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Conserved domains on  [gi|2217352318|ref|XP_047272237|]
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solute carrier family 49 member A3 isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 157-403 1.05e-106

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17399:

Pssm-ID: 475125  Cd Length: 419  Bit Score: 324.99  E-value: 1.05e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 157 LGVYTIPAGVVCLLSTICLWESVPPTPPSAGAASStSEKFLDGLKlQLMWNKAYVILAVCLGGMIGISASFSALLEQILC 236
Cdd:cd17399   170 LSIYTIPALIAVVLATFGVRSSVPPTPPSASAAHE-SEPFFVGLK-QLFKNKQYLILMLCFGGGIGLFNALSTLLEQILC 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 237 ASGHSSGFSGLCGALFITFGILGALALGPYVDRTKHFTEATKIGLCLFSLACVPFALVSQLQGQTLALAATCSLLGLFGF 316
Cdd:cd17399   248 PSGYSNNFAGICGALMIGVGLIGAFVAGLIVDKTKKFIEVTKVCFCLAVIFLVAFLVVSRFPNQSVLLAVLCGLFGFFGF 327

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 317 SVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTALTVRRSEPSL-----STCQQGEDPLDWTVSLLLMAGL 391
Cdd:cd17399   328 AIYPVGLELAVECTYPVAEATSTGLIFMSGQIQGIILVFIMQALATPLSVYDLpiqcaSSASGNITPLDWTVPLLVMAGL 407

                         250
                  ....*....|..
gi 2217352318 392 CTFFSCILAVFF 403
Cdd:cd17399   408 AAVLAIIFVVFF 419
PHA03381 super family cl31824
tegument protein VP22; Provisional
 413-518 5.35e-04

tegument protein VP22; Provisional


The actual alignment was detected with superfamily member PHA03381:

Pssm-ID: 177618 [Multi-domain]  Cd Length: 290  Bit Score: 41.92  E-value: 5.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 413 ESGEPPSTRNAVGGAD-SGPGVDRGGAGRAGVLGPSTATPECTARGAslEDPRGPGSPH---PACHRATPRAQGPAATdA 488
Cdd:PHA03381   83 RPADPRPSRRPHAQPEaSGPGPARGARGPAGSRGRGRRAESPSPRDP--PNPKGASAPRgrkSACADSAALLDAPAPA-A 159

                          90       100       110
                  ....*....|....*....|....*....|
gi 2217352318 489 PSRPGRLAGRVQASRFidpAGSHSSFSSPW 518
Cdd:PHA03381  160 PKRQKTPAGLARKLHF---STAPTSPTAPW 186
 
Name Accession Description Interval E-value
MFS_MFSD7 cd17399
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily ...
 157-403 1.05e-106

Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily domain-containing protein 7 (MFSD7) is also called myosin light polypeptide 5 regulatory protein (MYL5). It's function is unknown. It is encoded by the a SLC49A3 gene and is a member of the Solute carrier 49 (SLC49) family, which also includes feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1), FLVCR2 (SLC49A2), as well as disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. MFSD7 belongs to the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340957  Cd Length: 419  Bit Score: 324.99  E-value: 1.05e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 157 LGVYTIPAGVVCLLSTICLWESVPPTPPSAGAASStSEKFLDGLKlQLMWNKAYVILAVCLGGMIGISASFSALLEQILC 236
Cdd:cd17399   170 LSIYTIPALIAVVLATFGVRSSVPPTPPSASAAHE-SEPFFVGLK-QLFKNKQYLILMLCFGGGIGLFNALSTLLEQILC 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 237 ASGHSSGFSGLCGALFITFGILGALALGPYVDRTKHFTEATKIGLCLFSLACVPFALVSQLQGQTLALAATCSLLGLFGF 316
Cdd:cd17399   248 PSGYSNNFAGICGALMIGVGLIGAFVAGLIVDKTKKFIEVTKVCFCLAVIFLVAFLVVSRFPNQSVLLAVLCGLFGFFGF 327

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 317 SVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTALTVRRSEPSL-----STCQQGEDPLDWTVSLLLMAGL 391
Cdd:cd17399   328 AIYPVGLELAVECTYPVAEATSTGLIFMSGQIQGIILVFIMQALATPLSVYDLpiqcaSSASGNITPLDWTVPLLVMAGL 407

                         250
                  ....*....|..
gi 2217352318 392 CTFFSCILAVFF 403
Cdd:cd17399   408 AAVLAIIFVVFF 419
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
164-348 9.38e-09

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 57.29  E-value: 9.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 164 AGVVCLLSTICLWESVPPTPPSAGAASSTSEKFLdgLKLQLMWNkAYVILAVCLGGMIGISASFSALLEQILcasGHSSG 243
Cdd:COG2814   170 NAVLALLALLLLLRLLPESRPAARARLRGSLREL--LRRPRLLL-LLLLAFLLGFGFFALFTYLPLYLQEVL---GLSAS 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 244 FSGLCGALFITFGILGALALGPYVDRTKHFTeATKIGLCLFSLACVPFALVSQLqgqtLALAATCSLLGLFGFSVGPVAM 323
Cdd:COG2814   244 AAGLLLALFGLGGVLGALLAGRLADRFGRRR-LLLIGLLLLALGLLLLALAGSL----WLLLLALFLLGFGFGLLFPLLQ 318

                         170       180
                  ....*....|....*....|....*
gi 2217352318 324 ELAVECSFPVGEGAATGMIFVLGQA 348
Cdd:COG2814   319 ALVAELAPPEARGRASGLYNSAFFL 343
PHA03381 PHA03381
tegument protein VP22; Provisional
 413-518 5.35e-04

tegument protein VP22; Provisional


Pssm-ID: 177618 [Multi-domain]  Cd Length: 290  Bit Score: 41.92  E-value: 5.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 413 ESGEPPSTRNAVGGAD-SGPGVDRGGAGRAGVLGPSTATPECTARGAslEDPRGPGSPH---PACHRATPRAQGPAATdA 488
Cdd:PHA03381   83 RPADPRPSRRPHAQPEaSGPGPARGARGPAGSRGRGRRAESPSPRDP--PNPKGASAPRgrkSACADSAALLDAPAPA-A 159

                          90       100       110
                  ....*....|....*....|....*....|
gi 2217352318 489 PSRPGRLAGRVQASRFidpAGSHSSFSSPW 518
Cdd:PHA03381  160 PKRQKTPAGLARKLHF---STAPTSPTAPW 186
 
Name Accession Description Interval E-value
MFS_MFSD7 cd17399
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily ...
 157-403 1.05e-106

Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily domain-containing protein 7 (MFSD7) is also called myosin light polypeptide 5 regulatory protein (MYL5). It's function is unknown. It is encoded by the a SLC49A3 gene and is a member of the Solute carrier 49 (SLC49) family, which also includes feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1), FLVCR2 (SLC49A2), as well as disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. MFSD7 belongs to the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340957  Cd Length: 419  Bit Score: 324.99  E-value: 1.05e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 157 LGVYTIPAGVVCLLSTICLWESVPPTPPSAGAASStSEKFLDGLKlQLMWNKAYVILAVCLGGMIGISASFSALLEQILC 236
Cdd:cd17399   170 LSIYTIPALIAVVLATFGVRSSVPPTPPSASAAHE-SEPFFVGLK-QLFKNKQYLILMLCFGGGIGLFNALSTLLEQILC 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 237 ASGHSSGFSGLCGALFITFGILGALALGPYVDRTKHFTEATKIGLCLFSLACVPFALVSQLQGQTLALAATCSLLGLFGF 316
Cdd:cd17399   248 PSGYSNNFAGICGALMIGVGLIGAFVAGLIVDKTKKFIEVTKVCFCLAVIFLVAFLVVSRFPNQSVLLAVLCGLFGFFGF 327

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 317 SVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTALTVRRSEPSL-----STCQQGEDPLDWTVSLLLMAGL 391
Cdd:cd17399   328 AIYPVGLELAVECTYPVAEATSTGLIFMSGQIQGIILVFIMQALATPLSVYDLpiqcaSSASGNITPLDWTVPLLVMAGL 407

                         250
                  ....*....|..
gi 2217352318 392 CTFFSCILAVFF 403
Cdd:cd17399   408 AAVLAIIFVVFF 419
MFS_SLC49 cd17334
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ...
 157-403 1.15e-79

Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340892 [Multi-domain]  Cd Length: 407  Bit Score: 254.63  E-value: 1.15e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 157 LGVYTIPAGVVCLLSTICLWESVPPTPPSAGAASSTSEK------FLDGLKLQLMWNKAYVILAVCLGGMIGISASFSAL 230
Cdd:cd17334   167 GAVFYGEFGFACLLLALVLALFPPKPKYPPSAASARQQNsehvilELQKSISELLRNEPFVLLAVAFSIMMGVFAGFSSV 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 231 LEQILCASGHSSGFSGLCGALFITFGILGALALGPYVDRTKHFTEATKIGLCLFSLACVPFALVSQ---LQGQTLALAAT 307
Cdd:cd17334   247 LAQILLPFGVSQTSAGWLGFFGIVAGMVGGLLLGLFVDRTRMFKLIGLIILALGTVVCTFFMLLVDrygLPYVTLAFYLL 326

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 308 CSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTALTVrrsepslstcqqgedPLDWTVSLLL 387
Cdd:cd17334   327 CGLLGFFQNSMVPIMFELAVELTYPVPESVSTGVLTALANLFSFLLMLVFSELLG---------------PTPTESKYLL 391

                         250
                  ....*....|....*.
gi 2217352318 388 MAGLCTFFSCILAVFF 403
Cdd:cd17334   392 WFILCTVGSCLGALFF 407
MFS_FLVCR_like cd17398
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ...
 166-360 1.10e-20

Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340956 [Multi-domain]  Cd Length: 406  Bit Score: 94.23  E-value: 1.10e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 166 VVCLLSTICLWESVPPTPPSAGAASSTSEK-----FLDGLKlQLMWNKAYVILAVCLGGMIGISASFSALLEQ-ILCASG 239
Cdd:cd17398   180 TALFILVIIFFKEKPPIPPSRAQAAAQELRsedqsYLGSLK-RLFKNKGFLLLLITYGINTGVYYAISTLLNQmVLEYFP 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 240 HSSGFSGLCGALFITFGILGALALGPYVDRTKHFTEATkIGLCLFSLACVPFALVSQLQGQTLALAATCSLLGLFGFSVG 319
Cdd:cd17398   259 NEEVNAGWIGLTLVIAGLVGSVVAGIWLDKTKKYKETT-IIVYILSFIGMVAFTFTLDLGSIWVVFLTAGALGFFMTGYL 337

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2217352318 320 PVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTAL 360
Cdd:cd17398   338 PVGFEFAAELTYPEPEGTSSGLLNASAQIFGIIFTLVMGAL 378
MFS_DIRC2 cd17397
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; ...
 166-358 9.56e-17

Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; Disrupted in renal carcinoma protein 2 or disrupted in renal cancer protein 2 (DIRC2), encoded by the SLC49A4 gene, was initially identified as a breakpoint-spanning gene in a chromosomal translocation associated with the development of renal cancer. It is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. DIRC2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340955 [Multi-domain]  Cd Length: 381  Bit Score: 81.96  E-value: 9.56e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 166 VVCLLSTICLWESVPPTPPSAgAASSTSEKFLDGLkLQLMWNKAYVILAVCLGGMIGISASFSALLEQILCASGHSSGFS 245
Cdd:cd17397   165 ALIFLAMLIYFPSKPPTPPSV-SASTQRLSYKSGI-LSLLKNKRFWLIALAYGIPTGVYAGWSGVLDVNLTPFGVSQVEA 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 246 GLCGALFITFGILGALALGPYVDRTKHFTEatKIGLCLFSLACVPFALVSQLQ-----GQTLALAATCSLLGLFGFSVGP 320
Cdd:cd17397   243 GWIGFYSTVAGCVGGIIVGRFADRFGGRMK--LILLLLFSGATGSFLWFTLIClkllpFSTVSLYTSCILLGVFLNGSVP 320

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2217352318 321 VAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMT 358
Cdd:cd17397   321 LFYELAVEAAYPVPEGITSGVLTFLNNVFGLVFLLILI 358
MFS_FLVCR1 cd17455
Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator ...
 161-361 7.99e-12

Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 1 (FLVCR1) is also called feline leukemia virus subgroup C receptor (FLVCR). FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. Mutations in the FLVCR1 gene have been linked to vision impairment, posterior column ataxia, and sensory neurodegeneration with loss of pain perception. FLVCR1 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341013  Cd Length: 407  Bit Score: 67.16  E-value: 7.99e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 161 TIPAGVVCLLSTICLWESVPPTPPSAGAA---SSTSEKFLDGLKL-QLMWNKAYVILAVCLGGMIGISASFSALLEQILC 236
Cdd:cd17455   176 TAAVSTLLFILTIIVFKEKPPLPPSQAQAvlqGIPSEDYSYKQSIiNLFKNVPFVLLLISYGIMTGTFYSVSTLLNQMII 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 237 AsgHSSG---FSGLCGALFITFGILGALALGPYVDRTKHFTEATKIGLCLFSLACVPFALVSQLqGQTLALAATCSLLGL 313
Cdd:cd17455   256 T--HYEGeevNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVVFTFTLDL-GYLIVVFVTGGVLGF 332

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2217352318 314 FGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTALT 361
Cdd:cd17455   333 FMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGIIFTLIQGKLT 380
MFS_FLVCR2 cd17456
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator ...
 159-356 1.91e-10

Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 2 (FLVCR2) is also called calcium-chelate transporter (CCT). It functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. Mutations in the FLVCR2 gene cause Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH), also known as Fowler syndrome, a rare autosomal recessive disorder characterized by glomerular vasculopathy in the central nervous system, severe hydrocephaly, hypokinesia and arthrogryphosis. FLVCR2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341014  Cd Length: 406  Bit Score: 62.88  E-value: 1.91e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 159 VYTIPAGVVCLLS--TICLWESVPPTPPS---AGAASSTSEKF-LDGLKLQLMWNKAYVILAVCLGGMIGISASFSALLE 232
Cdd:cd17456   171 MFYGTAAVATLLFilVIIVFQEKPKIPPSqaqAAIQSIPSQDYsYLQSILRLLKNVNFILLVVSYGLNTGCFYALSTLLN 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 233 QILCAsgHSSG---FSGLCGALFITFGILGALALGPYVDRTKHFTEATkIGLCLFSLA-CVPFALVSQLqGQTLALAATC 308
Cdd:cd17456   251 RMVIF--HYPGeevNAGRIGLTIVVAGMVGALISGIWLDRTKTYKQTT-LAVYIMSLVgMVVYTFTLNL-GHLWVVFITA 326

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2217352318 309 SLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLA 356
Cdd:cd17456   327 GTLGFFMTGYLPLGFEFAAELTYPESEGTSSGLLNVSAQVFGIIFTIS 374
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
164-348 9.38e-09

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 57.29  E-value: 9.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 164 AGVVCLLSTICLWESVPPTPPSAGAASSTSEKFLdgLKLQLMWNkAYVILAVCLGGMIGISASFSALLEQILcasGHSSG 243
Cdd:COG2814   170 NAVLALLALLLLLRLLPESRPAARARLRGSLREL--LRRPRLLL-LLLLAFLLGFGFFALFTYLPLYLQEVL---GLSAS 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 244 FSGLCGALFITFGILGALALGPYVDRTKHFTeATKIGLCLFSLACVPFALVSQLqgqtLALAATCSLLGLFGFSVGPVAM 323
Cdd:COG2814   244 AAGLLLALFGLGGVLGALLAGRLADRFGRRR-LLLIGLLLLALGLLLLALAGSL----WLLLLALFLLGFGFGLLFPLLQ 318

                         170       180
                  ....*....|....*....|....*
gi 2217352318 324 ELAVECSFPVGEGAATGMIFVLGQA 348
Cdd:COG2814   319 ALVAELAPPEARGRASGLYNSAFFL 343
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
164-413 1.78e-07

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 53.35  E-value: 1.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 164 AGVVCLLSTICLWESVPPTPPSAGAASSTSEK-FLDGLKLQLMWnKAYVILAVCLGGMIGISASFSALLEQILcasGHSS 242
Cdd:COG2223   165 LGILLLVVAVLAWLFLRDPPAGAAAAAKASLRdQLEALRDPRFW-LLSLLYFGTFGSFIGFSSWLPPYLVDQF---GLSA 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 243 GFSGLCGALFITFGILGALALGPYVDRTKhfteATKIGLCLFSLACVPFALVSQLQGQTLALAATCSLLGLF-GFSVGPV 321
Cdd:COG2223   241 ATAGLLAALFALLGALGRPLGGWLSDRIG----GRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLAlGGGNGAV 316

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 322 AMELAVecSFPVGE-GAATGMIFVLGQAEGILIMLAMTALTVRRSepslstcqqgedplDWTVSLLLMAGLCtFFSCILA 400
Cdd:COG2223   317 FALVPD--IFPTKNaGAVYGLVGAAGGLGGFLGPLLFGALLDATG--------------SYTAAFLVFAVLA-LVALVLT 379

                         250
                  ....*....|...
gi 2217352318 401 VFFHTPYRRLQAE 413
Cdd:COG2223   380 LLLYRRPRRAAAA 392
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 164-363 4.30e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 52.04  E-value: 4.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 164 AGVVCLLSTICLWESVPPTPPSAGAASSTSEKFLDGLKLQLMW-NKAYVILAVCLGGMIGISASFSALLEQILCASGHSS 242
Cdd:cd06174   158 AAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLkNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLS 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 243 G-FSGLCGALFITFGILGALALGPYVDRtkHFTEATKIGLCLFSLACVPFALVsqLQGQTLALAATCSLLGLFGFSVGPV 321
Cdd:cd06174   238 VaVAGLLLSLFGLAGALGSLLLGLLSDR--LIGRKPLLLIGLLLMALGLALLL--LAPSLLLLLLLLLLLGFGLGGLLPL 313

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 2217352318 322 AMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTALTVR 363
Cdd:cd06174   314 SFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAA 355
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
209-409 1.77e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 50.25  E-value: 1.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 209 AYVILAVCLGGMIGISASFSALLEQILcasGHSSGFSGLCGALFITFGILGALALGPYVDRtkhFTEATKIGLCLFSLAC 288
Cdd:COG2271   185 LALAYFLVYFALYGFLTWLPTYLVEVR---GLSLAQAGLLLSLPFLAGIVGSLLGGWLSDR---LGRRRKLVLAIGLLLA 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 289 VPFALVSQLQGQTLALAATCSLLGLFGFSVGPVAMELAVECsFPVGE-GAATGMIFVLGQAEGILIMLAMTALTvrrsep 367
Cdd:COG2271   259 ALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAEL-FPKKArGTASGLVNTFGFLGGALGPLLVGYLL------ 331

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 2217352318 368 slstcqqgeDPLDWTVSLLLMAGLCtFFSCILAVFFHTPYRR 409
Cdd:COG2271   332 ---------DATGYQAAFLLLAALA-LLAALLALLLLRETRK 363
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
153-346 2.83e-06

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 49.49  E-value: 2.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 153 WSRRLGVYTIPAGVVCLLSTICLWESVPPTPPSAGAASSTSekfldglklqLMWNKAYVILAVCLGGMIGISASFSALLE 232
Cdd:COG2807   170 WRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRS----------LWRSPLAWLLTLFFGLQSLLYYAVVAWLP 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 233 QILCASGHSSGFSGLCGALFITFGILGALALGPYVDRTKHfteatKIGLCLFSLACVPFALVSQLQGQTLALAATCSLLG 312
Cdd:COG2807   240 PILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGD-----RRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLG 314

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2217352318 313 LFGFSVGPVAMELAVECSFPVGE-GAATGMIFVLG 346
Cdd:COG2807   315 LGQGGLFPLALTLIGLRARTPAEaAALSGMAQSVG 349
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
160-323 3.32e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 46.43  E-value: 3.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 160 YTIPAGVVCLLSTICLW-------ESVPPTPPSAGaasstsekFLDGLKlQLMWNKAYVIL-AVCLGGMIGISASFSALL 231
Cdd:COG2211   182 YRLTALIFAVLGLLAFLltffgtkERPVPEEEKVS--------LKESLK-ALLKNRPFLLLlLAYLLFFLALALVAALLL 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 232 ---EQILcasGHSSGFSGLCGALFITFGILGALALGPYVDRT-KHFTeaTKIGLCLFSLACVPFALVSqlQGQTLALAAT 307
Cdd:COG2211   253 yyfKYVL---GLSAALVGLLLALYFLAALLGAPLWPRLAKRFgKKKA--FIIGLLLAALGLLLLFFLG--PGNLWLLLVL 325

                         170
                  ....*....|....*...
gi 2217352318 308 CSLLGLF--GFSVGPVAM 323
Cdd:COG2211   326 AALAGIGlgAILVLPWAM 343
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 213-425 1.29e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 44.34  E-value: 1.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 213 LAVCLGGMIGISASFSALLEQILCASGHSSGFSGLCGALFITFGILGALALGPYVDRTkHFTEATKIGLCLFSLACVPFA 292
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRF-GRRPVLLLGLLLFALGALLFA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 293 LVSQLqgqtLALAATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTALTVRRSepslstc 372
Cdd:cd06174    80 FAPSF----WLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLG------- 148

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2217352318 373 qqgedpLDWTVSLLLMAGLCTFFSCILAVFFHTPYRRLQAESGEPPSTRNAVG 425
Cdd:cd06174   149 ------FGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKL 195
PHA03381 PHA03381
tegument protein VP22; Provisional
 413-518 5.35e-04

tegument protein VP22; Provisional


Pssm-ID: 177618 [Multi-domain]  Cd Length: 290  Bit Score: 41.92  E-value: 5.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 413 ESGEPPSTRNAVGGAD-SGPGVDRGGAGRAGVLGPSTATPECTARGAslEDPRGPGSPH---PACHRATPRAQGPAATdA 488
Cdd:PHA03381   83 RPADPRPSRRPHAQPEaSGPGPARGARGPAGSRGRGRRAESPSPRDP--PNPKGASAPRgrkSACADSAALLDAPAPA-A 159

                          90       100       110
                  ....*....|....*....|....*....|
gi 2217352318 489 PSRPGRLAGRVQASRFidpAGSHSSFSSPW 518
Cdd:PHA03381  160 PKRQKTPAGLARKLHF---STAPTSPTAPW 186
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 164-350 6.64e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 42.15  E-value: 6.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 164 AGVVCLLSTICLWESVPPTPPSAGAASSTSEKFLDGLKLQLMWnKAYVILAVCLGGMIGISASFSALLEQIlcaSGHSSG 243
Cdd:cd17324   159 IAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLLRNPRLR-LAYLITFLLFGGFFALYTYLAPFLTDV---PGFSSS 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 244 FSGLCGALFITFGILGALALGPYVDRTKHFTEATKIGLCLFSLACVPFALvsqlqGQTLALAATCSLLGLFGFSVGPVAM 323
Cdd:cd17324   235 AIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLG-----PSPLLLLVGLVLWGLGFFAAHSALQ 309

                         170       180       190
                  ....*....|....*....|....*....|
gi 2217352318 324 ELAVECSfPVGEGAATGM---IFVLGQAEG 350
Cdd:cd17324   310 TRVLRLA-PEARGLASSLylaAYNLGGALG 338
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 165-354 7.33e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 41.79  E-value: 7.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 165 GVVCLLSTICLWESVPPTPPSAgaaSSTSEKFLDGLKLQLMWNKAYVILAVCLGGMI---GISASFSALLEQILCASGHS 241
Cdd:cd17474   159 AALIPVAFLAILFLLPEPKEKA---KSSSATKLRDLKKALRGRGLLTFLVSAFLYFFlyfAFLTYLPFLLELLYGISPII 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 242 SGFSgLCGALFITfgILGALALGPYVDRTKHFTEATKIGLCLFSLAcvpFALVSQLQGQTLALAATcsllGLFGFSVG-- 319
Cdd:cd17474   236 IGLL-FAGWSVLL--ALGSLFVGRLLKKRFGARRILVIGLLLYALS---LLLLGFVPSLALLLIAI----VLFGLGLGln 305

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2217352318 320 -PVAMELAVECSFPVGEGAAT---GMIFVLGQAEGILIM 354
Cdd:cd17474   306 lPLLTTLVTELAPEEERGTASslyNFVRFLGQAVGPLLF 344
MATE_rft1 cd13130
Rft1-like subfamily of the multidrug and toxic compound extrusion family (MATE); This ...
 282-407 1.11e-03

Rft1-like subfamily of the multidrug and toxic compound extrusion family (MATE); This eukaryotic family may function as a transporter, shuttling phospholipids, lipopolysaccharides or oligosaccharides from cytoplasmic to the lumenal side of the endoplasmic reticulum. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance.


Pssm-ID: 240535  Cd Length: 441  Bit Score: 41.56  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 282 CLFSLACVPFALVSQ--------LQGQTLALAATCslLGLFGFSVGPVAMELAVecsfpvgegaatgMIFVLGQ-AEGIL 352
Cdd:cd13130   131 CILELLSEPLYILSQnllkfrlrAIVETAATLVRC--LTTFILIVLGTGKEPKV-------------LVFALGQlAYGVC 195

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217352318 353 IMLAM--TALTVRRSEPSLSTCQQGEDPLDWTVSLLLMAGLCTFFSC----------ILAVFFHTPY 407
Cdd:cd13130   196 LFFGYwyYFLQCFVSKKSSLFPLRNSNLMFFDKPTLRMCGLFTIQSFfkhlltegdkIVLVWFDTPY 262
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 164-354 1.28e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 41.02  E-value: 1.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 164 AGVVCLLSTICLWESVPPTPPSAGAASSTSEKFLDGLKLQLMWNKAYVILAVCLGGMIGISASFSAL---LEQILCASgh 240
Cdd:cd17325   156 CAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLplyAAELGGLS-- 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 241 ssgfSGLCGALFITFGILGALA---LGPYVDRTKHFTEATkIGLCLFSLACVPFALVSQLqgqtLALAATCSLLGLFGFS 317
Cdd:cd17325   234 ----PAQIGLLFGAQGLASALSqppAGKLSDRIGRKPLIL-IGLLLSAVALLLLPLATSF----WLLLLLLALLGLGLGL 304

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2217352318 318 VGPVAMELAVECSFPVGEGAATG---MIFVLGQAEGILIM 354
Cdd:cd17325   305 VFPATLALLADIVPPEGRGTAMGlfnTAFSLGMVLGPLLG 344
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 207-356 2.77e-03

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 40.30  E-value: 2.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217352318 207 NKAYVILAVC--LGGMIGISASfSALLEQILCASGHSSGFSGLCGALFITFGILGALALGPYVDRTKHFTEATKIGLCLF 284
Cdd:cd06179   261 GRNFALILIVafVEGMIFYSLN-IFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAILAGLLLTKIKHIKWQLVAGFVLF 339

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217352318 285 SLACVPFALVsqlQGQTLALAATCSLLGLFGFSVGPVAMELAVECSFPVGE-GAATGMIF---VLGQAEGILIMLA 356
Cdd:cd06179   340 TAFLALLALI---TPDNKALAIAFSVLAGIGIGGPLVLAIVIVQLSVPPEDiGTASGLLGsarALGGAVGTAIFTS 412
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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