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Conserved domains on  [gi|1955849637|ref|XP_038882885|]
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heavy metal-associated isoprenylated plant protein 7-like [Benincasa hispida]

Protein Classification

heavy-metal-associated domain-containing protein( domain architecture ID 10086609)

heavy-metal-associated domain-containing protein may function as a heavy metal transporter and/or detoxification protein; such as heavy metal-associated isoprenylated plant proteins

Gene Ontology:  GO:0046872
PubMed:  12443926|8905098

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HMA cd00371
Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid ...
 56-117 6.79e-10

Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.


:

Pssm-ID: 238219 [Multi-domain]  Cd Length: 63  Bit Score: 54.15  E-value: 6.79e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1955849637  56 VLKVD-MHCEACARKVARALKGFQGVENVTTDSRTGKVVVKGKGADPSKVCERLQKKSGRKVE 117
Cdd:cd00371     1 ELSVEgMTCAGCVSKIEKALEKLPGVESVEVDLETGKATVEYDPEVSPEELLEAIEDAGYKAR 63
HMA pfam00403
Heavy-metal-associated domain;
158-204 4.79e-06

Heavy-metal-associated domain;


:

Pssm-ID: 459804 [Multi-domain]  Cd Length: 58  Bit Score: 42.99  E-value: 4.79e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1955849637 158 VQMHCEACAQVLRKRIRKFKGVESVETELANNQVIVKGIMDPTRLID 204
Cdd:pfam00403   5 SGMHCGGCAAKVEKALSELPGVLSVSVDLATKTVTVTGDAESTKLEK 51
 
Name Accession Description Interval E-value
HMA cd00371
Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid ...
 56-117 6.79e-10

Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.


Pssm-ID: 238219 [Multi-domain]  Cd Length: 63  Bit Score: 54.15  E-value: 6.79e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1955849637  56 VLKVD-MHCEACARKVARALKGFQGVENVTTDSRTGKVVVKGKGADPSKVCERLQKKSGRKVE 117
Cdd:cd00371     1 ELSVEgMTCAGCVSKIEKALEKLPGVESVEVDLETGKATVEYDPEVSPEELLEAIEDAGYKAR 63
HMA pfam00403
Heavy-metal-associated domain;
55-110 1.89e-07

Heavy-metal-associated domain;


Pssm-ID: 459804 [Multi-domain]  Cd Length: 58  Bit Score: 47.23  E-value: 1.89e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1955849637  55 IVLKVDMHCEACARKVARALKGFQGVENVTTDSRTGKVVVKGKGAD--PSKVCERLQK 110
Cdd:pfam00403   1 TFRVSGMHCGGCAAKVEKALSELPGVLSVSVDLATKTVTVTGDAEStkLEKLVEAIEK 58
CopZ COG2608
Copper chaperone CopZ [Inorganic ion transport and metabolism];
54-110 7.03e-07

Copper chaperone CopZ [Inorganic ion transport and metabolism];


Pssm-ID: 442020 [Multi-domain]  Cd Length: 71  Bit Score: 46.05  E-value: 7.03e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955849637  54 EIVLKVD-MHCEACARKVARALKGFQGVENVTTDSRTGKVVVKGKG--ADPSKVCERLQK 110
Cdd:COG2608     3 TVTLKVEgMTCGHCVARVEKALKALDGVASVEVDLATGTATVTYDPekVSLEDIKAAIEE 62
HMA pfam00403
Heavy-metal-associated domain;
158-204 4.79e-06

Heavy-metal-associated domain;


Pssm-ID: 459804 [Multi-domain]  Cd Length: 58  Bit Score: 42.99  E-value: 4.79e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1955849637 158 VQMHCEACAQVLRKRIRKFKGVESVETELANNQVIVKGIMDPTRLID 204
Cdd:pfam00403   5 SGMHCGGCAAKVEKALSELPGVLSVSVDLATKTVTVTGDAESTKLEK 51
HMA cd00371
Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid ...
 155-208 4.84e-06

Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.


Pssm-ID: 238219 [Multi-domain]  Cd Length: 63  Bit Score: 43.36  E-value: 4.84e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1955849637 155 VLNVQ-MHCEACAQVLRKRIRKFKGVESVETELANNQVIVKG--IMDPTRLIDHVSK 208
Cdd:cd00371     1 ELSVEgMTCAGCVSKIEKALEKLPGVESVEVDLETGKATVEYdpEVSPEELLEAIED 57
PLN02957 PLN02957
copper, zinc superoxide dismutase
 59-119 2.52e-05

copper, zinc superoxide dismutase


Pssm-ID: 215516 [Multi-domain]  Cd Length: 238  Bit Score: 44.74  E-value: 2.52e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1955849637  59 VDMHCEACARKVARALKGFQGVENVTTDSRTGkvVVKGKGADPSKVCERLQKKSGRKVELI 119
Cdd:PLN02957   12 VDMKCEGCVAAVKNKLETLEGVKAVEVDLSNQ--VVRVLGSSPVKAMTAALEQTGRKARLI 70
CopZ COG2608
Copper chaperone CopZ [Inorganic ion transport and metabolism];
153-195 1.32e-04

Copper chaperone CopZ [Inorganic ion transport and metabolism];


Pssm-ID: 442020 [Multi-domain]  Cd Length: 71  Bit Score: 39.50  E-value: 1.32e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1955849637 153 TVVLNVQ-MHCEACAQVLRKRIRKFKGVESVETELANNQVIVKG 195
Cdd:COG2608     3 TVTLKVEgMTCGHCVARVEKALKALDGVASVEVDLATGTATVTY 46
 
Name Accession Description Interval E-value
HMA cd00371
Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid ...
 56-117 6.79e-10

Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.


Pssm-ID: 238219 [Multi-domain]  Cd Length: 63  Bit Score: 54.15  E-value: 6.79e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1955849637  56 VLKVD-MHCEACARKVARALKGFQGVENVTTDSRTGKVVVKGKGADPSKVCERLQKKSGRKVE 117
Cdd:cd00371     1 ELSVEgMTCAGCVSKIEKALEKLPGVESVEVDLETGKATVEYDPEVSPEELLEAIEDAGYKAR 63
HMA pfam00403
Heavy-metal-associated domain;
55-110 1.89e-07

Heavy-metal-associated domain;


Pssm-ID: 459804 [Multi-domain]  Cd Length: 58  Bit Score: 47.23  E-value: 1.89e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1955849637  55 IVLKVDMHCEACARKVARALKGFQGVENVTTDSRTGKVVVKGKGAD--PSKVCERLQK 110
Cdd:pfam00403   1 TFRVSGMHCGGCAAKVEKALSELPGVLSVSVDLATKTVTVTGDAEStkLEKLVEAIEK 58
CopZ COG2608
Copper chaperone CopZ [Inorganic ion transport and metabolism];
54-110 7.03e-07

Copper chaperone CopZ [Inorganic ion transport and metabolism];


Pssm-ID: 442020 [Multi-domain]  Cd Length: 71  Bit Score: 46.05  E-value: 7.03e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955849637  54 EIVLKVD-MHCEACARKVARALKGFQGVENVTTDSRTGKVVVKGKG--ADPSKVCERLQK 110
Cdd:COG2608     3 TVTLKVEgMTCGHCVARVEKALKALDGVASVEVDLATGTATVTYDPekVSLEDIKAAIEE 62
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
53-132 4.66e-06

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 47.83  E-value: 4.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955849637  53 SEIVLKVD-MHCEACARKVARALKGFQGVENVTTDSRTGKVVV--KGKGADPSKVCERLQkKSGRKVELISPLPKPPEEQ 129
Cdd:COG2217     1 ERVRLRIEgMTCAACAWLIEKALRKLPGVLSARVNLATERARVeyDPGKVSLEELIAAVE-KAGYEAEPADADAAAEEAR 79


                  ...
gi 1955849637 130 PKE 132
Cdd:COG2217    80 EKE 82
HMA pfam00403
Heavy-metal-associated domain;
158-204 4.79e-06

Heavy-metal-associated domain;


Pssm-ID: 459804 [Multi-domain]  Cd Length: 58  Bit Score: 42.99  E-value: 4.79e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1955849637 158 VQMHCEACAQVLRKRIRKFKGVESVETELANNQVIVKGIMDPTRLID 204
Cdd:pfam00403   5 SGMHCGGCAAKVEKALSELPGVLSVSVDLATKTVTVTGDAESTKLEK 51
HMA cd00371
Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid ...
 155-208 4.84e-06

Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.


Pssm-ID: 238219 [Multi-domain]  Cd Length: 63  Bit Score: 43.36  E-value: 4.84e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1955849637 155 VLNVQ-MHCEACAQVLRKRIRKFKGVESVETELANNQVIVKG--IMDPTRLIDHVSK 208
Cdd:cd00371     1 ELSVEgMTCAGCVSKIEKALEKLPGVESVEVDLETGKATVEYdpEVSPEELLEAIED 57
PLN02957 PLN02957
copper, zinc superoxide dismutase
 59-119 2.52e-05

copper, zinc superoxide dismutase


Pssm-ID: 215516 [Multi-domain]  Cd Length: 238  Bit Score: 44.74  E-value: 2.52e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1955849637  59 VDMHCEACARKVARALKGFQGVENVTTDSRTGkvVVKGKGADPSKVCERLQKKSGRKVELI 119
Cdd:PLN02957   12 VDMKCEGCVAAVKNKLETLEGVKAVEVDLSNQ--VVRVLGSSPVKAMTAALEQTGRKARLI 70
CopZ COG2608
Copper chaperone CopZ [Inorganic ion transport and metabolism];
153-195 1.32e-04

Copper chaperone CopZ [Inorganic ion transport and metabolism];


Pssm-ID: 442020 [Multi-domain]  Cd Length: 71  Bit Score: 39.50  E-value: 1.32e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1955849637 153 TVVLNVQ-MHCEACAQVLRKRIRKFKGVESVETELANNQVIVKG 195
Cdd:COG2608     3 TVTLKVEgMTCGHCVARVEKALKALDGVASVEVDLATGTATVTY 46
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
153-208 2.29e-04

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 42.44  E-value: 2.29e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955849637 153 TVVLNVQ-MHCEACAQVLRKRIRKFKGVESVETELANNQVIV---KGIMDPTRLIDHVSK 208
Cdd:COG2217     2 RVRLRIEgMTCAACAWLIEKALRKLPGVLSARVNLATERARVeydPGKVSLEELIAAVEK 61
zntA PRK11033
zinc/cadmium/mercury/lead-transporting ATPase; Provisional
 60-132 1.24e-03

zinc/cadmium/mercury/lead-transporting ATPase; Provisional


Pssm-ID: 236827 [Multi-domain]  Cd Length: 741  Bit Score: 40.36  E-value: 1.24e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1955849637  60 DMHCEACARKVARALKGFQGVENVTTDSRTGKVVVKGKgADPSKVCERLQKKSG-RKVELISPLPKPPEEQPKE 132
Cdd:PRK11033   61 GMDCPSCARKVENAVRQLAGVNQVQVLFATEKLVVDAD-NDIRAQVESAVQKAGfSLRDEQAAAAAPESRLKSE 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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