|
Name |
Accession |
Description |
Interval |
E-value |
| PUFD_like_1 |
cd14260 |
PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger ... |
1669-1782 |
1.05e-65 |
|
PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor-like protein 1 (BCoR-L1) is largely uncharacterized; it contains ankyrin repeats.
Pssm-ID: 271223 Cd Length: 115 Bit Score: 217.79 E-value: 1.05e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1669 EQDDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHLEITTLPKAEFYRQVASSQLLTPAER 1748
Cdd:cd14260 2 EEDDFMFEFSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEIATMPKAEFYRQVLSSQLLTPAER 81
|
90 100 110
....*....|....*....|....*....|....
gi 1958807188 1749 PGSLEDRSPPGSSETVELVQYEPELLRLLGSEVE 1782
Cdd:cd14260 82 PGGLDDRSPQGSSETVELVRYEPELLRLLGSAVE 115
|
|
| PUFD |
pfam16553 |
BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 ... |
1671-1787 |
1.13e-61 |
|
BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 corepressor) that is needed for binding and giving specificity to some of the PCGF proteins, polycomb-group RING finger homologs. PUFD binds to the RAWUL (RING finger- and WD40-associated ubiquitin-like) domain of the particular PCGF PCGF1, pfam16207. Polycomb group proteins form repressive complexes (PRC) that mediate epigenetic modifications of histones. In humans there are many different PCGF homologs whose functions all vary, but the direct binding partner of PCGF1 is BCOR. BCOR has emerged as an important player in development and health.
Pssm-ID: 465171 Cd Length: 114 Bit Score: 206.08 E-value: 1.13e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1671 DDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHLEITTLPKAEFYRQVASSQLLTPAERPG 1750
Cdd:pfam16553 2 DVFEFEFSDKPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSSRIFRARFPHFEVVTIAEAEFYKQVSLSQLLSPPEDLE 81
|
90 100 110
....*....|....*....|....*....|....*..
gi 1958807188 1751 SledrSPPGSSETVELVQYEPELLRLLGSEVEYQSWS 1787
Cdd:pfam16553 82 A----FNPDSKELVELVEFTPELQTLLGSSVEFLHPS 114
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
1499-1615 |
1.36e-27 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 114.67 E-value: 1.36e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1499 NAGETLLQRAARLGYKDVVLYCLQKHSeDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVN 1578
Cdd:COG0666 118 KDGETPLHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAEN 196
|
90 100 110
....*....|....*....|....*....|....*..
gi 1958807188 1579 DNLETIWLLLSYGADPTLATYSGQTAMKLASSDNMKR 1615
Cdd:COG0666 197 GHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLE 233
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
1505-1596 |
1.04e-16 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 76.69 E-value: 1.04e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1505 LQRAARLGYKDVVLYCLQKHSeDVNHRDNAGYTALHEACSRGWTDILNILLQHgANVNCSSQDGTrPVHDAVVNDNLETI 1584
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGA-DANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRT-ALHYAARSGHLEIV 77
|
90
....*....|..
gi 1958807188 1585 WLLLSYGADPTL 1596
Cdd:pfam12796 78 KLLLEKGADINV 89
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
201-636 |
6.17e-14 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 78.06 E-value: 6.17e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 201 APICPPAPGSASGTPSVPDPFQVPLSVPAPVPHSGLVPVQVATSASAPSPPLAPVPALAPAAPSVPTLISDSNPLSVSAS 280
Cdd:PHA03247 2600 APVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSP 2679
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 281 VLVPVPVSAPhsvpvplsaPAPTPLTVSVSAPPlaliQAPVPPSAPTLVLASVPTPvlapmpastppaapappsvpmPTP 360
Cdd:PHA03247 2680 PQRPRRRAAR---------PTVGSLTSLADPPP----PPPTPEPAPHALVSATPLP---------------------PGP 2725
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 361 TPSSGPPSTPTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPAAIPTSAPI-----------PASFSLSRVCFPAAQAPA 429
Cdd:PHA03247 2726 AAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAagpprrltrpaVASLSESRESLPSPWDPA 2805
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 430 MQKVPLSFQPGTVLTPNQPLVYIPPPSCGQPLSVATLPTTLGVSSTLTLPVLPsylqdrclpgvlASPELRSYPYAFSVA 509
Cdd:PHA03247 2806 DPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAP------------GGDVRRRPPSRSPAA 2873
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 510 RPLASDSKLVSlevnRLSCTSPSSSTNSQPAPEGVPGP-----LADTSLTTASAKVLPTSQPLLPAPSGSSVPLHPSKMP 584
Cdd:PHA03247 2874 KPAAPARPPVR----RLARPAVSRSTESFALPPDQPERppqpqAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDP 2949
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 1958807188 585 GGTDQQTEGTSVTFSPLKSPPQLE--REMASPPECSeMPLDLSSKSNRQKLPLP 636
Cdd:PHA03247 2950 AGAGEPSGAVPQPWLGALVPGRVAvpRFRVPQPAPS-REAPASSTPPLTGHSLS 3002
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
1502-1593 |
3.16e-10 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 64.30 E-value: 3.16e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1502 ETLLQRAARLGYKDVVLYCLqKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNL 1581
Cdd:PHA03100 160 KLLIDKGVDINAKNRVNYLL-SYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNK 238
|
90
....*....|..
gi 1958807188 1582 ETIWLLLSYGAD 1593
Cdd:PHA03100 239 EIFKLLLNNGPS 250
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
218-664 |
7.02e-07 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 54.39 E-value: 7.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 218 PDPFQVPLSVPAPVPHSGLVPVQVATSASAPSPPLAPVPALAPAAPSVPTLISDSNPLSV--SASVLVPVPVSAPHSVPV 295
Cdd:pfam03154 171 PPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLiqQTPTLHPQRLPSPHPPLQ 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 296 PLSAPAPtPLTVSVSAPPLALIQAPVPP------SAPTLVLASVPTpvlapMPASTPPAAPAPPSVPMPTPTPSSGPPST 369
Cdd:pfam03154 251 PMTQPPP-PSQVSPQPLPQPSLHGQMPPmphslqTGPSHMQHPVPP-----QPFPLTPQSSQSQVPPGPSPAAPGQSQQR 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 370 PTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPaaiPTSAPIPAsfslsrvcFPAAQA---PAMQKVPLSFQPGTVLtpn 446
Cdd:pfam03154 325 IHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKP---PPTTPIPQ--------LPNPQShkhPPHLSGPSPFQMNSNL--- 390
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 447 qplvyiPPPSCGQPLSvaTLPTTLGVSStlTLPVLPSYLQDRCLPGVLASPelrsypyafsvarPLASDSKLVSLEVNRL 526
Cdd:pfam03154 391 ------PPPPALKPLS--SLSTHHPPSA--HPPPLQLMPQSQQLPPPPAQP-------------PVLTQSQSLPPPAASH 447
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 527 SCTSPSSSTNSQP-------APEGVPGPLADTSLTTASAKVLPTSQPLLPAPSGSSVPLhpskmPGGTDQQTEGTSVTFS 599
Cdd:pfam03154 448 PPTSGLHQVPSQSpfpqhpfVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPV-----PAAVSCPLPPVQIKEE 522
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958807188 600 PLKSPPQLEremaSPPecsempldlssksnrqklPLPNQRKTPPMPVLTPVHTSSKALLSTVLSR 664
Cdd:pfam03154 523 ALDEAEEPE----SPP------------------PPPRSPSPEPTVVNTPSHASQSARFYKHLDR 565
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
1535-1563 |
5.90e-06 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 44.50 E-value: 5.90e-06
10 20
....*....|....*....|....*....
gi 1958807188 1535 GYTALHEACSRGWTDILNILLQHGANVNC 1563
Cdd:smart00248 2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
1494-1593 |
8.20e-04 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 44.23 E-value: 8.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1494 LIVNKNAGETLLQRAARLGYKDVVLYCLQKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHG---ANVNCSSQ--DG 1568
Cdd:cd22192 10 LLQQKRISESPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAApelVNEPMTSDlyQG 89
|
90 100
....*....|....*....|....*
gi 1958807188 1569 TRPVHDAVVNDNLETIWLLLSYGAD 1593
Cdd:cd22192 90 ETALHIAVVNQNLNLVRELIARGAD 114
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PUFD_like_1 |
cd14260 |
PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger ... |
1669-1782 |
1.05e-65 |
|
PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor-like protein 1 (BCoR-L1) is largely uncharacterized; it contains ankyrin repeats.
Pssm-ID: 271223 Cd Length: 115 Bit Score: 217.79 E-value: 1.05e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1669 EQDDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHLEITTLPKAEFYRQVASSQLLTPAER 1748
Cdd:cd14260 2 EEDDFMFEFSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEIATMPKAEFYRQVLSSQLLTPAER 81
|
90 100 110
....*....|....*....|....*....|....
gi 1958807188 1749 PGSLEDRSPPGSSETVELVQYEPELLRLLGSEVE 1782
Cdd:cd14260 82 PGGLDDRSPQGSSETVELVRYEPELLRLLGSAVE 115
|
|
| PUFD |
pfam16553 |
BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 ... |
1671-1787 |
1.13e-61 |
|
BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 corepressor) that is needed for binding and giving specificity to some of the PCGF proteins, polycomb-group RING finger homologs. PUFD binds to the RAWUL (RING finger- and WD40-associated ubiquitin-like) domain of the particular PCGF PCGF1, pfam16207. Polycomb group proteins form repressive complexes (PRC) that mediate epigenetic modifications of histones. In humans there are many different PCGF homologs whose functions all vary, but the direct binding partner of PCGF1 is BCOR. BCOR has emerged as an important player in development and health.
Pssm-ID: 465171 Cd Length: 114 Bit Score: 206.08 E-value: 1.13e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1671 DDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHLEITTLPKAEFYRQVASSQLLTPAERPG 1750
Cdd:pfam16553 2 DVFEFEFSDKPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSSRIFRARFPHFEVVTIAEAEFYKQVSLSQLLSPPEDLE 81
|
90 100 110
....*....|....*....|....*....|....*..
gi 1958807188 1751 SledrSPPGSSETVELVQYEPELLRLLGSEVEYQSWS 1787
Cdd:pfam16553 82 A----FNPDSKELVELVEFTPELQTLLGSSVEFLHPS 114
|
|
| PUFD_like |
cd14259 |
PCGF Ub-like fold discriminator and related domains; The PUFD domain binds the RAWUL (RING ... |
1671-1782 |
2.17e-42 |
|
PCGF Ub-like fold discriminator and related domains; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor (BCOR) is a transcriptional repressor required for germinal center formation and is possibly involved in apoptosis.
Pssm-ID: 271222 Cd Length: 106 Bit Score: 150.54 E-value: 2.17e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1671 DDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHLEITTLPKAEFYRQVASSQLLTPAERPg 1750
Cdd:cd14259 1 DDFEFEFSDEPLPPLYNLRISPNDGPRNWHLLSDVLTRLKLKSRDFLLKQICLELTSIPIEDFLEQASCLQLLCAGEKL- 79
|
90 100 110
....*....|....*....|....*....|..
gi 1958807188 1751 sledrSPPGSSETVELVQYEPELLRLLGSEVE 1782
Cdd:cd14259 80 -----TNNVSSSKVELVEYNDSLRSLLGIEVE 106
|
|
| PUFD |
cd14261 |
PCGF Ub-like fold discriminator of BCOR; The PUFD domain binds the RAWUL (RING finger and ... |
1666-1783 |
7.67e-39 |
|
PCGF Ub-like fold discriminator of BCOR; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor (BCOR) is a transcriptional repressor required for germinal center formation and is possibly involved in apoptosis.
Pssm-ID: 271224 Cd Length: 117 Bit Score: 141.14 E-value: 7.67e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1666 DDSEQDDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHLEITTLPKAEFYRQVASSQLLTP 1745
Cdd:cd14261 1 DDAYSDVFEFEFSDRPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSSRIFRCNFPNVEVVTIAEAEFYRQVSLSQLFSC 80
|
90 100 110
....*....|....*....|....*....|....*...
gi 1958807188 1746 AErpgSLEDRSPPgSSETVELVQYEPELLRLLGSEVEY 1783
Cdd:cd14261 81 PK---DLEAFNPD-SKELLDLVEFTNELQTLLGSSLEW 114
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
1499-1615 |
1.36e-27 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 114.67 E-value: 1.36e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1499 NAGETLLQRAARLGYKDVVLYCLQKHSeDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVN 1578
Cdd:COG0666 118 KDGETPLHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAEN 196
|
90 100 110
....*....|....*....|....*....|....*..
gi 1958807188 1579 DNLETIWLLLSYGADPTLATYSGQTAMKLASSDNMKR 1615
Cdd:COG0666 197 GHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLE 233
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
1494-1612 |
2.35e-25 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 108.12 E-value: 2.35e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1494 LIVNKNAGETLLQRAARLGYKDVVLYCLqKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVH 1573
Cdd:COG0666 80 INAKDDGGNTLLHAAARNGDLEIVKLLL-EAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLH 158
|
90 100 110
....*....|....*....|....*....|....*....
gi 1958807188 1574 DAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASSDN 1612
Cdd:COG0666 159 LAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENG 197
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
1489-1615 |
9.23e-20 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 91.94 E-value: 9.23e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1489 PEARRLIVNKNA--------GETLLQRAARLGYKDVVLYCLqKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGAN 1560
Cdd:COG0666 133 LEIVKLLLEAGAdvnaqdndGNTPLHLAAANGNLEIVKLLL-EAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD 211
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1958807188 1561 VNCSSQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASSDNMKR 1615
Cdd:COG0666 212 VNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAAL 266
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
1494-1612 |
5.85e-17 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 83.46 E-value: 5.85e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1494 LIVNKNAGETLLQRAARLGYKDVVLYCLQKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVH 1573
Cdd:COG0666 46 ALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLH 125
|
90 100 110
....*....|....*....|....*....|....*....
gi 1958807188 1574 DAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASSDN 1612
Cdd:COG0666 126 LAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANG 164
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
1505-1596 |
1.04e-16 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 76.69 E-value: 1.04e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1505 LQRAARLGYKDVVLYCLQKHSeDVNHRDNAGYTALHEACSRGWTDILNILLQHgANVNCSSQDGTrPVHDAVVNDNLETI 1584
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGA-DANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRT-ALHYAARSGHLEIV 77
|
90
....*....|..
gi 1958807188 1585 WLLLSYGADPTL 1596
Cdd:pfam12796 78 KLLLEKGADINV 89
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
201-636 |
6.17e-14 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 78.06 E-value: 6.17e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 201 APICPPAPGSASGTPSVPDPFQVPLSVPAPVPHSGLVPVQVATSASAPSPPLAPVPALAPAAPSVPTLISDSNPLSVSAS 280
Cdd:PHA03247 2600 APVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSP 2679
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 281 VLVPVPVSAPhsvpvplsaPAPTPLTVSVSAPPlaliQAPVPPSAPTLVLASVPTPvlapmpastppaapappsvpmPTP 360
Cdd:PHA03247 2680 PQRPRRRAAR---------PTVGSLTSLADPPP----PPPTPEPAPHALVSATPLP---------------------PGP 2725
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 361 TPSSGPPSTPTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPAAIPTSAPI-----------PASFSLSRVCFPAAQAPA 429
Cdd:PHA03247 2726 AAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAagpprrltrpaVASLSESRESLPSPWDPA 2805
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 430 MQKVPLSFQPGTVLTPNQPLVYIPPPSCGQPLSVATLPTTLGVSSTLTLPVLPsylqdrclpgvlASPELRSYPYAFSVA 509
Cdd:PHA03247 2806 DPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAP------------GGDVRRRPPSRSPAA 2873
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 510 RPLASDSKLVSlevnRLSCTSPSSSTNSQPAPEGVPGP-----LADTSLTTASAKVLPTSQPLLPAPSGSSVPLHPSKMP 584
Cdd:PHA03247 2874 KPAAPARPPVR----RLARPAVSRSTESFALPPDQPERppqpqAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDP 2949
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 1958807188 585 GGTDQQTEGTSVTFSPLKSPPQLE--REMASPPECSeMPLDLSSKSNRQKLPLP 636
Cdd:PHA03247 2950 AGAGEPSGAVPQPWLGALVPGRVAvpRFRVPQPAPS-REAPASSTPPLTGHSLS 3002
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
66-544 |
7.81e-12 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 71.12 E-value: 7.81e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 66 GSGSNARGTNPDGSTTEKLGHRSEDQPDDPQakmdyvgntaeaeGLLVPLSSPGDSLKLPTPDGTEASHSRANCSWTPLS 145
Cdd:PHA03247 2579 EPAVTSRARRPDAPPQSARPRAPVDDRGDPR-------------GPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPT 2645
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 146 TQMSKQVDCSPAGvkaldSRHSVGEKNTFILATLGTGVPVEGTLPlvttnfsqlpaPICPPAPGSASGTPSVPDPFQVPL 225
Cdd:PHA03247 2646 VPPPERPRDDPAP-----GRVSRPRRARRLGRAAQASSPPQRPRR-----------RAARPTVGSLTSLADPPPPPPTPE 2709
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 226 SVPAP-VPHSGLVPVQVATSASAPSPPlapvpalapaapsvptliSDSNPLSVSASVLVPVPVSAPHSVPVPLSAPAPTP 304
Cdd:PHA03247 2710 PAPHAlVSATPLPPGPAAARQASPALP------------------AAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP 2771
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 305 LTVSVSAPPLALIQAPVPPSAPTLvlASVPTPvlapmpastpPAAPAPPSVPMPTPTPSSGPPSTPTLIPAFAPTPVPAP 384
Cdd:PHA03247 2772 PAAPAAGPPRRLTRPAVASLSESR--ESLPSP----------WDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAP 2839
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 385 TPAPIFTPAPTPM--------------PAATPAAIPTSAPIP-----ASFSLSRVCFPAAQAPAMQKVPLSFQPGTVLTP 445
Cdd:PHA03247 2840 PPPPGPPPPSLPLggsvapggdvrrrpPSRSPAAKPAAPARPpvrrlARPAVSRSTESFALPPDQPERPPQPQAPPPPQP 2919
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 446 N-----QPLVYIPPPSCGQPLSVATlPTTLGVSSTLTLPVLPSYLQDRCLPGVLASPELRSYPYAFSVARPLASDSKLVS 520
Cdd:PHA03247 2920 QpqpppPPQPQPPPPPPPRPQPPLA-PTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTG 2998
|
490 500
....*....|....*....|....
gi 1958807188 521 LEVNRLSCTSPSSSTNSQPAPEGV 544
Cdd:PHA03247 2999 HSLSRVSSWASSLALHEETDPPPV 3022
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
1499-1605 |
1.23e-11 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 67.67 E-value: 1.23e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1499 NAGETLLQRAARLGYKDVVLYcLQKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVN 1578
Cdd:COG0666 184 NDGETPLHLAAENGHLEIVKL-LLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAA 262
|
90 100
....*....|....*....|....*..
gi 1958807188 1579 DNLETIWLLLSYGADPTLATYSGQTAM 1605
Cdd:COG0666 263 GAALIVKLLLLALLLLAAALLDLLTLL 289
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
1502-1593 |
3.16e-10 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 64.30 E-value: 3.16e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1502 ETLLQRAARLGYKDVVLYCLqKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNL 1581
Cdd:PHA03100 160 KLLIDKGVDINAKNRVNYLL-SYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNK 238
|
90
....*....|..
gi 1958807188 1582 ETIWLLLSYGAD 1593
Cdd:PHA03100 239 EIFKLLLNNGPS 250
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
1496-1562 |
7.61e-10 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 57.43 E-value: 7.61e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958807188 1496 VNKNAGETLLQRAARLGYKDVVLYCLQKhsEDVNHRDNaGYTALHEACSRGWTDILNILLQHGANVN 1562
Cdd:pfam12796 25 LQDKNGRTALHLAAKNGHLEIVKLLLEH--ADVNLKDN-GRTALHYAARSGHLEIVKLLLEKGADIN 88
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
1539-1624 |
4.81e-09 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 55.12 E-value: 4.81e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1539 LHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNLETIWLLLSYGAdpTLATYSGQTAMKLASSDNMK---R 1615
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAARSGHLeivK 78
|
....*....
gi 1958807188 1616 FLSDHLSDL 1624
Cdd:pfam12796 79 LLLEKGADI 87
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
1489-1622 |
8.14e-09 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 60.06 E-value: 8.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1489 PEARRLIVNKNA--------GETLLQRAA--RLGYKDVVLYCLQKHSeDVNHRDNAGYTALHEA--CSRGWTDILNILLQ 1556
Cdd:PHA03100 86 KEIVKLLLEYGAnvnapdnnGITPLLYAIskKSNSYSIVEYLLDNGA-NVNIKNSDGENLLHLYleSNKIDLKILKLLID 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1557 HGANVN-CSSQD---------------GTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASSDNMKRFLSDH 1620
Cdd:PHA03100 165 KGVDINaKNRVNyllsygvpinikdvyGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLL 244
|
..
gi 1958807188 1621 LS 1622
Cdd:PHA03100 245 LN 246
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
1470-1593 |
2.23e-07 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 55.84 E-value: 2.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1470 YRSAGSEETSESPTARQIPPEARRLIVNKNA----GETLLQRAARLGYKDVVLYCLQKHSEDVNHRDNAGYTALHEACSR 1545
Cdd:PHA02876 272 CKNTPLHHASQAPSLSRLVPKLLERGADVNAknikGETPLYLMAKNGYDTENIRTLIMLGADVNAADRLYITPLHQASTL 351
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1958807188 1546 G-WTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNLETIWLLLSYGAD 1593
Cdd:PHA02876 352 DrNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGAD 400
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
1490-1612 |
2.67e-07 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 54.19 E-value: 2.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1490 EARRLIVNKNAGETLLQRAARLGYKDVVLYCLQKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGT 1569
Cdd:COG0666 9 LLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGN 88
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1958807188 1570 RPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASSDN 1612
Cdd:COG0666 89 TLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNG 131
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
1535-1587 |
3.64e-07 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 48.42 E-value: 3.64e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1958807188 1535 GYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNLETI-WLL 1587
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLkLLL 54
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
1553-1637 |
4.08e-07 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 54.90 E-value: 4.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1553 ILLQHGANVNCSSQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASSDNMKRFLSDHLSDLQGRAEGDP 1632
Cdd:PTZ00322 100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFELGA 179
|
....*
gi 1958807188 1633 RASWD 1637
Cdd:PTZ00322 180 NAKPD 184
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
218-664 |
7.02e-07 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 54.39 E-value: 7.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 218 PDPFQVPLSVPAPVPHSGLVPVQVATSASAPSPPLAPVPALAPAAPSVPTLISDSNPLSV--SASVLVPVPVSAPHSVPV 295
Cdd:pfam03154 171 PPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLiqQTPTLHPQRLPSPHPPLQ 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 296 PLSAPAPtPLTVSVSAPPLALIQAPVPP------SAPTLVLASVPTpvlapMPASTPPAAPAPPSVPMPTPTPSSGPPST 369
Cdd:pfam03154 251 PMTQPPP-PSQVSPQPLPQPSLHGQMPPmphslqTGPSHMQHPVPP-----QPFPLTPQSSQSQVPPGPSPAAPGQSQQR 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 370 PTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPaaiPTSAPIPAsfslsrvcFPAAQA---PAMQKVPLSFQPGTVLtpn 446
Cdd:pfam03154 325 IHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKP---PPTTPIPQ--------LPNPQShkhPPHLSGPSPFQMNSNL--- 390
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 447 qplvyiPPPSCGQPLSvaTLPTTLGVSStlTLPVLPSYLQDRCLPGVLASPelrsypyafsvarPLASDSKLVSLEVNRL 526
Cdd:pfam03154 391 ------PPPPALKPLS--SLSTHHPPSA--HPPPLQLMPQSQQLPPPPAQP-------------PVLTQSQSLPPPAASH 447
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 527 SCTSPSSSTNSQP-------APEGVPGPLADTSLTTASAKVLPTSQPLLPAPSGSSVPLhpskmPGGTDQQTEGTSVTFS 599
Cdd:pfam03154 448 PPTSGLHQVPSQSpfpqhpfVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPV-----PAAVSCPLPPVQIKEE 522
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958807188 600 PLKSPPQLEremaSPPecsempldlssksnrqklPLPNQRKTPPMPVLTPVHTSSKALLSTVLSR 664
Cdd:pfam03154 523 ALDEAEEPE----SPP------------------PPPRSPSPEPTVVNTPSHASQSARFYKHLDR 565
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
1521-1604 |
1.31e-06 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 53.10 E-value: 1.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1521 LQKHSEDVNHRDNAGYTALHeACSRGW---TDILNILLQHGANVNCSSQDGTRPVHDAVVNDN--LETIWLLLSYGADPT 1595
Cdd:PHA03095 103 LIKAGADVNAKDKVGRTPLH-VYLSGFninPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNanVELLRLLIDAGADVY 181
|
....*....
gi 1958807188 1596 LATYSGQTA 1604
Cdd:PHA03095 182 AVDDRFRSL 190
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
1503-1555 |
1.82e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 46.50 E-value: 1.82e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1958807188 1503 TLLQRAARLGYKDVVLYCLQkHSEDVNHRDNAGYTALHEACSRGWTDILNILL 1555
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLE-KGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
1527-1605 |
3.63e-06 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 51.50 E-value: 3.63e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958807188 1527 DVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAM 1605
Cdd:PHA02874 116 DVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPL 194
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
1513-1608 |
3.88e-06 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 51.42 E-value: 3.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1513 YKDVVLYCLQKHSEDVNHRDNAGYTALHEACSRGWT-DILNILLQHGANVNC-SSQDGTRPVHDAVVNDnlETIWLLLSY 1590
Cdd:PHA02878 212 YNKPIVHILLENGASTDARDKCGNTPLHISVGYCKDyDILKLLLEHGVDVNAkSYILGLTALHSSIKSE--RKLKLLLEY 289
|
90
....*....|....*...
gi 1958807188 1591 GADPTLATYSGQTAMKLA 1608
Cdd:PHA02878 290 GADINSLNSYKLTPLSSA 307
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
1535-1563 |
5.90e-06 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 44.50 E-value: 5.90e-06
10 20
....*....|....*....|....*....
gi 1958807188 1535 GYTALHEACSRGWTDILNILLQHGANVNC 1563
Cdd:smart00248 2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
208-419 |
1.17e-05 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 50.26 E-value: 1.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 208 PGSASGTPSVPDPFQVPLSVPAPVPHSGLVPVQVATSASAPSPPLAPVPALAPAAPSVPTLIS---DSNPLSVSASVLVP 284
Cdd:PRK12323 365 PGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSpapEALAAARQASARGP 444
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 285 VPVSAPHSVPVPLSAPAPTPLTVSVSAPPLALIQAPVPPsaptlvlASVPTPVLAPMPASTPPAAPAPPSVPMPTPTPSS 364
Cdd:PRK12323 445 GGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARA-------APAAAPAPADDDPPPWEELPPEFASPAPAQPDAA 517
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1958807188 365 GPPSTPTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPAAIPTSAPIPASFSLSR 419
Cdd:PRK12323 518 PAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASG 572
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
1501-1617 |
1.44e-05 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 50.25 E-value: 1.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1501 GETLLQRAARLGYKDVVLYCLqKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNcsSQDGTRPVHDAVVNDN 1580
Cdd:PLN03192 558 GRTPLHIAASKGYEDCVLVLL-KHACNVHIRDANGNTALWNAISAKHHKIFRILYHFASISD--PHAAGDLLCTAAKRND 634
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1958807188 1581 LETIWLLLSYGADPTLATYSGQTAMKLASSD---NMKRFL 1617
Cdd:PLN03192 635 LTAMKELLKQGLNVDSEDHQGATALQVAMAEdhvDMVRLL 674
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
1536-1624 |
1.74e-05 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 49.28 E-value: 1.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1536 YTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVH-----DAVVNDNLETIWLLLSYGADPTLATYSGQT-----AM 1605
Cdd:PHA03100 36 VLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHylsniKYNLTDVKEIVKLLLEYGANVNAPDNNGITpllyaIS 115
|
90
....*....|....*....
gi 1958807188 1606 KLASSDNMKRFLSDHLSDL 1624
Cdd:PHA03100 116 KKSNSYSIVEYLLDNGANV 134
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
1521-1610 |
2.02e-05 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 49.11 E-value: 2.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1521 LQKHSEDVNHRD-NAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATY 1599
Cdd:PHA02878 153 LLSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDK 232
|
90
....*....|.
gi 1958807188 1600 SGQTAMKLASS 1610
Cdd:PHA02878 233 CGNTPLHISVG 243
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
1527-1593 |
2.03e-05 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 49.25 E-value: 2.03e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958807188 1527 DVNHRDNAGYTALHEACSRGW---TDILNILLQHGANVNCSSQDGTRPVHDAVVNDN-LETIWLLLSYGAD 1593
Cdd:PHA03095 39 DVNFRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGAD 109
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
215-649 |
2.14e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.94 E-value: 2.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 215 PSVPDPFQVPLSVPAPVPHSGLVP-VQVATSASAPSPPLAPVPALAPAAPSVPTLISDSnplsvSASVLVPVPVSAPHSV 293
Cdd:PHA03247 2489 PFAAGAAPDPGGGGPPDPDAPPAPsRLAPAILPDEPVGEPVHPRMLTWIRGLEELASDD-----AGDPPPPLPPAAPPAA 2563
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 294 P---VPLSAPAPTPLTVSV-------SAPPL-ALIQAPV-PPSAPTLVLASVPTPVLAPMPASTPPAAPAPPSVPMPTPT 361
Cdd:PHA03247 2564 PdrsVPPPRPAPRPSEPAVtsrarrpDAPPQsARPRAPVdDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPP 2643
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 362 PSSGPPSTPTLIPAfaptPVPAPTPAPIFTPAPTPMPAATPAAIPTSAPIPASFSLSRVCFPAAQAPAMQKVPLSFQPGT 441
Cdd:PHA03247 2644 PTVPPPERPRDDPA----PGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSAT 2719
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 442 VLTPNQPLVYIPPPScgQPLSVATLPTTLGvsstltlPVLPSYLQDRCLPGVLASPELRSYPyafsVARPLASDSKLVSL 521
Cdd:PHA03247 2720 PLPPGPAAARQASPA--LPAAPAPPAVPAG-------PATPGGPARPARPPTTAGPPAPAPP----AAPAAGPPRRLTRP 2786
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 522 EVNRLSCTSPSSSTNSQPAPEGVPGPLADTSLTTASA---------KVLPTSQPLLPAPSGSSVPLHPSKMPGG--TDQQ 590
Cdd:PHA03247 2787 AVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASpagplppptSAQPTAPPPPPGPPPPSLPLGGSVAPGGdvRRRP 2866
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 591 TEGTSVTFSPLKSPPQLEREMASPPECSEMPLDLSSKS-NRQKLPLPNQRKTPPMPVLTP 649
Cdd:PHA03247 2867 PSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQpERPPQPQAPPPPQPQPQPPPP 2926
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
1521-1573 |
3.30e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 43.10 E-value: 3.30e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1958807188 1521 LQKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVH 1573
Cdd:pfam13857 2 LEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
1535-1563 |
4.13e-05 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 42.28 E-value: 4.13e-05
10 20 30
....*....|....*....|....*....|
gi 1958807188 1535 GYTALHEACSR-GWTDILNILLQHGANVNC 1563
Cdd:pfam00023 2 GNTPLHLAAGRrGNLEIVKLLLSKGADVNA 31
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
1527-1590 |
1.22e-04 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 46.82 E-value: 1.22e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958807188 1527 DVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNLETIWLLLSY 1590
Cdd:PTZ00322 107 DPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
|
|
| Ank_3 |
pfam13606 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
1535-1563 |
1.46e-04 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.
Pssm-ID: 463933 [Multi-domain] Cd Length: 30 Bit Score: 40.32 E-value: 1.46e-04
10 20
....*....|....*....|....*....
gi 1958807188 1535 GYTALHEACSRGWTDILNILLQHGANVNC 1563
Cdd:pfam13606 2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
1521-1584 |
2.94e-04 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 45.82 E-value: 2.94e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958807188 1521 LQKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNLETI 1584
Cdd:PHA02876 164 LLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTI 227
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
1495-1562 |
3.32e-04 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 45.04 E-value: 3.32e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958807188 1495 IVNKNA-GETLLQRAARLGYKDVVLYCLQKhSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVN 1562
Cdd:PHA03100 185 INIKDVyGFTPLHYAVYNNNPEFVKYLLDL-GANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
1521-1617 |
4.15e-04 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 45.24 E-value: 4.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1521 LQKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNLETIWLLLSYGA--DPTLAT 1598
Cdd:PLN03192 544 LLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFASisDPHAAG 623
|
90
....*....|....*....
gi 1958807188 1599 YSGQTAMKLASSDNMKRFL 1617
Cdd:PLN03192 624 DLLCTAAKRNDLTAMKELL 642
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
1502-1608 |
5.25e-04 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 44.57 E-value: 5.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1502 ETLLQRAARLGYKDVVlYCLQKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNL 1581
Cdd:PHA02874 125 KTFLHYAIKKGDLESI-KMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDY 203
|
90 100
....*....|....*....|....*..
gi 1958807188 1582 ETIWLLLSYGADPTLATYSGQTAMKLA 1608
Cdd:PHA02874 204 ACIKLLIDHGNHIMNKCKNGFTPLHNA 230
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
1513-1595 |
7.27e-04 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 44.25 E-value: 7.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1513 YKDVVLyCLQKHSEDVNHRDNAGYTALH-EACSRGWTDILNILLQHGANVNCSSQDGTRPVHD--AVVNDNLETIWLLLS 1589
Cdd:PHA03095 62 VKDIVR-LLLEAGADVNAPERCGFTPLHlYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVylSGFNINPKVIRLLLR 140
|
....*.
gi 1958807188 1590 YGADPT 1595
Cdd:PHA03095 141 KGADVN 146
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
1521-1622 |
7.99e-04 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 44.25 E-value: 7.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1521 LQKHSEDVNHRDNAGYTALHEA---CSRGWTDILNiLLQHGANVNCSSQDGTRPVHDAVVNDNLETIWLLLSYGADPTLA 1597
Cdd:PHA03095 208 LIRAGCDPAATDMLGNTPLHSMatgSSCKRSLVLP-LLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAV 286
|
90 100
....*....|....*....|....*....
gi 1958807188 1598 TYSGQTAMKLASSDN----MKRFLSDHLS 1622
Cdd:PHA03095 287 SSDGNTPLSLMVRNNngraVRAALAKNPS 315
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
1494-1593 |
8.20e-04 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 44.23 E-value: 8.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1494 LIVNKNAGETLLQRAARLGYKDVVLYCLQKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHG---ANVNCSSQ--DG 1568
Cdd:cd22192 10 LLQQKRISESPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAApelVNEPMTSDlyQG 89
|
90 100
....*....|....*....|....*
gi 1958807188 1569 TRPVHDAVVNDNLETIWLLLSYGAD 1593
Cdd:cd22192 90 ETALHIAVVNQNLNLVRELIARGAD 114
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
1521-1598 |
1.09e-03 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 43.44 E-value: 1.09e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958807188 1521 LQKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDG-TRPVHDAVVNDNLETIWLLLSYGADPTLAT 1598
Cdd:PHA02875 154 LIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGcVAALCYAIENNKIDIVRLFIKRGADCNIMF 232
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
1518-1610 |
1.16e-03 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 43.44 E-value: 1.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 1518 LYCLQKHSEDVNHRDnaGYTALHEACSRGWTDILNILLQHGANVNCSSQDGTRPVHDAVVNDNLETIWLLLSYGADPTLA 1597
Cdd:PHA02875 87 LLDLGKFADDVFYKD--GMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIE 164
|
90
....*....|...
gi 1958807188 1598 TYSGQTAMKLASS 1610
Cdd:PHA02875 165 DCCGCTPLIIAMA 177
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
1495-1567 |
2.18e-03 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 42.93 E-value: 2.18e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958807188 1495 IVNKNAGETLLQRAARLGykDV-VLYCLQKHSEDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQD 1567
Cdd:PLN03192 616 ISDPHAAGDLLCTAAKRN--DLtAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTD 687
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
1554-1608 |
2.92e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 37.71 E-value: 2.92e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1958807188 1554 LLQHG-ANVNCSSQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLA 1608
Cdd:pfam13857 1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| PHA03269 |
PHA03269 |
envelope glycoprotein C; Provisional |
175-336 |
3.77e-03 |
|
envelope glycoprotein C; Provisional
Pssm-ID: 165527 [Multi-domain] Cd Length: 566 Bit Score: 42.02 E-value: 3.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 175 ILATLGTGVPvegTLPLVTTNFSQLPapicPPAPGSASGTPSVPDPFQVPLSVPAPVPHSGLVPVQVATSASAPSpplap 254
Cdd:PHA03269 18 IIANLNTNIP---IPELHTSAATQKP----DPAPAPHQAASRAPDPAVAPTSAASRKPDLAQAPTPAASEKFDPA----- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 255 vpalapaapsvptlisdsnPLSVSASVLVPVPVSAPHSVpvplSAPAPTPLTVSVSAPPlaliQAPVPPSAPTLVLASVP 334
Cdd:PHA03269 86 -------------------PAPHQAASRAPDPAVAPQLA----AAPKPDAAEAFTSAAQ----AHEAPADAGTSAASKKP 138
|
..
gi 1958807188 335 TP 336
Cdd:PHA03269 139 DP 140
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
311-569 |
7.75e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 41.01 E-value: 7.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 311 APPLALIQAPVPPSAPTLVLASVPTPVLAPMPASTPPAAPAPPSVPMPTPTPSSGPPSTPTLIPAFAPTPVPaptpapif 390
Cdd:PRK12323 372 AGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARG-------- 443
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 391 tPAPTPMPAATPAAIPTSAPIPASFSLSRVCFPAAQAPAMQKVPLSFQPGTVLTPnqPLVYIPPpscgqplsvatlpttl 470
Cdd:PRK12323 444 -PGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPP--PWEELPP---------------- 504
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958807188 471 gvsstlTLPVLPSYLQDRCLPGVLASPELRSYPYAFSVARPlasdsklvSLEVNRLSCTSPSSSTNSQPAPEGVPGPLAD 550
Cdd:PRK12323 505 ------EFASPAPAQPDAAPAGWVAESIPDPATADPDDAFE--------TLAPAPAAAPAPRAAAATEPVVAPRPPRASA 570
|
250
....*....|....*....
gi 1958807188 551 TSLTTASAKVLPTSQPLLP 569
Cdd:PRK12323 571 SGLPDMFDGDWPALAARLP 589
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
1550-1612 |
8.94e-03 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 40.82 E-value: 8.94e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958807188 1550 ILNILLQHGANVNCSSQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASSDN 1612
Cdd:PHA02876 160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSK 222
|
|
| PHA02795 |
PHA02795 |
ankyrin-like protein; Provisional |
1526-1568 |
9.42e-03 |
|
ankyrin-like protein; Provisional
Pssm-ID: 165157 [Multi-domain] Cd Length: 437 Bit Score: 40.36 E-value: 9.42e-03
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 1958807188 1526 EDVNHRDNAGYTALHEACSRGWTDILNILLQHGANVNCSSQDG 1568
Cdd:PHA02795 212 EDINQLDAGGRTLLYRAIYAGYIDLVSWLLENGANVNAVMSNG 254
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