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Conserved domains on  [gi|2048025509|ref|XP_041800788|]
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transcription factor COE1-A isoform X3 [Chelmon rostratus]

Protein Classification

transcription factor COE( domain architecture ID 11242836)

transcription factor COE similar to human COE1 and COE2 that recognize variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3, and may play roles in B-cell development

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COE1_DBD pfam16422
Transcription factor COE1 DNA-binding domain;
23-247 6.80e-173

Transcription factor COE1 DNA-binding domain;


:

Pssm-ID: 435333  Cd Length: 227  Bit Score: 488.97  E-value: 6.80e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048025509  23 GMNAVRTWMQGAGVLDANTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTTFVDFVEKEKETTGE 102
Cdd:pfam16422   3 SMNSVRNWMQCAGVLDASVAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFIDFVEKEKEPEDE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048025509 103 KTNNGIHYRLQLLYSNGIRTEQDLYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVI 182
Cdd:pfam16422  83 KTNNGIHYRLQLLYSNGIRTEQDLYVRLIDSVTKQAIVYEGQDKNPEMCRVLLTHEVMCSRCCDKKSCGNRNETPSDPVI 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2048025509 183 IDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVSVEGHVLAVSDNMFVHNNSKHGRRARRL 247
Cdd:pfam16422 163 IDRFFLKFFMKCNQNCLKNAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSKHGRRARRL 227
IPT_COE cd01175
IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing ...
 262-346 1.63e-55

IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved in the regulation of the early stages of B-cell differentiation, Drosophila collier is a regulator of the head patterning, and a related protein in Xenopus is involved in primary neurogenesis. All COE family members have a well conserved DNA binding domain that contains an atypical Zn finger motif. The function of the IPT domain is unknown.


:

Pssm-ID: 238580  Cd Length: 85  Bit Score: 182.08  E-value: 1.63e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048025509 262 PSIKAISPSEGWTTGGATVIIIGDNFFDGLQVIFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGR 341
Cdd:cd01175     1 PCIKAISPSEGWTTGGATVIIIGDNFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGR 80


                  ....*
gi 2048025509 342 FIYTA 346
Cdd:cd01175    81 FVYTA 85
COE1_HLH pfam16423
Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of ...
 347-390 1.84e-25

Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of transcription factor COE1. It is responsible for dimerization.


:

Pssm-ID: 406751  Cd Length: 44  Bit Score: 98.71  E-value: 1.84e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2048025509 347 LNEPTIDYGFQRLQKVIPRHPGDQERLPKEVILKRAADLVEALY 390
Cdd:pfam16423   1 LNEPTIDYGFQRLQKLVPRHPGDPERLPKEIILKRAADLAEALY 44
 
Name Accession Description Interval E-value
COE1_DBD pfam16422
Transcription factor COE1 DNA-binding domain;
23-247 6.80e-173

Transcription factor COE1 DNA-binding domain;


Pssm-ID: 435333  Cd Length: 227  Bit Score: 488.97  E-value: 6.80e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048025509  23 GMNAVRTWMQGAGVLDANTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTTFVDFVEKEKETTGE 102
Cdd:pfam16422   3 SMNSVRNWMQCAGVLDASVAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFIDFVEKEKEPEDE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048025509 103 KTNNGIHYRLQLLYSNGIRTEQDLYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVI 182
Cdd:pfam16422  83 KTNNGIHYRLQLLYSNGIRTEQDLYVRLIDSVTKQAIVYEGQDKNPEMCRVLLTHEVMCSRCCDKKSCGNRNETPSDPVI 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2048025509 183 IDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVSVEGHVLAVSDNMFVHNNSKHGRRARRL 247
Cdd:pfam16422 163 IDRFFLKFFMKCNQNCLKNAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSKHGRRARRL 227
COE_DBD cd11606
Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain; COE_DBD is the amino-terminal DNA ...
 35-247 5.32e-165

Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain; COE_DBD is the amino-terminal DNA binding domain of the COE protein family. The COE transcription factor is a regulator of development in several organs and tissues that contain the DBD domain as well as IPT/TIG (immunoglobulin-like, Plexins, transcription factors/transcription factor immunoglobulin) and basic helix-loop-helix (bHLH) domains. COE has four members in mammals (COE1-4) with high sequence similarity at the amino-terminal region. COE_DBD requires a zinc ion to bind DNA and contains a zinc finger motif (H-X(3)-C-X(2)-C-X(5)-C) termed the zinc knuckle. COE is homo- or heterodimerized through the bHLH domain to bind DNA. COE1-4 each has a variant due to alternative splicing. However, this alternative splicing does not occur at the DBD domain.


Pssm-ID: 212156  Cd Length: 212  Bit Score: 468.07  E-value: 5.32e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048025509  35 GVLDAnTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTTFVDFVEKEKETTGEKTNNGIHYRLQL 114
Cdd:cd11606     1 GVTDP-SAAQTSVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPIEVERTAFVDFVEKEREQGGEKTNNGIHYRLQL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048025509 115 LYSNGIRTEQDLYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKC 194
Cdd:cd11606    80 LYSNGIRTEQDLYVRLIDSSTKQAIPYEGQDKNPEMCRVLLTHEIMCSRCCEKKSCGNRNETPSDPVIIDRFFLKFFLKC 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2048025509 195 NQNCLKNAGNPRDMRRFQVVVSTTVSVEGHVLAVSDNMFVHNNSKHGRRARRL 247
Cdd:cd11606   160 NQNCLKNAGNPRDMRRFQVVLSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRL 212
IPT_COE cd01175
IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing ...
 262-346 1.63e-55

IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved in the regulation of the early stages of B-cell differentiation, Drosophila collier is a regulator of the head patterning, and a related protein in Xenopus is involved in primary neurogenesis. All COE family members have a well conserved DNA binding domain that contains an atypical Zn finger motif. The function of the IPT domain is unknown.


Pssm-ID: 238580  Cd Length: 85  Bit Score: 182.08  E-value: 1.63e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048025509 262 PSIKAISPSEGWTTGGATVIIIGDNFFDGLQVIFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGR 341
Cdd:cd01175     1 PCIKAISPSEGWTTGGATVIIIGDNFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGR 80


                  ....*
gi 2048025509 342 FIYTA 346
Cdd:cd01175    81 FVYTA 85
COE1_HLH pfam16423
Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of ...
 347-390 1.84e-25

Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of transcription factor COE1. It is responsible for dimerization.


Pssm-ID: 406751  Cd Length: 44  Bit Score: 98.71  E-value: 1.84e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2048025509 347 LNEPTIDYGFQRLQKVIPRHPGDQERLPKEVILKRAADLVEALY 390
Cdd:pfam16423   1 LNEPTIDYGFQRLQKLVPRHPGDPERLPKEIILKRAADLAEALY 44
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 262-344 3.04e-15

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 70.94  E-value: 3.04e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048025509 262 PSIKAISPSEGWTTGGATVIIIGDNF---FDGLQVIFGTMLVWSELITPHAIRVQTPPrHIPGVVEVTLSYKSKQFCKGt 338
Cdd:pfam01833   1 PVITSISPSSGPASGGTTITITGSNFgtdSSDLKVTIGGTPCTVISVSSTTIVCTTPP-GTSGLVNVSVTVGGGGISSS- 78


                  ....*.
gi 2048025509 339 PGRFIY 344
Cdd:pfam01833  79 PLTFTY 84
IPT smart00429
ig-like, plexins, transcription factors;
262-345 9.77e-08

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 49.73  E-value: 9.77e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048025509  262 PSIKAISPSEGWTTGGATVIIIGDNFFDGlQVIFGTMLVWSELIT-----PHAIRVQTPPRH-IPGVVEV-TLSYKSKQF 334
Cdd:smart00429   2 PVITRISPTSGPVSGGTEITLCGKNLKSI-SVVFVEVGVGEAPCTfspssSTAIVCKTPPYHnIPGSVPVrTVGLRNGGV 80

                           90
                   ....*....|.
gi 2048025509  335 cKGTPGRFIYT 345
Cdd:smart00429  81 -PSSPQPFTYV 90
HLH smart00353
helix loop helix domain;
352-392 2.75e-04

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 39.12  E-value: 2.75e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2048025509  352 IDYGFQRLQKVIPRHPGDQeRLPKEVILKRAADLVEALYGM 392
Cdd:smart00353  11 INEAFDELRSLLPTLPKNK-KLSKAEILRLAIEYIKSLQEE 50
 
Name Accession Description Interval E-value
COE1_DBD pfam16422
Transcription factor COE1 DNA-binding domain;
23-247 6.80e-173

Transcription factor COE1 DNA-binding domain;


Pssm-ID: 435333  Cd Length: 227  Bit Score: 488.97  E-value: 6.80e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048025509  23 GMNAVRTWMQGAGVLDANTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTTFVDFVEKEKETTGE 102
Cdd:pfam16422   3 SMNSVRNWMQCAGVLDASVAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFIDFVEKEKEPEDE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048025509 103 KTNNGIHYRLQLLYSNGIRTEQDLYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVI 182
Cdd:pfam16422  83 KTNNGIHYRLQLLYSNGIRTEQDLYVRLIDSVTKQAIVYEGQDKNPEMCRVLLTHEVMCSRCCDKKSCGNRNETPSDPVI 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2048025509 183 IDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVSVEGHVLAVSDNMFVHNNSKHGRRARRL 247
Cdd:pfam16422 163 IDRFFLKFFMKCNQNCLKNAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSKHGRRARRL 227
COE_DBD cd11606
Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain; COE_DBD is the amino-terminal DNA ...
 35-247 5.32e-165

Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain; COE_DBD is the amino-terminal DNA binding domain of the COE protein family. The COE transcription factor is a regulator of development in several organs and tissues that contain the DBD domain as well as IPT/TIG (immunoglobulin-like, Plexins, transcription factors/transcription factor immunoglobulin) and basic helix-loop-helix (bHLH) domains. COE has four members in mammals (COE1-4) with high sequence similarity at the amino-terminal region. COE_DBD requires a zinc ion to bind DNA and contains a zinc finger motif (H-X(3)-C-X(2)-C-X(5)-C) termed the zinc knuckle. COE is homo- or heterodimerized through the bHLH domain to bind DNA. COE1-4 each has a variant due to alternative splicing. However, this alternative splicing does not occur at the DBD domain.


Pssm-ID: 212156  Cd Length: 212  Bit Score: 468.07  E-value: 5.32e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048025509  35 GVLDAnTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTTFVDFVEKEKETTGEKTNNGIHYRLQL 114
Cdd:cd11606     1 GVTDP-SAAQTSVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPIEVERTAFVDFVEKEREQGGEKTNNGIHYRLQL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048025509 115 LYSNGIRTEQDLYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKC 194
Cdd:cd11606    80 LYSNGIRTEQDLYVRLIDSSTKQAIPYEGQDKNPEMCRVLLTHEIMCSRCCEKKSCGNRNETPSDPVIIDRFFLKFFLKC 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2048025509 195 NQNCLKNAGNPRDMRRFQVVVSTTVSVEGHVLAVSDNMFVHNNSKHGRRARRL 247
Cdd:cd11606   160 NQNCLKNAGNPRDMRRFQVVLSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRL 212
IPT_COE cd01175
IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing ...
 262-346 1.63e-55

IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved in the regulation of the early stages of B-cell differentiation, Drosophila collier is a regulator of the head patterning, and a related protein in Xenopus is involved in primary neurogenesis. All COE family members have a well conserved DNA binding domain that contains an atypical Zn finger motif. The function of the IPT domain is unknown.


Pssm-ID: 238580  Cd Length: 85  Bit Score: 182.08  E-value: 1.63e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048025509 262 PSIKAISPSEGWTTGGATVIIIGDNFFDGLQVIFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGR 341
Cdd:cd01175     1 PCIKAISPSEGWTTGGATVIIIGDNFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGR 80


                  ....*
gi 2048025509 342 FIYTA 346
Cdd:cd01175    81 FVYTA 85
COE1_HLH pfam16423
Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of ...
 347-390 1.84e-25

Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of transcription factor COE1. It is responsible for dimerization.


Pssm-ID: 406751  Cd Length: 44  Bit Score: 98.71  E-value: 1.84e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2048025509 347 LNEPTIDYGFQRLQKVIPRHPGDQERLPKEVILKRAADLVEALY 390
Cdd:pfam16423   1 LNEPTIDYGFQRLQKLVPRHPGDPERLPKEIILKRAADLAEALY 44
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 262-344 3.04e-15

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 70.94  E-value: 3.04e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048025509 262 PSIKAISPSEGWTTGGATVIIIGDNF---FDGLQVIFGTMLVWSELITPHAIRVQTPPrHIPGVVEVTLSYKSKQFCKGt 338
Cdd:pfam01833   1 PVITSISPSSGPASGGTTITITGSNFgtdSSDLKVTIGGTPCTVISVSSTTIVCTTPP-GTSGLVNVSVTVGGGGISSS- 78


                  ....*.
gi 2048025509 339 PGRFIY 344
Cdd:pfam01833  79 PLTFTY 84
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 262-345 1.06e-12

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 64.02  E-value: 1.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048025509 262 PSIKAISPSEGWTTGGATVIIIGDNFFDG--LQVIFGTMLVWSEL-ITPHAIRVQTPPRHI--PGVVEVTLSYKSkQFCK 336
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGsnLRVTFGGGVPCSVLsVSSTAIVCTTPPYANpgPGPVEVTVDRGN-GGIT 79


                  ....*....
gi 2048025509 337 GTPGRFIYT 345
Cdd:cd00102    80 SSPLTFTYV 88
IPT smart00429
ig-like, plexins, transcription factors;
262-345 9.77e-08

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 49.73  E-value: 9.77e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048025509  262 PSIKAISPSEGWTTGGATVIIIGDNFFDGlQVIFGTMLVWSELIT-----PHAIRVQTPPRH-IPGVVEV-TLSYKSKQF 334
Cdd:smart00429   2 PVITRISPTSGPVSGGTEITLCGKNLKSI-SVVFVEVGVGEAPCTfspssSTAIVCKTPPYHnIPGSVPVrTVGLRNGGV 80

                           90
                   ....*....|.
gi 2048025509  335 cKGTPGRFIYT 345
Cdd:smart00429  81 -PSSPQPFTYV 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 262-345 6.96e-05

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 41.67  E-value: 6.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048025509 262 PSIKAISPSEGWTTGGATVIIIGDNF---FDGLQVIFGTMLVWSELITPHAIRVQTPPRHIP--GVVEVTLSYKSKQFCK 336
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLgsgSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPgeGPVEVTVDGANVSARV 80


                  ....*....
gi 2048025509 337 GTPGRFIYT 345
Cdd:cd00603    81 LSNTTFTYV 89
IPT_TF cd00602
IPT domain of eukaryotic transcription factors NF-kappaB/Rel, nuclear factor of activated ...
 262-345 1.01e-04

IPT domain of eukaryotic transcription factors NF-kappaB/Rel, nuclear factor of activated Tcells (NFAT), and recombination signal J-kappa binding protein (RBP-Jkappa). The IPT domains in these proteins are involved in DNA binding. Most NF-kappaB/Rel proteins form homo- and heterodimers, while NFAT proteins are largely monomeric (with TonEBP being an exception). While the majority of sequence-specific DNA binding elements are found in the N-terminal domain, several are found in the IPT domain in loops adjacent to, and including, the linker region.


Pssm-ID: 238336  Cd Length: 101  Bit Score: 41.50  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048025509 262 PSIKAISPSEGWTTGGATVIIIGDNF-FDGLQVIFG----TMLVW-------SELITPHAIRVQTPPRHIPGV-----VE 324
Cdd:cd00602     1 LPICRVSSLSGSVNGGDEVFLLCDKVnKPDIKVWFGekgpGETVWeaeamfrQEDVRQVAIVFKTPPYHNKWItrpvqVP 80

                          90       100
                  ....*....|....*....|.
gi 2048025509 325 VTLSYKSKQfCKGTPGRFIYT 345
Cdd:cd00602    81 IQLVRPDDR-KRSEPLTFTYT 100
HLH smart00353
helix loop helix domain;
352-392 2.75e-04

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 39.12  E-value: 2.75e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2048025509  352 IDYGFQRLQKVIPRHPGDQeRLPKEVILKRAADLVEALYGM 392
Cdd:smart00353  11 INEAFDELRSLLPTLPKNK-KLSKAEILRLAIEYIKSLQEE 50
IPT_NFAT cd01178
IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a ...
 262-346 5.34e-03

IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.


Pssm-ID: 238583  Cd Length: 101  Bit Score: 36.69  E-value: 5.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048025509 262 PSIKAISPSEGWTTGGATVIIIGDNFFDGLQVIF-----GTMLVWS-------ELITPHAIRVQTPPRHIPGV---VEVT 326
Cdd:cd01178     2 PEIEKKSLNSCSVNGGEELFLTGKNFLKDSKVVFqekgqDGEAQWEaeatidkEKSHQNHLVVEVPPYHNKHVaapVQVQ 81

                          90       100
                  ....*....|....*....|
gi 2048025509 327 LSYKSKQFCKGTPGRFIYTA 346
Cdd:cd01178    82 FYVVNGKRKRSQPQTFTYTP 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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