zinc finger HIT (zf-HIT) found in INO80 complex subunit B (INO80B) and similar proteins; INO80B, also called high mobility group AT-hook 1-like 4 (HMGA1L4), or IES2 homolog, or PAP-1-associated protein 1 (PAPA-1), or zinc finger HIT domain-containing protein 4 (ZNHIT4), is a nucleolar protein that induces growth and cell cycle arrests at the G1 phase of the cell cycle. It is a core component of the chromatin remodeling INO80 complex, which is involved in transcriptional regulation, DNA replication and probably DNA repair. INO80B harbors a zf-HIT domain which is characterized by a fold in "treble-clef" through interleaved CCCC and CCHC ZnF motifs that both bind a zinc atom. The yeast counterpart of INO80B is Ies2p (Ino eighty subunit 2), which doesn't have zf-HIT domain.

                          10        20        30
                  ....*....|....*....|....*....|.
gi 2007643014 329 CGVSGCTNLKKYSCSKTGVPLCSLDCYKRNL 359
Cdd:cd23021     3 CSVPGCTNPKKYRCSKTGVPVCSLECYKKNL 33

cell division protein FtsN;

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2007643014 175 GGPVDEEERW-----LDALEKG-----ELDDNGELKKEvdeSLLTARQKALLHKQQS----QP--LLELPMGYKEKEMTA 238
Cdd:PRK10927   74 GLPPKPEERWryikeLESRQPGvraptEPSAGGEVKTP---EQLTPEQRQLLEQMQAdmrqQPtqLVEVPWNEQTPEQRQ 150

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2007643014 239 EMMQKREERARKRRLQAAKKAEENKNQTIERLTKTSKAKIKSMKEKKSKQ--SQCPmvrYSD 298
Cdd:PRK10927  151 QTLQRQRQAQQLAEQQRLAQQSRTTEQSWQQQTRTSQAAPVQAQPRQSKPasTQQP---YQD 209

zinc finger HIT (zf-HIT) found in INO80 complex subunit B (INO80B) and similar proteins; INO80B, also called high mobility group AT-hook 1-like 4 (HMGA1L4), or IES2 homolog, or PAP-1-associated protein 1 (PAPA-1), or zinc finger HIT domain-containing protein 4 (ZNHIT4), is a nucleolar protein that induces growth and cell cycle arrests at the G1 phase of the cell cycle. It is a core component of the chromatin remodeling INO80 complex, which is involved in transcriptional regulation, DNA replication and probably DNA repair. INO80B harbors a zf-HIT domain which is characterized by a fold in "treble-clef" through interleaved CCCC and CCHC ZnF motifs that both bind a zinc atom. The yeast counterpart of INO80B is Ies2p (Ino eighty subunit 2), which doesn't have zf-HIT domain.

                          10        20        30
                  ....*....|....*....|....*....|.
gi 2007643014 329 CGVSGCTNLKKYSCSKTGVPLCSLDCYKRNL 359
Cdd:cd23021     3 CSVPGCTNPKKYRCSKTGVPVCSLECYKKNL 33

PAPA-1-like conserved region; Family of proteins with a conserved region found in PAPA-1, a PAP-1 binding protein.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2007643014 238 AEMMQkreerarKRRLQAAKKAEENKNQTIERLTKTSKAKIKSMKEK--------KSKQSQCPMVRYSDSAKGMAISFP 308
Cdd:pfam04795   7 AEMAR-------RRKNQSEKRLEEEKAETINKLLKKQAPKRKAAAEAelpeneatEPYRPNPQMIRWVSNPDGTTVSVP 78

zinc finger HIT (zf-HIT) found in INO80 complex subunit B (INO80B) and similar proteins; INO80B, also called high mobility group AT-hook 1-like 4 (HMGA1L4), or IES2 homolog, or PAP-1-associated protein 1 (PAPA-1), or zinc finger HIT domain-containing protein 4 (ZNHIT4), is a nucleolar protein that induces growth and cell cycle arrests at the G1 phase of the cell cycle. It is a core component of the chromatin remodeling INO80 complex, which is involved in transcriptional regulation, DNA replication and probably DNA repair. INO80B harbors a zf-HIT domain which is characterized by a fold in "treble-clef" through interleaved CCCC and CCHC ZnF motifs that both bind a zinc atom. The yeast counterpart of INO80B is Ies2p (Ino eighty subunit 2), which doesn't have zf-HIT domain.

                          10        20        30
                  ....*....|....*....|....*....|.
gi 2007643014 329 CGVSGCTNLKKYSCSKTGVPLCSLDCYKRNL 359
Cdd:cd23021     3 CSVPGCTNPKKYRCSKTGVPVCSLECYKKNL 33

zinc finger HIT (zf-HIT) domain; The zinc finger HIT (zf-HIT) is a novel zinc-binding domain with about 50 amino acids. It is characterized by a fold in "treble-clef" through interleaved CCCC and CCHC zinc finger motifs that both bind a zinc ion. zf-HIT domain may function as a protein-protein interaction domain. It is mainly found in nuclear proteins involved in gene regulation and chromatin remodeling. The zf-HIT family includes six proteins containing zf-HIT domain present in human and three in yeast proteome, all belonging to multimodular RNA/protein complexes.

                          10        20
                  ....*....|....*....|.
gi 2007643014 339 KYSCSKTGVPLCSLDCYKRNL 359
Cdd:cd23020    11 KYKCPRCGVPYCSLECYRKHL 31

zinc finger HIT (zf-HIT) found in zinc finger HIT domain-containing protein 2 (ZNHIT2), 3 (ZNHIT3) and similar proteins; ZNHIT2 and ZNHIT3 are members of the zf-HIT domain-containing protein family that play crucial roles in various biological processes. ZNHIT2 acts as a bridging factor between the R2TP/PFDL complex and U5 snRNP, while ZNHIT3 interacts specifically with the ligand binding domain of the thyroid receptor and is involved in small nucleolar ribonucleoprotein particle assembly, transcriptional regulation, and snoRNP assembly. ZNHIT3 is also associated with HNF-4alpha and may play a role in MODY, while its dysfunction is linked to PEHO syndrome. Both proteins contain the zf-HIT domain and interact with other proteins through their HIT-type zinc finger in the presence of ATP, ADP, or other factors.

                          10        20
                  ....*....|....*....|....*....
gi 2007643014 329 CGVsgC-TNLKKYSCSKTGVPLCSLDCYK 356
Cdd:cd23024     3 CGV--CnKNESKYKCPRCNIPYCSLACYK 29