|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
111-493 |
6.25e-150 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 433.57 E-value: 6.25e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 111 VIKITYFLTALDLTCMFMQFGIVPYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGSLCFL 190
Cdd:cd17331 1 VLLIVHLNIVLYATCYWLQQPVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 191 LLSVSISVPLLFLSRVPGTFIHGLPGAQMVITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILTTKFGVGVACYVAVA 270
Cdd:cd17331 81 LLAFASSVPMLFLSRLPSVFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 271 GYLACALMALLCIPSQTKPQSKRSEAqqGTSQPSSVFSLQEIIRLLTLPGVMDVFLIKVLSVFPTGMFLIMFSIISIDFF 350
Cdd:cd17331 161 GSLLSIVLVILLIPSNTKSKREKEAK--ESASPPSVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 351 GLEVAHAGYLMSYNGILQMVVQGLVIGRLTSRYTERSLLMLSVIVLCGVGIAMVLMTNVFHYCLIVPPMVFSFSIVGVIT 430
Cdd:cd17331 239 GLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVI 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1974198025 431 DIILTKSVPVSDTGAMLGISASVTPLIRTFGPTIGGFLYRQFGVSSFGYLQLMVNVSLFFYLL 493
Cdd:cd17331 319 TSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLTVYLL 381
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
116-494 |
1.84e-52 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 181.24 E-value: 1.84e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 116 YFLTALDLTCMFMQFGIVPYLAT---NLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGSLCFLLL 192
Cdd:cd17330 2 FLVVFLDALGFGIVFPVLPFYVRefnKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 193 SVSISVPLLFLSR-VPGTFIHGLPGAQMVITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILTTKFGVGVACYVAvag 271
Cdd:cd17330 82 GLSRNLWLLFLARfLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVA--- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 272 ylacALMALLCIpsqtkpqskrseaqqgtsqpssvfslqeIIRLLTLPGVMDVFLIKVLSVFPTGMFLIMFSIISIDFFG 351
Cdd:cd17330 159 ----AALALLNL----------------------------VLVLFFLPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFG 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 352 LEVAHAGYLMSYNGILQMVVQGLVIGRLTSRYTERSLLMLSVIVLCGVGIAMVLMTNVFHYCLIVPPMVFSFSIVGVITD 431
Cdd:cd17330 207 FSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALS 286
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1974198025 432 IILTKSVPVSDTGAMLGISASVTPLIRTFGPTIGGFLYRQFGVSSFGYLQLMVNVSLFFYLLK 494
Cdd:cd17330 287 ALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
116-496 |
1.54e-44 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 160.08 E-value: 1.54e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 116 YFLTALDLTCMFMQFGIVPYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGSLCFLLLSVS 195
Cdd:cd17390 2 YLVGFLDLFGVSMILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 196 ISVPLLFLSRVP-GTFIHGLPGAQMVITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILT-TKFGVGVACYVAVAGYL 273
Cdd:cd17390 82 TSLALLFLSRIPlGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAeTDGGFYYVALLCSAIFI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 274 ACALMALLCIPSqtkpqskrseaqqgtsqpssvfslqeiirlltlpgVMDVFLIKVLSVFPTGMFLIMFSIISIDFFGLE 353
Cdd:cd17390 162 LNAGLVWFLLSK-----------------------------------LWDLLLVRFLMGFSVLLFRSNFSLYLEERFDLS 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 354 VAHAGYLMSYNGILQMVVQGLViGRLTSRYTERSLLML--SVIVLCGVGIAMVLMTNVFHYCLIVPPMVFSFSIVGVITD 431
Cdd:cd17390 207 PKTIGYLISYSGVLGALSGFLV-GRILKLYKNNEYLLLlhSFILLALSLLGLALAPSIWLLVLCLTPLSISSAVLRTCST 285
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1974198025 432 IILTKSVPVSDTGAMLGISASVTPLIRTFGPTIGGFLYrQFGVSSFGYLQLMVNVSLFFYLLKKK 496
Cdd:cd17390 286 SLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQ-EFSVSGPGLLGAVLALAAILLMLARQ 349
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
116-495 |
1.71e-36 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 138.86 E-value: 1.71e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 116 YFLTALDLTCMFMQFGIVPYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGSLCFLLLSVS 195
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 196 ISVPLLFLSRvpgtFIHGL------PGAQMVITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILTTKFGVGVACYVAV 269
Cdd:cd17325 82 TSYWQLLLAR----FLQGLasaavwPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 270 AGYLACALMALLCIPSQTKPQSKRSeaqqgtsqPSSVFSLQEIIRLLTLPGVMDVFLIKVLSVFPTGMFLIMFSIISIDF 349
Cdd:cd17325 158 ALALLALVLALLLLPEPRPPPNKRA--------VSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAEL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 350 FGLEVAHAGYLMSYNGILQMVVQGLViGRLTSRYTERSLLMLSVIVLCGVGIAMVLMTNVFHYCLIVPPMVFSFSIVGVI 429
Cdd:cd17325 230 GGLSPAQIGLLFGAQGLASALSQPPA-GKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPA 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1974198025 430 TDIILTKSVPVSDTGAMLGISASVTPLIRTFGPTIGGFLYRQFGVSS-FGYLQLMVNVSLFFYLLKK 495
Cdd:cd17325 309 TLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATpFLAAAALLLLAAVLFLLLR 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
107-453 |
4.66e-35 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 134.33 E-value: 4.66e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 107 TARWVIKITYFLTALDLTCMFMQFGIVPYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGS 186
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 187 LCFLLLSVSISVPLLFLSRvpgtFIHGL------PGAQMVITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILTTKFG 260
Cdd:COG2814 87 LGSLLCALAPSLWLLLAAR----FLQGLgagalfPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 261 VGVACYVAVAGYLACALMALLCIPSqTKPQSKRSEaqqgtsqpssvfsLQEIIRLLTLPGVMDVFLIKVLSVFPTGMFLI 340
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRLLPE-SRPAARARL-------------RGSLRELLRRPRLLLLLLLAFLLGFGFFALFT 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 341 MFSIISIDFFGLEVAHAGYLMSYNGILQMVVQgLVIGRLTSRYTERSLLMLSVIVLCGVGIAMVLMTNVFHYCLIVPPMV 420
Cdd:COG2814 229 YLPLYLQEVLGLSASAAGLLLALFGLGGVLGA-LLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLG 307
|
330 340 350
....*....|....*....|....*....|...
gi 1974198025 421 FSFSIVGVITDIILTKSVPVSDTGAMLGISASV 453
Cdd:COG2814 308 FGFGLLFPLLQALVAELAPPEARGRASGLYNSA 340
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
111-472 |
1.10e-28 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 116.97 E-value: 1.10e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 111 VIKITYFLTAldltcmfMQFGIV----PYLATNLGLD----AIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSY 182
Cdd:cd17388 3 FILVTVLLDA-------MGIGLImpvlPTLLREFVGDsadaATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 183 LAGSLCFLLLSVSISVPLLFLSRVpgtfIHGLPGAQM-----VITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILtT 257
Cdd:cd17388 76 AGAALDYLLMAFAPTLWWLYLGRI----IAGITGATGavaaaYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLL-G 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 258 KFGVGVACYVAVAGYLACALMALLCIPsQTKPQSKRSEAQQGTSQPSSvfSLQEIIRLLTLPGVMDVFLIkvlsvfptgM 337
Cdd:cd17388 151 EISPRAPFLVAAGLNGLNFLLGLFVLP-ESLPPERRRAFRWRRANPFG--SLRWLTGFPGLLGLLAVFFL---------I 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 338 FLI------MFSIISIDFFGLEVAHAGYLMSYNGILQMVVQGLVIGRLTSRYTERSLLMLSVIVLCGVGIAMVLMTNVFH 411
Cdd:cd17388 219 QLIgqvpatTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWM 298
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1974198025 412 YCLIVPPMVFSfSIVGVITDIILTKSVPVSDTGAMLGISASVTPLIRTFGPTIGGFLYRQF 472
Cdd:cd17388 299 VFPILILLALG-GIAGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAAS 358
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
114-462 |
1.40e-25 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 107.50 E-value: 1.40e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 114 ITYFLTALDLTCMFmqFGIVPYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGSLCFLLLS 193
Cdd:pfam07690 3 LAAFLAALGRSLLG--PALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 194 VSISVPLLFLSRVPGTFIHGL--PGAQMVITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILTTKFGVGVACYV-AVA 270
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGAlfPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIlAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 271 GYLACALMALLCIPSQTKPQSKRSEAQQGTSQPSSVFSLQEIIRLLTLpgvmdvflikVLSVFPTGMFLIMFSIISIDFF 350
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLA----------LLLFGFAFFGLLTYLPLYQEVL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 351 GLEVAHAGYLMSYNGILqMVVQGLVIGRLTSRYTERSLLMLSVIVLCGVGIAMVLMTNVFHYCLIVPPMV---FSFSIVG 427
Cdd:pfam07690 231 GLSALLAGLLLGLGGLL-GAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLllgFGFGLVF 309
|
330 340 350
....*....|....*....|....*....|....*
gi 1974198025 428 VITDIILTKSVPVSDTGAMLGISASVTPLIRTFGP 462
Cdd:pfam07690 310 PALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
116-490 |
3.77e-24 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 104.05 E-value: 3.77e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 116 YFLTALDLTCMFMQFGIVPYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGSLCFLLLSVS 195
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 196 ISVPLLFLSRVPGTFIHGL--PGAQMVITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILTTKFGVGvacyVAVAGYL 273
Cdd:cd06174 82 PSFWLLLLGRFLLGLGSGLidPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFG----WRAVFLI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 274 ACALMALLCIPSQTKPQSKRSEAQQGTSQPSSVFSLQEIIRLLTLPGVMDVFLIKVLSVFPTGMFLIMFSIISIDFFGLE 353
Cdd:cd06174 158 AAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 354 VAHAGYLMSYNGILQMVVqGLVIGRLTSRYTERSLLMLSVIVLCGVGIAMVLMTNVFHYCLIVP-PMVFSFSIVGVITDI 432
Cdd:cd06174 238 VAVAGLLLSLFGLAGALG-SLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLlLLGFGLGGLLPLSFA 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1974198025 433 ILTKSVPVSDTGAMLGISASVTPLIRTFGPTIGGFLYRQFGVSSFGYLQLMVNVSLFF 490
Cdd:cd06174 317 LIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAA 374
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
128-475 |
1.76e-19 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 89.98 E-value: 1.76e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 128 MQFGIVPYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSY-----LAGSLCFLLLSVSISVPLLF 202
Cdd:cd06173 17 IFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADllralLAAVLALLALLGSLSLWLLL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 203 LSrvpgTFIHGL------PGAQMVITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILTTKFGVGVACYVAVAGYLACA 276
Cdd:cd06173 97 VL----AFLLGIasaffgPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 277 LmALLCIPSQTKPQSKRSEAQQGTSqpssvfSLQEIIRLLTLPGVMDVFLIKVLSVFPTGMFLIMFSIISIDFFGLEVAH 356
Cdd:cd06173 173 L-LLLFIRRPPPAAPGESSSLLLRD------LREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 357 AGYLMSYNGIlQMVVQGLVIGRLTSRYTERSLLMLSVIVLCGVGIAMVLMTNVFHYCLIVPPMVFSFSIVGVITDIILTK 436
Cdd:cd06173 246 YGLLLAAFGV-GALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQL 324
|
330 340 350
....*....|....*....|....*....|....*....
gi 1974198025 437 SVPVSDTGAMLGISASVTPLIRTFGPTIGGFLYRQFGVS 475
Cdd:cd06173 325 RVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLS 363
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
117-502 |
5.79e-19 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 88.78 E-value: 5.79e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 117 FLTALDLTCMFMQFG----IVPYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGSLCFLLL 192
Cdd:COG2223 8 LLATLAFFLAFGVWYlwsvLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 193 SVSISVPLLFLSRVPGTFIHGL--PGAQMVITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILTTKFGVGVACYVAVA 270
Cdd:COG2223 88 ALAVSYWLLLLLGLLLGIGGGGsfAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 271 GYLACALMALLCIPSQTKPQSKRSEAqqgtsqpssvfSLQEIIRLLTLPGVMDVFLIKVLSVFPTGMFLIMFSIISIDFF 350
Cdd:COG2223 168 LLLVVAVLAWLFLRDPPAGAAAAAKA-----------SLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQF 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 351 GLEVAHAGYLMSYNGILQMVVqGLVIGRLTSRY-TERSLLMLSVIVLCGVGIAMVLMTNVFHYCLIVPPMVFSFSIVGVI 429
Cdd:COG2223 237 GLSAATAGLLAALFALLGALG-RPLGGWLSDRIgGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGA 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1974198025 430 TDIILTKSVPVSDTGAMLGISASVTPLIRTFGPTIGGFLYRQFG--VSSFGYLQLMVNVSLFFYLLKKKIPQKEE 502
Cdd:COG2223 316 VFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsyTAAFLVFAVLALVALVLTLLLYRRPRRAA 390
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
109-473 |
1.46e-17 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 84.20 E-value: 1.46e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 109 RWVIKITYFLTALDLTcMFMQFGIVpYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGSLC 188
Cdd:cd17329 1 LWVLLIGSFLNRLGFF-MVWPFMAI-YLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 189 FLLLSVSISVPLLFLSRVPGTFIHGL--PGAQMVITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILtTKFGVGVACY 266
Cdd:cd17329 79 FALLGFAHSPWLFAIALVLTGFGGGLfePASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLL-LLYSFRLLFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 267 VAVAGYLACALMALLCIPsQTKPqskRSEAQQGTSQPSSVFSLQEIIRLLTLPGVMdvFLIKVLSVFPTGMFLIMFSIIS 346
Cdd:cd17329 158 AAAVLFLLAALVLLFLLP-ETRP---KRRAAEKTEILRGYKIVLRDRAFLLFLLAS--FLISLIYFQLESTLPVYVVEIL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 347 IDFFGLevahAGYLMSYNGILQMVVQGLVIgRLTSRYTERSLLMLSvIVLCGVGIAMVLMTNVFhYCLIVPPMVFSF--S 424
Cdd:cd17329 232 GLGESL----LGLLLALNALLIVLLQFPVA-RLVERFRLRKILMIG-ILLFAIGFAVLAFANTL-AVLILAMIVLTLgeM 304
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1974198025 425 IVGVITDIILTKSVPVSDTGAMLGISASVTPLIRTFGPTIGGFLYRQFG 473
Cdd:cd17329 305 LVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLG 353
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
114-473 |
6.88e-17 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 82.23 E-value: 6.88e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 114 ITYFLTALDLTCMFMqfgIVPYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGSLCFLLLS 193
Cdd:COG2271 17 LAYFLNYLDRSNLSV---AAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 194 VSISVPLLFLSRVPGTFIHG--LPGAQMVITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILTTKFGVGVACYVAVAG 271
Cdd:COG2271 94 FATSFWQLLLLRFLLGLGEAgfFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 272 YLACALMALLCIpsqtkpqskrseaqqgtsqpssvfslqeiirlltlpgvmdvFLIKVLSVFPTGMFLIMFSIISIDFFG 351
Cdd:COG2271 174 GLLLALLRFWLL-----------------------------------------ALAYFLVYFALYGFLTWLPTYLVEVRG 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 352 LEVAHAGYLMSYNGILQMVVqGLVIGRLTSRYTERSLLMLSVIVLCGVG--IAMVLMTNVFHYCLIVPPMVFSFSIVGVI 429
Cdd:COG2271 213 LSLAQAGLLLSLPFLAGIVG-SLLGGWLSDRLGRRRKLVLAIGLLLAALalLLLALLPSPALAIALLFLAGFGLGGAFGL 291
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1974198025 430 TDIILTKSVPVSDTGAMLGISASVTPLIRTFGPTIGGFLYRQFG 473
Cdd:COG2271 292 LWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG 335
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
152-473 |
1.77e-15 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 78.08 E-value: 1.77e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 152 TFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGSLCFLLLSVSISVPLLFLSR---VPGTFIHGLPGAQMVITDLTTPA 228
Cdd:cd17355 45 TVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWgllGGGGAGTLAAVAFATVAAWWFER 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 229 KRADALGKLGLCFGIGVILGPSLGGILTTKFGVGVACYVAVAGYLACALMALLCIPSQTKPQSKRSEAQQGTSQPSSVfs 308
Cdd:cd17355 125 RRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGST-- 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 309 LQEIIRlltlpgvMDVFLIKVLSVFPTG---MFLIMFSIISIDFFGLEVAHAGYLMSYNGILQmVVQGLVIGRLTSRYTE 385
Cdd:cd17355 203 LKEALR-------SASFWLLALAFFLCGfavVGLIVHLVPYLADRGISPAAAAVALALIGLFN-IVGRLLSGWLGDRYSP 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 386 RSLLMLSVIVLcGVGIAMVLMTNVFHYCLIVPPMVFSFSIVGVI--TDIILTKSVPVSDTGAMLGISASVTPLIRTFGPT 463
Cdd:cd17355 275 RRLLAASYALR-ALGLALLLLLPFPPLALLLFAALFGLGWGATVplTAALAARYFGARSYGTLFGLVFAPHQLGSALGPW 353
|
330
....*....|
gi 1974198025 464 IGGFLYRQFG 473
Cdd:cd17355 354 LGGLLYDRTG 363
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
104-501 |
4.85e-15 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 76.82 E-value: 4.85e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 104 NMTTARWVIKITYFLTALdLTCMFMqfGIVPYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYL 183
Cdd:COG0738 5 NYRRALIAIYLLFFLWGF-ATALWG--PLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 184 AGSLCFLLLSVSISVPLLFLSRVPGTFIHGL--PGAQMVITDLtTPAKRADALGKLGLCFGIGVILGPSLGGILtTKFGV 261
Cdd:COG0738 82 LMALGLLLFALAPSYPLLLLALFLLGLGLGLldVAANPYVAAL-GPETAASRLNLLHAFFSLGALLGPLLGGLL-ILLGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 262 GVACYVAVAGYLACALMALLCIPSQTKPQSKRSEAQQGTSQPSsvfslqeIIRLLTLPGVMDVFLIKVLSVFPTGMFLIM 341
Cdd:COG0738 160 SLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAAS-------LKSLLKNPRLLLGGLAIFLYVGAEGAIGDW 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 342 FSIISIDFFGLEVAHAGYLMSYNGILQMVVQgLVIGRLTSRYTERSLLMLSvIVLCGVGIAMVLMTNVfhycliVPPMVF 421
Cdd:COG0738 233 LPLYLKDVLGLSEATAALGLSLFWGGMTIGR-FLGGFLLKRFGPVRLLRLS-ALLAAVGLLLALLAPG------PWLALI 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 422 SFSIVGVITDII------LTKSVPVSDTGAMLGISASVTPLIRTFGPTIGGFLYRQFGVS-SFGYLQLMVNVSLFFYLLK 494
Cdd:COG0738 305 GLALVGLGLSLMfptifsLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRaAFLVPLVCYLLILLLALAL 384
|
....*..
gi 1974198025 495 KKIPQKE 501
Cdd:COG0738 385 KRKRRKK 391
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
97-390 |
4.54e-14 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 72.92 E-value: 4.54e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 97 MEDKKIINMTTARWVIKITYFLTALDLTCMFMQFGIVPYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRA 176
Cdd:COG0477 1 MSSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 177 ALTLSYLAGSLCFLLLSVSISVPLLFLSRvpgtFIHGL------PGAQMVITDLTTPAKRADALGKLGLCFGIGVILGPS 250
Cdd:COG0477 81 VLLIGLLLFGLASLLCGLAPSPELLIAAR----ALQGIgagglmPGALALIAELFPARERGRALGLWGAAIGLGLALGPL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 251 LGGILTTKFGVGVACYVAVAGYLACALMALLCIPSQTKPQSKRSEAQQGTSQPSSVFSLQEIIRLLTLPGVMDVFLIkVL 330
Cdd:COG0477 157 LGGLLVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALL-LA 235
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 331 SVFPTGMFLIMFSIISIDFFGLEVAHAGYLMSYNGILQMVVQGLVIGRLTSRYTERSLLM 390
Cdd:COG0477 236 GAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
127-495 |
4.99e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 70.32 E-value: 4.99e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 127 FMQFGI----VPYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGSLCFLLLSVSISVPLLF 202
Cdd:cd17489 9 FLSFYLllpvLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 203 LSRvpgtFIHGL------PGAQMVITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILTTKFG-VGVACYVAVAGYLAC 275
Cdd:cd17489 89 VLR----LIHGIgwgaftTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGfAVLFIVAAVLALLAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 276 ALMALLCIPSQTKPQSKRSEaqqgtsqpssVFSLQEIIRLLTLPGVMDVFLikvlsvfptgMFLIMFSIIS-IDFFGLE- 353
Cdd:cd17489 165 LLVFLVKDPPPVAAEEAEAG----------TRAFRRLVEKKVLPPALILFL----------ASIAYGAISTfLPLYAAEr 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 354 -VAHAGYLMSYNGILqMVVQGLVIGRLTSRYTERSLLMLSVIVLCgVGIAMVLMTNVFHYCLIVPPMV-FSFSIVGVITD 431
Cdd:cd17489 225 gISNAGLFFTVYAIA-LLLSRPFSGKLSDRKGPKTVIIPGLLLLA-LGLLLLSFAGSPWMLLLAAVLYgLGFGLLFPALQ 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1974198025 432 IILTKSVPVSDTGAMLGISASVTPLIRTFGPTIGGFLYRQFGVSS-FGYLQLMVNVSLFFYLLKK 495
Cdd:cd17489 303 ALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAmFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
114-477 |
1.79e-12 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 68.75 E-value: 1.79e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 114 ITYFLTALDLTCMFMQFGIVPYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRA----ALTLSYLAGSLCF 189
Cdd:cd17474 3 AVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKvllpGLLLFGIGGLLCG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 190 LllsvSISVPLLFLSRvpgtFIHGL------PGAQMVITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILttkfgVGV 263
Cdd:cd17474 83 L----SDSFALLLAGR----ALQGIgaaglgPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL-----AAI 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 264 ACYVAVAGYLACALMALLCIpSQTKPQSKRSEaqqgtsQPSSVFSLQEIIRLLTLPGVMDVFLIKVLSVFPTGMFLIMFS 343
Cdd:cd17474 150 SWRYPFFLLAALIPVAFLAI-LFLLPEPKEKA------KSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLP 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 344 IISIDFFGLEVAHAGYLMSYNGILQMVVQGLVIGRLTSRYTERSLLMLSVIVLCGVGIAMVLMTNVfhYCLIVPPMVFSF 423
Cdd:cd17474 223 FLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSL--ALLLIAIVLFGL 300
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1974198025 424 SIVGVIT--DIILTKSVPVSDTGAMLGISASVTPLIRTFGPTIGGFLYRQFGVSSF 477
Cdd:cd17474 301 GLGLNLPllTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAP 356
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
110-288 |
3.59e-12 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 67.59 E-value: 3.59e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 110 WVIKITYFLTalDLTCMFMQFGIVPYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTR--AALTLSYLAGSL 187
Cdd:COG2271 183 WLLALAYFLV--YFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAAL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 188 CFLLLSVSISVPLLFLSRVPGTFIHGLPGAQM--VITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILTTKFGVGVAC 265
Cdd:COG2271 261 ALLLLALLPSPALAIALLFLAGFGLGGAFGLLwaLAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAF 340
|
170 180
....*....|....*....|...
gi 1974198025 266 YVAVAGYLACALMALLCIPSQTK 288
Cdd:COG2271 341 LLLAALALLAALLALLLLRETRK 363
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
116-492 |
4.35e-12 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 67.58 E-value: 4.35e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 116 YFLTALDLTCMFMQFGIVPYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGSLCFLLLSVS 195
Cdd:cd17477 2 LLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 196 ISVPLLFLSRvpgtFIHGLP-GAQMVITD-----LTTPAKRADALGKLGLCFGIGVILGPSLGGILTTkfgVGVACYVAV 269
Cdd:cd17477 82 DSPWVWFLLR----FVMGIGlAGLFVVSEswlnaLATNENRGRVLGLYSTVLGLGFALGPLLLALVGT---AGALPFLIA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 270 AGYLACALMALLCIPSQTKPQSKRSEaqqgtsqpssvFSLQEIIRLLTLPgvmdvflikVLSVFPTGMFL-IMFSIISID 348
Cdd:cd17477 155 AVLLLLALVPLLLTRRAAPEIEEAES-----------ISLRRLLRIAPLA---------LLGAFVAGFLEgAFYSLLPLY 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 349 F--FGLEVAHAGYLMSYNGILQMVVQgLVIGRLTSRYTERSLLMLSVIVLCGVGIAMVLMTNvFHYCLIVPPMVFSFSIV 426
Cdd:cd17477 215 GlrLGLSVAQAALLLAAFVLGGLLLQ-WPLGWLADRFDRRRVLLGCALLGALAALLLPLVPG-LPLALLVLLFLWGGAAG 292
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1974198025 427 GV--ITDIILTKSVPVSDTG---AMLGISASVTPLIrtfGPTIGGFLYRQFGVSSFGYLQLMVNVSLFFYL 492
Cdd:cd17477 293 PLytLALALAGDRLPGDELVaanAALLLLYGLGSVI---GPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
110-480 |
4.72e-12 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 67.57 E-value: 4.72e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 110 WVIKITYFLTALDLtcmFMQFGIVPYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGSLCF 189
Cdd:cd17324 2 LALALAAFAIGTTE---YVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 190 LLLSVSISVPLLFLSRVPGTFIHGL--PGAQMVITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILTTKFGVGVACYV 267
Cdd:cd17324 79 LLAALAPSFALLLLARALAGLAHGGfwAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 268 AVAGYLACALMALLCIPSQTKPqskrseaqqgtsQPSSVFSLQEIIRLLTLPGVMDVFLIKVLSVfptGMFLIMFSIISI 347
Cdd:cd17324 159 IAVLALLAALLLWRLLPSLPPK------------KPGSLGLLSSLLLLLRNPRLRLAYLITFLLF---GGFFALYTYLAP 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 348 ----DFFGLEVAHAGYLMSYnGILqMVVQGLVIGRLTSRYTERSLLMLSvIVLCGVGIAMVLM-TNVFHYCLIVPPMVFS 422
Cdd:cd17324 224 fltdVPGFSSSAIIGLLLLF-GVA-GVVGSPLAGRLADRGGRRALLIAL-LLLAAALLLLTLLgPSPLLLLVGLVLWGLG 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1974198025 423 FSIVGVITDIILTKSVPVSDTGAM--------LGISAsvtplirtfGPTIGGFLYRQFGVSSFGYL 480
Cdd:cd17324 301 FFAAHSALQTRVLRLAPEARGLASslylaaynLGGAL---------GAALGGLVLDHGGWAGVGWV 357
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
126-429 |
6.79e-12 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 66.83 E-value: 6.79e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 126 MFMQFGI------VPYLATNLGLDAIGFGYLQTFF----GILQLLGGPIfgrfADQFGTRAALtlsyLAGSLCFLLLSV- 194
Cdd:cd17320 9 ALGPLAIdmylpaLPAIARDLGASASAVQLTLSAYllgfALGQLLYGPL----SDRFGRRPVL----LAGLLLFILASLl 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 195 ---SISVPLLFLSRvpgtFIHGLPGA------QMVITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILTTKFGVGvAC 265
Cdd:cd17320 81 calASSIEQLLIAR----FLQGLGAAagsvvaRAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWR-AI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 266 YVAVAGYLACALMALLCIPSQTKPQSKRSeaqqgtsqPSSVFSLQEIIRLLTLPGVMDVFLIKVLSVFPTGMFLIMFSII 345
Cdd:cd17320 156 FVFLALLGLLLLLLVLLFLPETLPEEKRK--------PLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFI 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 346 SIDFFGLEVAHAGYLMSYNGILqMVVQGLVIGRLTSRYTERSLLMLSVIVLCGVGIAMVLMT--NVFHYCLIVPPMVFSF 423
Cdd:cd17320 228 YIEQLGLSPAQFGLLFALNAIA-LILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAAllGGLSLWPLVAPLFLIF 306
|
....*.
gi 1974198025 424 SIVGVI 429
Cdd:cd17320 307 FGFGLI 312
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
163-476 |
1.36e-11 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 66.13 E-value: 1.36e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 163 PIFGRFADQFGTRAALTLSYLAGSLCFLLLSVSISVPLLFLSRVPGTFIHGLPGAQMVITDLTTPAKRAD-ALGKLGLCF 241
Cdd:cd17391 54 PIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGYVPNATALIASQTPKEKSGwALGTLSTGV 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 242 GIGVILGPSLGGILTTKFGVGVACYVAVAGYLACALMALLCIPSQTKPQSKRSEAqqgtsqpssvfSLQEIIRLLTLPGV 321
Cdd:cd17391 134 VAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVKEDFKPVEKKKMV-----------STKEVWNSVPNPSL 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 322 MdvflikvLSVFPTGmFLIMFSIISID-FFGLEVAH-----------AGYLMSYNGILQMVVQGlVIGRLTSRYTERSLL 389
Cdd:cd17391 203 L-------ISLFVTT-FIIQLANQSIEpILTLYIRQlmgdasnlafiSGLVFSATGVSSLLSAP-RLGKLGDRIGHHRIL 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 390 MLSVIVLCGVGIAMVLMTNVFHycLIVPPMVFSFSIVGVITDI--ILTKSVPVSDTGAMLGISASVTPLIRTFGPTIGGF 467
Cdd:cd17391 274 LGALLASALLYIPQAFVQTPWQ--LGILRFLLGLATGGLLPAInsLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSA 351
|
....*....
gi 1974198025 468 LYRQFGVSS 476
Cdd:cd17391 352 IAAHFGYRA 360
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
106-473 |
1.52e-11 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 66.05 E-value: 1.52e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 106 TTARWVIKITYFLTALDLTCMFMQFG-IVPYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLA 184
Cdd:COG2807 13 RAGRWLLLLAIVLVALNLRPAITSVGpLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 185 GSLCFLLLSVSISVPLLFLsrvpGTFIHGLPGA--QMVITDLTT---PAKRADALGKLGLCFGIGVILGPSLGGILTTKF 259
Cdd:COG2807 93 LAAGLLLRSLAPSVALLLA----GTALIGAGIAvgNVLLPGLIKrwfPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAAL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 260 GVGVAcYVAVAGYLACALMALLcipsqtkPQSKRSEAQQGTSQPSSVFslqeiIRLLTLPGVMdvflikVLSVFPTGMFL 339
Cdd:COG2807 169 GWRGA-LAVWALLALLALLLWL-------PLLRRRPAAAAAAPAAASL-----RSLWRSPLAW------LLTLFFGLQSL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 340 IMFSIIS------IDfFGLEVAHAGYLMSYNGILQMVVqGLVIGRLTSRYTERSLLMLSVIVLCGVGIAMVLMTNVFHyc 413
Cdd:COG2807 230 LYYAVVAwlppilRD-AGLSAATAGLLLSLFQLAGIPG-SLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSL-- 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1974198025 414 LIVPPMVFSFSIVGVIT---DIILTKSVPVSDTGAMLGISASVTPLIRTFGPTIGGFLYRQFG 473
Cdd:COG2807 306 PWLWAVLLGLGQGGLFPlalTLIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATG 368
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
148-473 |
5.49e-11 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 64.22 E-value: 5.49e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 148 GYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGSLCFLLLSVSISVPLLFLSRVPGtfihGLPGAQM-----VIT 222
Cdd:cd17389 67 GLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVG----GISKGNVslstaIVA 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 223 DLTTPAKRADALGKLGLCFGIGVILGPSLGGILTTkfgvgVACYVAVAGYLACALMALlcipsqtkpqskrseaqqgtsq 302
Cdd:cd17389 143 DVTSPKKRSKGMALIGVAFSLGFIIGPMIGAYFAS-----FTRSLGEVFFSMPALFAL---------------------- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 303 pssVFSLQEIIRLL-----TLPGVMdvfliKVLSvFPTGMFLIMFS-------IISIDFFGLEVAHAGYLMSYNGILQMV 370
Cdd:cd17389 196 ---VLALADLLFIFfflpeTLPSNL-----RRLG-LVYFLYLFLFSgleftltFLTHQRFQYTSMQQGKMFFFIGIIMAL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 371 VQGLVIGRLTSRYTERSLLM-LSVIVLCGVGIAMVLMTNVFHYCLivppMVFSFSIVGVITdiILTKSV----PVSDTGA 445
Cdd:cd17389 267 VQGGYVRRIKPGKEKKAVLQgLILLIPAFLLIGWASSVTVLYAGL----FLYSFAAATVVP--CLTTLVsgygSDDQKGT 340
|
330 340
....*....|....*....|....*...
gi 1974198025 446 MLGISASVTPLIRTFGPTIGGFLYRQFG 473
Cdd:cd17389 341 VMGIFRSLGALARALGPIVACTVYWLAG 368
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
118-465 |
1.59e-10 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 62.60 E-value: 1.59e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 118 LTALDLTCMFMQ---FGIVPYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLS---YLAGSLcflL 191
Cdd:cd17504 1 LALAALAVMLVEtmlSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVlaiYTAGSL---L 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 192 LSVSISVPLLFLSR-VPGTFIHGLPGAQMVITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILTTKFGVGVACYVAVa 270
Cdd:cd17504 78 AAFAPNLPVLIAGRaLQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAA- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 271 gylACALMALLCIPSQTkpqskrseaqqgtsqpssvfslqeiIRLLTLPGVMDVFLIKVLSVFptGMFLIMFSIISI--- 347
Cdd:cd17504 157 ---PVAVLLAALVPLID-------------------------LRLLRRRNVLLANITALLAGF--GMFMVFQLLPQLlql 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 348 ---DFFGLEVAHAGYLMSYNGILQMVVqGLVIGRLTSRYTERSLLMLSvIVLCGVGIAMVLmtnVFHYCLIvpPMVFSFS 424
Cdd:cd17504 207 ptpTGFGLGITEAGLLLLPGALVMLIA-GPLAGRLIARVGPRRVLLIG-LVISAVGLLLLA---LLHSSLW--ALVVALL 279
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1974198025 425 IVGVITDI-------ILTKSVPVSDTGAMLGISAsvtpLIRTFGPTIG 465
Cdd:cd17504 280 LIGIGLGLafaslpnIVVESVPPDRTGIATGMNT----VLRTIGSAIG 323
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
148-439 |
4.60e-10 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 61.48 E-value: 4.60e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 148 GYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGSLCFLLLSVSISVPLLFLSRVpgtfIHGL------PGAQMVI 221
Cdd:cd17328 37 GLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRA----LVGIgeasysPIAPTII 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 222 TDLTTPAKRADALGKLGLCFGIGVILGPSLGGILTTKFGVGVACYVAVAGY-LACALMALLCIPSQTKPQSKRSEAQQGT 300
Cdd:cd17328 113 ADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRVTGVLgVLLAILLLLFVREPPRGAAEGGVMAKST 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 301 SQpSSVFSLQEIIR-----LLTLPGVMDVFLIKVLSVFPTGMFLIMFSIISID------FFGLEVAHAGYLmsynGilqm 369
Cdd:cd17328 193 AT-SFLADLKALAKnpsfiLSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLSsadvglIFGAITCIAGVL----G---- 263
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1974198025 370 VVQGLVIGRLTSRYTERSLLMLSVIVLCGVGIAMVLMTNVFH------YCLIVPPMVFSFSIVGVITDIILTKSVP 439
Cdd:cd17328 264 VLLGGILADRLRRKTPRADPLVCAVGLLAAAPFLFLALVLALsnlllaWVLLFLGEFLLSLNWAPVFAILLYVVIP 339
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
135-395 |
4.84e-10 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 61.02 E-value: 4.84e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 135 YLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTR-AALTLSYLAGSLCFLLLSVSISVPLLFLSrvpGTFIHG 213
Cdd:cd17471 22 FLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRkPLILLALLAGALGYLLFAFLRNYWVLLLV---GVVLLS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 214 LPGAQM--------VITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILTTKFGVGVACYVAVAGYLACALMALLCIPS 285
Cdd:cd17471 99 LGAAAFpqlfalarEYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPS 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 286 QTKPQSKRSEAQQGTSQPSSvfslqeiirlltlPGVMDVFLIKVLSVFPTGMFLIMFSIISIDFFGLEVAHAGYLMSYNG 365
Cdd:cd17471 179 VKPPAQKATPASSLVKAPVN-------------RRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLFGLAA 245
|
250 260 270
....*....|....*....|....*....|
gi 1974198025 366 ILQMVVQgLVIGRLTSRYTERSLLMLSVIV 395
Cdd:cd17471 246 ALEIPIM-LLAGLLAKRFGKRRLLLAGFLA 274
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
109-244 |
1.08e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 59.99 E-value: 1.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 109 RWVIKITYFLTALDLTCMFMQFGIVPYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGSLC 188
Cdd:COG2814 207 PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG 286
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1974198025 189 FLLLSVSISVPLLFLSRVPGTFIHGL--PGAQMVITDLTTPAKRADALGKLGLCFGIG 244
Cdd:COG2814 287 LLLLALAGSLWLLLLALFLLGFGFGLlfPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
132-293 |
4.12e-09 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 58.93 E-value: 4.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 132 IVPYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGSLCFLLLSVSISVPLLFLSRVPGTFI 211
Cdd:TIGR00711 24 AIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 212 HGL--PGAQMVITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILTTKFGVGVACYVAVAGYLACALMALLCIPSQTKP 289
Cdd:TIGR00711 104 GGPliPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVAFFILPRDKPA 183
|
....
gi 1974198025 290 QSKR 293
Cdd:TIGR00711 184 ASEN 187
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
115-282 |
4.26e-09 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 58.47 E-value: 4.26e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 115 TYFLTALDLTCMFMQFGIVPYLAtnlgldaigfGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGSLCFLLLSV 194
Cdd:cd06180 211 GYIITATFLPLIARETGAGSLLA----------GLLWSLFGLAAVPSCFLWGALSDRWGTRRALAANLLVQAVGVLLPLL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 195 SISVPLLFLSRVpgtfihGLPGAQMVITDLTTPAKR-------ADALGKLGLCFGIGVILGPSLGGILTTKFG-VGVACY 266
Cdd:cd06180 281 SPGPAGLVLSAV------LFGGTFMAITALVMALARelappaaPRALALMTASFGVGQILGPLLAGWLADATGgFAPALI 354
|
170
....*....|....*.
gi 1974198025 267 VAVAGYLACALMALLC 282
Cdd:cd06180 355 LAAAALVVAALLALLV 370
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
110-493 |
7.51e-09 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 57.60 E-value: 7.51e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 110 WVIKITYFLTALDLTCMFMqfGIVPYLATN-LGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFG-TRAALTLSYL---A 184
Cdd:cd17326 2 YVMYLTMFLSSLQFSIVLT--SIWPYLQKIdPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILiaiV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 185 GSLCFLLLSV--SISVPLLFLSRvpgtFIHGLpGAQMV------ITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILT 256
Cdd:cd17326 80 GNILYALAEYfpSNRKYVMLVAR----FLIGV-GAGNVavlrayVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFT 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 257 T--KFGVGVACYVAVAGYLACA-LMALLCIPSQtkpqskrseaqqgtsqpssvfslqeiirLLTLPGVMDVFLIKVlsvf 333
Cdd:cd17326 155 PigYPGYVIGIKLRFNMYTAPAwLMAILGIINI----------------------------ILILFFFKEVVCIFL---- 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 334 ptgMFLIMF---------SIISIDFFGLEVAHA----GYLMSYNGILQMVVQGLVIGRLTSRYTERSLLMLSVIvlcgVG 400
Cdd:cd17326 203 ---FFVVLFifanletigTPLTMDMYGWTREEAvlynGIILAVSGVLSVLVFLLFKFLSLGLIDERKILLGGLI----LF 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 401 IAMVLMTNVFHYCLIVpPMVFSFSIVGVITDIILTKSVPVSDTGAMLGISASVTPLIRTFGPTIGGFLYRQFGVSSFGYL 480
Cdd:cd17326 276 FLGFVVTLPWGITGVI-LFGLGYPIGNVMLYTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFVTAIYTHFGPRWTWII 354
|
410
....*....|...
gi 1974198025 481 QLMVNVSLFFYLL 493
Cdd:cd17326 355 TLGLLLLAIILLI 367
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
114-465 |
9.06e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 57.18 E-value: 9.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 114 ITYFLTALDLTCMFMqfgIVPYLATNLGLDAIGFGYLQT----FFGILQLlggpIFGRFADQFGTRAALTLSYLAGSLCF 189
Cdd:cd17321 3 LAVFLAALDVTIVNV---ALPTIARDLGASPSQLQWVVNayllAFAALLL----LAGRLGDRFGRKRVFLIGLALFGLAS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 190 LLLSVSISVPLLFLSRVpgtfIHGL------PGAQMVITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILTTKFGVGV 263
Cdd:cd17321 76 LLCALAPSLAFLIAARA----LQGIgaaaimPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRW 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 264 ACYVAVAgylACALMALLCipsqtkpqskrseaqqgtsqpssvfslqeiirlltlPGVMDVFLIKVLSVFPTGMFLIMFS 343
Cdd:cd17321 152 IFLINVP---IGLVALLLA------------------------------------RTFSGAVLAAFLLGAALGGLLFLLP 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 344 IISIDFFGLEVAHAGYLMSYNGILqMVVQGLVIGRLTSRYTERSLLMLSVIVLCGVGIAMVLMTNVFHYCLIVPPMVFSF 423
Cdd:cd17321 193 LYLQGVLGYSPLQAGLALLPLALA-MLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLG 271
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1974198025 424 ----SIVGVITDIILTkSVPVSDTGAMLGISASVtpliRTFGPTIG 465
Cdd:cd17321 272 lglgLFATPLTNAALS-SVPKEKAGAASGILNTA----RQLGGALG 312
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
163-282 |
2.02e-08 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 56.03 E-value: 2.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 163 PIFGRFADQFGTRAALTLS---YLAGSLcflLLSVSISVPLLFLSRVpgtfIHGL------PGAQMVITDLTTPAKRADA 233
Cdd:cd17502 48 PIYGKLSDLFGRKWVLLIAiviFELGSL---LCGLAPNMTMLIVGRA----IQGIgggglmSLAFIIIADLVPPRERGKY 120
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1974198025 234 LGKLGLCFGIGVILGPSLGGILTTKFG----------VGVACYVAVAGYLACALMALLC 282
Cdd:cd17502 121 QGYIGAVFGIASVAGPLIGGAFTDHLSwrwcfyinlpIGGLALALLRTILLSSIFGFLF 179
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
104-473 |
2.92e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 56.06 E-value: 2.92e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 104 NMTTARWVIKITYFLTAL--DLTCMFMQFGIVPYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTR-----A 176
Cdd:COG2211 3 AKKKLSLKEKLAYGLGDLglNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgrrrP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 177 ALTLSYLAGSLCFLLLSVSISVP----------LLFLSRVPGTFIhgLPGAQMVITDLTT-PAKRADALGKLGLCFGIGV 245
Cdd:COG2211 83 WILIGAIPLALSFVLLFTAPDLSptgkliyalvTYLLLGLAYTLV--NIPYSALGAELTPdYEERTRLSSWRFAFAGLGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 246 ILGPSLGGILTTKFGVGVACYVAVAGYLACALMALLCIPS--QTKpqskrsEAQQGTSQPSSVFslQEIIRLLTLPGVMD 323
Cdd:COG2211 161 LLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTffGTK------ERPVPEEEKVSLK--ESLKALLKNRPFLL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 324 VFLIKVLSVFPTGMFLIMFSIISIDFFGLEVAHAGYLMSYNGILQMVVQgLVIGRLTSRYTERSLLMLSVIVLCGVGIAM 403
Cdd:COG2211 233 LLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGA-PLWPRLAKRFGKKKAFIIGLLLAALGLLLL 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1974198025 404 VLMTNVFHYCLIVPPMVFSF--SIVGVITDIILTKSVPVSD-------TGAMLGISASVTPLIRTFGPTIGGFLYRQFG 473
Cdd:COG2211 312 FFLGPGNLWLLLVLAALAGIglGAILVLPWAMLADVVDYDEwktgrrrEGLYFGIFTFAIKLGQALAGALAGLLLALFG 390
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
133-465 |
6.69e-08 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 54.50 E-value: 6.69e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 133 VPYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGSLCFLLLSVSISVPLLFLSRVPGTFIH 212
Cdd:cd17503 19 LPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 213 GL--PGAQMVITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILTTKFGVGVACYVAvagyLACALMALLCIPsqtkpq 290
Cdd:cd17503 99 GVliPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYIN----LPIGILALLLAP------ 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 291 skrseaqqgtsqpssvfslqeIIRLltlpgvmDVFLIKVLSVFPTGMFLIMFSIISIDF---------FGLEVAHAGYLM 361
Cdd:cd17503 169 ---------------------LLDL-------RLFKDRNFTLGLLLSFLLGLGLFGAMFllplylqnvLGYSAFESGLVL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 362 SYNGILQMVVQGLViGRLTSRYTERSLLMLSVIVLcgvGIAMVLMTNVFHYC----LIVPPMVFSFSIVGVITDI--ILT 435
Cdd:cd17503 221 APGGLASAILSPLV-GRLLDKFGPRLLLLAGLLLL---ALGTLLLAFLTPDTslwlIILPLFIRGLGMGLVFMPLntLAL 296
|
330 340 350
....*....|....*....|....*....|
gi 1974198025 436 KSVPVSDTGAMlgisASVTPLIRTFGPTIG 465
Cdd:cd17503 297 NSLPPEQIGDA----TALFNTIRQLGGSIG 322
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
132-281 |
6.99e-08 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 54.67 E-value: 6.99e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 132 IVPYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGSLCFLLLSVSISVP-LLFLSRVPGTF 210
Cdd:TIGR00895 39 AAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTqLLILRFLAGLG 118
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1974198025 211 IHGLPGAQMVITDLTTPAK-RADALGKLGLCFGIGVILGPSLGGILTTKFGVGVACYVavaGYLACALMALL 281
Cdd:TIGR00895 119 LGGLMPNLNALVSEYAPKRfRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYV---GGIAPLLLLLL 187
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
111-493 |
8.10e-08 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 54.13 E-value: 8.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 111 VIKITYFLtaldltcMFMQFG-IVPYLAT---NLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFG-TRAALTLSYLAG 185
Cdd:cd17335 1 RLKLFYFF-------FFAALGsLLPFLSVylkQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 186 SLCFLLLS-VSISVPLLFLSRVPGTFIHglpGAQMVITD---LTTPAKRADALGKLGLCFGIGVILGPSLGGILTTKFGV 261
Cdd:cd17335 74 VLFFLSLFfVAQIFWLLLLLVILGAFFS---APVVPLVDsitLQYLGEERERYGKQRLWGSIGFGIAALLVGILIDRSST 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 262 GVACYVAVAGYLACALMALLcIPSQTKPQSKRSEAQQGTSQpssvfslqeIIRLLTLPGVMDVFLIKVLSVFPTGMFlIM 341
Cdd:cd17335 151 YKNYTIAFYVFAVLMLLALL-LALKFPFRPKHPEPNENTGG---------LLALLRNPRVLAFLLVAFLMGFGHGLI-YS 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 342 FSIISIDFFGLEVAHAGYLMSYNGILQMVVQgLVIGRLTSRYTERSLLMLSVIVLCGVGIAMVLMTNvFHYCLIVPPM-V 420
Cdd:cd17335 220 FLFWHLQDLGGSKTLIGLLWTVGVVSEIPFF-FFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLEN-PWLVLPIELLhG 297
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1974198025 421 FSFSIVGVITDIILTKSVPVSDTGAMLGI-SASVTPLIRTFGPTIGGFLYRQFG-VSSFGYLQLMVNVSLFFYLL 493
Cdd:cd17335 298 LTFALVWAAAVSYASAAAPPGLRATAQGLlQGLYFGLGGGLGSLIGGYLYEAFGaRTTFRFFAIAALAGLLAFFL 372
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
91-281 |
1.09e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 53.77 E-value: 1.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 91 KEESLKMEDKKIINMTTARWVIKITYFLTALDLTCMFMQFGIVPYLA-TNLGLDAIGFGYLQTFFGILQLLGGPIFGRFA 169
Cdd:cd06173 189 SSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAkEVLGGGAAGYGLLLAAFGVGALLGALLLGRLS 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 170 DQFGTRAALTLSYLAGSLCFLLLSVSISVPLLFLsrvpGTFIHGLPGAQMVITDLT------TPAKRADALGKLGLCFGI 243
Cdd:cd06173 269 KRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLA----ALFLLGLAGGLFNVPLNTllqlrvPDELRGRVFSVYNALNSG 344
|
170 180 190
....*....|....*....|....*....|....*...
gi 1974198025 244 GVILGPSLGGILTTKFGVGVACYVAVAGYLACALMALL 281
Cdd:cd06173 345 AMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
86-284 |
2.10e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 52.94 E-value: 2.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 86 QKLELKEESLKMEDKKIINMTTARWVIKITYFLTALDLTCMFMQFGI---VPYLATNLGLDAIGFGYLQTFFGILQLLGG 162
Cdd:cd17478 168 RLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLttfLPFYLVQRGYSLVFAGLLLSLFLFAGAIGT 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 163 PIFGRFADQFGTRAALTLSYLAGSLCFLLLSVSISVPLLFLSRVPGTFIHGLPGAQMVITDLTTPAKRADALG-KLGLCF 241
Cdd:cd17478 248 LIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNVGLASGlMMGLSF 327
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1974198025 242 GIGVILGPSLgGILTTKFGVGVAcyvavagYLACALMALLCIP 284
Cdd:cd17478 328 GLGGIGAPVL-GALADAFGLESV-------LLILALLPLLGAL 362
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
160-476 |
5.55e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 51.81 E-value: 5.55e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 160 LGGPIFGRFADQFGTR----AALTLSYLAGSLCFLLlsvsISVPLLFLSRvpgtFIHGL------PGAQMVITDLTTPAK 229
Cdd:cd17473 50 LFAPLAGWLADRFGRKrlliAGLLLYGIGGVAGLFL----DSLYALLASR----ALLGIgvagimTLATALIGDYFEGEE 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 230 RADALGKLGLCFGIGVILGPSLGGILTTK-----FGVgvacYVAVagyLACALMALLCIPsqtKPQSKRSEAQQGTSQPS 304
Cdd:cd17473 122 RAKMLGLQSAAMSLGGVVFLLLGGALAEIgwrapFLV----YLLA---LPVLILVLLFLP---EPARKSKSAASPGAATA 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 305 SVFSlqeiIRLLTLPGVMDVFLIKVLSVFPTGMFLIMfsiisIDFFGLEVAHAGYLMSYNGILQMVVqGLVIGRLTSRYT 384
Cdd:cd17473 192 AALP----WKRVLPIYFLAFLAMLLFYVIPIQLPFLL-----QERGGGSAALIGLALAIASLAGAIG-ALLFGRLKRRLG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 385 ERSLLMLSVIVLcgvGIAMVLMTNVFHYCLIVPPMVFS---FSIVGVITDIILTKSVPVSDTGAMLGISAS-------VT 454
Cdd:cd17473 262 KRRLLAIGFALM---ALGFLLLALASGLWVVLLGAILAglgFGLLLPTLNSWAMSLVPPELRGRAMGIVTSafflgqfLS 338
|
330 340
....*....|....*....|..
gi 1974198025 455 PLIRTFGPTIGGFLYRQFGVSS 476
Cdd:cd17473 339 PLVLGPLVNLTGGLSGAFLILG 360
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
110-281 |
6.26e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 51.42 E-value: 6.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 110 WVIKITYFLTALdltCMFMQFGIVPYLA-----TNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLA 184
Cdd:cd17504 180 LLANITALLAGF---GMFMVFQLLPQLLqlptpTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVI 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 185 GSLCFLLLSV--SISVPLLFLSRVPGTFIHGLPGAQMVITDLTTPAKR-ADALGKLGLCFGIGVILGPSLGGILTTKFGV 261
Cdd:cd17504 257 SAVGLLLLALlhSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRtGIATGMNTVLRTIGSAIGPAIAGAILTTYTV 336
|
170 180
....*....|....*....|....*.
gi 1974198025 262 GVACYVA------VAGYLACALMALL 281
Cdd:cd17504 337 SITSGGVptegayVLAFLIGAALALA 362
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
135-280 |
7.38e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 51.39 E-value: 7.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 135 YLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGSLCFLLLSVSISVPLLFLsrvpGTFIHGL 214
Cdd:cd17370 224 LRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLL----GFILWGL 299
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1974198025 215 -PGAQ-----MVITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILTTKFGVGVACYVAVAGYLACALMAL 280
Cdd:cd17370 300 yMGAQesierAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
118-468 |
7.51e-07 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 51.47 E-value: 7.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 118 LTALDLTCMFMQFGI---VPYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGSLCFLLLSV 194
Cdd:cd17475 1 ATLAQAAASLVAQGIpalAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 195 SISVPLLFLSRVPGTFIHG--LPGAQMVITDLTTPAKRadalgklGLCFGI---GVILGPSLGGI----LTTKFGVGVAc 265
Cdd:cd17475 81 VGSYPVLLVLLFLVGAGYGsvQPGGGRAIMRWFPPRER-------GLAMGIrqtGVPLGGALAAAllppLALHYGWRAA- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 266 yVAVAGyLACALMALLCIPSQTKPQSKRSEAQqgtSQPSSVFSLQEIIRlltLPGVMDVFLIKVLSVFPTGMFLIMFSII 345
Cdd:cd17475 153 -FVVAG-LVSILAAVLFWLFYREPPAASAATE---SASTLLRSLKEVLR---NRDVWLIAIAGALLVAPQFALLTFLLLF 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 346 SIDFFGLEVAHAGYLMS---YNGILQMVVQGLVIGRLTSRYTERSLLMLSVIVLCGVgIAMVLMTNVFHYCLIVPPM-VF 421
Cdd:cd17475 225 LHDHLGLSVVAAGALLAvaqLGGALGRIGLGRVSDRVFGGRRRPVLVITAAIAAAAL-LVLSLLSPGTPLWLLVLLLiLL 303
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1974198025 422 SFSIVG--VITDIILTKSVPVSDTGAMLGISASVTPLIRTFGPTIGGFL 468
Cdd:cd17475 304 GLFAIGwnGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLL 352
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
146-493 |
1.45e-06 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 50.29 E-value: 1.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 146 GFGYLQTFFGIlqllggPiFGRFADQFGTRAALtlsyLAGSLCFLLLSV----SISVPLLFLSRvpgtFIHGLpGA---- 217
Cdd:cd17472 40 IYGLTQAIFQI------P-FGLLSDRIGRKPVI----LFGLLLFIAGSLlaayATSIYGLILGR----ALQGS-GAissv 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 218 -QMVITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILTTKFGVGVAcyvavagYLACALMALLCI--------PSQTK 288
Cdd:cd17472 104 vMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGL-------FLITAILSLVSLlillffvpDPPKI 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 289 PQSKRSEaqqgtsqPSSVFSLQEIIRLLTLpgvmdVFLIKVLSVFPTgmflIMFSIISIDFFGLEVAHAGYLMSYngiLQ 368
Cdd:cd17472 177 VQISEKE-------KKKLKKLLKNKRLLRL-----DFSIFILHFVLM----AFFYILPLLLTQLGGGKGQLWKVY---LP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 369 MVVQGLVIGRLTSRYTER----SLLMLSVIVLCGVGIAMVLMTNVFHYCLIVPPMVF--SFSIVGVITDIILTKSVPVSD 442
Cdd:cd17472 238 AILIGFILMVPFVIYAEKkgkmKQVFVSSILLIAVGFLLLLFAATSLWLLIIGLIIFfiGFNLLEALLPSLVSKIAPKEY 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1974198025 443 TGAMLGISASVTPLIRTFGPTIGGFLYRQFGVSSFGYLQLMVNVSLFFYLL 493
Cdd:cd17472 318 RGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLLVSF 368
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
137-489 |
1.82e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 50.01 E-value: 1.82e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 137 ATNLGLDAIGfgYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGSLCFLLLSVSISVPLLFLSRVPGTFIHGL-- 214
Cdd:cd17333 25 AFNLNVADVS--VIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGIld 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 215 PGAQMVITDLtTPAKRADALGKLGLCFGIGVILGPSLGG-ILTTKFGVGVACYVAVAGYLACALMALLCipsQTKPQSKR 293
Cdd:cd17333 103 TGANTFVGAL-FEESSATRLNVLHGFFGLGALIGPLIATsLLTSELSWSWAYLIIGLIYLLLAILILLT---LFPELPSA 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 294 SEAQQGTSQPSSVFslqeiIRLLTLPGVMDVFLIKVLSVFPTGMFLIMFSIISIDFFGLEVAHAGYLMSYNGILqMVVQG 373
Cdd:cd17333 179 RNPQQSVGAFSASA-----SRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVG-ITIGR 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 374 LVIGRLTSRYTERSLLMLSVIVLCGVGIAMVLMTNVFHyclivppMVFSFSIVG----VITDIILTK-----SVPVSDTG 444
Cdd:cd17333 253 LLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVV-------GLVATALLGlfmaALFPTILSLgisnlPYAKGKGT 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1974198025 445 AMLGISASVTPLIrtfGPTIGGFLYRQFGVSSFGYLQLMVNVSLF 489
Cdd:cd17333 326 SVLLAAGSIGGAI---IPFIMGFIAEAVGIQTAMLLITILYAIIF 367
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
324-493 |
2.17e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 49.72 E-value: 2.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 324 VFLIKVLSVFPTGMFLIMFSIISIDFFGLEVAHAGYLMSYNGILQMVVQgLVIGRLTSRYTERSLLMLSVIVLCGVGIAM 403
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQ-PLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 404 VLMTNVFHYCLIVPPMVFSFSIVGVITDIILTKSVPVSDTGAMLGISASVTPLIRTFGPTIGGFLYRQFGVSSFGYLQLM 483
Cdd:pfam07690 80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
|
170
....*....|
gi 1974198025 484 VNVSLFFYLL 493
Cdd:pfam07690 160 LSLLAAVLLL 169
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
134-493 |
2.26e-06 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 49.88 E-value: 2.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 134 PYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGSLCFLLLSVSISVPLLFLSRvpgtFIHG 213
Cdd:cd17319 27 PTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLR----FLLG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 214 L------PGAQMVITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILTTKFGVGVAcyvavagYLACALMALLCIpsqt 287
Cdd:cd17319 103 VaeagffPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWA-------FIIEGLLGLLLA---- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 288 kpqskrseaqqgtsqpssvfslqeIIRLLTLPGVMDVFLIKVLSVFPTGMFLIMFSIISIDFFGLEVAHAGYLMSYNGIL 367
Cdd:cd17319 172 ------------------------VLWWFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 368 qMVVQGLVIGRLTSRYTERSLLMLSVIVLCGVGIAMVLMTNVFH----YCLIVPPMVFSFSIVGVITdIILTKSVPVSDT 443
Cdd:cd17319 228 -GAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSpvvaVILLSLAGFGIGAASPVFW-SLPADLLPGEAA 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1974198025 444 GAMLGISASVTPLIRTFGPTIGGFLYRQFG--VSSFGYLQLMVNVSLFFYLL 493
Cdd:cd17319 306 ATAGGLINSGGNLGGFVAPLLIGYLVDATGsyTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
114-477 |
4.65e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 48.75 E-value: 4.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 114 ITYFLTALDLTCM-FMQFGIVPYLATNLGLDAIGFGYLQTFFGilQLLGGPIFGRFADQFGTRAALTLSYLAGSLCFLLL 192
Cdd:cd17316 6 LGWFFDAYDFFLIgFVAPVLAAEFSLGLSLLQTGLLFAAGFLG--RPIGALLFGYLGDRIGRKKALILTLLLFGLATLLI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 193 SVSISVPLLFLSR-VPGTFIHG-LPGAQMVITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILTTKFGVGVACYVAva 270
Cdd:cd17316 84 GLLPTPILLLVLRfLQGIGIGGeYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWRIL-- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 271 gYLACALMALLCIpsqtkpqskrseaqqgtsqpssvfslqeIIRLLTLPgvmdVFLIKVLSVFPTGMFLIMFSIISIDFF 350
Cdd:cd17316 162 -FLIGALPALLAL----------------------------LLRRRTLL----LILLWFFISFGYYGLTTFLPTYLQTVL 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 351 GLEVAHAGYLMSYNGILQMVVqGLVIGRLTSRYTERSLLM----LSVIVLCGVGIAMVLMTNVFHYCLIVppMVFSFSIV 426
Cdd:cd17316 209 GLSPATSSLYLLLISLGALVG-ALIAGLLSDRIGRKKTLVigliLSGILALPLFYLLSGSPTLLLLLLFI--LSFFVGGV 285
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1974198025 427 GVITDIILTKSVPVSDTGAMLGISASVTPLIRTFGPTIGGFLYRQFGVSSF 477
Cdd:cd17316 286 WGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGV 336
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
110-283 |
5.03e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 48.72 E-value: 5.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 110 WVIKITYFLTALDLTCMFMQFGIvpYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGSLCF 189
Cdd:cd17473 200 LPIYFLAFLAMLLFYVIPIQLPF--LLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGF 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 190 LLLSVSISVPLLFLSRVPGTFIHGL--PGAQMVITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILTTKFGVGVACYV 267
Cdd:cd17473 278 LLLALASGLWVVLLGAILAGLGFGLllPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFL 357
|
170
....*....|....*.
gi 1974198025 268 AVAGylACALMALLCI 283
Cdd:cd17473 358 ILGV--LALVLAIVLL 371
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
133-435 |
7.00e-06 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 48.15 E-value: 7.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 133 VPYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGSLCFLLLSVSISVPLLFLSRvpgtFIH 212
Cdd:TIGR00710 28 FPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLR----FVQ 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 213 GLPGA------QMVITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILTTKFGVGVACYVAVAGYLACALMALLCIPsQ 286
Cdd:TIGR00710 104 AFGASagsvisQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILP-E 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 287 TKPQSKRSEAqqgtSQPSSVFSLqeIIRLLTLPGVMDVFLIKVLSVFptgMFLIMFSIISIDFFGLEVAHAGYLMSYNGI 366
Cdd:TIGR00710 183 TLPYEARIQI----STYFETFLL--LLKSKMFWGYALIYGASFGGFF---AFFSGAPFVYIDIMGVSPSVFGLLFALNII 253
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1974198025 367 lQMVVQGLVIGRLTSRYTERSLLMLSVIVLC--GVGIAMVLMTNVFHYCLIVPPMVFSFSIVGVITDIILT 435
Cdd:TIGR00710 254 -AMIFGGFLNGRFIKKWGAKSLLRMGLILFAvsAVLLEITAILGLGSWAMIIGPMMFVGIGNSMISSIAMA 323
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
324-473 |
1.57e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 46.89 E-value: 1.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 324 VFLIKVLSVFPTGMFLIMFSIISIDFfGLEVAHAGYLMSYNGILQMVVQgLVIGRLTSRYTERSLLMLSVIVLCGVGIAM 403
Cdd:COG2814 15 LALGAFLSGLGIGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGA-PLAGRLADRFGRRRVLLLGLLLFALGSLLC 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 404 VLMTNVFHYCLIVPPMVFSFSIVGVITDIILTKSVPVSDTGAMLGISASVTPLIRTFGPTIGGFLYRQFG 473
Cdd:COG2814 93 ALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
160-293 |
1.73e-05 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 47.22 E-value: 1.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 160 LGGPIFGRFADQFGTRAALTLSYLAGSLCFLLLSVSISV-PLLFLSRVPGTFIHGLPGAQMVITDLTTPAKRADALGKLG 238
Cdd:PRK09874 69 IASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIwQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLS 148
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1974198025 239 LCFGIGVILGPSLGGILTTKFGVGVACYVAVAGYLACALMALLCIPSQTKPQSKR 293
Cdd:PRK09874 149 TGGVSGALLGPLAGGLLADSYGLRPVFFITASVLFLCFLVTLFCIRENFQPVSKK 203
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
132-408 |
1.95e-05 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 46.83 E-value: 1.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 132 IVPYLATNLGLD--AIGFGYLQTFFgiLQLLGGPIFGRFADQFGTRAALTLSYLAGSLCFLLLSVSISVPLLFLSrvpGT 209
Cdd:cd17353 25 FNPPLSSALGWSlaSVALAFTLTIV--FLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLG---YG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 210 FIHGLpGAQMV-ITDLTT-----PAKRADALGKLGLCFGIGVILGPSLGGILTTKFGVGVACYVAVAGYL--ACALMALL 281
Cdd:cd17353 100 VLGGI-GAGIGyITPVSTavkwfPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLiiIVIGAFLI 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 282 CIPSQTKPQSKRSEAQQGTSQPSSVFSLQEIIRlltLPGVMDVFLIKVLSVFPTGMFLIMFSIISIDFFGLEVAHAGYLM 361
Cdd:cd17353 179 RDPPKGWVPPGVDPLANNAENSPRDYTPREMLR---TPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAV 255
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1974198025 362 SYNGILQMVvqGLVIGRLTSRYTERSLLMLSVIVLCGVGIAMVLMTN 408
Cdd:cd17353 256 SILSIFNGG--GRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIG 300
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
154-473 |
2.69e-05 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 46.44 E-value: 2.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 154 FGILQL---LGGPIFGRFADQFGTRAALTLSYLAGSLCFLLLSVSISVP-------LLFLSRVpgtfIHGLPGAQMVITD 223
Cdd:cd17385 40 FGCFALvifLTSPIFGKYLVKIGAKFMFVAGMFVSGGCTILFGFLDRVPdgtvfiaLCFLVRI----VEAVGFAAFITAS 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 224 LTTPAKR-----ADALGKLGLCFGIGVILGPSLGGILTTKFGVGVACYVAVAGYLACALMALLCIPSQTKPQSKRSEAqq 298
Cdd:cd17385 116 FAIIAKEfpnniATVLGTLETFSGLGLMLGPPLGGFLYQAGGYELPFLVLGCLLLLTVPLNMFILPRYDDDPSPKSGS-- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 299 gtsqpssvfslqeIIRLLTLPGV-MDVFLIKVLSVF-----PT-GMFLIMFSIisidffglevaHAGYLmsynGILQMVV 371
Cdd:cd17385 194 -------------MLKLLKIPSVlLLCLSIVSGSVSlgfldPTlSPHLRQFKL-----------SPGQV----GLMFLIL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 372 QGL------VIGRLTSRYTERSLLMLSVIVLCGVGIAMVLMTNVFHY---------CLIVPPMVFSFSIVGVITDIILT- 435
Cdd:cd17385 246 AGSyaisapLWGWLSDKKKIPKWLMVIGSIITGVGFLLLGPAPLLPIkselwmviiGLVLLGLSLGAALVPTFPELLNCa 325
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1974198025 436 --KSVP--VSDTGAMLGISASVTPLIRTFGPTIGGFLYRQFG 473
Cdd:cd17385 326 reYGFPdnLSTYGLVSGLFNAAFSLGAFIGPTLGGFLLERLG 367
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
110-280 |
3.84e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 45.67 E-value: 3.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 110 WVIKITYFLTALDLTCMFMQFGI----VPYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAG 185
Cdd:cd17316 174 LLRRRTLLLILLWFFISFGYYGLttflPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILS 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 186 SLC--FLLLSVSISVPLLFLSRVPGTFIHGLPGAQM--VITDLTTPAKRADALG-KLGLCFGIGVILGPSLGGILTTKFG 260
Cdd:cd17316 254 GILalPLFYLLSGSPTLLLLLLFILSFFVGGVWGALyaYLAELFPTEVRATGVGlSYNLGRLGGGGAPPLIALLLASTGG 333
|
170 180
....*....|....*....|
gi 1974198025 261 VGVACYVAVAGYLACALMAL 280
Cdd:cd17316 334 TGVPALILALLAIVALIVAL 353
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
109-281 |
4.42e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 45.88 E-value: 4.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 109 RWVIKITYFLTALDLTCMFMQFGIVPYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFAD-QFGTRAALTLSYLAGSL 187
Cdd:cd06174 203 PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMAL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 188 CFLLLSVSISVPLLFLSRVPGTFIHGLPGAQM--VITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILTTKFGVGVAC 265
Cdd:cd06174 283 GLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSfaLIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGA 362
|
170
....*....|....*.
gi 1974198025 266 YVAVAGYLACALMALL 281
Cdd:cd06174 363 FLVLAVLLLLAAILLL 378
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
117-281 |
5.11e-05 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 45.67 E-value: 5.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 117 FLTALDLTCMFMQFGIV----PYLATNLGLDAIGFGYLQTFFGILQLLGGPIFG-RFADQFGTRAALTLSYLAGSLCFLL 191
Cdd:cd17490 198 FFSLLAILQQMITFSTTfgftPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGtLFYKKLGERNTIIIGFLLLGAYCFL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 192 LSVSISVPLLFLSRVPGTFihglpGAQMVITDLTTPA-------KRADALGKLGLCFGIGVILGPSLGGILTTKFGVGVA 264
Cdd:cd17490 278 IPFAPNLTLLYLLQALNGF-----GTGILFPLLMSLSiegvpaeQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTG 352
|
170
....*....|....*..
gi 1974198025 265 CYVAVAGYLACALMALL 281
Cdd:cd17490 353 FFVIGVIALLAAILSLA 369
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
133-277 |
7.56e-05 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 44.94 E-value: 7.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 133 VPYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGSLCFLLLSVSISVPLLFLSRVpgtfih 212
Cdd:cd17393 22 IPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALF------ 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1974198025 213 gLPGAQMVITDLTTPAKRAD---ALGK-----LGLCFGIGVILGpSLGGILTTKFGVGV-ACYVAVAGYLACAL 277
Cdd:cd17393 96 -LFGAANGALDVAMNAQGVAverAYGRpimssLHAMWSLGGLAG-ALLGAAAIGAGVSPgVHLLAAAVLLLLAA 167
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
132-409 |
1.00e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 44.47 E-value: 1.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 132 IVPYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGSLCFLLLSVSISVPLLFLSRVPGTFI 211
Cdd:cd17478 18 LLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 212 HGL--PGAqMVITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILTTKFGVGVACYVAVAGYLACALMALLcipsqtKP 289
Cdd:cd17478 98 SAAfhPEG-ARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLR------LR 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 290 QSKRSEAQQGTSQPSSVFSLQEIIRLLTLpgvmdVFLIKVLSVFptgmflIMFSIISidFFGLEVAHAGYLMSYNGILQM 369
Cdd:cd17478 171 PLKKPEAKKAAAKSSARSTLKGVWRALLL-----LLIIVFLRSW------VLSSLTT--FLPFYLVQRGYSLVFAGLLLS 237
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1974198025 370 V------VQGLVIGRLTSRYTERSLLMLSvivLCGVGIAMVLMTNV 409
Cdd:cd17478 238 LflfagaIGTLIGGPLSDRFGRRRVIIAS---LLLAAPFLLLFLLT 280
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
134-292 |
1.21e-04 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 44.29 E-value: 1.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 134 PYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGSLCFLLLSVSISVPLLFLSRVPGTFIHG 213
Cdd:TIGR00881 19 PYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 214 L--PGAQMVITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILTTKFGVGVACYvAVAGYLACALMALLCIPSQTKPQS 291
Cdd:TIGR00881 99 MgwPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVF-IVPGIIAIIVSLICFLLLRDSPQS 177
|
.
gi 1974198025 292 K 292
Cdd:TIGR00881 178 C 178
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
154-280 |
1.61e-04 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 43.90 E-value: 1.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 154 FGILQLLGGPIFGRFADQFGTRAALTLSYLAGSLCFLLLSVSISVPLLFLSRVpgtfihGLPGAQMVITDLTTPAKRA-- 231
Cdd:pfam06779 237 FGLAAALGVLVWLRAAKRWGTRPALTAALLIQALGVLLSLLSPSPAGLAVSSL------LFGGTFMAITSLVMQLAREla 310
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1974198025 232 -----DALGKLGLCFGIGVILGPSLGGILTTKFG-VGVACYVAVAGYLACALMAL 280
Cdd:pfam06779 311 ppaprRLLGLMTASFGIGQILGPLLASLLTAATGgLTPALLLAAAALVLAALIVL 365
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
151-247 |
5.51e-04 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 42.18 E-value: 5.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 151 QTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGSLCFLLLSVSISVPLLFLSRvpgtFIHGL------PGAQMVITDL 224
Cdd:cd17317 31 QTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLR----FLVGVtsagifTVGFVLGMEI 106
|
90 100
....*....|....*....|...
gi 1974198025 225 TTPAKRADALGKLGLCFGIGVIL 247
Cdd:cd17317 107 VGPKYRSFVGILFGLFWALGYML 129
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
110-281 |
5.75e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 42.17 E-value: 5.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 110 WVIKITYFLTALDLTcmFMQFGIVPYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAA-----LTLSYLA 184
Cdd:cd17319 182 WGLALGYFGINYALY--GLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARrlviiIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 185 GSLCFLLLSVSISVPLLFLSRVPGTFIHGLPGAQMVITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILTTKFGVGVA 264
Cdd:cd17319 260 VGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTA 339
|
170
....*....|....*..
gi 1974198025 265 CYVAVAGYLACALMALL 281
Cdd:cd17319 340 AFLFLAAVALLAALLVL 356
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
128-283 |
5.99e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 42.13 E-value: 5.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 128 MQFGIVPYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGSLC----FLLLSVSISVPLLFL 203
Cdd:cd17369 247 FTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFafpfFWLLDTGSTWLIVLA 326
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 204 SRVPGTFIHGLPGAQM--VITDLTTPAKRadaLGKLGLCFGIGVILGPSLGGILTTKFGVGVACYVAVAGYL-ACALMAL 280
Cdd:cd17369 327 AVVVLGVLHGMMYGPQaaFLAELFPTRVR---YTGASLGYQLGAILGGGFAPLIATALVAATGSWWPVALYLaALAVISL 403
|
...
gi 1974198025 281 LCI 283
Cdd:cd17369 404 VAA 406
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
123-282 |
7.33e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 41.79 E-value: 7.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 123 LTCMFMQFGIVPY----LATNLGLDAIGFGYLQTFFGILQLLGGPIFGRF-ADQFGTRAALTLSYLAGSLCFLLLSVSIS 197
Cdd:cd17474 208 FLYFFLYFAFLTYlpflLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLlKKRFGARRILVIGLLLYALSLLLLGFVPS 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 198 VPLLFLSRVPGTFIHGL--PGAQMVITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILTTKFGVGVACYVAVAGYLAC 275
Cdd:cd17474 288 LALLLIAIVLFGLGLGLnlPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAA 367
|
....*..
gi 1974198025 276 ALMALLC 282
Cdd:cd17474 368 AVLLALL 374
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
125-283 |
7.37e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 41.80 E-value: 7.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 125 CMFMQFGIV---PYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGSLCFLLLSVSISVPLL 201
Cdd:cd17365 183 GLLLVYLLNswlPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVL 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 202 FLSRVPGTFIhGLPGAQMVITDLTT---PAK-RADALGKLGLCFGIGVILGPSLGGILTTkFGVGVAcyvavAGYLACAL 277
Cdd:cd17365 263 LYVLVFLAGA-CVNGAQVGLYALAArfyPTEvRATGVGWALGVGRLGAILGPLLGGLLLA-AGLGPE-----SVFLALAI 335
|
....*.
gi 1974198025 278 MALLCI 283
Cdd:cd17365 336 PAALGA 341
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
89-283 |
8.65e-04 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 41.82 E-value: 8.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 89 ELKEESLKMEDKKIINMTTARWVIKITYFLTALDLTCMFMQFGIVPYLATNLGLDAIGFGYLQTFFGILQLL-GGPIFGR 167
Cdd:cd17331 187 ESASPPSVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVvQGLLVGP 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 168 FADQFGTRAALTLSYLAGSLCFLLLSVSISVPLLFLSRVPGTFihGLPGAQMVITDLTT----PAKRADALGKLGLCFGI 243
Cdd:cd17331 267 LTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVI--GGSVLYTVITSLLTkavpPEDTGTALGLSHALFSL 344
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1974198025 244 GVILGPSLGGILTTKFGvgvacyVAVAGYLACALMALLCI 283
Cdd:cd17331 345 VRTVSPTIGGALLQAYG------FPSFGLLGAAINGLLTV 378
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
109-469 |
1.25e-03 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 41.24 E-value: 1.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 109 RWVIKITYFLTAldltCMFMQFGIVPYLATNLGLDAIGFGYLQ-----TFFGILQLLGGPIFGRFADQFGTRAALTLSYL 183
Cdd:cd17314 1 RWFVLYVSFLLS----AMSTGFILSWSLFYQPWQDAFGYSSSQiataaSLSNLGMLLTQPILGFIADSFGPRPLMALAGI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 184 AGSLCFLLLSVSISVPLLF--LSRVPGTFIHGLPGAQMVITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILTTKFGV 261
Cdd:cd17314 77 MVLAGYTYLSYVFNSFPLSyaCFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 262 GvacyvAVAGYLACALMALLCIPSQTKPQSKRSEAQQGTSQPSSVFSLQEIIRLLtlpgVMDVFLIKVLSVFpTGMFLIM 341
Cdd:cd17314 157 A-----LVYTILGILAAIVLSVVSLLGFKEPPDNQARLHVQKKKTQTMGEIFRDK----VFWILFIAIFLVL-IGGFLFI 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 342 FSIISI--DFFGLEVAHAGYLMSYNGILQmVVQGLVIGRLTSRYTERSLLMLSVIVLCGVGIAMVLMTNVFHYCLIVPPM 419
Cdd:cd17314 227 ANMASLvrSLQLDAPSFVTKLMSIYGLFN-AFGRLLWGIVADFFGGRLSTLSILLTILGLGLCAFLFLLKMTPVGLVLTG 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1974198025 420 -VFSFSIVGVITDIILTKSVPVSD--TGAMLGISASVTPLIRTFGPTIGGFLY 469
Cdd:cd17314 306 sLLGFSYGGLFTVYPATVSTVFGTesFATLYGILLFAPAIGSILGPMLGAKFY 358
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
151-254 |
1.30e-03 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 41.12 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 151 QTFFGILQLLGGPIFGRFADQFGTRAALTLSYL----AGSLCFLLLSVSISVPLLFLSrvpGTFIHGLPG-AQMVITDLT 225
Cdd:cd17374 41 QSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLqlaiFGTCAAFAPTFPVYCVLRFLA---GFAVSGISInTLILGTEWT 117
|
90 100
....*....|....*....|....*....
gi 1974198025 226 TPAKRADALGKLGLCFGIGVILgpsLGGI 254
Cdd:cd17374 118 TPRHRALAITLTSCFFSIGQML---LAGL 143
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
125-257 |
2.31e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 40.23 E-value: 2.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 125 CMFMQFGIVP-YLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGSLCFLLLSVsISVPLLFL 203
Cdd:cd17321 183 ALGGLLFLLPlYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLAL-LGADSSVW 261
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1974198025 204 SRVPGTFIHGLpGAQMVITDLTT-------PAKRADALGKLGLCFGIGVILGPSLGGILTT 257
Cdd:cd17321 262 LLLPGLVLLGL-GLGLFATPLTNaalssvpKEKAGAASGILNTARQLGGALGVALLGALLT 321
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
130-282 |
4.26e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 39.56 E-value: 4.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 130 FGIV-PYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGSLCFLLLSVSISVPLLFLSRVPG 208
Cdd:cd17312 22 FSVAkPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLN 101
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1974198025 209 TFIHGL--PGAQMVITDLTTPAKRADALGKLGLCFGIGVILGPSLGGILTTKFGVGVACYVAVAGylaCALMALLC 282
Cdd:cd17312 102 GLFQSMgwPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIV---GLVVAIIL 174
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
110-283 |
6.83e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 38.79 E-value: 6.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 110 WVIKITYFLTALDLTCMFmqFGIVPYLATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQF--GTRAALTLSYLA--- 184
Cdd:cd17312 186 WVLSLAYAFVYIVRYACL--DWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLfgGRRAPIAVIYMLlmt 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 185 GSLCFLLLSVS---ISVPLLFLSrvpGTFIHGLpgaQMVIT-----DLTTPAKRADALGKLGLCFGIGVILGPSLGGILT 256
Cdd:cd17312 264 LSLALFWFFPHnklLSIVLLFLI---GFFVGGP---INLIGgaaaqDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYII 337
|
170 180
....*....|....*....|....*..
gi 1974198025 257 TKFGVGVACYVAVAGYLACALMALLCI 283
Cdd:cd17312 338 DHYGWSTVFYFLISAALLSVLLLLSLW 364
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
160-428 |
7.75e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 38.82 E-value: 7.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 160 LGGPIFGRFADQFGTRAALTLSYLAGSLCFLLLSVS-------ISVP-LLFLSRVPGTFIHG--LPGAQMVITDLTTPAK 229
Cdd:cd17367 55 IGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTptyatigIWAPiILLLARLLQGLSVGgeYGTSATYLSEVAPPGR 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 230 RA--------DALGKLGLCFGIGVILGPSLGGILTTKFGVGVAcyvavagYLACALMALLCI-PSQTKPQSKRSEAQQGT 300
Cdd:cd17367 135 RGfyssfqyvTLIGGQLLALGVLLVLQHTLGEDQMAAWGWRIP-------FLLGGVLAVVVLwLRRGLEETESFEAIAES 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 301 SQPSSVfSLQEIIRLLTlpGVMDVFLIKVLSVFPTGMFLIMFSIISIDFFGLEVAHAGYLMSYNGILQMVVQGLvIGRLT 380
Cdd:cd17367 208 NEASAG-TLRELRRHPR--ELLLVVGLTAGGTLAFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPL-GGRLS 283
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1974198025 381 SRYTERSLLMLSvivlcGVGiAMVLMTNVFHYCLIVPPMVFSFSIVGV 428
Cdd:cd17367 284 DRIGRRPLLLFF-----GIG-GTLATVPLLSALDHTDSPYTAFALVLV 325
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
113-281 |
9.35e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 38.30 E-value: 9.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 113 KITYFLTALDLTCMFMQFgIVPYL-----ATNLGLDAIGFGYLQTFFGILQLLGGPIFGRFADQFGTRAALTLSYLAGSL 187
Cdd:cd17352 182 DPTFVLLALGVSFAMLGF-FVPFVylpsyAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLIL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974198025 188 CFLLLSVSIS---VPLLFLSRVPGTFIHGLPGAQMVI-TDLTTPAKRADALGKLGLCFGIGVILGPSLGGILTTKFGVG- 262
Cdd:cd17352 261 GLSLLAFPLAttyVGLIVFSVLFGFCSGSYSSLTPVIlADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYd 340
|
170
....*....|....*....
gi 1974198025 263 VACYVAVAGYLACALMALL 281
Cdd:cd17352 341 AAFYFCGACLLLSGVLLFL 359
|
|
| |
