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Conserved domains on  [gi|1955856264|ref|XP_038886208|]
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probable aquaporin PIP2-5 [Benincasa hispida]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 11088534)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  11473620|8849412|11964478
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 51-288 2.95e-93

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


:

Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 275.74  E-value: 2.95e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264  51 EIRKWSFYRALIAEFMATLLFLYVTVLTVIGYKsetdgmgkKNVDSCGEVGILGIAWAFGGMIFVLVYCTAGISGGHINP 130
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVK--------KLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNP 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264 131 AVTFGLLLGRKVSLVRAVMYMVAQCLGAISGVGLVKAFQKAhFQKYGGGANGLSDDYTASVGLAAEIVGTFVLVYTVFSA 210
Cdd:pfam00230  73 AVTLALLVGRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVG-LQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFAT 151

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1955856264 211 TDPKRNARDSHVpvlAPLPIGFAVFMVHLATIPITGTGINPARSLGSAVIFNDqkaWNNHWIFWVGPFIGAAIAAFYH 288
Cdd:pfam00230 152 TDDRRNGSLGTV---APLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWK---WDDHWVYWVGPFIGAALGALVY 223
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 51-288 2.95e-93

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 275.74  E-value: 2.95e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264  51 EIRKWSFYRALIAEFMATLLFLYVTVLTVIGYKsetdgmgkKNVDSCGEVGILGIAWAFGGMIFVLVYCTAGISGGHINP 130
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVK--------KLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNP 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264 131 AVTFGLLLGRKVSLVRAVMYMVAQCLGAISGVGLVKAFQKAhFQKYGGGANGLSDDYTASVGLAAEIVGTFVLVYTVFSA 210
Cdd:pfam00230  73 AVTLALLVGRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVG-LQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFAT 151

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1955856264 211 TDPKRNARDSHVpvlAPLPIGFAVFMVHLATIPITGTGINPARSLGSAVIFNDqkaWNNHWIFWVGPFIGAAIAAFYH 288
Cdd:pfam00230 152 TDDRRNGSLGTV---APLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWK---WDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 59-291 4.09e-75

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 229.83  E-value: 4.09e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264  59 RALIAEFMATLLFLYVTVLTVIGYKSETDGMGkknvdscgevGILGIAWAFGGMIFVLVYCTAGISGGHINPAVTFGLLL 138
Cdd:cd00333     1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGGASG----------GLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAV 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264 139 GRKVSLVRAVMYMVAQCLGAISGVGLVKAFQKAHFQKYGGGANGLSDDYTASV--------GLAAEIVGTFVLVYTVFSA 210
Cdd:cd00333    71 GGRFPLIRVIPYIIAQLLGAILGAALLYGLYYGLYLEFLGANNIVAGIFGTYPspgvsngnAFFVEFIGTFILVLVVFAT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264 211 TDPKRNArdsHVPVLAPLPIGFAVFMVHLATIPITGTGINPARSLGSAVIFNDQKAWNNHWIFWVGPFIGAAIAAFYHQF 290
Cdd:cd00333   151 TDDPNGP---PPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLARHWHYFWVYWVGPLIGAIAGALVYDY 227


                  .
gi 1955856264 291 I 291
Cdd:cd00333   228 V 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 63-288 2.76e-64

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 201.76  E-value: 2.76e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264  63 AEFMATLLFLYVTVLTVIGYKsetdgmGKKNVDSCGEVGILGIAWAFGGMIFVLVYCTAGISGGHINPAVTFGLLLGRKV 142
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVN------VAGAYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRF 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264 143 SLVRAVMYMVAQCLGAISGVGLVKAFQKAHFQKYGGGANGLSDDYTASVGLAAEIVGTFVLVYTVFSATDpKRNARDSHv 222
Cdd:TIGR00861  75 PLKRVPVYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASAGVSSGQAFFVEFIGTAILVLVIFATTD-DRNRVPRG- 152

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1955856264 223 pVLAPLPIGFAVFMVHLATIPITGTGINPARSLGSAVIFNdQKAWNNHWIFWVGPFIGAAIAAFYH 288
Cdd:TIGR00861 153 -GFAPLAIGLLVFLIHLSMGPYTGTGMNPARSLGPALFAG-LAGWGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 56-293 3.95e-57

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 183.79  E-value: 3.95e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264  56 SFYRALIAEFMAT--LLFLYVTVLTVIGyksetdgmgkknvDSCGEVGILGIAWAFGGMIFVLVYCTAGISGGHINPAVT 133
Cdd:COG0580     1 SLMKRLLAEFLGTfiLVLLGCGVVAVLA-------------GTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVT 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264 134 FGLLLGRKVSLVRAVMYMVAQCLGAISGVGLVKAFQKAHFQKYGGG-------ANGLSDDYTASVGLAAEIVGTFVLVYT 206
Cdd:COG0580    68 LALAVAGRFPWKDVLPYIIAQLLGAFLGAALVYLIYGGHFDATEDGgaklgvfATSPAIGYSLGAAFLTEIIGTFVLVFV 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264 207 VFSATDPKRNARdshvpVLAPLPIGFAVFMVHLATIPITGTGINPARSLGSAV---IFNDQKAWNNHWIFWVGPFIGAAI 283
Cdd:COG0580   148 ILGITDKRAAPG-----GLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLfhaLGKGGSDWGYLWVPIVAPILGAAL 222

                         250
                  ....*....|
gi 1955856264 284 AAFYHQFILR 293
Cdd:COG0580   223 AALLYRALFG 232
PLN00027 PLN00027
aquaporin TIP; Provisional
 59-291 5.31e-39

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 137.61  E-value: 5.31e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264  59 RALIAEFMATLLFLYVTVLTVIGYKSETDGmgkknvDSCGEVGILGIAWAFGGMIFVLVYCTAGISGGHINPAVTFGLLL 138
Cdd:PLN00027   21 KAALAEFISTLIFVFAGEGSGMAFNKLTDN------GSTTPAGLVAAALAHAFALFVAVSVGANISGGHVNPAVTFGAFI 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264 139 GRKVSLVRAVMYMVAQCLGAISGVGLVKaFQKAHFQKyggGANGLSDDYTASVGLAAEIVGTFVLVYTVF-SATDPKRna 217
Cdd:PLN00027   95 GGNITLLRGILYWIAQLLGSVVACLLLK-FSTGGLET---SAFSLSSGVGVWNAFVFEIVMTFGLVYTVYaTAVDPKK-- 168

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1955856264 218 rdSHVPVLAPLPIGFAVFMVHLATIPITGTGINPARSLGSAVIFNDqkaWNNHWIFWVGPFIGAAIAAFYHQFI 291
Cdd:PLN00027  169 --GDLGIIAPIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWT---WTNHWVYWAGPLIGGGIAGLVYELI 237
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 51-288 2.95e-93

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 275.74  E-value: 2.95e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264  51 EIRKWSFYRALIAEFMATLLFLYVTVLTVIGYKsetdgmgkKNVDSCGEVGILGIAWAFGGMIFVLVYCTAGISGGHINP 130
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVK--------KLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNP 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264 131 AVTFGLLLGRKVSLVRAVMYMVAQCLGAISGVGLVKAFQKAhFQKYGGGANGLSDDYTASVGLAAEIVGTFVLVYTVFSA 210
Cdd:pfam00230  73 AVTLALLVGRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVG-LQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFAT 151

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1955856264 211 TDPKRNARDSHVpvlAPLPIGFAVFMVHLATIPITGTGINPARSLGSAVIFNDqkaWNNHWIFWVGPFIGAAIAAFYH 288
Cdd:pfam00230 152 TDDRRNGSLGTV---APLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWK---WDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 59-291 4.09e-75

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 229.83  E-value: 4.09e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264  59 RALIAEFMATLLFLYVTVLTVIGYKSETDGMGkknvdscgevGILGIAWAFGGMIFVLVYCTAGISGGHINPAVTFGLLL 138
Cdd:cd00333     1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGGASG----------GLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAV 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264 139 GRKVSLVRAVMYMVAQCLGAISGVGLVKAFQKAHFQKYGGGANGLSDDYTASV--------GLAAEIVGTFVLVYTVFSA 210
Cdd:cd00333    71 GGRFPLIRVIPYIIAQLLGAILGAALLYGLYYGLYLEFLGANNIVAGIFGTYPspgvsngnAFFVEFIGTFILVLVVFAT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264 211 TDPKRNArdsHVPVLAPLPIGFAVFMVHLATIPITGTGINPARSLGSAVIFNDQKAWNNHWIFWVGPFIGAAIAAFYHQF 290
Cdd:cd00333   151 TDDPNGP---PPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLARHWHYFWVYWVGPLIGAIAGALVYDY 227


                  .
gi 1955856264 291 I 291
Cdd:cd00333   228 V 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 63-288 2.76e-64

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 201.76  E-value: 2.76e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264  63 AEFMATLLFLYVTVLTVIGYKsetdgmGKKNVDSCGEVGILGIAWAFGGMIFVLVYCTAGISGGHINPAVTFGLLLGRKV 142
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVN------VAGAYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRF 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264 143 SLVRAVMYMVAQCLGAISGVGLVKAFQKAHFQKYGGGANGLSDDYTASVGLAAEIVGTFVLVYTVFSATDpKRNARDSHv 222
Cdd:TIGR00861  75 PLKRVPVYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASAGVSSGQAFFVEFIGTAILVLVIFATTD-DRNRVPRG- 152

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1955856264 223 pVLAPLPIGFAVFMVHLATIPITGTGINPARSLGSAVIFNdQKAWNNHWIFWVGPFIGAAIAAFYH 288
Cdd:TIGR00861 153 -GFAPLAIGLLVFLIHLSMGPYTGTGMNPARSLGPALFAG-LAGWGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 56-293 3.95e-57

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 183.79  E-value: 3.95e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264  56 SFYRALIAEFMAT--LLFLYVTVLTVIGyksetdgmgkknvDSCGEVGILGIAWAFGGMIFVLVYCTAGISGGHINPAVT 133
Cdd:COG0580     1 SLMKRLLAEFLGTfiLVLLGCGVVAVLA-------------GTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVT 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264 134 FGLLLGRKVSLVRAVMYMVAQCLGAISGVGLVKAFQKAHFQKYGGG-------ANGLSDDYTASVGLAAEIVGTFVLVYT 206
Cdd:COG0580    68 LALAVAGRFPWKDVLPYIIAQLLGAFLGAALVYLIYGGHFDATEDGgaklgvfATSPAIGYSLGAAFLTEIIGTFVLVFV 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264 207 VFSATDPKRNARdshvpVLAPLPIGFAVFMVHLATIPITGTGINPARSLGSAV---IFNDQKAWNNHWIFWVGPFIGAAI 283
Cdd:COG0580   148 ILGITDKRAAPG-----GLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLfhaLGKGGSDWGYLWVPIVAPILGAAL 222

                         250
                  ....*....|
gi 1955856264 284 AAFYHQFILR 293
Cdd:COG0580   223 AALLYRALFG 232
PLN00027 PLN00027
aquaporin TIP; Provisional
 59-291 5.31e-39

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 137.61  E-value: 5.31e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264  59 RALIAEFMATLLFLYVTVLTVIGYKSETDGmgkknvDSCGEVGILGIAWAFGGMIFVLVYCTAGISGGHINPAVTFGLLL 138
Cdd:PLN00027   21 KAALAEFISTLIFVFAGEGSGMAFNKLTDN------GSTTPAGLVAAALAHAFALFVAVSVGANISGGHVNPAVTFGAFI 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264 139 GRKVSLVRAVMYMVAQCLGAISGVGLVKaFQKAHFQKyggGANGLSDDYTASVGLAAEIVGTFVLVYTVF-SATDPKRna 217
Cdd:PLN00027   95 GGNITLLRGILYWIAQLLGSVVACLLLK-FSTGGLET---SAFSLSSGVGVWNAFVFEIVMTFGLVYTVYaTAVDPKK-- 168

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1955856264 218 rdSHVPVLAPLPIGFAVFMVHLATIPITGTGINPARSLGSAVIFNDqkaWNNHWIFWVGPFIGAAIAAFYHQFI 291
Cdd:PLN00027  169 --GDLGIIAPIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWT---WTNHWVYWAGPLIGGGIAGLVYELI 237
PLN00166 PLN00166
aquaporin TIP2; Provisional
 59-288 6.38e-39

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 137.38  E-value: 6.38e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264  59 RALIAEFMATLLFLYVTVLTVIGY-KSETDGMgkknVDSCGEVGIlGIAWAFGgmIFVLVYCTAGISGGHINPAVTFGLL 137
Cdd:PLN00166   19 KAYLSEFIATLLFVFAGVGSAIAFaKLTSDAA----LDPAGLVAV-AVAHAFA--LFVGVSIAANISGGHLNPAVTLGLA 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264 138 LGRKVSLVRAVMYMVAQCLGAISGVGLVKAFQKAHFQKYGGGANGLSddytASVGLAAEIVGTFVLVYTVF-SATDPKRN 216
Cdd:PLN00166   92 IGGNITIITGFFYWIAQCLGSIVACLLLVFVTNGESVPTHGVAAGLG----AIEGVVMEIVVTFALVYTVYaTAADPKKG 167

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1955856264 217 ArdshVPVLAPLPIGFAVFMVHLATIPITGTGINPARSLGSAVIFNDqkaWNNHWIFWVGPFIGAAIAAFYH 288
Cdd:PLN00166  168 S----LGTIAPIAIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGD---FSQIWIYWVGPLVGGALAGLIY 232
PRK05420 PRK05420
aquaporin Z; Provisional
 100-296 1.02e-35

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 128.55  E-value: 1.02e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264 100 VGILGIAWAFGGMIFVLVYCTAGISGGHINPAVTFGLLLGRKVSLVRAVMYMVAQCLGAISGVGL--VKAFQKAHFQKYG 177
Cdd:PRK05420   34 IGFLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFPAKELVPYIIAQVVGGIAAAAVlyLIASGKAGFDLAG 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264 178 GG--ANGLSD----DYTASVGLAAEIVGTFVLVYTVFSATdpkrnarDSHVPV-LAPLPIGFAVFMVHLATIPITGTGIN 250
Cdd:PRK05420  114 SGfaSNGYGEhspgGYSLLAALVCEVVLTAFFLLVILGAT-------DKRAPAgFAPIAIGLALTLIHLISIPVTNTSVN 186

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1955856264 251 PARSLGSAvIFNDQKAWNNHWIFWVGPFIGAAIAAFYHQFILRAGA 296
Cdd:PRK05420  187 PARSTGVA-LFVGGWALEQLWLFWVAPIVGAIIGGLIYRLLLEKDD 231
PLN00167 PLN00167
aquaporin TIP5; Provisional
 59-286 5.24e-27

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 106.14  E-value: 5.24e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264  59 RALIAEFMATLLFlyvtVLTVIGYKSETDGMGKKNVDSCGEVGILGIAWAFGgmIFVLVYCTAGISGGHINPAVTFGLLL 138
Cdd:PLN00167   23 RSYLAEFISTFFF----VFAAVGSAMSSRKLMPDAASDPSSLLIVAIANAFA--LSSAVYIAANISGGHVNPAVTFGMAV 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264 139 GRKVSLVRAVMYMVAQCLGAISGVGLVK-AFQKAHFQKYggganGLSDDYTASVGLAAEIVGTFVLVYTVFSATDPKRna 217
Cdd:PLN00167   97 GGHISVPTAMFYWISQMLASVMACLFLKvTTVGQHVPTY-----KIAEEMTGFGASVLEGVLTFGLVYTVYAAGDPRR-- 169

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1955856264 218 rdSHVPVLAPLPIGFAVFMVHLATIPITGTGINPARSLGSAVIFNDQKawnNHWIFWVGPFIGAAIAAF 286
Cdd:PLN00167  170 --GLLGAIGPLAIGLVAGANVLAAGPFSGGSMNPACAFGSAVVAGSFK---NQAVYWVGPLLGGAVAGL 233
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 43-292 5.86e-20

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 87.87  E-value: 5.86e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264  43 PVPLIDGEEIRKW-SFYRALIAEFMATLLFLYV---TVLTVIGYKSETDGMGkknvdscgevgiLGIAWAFGgmIFVLVY 118
Cdd:PTZ00016   34 PPGGQNFWAPREYrPNVREYVAEFLGTFVLLFFgegVVATTHTVGNNGDYLA------------ITIGWGLG--VTFGLL 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264 119 CTAGISGGHINPAVTFGLLLGRKVSLVRAVMYMVAQCLGAISGVGLVKAFQKAHFQKYGGG--ANGLSDDYTASV----- 191
Cdd:PTZ00016  100 VSAGISGGHLNPAVTLGNAVFGKFPWKKLPGYFVAQLLGAFVGAACVYGLYYGFFKDHGIPelPWETMANGFAGVfatyp 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264 192 ------GLAAEIVGTFVLVYTVFSATDPKRNARDSHVPVlaplPIGFAVFMVHLATIPITGTGINPARSLG----SAVIF 261
Cdd:PTZ00016  180 regnfyAIFSELILTAILLLVILAITDPNNCPAFNYLPV----AVGLLVFVIGISFGGNTGYALNPARDLGprlfSAILW 255

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1955856264 262 NDQKAWNNHWIFW---VGPFIGAAIAAFYHQFIL 292
Cdd:PTZ00016  256 GSEVFTKDNYYFWvplVAPFVGAVLGMFLYDKFI 289
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 93-291 4.19e-18

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 82.65  E-value: 4.19e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264  93 NVDSCGEVGILGIAWAFGGMIFVLVYCTAGISGGHINPAVTFGLLLGRKVSLVRAVMYMVAQCLGAISGVG----LVKAF 168
Cdd:PLN00182   66 NVLYGGTITFPGICVTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFPWYQVPLYIGAQLTGSLLASLtlrlMFNVT 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264 169 QKAHFQKYGGGANGLSddytasvgLAAEIVGTFVLVYTVFSATDPKRNARDshvpvLAPLPIGFAVFMVHLATIPITGTG 248
Cdd:PLN00182  146 PEAFFGTTPTDSSGQA--------LVAEIIISFLLMFVISGVATDSRAVGE-----LAGIAVGMTIILNVFVAGPISGAS 212

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1955856264 249 INPARSLGSAVIFNDQKAWnnhWIFWVGPFIGAAIAAFYHQFI 291
Cdd:PLN00182  213 MNPARSLGPAIVMGRYKGI---WVYIVGPFVGIIAGGFVYNLI 252
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 59-293 2.67e-17

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 79.90  E-value: 2.67e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264  59 RALIAEFMATLLFLYvtvlTVIGYKSETDGMGkknvdscGEVGILGIAWAFGGMIFVLVYCTAGISGGHINPAVTFGLLL 138
Cdd:PLN00183   46 RMVLAEMVGTFILMF----CVCGIIASTQLSG-------GEVGLLEYAATAGLTVVVVVFSIGSISGAHVNPSVTIAFAT 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264 139 GRKVSLVRAVMYMVAQCLGAISGVGLVKAFqkahfqkYGGGANGLSDDYTASVGLA--AEIVGTFVLVYTVFSATDPKRN 216
Cdd:PLN00183  115 FGHFPWSKVPLYITAQTVGSVLATYVGVSV-------YGVKADLMTTKPAQGCSSAfwVEFIATFIVMFLAASLTSQPQS 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264 217 ARDshvpvLAPLPIGFAVFMVHLATIPITGTGINPARSLGSAVIfndqkAWN--NHWIFWVGPFIGAAIAAF-YHQFILR 293
Cdd:PLN00183  188 LGH-----LSGFVIGIAIGLAVLITGPVSGGSMNPARSLGPAIV-----SWDfkDIWIYITAPTIGAVAGALmFHLLRLR 257
PLN00184 PLN00184
aquaporin NIP1; Provisional
 36-291 4.77e-16

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 76.98  E-value: 4.77e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264  36 KDYYDPPPVPLIDGEEIRKWSFYRALIAEFMATLLFLYVTVLTVIgyksetdgmgkKNVDSCGEVGILGIAWAFGGMIFV 115
Cdd:PLN00184   32 EAIHNPKPLKKQDSLLSVSVPFLQKLIAEVLGTYFLVFTGCASVV-----------VNMQNDNVVTLPGIAIVWGLTIMV 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264 116 LVYCTAGISGGHINPAVTFGLLLGRKVSLVRAVMYMVAQCLGAIsgvgLVKAFQKAHFQKYGGGANGLSDDYTASV---- 191
Cdd:PLN00184  101 LIYSLGHISGAHINPAVTIAFASCGRFPLKQVPAYVISQVIGST----LAAATLRLLFGLDHDVCSGKHDVFIGSSpvgs 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264 192 ---GLAAEIVGTFVLVYTVFS-ATDpkrnarDSHVPVLAPLPIGFAVFMVHLATIPITGTGINPARSLGSAVIFNdqkAW 267
Cdd:PLN00184  177 dlqAFVMEFIVTFYLMFIISGvATD------NRAIGELAGLAIGSTVLLNVLIAAPVSSASMNPGRSLGPAMVYG---CY 247

                         250       260
                  ....*....|....*....|....
gi 1955856264 268 NNHWIFWVGPFIGAAIAAFYHQFI 291
Cdd:PLN00184  248 KGIWIYIVAPTLGAIAGAWVYNTV 271
PLN00026 PLN00026
aquaporin NIP; Provisional
 41-285 2.80e-14

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 71.82  E-value: 2.80e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264  41 PPPVplidgeeirkwSFYRALIAEFMATLLFLYVTVLTVIgyksetdgmgkKNVDSCGEVGILGIAWAFGGMIFVLVYCT 120
Cdd:PLN00026   65 PPDV-----------SLTRKLGAEFVGTFILIFAATAGPI-----------VNQKYDGAETLIGNAACAGLAVMIVILST 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264 121 AGISGGHINPAVTFGLLLGRKVSLVRAVMYMVAQCLGAISGVGLVKAFqkahFQKYGGGANGLSDDYTASvGLAAEIVGT 200
Cdd:PLN00026  123 GHISGAHLNPSLTIAFAALRHFPWKHVPAYIAAQVSASICASFALKGV----FHPFMSGGVTVPSVSTGQ-AFALEFIIT 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955856264 201 FVLVYTVFS-ATDPKRnardshVPVLAPLPIGFAVFMVHLATIPITGTGINPARSLGSAVIFNDQKAWnnhWIFWVGPFI 279
Cdd:PLN00026  198 FNLLFVVTAvATDTRA------VGELAGIAVGATVMLNILVAGPSTGGSMNPVRTLGPAVAAGNYRAI---WIYLVAPTL 268


                  ....*.
gi 1955856264 280 GAAIAA 285
Cdd:PLN00026  269 GALAGA 274
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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