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Conserved domains on  [gi|2092275541|ref|XP_043399479|]
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lysocardiolipin acyltransferase 1 isoform X4 [Chelonia mydas]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 10870651)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0016746|GO:0008654|GO:0006644
PubMed:  18287005|18931347|18718904|37611890
SCOP:  4003349

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 1-124 7.75e-56

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


:

Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 177.43  E-value: 7.75e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092275541   1 MQVAAFIFIQRKWEDDKNHFENMLDYFCDIREPLQLLIFPEGTDLTANTKARSNEFAEKNGLRKYKYVLHPRTTGFTFVV 80
Cdd:cd07990    72 WQLGEFIFLKRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNGLPPLKHVLLPRTKGFVAIL 151

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2092275541  81 ERLREGNnlDAIHDITVAYPQNIPQTEKHLLNGNFPKEIHFHVH 124
Cdd:cd07990   152 ETLRDAV--DAVYDVTIAYPDGKPPSEQRLLLGGKPREVHVHVR 193
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 109-183 3.31e-17

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


:

Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 73.76  E-value: 3.31e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2092275541 109 HLLNGnFPKEIHFHVHRYPVQTLPTSREELQLWCQKRWEEKEERLQLFYEgEKYFDVTGRSIIPPCKSELRVLVV 183
Cdd:pfam16076   1 SLLNG-KPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYE-TGTFFPGKEHIIPRRLKSLLVFIF 73
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 1-124 7.75e-56

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 177.43  E-value: 7.75e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092275541   1 MQVAAFIFIQRKWEDDKNHFENMLDYFCDIREPLQLLIFPEGTDLTANTKARSNEFAEKNGLRKYKYVLHPRTTGFTFVV 80
Cdd:cd07990    72 WQLGEFIFLKRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNGLPPLKHVLLPRTKGFVAIL 151

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2092275541  81 ERLREGNnlDAIHDITVAYPQNIPQTEKHLLNGNFPKEIHFHVH 124
Cdd:cd07990   152 ETLRDAV--DAVYDVTIAYPDGKPPSEQRLLLGGKPREVHVHVR 193
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 6-157 1.60e-35

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 129.82  E-value: 1.60e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092275541   6 FIFIQRKWEDDKNHFENMLDYFCDIREPLQLLIFPEGTDLTANTKARSNEFAEKNGLRKYKYVLHPRTTGFTFVVERLRe 85
Cdd:PLN02510  145 FIPVERKWEVDEPNIRQMLSSFKDPRDPLWLALFPEGTDYTEAKCQRSQKFAAEHGLPILNNVLLPKTKGFVSCLQELR- 223

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2092275541  86 gNNLDAIHDITVAYPQNIPQtekhLLNGNF---PKEIHFHVHRYPVQTLPTSREELQLWCQKRWEEKEERLQLFY 157
Cdd:PLN02510  224 -CSLDAVYDVTIGYKHRCPS----FLDNVFgidPSEVHIHIRRIPLKQIPTSEDEVSAWLMDRFQLKDQLLSDFY 293
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 109-183 3.31e-17

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 73.76  E-value: 3.31e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2092275541 109 HLLNGnFPKEIHFHVHRYPVQTLPTSREELQLWCQKRWEEKEERLQLFYEgEKYFDVTGRSIIPPCKSELRVLVV 183
Cdd:pfam16076   1 SLLNG-KPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYE-TGTFFPGKEHIIPRRLKSLLVFIF 73
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 1-77 1.23e-03

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 37.72  E-value: 1.23e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2092275541    1 MQVAAFIFIQRKWEDDKNHfeNMLDYFCDIREPLQLLIFPEGTDLTANTKARSNEFAEKNGLrKYKYVLHPRTTGFT 77
Cdd:smart00563  45 LRLLGAIFIDRSNGRKARA--ALREAVELLKEGEWLLIFPEGTRSRPGKLLPFKKGAARLAL-EAGVPIVPVAIRGT 118
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 1-124 7.75e-56

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 177.43  E-value: 7.75e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092275541   1 MQVAAFIFIQRKWEDDKNHFENMLDYFCDIREPLQLLIFPEGTDLTANTKARSNEFAEKNGLRKYKYVLHPRTTGFTFVV 80
Cdd:cd07990    72 WQLGEFIFLKRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNGLPPLKHVLLPRTKGFVAIL 151

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2092275541  81 ERLREGNnlDAIHDITVAYPQNIPQTEKHLLNGNFPKEIHFHVH 124
Cdd:cd07990   152 ETLRDAV--DAVYDVTIAYPDGKPPSEQRLLLGGKPREVHVHVR 193
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 6-157 1.60e-35

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 129.82  E-value: 1.60e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092275541   6 FIFIQRKWEDDKNHFENMLDYFCDIREPLQLLIFPEGTDLTANTKARSNEFAEKNGLRKYKYVLHPRTTGFTFVVERLRe 85
Cdd:PLN02510  145 FIPVERKWEVDEPNIRQMLSSFKDPRDPLWLALFPEGTDYTEAKCQRSQKFAAEHGLPILNNVLLPKTKGFVSCLQELR- 223

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2092275541  86 gNNLDAIHDITVAYPQNIPQtekhLLNGNF---PKEIHFHVHRYPVQTLPTSREELQLWCQKRWEEKEERLQLFY 157
Cdd:PLN02510  224 -CSLDAVYDVTIGYKHRCPS----FLDNVFgidPSEVHIHIRRIPLKQIPTSEDEVSAWLMDRFQLKDQLLSDFY 293
PLN02380 PLN02380
1-acyl-sn-glycerol-3-phosphate acyltransferase
 1-194 1.04e-26

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178006 [Multi-domain]  Cd Length: 376  Bit Score: 106.36  E-value: 1.04e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092275541   1 MQVAAFIFIQRKWEDDKNHFENMLDYFCDIREPLQLLIFPEGTDLTANTKARSNEFAEKNGLRKYKYVLHPRTTGFTFVV 80
Cdd:PLN02380  132 MWFSEYVFLERSWAKDENTLKSGFQRLKDFPRPFWLALFVEGTRFTQAKLLAAQEYAASRGLPVPRNVLIPRTKGFVSAV 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092275541  81 ERLREgnNLDAIHDITVAYPQNIPQ-TEKHLLNGNfPKEIHFHVHRYPVQTLPTSREELQLWCQKRWEEKEERLQLF--- 156
Cdd:PLN02380  212 SNMRS--FVPAIYDVTVAVPKGQPApTMLRIFRGQ-SSVVHVHIKRHSMKELPETDDGIAQWCKDVFVAKDALLDKHfae 288

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 2092275541 157 --YEGEKYFDVtGRsiipPCKSELRVLVVKC------ISLLYWTLF 194
Cdd:PLN02380  289 dtFGDQEYQDI-GR----PKKSLIVVISWACllilgaIKFLQWLSL 329
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 109-183 3.31e-17

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 73.76  E-value: 3.31e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2092275541 109 HLLNGnFPKEIHFHVHRYPVQTLPTSREELQLWCQKRWEEKEERLQLFYEgEKYFDVTGRSIIPPCKSELRVLVV 183
Cdd:pfam16076   1 SLLNG-KPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYE-TGTFFPGKEHIIPRRLKSLLVFIF 73
PRK14014 PRK14014
putative acyltransferase; Provisional
 39-154 5.35e-10

putative acyltransferase; Provisional


Pssm-ID: 237584 [Multi-domain]  Cd Length: 301  Bit Score: 58.32  E-value: 5.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092275541  39 FPEGTDLTANTKARSNEfaeknglrKYKYVLHPRTTGFTFVVERLreGNNLDAIHDITVAYPQNIPqTEKHLLNGNfPKE 118
Cdd:PRK14014  180 FVEGTRFTPEKHQQQQS--------PYQHLLKPKAGGIAFALNAM--GEQFDGLLDVTIVYPDGRP-SFWDLLSGR-VKK 247

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2092275541 119 IHFHVHRYPV--------QTLPTSREELQLWCQKRWEEKEERLQ 154
Cdd:PRK14014  248 IVVHVRLLPIpeeligdyFNDKEFRRRFQQWLNQLWQEKDQLIE 291
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 6-123 7.08e-04

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 39.32  E-value: 7.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2092275541   6 FIFIQRKWEDDKNHF-ENMLDYFCDIREplQLLIFPEGTdltantkaRSNEfaEKNGLRKYKYVLHP-RTTGFTFVVERL 83
Cdd:cd06551    75 AFSVDRDSPRSAAKSlKYVARLLSKPGS--VVWIFPEGT--------RTRR--DKRPLQFKPGVAHLaEKAGVPIVPVAL 142

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2092275541  84 REGNNL-DAIHDITVAYPQNIPQTEKH---LLNGNFPKEIHFHV 123
Cdd:cd06551   143 RYTFELfEQFPEIFVRIGPPIPYAETAlgeELAAELANRLTRLL 186
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 1-77 1.23e-03

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 37.72  E-value: 1.23e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2092275541    1 MQVAAFIFIQRKWEDDKNHfeNMLDYFCDIREPLQLLIFPEGTDLTANTKARSNEFAEKNGLrKYKYVLHPRTTGFT 77
Cdd:smart00563  45 LRLLGAIFIDRSNGRKARA--ALREAVELLKEGEWLLIFPEGTRSRPGKLLPFKKGAARLAL-EAGVPIVPVAIRGT 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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