NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1958761205|ref|XP_038960698|]
View 

rab9 effector protein with kelch motifs isoform X3 [Rattus norvegicus]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 18656853)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions; similar to Mus musculus Rab9 effector protein with kelch motifs, which is a Rab9 effector required for endosome to trans-Golgi network (TGN) transport

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
73-291 2.79e-21

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 92.53  E-value: 2.79e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761205  73 GKVFIVGGANPN----QSFSDVHTMDLGTHRWdTATREGLLPRYEHASFLPScspHSIWVFGGADQSGNRNCLQVMNPEA 148
Cdd:COG3055    71 GKLYVFGGFTGAnpssTPLNDVYVYDPATNTW-TKLAPMPTPRGGATALLLD---GKIYVVGGWDDGGNVAWVEVYDPAT 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761205 149 RTWSTpevTGCPPSPRTFHTSSAAIGNHLYVFGGGErgaqpvqdvklhvFDANTLTWAQPETHgspPSPRHGHAMVAAGT 228
Cdd:COG3055   147 GTWTQ---LAPLPTPRDHLAAAVLPDGKILVIGGRN-------------GSGFSNTWTTLAPL---PTARAGHAAAVLGG 207

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958761205 229 KLFIHGGLAGdrFFDDLHCIDIGDMSWQKLGPTgtaPVGCAAHAAVAVGHHVYVFGGMTATGA 291
Cdd:COG3055   208 KILVFGGESG--FSDEVEAYDPATNTWTALGEL---PTPRHGHAAVLTDGKVYVIGGETKPGV 265
Kelch smart00612
Kelch domain;
281-326 4.13e-04

Kelch domain;


:

Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 37.92  E-value: 4.13e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1958761205  281 YVFGGMTATGALNTMYKYHTEKQHWTILqfdTSLPPGRLDHSMCVI 326
Cdd:smart00612   3 YVVGGFDGGQRLKSVEVYDPETNKWTPL---PSMPTPRSGHGVAVI 45
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
73-291 2.79e-21

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 92.53  E-value: 2.79e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761205  73 GKVFIVGGANPN----QSFSDVHTMDLGTHRWdTATREGLLPRYEHASFLPScspHSIWVFGGADQSGNRNCLQVMNPEA 148
Cdd:COG3055    71 GKLYVFGGFTGAnpssTPLNDVYVYDPATNTW-TKLAPMPTPRGGATALLLD---GKIYVVGGWDDGGNVAWVEVYDPAT 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761205 149 RTWSTpevTGCPPSPRTFHTSSAAIGNHLYVFGGGErgaqpvqdvklhvFDANTLTWAQPETHgspPSPRHGHAMVAAGT 228
Cdd:COG3055   147 GTWTQ---LAPLPTPRDHLAAAVLPDGKILVIGGRN-------------GSGFSNTWTTLAPL---PTARAGHAAAVLGG 207

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958761205 229 KLFIHGGLAGdrFFDDLHCIDIGDMSWQKLGPTgtaPVGCAAHAAVAVGHHVYVFGGMTATGA 291
Cdd:COG3055   208 KILVFGGESG--FSDEVEAYDPATNTWTALGEL---PTPRHGHAAVLTDGKVYVIGGETKPGV 265
PLN02193 PLN02193
nitrile-specifier protein
 151-319 1.25e-16

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 81.16  E-value: 1.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761205 151 WSTPEVTGCPPSPRTFHtSSAAIGNHLYVFGGGERGAQPVqDVKLHVFDANTLTWA-QPETHGSPPSPRHGHAMVAAGTK 229
Cdd:PLN02193  153 WIKVEQKGEGPGLRCSH-GIAQVGNKIYSFGGEFTPNQPI-DKHLYVFDLETRTWSiSPATGDVPHLSCLGVRMVSIGST 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761205 230 LFIHGGLAGDRFFDDLHCIDIGDMSWQKLGPTGTAPVGCAAHAAVAVGHHVYVFGGMTATGALNTMYKYHTEKQHWtilq 309
Cdd:PLN02193  231 LYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKW---- 306

                         170
                  ....*....|
gi 1958761205 310 FDTSLPPGRL 319
Cdd:PLN02193  307 FHCSTPGDSF 316
Kelch_3 pfam13415
Galactose oxidase, central domain;
174-226 2.33e-07

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 46.90  E-value: 2.33e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958761205 174 GNHLYVFGGGERGAQPVQDvKLHVFDANTLTWAQPethGSPPSPRHGHAMVAA 226
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLN-DLYVYDLDTNTWTQI---GDLPPPRSGHSATYI 49
Kelch smart00612
Kelch domain;
281-326 4.13e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 37.92  E-value: 4.13e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1958761205  281 YVFGGMTATGALNTMYKYHTEKQHWTILqfdTSLPPGRLDHSMCVI 326
Cdd:smart00612   3 YVVGGFDGGQRLKSVEVYDPETNKWTPL---PSMPTPRSGHGVAVI 45
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
281-327 2.83e-03

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 39.37  E-value: 2.83e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1958761205 281 YVFGGMTATGALNTMYKYHTEKQHWTILqfdTSLPPGRLDHSMCVIP 327
Cdd:COG3055    26 YVAGGLSGGSASNSFEVYDPATNTWSEL---APLPGPPRHHAAAVAQ 69
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 281-308 7.85e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 34.12  E-value: 7.85e-03
                          10        20
                  ....*....|....*....|....*...
gi 1958761205 281 YVFGGMTATGALNTMYKYHTEKQHWTIL 308
Cdd:pfam01344  15 YVIGGFDGNQSLNSVEVYDPETNTWSKL 42
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
73-291 2.79e-21

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 92.53  E-value: 2.79e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761205  73 GKVFIVGGANPN----QSFSDVHTMDLGTHRWdTATREGLLPRYEHASFLPScspHSIWVFGGADQSGNRNCLQVMNPEA 148
Cdd:COG3055    71 GKLYVFGGFTGAnpssTPLNDVYVYDPATNTW-TKLAPMPTPRGGATALLLD---GKIYVVGGWDDGGNVAWVEVYDPAT 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761205 149 RTWSTpevTGCPPSPRTFHTSSAAIGNHLYVFGGGErgaqpvqdvklhvFDANTLTWAQPETHgspPSPRHGHAMVAAGT 228
Cdd:COG3055   147 GTWTQ---LAPLPTPRDHLAAAVLPDGKILVIGGRN-------------GSGFSNTWTTLAPL---PTARAGHAAAVLGG 207

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958761205 229 KLFIHGGLAGdrFFDDLHCIDIGDMSWQKLGPTgtaPVGCAAHAAVAVGHHVYVFGGMTATGA 291
Cdd:COG3055   208 KILVFGGESG--FSDEVEAYDPATNTWTALGEL---PTPRHGHAAVLTDGKVYVIGGETKPGV 265
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
73-326 8.13e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 85.59  E-value: 8.13e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761205  73 GKVFIVGGANPNQSFSDVHTMDLGTHRWDTATREGLLPRYEHASFLPScspHSIWVFGGADQSGNRNCLQ----VMNPEA 148
Cdd:COG3055    23 GKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPPRHHAAAVAQD---GKLYVFGGFTGANPSSTPLndvyVYDPAT 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761205 149 RTWSTpevTGCPPSPRTFHTsSAAIGNHLYVFgGGERGAQPVQDVKlhVFDANTLTWaqpETHGSPPSPRHGH-AMVAAG 227
Cdd:COG3055   100 NTWTK---LAPMPTPRGGAT-ALLLDGKIYVV-GGWDDGGNVAWVE--VYDPATGTW---TQLAPLPTPRDHLaAAVLPD 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761205 228 TKLFIHGGLAGDRFFDdlHCIDIGDMSWQKLGPTGTAPVGcaahaavavghHVYVFGGMtaTGALNTMYKYHTEKQHWTI 307
Cdd:COG3055   170 GKILVIGGRNGSGFSN--TWTTLAPLPTARAGHAAAVLGG-----------KILVFGGE--SGFSDEVEAYDPATNTWTA 234

                         250
                  ....*....|....*....
gi 1958761205 308 LqfdTSLPPGRLDHSMCVI 326
Cdd:COG3055   235 L---GELPTPRHGHAAVLT 250
PLN02193 PLN02193
nitrile-specifier protein
 151-319 1.25e-16

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 81.16  E-value: 1.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761205 151 WSTPEVTGCPPSPRTFHtSSAAIGNHLYVFGGGERGAQPVqDVKLHVFDANTLTWA-QPETHGSPPSPRHGHAMVAAGTK 229
Cdd:PLN02193  153 WIKVEQKGEGPGLRCSH-GIAQVGNKIYSFGGEFTPNQPI-DKHLYVFDLETRTWSiSPATGDVPHLSCLGVRMVSIGST 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761205 230 LFIHGGLAGDRFFDDLHCIDIGDMSWQKLGPTGTAPVGCAAHAAVAVGHHVYVFGGMTATGALNTMYKYHTEKQHWtilq 309
Cdd:PLN02193  231 LYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKW---- 306

                         170
                  ....*....|
gi 1958761205 310 FDTSLPPGRL 319
Cdd:PLN02193  307 FHCSTPGDSF 316
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
150-322 1.87e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 75.96  E-value: 1.87e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761205 150 TWSTpevTGCPPSPRTfHTSSAAIGNHLYVFGGGERGaQPVQDVklHVFDANTLTWaqpETHGSPP-SPRHGHAMVAAGT 228
Cdd:COG3055     2 TWSS---LPDLPTPRS-EAAAALLDGKVYVAGGLSGG-SASNSF--EVYDPATNTW---SELAPLPgPPRHHAAAVAQDG 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761205 229 KLFIHGGLAGD----RFFDDLHCIDIGDMSWQKLGPtgtAPVGCAAHAAVAVGHHVYVFGGMTATGALNTMYKYHTEKQH 304
Cdd:COG3055    72 KLYVFGGFTGAnpssTPLNDVYVYDPATNTWTKLAP---MPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGT 148

                         170
                  ....*....|....*...
gi 1958761205 305 WTILqfdTSLPPGRLDHS 322
Cdd:COG3055   149 WTQL---APLPTPRDHLA 163
PLN02153 PLN02153
epithiospecifier protein
 158-300 7.54e-15

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 75.02  E-value: 7.54e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761205 158 GCPPSPRTFHtSSAAIGNHLYVFGGgERGAQPVQDVKLHVFDANTLTWAQPETHGSPPS-PRHGHAMVAAGTKLFIHGGL 236
Cdd:PLN02153   17 GKGPGPRCSH-GIAVVGDKLYSFGG-ELKPNEHIDKDLYVFDFNTHTWSIAPANGDVPRiSCLGVRMVAVGTKLYIFGGR 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958761205 237 AGDRFFDDLHCIDIGDMSWQ---KLGPTGtAPVGCAAHAAVAVGHHVYVFGGMTATGALNTMYKYHT 300
Cdd:PLN02153   95 DEKREFSDFYSYDTVKNEWTfltKLDEEG-GPEARTFHSMASDENHVYVFGGVSKGGLMKTPERFRT 160
PLN02193 PLN02193
nitrile-specifier protein
 50-288 1.59e-12

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 68.83  E-value: 1.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761205  50 GDKPCPRVGHscsyfppvGEAEKG-KVFIVGGA-NPNQSFSD-VHTMDLGTHRWDTATREGLLPryeHASFLPSCS---P 123
Cdd:PLN02193  160 GEGPGLRCSH--------GIAQVGnKIYSFGGEfTPNQPIDKhLYVFDLETRTWSISPATGDVP---HLSCLGVRMvsiG 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761205 124 HSIWVFGGADQSGNRNCLQVMNPEARTWS--TPEVTGcpPSPRTFHtSSAAIGNHLYVFGGgeRGAQpvqdVKLHVFDAN 201
Cdd:PLN02193  229 STLYVFGGRDASRQYNGFYSFDTTTNEWKllTPVEEG--PTPRSFH-SMAADEENVYVFGG--VSAT----ARLKTLDSY 299

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761205 202 TL---TWAQPETHGSPPSPRHGHAMVAAGTKLFIHGGLAGDRFfDDLHCIDIGDMSWQKLGPTGTAPVGCAAHAAVAVGH 278
Cdd:PLN02193  300 NIvdkKWFHCSTPGDSFSIRGGAGLEVVQGKVWVVYGFNGCEV-DDVHYYDPVQDKWTQVETFGVRPSERSVFASAAVGK 378

                         250
                  ....*....|
gi 1958761205 279 HVYVFGGMTA 288
Cdd:PLN02193  379 HIVIFGGEIA 388
PLN02153 PLN02153
epithiospecifier protein
 212-323 1.12e-09

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 59.23  E-value: 1.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761205 212 GSPPSPRHGHAMVAAGTKLFIHGG-LAGDRFFD-DLHCIDIGDMSWQKLGPTGTAP-VGCAAHAAVAVGHHVYVFGGMTA 288
Cdd:PLN02153   17 GKGPGPRCSHGIAVVGDKLYSFGGeLKPNEHIDkDLYVFDFNTHTWSIAPANGDVPrISCLGVRMVAVGTKLYIFGGRDE 96

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1958761205 289 TGALNTMYKYHTEKQHWTILqfdTSL-----PPGRLDHSM 323
Cdd:PLN02153   97 KREFSDFYSYDTVKNEWTFL---TKLdeeggPEARTFHSM 133
PLN02153 PLN02153
epithiospecifier protein
 50-285 1.34e-09

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 59.23  E-value: 1.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761205  50 GDKPCPRVGHSCSYfppVGEaekgKVFIVGGA-NPNQSF-SDVHTMDLGTHRWDTATREGLLPRYEHASFLPSCSPHSIW 127
Cdd:PLN02153   17 GKGPGPRCSHGIAV---VGD----KLYSFGGElKPNEHIdKDLYVFDFNTHTWSIAPANGDVPRISCLGVRMVAVGTKLY 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761205 128 VFGGADQSGNRNCLQVMNPEARTWS----TPEVTGcpPSPRTFHtSSAAIGNHLYVFGGGERGAQPVQDVKLHVFDANTL 203
Cdd:PLN02153   90 IFGGRDEKREFSDFYSYDTVKNEWTfltkLDEEGG--PEARTFH-SMASDENHVYVFGGVSKGGLMKTPERFRTIEAYNI 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761205 204 T---WAQPETHGSPPSPRHGHAMVAAGTKLFIHGGLA--------GDRFFDDLHCIDIGDMSWQKLGPTGTAPVGCAAHA 272
Cdd:PLN02153  167 AdgkWVQLPDPGENFEKRGGAGFAVVQGKIWVVYGFAtsilpggkSDYESNAVQFFDPASGKWTEVETTGAKPSARSVFA 246

                         250
                  ....*....|...
gi 1958761205 273 AVAVGHHVYVFGG 285
Cdd:PLN02153  247 HAVVGKYIIIFGG 259
Kelch_3 pfam13415
Galactose oxidase, central domain;
174-226 2.33e-07

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 46.90  E-value: 2.33e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958761205 174 GNHLYVFGGGERGAQPVQDvKLHVFDANTLTWAQPethGSPPSPRHGHAMVAA 226
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLN-DLYVYDLDTNTWTQI---GDLPPPRSGHSATYI 49
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
53-193 1.95e-06

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 49.00  E-value: 1.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761205  53 PCPRVGHSCSYFPpvgeaeKGKVFIVGGANpnqsfsdvhtmdlGTHRWDTATREGLLP--RYEHASFLPScspHSIWVFG 130
Cdd:COG3055   156 PTPRDHLAAAVLP------DGKILVIGGRN-------------GSGFSNTWTTLAPLPtaRAGHAAAVLG---GKILVFG 213

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958761205 131 GadQSGNRNCLQVMNPEARTWSTpevTGCPPSPRTFHTSsAAIGNHLYVFGGGERGAQPVQDV 193
Cdd:COG3055   214 G--ESGFSDEVEAYDPATNTWTA---LGELPTPRHGHAA-VLTDGKVYVIGGETKPGVRTPLV 270
Kelch_6 pfam13964
Kelch motif;
163-218 7.75e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 42.71  E-value: 7.75e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958761205 163 PRTFHtSSAAIGNHLYVFGGGERGAQPVQdvKLHVFDANTLTWaqpETHGSPPSPR 218
Cdd:pfam13964   1 PRTFH-SVVSVGGYIYVFGGYTNASPALN--KLEVYNPLTKSW---EELPPLPTPR 50
PLN02153 PLN02153
epithiospecifier protein
 59-246 8.42e-06

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 47.29  E-value: 8.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761205  59 HSCSYFPPVGEAEK------------GKVFIVGGANPNQSFSDVHTMDLGTHRWDTATREGLLPRYEHASFLPSCSPHS- 125
Cdd:PLN02153   60 HTWSIAPANGDVPRisclgvrmvavgTKLYIFGGRDEKREFSDFYSYDTVKNEWTFLTKLDEEGGPEARTFHSMASDENh 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761205 126 IWVFGGADQSG----------------------------------------------------------------NRNCL 141
Cdd:PLN02153  140 VYVFGGVSKGGlmktperfrtieayniadgkwvqlpdpgenfekrggagfavvqgkiwvvygfatsilpggksdyESNAV 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761205 142 QVMNPEARTWSTPEVTGCPPSPRTFHtSSAAIGNHLYVFGG-------GERGAQPVQDvKLHVFDANTLTWAQPETHGSP 214
Cdd:PLN02153  220 QFFDPASGKWTEVETTGAKPSARSVF-AHAVVGKYIIIFGGevwpdlkGHLGPGTLSN-EGYALDTETLVWEKLGECGEP 297

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1958761205 215 PSPRHGHAMVAA---GTK-LFIHGG-LAGDRFFDDLH 246
Cdd:PLN02153  298 AMPRGWTAYTTAtvyGKNgLLMHGGkLPTNERTDDLY 334
PRK14131 PRK14131
N-acetylneuraminate epimerase;
170-249 1.73e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 43.47  E-value: 1.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761205 170 SAAIGNHLYVFGGGERGA-----QPVQDVklHVFDANTLTWAQPETHgsppSPRH--GHAMVAA-GTKLFIHGGLAG--- 238
Cdd:PRK14131   80 AAFIDGKLYVFGGIGKTNsegspQVFDDV--YKYDPKTNSWQKLDTR----SPVGlaGHVAVSLhNGKAYITGGVNKnif 153

                          90
                  ....*....|.
gi 1958761205 239 DRFFDDLHCID 249
Cdd:PRK14131  154 DGYFEDLAAAG 164
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 217-260 2.13e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 38.75  E-value: 2.13e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1958761205 217 PRHGHAMVAAGTKLFIHGGLAGDRFFDDLHCIDIGDMSWQKLGP 260
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPS 44
Kelch smart00612
Kelch domain;
281-326 4.13e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 37.92  E-value: 4.13e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1958761205  281 YVFGGMTATGALNTMYKYHTEKQHWTILqfdTSLPPGRLDHSMCVI 326
Cdd:smart00612   3 YVVGGFDGGQRLKSVEVYDPETNKWTPL---PSMPTPRSGHGVAVI 45
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 215-246 4.33e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 37.54  E-value: 4.33e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1958761205 215 PSPRHGHAMVAAGTKLFIHGGLAGDR--FFDDLH 246
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGGEgqPSDDVY 34
Kelch_4 pfam13418
Galactose oxidase, central domain;
217-260 1.02e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 36.82  E-value: 1.02e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1958761205 217 PRHGHAMVA-AGTKLFIHGGLAGD-RFFDDLHCIDIGDMSWQKLGP 260
Cdd:pfam13418   1 PRAYHTSTSiPDDTIYLFGGEGEDgTLLSDLWVFDLSTNEWTRLGS 46
PRK14131 PRK14131
N-acetylneuraminate epimerase;
170-267 1.85e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 40.00  E-value: 1.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761205 170 SAAIGNHLYVfGGGERGaqpvqdVKLHVFDANTLTWAQPETHGSPPSPRHGHAMVAAGTKLFIHGGL------AGDRFFD 243
Cdd:PRK14131   34 GAIDNNTVYV-GLGSAG------TSWYKLDLNAPSKGWTKIAAFPGGPREQAVAAFIDGKLYVFGGIgktnseGSPQVFD 106

                          90       100
                  ....*....|....*....|....
gi 1958761205 244 DLHCIDIGDMSWQKLgPTgTAPVG 267
Cdd:PRK14131  107 DVYKYDPKTNSWQKL-DT-RSPVG 128
Kelch_4 pfam13418
Galactose oxidase, central domain;
55-100 2.50e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 35.67  E-value: 2.50e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1958761205  55 PRVGHSCSYFPpvgeaeKGKVFIVGGAN-PNQSFSDVHTMDLGTHRW 100
Cdd:pfam13418   1 PRAYHTSTSIP------DDTIYLFGGEGeDGTLLSDLWVFDLSTNEW 41
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
281-327 2.83e-03

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 39.37  E-value: 2.83e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1958761205 281 YVFGGMTATGALNTMYKYHTEKQHWTILqfdTSLPPGRLDHSMCVIP 327
Cdd:COG3055    26 YVAGGLSGGSASNSFEVYDPATNTWSEL---APLPGPPRHHAAAVAQ 69
Kelch_3 pfam13415
Galactose oxidase, central domain;
124-172 5.02e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 34.96  E-value: 5.02e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958761205 124 HSIWVFGGADQSGNR--NCLQVMNPEARTWSTpevTGCPPSPRTFHTSSAA 172
Cdd:pfam13415   2 DKLYIFGGLGFDGQTrlNDLYVYDLDTNTWTQ---IGDLPPPRSGHSATYI 49
PLN02772 PLN02772
guanylate kinase
 169-224 5.74e-03

guanylate kinase


Pssm-ID: 215414 [Multi-domain]  Cd Length: 398  Bit Score: 38.67  E-value: 5.74e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958761205 169 SSAAIGNHLYVFGGGERGAQPVQDVKLhvFDANTLTWAQPETHGSPPSPRHGHAMV 224
Cdd:PLN02772   29 TSVTIGDKTYVIGGNHEGNTLSIGVQI--LDKITNNWVSPIVLGTGPKPCKGYSAV 82
PHA03098 PHA03098
kelch-like protein; Provisional
 75-307 6.28e-03

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 38.60  E-value: 6.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761205  75 VFIVGGANP-NQSFSDVHTMDLGTHRWdtatreGLLPRYEHASFLPSCS--PHSIWVFGGADQSGNRNCLQVMNPEARTW 151
Cdd:PHA03098  297 IYFIGGMNKnNLSVNSVVSYDTKTKSW------NKVPELIYPRKNPGVTvfNNRIYVIGGIYNSISLNTVESWKPGESKW 370

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761205 152 STPevtgcPP--SPRtFHTSSAAIGNHLYVFGGGERGAQPVQDVKlhVFDANTLTWAqpeTHGSPPSPRHGHAMVAAGTK 229
Cdd:PHA03098  371 REE-----PPliFPR-YNPCVVNVNNLIYVIGGISKNDELLKTVE--CFSLNTNKWS---KGSPLPISHYGGCAIYHDGK 439

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958761205 230 LFIHGGLA---GDRFFDDLHCIDIGDMSWQKLG----PTGTAPVGcaahaavAVGHHVYVFGGMTATGALNTMYKYHTEK 302
Cdd:PHA03098  440 IYVIGGISyidNIKVYNIVESYNPVTNKWTELSslnfPRINASLC-------IFNNKIYVVGGDKYEYYINEIEVYDDKT 512


                  ....*
gi 1958761205 303 QHWTI 307
Cdd:PHA03098  513 NTWTL 517
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 281-308 7.85e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 34.12  E-value: 7.85e-03
                          10        20
                  ....*....|....*....|....*...
gi 1958761205 281 YVFGGMTATGALNTMYKYHTEKQHWTIL 308
Cdd:pfam01344  15 YVIGGFDGNQSLNSVEVYDPETNTWSKL 42
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 55-105 8.63e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 34.23  E-value: 8.63e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958761205  55 PRVGHSCSYfppvgeaEKGKVFIVGGA--NPNQSFSDVHTMDLGTHRWDTATR 105
Cdd:pfam07646   1 PRYPHASSV-------PGGKLYVVGGSdgLGDLSSSDVLVYDPETNVWTEVPR 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH