RNAP_Rpb7_N_like: This conserved domain represents the N-terminal ribonucleoprotein (RNP) domain of the Rpb7 subunit of eukaryotic RNA polymerase (RNAP) II and its homologs, Rpa43 of eukaryotic RNAP I, Rpc25 of eukaryotic RNAP III, and RpoE (subunit E) of archaeal RNAP. These proteins have, in addition to their N-terminal RNP domain, a C-terminal oligonucleotide-binding (OB) domain. Each of these subunits heterodimerizes with another RNAP subunit (Rpb7 to Rpb4, Rpc25 to Rpc17, RpoE to RpoF, and Rpa43 to Rpa14). The heterodimer is thought to tether the RNAP to a given promoter via its interactions with a promoter-bound transcription factor.The heterodimer is also thought to bind and position nascent RNA as it exits the polymerase complex.

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                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955881902   9 ANMVVYVHPSKSKKVSQAVLRVLGAMLLKFDEKFEGVLLAYeakiiDKIaKILSGVH-------PYFGVTIKAKLLLFSP 81
Cdd:cd04328    14 VSLYVSLAPKYLGNPLTGIKAQLLNPLLKYSPKLKGVVLAY-----SNI-KLLEGELakivddsPFIFVWISADFLVFRP 87

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gi 1955881902  82 K 82
Cdd:cd04328    88 K 88

RNAP_I_Rpa43_N: Rpa43, N-terminal ribonucleoprotein (RNP) domain. Rpa43 is a subunit of eukaryotic RNA polymerase (RNAP) I that is homologous to Rpb7 of eukaryotic RNAP II, Rpc25 of eukaryotic RNP III, and RpoE of archaeal RNAP. Rpa43 has two domains, an N-terminal RNP domain and a C-terminal oligonucleotide-binding (OB) domain. Rpa43 heterodimerizes with Rpa14 and this heterodimer has genetic and biochemical characteristics similar to those of the Rpb7/Rpb4 heterodimer of RNAP II. In addition, the Rpa43/Rpa14 heterodimer binds single-stranded RNA, as is the case for the Rpb7/Rpb4 and the archaeal E/F complexes. The position of Rpa43/Rpa14 in the three-dimensional structure of RNAP I is similar to that of Rpb4/Rpb7, which forms an upstream interface between the C-terminal domain of Rpb1 and the transcription factor IIB (TFIIB), recruiting pol II to the pol II promoter. Rpb43 binds Rrn3, an rDNA-specific transcription factor, functionally equivalent to TFIIB, involved in recruiting RNAP I to the pol I promoter.

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                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955881902   9 ANMVVYVHPSKSKKVSQAVLRVLGAMLLKFDEKFEGVLLAYeakiiDKIaKILSGVH-------PYFGVTIKAKLLLFSP 81
Cdd:cd04328    14 VSLYVSLAPKYLGNPLTGIKAQLLNPLLKYSPKLKGVVLAY-----SNI-KLLEGELakivddsPFIFVWISADFLVFRP 87

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gi 1955881902  82 K 82
Cdd:cd04328    88 K 88

RNAP_I_Rpa43_N: Rpa43, N-terminal ribonucleoprotein (RNP) domain. Rpa43 is a subunit of eukaryotic RNA polymerase (RNAP) I that is homologous to Rpb7 of eukaryotic RNAP II, Rpc25 of eukaryotic RNP III, and RpoE of archaeal RNAP. Rpa43 has two domains, an N-terminal RNP domain and a C-terminal oligonucleotide-binding (OB) domain. Rpa43 heterodimerizes with Rpa14 and this heterodimer has genetic and biochemical characteristics similar to those of the Rpb7/Rpb4 heterodimer of RNAP II. In addition, the Rpa43/Rpa14 heterodimer binds single-stranded RNA, as is the case for the Rpb7/Rpb4 and the archaeal E/F complexes. The position of Rpa43/Rpa14 in the three-dimensional structure of RNAP I is similar to that of Rpb4/Rpb7, which forms an upstream interface between the C-terminal domain of Rpb1 and the transcription factor IIB (TFIIB), recruiting pol II to the pol II promoter. Rpb43 binds Rrn3, an rDNA-specific transcription factor, functionally equivalent to TFIIB, involved in recruiting RNAP I to the pol I promoter.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955881902   9 ANMVVYVHPSKSKKVSQAVLRVLGAMLLKFDEKFEGVLLAYeakiiDKIaKILSGVH-------PYFGVTIKAKLLLFSP 81
Cdd:cd04328    14 VSLYVSLAPKYLGNPLTGIKAQLLNPLLKYSPKLKGVVLAY-----SNI-KLLEGELakivddsPFIFVWISADFLVFRP 87

                  .
gi 1955881902  82 K 82
Cdd:cd04328    88 K 88