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Conserved domains on  [gi|2023166654|ref|XP_040436922|]
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leukemia inhibitory factor receptor [Falco naumanni]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LIFR_D2 pfam17971
Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding ...
 117-230 2.44e-64

Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding module 1 (CBM1) found in Leukemia inhibitory factor receptor (LIFR) and OSM receptors (OSMR). LIFR has an extracellular region with a modular structure containing two cytokine-binding modules (CBM) separated by an Ig-like domain and followed by three membrane-proximal fibronectin type-III (FNIII) domains. The D2 domain in CBM1 shows structural similarity to the corresponding CBM domains of both gp130 and IL-6Ralpha because it contains conserved structural features like the WSXWS motif. The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation.


:

Pssm-ID: 375455  Cd Length: 114  Bit Score: 212.70  E-value: 2.44e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023166654  117 DISFVPLTPHILSLTPDFSTSTLNLKWSDSGSVFPYGLDAFWQIQILRKEAMEKVIQVTYYSKLTHEDIILSWNWTSDMP 196
Cdd:pfam17971    1 NVSLIPDTPQILNLTADFSTSTLHLKWNDKGSAFPYHSNVIWEIKVLRKEKMEIVTLVTYNTTLNGKDTVHHWNWTSDMP 80

                           90       100       110
                   ....*....|....*....|....*....|....
gi 2023166654  197 LECTSHYVKIRCYINVTQFVGPKDWSDWSPVEEV 230
Cdd:pfam17971   81 LECTSHSVRIRCYIDDVHFSGPKEWSEWSPLKNI 114
LIFR_N pfam18207
Leukemia inhibitory factor receptor N-terminal domain; This domain can be found in leukemia ...
 35-115 2.28e-29

Leukemia inhibitory factor receptor N-terminal domain; This domain can be found in leukemia inhibitory factor receptor (LIFR). LIFR is a cell surface receptor that mediates the actions of LIF and other interleukin-6 type cytokines through the formation of signalling complexes with gp130. This is the N-terminal domain, referred to as domain 1, which contains conserved disulfide bonds between Cys-10 to Cys-20 and Cys-37 to Cys-45.


:

Pssm-ID: 436347  Cd Length: 78  Bit Score: 111.65  E-value: 2.28e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023166654   35 NFKCVTHNLRKMICTWDVSSKGRHGQT-DFCYTTNDlhpPVCFKTKEKRVEIPvPESSSTVTITTNSISGTAFATKEFEI 113
Cdd:pfam18207    1 DLKCITHNLQVWDCSWDAPSGAGHGTTyEFCIENRS---HSCYKTEKTNIEIP-ALSPGDHEITINSLSGFGSSTSKFIL 76


                   ..
gi 2023166654  114 HK 115
Cdd:pfam18207   77 NE 78
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 719-819 2.76e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.72  E-value: 2.76e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023166654  719 NFTVEETSSDSILVKWEdiPIEDCQGFLEGYRLSFakgekdalkprlSESGNPELKVKNITDLTKKSLKILDLQGKTSYQ 798
Cdd:cd00063      6 NLRVTDVTSTSVTLSWT--PPEDDGGPITGYVVEY------------REKGSGDWKEVEVTPGSETSYTLTGLKPGTEYE 71

                           90       100
                   ....*....|....*....|.
gi 2023166654  799 LDLQAYTAGGLSPPNSLYVVT 819
Cdd:cd00063     72 FRVRAVNGGGESPPSESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 422-520 5.52e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.95  E-value: 5.52e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023166654  422 PKTPEKLTVSGNSSTSVRLRW----FINGSFAEIRLLCQIEISSGHYErklhnvsMPGGKFSIYTAQLNALHPYTKYQFR 497
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWtppeDDGGPITGYVVEYREKGSGDWKE-------VEVTPGSETSYTLTGLKPGTEYEFR 73

                           90       100
                   ....*....|....*....|...
gi 2023166654  498 VRCSSADHfwrWSDWSRIEEHTT 520
Cdd:cd00063     74 VRAVNGGG---ESPPSESVTVTT 93
 
Name Accession Description Interval E-value
LIFR_D2 pfam17971
Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding ...
 117-230 2.44e-64

Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding module 1 (CBM1) found in Leukemia inhibitory factor receptor (LIFR) and OSM receptors (OSMR). LIFR has an extracellular region with a modular structure containing two cytokine-binding modules (CBM) separated by an Ig-like domain and followed by three membrane-proximal fibronectin type-III (FNIII) domains. The D2 domain in CBM1 shows structural similarity to the corresponding CBM domains of both gp130 and IL-6Ralpha because it contains conserved structural features like the WSXWS motif. The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation.


Pssm-ID: 375455  Cd Length: 114  Bit Score: 212.70  E-value: 2.44e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023166654  117 DISFVPLTPHILSLTPDFSTSTLNLKWSDSGSVFPYGLDAFWQIQILRKEAMEKVIQVTYYSKLTHEDIILSWNWTSDMP 196
Cdd:pfam17971    1 NVSLIPDTPQILNLTADFSTSTLHLKWNDKGSAFPYHSNVIWEIKVLRKEKMEIVTLVTYNTTLNGKDTVHHWNWTSDMP 80

                           90       100       110
                   ....*....|....*....|....*....|....
gi 2023166654  197 LECTSHYVKIRCYINVTQFVGPKDWSDWSPVEEV 230
Cdd:pfam17971   81 LECTSHSVRIRCYIDDVHFSGPKEWSEWSPLKNI 114
LIFR_N pfam18207
Leukemia inhibitory factor receptor N-terminal domain; This domain can be found in leukemia ...
 35-115 2.28e-29

Leukemia inhibitory factor receptor N-terminal domain; This domain can be found in leukemia inhibitory factor receptor (LIFR). LIFR is a cell surface receptor that mediates the actions of LIF and other interleukin-6 type cytokines through the formation of signalling complexes with gp130. This is the N-terminal domain, referred to as domain 1, which contains conserved disulfide bonds between Cys-10 to Cys-20 and Cys-37 to Cys-45.


Pssm-ID: 436347  Cd Length: 78  Bit Score: 111.65  E-value: 2.28e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023166654   35 NFKCVTHNLRKMICTWDVSSKGRHGQT-DFCYTTNDlhpPVCFKTKEKRVEIPvPESSSTVTITTNSISGTAFATKEFEI 113
Cdd:pfam18207    1 DLKCITHNLQVWDCSWDAPSGAGHGTTyEFCIENRS---HSCYKTEKTNIEIP-ALSPGDHEITINSLSGFGSSTSKFIL 76


                   ..
gi 2023166654  114 HK 115
Cdd:pfam18207   77 NE 78
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 719-819 2.76e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.72  E-value: 2.76e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023166654  719 NFTVEETSSDSILVKWEdiPIEDCQGFLEGYRLSFakgekdalkprlSESGNPELKVKNITDLTKKSLKILDLQGKTSYQ 798
Cdd:cd00063      6 NLRVTDVTSTSVTLSWT--PPEDDGGPITGYVVEY------------REKGSGDWKEVEVTPGSETSYTLTGLKPGTEYE 71

                           90       100
                   ....*....|....*....|.
gi 2023166654  799 LDLQAYTAGGLSPPNSLYVVT 819
Cdd:cd00063     72 FRVRAVNGGGESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
719-812 5.37e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.48  E-value: 5.37e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023166654  719 NFTVEETSSDSILVKWEdiPIEDCQGFLEGYRLsfakgekdalkpRLSESGNPELKVKNITDLTKKSLKILDLQGKTSYQ 798
Cdd:pfam00041    5 NLTVTDVTSTSLTVSWT--PPPDGNGPITGYEV------------EYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYE 70

                           90
                   ....*....|....
gi 2023166654  799 LDLQAYTAGGLSPP 812
Cdd:pfam00041   71 VRVQAVNGGGEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 422-520 5.52e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.95  E-value: 5.52e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023166654  422 PKTPEKLTVSGNSSTSVRLRW----FINGSFAEIRLLCQIEISSGHYErklhnvsMPGGKFSIYTAQLNALHPYTKYQFR 497
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWtppeDDGGPITGYVVEYREKGSGDWKE-------VEVTPGSETSYTLTGLKPGTEYEFR 73

                           90       100
                   ....*....|....*....|...
gi 2023166654  498 VRCSSADHfwrWSDWSRIEEHTT 520
Cdd:cd00063     74 VRAVNGGG---ESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
425-510 1.99e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.94  E-value: 1.99e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023166654  425 PEKLTVSGNSSTSVRLRW----FINGSFAEIRLLCQiEISSGHYERKLHNVSmpggkfSIYTAQLNALHPYTKYQFRVRC 500
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWtpppDGNGPITGYEVEYR-PKNSGEPWNEITVPG------TTTSVTLTGLKPGTEYEVRVQA 75

                           90
                   ....*....|
gi 2023166654  501 SSADHFWRWS 510
Cdd:pfam00041   76 VNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 422-500 4.64e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.91  E-value: 4.64e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023166654   422 PKTPEKLTVSGNSSTSVRLRW---FINGSFAEIrLLCQIEISSGHYERKLHNVSmpggkFSIYTAQLNALHPYTKYQFRV 498
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWeppPDDGITGYI-VGYRVEYREEGSEWKEVNVT-----PSSTSYTLTGLKPGTEYEFRV 74


                    ..
gi 2023166654   499 RC 500
Cdd:smart00060   75 RA 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 714-810 7.96e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.52  E-value: 7.96e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023166654   714 PKRAPNFTVEETSSDSILVKWEDIPIEDCQGFLEGYRLSFakgekdalkprlSESGNPELKVKNITDLTkkSLKILDLQG 793
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEY------------REEGSEWKEVNVTPSST--SYTLTGLKP 66

                            90
                    ....*....|....*..
gi 2023166654   794 KTSYQLDLQAYTAGGLS 810
Cdd:smart00060   67 GTEYEFRVRAVNGAGEG 83
 
Name Accession Description Interval E-value
LIFR_D2 pfam17971
Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding ...
 117-230 2.44e-64

Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding module 1 (CBM1) found in Leukemia inhibitory factor receptor (LIFR) and OSM receptors (OSMR). LIFR has an extracellular region with a modular structure containing two cytokine-binding modules (CBM) separated by an Ig-like domain and followed by three membrane-proximal fibronectin type-III (FNIII) domains. The D2 domain in CBM1 shows structural similarity to the corresponding CBM domains of both gp130 and IL-6Ralpha because it contains conserved structural features like the WSXWS motif. The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation.


Pssm-ID: 375455  Cd Length: 114  Bit Score: 212.70  E-value: 2.44e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023166654  117 DISFVPLTPHILSLTPDFSTSTLNLKWSDSGSVFPYGLDAFWQIQILRKEAMEKVIQVTYYSKLTHEDIILSWNWTSDMP 196
Cdd:pfam17971    1 NVSLIPDTPQILNLTADFSTSTLHLKWNDKGSAFPYHSNVIWEIKVLRKEKMEIVTLVTYNTTLNGKDTVHHWNWTSDMP 80

                           90       100       110
                   ....*....|....*....|....*....|....
gi 2023166654  197 LECTSHYVKIRCYINVTQFVGPKDWSDWSPVEEV 230
Cdd:pfam17971   81 LECTSHSVRIRCYIDDVHFSGPKEWSEWSPLKNI 114
LIFR_N pfam18207
Leukemia inhibitory factor receptor N-terminal domain; This domain can be found in leukemia ...
 35-115 2.28e-29

Leukemia inhibitory factor receptor N-terminal domain; This domain can be found in leukemia inhibitory factor receptor (LIFR). LIFR is a cell surface receptor that mediates the actions of LIF and other interleukin-6 type cytokines through the formation of signalling complexes with gp130. This is the N-terminal domain, referred to as domain 1, which contains conserved disulfide bonds between Cys-10 to Cys-20 and Cys-37 to Cys-45.


Pssm-ID: 436347  Cd Length: 78  Bit Score: 111.65  E-value: 2.28e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023166654   35 NFKCVTHNLRKMICTWDVSSKGRHGQT-DFCYTTNDlhpPVCFKTKEKRVEIPvPESSSTVTITTNSISGTAFATKEFEI 113
Cdd:pfam18207    1 DLKCITHNLQVWDCSWDAPSGAGHGTTyEFCIENRS---HSCYKTEKTNIEIP-ALSPGDHEITINSLSGFGSSTSKFIL 76


                   ..
gi 2023166654  114 HK 115
Cdd:pfam18207   77 NE 78
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 719-819 2.76e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.72  E-value: 2.76e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023166654  719 NFTVEETSSDSILVKWEdiPIEDCQGFLEGYRLSFakgekdalkprlSESGNPELKVKNITDLTKKSLKILDLQGKTSYQ 798
Cdd:cd00063      6 NLRVTDVTSTSVTLSWT--PPEDDGGPITGYVVEY------------REKGSGDWKEVEVTPGSETSYTLTGLKPGTEYE 71

                           90       100
                   ....*....|....*....|.
gi 2023166654  799 LDLQAYTAGGLSPPNSLYVVT 819
Cdd:cd00063     72 FRVRAVNGGGESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
719-812 5.37e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.48  E-value: 5.37e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023166654  719 NFTVEETSSDSILVKWEdiPIEDCQGFLEGYRLsfakgekdalkpRLSESGNPELKVKNITDLTKKSLKILDLQGKTSYQ 798
Cdd:pfam00041    5 NLTVTDVTSTSLTVSWT--PPPDGNGPITGYEV------------EYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYE 70

                           90
                   ....*....|....
gi 2023166654  799 LDLQAYTAGGLSPP 812
Cdd:pfam00041   71 VRVQAVNGGGEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 422-520 5.52e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.95  E-value: 5.52e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023166654  422 PKTPEKLTVSGNSSTSVRLRW----FINGSFAEIRLLCQIEISSGHYErklhnvsMPGGKFSIYTAQLNALHPYTKYQFR 497
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWtppeDDGGPITGYVVEYREKGSGDWKE-------VEVTPGSETSYTLTGLKPGTEYEFR 73

                           90       100
                   ....*....|....*....|...
gi 2023166654  498 VRCSSADHfwrWSDWSRIEEHTT 520
Cdd:cd00063     74 VRAVNGGG---ESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
425-510 1.99e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.94  E-value: 1.99e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023166654  425 PEKLTVSGNSSTSVRLRW----FINGSFAEIRLLCQiEISSGHYERKLHNVSmpggkfSIYTAQLNALHPYTKYQFRVRC 500
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWtpppDGNGPITGYEVEYR-PKNSGEPWNEITVPG------TTTSVTLTGLKPGTEYEVRVQA 75

                           90
                   ....*....|
gi 2023166654  501 SSADHFWRWS 510
Cdd:pfam00041   76 VNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 422-500 4.64e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.91  E-value: 4.64e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023166654   422 PKTPEKLTVSGNSSTSVRLRW---FINGSFAEIrLLCQIEISSGHYERKLHNVSmpggkFSIYTAQLNALHPYTKYQFRV 498
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWeppPDDGITGYI-VGYRVEYREEGSEWKEVNVT-----PSSTSYTLTGLKPGTEYEFRV 74


                    ..
gi 2023166654   499 RC 500
Cdd:smart00060   75 RA 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 714-810 7.96e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.52  E-value: 7.96e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023166654   714 PKRAPNFTVEETSSDSILVKWEDIPIEDCQGFLEGYRLSFakgekdalkprlSESGNPELKVKNITDLTkkSLKILDLQG 793
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEY------------REEGSEWKEVNVTPSST--SYTLTGLKP 66

                            90
                    ....*....|....*..
gi 2023166654   794 KTSYQLDLQAYTAGGLS 810
Cdd:smart00060   67 GTEYEFRVRAVNGAGEG 83
Pur_ac_phosph_N pfam16656
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple ...
 425-512 1.88e-03

Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple acid phosphatase proteins.


Pssm-ID: 465220 [Multi-domain]  Cd Length: 93  Bit Score: 38.54  E-value: 1.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023166654  425 PEKLTVS-GNSSTSVRLRWFINGSFAEIRLlcQIEISSGHYERK-----LHNVSMPGGKFSIYTAQLNALHPYTKYQFRV 498
Cdd:pfam16656    1 PEQVHLSlTGDSTSMTVSWVTPSAVTSPVV--QYGTSSSALTSTatatsSTYTTGDGGTGYIHRATLTGLEPGTTYYYRV 78

                           90
                   ....*....|....
gi 2023166654  499 RCSSAdhfwRWSDW 512
Cdd:pfam16656   79 GDDNG----GWSEV 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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