BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201592767  37 FVDVTLACDGHSVKAHKMVLSACSPYFQALFFD-NPCQHPIVIMKDIKWPELKAAVEFMYKGEINVSQEQIGPLLKVAES 115
Cdd:cd18315     1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKEtPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                  ....*
gi 2201592767 116 LKIRG 120
Cdd:cd18315    81 LQIKG 85

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201592767  37 FVDVTLACDGHSVKAHKMVLSACSPYFQALFFD-NPCQHPIVIMKDIKWPELKAAVEFMYKGEINVSQEQIGPLLKVAES 115
Cdd:cd18315     1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKEtPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                  ....*
gi 2201592767 116 LKIRG 120
Cdd:cd18315    81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201592767   39 DVTLACDGHSVKAHKMVLSACSPYFQALFFDNPC--QHPIVIMKDIKWPELKAAVEFMYKGEINVSQEQIGPLLKVAESL 116
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKesDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                   ....*...
gi 2201592767  117 KIRGLADV 124
Cdd:smart00225  81 QIPGLVEL 88

kelch-like protein; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201592767  38 VDVTLACDGHSVKAHKMVLSACSPYFQALFFDNPCQHPIVIMKDIKwpELKAAVEFMYKGEINVSQEQIGPLLKVAESLK 117
Cdd:PHA03098   12 ESIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKENEINLNIDYD--SFNEVIKYIYTGKINITSNNVKDILSIANYLI 89

                  .
gi 2201592767 118 I 118
Cdd:PHA03098   90 I 90

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201592767  37 FVDVTLACDGHSVKAHKMVLSACSPYFQALFFD-NPCQHPIVIMKDIKWPELKAAVEFMYKGEINVSQEQIGPLLKVAES 115
Cdd:cd18315     1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKEtPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                  ....*
gi 2201592767 116 LKIRG 120
Cdd:cd18315    81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201592767   39 DVTLACDGHSVKAHKMVLSACSPYFQALFFDNPC--QHPIVIMKDIKWPELKAAVEFMYKGEINVSQEQIGPLLKVAESL 116
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKesDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                   ....*...
gi 2201592767  117 KIRGLADV 124
Cdd:smart00225  81 QIPGLVEL 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201592767  20 YQTNLTNVFDQLLQSESFVDVTLACDGHSVKAHKMVLSACSPYFQALFFDNPCQHPI--VIMKDIKWPELKAAVEFMYKG 97
Cdd:cd18257     1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENseVEFQCIDETALQAIVEYAYTG 80

                          90       100
                  ....*....|....*....|..
gi 2201592767  98 EINVSQEQIGPLLKVAESLKIR 119
Cdd:cd18257    81 TVFISQATVESLLPAANLLQIK 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201592767  28 FDQL---LQSESFVDVTLACDGHSVKAHKMVLSACSPYFQALFFDNP---CQHPIVIMKDIKWPELKAAVEFMYKGEINV 101
Cdd:cd18293     3 FLQLhrqQNSGVFCDVLLQAEGESVPAHCCVLSACSPYLTERLSSEPppaGQKVVLELQGLKAHTLLKLVDFLYTSELEV 82

                          90       100
                  ....*....|....*....|
gi 2201592767 102 SQEQIGPLLKVAESLKIRGL 121
Cdd:cd18293    83 SSEEAQDVLAAARRLQISEL 102

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201592767  28 FDQLLQSESFVDVTL-ACDGHSVKAHKMVLSACSPYFQALFfdnpCQHPIVIM-KDIKWPELKAAVEFMYKGEINVSQEQ 105
Cdd:cd18299     3 LRNLLHSPSCADVVFiLQGGVRIFAHRIVLAAASSVFADLF----LMMTVVTLdSDITPEAFRRVLEFLYTGVLDENEDD 78

                          90       100
                  ....*....|....*....|.
gi 2201592767 106 IGPLLKVAESLKIRGLADVNS 126
Cdd:cd18299    79 LKELKDAAELLELFDLVMMCT 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201592767  37 FVDVTLACDGHSVKAHKMVLSACSPYFQALFFDNPCQHPI--VIMKDIKWPELKAAVEFMYKGEINVSQEQIGPLLKVAE 114
Cdd:cd18306    18 FCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESIltVKLDGLDPDAVEVLVNYAYTSRLEVPADLVKSVYSAAK 97

                          90
                  ....*....|....*....
gi 2201592767 115 SLKIRGLADVnSEQELTSR 133
Cdd:cd18306    98 KLKMDRVKKA-CGDFLLEK 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201592767  27 VFDQLLQSESFVDVTLACDGHSVKAHKMVLSACSPYFQALFFDNPCQHPI--VIMKDIKWPELKAAVEFMYKGEINVSQE 104
Cdd:cd18339    11 VMNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAkkIEIKDVDGQTLSKLIDYIYTAEIEVTEE 90

                          90
                  ....*....|....
gi 2201592767 105 QIGPLLKVAESLKI 118
Cdd:cd18339    91 NVQVLLPAASLLQL 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201592767  26 NVFDQLLQSESFVDVTLACDGHSVKAHKMVLSACSPYFQALfFDNPCQHPivIMKDIKWPE-----LKAAVEFMYKGEIN 100
Cdd:cd18240     6 NVFNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRAL-FTNGWNET--EKKVYKIPGvspemMELIIEYAYTRTVP 82

                          90       100
                  ....*....|....*....|.
gi 2201592767 101 VSQEQIGPLLKVAESLKIRGL 121
Cdd:cd18240    83 ITAENVEELLPAADQFNIMGI 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201592767  30 QLLQSESFVDVTLACDGHSVKAHKMVLSACSPYFQALFFDNPC--QHPIVIMKDIKWPELKAAVEFMYKG---EINVSQE 104
Cdd:cd18297     5 HYVNNPEMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTeaQTPVIEIPDIRYDIFQLMMQYLYTGgveSLDVAQD 84

                          90
                  ....*....|....*..
gi 2201592767 105 QIGPLLKVAESLKIRGL 121
Cdd:cd18297    85 DALELLRAASFFQLDGL 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201592767  27 VFDQLLQSESF---VDVTLACDGHSVKAHKMVLSACSPYFQALFFDnpcQHPIVIMKDIKWPELKAAVEFMYKGEINVSQ 103
Cdd:cd18206     9 VLEQLNQQRQLgllCDCTFVVDGVDFKAHKAVLAACSEYFRMLFVD---QKDVVHLDISNAAGLGQVLEFMYTAKLSLSP 85

                          90
                  ....*....|....*.
gi 2201592767 104 EQIGPLLKVAESLKIR 119
Cdd:cd18206    86 ENVDDVLAVATFLQMQ 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201592767  33 QSESFVDVTLACDGHSVKAHKMVLSACSPYFQALF--FDNPCQHPIVIMKDIKWPELKAAVEFMYKGEINVSQEQIGPLL 110
Cdd:cd18265    19 RSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFggHLKESRQAVVEIQKVSAAAMEVLLDYMYGGGLRIQEDNVESVL 98

                          90
                  ....*....|...
gi 2201592767 111 KVAESLKIRGLAD 123
Cdd:cd18265    99 EASDLLQVSKLRE 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201592767  28 FDQLLQSESFVDVTLACDGHSVKAHKMVLSACSPYFQALFFDnpcqhPI-------VIMKDIKWPELKAAVEFMYKGEIN 100
Cdd:cd18280     5 FGALLESEEGADVTFNVDGEKFRAHKLVLAARSPVFRSMLFG-----PMreenegeIVIEDVEPPVFKALLHFIYKDELP 79

                  ....*..
gi 2201592767 101 VSQEQIG 107
Cdd:cd18280    80 DDVEPAG 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201592767  16 RWNNYQTNLTNVFDQLLQSESFVDVTLACDGHSVKAHKMVLSACSPYFQALFfdnpcqhpIVIMKDIKWPE--------- 86
Cdd:cd18266     4 RWADHSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMF--------TIGMREAHQKEvelvgasyi 75

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2201592767  87 -LKAAVEFMYKGEINVSQEQIGPLLKVAESLKIRGLAD 123
Cdd:cd18266    76 gLKAVIDFLYSSELPLDGGNIDYVLETAHLLQIWKVVD 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201592767  39 DVTLACDGHSVKAHKMVLSACSPYFQALFFDNPC---QHPIViMKDIKWPELKAAVEFMYKGEINVSQEQIGPLLKVAES 115
Cdd:cd18234     3 DVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVReatEEEIK-LKDVDPDALWTLVQYCYTGRLELKEDNVESLLATACL 81

                  ...
gi 2201592767 116 LKI 118
Cdd:cd18234    82 LQL 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201592767  21 QTNLTNVFDQLLQSESFVDVTLACDGHSVKAHKMVLSACSPYFQALFFDN--PCQHPIVIMKDIKWPELKAAVEFMYKGE 98
Cdd:cd18269    11 QTLLQDGLKDLLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDleESKKKEVVLEDVDPDVMGMILKYLYTSE 90

                          90       100
                  ....*....|....*....|
gi 2201592767  99 INVSQEQIGPLLKVAESLKI 118
Cdd:cd18269    91 IDLNDQNVQDIFALASRFQI 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201592767  20 YQTNL-TNVFDQLLQSESFVDVTLACDGHSVKAHKMVLSACSPYFQALFF--DNPCQHPIVIMKDIKWPELKAAVEFMYK 96
Cdd:cd18341     9 YQSTLlQDGLKELLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLseESEEKKKEVVLDNVDPNIMDMILKYLYS 88

                          90       100
                  ....*....|....*....|..
gi 2201592767  97 GEINVSQEQIGPLLKVAESLKI 118
Cdd:cd18341    89 AEIDLNDGNVQDIFALASRFQI 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201592767  28 FDQLLQSESFVDVTLACDGHSVKAHKMVLSACSPYFQALFFDNPC---QHPIVImKDIKWPELKAAVEFMYKGEINVSqe 104
Cdd:cd18287    13 IGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMResqQSEIEL-KDTNAEAFKALLKYIYTGRLTLT-- 89

                          90
                  ....*....|....*...
gi 2201592767 105 qigpLLKVAESLKIRGLA 122
Cdd:cd18287    90 ----DLKEDVLLDVLGLA 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201592767  23 NLTNVFDQLLQSESFVDVTLACDGHSVKAHKMVLSACSPYFQALFFDNPCQHPI--VIMKDIKWPELKAAVEFMYKGEIN 100
Cdd:cd18250     7 HLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRAdrVVLHGVSAEILGLLLDFSYTGRVT 86

                          90
                  ....*....|....
gi 2201592767 101 VSQEQIGPLLKVAE 114
Cdd:cd18250    87 VTQDNVEALLRAAD 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201592767  22 TNLTNVFDQLLQSESFVDVTLACDGHSVKAHKMVLSACSPYFQALFFDN--PCQHPIVIMKDIKWPELKAAVEFMYKGEI 99
Cdd:cd18253     3 ESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDhrESREMLVEINGILAEAMDCFLQYVYTGKV 82

                          90       100
                  ....*....|....*....|....
gi 2201592767 100 NVSQEQIGPLLKVAESLKIRGLAD 123
Cdd:cd18253    83 KITTENVQYLFETSSLFQISPLRD 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201592767  32 LQSESFVDVTLACDGHSVKAHKMVLSACSPYFQALFFDN--PCQHPIVIMKDIKWPELKAAVEFMYKGEINVSQEQIGPL 109
Cdd:cd18336    14 LQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDvrEAKQEEIKMEGVDPDALKALVHYAYTGVLELKEDTIESL 93

                          90
                  ....*....|....*
gi 2201592767 110 LKVAESLKIRGLADV 124
Cdd:cd18336    94 LAAACLLQLSQVIDV 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201592767  27 VFDQLLQSESFVDVTLACDGHSVK----AHKMVLSACSPYFQALFFDN--PCQHPIVIMKDIKWPELKAAVEFMYKGEIN 100
Cdd:cd18248    11 IMNELRLSQQLCDVTLKVKYQDPKeefmAHKVVLASSSPYFKAMFTSGlrECGMEVVPIEGVHPCVMSRLIEFAYTASIS 90

                  ...
gi 2201592767 101 VSQ 103
Cdd:cd18248    91 VGE 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201592767  37 FVDVTLACDGHSVKAHKMVLSACSPYFQALFFDNPCQHP----IVIMKDIKWPELKAAVEFMYKGEINVSQEQIGPLLKV 112
Cdd:cd18245    14 LCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDgstyKIELEGISVEVMEEILDYIYTGQIKLSEDNIQDIVQA 93

                          90
                  ....*....|.
gi 2201592767 113 AESLKIRGLAD 123
Cdd:cd18245    94 ADLLLMTDLKD 104

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201592767  30 QLLQSESFVDVTLACDGHSVKAHKMVLSACSPYFQALFFDN--PCQHPIVIMKDIKWPELKAAVEFMYKGEINVSQEQ-I 106
Cdd:cd18286    10 QLFLNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSwaESNSSEITLTGVSHAAVSFVLLFIYGGVLDLPDDVnL 89

                          90
                  ....*....|....*...
gi 2201592767 107 GPLLKVAESLKIRGLADV 124
Cdd:cd18286    90 GELLSLADMYGLDGLKDV 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201592767  39 DVTLACDGHSVKAHKMVLSACSPYFQALFFDNPCQHPIVIMKDIK-WPELKAAVEFMYKGEINVSQEQIGPLLKVAESLK 117
Cdd:cd18233    20 DCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNSSSQKNDVFHLDIKnVGGIGQILDFMYTSHLDLNQDNVQVMLDIAQCLQ 99

                  .
gi 2201592767 118 I 118
Cdd:cd18233   100 V 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201592767  30 QLLQSESFVDVTLACDGHSVKAHKMVLSACSPYFQALF----FDNPCQHPIVIMKDikwPELKAAVE----FMYKGEINV 101
Cdd:cd18292    10 QLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLsndwWSESKQSEIELVED---PECAAVFEkflrYLYTGQISV 86

                          90       100
                  ....*....|....*....|...
gi 2201592767 102 SQEQIGPLLKVAESLKIRGLADV 124
Cdd:cd18292    87 NLETALPLLMLADKYNVTDLKQL 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201592767  37 FVDVTLACDGHSVKAHKMVLSACSPYFQALFFDNPCQH--PIVIMKDIKWPELKAAVEFMYKGEINVSQEQIGPLLKVAE 114
Cdd:cd18259    32 LSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESisARVEIKDVDPAVMESLIDFAYTGKLTINQGNVEALIRTSN 111

                  ..
gi 2201592767 115 SL 116
Cdd:cd18259   112 RL 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201592767  37 FVDVTLACDGHSVKAHKMVLSACSPYFQALfFDNPCQHPI---VIMKDIKWPE-LKAAVEFMYKGEINVSQEQIGPLLKV 112
Cdd:cd18254    22 FTDVTLWAGNRSFPCHRAVLAACSRYFEAM-FSNGLRESLdstVNFHDSLHPEvLELLLDFAYSSRIIINEENAESLLEA 100

                          90
                  ....*....|....*
gi 2201592767 113 AESLKIRGLADVNSE 127
Cdd:cd18254   101 GDMLQFHDVRDAAAE 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201592767  26 NVFDQLLQSESFVDVTLACDGHSVKAHKMVLSACSPYFQALFFDN--PCQHPIVIMKDIKWPELKAAVEFMYKGEINVSQ 103
Cdd:cd18272    21 SIMDLCLEDGLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNlkEARNRVIELKDVSESVFQLLVDYIYHGTVKLRV 100

                          90
                  ....*....|....*...
gi 2201592767 104 EQIGPLLKVAESLKIRGL 121
Cdd:cd18272   101 EELQETYEVADMYQLTAL 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2201592767  20 YQTNLTNVFDQLLQSESFVDVTLACDGHSVKAHKMVLSACSPYFQALFFD--NPCQHPIVIMKDIKWPELKAAVEFMYKG 97
Cdd:cd18270     9 YAVSLLEQLKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSglSESKQTHVHLRNVDAATLQIIITYAYTG 88