|
Name |
Accession |
Description |
Interval |
E-value |
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
209-472 |
0e+00 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 573.07 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 209 YVPPPPPDNEEAIFAHYQTGINFDKYDTILVEVSGLDPPPAILTFEEANLCQTLNKNIAKAGYLKLTPVQKYSIPIILAG 288
Cdd:cd18052 1 YIPPPPPEDEDEIFATIQTGINFDKYDEIPVEVTGRNPPPAILTFEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 289 RDLMACAQTGSGKTAAFLLPILAHMMKDGVTASHFREQQEPECIIVAPTRELINQIFLEARKFSYGTCIRPVVIYGGTQT 368
Cdd:cd18052 81 RDLMACAQTGSGKTAAFLLPVLTGMMKEGLTASSFSEVQEPQALIVAPTRELANQIFLEARKFSYGTCIRPVVVYGGVSV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 369 GHSIRQIMQGCNILCATPGRLMDIIGKEKIGLRKVRYLVLDEADRMLDMGFGPEMKKLISCPGMPSKDRRQTLMFSATFP 448
Cdd:cd18052 161 GHQIRQIEKGCHILVATPGRLLDFIGRGKISLSKLKYLILDEADRMLDMGFGPEIRKLVSEPGMPSKEDRQTLMFSATFP 240
|
250 260
....*....|....*....|....
gi 1985382941 449 EEIQRLSGEFLKPEYLFVAVGQVG 472
Cdd:cd18052 241 EEIQRLAAEFLKEDYLFLTVGRVG 264
|
|
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
252-608 |
3.40e-151 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 444.98 E-value: 3.40e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 252 TFEEANLCQTLNKNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMKDGvtashfreQQEPEC 331
Cdd:COG0513 3 SFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDPSR--------PRAPQA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 332 IIVAPTRELINQIFLEARKFSYGTCIRPVVIYGGTQTGHSIRQIMQGCNILCATPGRLMDIIGKEKIGLRKVRYLVLDEA 411
Cdd:COG0513 75 LILAPTRELALQVAEELRKLAKYLGLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIERGALDLSGVETLVLDEA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 412 DRMLDMGFGPEMKKLIS-CPgmpskDRRQTLMFSATFPEEIQRLSGEFLKpEYLFVAVGQVGGACSDVQQTVLQVSQYSK 490
Cdd:COG0513 155 DRMLDMGFIEDIERILKlLP-----KERQTLLFSATMPPEIRKLAKRYLK-NPVRIEVAPENATAETIEQRYYLVDKRDK 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 491 REKLVEILQSIRDERTMVFVETKKKADFIATFLCQEKIPTTSIHGDREQREREEALWDFRSGKCPVLVATSVAARGLDIE 570
Cdd:COG0513 229 LELLRRLLRDEDPERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDID 308
|
330 340 350
....*....|....*....|....*....|....*...
gi 1985382941 571 KVQHVINFDLPSTIDEYVHRIGRTGRCGNIGKAISFFD 608
Cdd:COG0513 309 DVSHVINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVT 346
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
252-472 |
1.15e-142 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 415.35 E-value: 1.15e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 252 TFEEANLCQTLNKNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMKDGVTAS-HFREQQEPE 330
Cdd:cd17967 1 SFEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLLEDGPPSVgRGRRKAYPS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 331 CIIVAPTRELINQIFLEARKFSYGTCIRPVVIYGGTQTGHSIRQIMQGCNILCATPGRLMDIIGKEKIGLRKVRYLVLDE 410
Cdd:cd17967 81 ALILAPTRELAIQIYEEARKFSYRSGVRSVVVYGGADVVHQQLQLLRGCDILVATPGRLVDFIERGRISLSSIKFLVLDE 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1985382941 411 ADRMLDMGFGPEMKKLISCPGMPSKDRRQTLMFSATFPEEIQRLSGEFLKpEYLFVAVGQVG 472
Cdd:cd17967 161 ADRMLDMGFEPQIRKIVEHPDMPPKGERQTLMFSATFPREIQRLAADFLK-NYIFLTVGRVG 221
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
139-651 |
1.54e-117 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 362.94 E-value: 1.54e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 139 RGQQSGNVF-ISRRGGFGGPTGDNGSNRSRGFGSKGGYR-GYNEEViAGSGRSSWKSHGKTESGDNQGP----KVTYVPp 212
Cdd:PTZ00110 11 GSVSSGPSNnYNSYGPYPDSSNPYGNYQANHQDNYGGFRpGYGNYS-GGYGGFGMNSYGSSTLGKRLQPidwkSINLVP- 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 213 pppdNEEAIFAHYQ--TGINFDKYDTILVE-----VSGLDPPPAILTFEEANLCQTLNKNIAKAGYLKLTPVQKYSIPII 285
Cdd:PTZ00110 89 ----FEKNFYKEHPevSALSSKEVDEIRKEkeitiIAGENVPKPVVSFEYTSFPDYILKSLKNAGFTEPTPIQVQGWPIA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 286 LAGRDLMACAQTGSGKTAAFLLPILAHmmkdgVTASH-FREQQEPECIIVAPTRELINQIFLEARKFSYGTCIRPVVIYG 364
Cdd:PTZ00110 165 LSGRDMIGIAETGSGKTLAFLLPAIVH-----INAQPlLRYGDGPIVLVLAPTRELAEQIREQCNKFGASSKIRNTVAYG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 365 GTQTGHSIRQIMQGCNILCATPGRLMDIIGKEKIGLRKVRYLVLDEADRMLDMGFGPEMKKLIScpgmPSKDRRQTLMFS 444
Cdd:PTZ00110 240 GVPKRGQIYALRRGVEILIACPGRLIDFLESNVTNLRRVTYLVLDEADRMLDMGFEPQIRKIVS----QIRPDRQTLMWS 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 445 ATFPEEIQRLSGEFLKPEYLFVAVGQVG-GACSDVQQTVLQVSQYSKREKLVEILQSIRDE--RTMVFVETKKKADFIAT 521
Cdd:PTZ00110 316 ATWPKEVQSLARDLCKEEPVHVNVGSLDlTACHNIKQEVFVVEEHEKRGKLKMLLQRIMRDgdKILIFVETKKGADFLTK 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 522 FLCQEKIPTTSIHGDREQREREEALWDFRSGKCPVLVATSVAARGLDIEKVQHVINFDLPSTIDEYVHRIGRTGRCGNIG 601
Cdd:PTZ00110 396 ELRLDGWPALCIHGDKKQEERTWVLNEFKTGKSPIMIATDVASRGLDVKDVKYVINFDFPNQIEDYVHRIGRTGRAGAKG 475
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|
gi 1985382941 602 KAISFFDSiSDSHIAQPLVKVLSDAQQEVPSWLEEIAFSAQGTGFSNPRG 651
Cdd:PTZ00110 476 ASYTFLTP-DKYRLARDLVKVLREAKQPVPPELEKLSNERSNGTERRRWG 524
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
231-472 |
1.10e-111 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 337.01 E-value: 1.10e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 231 FDKYDTILVEVSGLDPPPAILTFEEANLCQTLNKNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPIL 310
Cdd:cd18051 1 FDKYEDIPVEATGENCPPHIETFSDLDLGEIIRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 311 AHMMKDG-------VTASHFREQQEPECIIVAPTRELINQIFLEARKFSYGTCIRPVVIYGGTQTGHSIRQIMQGCNILC 383
Cdd:cd18051 81 SQIYEQGpgeslpsESGYYGRRKQYPLALVLAPTRELASQIYDEARKFAYRSRVRPCVVYGGADIGQQMRDLERGCHLLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 384 ATPGRLMDIIGKEKIGLRKVRYLVLDEADRMLDMGFGPEMKKLISCPGMPSKDRRQTLMFSATFPEEIQRLSGEFLKpEY 463
Cdd:cd18051 161 ATPGRLVDMLERGKIGLDYCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPTGERQTLMFSATFPKEIQMLARDFLD-NY 239
|
....*....
gi 1985382941 464 LFVAVGQVG 472
Cdd:cd18051 240 IFLAVGRVG 248
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
253-607 |
1.67e-100 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 315.59 E-value: 1.67e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 253 FEEANLCQTLNKNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHmmkdgVTASHFREQqepeCI 332
Cdd:PRK11776 6 FSTLPLPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQK-----LDVKRFRVQ----AL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 333 IVAPTRELINQIFLEARKFSYGT-CIRPVVIYGGTQTGHSIRQIMQGCNILCATPGRLMDIIGKEKIGLRKVRYLVLDEA 411
Cdd:PRK11776 77 VLCPTRELADQVAKEIRRLARFIpNIKVLTLCGGVPMGPQIDSLEHGAHIIVGTPGRILDHLRKGTLDLDALNTLVLDEA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 412 DRMLDMGFGPEMKKLIS-CPGmpskdRRQTLMFSATFPEEIQRLSGEFLKpEYLFVAVGQVGGAcSDVQQTVLQVSQYSK 490
Cdd:PRK11776 157 DRMLDMGFQDAIDAIIRqAPA-----RRQTLLFSATYPEGIAAISQRFQR-DPVEVKVESTHDL-PAIEQRFYEVSPDER 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 491 REKLVEILQSIRDERTMVFVETKKKADFIATFLCQEKIPTTSIHGDREQREREEALWDFRSGKCPVLVATSVAARGLDIE 570
Cdd:PRK11776 230 LPALQRLLLHHQPESCVVFCNTKKECQEVADALNAQGFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDVAARGLDIK 309
|
330 340 350
....*....|....*....|....*....|....*..
gi 1985382941 571 KVQHVINFDLPSTIDEYVHRIGRTGRCGNIGKAISFF 607
Cdd:PRK11776 310 ALEAVINYELARDPEVHVHRIGRTGRAGSKGLALSLV 346
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
252-606 |
4.61e-89 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 284.91 E-value: 4.61e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 252 TFEEANLCQTLNKNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMKdgvtashFREQQE--P 329
Cdd:PRK11192 2 TFSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLLD-------FPRRKSgpP 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 330 ECIIVAPTRELINQIFLEARKFSYGTCIRPVVIYGGTQTGHSIRQIMQGCNILCATPGRLMDIIGKEKIGLRKVRYLVLD 409
Cdd:PRK11192 75 RILILTPTRELAMQVADQARELAKHTHLDIATITGGVAYMNHAEVFSENQDIVVATPGRLLQYIKEENFDCRAVETLILD 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 410 EADRMLDMGFGPEMKKL-ISCPGmpskdRRQTLMFSATFP-EEIQRLSGEFLK-PEYLfvavgqvggacsdvqqtvlqVS 486
Cdd:PRK11192 155 EADRMLDMGFAQDIETIaAETRW-----RKQTLLFSATLEgDAVQDFAERLLNdPVEV--------------------EA 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 487 QYSKREK-------------------LVEILQSIRDERTMVFVETKKKADFIATFLCQEKIPTTSIHGDREQREREEALW 547
Cdd:PRK11192 210 EPSRRERkkihqwyyraddlehktalLCHLLKQPEVTRSIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIK 289
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1985382941 548 DFRSGKCPVLVATSVAARGLDIEKVQHVINFDLPSTIDEYVHRIGRTGRCGNIGKAISF 606
Cdd:PRK11192 290 RLTDGRVNVLVATDVAARGIDIDDVSHVINFDMPRSADTYLHRIGRTGRAGRKGTAISL 348
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
236-631 |
1.30e-87 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 283.99 E-value: 1.30e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 236 TILVEVSGLDPPPAILTFEEANLCQTLNKNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMK 315
Cdd:PLN00206 106 KLEIHVKGEAVPPPILSFSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIISRCCT 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 316 dgVTASHFREQQEPECIIVAPTRELINQIFLEARKFSYGTCIRPVVIYGGTQTGHSIRQIMQGCNILCATPGRLMDIIGK 395
Cdd:PLN00206 186 --IRSGHPSEQRNPLAMVLTPTRELCVQVEDQAKVLGKGLPFKTALVVGGDAMPQQLYRIQQGVELIVGTPGRLIDLLSK 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 396 EKIGLRKVRYLVLDEADRMLDMGFGPEMKKLISCPGMPskdrrQTLMFSATFPEEIQRLSGEFLKpEYLFVAVGQVGGAC 475
Cdd:PLN00206 264 HDIELDNVSVLVLDEVDCMLERGFRDQVMQIFQALSQP-----QVLLFSATVSPEVEKFASSLAK-DIILISIGNPNRPN 337
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 476 SDVQQTVLQVSQYSKREKLVEILQSIRDER--TMVFVETKKKADFIAtflcqEKIPTT------SIHGDREQREREEALW 547
Cdd:PLN00206 338 KAVKQLAIWVETKQKKQKLFDILKSKQHFKppAVVFVSSRLGADLLA-----NAITVVtglkalSIHGEKSMKERREVMK 412
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 548 DFRSGKCPVLVATSVAARGLDIEKVQHVINFDLPSTIDEYVHRIGRTGRCGNIGKAISFFDSiSDSHIAQPLVKVLSDAQ 627
Cdd:PLN00206 413 SFLVGEVPVIVATGVLGRGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAIVFVNE-EDRNLFPELVALLKSSG 491
|
....
gi 1985382941 628 QEVP 631
Cdd:PLN00206 492 AAIP 495
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
251-605 |
2.70e-86 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 278.62 E-value: 2.70e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 251 LTFEEANLCQTLNKNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMKDgvtASHFREQQEPE 330
Cdd:PRK10590 1 MSFDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITR---QPHAKGRRPVR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 331 CIIVAPTRELINQIFLEARKFSYGTCIRPVVIYGGTQTGHSIRQIMQGCNILCATPGRLMDIIGKEKIGLRKVRYLVLDE 410
Cdd:PRK10590 78 ALILTPTRELAAQIGENVRDYSKYLNIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLDLEHQNAVKLDQVEILVLDE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 411 ADRMLDMGFGPEMKKLIScpGMPSKdrRQTLMFSATFPEEIQRLSGEFLK-PEYlfVAVGQVGGACSDVQQTVLQVSQYS 489
Cdd:PRK10590 158 ADRMLDMGFIHDIRRVLA--KLPAK--RQNLLFSATFSDDIKALAEKLLHnPLE--IEVARRNTASEQVTQHVHFVDKKR 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 490 KREKLVEILQSIRDERTMVFVETKKKADFIATFLCQEKIPTTSIHGDREQREREEALWDFRSGKCPVLVATSVAARGLDI 569
Cdd:PRK10590 232 KRELLSQMIGKGNWQQVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDI 311
|
330 340 350
....*....|....*....|....*....|....*.
gi 1985382941 570 EKVQHVINFDLPSTIDEYVHRIGRTGRCGNIGKAIS 605
Cdd:PRK10590 312 EELPHVVNYELPNVPEDYVHRIGRTGRAAATGEALS 347
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
262-460 |
4.09e-83 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 260.84 E-value: 4.09e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 262 LNKNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMKDGVtashfREQQEPECIIVAPTRELI 341
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPEPK-----KKGRGPQALVLAPTRELA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 342 NQIFLEARKFSYGTCIRPVVIYGGTQTGHSIRQIMQGCNILCATPGRLMDIIGKEKIGLRKVRYLVLDEADRMLDMGFGP 421
Cdd:cd00268 76 MQIAEVARKLGKGTGLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIERGKLDLSNVKYLVLDEADRMLDMGFEE 155
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1985382941 422 EMKKLIS-CPgmpskDRRQTLMFSATFPEEIQRLSGEFLK 460
Cdd:cd00268 156 DVEKILSaLP-----KDRQTLLFSATLPEEVKELAKKFLK 190
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
244-606 |
3.75e-79 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 260.23 E-value: 3.75e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 244 LDPPPAILTFEEANLCQTLNKNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMKDGVTASHF 323
Cdd:PRK01297 80 VEPQEGKTRFHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQLLQTPPPKERY 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 324 ReqQEPECIIVAPTRELINQIFLEARKFSYGTCIRPVVIYGGTQTGHSIRQI-MQGCNILCATPGRLMDIIGKEKIGLRK 402
Cdd:PRK01297 160 M--GEPRALIIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLeARFCDILVATPGRLLDFNQRGEVHLDM 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 403 VRYLVLDEADRMLDMGFGPEMKKLIScpGMPSKDRRQTLMFSATFPEEIQRLSGEFL-KPEYLFVAVGQVggACSDVQQT 481
Cdd:PRK01297 238 VEVMVLDEADRMLDMGFIPQVRQIIR--QTPRKEERQTLLFSATFTDDVMNLAKQWTtDPAIVEIEPENV--ASDTVEQH 313
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 482 VLQVSQYSKREKLVEILQSIRDERTMVFVETKKKADFIATFLCQEKIPTTSIHGDREQREREEALWDFRSGKCPVLVATS 561
Cdd:PRK01297 314 VYAVAGSDKYKLLYNLVTQNPWERVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATD 393
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1985382941 562 VAARGLDIEKVQHVINFDLPSTIDEYVHRIGRTGRCGNIGKAISF 606
Cdd:PRK01297 394 VAGRGIHIDGISHVINFTLPEDPDDYVHRIGRTGRAGASGVSISF 438
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
245-606 |
2.58e-75 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 252.95 E-value: 2.58e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 245 DPPPAILTFEEANLCQTLNKNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMKDGVTAShfR 324
Cdd:PRK04537 3 DKPLTDLTFSSFDLHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLLSRPALAD--R 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 325 EQQEPECIIVAPTRELINQIFLEARKFSYGTCIRPVVIYGGTQTGHSIRQIMQGCNILCATPGRLMDIIGKEKI-GLRKV 403
Cdd:PRK04537 81 KPEDPRALILAPTRELAIQIHKDAVKFGADLGLRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDYVKQHKVvSLHAC 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 404 RYLVLDEADRMLDMGFGPEMKKLIScpGMPSKDRRQTLMFSATFPEEIQRLSGEFL-KPEYLFVAVGQVGGAcsDVQQTV 482
Cdd:PRK04537 161 EICVLDEADRMFDLGFIKDIRFLLR--RMPERGTRQTLLFSATLSHRVLELAYEHMnEPEKLVVETETITAA--RVRQRI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 483 LQVSQYSKREKLVEILQSIRDERTMVFVETKKKADFIATFLCQEKIPTTSIHGDREQREREEALWDFRSGKCPVLVATSV 562
Cdd:PRK04537 237 YFPADEEKQTLLLGLLSRSEGARTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDV 316
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1985382941 563 AARGLDIEKVQHVINFDLPSTIDEYVHRIGRTGRCGNIGKAISF 606
Cdd:PRK04537 317 AARGLHIDGVKYVYNYDLPFDAEDYVHRIGRTARLGEEGDAISF 360
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
266-606 |
1.32e-70 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 236.02 E-value: 1.32e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 266 IAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMKDgvTASHFREQQEPECIIVAPTRELINQIF 345
Cdd:PRK04837 23 LEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTATFHYLLSH--PAPEDRKVNQPRALIMAPTRELAVQIH 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 346 LEARKFSYGTCIRPVVIYGGTQTGHSIRQIMQGCNILCATPGRLMDIIGKEKIGLRKVRYLVLDEADRMLDMGFGPEMKK 425
Cdd:PRK04837 101 ADAEPLAQATGLKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQNHINLGAIQVVVLDEADRMFDLGFIKDIRW 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 426 LIScpGMPSKDRRQTLMFSATFPEEIQRLSGEFL-KPEYLFVAVGQVGGacSDVQQTVLQVSQYSKREKLVEILQSIRDE 504
Cdd:PRK04837 181 LFR--RMPPANQRLNMLFSATLSYRVRELAFEHMnNPEYVEVEPEQKTG--HRIKEELFYPSNEEKMRLLQTLIEEEWPD 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 505 RTMVFVETKKKADFIATFLCQEKIPTTSIHGDREQREREEALWDFRSGKCPVLVATSVAARGLDIEKVQHVINFDLPSTI 584
Cdd:PRK04837 257 RAIIFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKKRLRILEEFTRGDLDILVATDVAARGLHIPAVTHVFNYDLPDDC 336
|
330 340
....*....|....*....|..
gi 1985382941 585 DEYVHRIGRTGRCGNIGKAISF 606
Cdd:PRK04837 337 EDYVHRIGRTGRAGASGHSISL 358
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
252-609 |
7.58e-66 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 228.96 E-value: 7.58e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 252 TFEEANLCQTLNKNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILaHMMKDGVTAshfreqqePEC 331
Cdd:PRK11634 7 TFADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLL-HNLDPELKA--------PQI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 332 IIVAPTRELINQIFLEARKFS-YGTCIRPVVIYGGTQTGHSIRQIMQGCNILCATPGRLMDIIGKEKIGLRKVRYLVLDE 410
Cdd:PRK11634 78 LVLAPTRELAVQVAEAMTDFSkHMRGVNVVALYGGQRYDVQLRALRQGPQIVVGTPGRLLDHLKRGTLDLSKLSGLVLDE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 411 ADRMLDMGFGPEMKKLIScpGMPskDRRQTLMFSATFPEEIQRLSGEFLK-PEYlfVAVGQVGGACSDVQQTVLQVSQYS 489
Cdd:PRK11634 158 ADEMLRMGFIEDVETIMA--QIP--EGHQTALFSATMPEAIRRITRRFMKePQE--VRIQSSVTTRPDISQSYWTVWGMR 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 490 KREKLVEILQSIRDERTMVFVETKKKADFIATFLCQEKIPTTSIHGDREQREREEALWDFRSGKCPVLVATSVAARGLDI 569
Cdd:PRK11634 232 KNEALVRFLEAEDFDAAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAARGLDV 311
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1985382941 570 EKVQHVINFDLPSTIDEYVHRIGRTGRCGNIGKAISFFDS 609
Cdd:PRK11634 312 ERISLVVNYDIPMDSESYVHRIGRTGRAGRAGRALLFVEN 351
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
264-466 |
1.34e-65 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 214.93 E-value: 1.34e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 264 KNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMKDgvtaSHFREQQEPECIIVAPTRELINQ 343
Cdd:cd17966 3 DELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIVHINAQ----PPLERGDGPIVLVLAPTRELAQQ 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 344 IFLEARKFSYGTCIRPVVIYGGTQTGHSIRQIMQGCNILCATPGRLMDIIGKEKIGLRKVRYLVLDEADRMLDMGFGPEM 423
Cdd:cd17966 79 IQQEANKFGGSSRLRNTCVYGGAPKGPQIRDLRRGVEICIATPGRLIDFLDQGKTNLRRVTYLVLDEADRMLDMGFEPQI 158
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1985382941 424 KKLIScpgmPSKDRRQTLMFSATFPEEIQRLSGEFLKpEYLFV 466
Cdd:cd17966 159 RKIVD----QIRPDRQTLMWSATWPKEVRRLAEDFLK-DYIQV 196
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
275-454 |
6.86e-61 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 200.93 E-value: 6.86e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 275 TPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMKdgvtashfrEQQEPECIIVAPTRELINQIFLEARKFSYG 354
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDK---------LDNGPQALVLAPTRELAEQIYEELKKLGKG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 355 TCIRPVVIYGGTQTGHSIRQImQGCNILCATPGRLMDIIGKEKiGLRKVRYLVLDEADRMLDMGFGPEMKKLISCpgMPS 434
Cdd:pfam00270 72 LGLKVASLLGGDSRKEQLEKL-KGPDILVGTPGRLLDLLQERK-LLKNLKLLVLDEAHRLLDMGFGPDLEEILRR--LPK 147
|
170 180
....*....|....*....|
gi 1985382941 435 KdrRQTLMFSATFPEEIQRL 454
Cdd:pfam00270 148 K--RQILLLSATLPRNLEDL 165
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
262-459 |
2.05e-59 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 198.41 E-value: 2.05e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 262 LNKNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMKDgvtaSHFREQQEPECIIVAPTRELI 341
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVHIMDQ----RELEKGEGPIAVIVAPTRELA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 342 NQIFLEARKFSYGTCIRPVVIYGGTQTGHSIRQIMQGCNILCATPGRLMDIIGKEKIGLRKVRYLVLDEADRMLDMGFGP 421
Cdd:cd17952 77 QQIYLEAKKFGKAYNLRVVAVYGGGSKWEQAKALQEGAEIVVATPGRLIDMVKKKATNLQRVTYLVLDEADRMFDMGFEY 156
|
170 180 190
....*....|....*....|....*....|....*...
gi 1985382941 422 EMKKLIScpgmPSKDRRQTLMFSATFPEEIQRLSGEFL 459
Cdd:cd17952 157 QVRSIVG----HVRPDRQTLLFSATFKKKIEQLARDIL 190
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
264-466 |
3.02e-59 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 198.58 E-value: 3.02e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 264 KNIAKAGYLKLTPVQKYSIPIILA-GRDLMACAQTGSGKTAAFLLPILAHMMKDgvtasHFREQQEP-ECIIVAPTRELI 341
Cdd:cd17964 7 KALTRMGFETMTPVQQKTLKPILStGDDVLARAKTGTGKTLAFLLPAIQSLLNT-----KPAGRRSGvSALIISPTRELA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 342 NQIFLEARKF-SYGTCIRPVVIYGGTQTGHSIRQIM-QGCNILCATPGRLMDIIGKEKIG--LRKVRYLVLDEADRMLDM 417
Cdd:cd17964 82 LQIAAEAKKLlQGLRKLRVQSAVGGTSRRAELNRLRrGRPDILVATPGRLIDHLENPGVAkaFTDLDYLVLDEADRLLDM 161
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1985382941 418 GFGPEMKKLISCPGMPSKDRRQTLMFSATFPEEIQRLSGEFLKPEYLFV 466
Cdd:cd17964 162 GFRPDLEQILRHLPEKNADPRQTLLFSATVPDEVQQIARLTLKKDYKFI 210
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
478-607 |
4.07e-58 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 192.34 E-value: 4.07e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 478 VQQTVLQVSQYSKREKL-VEILQSIRDERTMVFVETKKKADFIATFLCQEKIPTTSIHGDREQREREEALWDFRSGKCPV 556
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLlLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1985382941 557 LVATSVAARGLDIEKVQHVINFDLPSTIDEYVHRIGRTGRCGNIGKAISFF 607
Cdd:cd18787 81 LVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
241-460 |
1.05e-57 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 194.52 E-value: 1.05e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 241 VSGLDPPPAILTFEEANLCQTLNKNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMkdgvtA 320
Cdd:cd17953 2 VRGKDCPKPIQKWSQCGLSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRHIK-----D 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 321 SHFREQQE-PECIIVAPTRELINQIFLEARKFSYGTCIRPVVIYGGTQTGHSIRQIMQGCNILCATPGRLMDII---GKE 396
Cdd:cd17953 77 QRPVKPGEgPIGLIMAPTRELALQIYVECKKFSKALGLRVVCVYGGSGISEQIAELKRGAEIVVCTPGRMIDILtanNGR 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1985382941 397 KIGLRKVRYLVLDEADRMLDMGFGPEMKKLIscpgMPSKDRRQTLMFSATFPEEIQRLSGEFLK 460
Cdd:cd17953 157 VTNLRRVTYVVLDEADRMFDMGFEPQIMKIV----NNIRPDRQTVLFSATFPRKVEALARKVLH 216
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
262-469 |
6.19e-57 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 191.65 E-value: 6.19e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 262 LNKNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMKDgvtashfREQQEPECIIVAPTRELI 341
Cdd:cd17957 1 LLNNLEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKLGKP-------RKKKGLRALILAPTRELA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 342 NQIFLEARKFSYGTCIRPVVIYGGTQTG-HSIRQIMQGCNILCATPGRLMDIIGKEKIGLRKVRYLVLDEADRMLDMGFG 420
Cdd:cd17957 74 SQIYRELLKLSKGTGLRIVLLSKSLEAKaKDGPKSITKYDILVSTPLRLVFLLKQGPIDLSSVEYLVLDEADKLFEPGFR 153
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1985382941 421 PEMKKLI-SCPGmPSKdrrQTLMFSATFPEEIQRLSGEFLKPeYLFVAVG 469
Cdd:cd17957 154 EQTDEILaACTN-PNL---QRSLFSATIPSEVEELARSVMKD-PIRIIVG 198
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
239-469 |
2.26e-56 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 191.76 E-value: 2.26e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 239 VEVSGLDPPPAILTFEEANLCQTLNKNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHmmkdgV 318
Cdd:cd18049 12 ITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVH-----I 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 319 TASHFREQQE-PECIIVAPTRELINQIFLEARKFSYGTCIRPVVIYGGTQTGHSIRQIMQGCNILCATPGRLMDIIGKEK 397
Cdd:cd18049 87 NHQPFLERGDgPICLVLAPTRELAQQVQQVAAEYGRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGK 166
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1985382941 398 IGLRKVRYLVLDEADRMLDMGFGPEMKKLIScpgmPSKDRRQTLMFSATFPEEIQRLSGEFLKpEYLFVAVG 469
Cdd:cd18049 167 TNLRRCTYLVLDEADRMLDMGFEPQIRKIVD----QIRPDRQTLMWSATWPKEVRQLAEDFLK-DYIHINIG 233
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
266-460 |
3.73e-56 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 190.61 E-value: 3.73e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 266 IAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMK----DGVTashfrEQQEPECIIVAPTRELI 341
Cdd:cd17945 5 IRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISRlpplDEET-----KDDGPYALILAPTRELA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 342 NQIFLEARKFSYGTCIRPVVIYGGtqtgHSIR----QIMQGCNILCATPGRLMDIIGKEKIGLRKVRYLVLDEADRMLDM 417
Cdd:cd17945 80 QQIEEETQKFAKPLGIRVVSIVGG----HSIEeqafSLRNGCEILIATPGRLLDCLERRLLVLNQCTYVVLDEADRMIDM 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1985382941 418 GFGPEMKKLIScpGMPS------------------KDRRQTLMFSATFPEEIQRLSGEFLK 460
Cdd:cd17945 156 GFEPQVTKILD--AMPVsnkkpdteeaeklaasgkHRYRQTMMFTATMPPAVEKIAKGYLR 214
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
252-606 |
6.29e-55 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 193.12 E-value: 6.29e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 252 TFEEANLCQTLNKNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMKDGVTAshfreqqepEC 331
Cdd:PTZ00424 29 SFDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLIDYDLNAC---------QA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 332 IIVAPTRELINQIFLEARKFSYGTCIRPVVIYGGTQTGHSIRQIMQGCNILCATPGRLMDIIGKEKIGLRKVRYLVLDEA 411
Cdd:PTZ00424 100 LILAPTRELAQQIQKVVLALGDYLKVRCHACVGGTVVRDDINKLKAGVHMVVGTPGRVYDMIDKRHLRVDDLKLFILDEA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 412 DRMLDMGFGPEMKKLIScpGMPSKdrRQTLMFSATFPEEIQRLSGEFLK-PEYLFVAVGQVggACSDVQQTVLQVSQYS- 489
Cdd:PTZ00424 180 DEMLSRGFKGQIYDVFK--KLPPD--VQVALFSATMPNEILELTTKFMRdPKRILVKKDEL--TLEGIRQFYVAVEKEEw 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 490 KREKLVEILQSIRDERTMVFVETKKKADFIATFLCQEKIPTTSIHGDREQREREEALWDFRSGKCPVLVATSVAARGLDI 569
Cdd:PTZ00424 254 KFDTLCDLYETLTITQAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDV 333
|
330 340 350
....*....|....*....|....*....|....*..
gi 1985382941 570 EKVQHVINFDLPSTIDEYVHRIGRTGRCGNIGKAISF 606
Cdd:PTZ00424 334 QQVSLVINYDLPASPENYIHRIGRSGRFGRKGVAINF 370
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
264-460 |
1.54e-51 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 177.27 E-value: 1.54e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 264 KNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMmkdgVTASHFREQQE-PECIIVAPTRELIN 342
Cdd:cd17958 3 KEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFIHL----DLQPIPREQRNgPGVLVLTPTRELAL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 343 QIFLEARKFSYGTcIRPVVIYGGTQTGHSIRQIMQGCNILCATPGRLMDIIGKEKIGLRKVRYLVLDEADRMLDMGFGPE 422
Cdd:cd17958 79 QIEAECSKYSYKG-LKSVCVYGGGNRNEQIEDLSKGVDIIIATPGRLNDLQMNNVINLKSITYLVLDEADRMLDMGFEPQ 157
|
170 180 190
....*....|....*....|....*....|....*...
gi 1985382941 423 MKKLIscpgMPSKDRRQTLMFSATFPEEIQRLSGEFLK 460
Cdd:cd17958 158 IRKIL----LDIRPDRQTIMTSATWPDGVRRLAQSYLK 191
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
266-466 |
1.63e-51 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 177.30 E-value: 1.63e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 266 IAKAGYLKLTPVQKYSIPIILAG-RDLMACAQTGSGKTAAFLLPILAHmmkdgvtashFREQQEPECIIVAPTRELINQI 344
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEA----------LKRGKGGRVLVLVPTRELAEQW 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 345 FLEARKFSYGTCIRPVVIYGGTQTGHSIRQIMQGC-NILCATPGRLMDIIGKEKIGLRKVRYLVLDEADRMLDMGFGPEM 423
Cdd:smart00487 71 AEELKKLGPSLGLKVVGLYGGDSKREQLRKLESGKtDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGGFGDQL 150
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1985382941 424 KKLIScpgmPSKDRRQTLMFSATFPEEIQRLSGEFLKPEYLFV 466
Cdd:smart00487 151 EKLLK----LLPKNVQLLLLSATPPEEIENLLELFLNDPVFID 189
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
253-466 |
3.93e-51 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 176.26 E-value: 3.93e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 253 FEEANLCQTLNKNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMKDGVtaSHFreqqepeCI 332
Cdd:cd17955 1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRLSEDPY--GIF-------AL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 333 IVAPTRELINQIFLEARKFSYGTCIRPVVIYGGTQtghSIRQ---IMQGCNILCATPGRLMDII---GKEKIGLRKVRYL 406
Cdd:cd17955 72 VLTPTRELAYQIAEQFRALGAPLGLRCCVIVGGMD---MVKQaleLSKRPHIVVATPGRLADHLrssDDTTKVLSRVKFL 148
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 407 VLDEADRMLDMGFGPEMKKLISCpgMPSKdrRQTLMFSATFPEEIQRLSGEFLKPEYLFV 466
Cdd:cd17955 149 VLDEADRLLTGSFEDDLATILSA--LPPK--RQTLLFSATLTDALKALKELFGNKPFFWE 204
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
239-469 |
8.91e-51 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 177.90 E-value: 8.91e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 239 VEVSGLDPPPAILTFEEANLCQTLNKNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMKDgv 318
Cdd:cd18050 50 ITIRGVGCPKPVFAFHQANFPQYVMDVLLDQNFKEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQ-- 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 319 taSHFREQQEPECIIVAPTRELINQIflEARKFSYGTC--IRPVVIYGGTQTGHSIRQIMQGCNILCATPGRLMDIIGKE 396
Cdd:cd18050 128 --PYLERGDGPICLVLAPTRELAQQV--QQVADDYGKSsrLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAG 203
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1985382941 397 KIGLRKVRYLVLDEADRMLDMGFGPEMKKLIScpgmPSKDRRQTLMFSATFPEEIQRLSGEFLKpEYLFVAVG 469
Cdd:cd18050 204 KTNLRRCTYLVLDEADRMLDMGFEPQIRKIVD----QIRPDRQTLMWSATWPKEVRQLAEDFLR-DYVQINIG 271
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
268-464 |
2.34e-49 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 172.00 E-value: 2.34e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 268 KAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMKDgvtASHFREQQEPECIIVAPTRELINQIFLE 347
Cdd:cd17949 8 KMGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLSL---EPRVDRSDGTLALVLVPTRELALQIYEV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 348 ARKF-SYGTCIRPVVIYGGTQTGHSIRQIMQGCNILCATPGRLMDIIGKEK-IGLRKVRYLVLDEADRMLDMGFGPEMKK 425
Cdd:cd17949 85 LEKLlKPFHWIVPGYLIGGEKRKSEKARLRKGVNILIATPGRLLDHLKNTQsFDVSNLRWLVLDEADRLLDMGFEKDITK 164
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1985382941 426 LIS--------CPGMPSKD-RRQTLMFSATFPEEIQRLSGEFLK-PEYL 464
Cdd:cd17949 165 ILEllddkrskAGGEKSKPsRRQTVLVSATLTDGVKRLAGLSLKdPVYI 213
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
252-449 |
1.61e-48 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 169.41 E-value: 1.61e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 252 TFEEANLCQTLNKNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPIL----AHMMKDGVTAshfreqq 327
Cdd:cd17959 2 GFQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIeklkAHSPTVGARA------- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 328 epecIIVAPTRELINQIFLEARKFSYGTCIRPVVIYGGTQTGHSIRQIMQGCNILCATPGRLMDIIGKEKIGLRKVRYLV 407
Cdd:cd17959 75 ----LILSPTRELALQTLKVTKELGKFTDLRTALLVGGDSLEEQFEALASNPDIIIATPGRLLHLLVEMNLKLSSVEYVV 150
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1985382941 408 LDEADRMLDMGFGPEMKKLIScpGMPSKdrRQTLMFSATFPE 449
Cdd:cd17959 151 FDEADRLFEMGFAEQLHEILS--RLPEN--RQTLLFSATLPK 188
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
264-460 |
2.71e-48 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 168.20 E-value: 2.71e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 264 KNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMkdgvtashFREQQEPEC--IIVAPTRELI 341
Cdd:cd17947 3 RALSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERLL--------YRPKKKAATrvLVLVPTRELA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 342 NQIFLEARKFSYGTCIRPVVIYGGTqtghSIRQ----IMQGCNILCATPGRLMDIIGKEK-IGLRKVRYLVLDEADRMLD 416
Cdd:cd17947 75 MQCFSVLQQLAQFTDITFALAVGGL----SLKAqeaaLRARPDIVIATPGRLIDHLRNSPsFDLDSIEILVLDEADRMLE 150
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1985382941 417 MGFGPEMKKLI-SCPGmpskdRRQTLMFSATFPEEIQRLSGEFLK 460
Cdd:cd17947 151 EGFADELKEILrLCPR-----TRQTMLFSATMTDEVKDLAKLSLN 190
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
252-454 |
3.64e-48 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 168.26 E-value: 3.64e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 252 TFEEANLCQTLNKNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMKDgvtashfreQQEPEC 331
Cdd:cd17954 1 TFKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQALLEN---------PQRFFA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 332 IIVAPTRELINQIFLEARKFSYGTCIRPVVIYGGTQTGHSIRQIMQGCNILCATPGRLMDIIGKEK-IGLRKVRYLVLDE 410
Cdd:cd17954 72 LVLAPTRELAQQISEQFEALGSSIGLKSAVLVGGMDMMAQAIALAKKPHVIVATPGRLVDHLENTKgFSLKSLKFLVMDE 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1985382941 411 ADRMLDMGFGPEMKKLISCpgMPSkdRRQTLMFSATFPEEIQRL 454
Cdd:cd17954 152 ADRLLNMDFEPEIDKILKV--IPR--ERTTYLFSATMTTKVAKL 191
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
266-454 |
7.43e-47 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 164.67 E-value: 7.43e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 266 IAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMKdgvtashfREQQEPE----CIIVAPTRELI 341
Cdd:cd17960 5 VAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEILLK--------RKANLKKgqvgALIISPTRELA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 342 NQIFLEARKF--SYGTCIRPVVIYGGTQTGHSIRQIM-QGCNILCATPGRLMDIIGKEKiGLRKVR---YLVLDEADRML 415
Cdd:cd17960 77 TQIYEVLQSFleHHLPKLKCQLLIGGTNVEEDVKKFKrNGPNILVGTPGRLEELLSRKA-DKVKVKsleVLVLDEADRLL 155
|
170 180 190
....*....|....*....|....*....|....*....
gi 1985382941 416 DMGFGPEMKKLISCpgMPsKDRRqTLMFSATFPEEIQRL 454
Cdd:cd17960 156 DLGFEADLNRILSK--LP-KQRR-TGLFSATQTDAVEEL 190
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
264-466 |
2.72e-46 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 162.84 E-value: 2.72e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 264 KNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMmkdgvtashFREQQEPE----CIIVAPTRE 339
Cdd:cd17941 3 KGLKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKL---------YRERWTPEdglgALIISPTRE 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 340 LINQIFLEARKFSYGTCIRPVVIYGGTQTGHSiRQIMQGCNILCATPGRL---MDiigkEKIGL--RKVRYLVLDEADRM 414
Cdd:cd17941 74 LAMQIFEVLRKVGKYHSFSAGLIIGGKDVKEE-KERINRMNILVCTPGRLlqhMD----ETPGFdtSNLQMLVLDEADRI 148
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1985382941 415 LDMGFGPEMKKLIScpGMPSKdrRQTLMFSATFPEEIQRLSGEFLK-PEYLFV 466
Cdd:cd17941 149 LDMGFKETLDAIVE--NLPKS--RQTLLFSATQTKSVKDLARLSLKnPEYISV 197
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
264-466 |
6.41e-45 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 159.06 E-value: 6.41e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 264 KNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILahmmkDGVTASHFREQQEPECIIVAPTRELINQ 343
Cdd:cd17942 3 KAIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAI-----ELLYKLKFKPRNGTGVIIISPTRELALQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 344 IFLEARKF------SYGTCIrpvviyGGTQTGHSIRQIMQGCNILCATPGRLMDIIGKEKIGLRK-VRYLVLDEADRMLD 416
Cdd:cd17942 78 IYGVAKELlkyhsqTFGIVI------GGANRKAEAEKLGKGVNILVATPGRLLDHLQNTKGFLYKnLQCLIIDEADRILE 151
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1985382941 417 MGFGPEMKKLISCpgMPSkdRRQTLMFSATFPEEIQRLSGEFLKPEYLFV 466
Cdd:cd17942 152 IGFEEEMRQIIKL--LPK--RRQTMLFSATQTRKVEDLARISLKKKPLYV 197
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
253-463 |
1.03e-44 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 158.62 E-value: 1.03e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 253 FEEANLCQTLNKNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPIL--AHMMKDGVTAshfreqqepe 330
Cdd:cd17940 1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILekIDPKKDVIQA---------- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 331 cIIVAPTRELINQIFLEARKFSYGTCIRPVVIYGGTQTGHSIRQIMQGCNILCATPGRLMDIIGKEKIGLRKVRYLVLDE 410
Cdd:cd17940 71 -LILVPTRELALQTSQVCKELGKHMGVKVMVTTGGTSLRDDIMRLYQTVHVLVGTPGRILDLAKKGVADLSHCKTLVLDE 149
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1985382941 411 ADRMLDMGFGPEMKKLIS-CPgmpskDRRQTLMFSATFPEEIQRLSGEFLKPEY 463
Cdd:cd17940 150 ADKLLSQDFQPIIEKILNfLP-----KERQILLFSATFPLTVKNFMDRHMHNPY 198
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
253-446 |
4.95e-43 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 154.02 E-value: 4.95e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 253 FEEANLCQTLNKNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILahmmkdgvtashfreqQEPECI 332
Cdd:cd17938 1 FEELGVMPELIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVL----------------QIVVAL 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 333 IVAPTRELINQIFLEARKFSY---GTCIRPVVIYGGTQTGHSIRQIMQGCNILCATPGRLMDIIGKEKIGLRKVRYLVLD 409
Cdd:cd17938 65 ILEPSRELAEQTYNCIENFKKyldNPKLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTGKLDLSSVRFFVLD 144
|
170 180 190
....*....|....*....|....*....|....*....
gi 1985382941 410 EADRMLDMGFGPEMKKLIS-CPGMPSKDRR-QTLMFSAT 446
Cdd:cd17938 145 EADRLLSQGNLETINRIYNrIPKITSDGKRlQVIVCSAT 183
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
264-452 |
1.64e-42 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 152.88 E-value: 1.64e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 264 KNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMKDGVTAShFREQQEPECIIVAPTRELINQ 343
Cdd:cd17951 3 KGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLIMFALEQEKKLP-FIKGEGPYGLIVCPSRELARQ 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 344 IF---------LEARKFSYgtcIRPVVIYGGTQTGHSIRQIMQGCNILCATPGRLMDIIGKEKIGLRKVRYLVLDEADRM 414
Cdd:cd17951 82 THevieyyckaLQEGGYPQ---LRCLLCIGGMSVKEQLEVIRKGVHIVVATPGRLMDMLNKKKINLDICRYLCLDEADRM 158
|
170 180 190
....*....|....*....|....*....|....*...
gi 1985382941 415 LDMGFGPEMKKLISCpgmpSKDRRQTLMFSATFPEEIQ 452
Cdd:cd17951 159 IDMGFEEDIRTIFSY----FKGQRQTLLFSATMPKKIQ 192
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
262-460 |
1.21e-41 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 150.01 E-value: 1.21e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 262 LNKNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMKdgvtashfrEQQEPECIIVAPTRELI 341
Cdd:cd17962 1 LSSNLKKAGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRCLT---------EHRNPSALILTPTRELA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 342 NQIFLEARKFSYGTC-IRPVVIYGGTQTGHSIRQIMQGCNILCATPGRLMDIIGKEKIGLRKVRYLVLDEADRMLDMGFG 420
Cdd:cd17962 72 VQIEDQAKELMKGLPpMKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQSSVELDNIKIVVVDEADTMLKMGFQ 151
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1985382941 421 PE-MKKLISCPGMPskdrrQTLMFSATFPEEIQRLSGEFLK 460
Cdd:cd17962 152 QQvLDILENISHDH-----QTILVSATIPRGIEQLAGQLLQ 187
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
264-447 |
4.63e-41 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 149.70 E-value: 4.63e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 264 KNIAKAGYLKLTPVQKYSIP-IILAGRDLMACAQTGSGKTAAFLLPILAHMMKDGVTASHFREQQEPECIIVAPTRELIN 342
Cdd:cd17946 3 RALADLGFSEPTPIQALALPaAIRDGKDVIGAAETGSGKTLAFGIPILERLLSQKSSNGVGGKQKPLRALILTPTRELAV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 343 QI---FLEARKFsygTCIRPVVIYGGTQTGHSIRQIMQGCNILCATPGRLMDIIGK--EKIG-LRKVRYLVLDEADRMLD 416
Cdd:cd17946 83 QVkdhLKAIAKY---TNIKIASIVGGLAVQKQERLLKKRPEIVVATPGRLWELIQEgnEHLAnLKSLRFLVLDEADRMLE 159
|
170 180 190
....*....|....*....|....*....|....
gi 1985382941 417 MGFGPEMKKLISC---PGMPSKDRRQTLMFSATF 447
Cdd:cd17946 160 KGHFAELEKILELlnkDRAGKKRKRQTFVFSATL 193
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
489-598 |
2.78e-39 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 140.04 E-value: 2.78e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 489 SKREKLVEILQSIRDERTMVFVETKKKADfIATFLCQEKIPTTSIHGDREQREREEALWDFRSGKCPVLVATSVAARGLD 568
Cdd:pfam00271 1 EKLEALLELLKKERGGKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLD 79
|
90 100 110
....*....|....*....|....*....|
gi 1985382941 569 IEKVQHVINFDLPSTIDEYVHRIGRTGRCG 598
Cdd:pfam00271 80 LPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
262-460 |
3.63e-36 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 135.02 E-value: 3.63e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 262 LNKNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMKDGVTAshfREQQEPECIIVAPTRELI 341
Cdd:cd17961 5 LLKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKILKAKAES---GEEQGTRALILVPTRELA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 342 NQIFLEARKFSYGTC--IRPVVIYGGTQTGHSIRQIMQGCNILCATPGRLMDII-GKEKIGLRKVRYLVLDEADRMLDMG 418
Cdd:cd17961 82 QQVSKVLEQLTAYCRkdVRVVNLSASSSDSVQRALLAEKPDIVVSTPARLLSHLeSGSLLLLSTLKYLVIDEADLVLSYG 161
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1985382941 419 FGPEMKKLIScpGMPSkdRRQTLMFSATFPEEIQRLSGEFLK 460
Cdd:cd17961 162 YEEDLKSLLS--YLPK--NYQTFLMSATLSEDVEALKKLVLH 199
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
262-461 |
7.20e-34 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 128.08 E-value: 7.20e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 262 LNKNIAKAGYLKLTPVQKYSIPIILAG--RDLMACAQTGSGKTAAFLLPILAHMmkDgvtashfREQQEPECIIVAPTRE 339
Cdd:cd17963 5 LLKGLYAMGFNKPSKIQETALPLILSDppENLIAQSQSGTGKTAAFVLAMLSRV--D-------PTLKSPQALCLAPTRE 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 340 LINQIFLEARKFSYGT------CIRPVVIYGGTQ-TGHsirqimqgcnILCATPGRLMDIIGKEKIGLRKVRYLVLDEAD 412
Cdd:cd17963 76 LARQIGEVVEKMGKFTgvkvalAVPGNDVPRGKKiTAQ----------IVIGTPGTVLDWLKKRQLDLKKIKILVLDEAD 145
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1985382941 413 RMLDM-GFGPE---MKKLIscpgmpsKDRRQTLMFSATFPEEIQRLSGEFLKP 461
Cdd:cd17963 146 VMLDTqGHGDQsirIKRML-------PRNCQILLFSATFPDSVRKFAEKIAPN 191
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
264-463 |
9.69e-34 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 128.04 E-value: 9.69e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 264 KNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMKDgvtASHFREQQEPECIIVAPTRELINQ 343
Cdd:cd17944 3 KLLQARGVTYLFPIQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKLQED---QQPRKRGRAPKVLVLAPTRELANQ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 344 IFLE----ARKFSYgTCIrpvviYGGTQTGHSIRQIMQGCNILCATPGRLMDIIGKEKIGLRKVRYLVLDEADRMLDMGF 419
Cdd:cd17944 80 VTKDfkdiTRKLSV-ACF-----YGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNGRLDLTKLKHVVLDEVDQMLDMGF 153
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1985382941 420 GPEMKKLISCP-GMPSKDRRQTLMFSATFPEEIQRLSGEFLKPEY 463
Cdd:cd17944 154 AEQVEEILSVSyKKDSEDNPQTLLFSATCPDWVYNVAKKYMKSQY 198
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
262-454 |
4.35e-33 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 126.98 E-value: 4.35e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 262 LNKNIAKAGYLKLTPVQKYSIPIILAG---------RDLMACAQTGSGKTAAFLLPILAhMMKDGVtASHFReqqepeCI 332
Cdd:cd17956 1 LLKNLQNNGITSAFPVQAAVIPWLLPSskstppyrpGDLCVSAPTGSGKTLAYVLPIVQ-ALSKRV-VPRLR------AL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 333 IVAPTRELINQIFLEARKFSYGTCIRPVVIYGGTQTGHSIRQIMQGC--------NILCATPGRLMD-IIGKEKIGLRKV 403
Cdd:cd17956 73 IVVPTKELVQQVYKVFESLCKGTGLKVVSLSGQKSFKKEQKLLLVDTsgrylsrvDILVATPGRLVDhLNSTPGFTLKHL 152
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 404 RYLVLDEADRMLDMGFGPEMKKLISCPGMPSKDRR----------------QTLMFSATF---PEEIQRL 454
Cdd:cd17956 153 RFLVIDEADRLLNQSFQDWLETVMKALGRPTAPDLgsfgdanllersvrplQKLLFSATLtrdPEKLSSL 222
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
262-466 |
1.36e-30 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 119.37 E-value: 1.36e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 262 LNKNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILaHMMKDgvtashfrEQQEPECIIVAPTRELI 341
Cdd:cd17950 13 LLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTL-QQLEP--------VDGQVSVLVICHTRELA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 342 NQIFLEARKFS-YGTCIRPVVIYGGTQTGHSIRQIMQGC-NILCATPGRLMDIIGKEKIGLRKVRYLVLDEADRMLDmgf 419
Cdd:cd17950 84 FQISNEYERFSkYMPNVKTAVFFGGVPIKKDIEVLKNKCpHIVVGTPGRILALVREKKLKLSHVKHFVLDECDKMLE--- 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1985382941 420 GPEMKKLI-----SCPgmpsKDrRQTLMFSATFPEEIQRLSGEFLK-PEYLFV 466
Cdd:cd17950 161 QLDMRRDVqeifrATP----HD-KQVMMFSATLSKEIRPVCKKFMQdPLEIFV 208
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
265-449 |
1.57e-29 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 117.08 E-value: 1.57e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 265 NIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMKDGVTAShfREQQEPECIIVAPTRELINQI 344
Cdd:cd17948 4 ILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLLRYKLLAE--GPFNAPRGLVITPSRELAEQI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 345 FLEARKFSYGTCIRPVVIYGgtqtGHSIRQIM----QGCNILCATPGRLMDIIGKEKIGLRKVRYLVLDEADRMLDMGFG 420
Cdd:cd17948 82 GSVAQSLTEGLGLKVKVITG----GRTKRQIRnphfEEVDILVATPGALSKLLTSRIYSLEQLRHLVLDEADTLLDDSFN 157
|
170 180 190
....*....|....*....|....*....|....*...
gi 1985382941 421 PEMKKLIS-CP--GMPSKDRR------QTLMFSATFPE 449
Cdd:cd17948 158 EKLSHFLRrFPlaSRRSENTDgldpgtQLVLVSATMPS 195
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
255-459 |
3.45e-29 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 115.11 E-value: 3.45e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 255 EANLCQTLNKNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMkdgvtashfREQQEPECIIV 334
Cdd:cd17939 1 DMGLSEDLLRGIYAYGFEKPSAIQQRAIVPIIKGRDVIAQAQSGTGKTATFSIGALQRID---------TTVRETQALVL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 335 APTRELINQI---------FLEARKFsygTCIrpvviyGGTQTGHSIRQIMQGCNILCATPGRLMDIIGKEKIGLRKVRY 405
Cdd:cd17939 72 APTRELAQQIqkvvkalgdYMGVKVH---ACI------GGTSVREDRRKLQYGPHIVVGTPGRVFDMLQRRSLRTDKIKM 142
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1985382941 406 LVLDEADRMLDMGFGPEMKKLISCpgMPSKdrRQTLMFSATFPEEIQRLSGEFL 459
Cdd:cd17939 143 FVLDEADEMLSRGFKDQIYDIFQF--LPPE--TQVVLFSATMPHEVLEVTKKFM 192
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
264-449 |
3.69e-29 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 114.67 E-value: 3.69e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 264 KNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLlpILAHMMKDgvtashfREQQEPECIIVAPTRELINQ 343
Cdd:cd17943 3 EGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFV--VIALESLD-------LERRHPQVLILAPTREIAVQ 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 344 IFLEARKF-SYGTCIRPVVIYGGTQTGHSiRQIMQGCNILCATPGRLMDIIGKEKIGLRKVRYLVLDEADRMLDMGFGPE 422
Cdd:cd17943 74 IHDVFKKIgKKLEGLKCEVFIGGTPVKED-KKKLKGCHIAVGTPGRIKQLIELGALNVSHVRLFVLDEADKLMEGSFQKD 152
|
170 180
....*....|....*....|....*..
gi 1985382941 423 MKKLIScpGMPSkdRRQTLMFSATFPE 449
Cdd:cd17943 153 VNWIFS--SLPK--NKQVIAFSATYPK 175
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
517-598 |
1.70e-28 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 108.84 E-value: 1.70e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 517 DFIATFLCQEKIPTTSIHGDREQREREEALWDFRSGKCPVLVATSVAARGLDIEKVQHVINFDLPSTIDEYVHRIGRTGR 596
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
|
..
gi 1985382941 597 CG 598
Cdd:smart00490 81 AG 82
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
253-459 |
4.07e-27 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 109.09 E-value: 4.07e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 253 FEEANLCQTLNKNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILaHMMKDGVtashfreqQEPECI 332
Cdd:cd18045 1 FETMGLREDLLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVL-QCLDIQV--------RETQAL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 333 IVAPTRELINQI---FLEARKF---SYGTCIrpvviyGGTQTGHSIRQIMQGCNILCATPGRLMDIIGKEKIGLRKVRYL 406
Cdd:cd18045 72 ILSPTRELAVQIqkvLLALGDYmnvQCHACI------GGTSVGDDIRKLDYGQHIVSGTPGRVFDMIRRRSLRTRHIKML 145
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1985382941 407 VLDEADRMLDMGFgpemKKLISCPGMPSKDRRQTLMFSATFPEEIQRLSGEFL 459
Cdd:cd18045 146 VLDEADEMLNKGF----KEQIYDVYRYLPPATQVVLVSATLPQDILEMTNKFM 194
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
253-460 |
4.39e-26 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 105.99 E-value: 4.39e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 253 FEEANLCQTLNKNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMKdgvtashfrEQQEPECI 332
Cdd:cd18046 1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQIDT---------SLKATQAL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 333 IVAPTRELINQI---------FLEARKFSygtCIrpvviyGGTQTGHSIRQIMQGCNILCATPGRLMDIIGKEKIGLRKV 403
Cdd:cd18046 72 VLAPTRELAQQIqkvvmalgdYMGIKCHA---CI------GGTSVRDDAQKLQAGPHIVVGTPGRVFDMINRRYLRTDYI 142
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1985382941 404 RYLVLDEADRMLDMGFGPEMKKLIScpGMPSKdrRQTLMFSATFPEEIQRLSGEFLK 460
Cdd:cd18046 143 KMFVLDEADEMLSRGFKDQIYDIFQ--KLPPD--TQVVLLSATMPNDVLEVTTKFMR 195
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
239-451 |
1.61e-21 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 93.93 E-value: 1.61e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 239 VEVSGLDPPP---AILTFEEANLCQTLNKNIAKAGYLKLTPVQKYSIPIILAG--RDLMACAQTGSGKTAAFLLPILAHm 313
Cdd:cd18048 3 VEVLQRDPTSplfSVKSFEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSR- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 314 mkdgVTAshfrEQQEPECIIVAPTRELINQ---IFLEARKFsygtCIRPVVIYG--GTQTGHSIRQIMQgcnILCATPGR 388
Cdd:cd18048 82 ----VDA----LKLYPQCLCLSPTFELALQtgkVVEEMGKF----CVGIQVIYAirGNRPGKGTDIEAQ---IVIGTPGT 146
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1985382941 389 LMDIIGKEK-IGLRKVRYLVLDEADRMLDM-GFGPEMKKLIScpGMPSKdrRQTLMFSATFPEEI 451
Cdd:cd18048 147 VLDWCFKLRlIDVTNISVFVLDEADVMINVqGHSDHSVRVKR--SMPKE--CQMLLFSATFEDSV 207
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
264-458 |
2.60e-20 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 90.90 E-value: 2.60e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 264 KNIAKAGYLKL------TPVQKYSIPIILAGR----------------DLMACAQTGSGKTAAFLLPILAHMMKDGVTAS 321
Cdd:cd17965 15 IKEILKGSNKTdeeikpSPIQTLAIKKLLKTLmrkvtkqtsneepkleVFLLAAETGSGKTLAYLAPLLDYLKRQEQEPF 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 322 HFREQQE--------PECIIVAPTRELINQIFLEARKFSYGTCIRPVVIYGGTQTGH--SIRQIMQGCNILCATPGRLMD 391
Cdd:cd17965 95 EEAEEEYesakdtgrPRSVILVPTHELVEQVYSVLKKLSHTVKLGIKTFSSGFGPSYqrLQLAFKGRIDILVTTPGKLAS 174
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1985382941 392 IIGKEKIGLRKVRYLVLDEADRMLDMGFGPEMKKLIScPGMPSKDrrqtLMF-SATFPEEIQRLSGEF 458
Cdd:cd17965 175 LAKSRPKILSRVTHLVVDEADTLFDRSFLQDTTSIIK-RAPKLKH----LILcSATIPKEFDKTLRKL 237
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
487-604 |
4.95e-20 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 94.80 E-value: 4.95e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 487 QYSKREKLVEILQSIR----DERTMVFVETKKKADFIATFLCQEKIPTTSIHG--DRE------QREREEALWDFRSGKC 554
Cdd:COG1111 333 EHPKLSKLREILKEQLgtnpDSRIIVFTQYRDTAEMIVEFLSEPGIKAGRFVGqaSKEgdkgltQKEQIEILERFRAGEF 412
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1985382941 555 PVLVATSVAARGLDIEKVQHVINFDL-PSTIdEYVHRIGRTGRcGNIGKAI 604
Cdd:COG1111 413 NVLVATSVAEEGLDIPEVDLVIFYEPvPSEI-RSIQRKGRTGR-KREGRVV 461
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
287-613 |
2.49e-19 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 92.01 E-value: 2.49e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 287 AGRDLMACAQTGSGKTAAFLLpILAHMMKDGVTashfreqqepecIIVAPTRELINQIFLEARKFsygtcirpvviYGGT 366
Cdd:COG1061 99 GGGRGLVVAPTGTGKTVLALA-LAAELLRGKRV------------LVLVPRRELLEQWAEELRRF-----------LGDP 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 367 QTGHSIRQImqGCNILCATPGRLMDIIGKEKIGlRKVRYLVLDEADRmldmGFGPEMKKLIScpGMPSKDRrqtLMFSAT 446
Cdd:COG1061 155 LAGGGKKDS--DAPITVATYQSLARRAHLDELG-DRFGLVIIDEAHH----AGAPSYRRILE--AFPAAYR---LGLTAT 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 447 ------FPEEIQRLSG-------------EFLKP-EYLFVAVG-----QVGGACSDVQQTVLQVSQYSKREKLVEILQSI 501
Cdd:COG1061 223 pfrsdgREILLFLFDGivyeyslkeaiedGYLAPpEYYGIRVDltderAEYDALSERLREALAADAERKDKILRELLREH 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 502 RD-ERTMVFVETKKKADFIATFLCQEKIPTTSIHGDREQREREEALWDFRSGKCPVLVATSVAARGLDIEKVQHVINFDL 580
Cdd:COG1061 303 PDdRKTLVFCSSVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVAILLRP 382
|
330 340 350
....*....|....*....|....*....|...
gi 1985382941 581 PSTIDEYVHRIGRTGRCGNIGKAISFFDSISDS 613
Cdd:COG1061 383 TGSPREFIQRLGRGLRPAPGKEDALVYDFVGND 415
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
285-608 |
2.11e-18 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 88.66 E-value: 2.11e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 285 ILAGRDLMACAQTGSGKTAAFLLPILahmMKDGVTashfreqqepecIIVAPtreLI----NQI-FLEARKfsygtcIRP 359
Cdd:COG0514 29 VLAGRDALVVMPTGGGKSLCYQLPAL---LLPGLT------------LVVSP---LIalmkDQVdALRAAG------IRA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 360 VVIYGgTQTGHSIRQIMQGCN-----ILCATPGRLM-----DIIGKEKIGLrkvryLVLDEA--------DrmldmgFGP 421
Cdd:COG0514 85 AFLNS-SLSAEERREVLRALRagelkLLYVAPERLLnprflELLRRLKISL-----FAIDEAhcisqwghD------FRP 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 422 E---MKKLI-SCPGMPskdrrqTLMFSATFPEE-----IQRLSgefLKPEYLFVAvgqvggacS-D---VQQTVLQVSQY 488
Cdd:COG0514 153 DyrrLGELReRLPNVP------VLALTATATPRvradiAEQLG---LEDPRVFVG--------SfDrpnLRLEVVPKPPD 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 489 SKREKLVEILQSIRDERTMVFVETKKKADFIATFLCQEKIPTTSIHGDREQREREEALWDFRSGKCPVLVATSvaARGLD 568
Cdd:COG0514 216 DKLAQLLDFLKEHPGGSGIVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVATI--AFGMG 293
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1985382941 569 IEK--VQHVINFDLPSTIDEYVHRIGRTGRCGNIGKAISFFD 608
Cdd:COG0514 294 IDKpdVRFVIHYDLPKSIEAYYQEIGRAGRDGLPAEALLLYG 335
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
488-593 |
2.64e-16 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 76.09 E-value: 2.64e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 488 YSKREKLVEILQSIRDE----RTMVFVETKKKADFIATFLCQEKIPTTSIHGD---------------REQREREEALWD 548
Cdd:cd18802 6 IPKLQKLIEILREYFPKtpdfRGIIFVERRATAVVLSRLLKEHPSTLAFIRCGfligrgnssqrkrslMTQRKQKETLDK 85
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 1985382941 549 FRSGKCPVLVATSVAARGLDIEKVQHVINFDLPSTIDEYVHRIGR 593
Cdd:cd18802 86 FRDGELNLLIATSVLEEGIDVPACNLVIRFDLPKTLRSYIQSRGR 130
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
490-604 |
5.38e-15 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 78.76 E-value: 5.38e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 490 KREKLVEILQSI----RDERTMVFVETKKKADFIATFLCQEKIPTTSIHG--DRE------QREREEALWDFRSGKCPVL 557
Cdd:PRK13766 348 KLEKLREIVKEQlgknPDSRIIVFTQYRDTAEKIVDLLEKEGIKAVRFVGqaSKDgdkgmsQKEQIEILDKFRAGEFNVL 427
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1985382941 558 VATSVAARGLDIEKVQHVINFD-LPSTIdEYVHRIGRTGRcGNIGKAI 604
Cdd:PRK13766 428 VSTSVAEEGLDIPSVDLVIFYEpVPSEI-RSIQRKGRTGR-QEEGRVV 473
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
252-455 |
1.16e-14 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 73.22 E-value: 1.16e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 252 TFEEANLCQTLNKNIAKAGYLKLTPVQKYSIPIILAG--RDLMACAQTGSGKTAAFLLPILAHMmkDGVTashfreqQEP 329
Cdd:cd18047 2 SFEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAMLSQV--EPAN-------KYP 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 330 ECIIVAPTRELINQ---IFLEARKFSygtcirPVVIYGGTQTGHSI-RQIMQGCNILCATPGRLMDIIGKEK-IGLRKVR 404
Cdd:cd18047 73 QCLCLSPTYELALQtgkVIEQMGKFY------PELKLAYAVRGNKLeRGQKISEQIVIGTPGTVLDWCSKLKfIDPKKIK 146
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1985382941 405 YLVLDEADRMLDMGfGPEMKKLISCPGMPSKdrRQTLMFSATFPEEIQRLS 455
Cdd:cd18047 147 VFVLDEADVMIATQ-GHQDQSIRIQRMLPRN--CQMLLFSATFEDSVWKFA 194
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
255-604 |
9.08e-14 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 74.87 E-value: 9.08e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 255 EANLCQTLNKNIAKAGYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMKD-GVTAshfreqqepecII 333
Cdd:COG1205 38 PDWLPPELRAALKKRGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEALLEDpGATA-----------LY 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 334 VAPTRELIN-QifLEA-RKF--SYGTCIRPVVIYGGTqTGHSIRQIMQGCNILCATPgrlmDII------GKEKIG--LR 401
Cdd:COG1205 107 LYPTKALARdQ--LRRlRELaeALGLGVRVATYDGDT-PPEERRWIREHPDIVLTNP----DMLhygllpHHTRWArfFR 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 402 KVRYLVLDEAD--RmldmG-FGPEMKKLIscpgmpskdRR------------QTLMFSATF--PEEI-QRLSGEflkPey 463
Cdd:COG1205 180 NLRYVVIDEAHtyR----GvFGSHVANVL---------RRlrricrhygsdpQFILASATIgnPAEHaERLTGR---P-- 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 464 lFVAVGQVGGAC---------SDVQQTVLQVSQYSKREKLVEILqSIRDERTMVFVETKKKADFIATFL---CQEKIPTT 531
Cdd:COG1205 242 -VTVVDEDGSPRgertfvlwnPPLVDDGIRRSALAEAARLLADL-VREGLRTLVFTRSRRGAELLARYArraLREPDLAD 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1985382941 532 SIHGDR------EQREREEALwdfRSGKCPVLVATSVAARGLDIEKVQHVINFDLPSTIDEYVHRIGRTGRCGNIGKAI 604
Cdd:COG1205 320 RVAAYRagylpeERREIERGL---RSGELLGVVSTNALELGIDIGGLDAVVLAGYPGTRASFWQQAGRAGRRGQDSLVV 395
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
490-596 |
9.50e-14 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 68.92 E-value: 9.50e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 490 KREKLVEIL-------QSIRDERTMVFVETKKKADFIATFLCQEKI---PTTSI-HGDRE------QREREEALWDFRSG 552
Cdd:cd18801 10 KLEKLEEIVkehfkkkQEGSDTRVIIFSEFRDSAEEIVNFLSKIRPgirATRFIgQASGKsskgmsQKEQKEVIEQFRKG 89
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 1985382941 553 KCPVLVATSVAARGLDIEKVQHVINFD-LPSTIdEYVHRIGRTGR 596
Cdd:cd18801 90 GYNVLVATSIGEEGLDIGEVDLIICYDaSPSPI-RMIQRMGRTGR 133
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
266-561 |
4.76e-13 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 72.24 E-value: 4.76e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 266 IAKAGYLKLTPVQKYSIP-IILAGRDLMACAQTGSGKTAAFLLPILAHMMKDGvtashfreqqepECIIVAPTRELINQI 344
Cdd:COG1204 15 LKERGIEELYPPQAEALEaGLLEGKNLVVSAPTASGKTLIAELAILKALLNGG------------KALYIVPLRALASEK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 345 FLEARKF--SYGtcIRPVVIYGGTQtghSIRQIMQGCNILCATPGRLMDIIGKEKIGLRKVRYLVLDEAdRML-DMGFGP 421
Cdd:COG1204 83 YREFKRDfeELG--IKVGVSTGDYD---SDDEWLGRYDILVATPEKLDSLLRNGPSWLRDVDLVVVDEA-HLIdDESRGP 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 422 --EM---KKLISCPGMpskdrrQTLMFSATF--PEEIQR-LSGEFLKPEYlfVAVGQVGGACSDVQQTVLQVSQYSKREK 493
Cdd:COG1204 157 tlEVllaRLRRLNPEA------QIVALSATIgnAEEIAEwLDAELVKSDW--RPVPLNEGVLYDGVLRFDDGSRRSKDPT 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 494 LVEILQSIRDE-RTMVFVETKKKA-----------------------DFIATFLCQEKIPTTSI--------------HG 535
Cdd:COG1204 229 LALALDLLEEGgQVLVFVSSRRDAeslakkladelkrrltpeereelEELAEELLEVSEETHTNekladclekgvafhHA 308
|
330 340
....*....|....*....|....*...
gi 1985382941 536 D--REQREREEALwdFRSGKCPVLVATS 561
Cdd:COG1204 309 GlpSELRRLVEDA--FREGLIKVLVATP 334
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
494-607 |
2.33e-12 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 64.54 E-value: 2.33e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 494 LVEILQSIRDERTMVFVETKKKADFIATFLCQEKIPTTSIHGDREQREREEALWDFRSGKCPVLVATSvaARGLDIEK-- 571
Cdd:cd18794 21 LKRIKVEHLGGSGIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVATV--AFGMGIDKpd 98
|
90 100 110
....*....|....*....|....*....|....*.
gi 1985382941 572 VQHVINFDLPSTIDEYVHRIGRTGRCGNIGKAISFF 607
Cdd:cd18794 99 VRFVIHYSLPKSMESYYQESGRAGRDGLPSECILFY 134
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
489-592 |
4.67e-12 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 63.65 E-value: 4.67e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 489 SKREKLVEILQSIRD--ERTMVFVETKKKADFIATFLCQEKIPTTSIHGDREQREREEALWDFRSG-KCPV-LVATSVAA 564
Cdd:cd18793 11 GKLEALLELLEELREpgEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDpDIRVfLLSTKAGG 90
|
90 100 110
....*....|....*....|....*....|....
gi 1985382941 565 RGLDIEKVQHVINFDLP--STIDEY----VHRIG 592
Cdd:cd18793 91 VGLNLTAANRVILYDPWwnPAVEEQaidrAHRIG 124
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
474-594 |
5.77e-12 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 69.10 E-value: 5.77e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 474 ACSDVQQTVLQVSQY----SKREKLVEILQSI--RDERTMVFVETKKKADFIATFLCQEKIPTTSIHGDREQREREEALW 547
Cdd:COG0553 514 ICSHPALLLEEGAELsgrsAKLEALLELLEELlaEGEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVD 593
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1985382941 548 DFRSGK-CPV-LVATSVAARGLDIEKVQHVINFDLP-------STIDEyVHRIGRT 594
Cdd:COG0553 594 RFQEGPeAPVfLISLKAGGEGLNLTAADHVIHYDLWwnpaveeQAIDR-AHRIGQT 648
|
|
| SF2_C_UvrB |
cd18790 |
C-terminal helicase domain of the UvrB family helicases; Excinuclease ABC subunit B (or UvrB) ... |
502-613 |
5.69e-10 |
|
C-terminal helicase domain of the UvrB family helicases; Excinuclease ABC subunit B (or UvrB) plays a central role in nucleotide excision repair (NER). Together with other components of the NER system, like UvrA, UvrC, UvrD (helicase II), and DNA polymerase I, it recognizes and cleaves damaged DNA in a multistep ATP-dependent reaction. UvrB is critical for the second phase of damage recognition by verifying the nature of the damage and forming the pre-incision complex. Its ATPase site becomes activated in the presence of UvrA and damaged DNA. Its activity is strand destabilization via distortion of the DNA at lesion site, with very limited DNA unwinding. UvrB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350177 [Multi-domain] Cd Length: 171 Bit Score: 58.80 E-value: 5.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 502 RDERTMVFVETKKKADFIATFLCQEKIPTTSIHGDREQREREEALWDFRSGKCPVLVATSVAARGLDIEKVQHVINFD-- 579
Cdd:cd18790 26 RGERVLVTTLTKRMAEDLTEYLQELGVKVRYLHSEIDTLERVEIIRDLRLGEFDVLVGINLLREGLDLPEVSLVAILDad 105
|
90 100 110
....*....|....*....|....*....|....*...
gi 1985382941 580 ----LPSTiDEYVHRIGRTGRCGNiGKAISFFDSISDS 613
Cdd:cd18790 106 kegfLRSE-TSLIQTIGRAARNVN-GKVILYADKITDS 141
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
274-411 |
8.31e-10 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 58.43 E-value: 8.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 274 LTPVQKYSI-PIILAGRDLMACAQTGSGKTAAFLLPILAHmmkdgvtashfREQQEPECIIVAPTRELINQIFLEARKFS 352
Cdd:cd17921 2 LNPIQREALrALYLSGDSVLVSAPTSSGKTLIAELAILRA-----------LATSGGKAVYIAPTRALVNQKEADLRERF 70
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 353 YGTCIRPVVIYGGTQTGhsiRQIMQGCNILCATPGRLMDIIGKEKI-GLRKVRYLVLDEA 411
Cdd:cd17921 71 GPLGKNVGLLTGDPSVN---KLLLAEADILVATPEKLDLLLRNGGErLIQDVRLVVVDEA 127
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
270-608 |
1.17e-09 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 61.27 E-value: 1.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 270 GYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILahmMKDGVTashfreqqepecIIVAPTREL----INQif 345
Cdd:PRK11057 22 GYQQFRPGQQEIIDAVLSGRDCLVVMPTGGGKSLCYQIPAL---VLDGLT------------LVVSPLISLmkdqVDQ-- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 346 LEARKFSyGTCIrpvviyGGTQTGHSIRQIMQGCN-----ILCATPGRLM--DIIgkEKIGLRKVRYLVLDEADRMLDMG 418
Cdd:PRK11057 85 LLANGVA-AACL------NSTQTREQQLEVMAGCRtgqikLLYIAPERLMmdNFL--EHLAHWNPALLAVDEAHCISQWG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 419 --FGPEMKKL----ISCPGMP--------SKDRRQTLMFSATFPEEIQRLSgEFLKPeylfvavgqvggacsDVQQTVlq 484
Cdd:PRK11057 156 hdFRPEYAALgqlrQRFPTLPfmaltataDDTTRQDIVRLLGLNDPLIQIS-SFDRP---------------NIRYTL-- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 485 VSQYSKREKLVEILQSIRDERTMVFVETKKKADFIATFLCQEKIPTTSIHGDREQREREEALWDFRSGKCPVLVATsvAA 564
Cdd:PRK11057 218 VEKFKPLDQLMRYVQEQRGKSGIIYCNSRAKVEDTAARLQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVAT--VA 295
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1985382941 565 RGLDIEK--VQHVINFDLPSTIDEYVHRIGRTGRCGNIGKAISFFD 608
Cdd:PRK11057 296 FGMGINKpnVRFVVHFDIPRNIESYYQETGRAGRDGLPAEAMLFYD 341
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
278-411 |
2.38e-09 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 57.21 E-value: 2.38e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 278 QKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMKD-GVTAshfreqqepecIIVAPTRELINQIFLEARKF--SYG 354
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPILEALLRDpGSRA-----------LYLYPTKALAQDQLRSLRELleQLG 73
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1985382941 355 TCIRPVVIYGGTQTGHSIRQIMQGCNILCATPGRLMDII----GKEKIGLRKVRYLVLDEA 411
Cdd:cd17923 74 LGIRVATYDGDTPREERRAIIRNPPRILLTNPDMLHYALlphhDRWARFLRNLRYVVLDEA 134
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
288-446 |
3.77e-09 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 55.87 E-value: 3.77e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 288 GRDLMACAQTGSGKTAAFLLPILAHMmkdgvtashfrEQQEPECIIVAPTRELINQIFLEARKFsYGTCIRPVVIYGGTQ 367
Cdd:cd00046 1 GENVLITAPTGSGKTLAALLAALLLL-----------LKKGKKVLVLVPTKALALQTAERLREL-FGPGIRVAVLVGGSS 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 368 TGHSIRQIMQGCNILCATPGRL-MDIIGKEKIGLRKVRYLVLDEADRMLDMGFGPEMKKLISCPGMPsKDRRQTLMfSAT 446
Cdd:cd00046 69 AEEREKNKLGDADIIIATPDMLlNLLLREDRLFLKDLKLIIVDEAHALLIDSRGALILDLAVRKAGL-KNAQVILL-SAT 146
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
273-446 |
5.08e-08 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 53.19 E-value: 5.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 273 KLTPVQKYSIPIILAG------RDLMACAQTGSGKTAAFLLPILAhmmkdgVTASHFReqqepeCIIVAPTRELINQIFL 346
Cdd:cd17918 15 SLTKDQAQAIKDIEKDlhspepMDRLLSGDVGSGKTLVALGAALL------AYKNGKQ------VAILVPTEILAHQHYE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 347 EARKFSygTCIRPVVIYGGTQTghsirQIMQGCNILCATPGRLMDIIGKEKIGLrkvryLVLDEADRmldmgFGPEMKKL 426
Cdd:cd17918 83 EARKFL--PFINVELVTGGTKA-----QILSGISLLVGTHALLHLDVKFKNLDL-----VIVDEQHR-----FGVAQREA 145
|
170 180
....*....|....*....|
gi 1985382941 427 ISCPGMPSkdrrqTLMFSAT 446
Cdd:cd17918 146 LYNLGATH-----FLEATAT 160
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
274-595 |
7.25e-08 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 55.88 E-value: 7.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 274 LTPVQKYSIPIILAGRDLMACAQTGSGKT-AAFlLPILAHMMKDGVTASHfreQQEPECIIVAPTRELINQI------FL 346
Cdd:COG1201 25 PTPPQREAWPAIAAGESTLLIAPTGSGKTlAAF-LPALDELARRPRPGEL---PDGLRVLYISPLKALANDIernlraPL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 347 EARKFSYGTCIRPVVIygGTQTG---HSIRQIM--QGCNILCATPGRLMDII----GKEKigLRKVRYLVLDEA------ 411
Cdd:COG1201 101 EEIGEAAGLPLPEIRV--GVRTGdtpASERQRQrrRPPHILITTPESLALLLtspdAREL--LRGVRTVIVDEIhalags 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 412 -------------DRMLDMGFgpemkkliscpgmpskdRRQTLmfSATF--PEEIQR-LSGEFLKPEYLFVAVGqvGGAC 475
Cdd:COG1201 177 krgvhlalslerlRALAPRPL-----------------QRIGL--SATVgpLEEVARfLVGYEDPRPVTIVDAG--AGKK 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 476 SDVqQTVLQVSQYSKR--------EKLVE-ILQSIRDER-TMVFVETKKKADFIATFLCqEKIPTTSI-----HG--DRE 538
Cdd:COG1201 236 PDL-EVLVPVEDLIERfpwaghlwPHLYPrVLDLIEAHRtTLVFTNTRSQAERLFQRLN-ELNPEDALpiaahHGslSRE 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1985382941 539 QRER-EEALwdfRSGKCPVLVATSVAARGLDIEKVQHVINFDLPSTIDEYVHRIGRTG 595
Cdd:COG1201 314 QRLEvEEAL---KAGELRAVVATSSLELGIDIGDVDLVIQVGSPKSVARLLQRIGRAG 368
|
|
| cas3_core |
TIGR01587 |
CRISPR-associated helicase Cas3; This model represents the highly conserved core region of an ... |
290-598 |
1.80e-07 |
|
CRISPR-associated helicase Cas3; This model represents the highly conserved core region of an alignment of Cas3, a protein found in association with CRISPR repeat elements in a broad range of bacteria and archaea. Cas3 appears to be a helicase, with regions found by pfam00270 (DEAD/DEAH box helicase) and pfam00271 (Helicase conserved C-terminal domain). Some but not all members have an N-terminal HD domain region (pfam01966) that is not included within this model.
Pssm-ID: 273707 [Multi-domain] Cd Length: 359 Bit Score: 53.61 E-value: 1.80e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 290 DLMACAQTGSGKTAAFLLpILAHMMKdgvtashfrEQQEPECIIVAPTRELINQIFLEARK-FSYGTcirpvviyGGTQT 368
Cdd:TIGR01587 1 LLVIEAPTGYGKTEAALL-WALHSIK---------SQKADRVIIALPTRATINAMYRRAKElFGSEL--------VGLHH 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 369 GHSIRQIM----------------QGCNILCATPGRL--MDIIGKEKIGLRKVRY----------LVLDEADRMLdmgfg 420
Cdd:TIGR01587 63 SSSFSRIKemgdseefehlfplyiHSNDKLFLDPITVctIDQVLKSVFGEFGHYEftlasianslLIFDEVHFYD----- 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 421 PEMKKLISCPGMPSKDRRQTLM-FSATFPEEIQRlsgEFLKPEYLFVAVGQV--GGACSDVQQTVLQVSQY-SKREKLVE 496
Cdd:TIGR01587 138 EYTLALILAVLEVLKDNDVPILlMSATLPKFLKE---YAEKIGYVEFNEPLDlkEERRFENHRFILIESDKvGEISSLER 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 497 ILQSIRDE-RTMVFVETKKKADFIATFLcQEKIPTTSI---HG-----DREQREREEALWDFRSGKCPVLVATSVAARGL 567
Cdd:TIGR01587 215 LLEFIKKGgSIAIIVNTVDRAQEFYQQL-KEKAPEEEIilyHSrftekDRAKKEAELLREMKKSNEKFVIVATQVIEASL 293
|
330 340 350
....*....|....*....|....*....|....*
gi 1985382941 568 DiekvqhvINFDL----PSTIDEYVHRIGRTGRCG 598
Cdd:TIGR01587 294 D-------ISADVmiteLAPIDSLIQRLGRLHRYG 321
|
|
| Cas3 |
COG1203 |
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; ... |
295-593 |
1.99e-07 |
|
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; CRISPR-Cas type I system-associated endonuclease/helicase Cas3 is part of the Pathway/BioSystem: CRISPR-Cas system
Pssm-ID: 440816 [Multi-domain] Cd Length: 535 Bit Score: 54.32 E-value: 1.99e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 295 AQTGSGKTAAFLLPILAHMmkdgvtashfREQQEPECIIVAPTRELINQIFLEARKFSYGTcirpVVIYGGTQTGHSIRQ 374
Cdd:COG1203 154 APTGGGKTEAALLFALRLA----------AKHGGRRIIYALPFTSIINQTYDRLRDLFGED----VLLHHSLADLDLLEE 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 375 IMQGCN---------------ILCATPGRLMDII-----GKEKIGLR---KVryLVLDEADrMLDmgfgPEMKKLIscpg 431
Cdd:COG1203 220 EEEYESearwlkllkelwdapVVVTTIDQLFESLfsnrkGQERRLHNlanSV--IILDEVQ-AYP----PYMLALL---- 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 432 mpskdrRQTLMF-----------SATFPEEIQrlsgEFLKPEYLFVavgqvggaCSDVQQTVLQVSQYSKR--------- 491
Cdd:COG1203 289 ------LRLLEWlknlggsvilmTATLPPLLR----EELLEAYELI--------PDEPEELPEYFRAFVRKrvelkegpl 350
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 492 ------EKLVEILQSirDERTMVFVETKKKAdfIATF-LCQEKIPTTSIH--------GDREQRErEEALWDFRSGKCPV 556
Cdd:COG1203 351 sdeelaELILEALHK--GKSVLVIVNTVKDA--QELYeALKEKLPDEEVYllhsrfcpADRSEIE-KEIKERLERGKPCI 425
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1985382941 557 LVATSVAARGLDiekvqhvINFDL----PSTIDEYVHRIGR 593
Cdd:COG1203 426 LVSTQVVEAGVD-------IDFDVvirdLAPLDSLIQRAGR 459
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
502-596 |
2.80e-07 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 50.34 E-value: 2.80e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 502 RDERTMVFVETKKKADFIAT---FLCQEKIPTTSI---HG--DREQREREEAlwDFRSGKCPVLVATSVAARGLDIEKVQ 573
Cdd:cd18796 37 RHKSTLVFTNTRSQAERLAQrlrELCPDRVPPDFIalhHGslSRELREEVEA--ALKRGDLKVVVATSSLELGIDIGDVD 114
|
90 100
....*....|....*....|...
gi 1985382941 574 HVINFDLPSTIDEYVHRIGRTGR 596
Cdd:cd18796 115 LVIQIGSPKSVARLLQRLGRSGH 137
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
556-608 |
3.20e-07 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 48.08 E-value: 3.20e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1985382941 556 VLVATSVAARGLDIEKVQHVINFDLPSTIDEYVHRIGRTGRCGNIGKAISFFD 608
Cdd:cd18785 25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDEGEVILFV 77
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
271-410 |
5.35e-07 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 52.97 E-value: 5.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 271 YLKLTPVQKYSIPIILAGRDLMACAQTGSGKT-AAFLlpilahmmkdGVTASHFREQQEPE------CIIVAPTRELINQ 343
Cdd:PRK13767 30 FGTFTPPQRYAIPLIHEGKNVLISSPTGSGKTlAAFL----------AIIDELFRLGREGEledkvyCLYVSPLRALNND 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 344 IF--LE---------ARKFSYG-TCIRPVVIYGGTQTGHSIRQIMQGCNILCATPGRLMDIIG----KEKigLRKVRYLV 407
Cdd:PRK13767 100 IHrnLEeplteireiAKERGEElPEIRVAIRTGDTSSYEKQKMLKKPPHILITTPESLAILLNspkfREK--LRTVKWVI 177
|
...
gi 1985382941 408 LDE 410
Cdd:PRK13767 178 VDE 180
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
288-410 |
3.54e-06 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 47.58 E-value: 3.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 288 GRDLMACAQTGSGKTAAFLLPILAHMMKDGVTASHfreqqepeCIIVAPTRELINQIF--LEArkfsYGTCI---RPVVI 362
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAFLPALSSLADEPEKGVQ--------VLYISPLKALINDQErrLEE----PLDEIdleIPVAV 68
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1985382941 363 YGGtQTGHSIRQIM--QGCNILCATPGRLMDIIGKEKIG--LRKVRYLVLDE 410
Cdd:cd17922 69 RHG-DTSQSEKAKQlkNPPGILITTPESLELLLVNKKLRelFAGLRYVVVDE 119
|
|
| SF2_C_EcoAI-like |
cd18799 |
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family ... |
500-593 |
3.75e-06 |
|
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family is composed of helicase restriction enzymes, including the HsdR subunit of restriction-modification enzymes such as Escherichia coli type I restriction enzyme EcoAI R protein (R.EcoAI). The EcoAI enzyme recognizes 5'-GAGN(7)GTCA-3'. The HsdR or R subunit is required for both nuclease and ATPase activities, but not for modification. These proteins are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350186 [Multi-domain] Cd Length: 116 Bit Score: 46.40 E-value: 3.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 500 SIRDERTMVFVETKKKADFIATFLCQEKIPTTSIHGDREQRERE-EALWDFRSG--KCPVLVATSVAARGLDIEKVQHVI 576
Cdd:cd18799 3 KYVEIKTLIFCVSIEHAEFMAEAFNEAGIDAVALNSDYSDRERGdEALILLFFGelKPPILVTVDLLTTGVDIPEVDNVV 82
|
90
....*....|....*....
gi 1985382941 577 nFDLP--STIdEYVHRIGR 593
Cdd:cd18799 83 -FLRPteSRT-LFLQMLGR 99
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
270-453 |
1.58e-05 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 46.37 E-value: 1.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 270 GYLKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILahmMKDGVTashfreqqepecIIVAPTRELIN--QIFLE 347
Cdd:cd17920 9 GYDEFRPGQLEAINAVLAGRDVLVVMPTGGGKSLCYQLPAL---LLDGVT------------LVVSPLISLMQdqVDRLQ 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 348 ARkfsygtCIRPVVIyGGTQTGHSIRQIMQGC-----NILCATPGRLMDIIGKEKIG----LRKVRYLVLDEADRMLDMG 418
Cdd:cd17920 74 QL------GIRAAAL-NSTLSPEEKREVLLRIkngqyKLLYVTPERLLSPDFLELLQrlpeRKRLALIVVDEAHCVSQWG 146
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1985382941 419 --FGPEMKKLIS----CPGMPskdrrqTLMFSATFPEEIQR 453
Cdd:cd17920 147 hdFRPDYLRLGRlrraLPGVP------ILALTATATPEVRE 181
|
|
| SF2_C_XPB |
cd18789 |
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ... |
489-610 |
3.11e-05 |
|
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350176 [Multi-domain] Cd Length: 153 Bit Score: 44.55 E-value: 3.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 489 SKREKLVEILQSIRD-ERTMVFVETKKKADFIATFLcqeKIPttSIHGDREQREREEALWDFRSGKCPVLVATSVAARGL 567
Cdd:cd18789 34 NKLRALEELLKRHEQgDKIIVFTDNVEALYRYAKRL---LKP--FITGETPQSEREEILQNFREGEYNTLVVSKVGDEGI 108
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 1985382941 568 DI--EKVQHVINFDLPSTiDEYVHRIGRTGRCGNIGKAISFFDSI 610
Cdd:cd18789 109 DLpeANVAIQISGHGGSR-RQEAQRLGRILRPKKGGGKNAFFYSL 152
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
289-410 |
8.07e-05 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 44.27 E-value: 8.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 289 RDLMACAQTGSGKTAAFLLPILAHMMKDGVTASHfreqqEPECIIVAPTRELINQIFLEAR-KFSyGTCIRPVVIYGGTQ 367
Cdd:cd18023 18 KNFVVSAPTGSGKTVLFELAILRLLKERNPLPWG-----NRKVVYIAPIKALCSEKYDDWKeKFG-PLGLSCAELTGDTE 91
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1985382941 368 TGhSIRQImQGCNILCATPGR--LMDIIGKEKIGL-RKVRYLVLDE 410
Cdd:cd18023 92 MD-DTFEI-QDADIILTTPEKwdSMTRRWRDNGNLvQLVALVLIDE 135
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
289-411 |
1.12e-04 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 43.79 E-value: 1.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 289 RDLMACAQTGSGKT--AAFLLPILAHMmkdgvtashFREQQEPECIIV--APTRELINQIFLEARKFSYGTCIrpvVIYG 364
Cdd:cd18034 17 RNTIVVLPTGSGKTliAVMLIKEMGEL---------NRKEKNPKKRAVflVPTVPLVAQQAEAIRSHTDLKVG---EYSG 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1985382941 365 GTQTGHSIRQIMQGC----NILCATPGRLMDIIGKEKIGLRKVRYLVLDEA 411
Cdd:cd18034 85 EMGVDKWTKERWKEElekyDVLVMTAQILLDALRHGFLSLSDINLLIFDEC 135
|
|
| DEXHc_Hef |
cd18035 |
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs ... |
284-413 |
3.47e-04 |
|
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. All archaea encode a protein of the XPF/MUS81/FANCM family of endonucleases. It exists in two forms: a long form, referred as Hef which consists of an N-terminal helicase fused to a C-terminal nuclease and is specific to euryarchaea and a short form, referred as XPF which lacks the helicase domain and is specific to crenarchaea and thaumarchaea. Hef has the unique feature of having both active helicase and nuclease domains. This domain configuration is highly similar with the human FANCM, a possible ortholog of archaeal Hef proteins. Hef is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350793 [Multi-domain] Cd Length: 181 Bit Score: 42.12 E-value: 3.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 284 IILAGRDL----MACAQTGSGKTAAFLLPILAHMMKDGvtashfreqqePECIIVAPTRELINQIFLEARKFSygTCIRP 359
Cdd:cd18035 8 VLIAAVALngntLIVLPTGLGKTIIAILVAADRLTKKG-----------GKVLILAPSRPLVEQHAENLKRVL--NIPDK 74
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1985382941 360 VVIYGGTQTGHSIRQIMQGCNILCATPGRLMDIIGKEKIGLRKVRYLVLDEADR 413
Cdd:cd18035 75 ITSLTGEVKPEERAERWDASKIIVATPQVIENDLLAGRITLDDVSLLIFDEAHH 128
|
|
| DEXHc_Brr2_2 |
cd18021 |
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type ... |
294-428 |
8.34e-04 |
|
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350779 [Multi-domain] Cd Length: 191 Bit Score: 41.09 E-value: 8.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 294 CAQTGSGKTAAFLLPILAhmmkdgvtasHFREQQEPECIIVAPTRELINQIFLE-ARKFSYGTCIRPVVIYGGTQTghSI 372
Cdd:cd18021 25 GAPTGSGKTVCAELALLR----------HWRQNPKGRAVYIAPMQELVDARYKDwRAKFGPLLGKKVVKLTGETST--DL 92
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1985382941 373 RQIMQGcNILCATPGRLmDIIG---KEKIGLRKVRYLVLDEAdRMLDMGFGPEMKKLIS 428
Cdd:cd18021 93 KLLAKS-DVILATPEQW-DVLSrrwKQRKNVQSVELFIADEL-HLIGGENGPVYEVVVS 148
|
|
| SF2_C_Hrq |
cd18797 |
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role ... |
505-599 |
1.29e-03 |
|
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. HrQ family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350184 [Multi-domain] Cd Length: 146 Bit Score: 39.55 E-value: 1.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 505 RTMVFVETKKKADFIATFLCQEKIPT----TSIHGDR-----EQREREEAlwDFRSGKCPVLVATSVAARGLDIEKVQHV 575
Cdd:cd18797 37 KTIVFCRSRKLAELLLRYLKARLVEEgplaSKVASYRagylaEDRREIEA--ELFNGELLGVVATNALELGIDIGGLDAV 114
|
90 100
....*....|....*....|....
gi 1985382941 576 INFDLPSTIDEYVHRIGRTGRCGN 599
Cdd:cd18797 115 VLAGYPGSLASLWQQAGRAGRRGK 138
|
|
| DEXHc_Brr2_1 |
cd18019 |
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD ... |
270-410 |
1.47e-03 |
|
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350777 [Multi-domain] Cd Length: 214 Bit Score: 40.43 E-value: 1.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 270 GYLKLTPVQKYSIPIILAGRD-LMACAQTGSGKTAAFLLPILAHMMKD-----GVTASHFReqqepeCIIVAPTRELINQ 343
Cdd:cd18019 14 GFKSLNRIQSKLFPAAFETDEnLLLCAPTGAGKTNVALLTILREIGKHrnpdgTINLDAFK------IVYIAPMKALVQE 87
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1985382941 344 IF--LEARKFSYGTCIRPVviyggtqTG-HSI--RQIMQgCNILCATPGRlMDII---GKEKIGLRKVRYLVLDE 410
Cdd:cd18019 88 MVgnFSKRLAPYGITVAEL-------TGdQQLtkEQISE-TQIIVTTPEK-WDIItrkSGDRTYTQLVRLIIIDE 153
|
|
| DEXHc_cas3 |
cd17930 |
DEXH/Q-box helicase domain of Cas3; CRISPR-associated (Cas) 3 is a nuclease-helicase ... |
288-351 |
1.58e-03 |
|
DEXH/Q-box helicase domain of Cas3; CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350688 [Multi-domain] Cd Length: 186 Bit Score: 39.97 E-value: 1.58e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1985382941 288 GRDLMACAQTGSGKTAAFLLPILahmmkdgvtaSHFREQQEPECIIVAPTRELINQIFLEARKF 351
Cdd:cd17930 1 PGLVILEAPTGSGKTEAALLWAL----------KLAARGGKRRIIYALPTRATINQMYERIREI 54
|
|
| SF2_C_RecG_TRCF |
cd18792 |
C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family ... |
533-569 |
3.05e-03 |
|
C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family contains recombination factor RecG and transcription-repair coupling factor TrcF. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350179 [Multi-domain] Cd Length: 160 Bit Score: 38.79 E-value: 3.05e-03
10 20 30
....*....|....*....|....*....|....*..
gi 1985382941 533 IHGDREQREREEALWDFRSGKCPVLVATSVAARGLDI 569
Cdd:cd18792 66 LHGKMTEDEKEAVMLEFREGEYDILVSTTVIEVGIDV 102
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
272-449 |
3.39e-03 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 38.81 E-value: 3.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 272 LKLTPVQKYSIPIILAGRDL--------MAcaqTGSGKTAafllpILAHMMkdgvtASHFREQQEPECIIVAPTRELINQ 343
Cdd:pfam04851 2 LELRPYQIEAIENLLESIKNgqkrglivMA---TGSGKTL-----TAAKLI-----ARLFKKGPIKKVLFLVPRKDLLEQ 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 344 IFLEARKFSYGTCIRPVVIYGGTQtghsiRQIMQGCNILCATPGRLMDIIGKEKIGLRKVRYLVL--DEADRmldmGFGP 421
Cdd:pfam04851 69 ALEEFKKFLPNYVEIGEIISGDKK-----DESVDDNKIVVTTIQSLYKALELASLELLPDFFDVIiiDEAHR----SGAS 139
|
170 180
....*....|....*....|....*...
gi 1985382941 422 EMKKLISCpgmpSKDRRQtLMFSATFPE 449
Cdd:pfam04851 140 SYRNILEY----FKPAFL-LGLTATPER 162
|
|
| SF2_C_RecG |
cd18811 |
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a ... |
533-593 |
3.68e-03 |
|
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a critical role in recombination and DNA repair. RecG helps process Holliday junction intermediates to mature products by catalyzing branch migration. It is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350198 [Multi-domain] Cd Length: 159 Bit Score: 38.48 E-value: 3.68e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1985382941 533 IHGDREQREREEALWDFRSGKCPVLVATSVAARGLDIEK-----VQHVINFDLpSTIDEYVHRIGR 593
Cdd:cd18811 67 LHGRLKSDEKDAVMAEFREGEVDILVSTTVIEVGVDVPNatvmvIEDAERFGL-SQLHQLRGRVGR 131
|
|
| DEXHc_RIG-I |
cd17927 |
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I ... |
286-413 |
3.91e-03 |
|
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I family include FANCM, dicer, Hef, and the RIG-I-like receptors. Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). Hef (helicase-associated endonuclease fork-structure) is involved in stalled replication fork repair. RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprises RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). The RIG-I family is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350685 [Multi-domain] Cd Length: 201 Bit Score: 39.34 E-value: 3.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 286 LAGRDLMACAQTGSGKTAAFLLPILAHMMKdgvtashFREQQEPECIIVAPTRELINQiflEARKFSYGTCIRP---VVI 362
Cdd:cd17927 15 LKGKNTIICLPTGSGKTFVAVLICEHHLKK-------FPAGRKGKVVFLANKVPLVEQ---QKEVFRKHFERPGykvTGL 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1985382941 363 YGGTQTGHSIRQIMQGCNILCATPGRLM-DIIGKEKIGLRKVRYLVLDEADR 413
Cdd:cd17927 85 SGDTSENVSVEQIVESSDVIIVTPQILVnDLKSGTIVSLSDFSLLVFDECHN 136
|
|
| PRK05298 |
PRK05298 |
excinuclease ABC subunit UvrB; |
494-613 |
9.05e-03 |
|
excinuclease ABC subunit UvrB;
Pssm-ID: 235395 [Multi-domain] Cd Length: 652 Bit Score: 39.26 E-value: 9.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985382941 494 LVEILQSI-RDERTMVFVETKKKADFIATFLCQEKIPTTSIHGDREQREREEALWDFRSGKCPVLVATSVAARGLDIEKV 572
Cdd:PRK05298 436 LSEIRKRVaKGERVLVTTLTKRMAEDLTDYLKELGIKVRYLHSDIDTLERVEIIRDLRLGEFDVLVGINLLREGLDIPEV 515
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1985382941 573 QHVINFD------LPSTideyvhR-----IGRTGRcgNI-GKAISFFDSISDS 613
Cdd:PRK05298 516 SLVAILDadkegfLRSE------RsliqtIGRAAR--NVnGKVILYADKITDS 560
|
|
| |
