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Conserved domains on  [gi|1955843287|ref|XP_038879616|]
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myb-related protein 306-like [Benincasa hispida]

Protein Classification

SANT/Myb-like DNA-binding domain-containing protein( domain architecture ID 1000535)

SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain-containing protein may be involved in the regulation of gene expression

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03212 super family cl31985
Transcription repressor MYB5; Provisional
 4-162 2.30e-53

Transcription repressor MYB5; Provisional


The actual alignment was detected with superfamily member PLN03212:

Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 174.50  E-value: 2.30e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955843287   4 SPCCTQtFGIKKGPWTPEEDIILVSYIHQHGPGNWRSVPNNTGLLRCSKSCRLRWTNYLRPGIKRGHFTDHEDNMIVHLQ 83
Cdd:PLN03212   15 TPCCTK-MGMKRGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLLRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLH 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955843287  84 ALLGNRWAAIASYLPQRTDNDIKNYWNTHLKKK-LKLGFDDQNNGFSKGQWERRLQTDIQTAKQELRQALSLTTTDQNSI 162
Cdd:PLN03212   94 RLLGNRWSLIAGRIPGRTDNEIKNYWNTHLRKKlLRQGIDPQTHKPLDANNIHKPEEEVSGGQKYPIEPISSSHTDDTTV 173
 
Name Accession Description Interval E-value
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 4-162 2.30e-53

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 174.50  E-value: 2.30e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955843287   4 SPCCTQtFGIKKGPWTPEEDIILVSYIHQHGPGNWRSVPNNTGLLRCSKSCRLRWTNYLRPGIKRGHFTDHEDNMIVHLQ 83
Cdd:PLN03212   15 TPCCTK-MGMKRGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLLRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLH 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955843287  84 ALLGNRWAAIASYLPQRTDNDIKNYWNTHLKKK-LKLGFDDQNNGFSKGQWERRLQTDIQTAKQELRQALSLTTTDQNSI 162
Cdd:PLN03212   94 RLLGNRWSLIAGRIPGRTDNEIKNYWNTHLRKKlLRQGIDPQTHKPLDANNIHKPEEEVSGGQKYPIEPISSSHTDDTTV 173
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 13-118 1.47e-16

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 79.45  E-value: 1.47e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955843287  13 IKKGPWTPEEDIILVSYIHQHGPGNWRSVPNNTGLlRCSKSCRLRWTNYLRPGIKRGHFTDHEDNMIVHLQALLGNRWAA 92
Cdd:COG5147    18 RKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLIS-STGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWST 96

                          90       100
                  ....*....|....*....|....*.
gi 1955843287  93 IASYLPQRTDNDIKNYWNTHLKKKLK 118
Cdd:COG5147    97 IADYKDRRTAQQCVERYVNTLEDLSS 122
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 68-113 2.55e-12

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 60.21  E-value: 2.55e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1955843287  68 RGHFTDHEDNMIVHLQALLGNRWAAIASYLPQRTDNDIKNYWNTHL 113
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
15-64 7.96e-12

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 59.16  E-value: 7.96e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1955843287   15 KGPWTPEEDIILVSYIHQHGPGNWRSVPNNTGlLRCSKSCRLRWTNYLRP 64
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELP-GRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 17-62 3.70e-11

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 57.20  E-value: 3.70e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1955843287  17 PWTPEEDIILVSYIHQHGPGNWRSVPNNTGlLRCSKSCRLRWTNYL 62
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGKNNWEKIAKELP-GRTPKQCRERWRNLL 45
 
Name Accession Description Interval E-value
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 4-162 2.30e-53

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 174.50  E-value: 2.30e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955843287   4 SPCCTQtFGIKKGPWTPEEDIILVSYIHQHGPGNWRSVPNNTGLLRCSKSCRLRWTNYLRPGIKRGHFTDHEDNMIVHLQ 83
Cdd:PLN03212   15 TPCCTK-MGMKRGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLLRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLH 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955843287  84 ALLGNRWAAIASYLPQRTDNDIKNYWNTHLKKK-LKLGFDDQNNGFSKGQWERRLQTDIQTAKQELRQALSLTTTDQNSI 162
Cdd:PLN03212   94 RLLGNRWSLIAGRIPGRTDNEIKNYWNTHLRKKlLRQGIDPQTHKPLDANNIHKPEEEVSGGQKYPIEPISSSHTDDTTV 173
PLN03091 PLN03091
hypothetical protein; Provisional
 1-219 4.86e-48

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 166.69  E-value: 4.86e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955843287   1 MGRSPCCTQTfGIKKGPWTPEEDIILVSYIHQHGPGNWRSVPNNTGLLRCSKSCRLRWTNYLRPGIKRGHFTDHEDNMIV 80
Cdd:PLN03091    1 MGRHSCCYKQ-KLRKGLWSPEEDEKLLRHITKYGHGCWSSVPKQAGLQRCGKSCRLRWINYLRPDLKRGTFSQQEENLII 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955843287  81 HLQALLGNRWAAIASYLPQRTDNDIKNYWNTHLKKKLKLGFDDQNNGFSKGQWERRLQTDIQTAKQElRQALSLTTTDQN 160
Cdd:PLN03091   80 ELHAVLGNRWSQIAAQLPGRTDNEIKNLWNSCLKKKLRQRGIDPNTHKPLSEVENGEDKNPPTDDKS-DKASSVVSNELN 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1955843287 161 SIQSNqNLNPPPFSANSSISQLLLPNQQHASSSSTTTYVSNAENIARLLENWTKNSPNK 219
Cdd:PLN03091  159 LLKAD-NSKPLAALQEKRSSSISPAGYQLEVESSSSSKINNSNNNNHSNSNLMTPTPNK 216
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 13-118 1.47e-16

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 79.45  E-value: 1.47e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955843287  13 IKKGPWTPEEDIILVSYIHQHGPGNWRSVPNNTGLlRCSKSCRLRWTNYLRPGIKRGHFTDHEDNMIVHLQALLGNRWAA 92
Cdd:COG5147    18 RKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLIS-STGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWST 96

                          90       100
                  ....*....|....*....|....*.
gi 1955843287  93 IASYLPQRTDNDIKNYWNTHLKKKLK 118
Cdd:COG5147    97 IADYKDRRTAQQCVERYVNTLEDLSS 122
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 68-113 2.55e-12

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 60.21  E-value: 2.55e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1955843287  68 RGHFTDHEDNMIVHLQALLGNRWAAIASYLPQRTDNDIKNYWNTHL 113
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 15-62 3.63e-12

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 59.82  E-value: 3.63e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1955843287  15 KGPWTPEEDIILVSYIHQHGpGNWRSVPNNTGlLRCSKSCRLRWTNYL 62
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLG-NRWKKIAKLLP-GRTDNQCKNRWQNYL 46
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
15-64 7.96e-12

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 59.16  E-value: 7.96e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1955843287   15 KGPWTPEEDIILVSYIHQHGPGNWRSVPNNTGlLRCSKSCRLRWTNYLRP 64
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELP-GRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 17-62 3.70e-11

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 57.20  E-value: 3.70e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1955843287  17 PWTPEEDIILVSYIHQHGPGNWRSVPNNTGlLRCSKSCRLRWTNYL 62
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGKNNWEKIAKELP-GRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
68-115 1.57e-10

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 55.69  E-value: 1.57e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1955843287   68 RGHFTDHEDNMIVHLQALLG-NRWAAIASYLPQRTDNDIKNYWNTHLKK 115
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 71-113 7.96e-10

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 53.35  E-value: 7.96e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1955843287  71 FTDHEDNMIVHLQALLG-NRWAAIASYLPQRTDNDIKNYWNTHL 113
Cdd:cd00167     2 WTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 18-76 8.58e-07

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 45.38  E-value: 8.58e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1955843287  18 WTPEEDIILVSYIHQHGpGNWRSVPNNTGLlRCSKSCRLRWTNYLRPGIKRGHFTDHED 76
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGR-RTPKQCFDRWRRKLNPKISRGPWSKEED 57
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 71-118 1.36e-04

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 39.22  E-value: 1.36e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1955843287  71 FTDHEDNMIVHLQALLGNRWAAIASYLPQRTDNDIKNYWNTHLKKKLK 118
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGNDWKQIAKELGRRTPKQCFDRWRRKLNPKIS 48
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 17-39 8.74e-03

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 33.69  E-value: 8.74e-03
                          10        20
                  ....*....|....*....|...
gi 1955843287  17 PWTPEEDIILVSYIHQHGPGNWR 39
Cdd:cd11660     2 KWTDEEDEALVEGVEKYGVGNWA 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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