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Conserved domains on  [gi|2024349190|ref|XP_040563034|]
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kelch domain-containing protein 4 isoform X4 [Gallus gallus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
26-219 2.05e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 79.04  E-value: 2.05e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024349190  26 GRSGHRMVACKRQLIIFGGFHESARDYIYYNDVYAFNLDSFTWSKLAPSgigPAPRSGCQmATTPEGSIVIYGGYSKQRV 105
Cdd:COG3055    60 PRHHAAAVAQDGKLYVFGGFTGANPSSTPLNDVYVYDPATNTWTKLAPM---PTPRGGAT-ALLLDGKIYVVGGWDDGGN 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024349190 106 KKDVDKGTLHTDmfllktegsgkeedkwVWSRLNPSgvkPTPRSGFSVAIGPNNRSLLFGGVHDEEEEES---------- 175
Cdd:COG3055   136 VAWVEVYDPATG----------------TWTQLAPL---PTPRDHLAAAVLPDGKILVIGGRNGSGFSNTwttlaplpta 196

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024349190 176 -----------------IEGDFFNDIYFYDTGKNRWFP-GQLKVPksekrkRRRGRQAETDG 219
Cdd:COG3055   197 raghaaavlggkilvfgGESGFSDEVEAYDPATNTWTAlGELPTP------RHGHAAVLTDG 252
DUF4110 super family cl16271
Domain of unknown function (DUF4110); This is a family that is found predominantly at the ...
 376-429 7.92e-03

Domain of unknown function (DUF4110); This is a family that is found predominantly at the C-terminus of Kelch-containing proteins. However, the exact function of this region is not known.


The actual alignment was detected with superfamily member pfam13422:

Pssm-ID: 463871  Cd Length: 95  Bit Score: 35.74  E-value: 7.92e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2024349190 376 QHPsvQPDEKHADYLSRTEQYWIKVARSNM----GPDAKEKKVVKVAHAMAKTFYEDS 429
Cdd:pfam13422   8 PTP--RPFESLRDFFARTSAEWQEIAIESLrdkgSTSHSGKELKKEAFDLAEERYWEL 63
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
26-219 2.05e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 79.04  E-value: 2.05e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024349190  26 GRSGHRMVACKRQLIIFGGFHESARDYIYYNDVYAFNLDSFTWSKLAPSgigPAPRSGCQmATTPEGSIVIYGGYSKQRV 105
Cdd:COG3055    60 PRHHAAAVAQDGKLYVFGGFTGANPSSTPLNDVYVYDPATNTWTKLAPM---PTPRGGAT-ALLLDGKIYVVGGWDDGGN 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024349190 106 KKDVDKGTLHTDmfllktegsgkeedkwVWSRLNPSgvkPTPRSGFSVAIGPNNRSLLFGGVHDEEEEES---------- 175
Cdd:COG3055   136 VAWVEVYDPATG----------------TWTQLAPL---PTPRDHLAAAVLPDGKILVIGGRNGSGFSNTwttlaplpta 196

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024349190 176 -----------------IEGDFFNDIYFYDTGKNRWFP-GQLKVPksekrkRRRGRQAETDG 219
Cdd:COG3055   197 raghaaavlggkilvfgGESGFSDEVEAYDPATNTWTAlGELPTP------RHGHAAVLTDG 252
PLN02193 PLN02193
nitrile-specifier protein
 29-166 1.33e-07

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 53.42  E-value: 1.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024349190  29 GHRMVACKRQLIIFGGFHESARdyiyYNDVYAFNLDSFTWSKLAPSGIGPAPRSGCQMATTPEgSIVIYGGYS-KQRVK- 106
Cdd:PLN02193  221 GVRMVSIGSTLYVFGGRDASRQ----YNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAADEE-NVYVFGGVSaTARLKt 295

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024349190 107 ----KDVDKGTLHT----DMFLLKTeGSGKE--------------------------EDKwvWSRLNPSGVKPTPRSGF- 151
Cdd:PLN02193  296 ldsyNIVDKKWFHCstpgDSFSIRG-GAGLEvvqgkvwvvygfngcevddvhyydpvQDK--WTQVETFGVRPSERSVFa 372

                         170
                  ....*....|....*
gi 2024349190 152 SVAIGpnNRSLLFGG 166
Cdd:PLN02193  373 SAAVG--KHIVIFGG 385
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 24-66 5.10e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 42.94  E-value: 5.10e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2024349190  24 PSGRSGHRMVACKRQLIIFGGFheSARDYIYYNDVYAFNLDSF 66
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGY--TGGEGQPSDDVYVLSLPTF 41
DUF4110 pfam13422
Domain of unknown function (DUF4110); This is a family that is found predominantly at the ...
 376-429 7.92e-03

Domain of unknown function (DUF4110); This is a family that is found predominantly at the C-terminus of Kelch-containing proteins. However, the exact function of this region is not known.


Pssm-ID: 463871  Cd Length: 95  Bit Score: 35.74  E-value: 7.92e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2024349190 376 QHPsvQPDEKHADYLSRTEQYWIKVARSNM----GPDAKEKKVVKVAHAMAKTFYEDS 429
Cdd:pfam13422   8 PTP--RPFESLRDFFARTSAEWQEIAIESLrdkgSTSHSGKELKKEAFDLAEERYWEL 63
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
26-219 2.05e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 79.04  E-value: 2.05e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024349190  26 GRSGHRMVACKRQLIIFGGFHESARDYIYYNDVYAFNLDSFTWSKLAPSgigPAPRSGCQmATTPEGSIVIYGGYSKQRV 105
Cdd:COG3055    60 PRHHAAAVAQDGKLYVFGGFTGANPSSTPLNDVYVYDPATNTWTKLAPM---PTPRGGAT-ALLLDGKIYVVGGWDDGGN 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024349190 106 KKDVDKGTLHTDmfllktegsgkeedkwVWSRLNPSgvkPTPRSGFSVAIGPNNRSLLFGGVHDEEEEES---------- 175
Cdd:COG3055   136 VAWVEVYDPATG----------------TWTQLAPL---PTPRDHLAAAVLPDGKILVIGGRNGSGFSNTwttlaplpta 196

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024349190 176 -----------------IEGDFFNDIYFYDTGKNRWFP-GQLKVPksekrkRRRGRQAETDG 219
Cdd:COG3055   197 raghaaavlggkilvfgGESGFSDEVEAYDPATNTWTAlGELPTP------RHGHAAVLTDG 252
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
24-194 4.99e-09

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 57.09  E-value: 4.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024349190  24 PSGRSGHRMVACKRQLIIFGGFHESArdyiYYNDVYAFNLDSFTWSKLAPsgiGPAPRSGCQMATTPEGSIVIYGGYSkq 103
Cdd:COG3055    10 PTPRSEAAAALLDGKVYVAGGLSGGS----ASNSFEVYDPATNTWSELAP---LPGPPRHHAAAVAQDGKLYVFGGFT-- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024349190 104 rvkKDVDKGTLHTDMFLLKTEgsgkeedKWVWSRLNPSgvkPTPRSGfSVAIGPNNRSLLFGGVHDeeeeesieGDFFND 183
Cdd:COG3055    81 ---GANPSSTPLNDVYVYDPA-------TNTWTKLAPM---PTPRGG-ATALLLDGKIYVVGGWDD--------GGNVAW 138

                         170
                  ....*....|.
gi 2024349190 184 IYFYDTGKNRW 194
Cdd:COG3055   139 VEVYDPATGTW 149
PLN02193 PLN02193
nitrile-specifier protein
 29-166 1.33e-07

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 53.42  E-value: 1.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024349190  29 GHRMVACKRQLIIFGGFHESARdyiyYNDVYAFNLDSFTWSKLAPSGIGPAPRSGCQMATTPEgSIVIYGGYS-KQRVK- 106
Cdd:PLN02193  221 GVRMVSIGSTLYVFGGRDASRQ----YNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAADEE-NVYVFGGVSaTARLKt 295

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024349190 107 ----KDVDKGTLHT----DMFLLKTeGSGKE--------------------------EDKwvWSRLNPSGVKPTPRSGF- 151
Cdd:PLN02193  296 ldsyNIVDKKWFHCstpgDSFSIRG-GAGLEvvqgkvwvvygfngcevddvhyydpvQDK--WTQVETFGVRPSERSVFa 372

                         170
                  ....*....|....*
gi 2024349190 152 SVAIGpnNRSLLFGG 166
Cdd:PLN02193  373 SAAVG--KHIVIFGG 385
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 24-66 5.10e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 42.94  E-value: 5.10e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2024349190  24 PSGRSGHRMVACKRQLIIFGGFheSARDYIYYNDVYAFNLDSF 66
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGY--TGGEGQPSDDVYVLSLPTF 41
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
24-103 1.60e-05

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 46.30  E-value: 1.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024349190  24 PSGRSGHRMVACKRQLIIFGGFHEsardyiYYNDVYAFNLDSFTWSKLAPSgigPAPRSGCQMATTpEGSIVIYGGYSKQ 103
Cdd:COG3055   194 PTARAGHAAAVLGGKILVFGGESG------FSDEVEAYDPATNTWTALGEL---PTPRHGHAAVLT-DGKVYVIGGETKP 263
Kelch_4 pfam13418
Galactose oxidase, central domain;
26-74 2.79e-05

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 41.06  E-value: 2.79e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2024349190  26 GRSGHRMVAC-KRQLIIFGGFHEsarDYIYYNDVYAFNLDSFTWSKLAPS 74
Cdd:pfam13418   1 PRAYHTSTSIpDDTIYLFGGEGE---DGTLLSDLWVFDLSTNEWTRLGSL 47
Kelch_3 pfam13415
Galactose oxidase, central domain;
36-87 4.29e-05

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 40.74  E-value: 4.29e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2024349190  36 KRQLIIFGGFHESARDYiyYNDVYAFNLDSFTWSKLAPSgigPAPRSGCQMA 87
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTR--LNDLYVYDLDTNTWTQIGDL---PPPRSGHSAT 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 27-73 2.48e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 38.36  E-value: 2.48e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2024349190  27 RSGHRMVACKRQLIIFGGFHESARDyiyyNDVYAFNLDSFTWSKLAP 73
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSL----NSVEVYDPETNTWSKLPS 44
PRK14131 PRK14131
N-acetylneuraminate epimerase;
22-103 4.85e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 41.92  E-value: 4.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024349190  22 GGPsgRSGHRMVACKRQLIIFGGFHESARD--YIYYNDVYAFNLDSFTWSKL---APSGIgpaprSGCQMATTPEGSIVI 96
Cdd:PRK14131   72 GGP--REQAVAAFIDGKLYVFGGIGKTNSEgsPQVFDDVYKYDPKTNSWQKLdtrSPVGL-----AGHVAVSLHNGKAYI 144


                  ....*..
gi 2024349190  97 YGGYSKQ 103
Cdd:PRK14131  145 TGGVNKN 151
PLN02153 PLN02153
epithiospecifier protein
 22-166 4.24e-03

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 39.20  E-value: 4.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024349190  22 GGPSGRSGHRMVACKRQLIIFGGFHESA--RDYIYYNDVYAFNLDSFTWSKLAPSGIGPAPRSGCQMATTpEGSIVIYGG 99
Cdd:PLN02153  123 GGPEARTFHSMASDENHVYVFGGVSKGGlmKTPERFRTIEAYNIADGKWVQLPDPGENFEKRGGAGFAVV-QGKIWVVYG 201

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024349190 100 YSKQRVKKdvDKGTLHTDMFLLKTEGSGKeedkwvWSRLNPSGVKPTPRSGFSVAIgPNNRSLLFGG 166
Cdd:PLN02153  202 FATSILPG--GKSDYESNAVQFFDPASGK------WTEVETTGAKPSARSVFAHAV-VGKYIIIFGG 259
Kelch_4 pfam13418
Galactose oxidase, central domain;
147-194 5.69e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 34.90  E-value: 5.69e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2024349190 147 PRSGFSVAIGPNNRSLLFGGvhdeeeeESIEGDFFNDIYFYDTGKNRW 194
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGG-------EGEDGTLLSDLWVFDLSTNEW 41
DUF4110 pfam13422
Domain of unknown function (DUF4110); This is a family that is found predominantly at the ...
 376-429 7.92e-03

Domain of unknown function (DUF4110); This is a family that is found predominantly at the C-terminus of Kelch-containing proteins. However, the exact function of this region is not known.


Pssm-ID: 463871  Cd Length: 95  Bit Score: 35.74  E-value: 7.92e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2024349190 376 QHPsvQPDEKHADYLSRTEQYWIKVARSNM----GPDAKEKKVVKVAHAMAKTFYEDS 429
Cdd:pfam13422   8 PTP--RPFESLRDFFARTSAEWQEIAIESLrdkgSTSHSGKELKKEAFDLAEERYWEL 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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