor does interact with 14-3-3 in a Thr1135-dependent manner. Rictor can be inhibited by short-term rapamycin treatment showing that Thr1135 is an mTORC1-regulated site.


Pssm-ID: 464247  Cd Length: 108  Bit Score: 157.72  E-value: 8.19e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217355436 1032 FPFFASSKLVKNRILNSLTLPNKKHRSSSDPKGGKLSSESKTSNRRIRTLTEPSVDFNHSDDFTPISTVQKTLQ---LET 1108
Cdd:pfam14665    2 FTFLSSSRVVRNRFLNSLTLPKKKLRSSSDPKGGKSSSNKKSGLRRNRTVTEPSSDDNHSGDFFPPVFRVPKSPtqsLET 81

                           90       100
                   ....*....|....*....|....*..
gi 2217355436 1109 SFMGNKHIEDTGSTPSIGENDLKFTKN 1135
Cdd:pfam14665   82 SFVGSKIEEDGGSTPSIGENDLKLPRL 108
RICTOR_M pfam14666
Rapamycin-insensitive companion of mTOR, middle domain; Rictor appears to serve as a ...
 584-687 2.62e-40

Rapamycin-insensitive companion of mTOR, middle domain; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the more conserved central section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.


Pssm-ID: 464248  Cd Length: 104  Bit Score: 144.53  E-value: 2.62e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217355436  584 SSGMKPERSLQNNGLLTTLSQHYFLFIGTLSCHPHGVKMLEKCSVFQCLLNLCSLKNQDHLLKLTVSSLDYSRDGLARVI 663
Cdd:pfam14666    1 SGITAGDPLFSKQRLETTLSRGYFLFIGVLSSSKNGLKLLEKWNIFTILYHIVELKSRDDLLKLILSSLDYSLDGHPRII 80

                           90       100
                   ....*....|....*....|....
gi 2217355436  664 LSKILTAATDACRLYATKHLRVLL 687
Cdd:pfam14666   81 LSKALTSSSESIRLYATKHLRVLL 104
RasGEF_N_2 pfam14663
Rapamycin-insensitive companion of mTOR RasGEF_N domain; Rictor appears to serve as a ...
 694-800 6.04e-38

Rapamycin-insensitive companion of mTOR RasGEF_N domain; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the more conserved central section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.


Pssm-ID: 464245  Cd Length: 107  Bit Score: 138.11  E-value: 6.04e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217355436  694 FNNWGIELLVTQLHDKNKTISSEALDILDEACEDKANLHALIQMKPALSHLGDKGLLLLLRFLSIPKGFSYLNERGYVAK 773
Cdd:pfam14663    1 FEEWGIELLVTQLYDPSPEVVAAAVDVLYEACDDKENLESLVSLRPSLDHLGEIGSPLLLRFLSTPSGFKYLNELGFVEN 80

                           90       100
                   ....*....|....*....|....*..
gi 2217355436  774 QLEKWHREYNSKYVDLIEEQLNEALTT 800
Cdd:pfam14663   81 ELDKWFEERNLEYVLKVEEFLAEALTD 107
RICTOR_V pfam14668
Rapamycin-insensitive companion of mTOR, domain 5; Rictor appears to serve as a scaffolding ...
 869-938 6.74e-34

Rapamycin-insensitive companion of mTOR, domain 5; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. These long eukaryotic proteins carry several well-conserved domains, and this is No.5.


Pssm-ID: 464249  Cd Length: 71  Bit Score: 124.88  E-value: 6.74e-34
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217355436  869 KLKASLWALGNIGSSNWGLNLLQEENVIPDILKLAKQCEVLSIRGTCVYVLGLIAKTKQGCDILKCHNWD 938
Cdd:pfam14668    2 KLKAALWAIGHIGSSPLGIQLLEEYDIVEDIVKIAEESPVLSLRGTAFYVLGLISSTEEGAEILDELGWE 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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