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Conserved domains on  [gi|1951336734|ref|XP_038570831|]
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selection and upkeep of intraepithelial T-cells protein 1-like [Micropterus salmoides]

Protein Classification

immunoglobulin domain-containing family protein( domain architecture ID 34076)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 30-135 4.78e-29

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05713:

Pssm-ID: 472250  Cd Length: 114  Bit Score: 106.12  E-value: 4.78e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951336734  30 QLIGSSRPIVVSLGDDIILPCRVEPLLNVEDLTVEWWRpdlprdpeDPLSPYkhVHRYRDNHDVEDMNMSSYAGRTTLFK 109
Cdd:cd05713     2 SVIGPTEPILALVGEDAELPCHLSPKMSAEHMEVRWFR--------SQFSPV--VHLYRDGQDQEEEQMPEYRGRTELLK 71

                          90       100
                  ....*....|....*....|....*.
gi 1951336734 110 DELKHGNASLKILNVKLSDQGSYRCF 135
Cdd:cd05713    72 DAIAEGSVALRIHNVRPSDEGQYTCF 97
 
Name Accession Description Interval E-value
IgV_MOG_like cd05713
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here ...
 30-135 4.78e-29

Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here are composed of the immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG). MOG, a minor component of the myelin sheath, is an important CNS-specific autoantigen, linked to the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). It is a transmembrane protein having an extracellular Ig domain. MOG is expressed in the CNS on the outermost lamellae of the myelin sheath, and on the surface of oligodendrocytes, and may participate in the completion, compaction, and/or maintenance of myelin. This group also includes butyrophilin (BTN). BTN is the most abundant protein in bovine milk-fat globule membrane (MFGM).


Pssm-ID: 409378  Cd Length: 114  Bit Score: 106.12  E-value: 4.78e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951336734  30 QLIGSSRPIVVSLGDDIILPCRVEPLLNVEDLTVEWWRpdlprdpeDPLSPYkhVHRYRDNHDVEDMNMSSYAGRTTLFK 109
Cdd:cd05713     2 SVIGPTEPILALVGEDAELPCHLSPKMSAEHMEVRWFR--------SQFSPV--VHLYRDGQDQEEEQMPEYRGRTELLK 71

                          90       100
                  ....*....|....*....|....*.
gi 1951336734 110 DELKHGNASLKILNVKLSDQGSYRCF 135
Cdd:cd05713    72 DAIAEGSVALRIHNVRPSDEGQYTCF 97
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 34-134 3.28e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 53.23  E-value: 3.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951336734  34 SSRPIVVSLGDDIILPCRVEPLLNVEDLTVEWWRpdlprdpEDPLSPYKHVHRYRDNHDvedmNMSSYAGRTTLFKDELK 113
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMSEASTSVYWYR-------QPPGKGPTFLIAYYSNGS----EEGVKKGRFSGRGDPSN 70

                          90       100
                  ....*....|....*....|.
gi 1951336734 114 hGNASLKILNVKLSDQGSYRC 134
Cdd:pfam07686  71 -GDGSLTIQNLTLSDSGTYTC 90
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 35-134 9.09e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.88  E-value: 9.09e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951336734   35 SRPIVVSLGDDIILPCRVEpllNVEDLTVEWWRPDLprdpedplspykhvhryrdnhdvedmNMSSYAGRTTLFKDelkH 114
Cdd:smart00410   1 PPSVTVKEGESVTLSCEAS---GSPPPEVTWYKQGG--------------------------KLLAESGRFSVSRS---G 48

                           90       100
                   ....*....|....*....|
gi 1951336734  115 GNASLKILNVKLSDQGSYRC 134
Cdd:smart00410  49 STSTLTISNVTPEDSGTYTC 68
 
Name Accession Description Interval E-value
IgV_MOG_like cd05713
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here ...
 30-135 4.78e-29

Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here are composed of the immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG). MOG, a minor component of the myelin sheath, is an important CNS-specific autoantigen, linked to the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). It is a transmembrane protein having an extracellular Ig domain. MOG is expressed in the CNS on the outermost lamellae of the myelin sheath, and on the surface of oligodendrocytes, and may participate in the completion, compaction, and/or maintenance of myelin. This group also includes butyrophilin (BTN). BTN is the most abundant protein in bovine milk-fat globule membrane (MFGM).


Pssm-ID: 409378  Cd Length: 114  Bit Score: 106.12  E-value: 4.78e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951336734  30 QLIGSSRPIVVSLGDDIILPCRVEPLLNVEDLTVEWWRpdlprdpeDPLSPYkhVHRYRDNHDVEDMNMSSYAGRTTLFK 109
Cdd:cd05713     2 SVIGPTEPILALVGEDAELPCHLSPKMSAEHMEVRWFR--------SQFSPV--VHLYRDGQDQEEEQMPEYRGRTELLK 71

                          90       100
                  ....*....|....*....|....*.
gi 1951336734 110 DELKHGNASLKILNVKLSDQGSYRCF 135
Cdd:cd05713    72 DAIAEGSVALRIHNVRPSDEGQYTCF 97
IgV_HHLA2 cd16091
Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are ...
 33-136 1.84e-20

Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are composed of the immunoglobulin variable (IgV) region in HERV-H LTR-associating 2 (HHLA2; also known as B7-H7/B7 homolog 7). HHLA2 is a member of the B7 family of immune regulatory proteins. Mature human HHLA2 consists of an extracellular domain (ECD) with three immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic domain. HHLA2 is widely expressed in human cancers including non-small cell lung carcinoma (NSCLS), triple negative breast cancer (TNBC), and melanoma, but has limited expression on normal tissues. Interestingly, unlike other members of B7 family, HHLA2 is not expressed in mice or rats. HHLA2 functions as a T cell coinhibitory molecules as it inhibits the proliferation of activated CD4(+) and CD8(+) T cells and their cytokine production. Furthermore, HHLA2 is constitutively expressed on the surface of human monocytes and is induced on B cells after stimulation, however it is not inducible on T cells.


Pssm-ID: 409512  Cd Length: 107  Bit Score: 83.59  E-value: 1.84e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951336734  33 GSSRPIVVSLGDDIILPCRVEPllnVEDLTVEWWRPDLPRdpedplspykHVHRYRDNHDVEDMNMSSYAGRTTLFKDEL 112
Cdd:cd16091     2 VSEVIVVCLLSEDCILPCSFTP---GSEVVIHWYKQDSDI----------KVHSYYYGKDQLESQDQRYRNRTSLFKDQI 68

                          90       100
                  ....*....|....*....|....
gi 1951336734 113 KHGNASLKILNVKLSDQGSYRCFI 136
Cdd:cd16091    69 SNGNASLLLRRVQLQDEGRYKCYT 92
IgV_B7-H3 cd20934
Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint ...
 37-151 3.54e-17

Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint molecules; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H3 also known as CD276), a member of the B7 family of immune checkpoint molecules. B7-H3 is an important immune checkpoint member of the B7 family and shares homology with other B7 ligands such as programmed death ligand 1 (PD-L1). The B7 family molecules interact with CD28 on T-cells to provide co-stimulatory signals that regulate T-cell activation and T-helper cell differentiation. Although B7-H3 has been shown to have both co-stimulatory and co-inhibitory effects on T-cell responses, the most current studies describe B7-H3 as a T cell inhibitor that promotes tumor aggressiveness and proliferation. Moreover, B7-H3 is highly overexpressed on a wide range of human solid cancers and promotes tumor growth, metastasis, and drug resistance. Thus, B7-H3 expression in tumors often correlates with both negative prognosis and poor clinical outcome in cancer patients. B7-H3 protein contains a predicted signal peptide, V- and C-like Ig domains (IgV and IgC), a transmembrane region, and an intracellular tail.


Pssm-ID: 409528  Cd Length: 115  Bit Score: 74.95  E-value: 3.54e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951336734  37 PIVVSLGDDIILPCRV--EPLLNVEDLTVEWWRPDLPRdpedplspykHVHRYRDNHDVEDMNMSSYAGRTTLFKDELKH 114
Cdd:cd20934     6 PVVALVGTDATLRCSFspEPGFSLAQLSVFWQLTDTKQ----------LVHSFTESQDQGRDQGSAYANRTALFPDLLAQ 75

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1951336734 115 GNASLKILNVKLSDQGSYRCF--IPQLGRATIIRIVVDP 151
Cdd:cd20934    76 GNASLRLQRVRVADEGSYTCFvsVQDFGSAAVSLQVAAP 114
IgV_B7-H4 cd20984
Immunoglobulin Variable (IgV) domain of B7-H4; The members here are composed of the ...
 42-136 8.74e-17

Immunoglobulin Variable (IgV) domain of B7-H4; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H4 (also known as B7-S1, B7x, or Vtcn1). B7-H4 is one of the B7 family of immune-regulatory ligands that act as negative regulators of T cell function; it contains one IgV domain and one IgC domain. The B7-family consists of structurally related cell-surface protein ligands, which bind to receptors on lymphocytes that regulate immune responses. The binding of B7-H4 to unidentified receptors results in the inhibition of TCR-mediated T cell proliferation, cell-cycle progression and IL-2 production. As a co-inhibitory molecule, B7-H4 is widely expressed in tumor tissues and its expression is significantly associated with poor prognosis in human cancers such as glioma, pancreatic cancer, oral squamous cell carcinoma, renal cell carcinoma, and lung cancer.


Pssm-ID: 409576  Cd Length: 110  Bit Score: 73.79  E-value: 8.74e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951336734  42 LGDDIILPCRVEPLLNVEDLTVEWWRPDLPrdpedplspyKHVHRYRD-NHDVEDMNmSSYAGRTTLFKDELKHGNASLK 120
Cdd:cd20984    11 IGEDGILSCTFTPDIKLSDIVIQWLKEGDS----------GLVHEFKEgKDELSRQS-PMFRGRTSLFADQVHVGNASLR 79

                          90
                  ....*....|....*.
gi 1951336734 121 ILNVKLSDQGSYRCFI 136
Cdd:cd20984    80 LKNVQLTDAGTYLCII 95
IgV_PDl1 cd20947
Immunoglobulin Variable (IgV) domain of Programmed death ligand 1 (PD-L1); The members here ...
 39-149 4.96e-12

Immunoglobulin Variable (IgV) domain of Programmed death ligand 1 (PD-L1); The members here are composed of the immunoglobulin variable (IgV) domain of Programmed death ligand 1 (PD-L1; also known as Cluster of Differentiation 274 (CD274)). PD-L1 is a cell-surface ligand that competes with PD-L2 for binding to the immunosuppressive receptor programmed death-1 (PD-1). PD-1 is a member of the B7 family that plays an important role in negatively regulating immune responses upon interaction with its two ligands, PD-L1 or PD-L2. Like PD-L2, PD-L1 interacts with PD-1 and suppresses T cell proliferation and cytokine production. The PD-1 receptor is expressed on the surface of activated T cells, while PD-L1 is expressed on cancer cells. When PD-1 and PD-L1 bind together, they form a molecular shield protecting tumor cells from being destroyed by the immune system. Thus, inhibiting the binding of PD-L1 to PD-1 with an antibody leads to killing of tumor cells by T cells. PD-1 inhibitors (such as Pembrolizumab, Nivolumab, and Cemiplimab) and PD-L1 inhibitors (such as Atezolizumab, Avelumab, and Durvalumab ) are an emerging class of immunotherapy that stimulate lymphocytes against tumor cells.


Pssm-ID: 409539  Cd Length: 110  Bit Score: 61.10  E-value: 4.96e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951336734  39 VVSLGDDIILPCR--VEPLLNVEDLTVEWWRPDlprdpedplspyKHVHRYRdnHDVEDMNM--SSYAGRTTLFKDELKH 114
Cdd:cd20947     9 VVEYGSNMTIECKfpVEKQLDLAALIVYWEMED------------KNIIQFV--HGEEDLKVqhSSYRQRARLLKDQLSL 74

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1951336734 115 GNASLKILNVKLSDQGSYRCFIpQLGRATIIRIVV 149
Cdd:cd20947    75 GNAALQITDVKLQDAGVYRCMI-SYGGADYKRITV 108
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 34-134 3.28e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 53.23  E-value: 3.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951336734  34 SSRPIVVSLGDDIILPCRVEPLLNVEDLTVEWWRpdlprdpEDPLSPYKHVHRYRDNHDvedmNMSSYAGRTTLFKDELK 113
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMSEASTSVYWYR-------QPPGKGPTFLIAYYSNGS----EEGVKKGRFSGRGDPSN 70

                          90       100
                  ....*....|....*....|.
gi 1951336734 114 hGNASLKILNVKLSDQGSYRC 134
Cdd:pfam07686  71 -GDGSLTIQNLTLSDSGTYTC 90
I-set pfam07679
Immunoglobulin I-set domain;
29-134 2.86e-06

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 44.56  E-value: 2.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951336734  29 PQLIGSSRPIVVSLGDDIILPCRVEpllNVEDLTVEWWRPDLprdpedPLSPYKHvHRYRDNhdvedmnmssyagrttlf 108
Cdd:pfam07679   1 PKFTQKPKDVEVQEGESARFTCTVT---GTPDPEVSWFKDGQ------PLRSSDR-FKVTYE------------------ 52

                          90       100
                  ....*....|....*....|....*.
gi 1951336734 109 kdelkHGNASLKILNVKLSDQGSYRC 134
Cdd:pfam07679  53 -----GGTYTLTISNVQPDDSGKYTC 73
IgV_CAR_like cd20960
Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and ...
 43-141 8.04e-06

Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins; The members here are composed of the Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins. CAR, which is encoded by human CXADR gene, is a cell adhesion molecule of the Immunoglobulin (Ig) superfamily. The CAR acts as a type I membrane receptor for group B1-B6 coxsackie viruses and subgroup C adenoviruses. For instance, adenovirus interacts with the coxsackievirus and adenovirus receptor to enter epithelial airway cells. The CAR is also shown to be involved in physiological processes such as neuronal and heart development, epithelial tight junction integrity, and tumor suppression. The CAR is a component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. The CAR is also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. The CAR is composed of one V-set and one C2-set Ig module, a single transmembrane helix, and an intracellular domain. This group belongs to the V-set of IgSF domains, having A, B, E and D strands in one beta-sheet and A', G, F, C, C' and C" in the other


Pssm-ID: 409552  Cd Length: 114  Bit Score: 43.98  E-value: 8.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951336734  43 GDDIILPCRVEplLNVED---LTVEWWRpdLPRDPEDP-LSPYKHVHRYRDNHDVEdmnmssyAGRTTlFKDELKHGNAS 118
Cdd:cd20960    15 GENVTLPCHHQ--LGLEDqgtLDIEWLL--LPSDKVEKvVITYSGDRVYNHYYPAL-------KGRVA-FTSNDLSGDAS 82

                          90       100
                  ....*....|....*....|...
gi 1951336734 119 LKILNVKLSDQGSYRCFIPQLGR 141
Cdd:cd20960    83 LNISNLKLSDTGTYQCKVKKAPG 105
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 35-134 9.09e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.88  E-value: 9.09e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951336734   35 SRPIVVSLGDDIILPCRVEpllNVEDLTVEWWRPDLprdpedplspykhvhryrdnhdvedmNMSSYAGRTTLFKDelkH 114
Cdd:smart00410   1 PPSVTVKEGESVTLSCEAS---GSPPPEVTWYKQGG--------------------------KLLAESGRFSVSRS---G 48

                           90       100
                   ....*....|....*....|
gi 1951336734  115 GNASLKILNVKLSDQGSYRC 134
Cdd:smart00410  49 STSTLTISNVTPEDSGTYTC 68
IGv smart00406
Immunoglobulin V-Type;
45-136 9.98e-06

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 42.75  E-value: 9.98e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951336734   45 DIILPCRVEPLLNVeDLTVEWWRpdlprdpEDPLSPYKHVHRYRDNHDVEDMnmSSYAGRTTLFKDELKhGNASLKILNV 124
Cdd:smart00406   1 SVTLSCKFSGSTFS-SYYVSWVR-------QPPGKGLEWLGYIGSNGSSYYQ--ESYKGRFTISKDTSK-NDVSLTISNL 69

                           90
                   ....*....|..
gi 1951336734  125 KLSDQGSYRCFI 136
Cdd:smart00406  70 RVEDTGTYYCAV 81
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 29-134 8.58e-05

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 40.24  E-value: 8.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951336734  29 PQLIGSSRPIVVSLGDDIILPCRVEpllNVEDLTVEWWRPDLPRDPEDPLSpykhvhryrdnhdvedmnmssyagrttlf 108
Cdd:pfam13927   2 PVITVSPSSVTVREGETVTLTCEAT---GSPPPTITWYKNGEPISSGSTRS----------------------------- 49

                          90       100
                  ....*....|....*....|....*.
gi 1951336734 109 kDELKHGNASLKILNVKLSDQGSYRC 134
Cdd:pfam13927  50 -RSLSGSNSTLTISNVTRSDAGTYTC 74
IgV_B7-H6 cd20981
Immunoglobulin variable (IgV) domain of B7-H6; The members here are composed of the ...
 39-157 5.14e-04

Immunoglobulin variable (IgV) domain of B7-H6; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H6 (also known as NCR3LG1). B7-H6 contains one IgV domain and one IgC domain (IgV-IgC) and belongs to the B7-family, which consists of structurally related cell-surface protein ligands which bind to receptors on lymphocytes that regulate immune responses. B7-H6 is a ligand of NKp30, which is a member of CD28 family and an activating receptor of natural killer (NK) cells. The expression of NKp30 has been found in most of NK cells, which is involved in the process of tumor cell killing and interaction with antigen presenting cells (APCs) such as dendritic cells. Studies showed that NK cells eliminate B7-H6-expressing tumor cells either directly via cytotoxicity or indirectly by cytokine secretion. For instance, chimeric NKp30-expressing T cells responded to B7-H6(+) tumor cells and those T cells produced IFN-gamma and killed B7-H6-expressing tumor cells in vivo. B7-H6 mRNA is not found in normal cells, while high expression of B7-H6 is found in certain type tumor cells, such as lymphoma, leukemia, ovarian cancer, brain tumors, breast cancers, and various sarcomas. Since B7-H6 can bind NKp30 to exert anti-tumor effects by NK cells, which are able to recognize the difference between cancer cells and normal cells, B7-H6 may serve as a promising target for cancer immunotherapy.


Pssm-ID: 409573  Cd Length: 114  Bit Score: 38.75  E-value: 5.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951336734  39 VVSLGDDIILPCRV--EPLLNVEDLTVEWWRPDLPRDPEdplspYKHVHRYRDNhdvedmnMSSYAGRTTLFKDELKHGN 116
Cdd:cd20981    12 ITPLNDNVTIFCNIfySQPLNITSMGITWFRKSLTFDKE-----VKVFEFFGDH-------QKAFRPGAIVSPWRLKSGD 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1951336734 117 ASLKILNVKLSDQGSYRCfipqlgratiiRIVVDPDTVKTW 157
Cdd:cd20981    80 ASLQLPGVQLEEAGEYRC-----------EVVVTPLKAQGT 109
IgV_PD-L2 cd20983
Immunoglobulin Variable (IgV) domain of Programmed death ligand 2 (PD-L2); The members here ...
 93-136 8.24e-04

Immunoglobulin Variable (IgV) domain of Programmed death ligand 2 (PD-L2); The members here are composed of the immunoglobulin variable (IgV) domain of Programmed death ligand 2 (PD-L2; also known as B7-DC or CD273). Receptor-binding domain of PD-L2 is a cell-surface ligand that competes with PD-L1 for binding to the immunosuppressive receptor programmed death-1 (PD-1). PD-1 is a member of the CD28/B7 family that plays an important role in negatively regulating immune responses upon interaction with its two ligands, PD-L1 or PD-L2. PD-L2 has a higher affinity for PD-1 but is expressed at lower levels. PD-L2 interaction with PD-1 suppresses T cell proliferation, cytokine production and cytotoxic activity. PD-L2 is expressed on tumor cells, antigen-presenting cells or APCs (such as macrophages, B cells and dendritic cells), and a variety of other immune and nonimmune cells. Tumor expression of PD-L2 may contribute to tumor evasion of immune destruction by inactivating T cells. Thus, PD-L2 is a negative predictor for prognosis among solid cancer patients.


Pssm-ID: 409575  Cd Length: 100  Bit Score: 37.94  E-value: 8.24e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1951336734  93 VEDmNMSSYAGRTTLFKDELKHGNASLKILNVKLSDQGSYRCFI 136
Cdd:cd20983    43 VEN-DTSLHSERATLLEEQLPLGKALFHIPSVQVRDAGQYRCLI 85
IgV_CD86 cd16087
Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 86; The members here ...
 99-136 8.72e-04

Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 86; The members here are composed of the immunoglobulin variable region (IgV) in the Cluster of Differentiation (CD) 86). Glycoproteins B7-1 (also known as cluster of differentiation (CD) 80) and B7-2 (also known as CD86) are expressed on antigen-presenting cells and deliver the co-stimulatory signal through CD28 and CTLA-4 (also known as CD152) on T cells. signaling through CD28 augments the T-cell response, whereas CTLA-4 signaling attenuates it. The CTLA-4 and B7-2 monomers are both two-layer beta-sandwiches that display the chain topology characteristic of the immunoglobulin variable (V-type) domains present in antigen receptors. The front and back sheets of B7-2 are composed of AGFCC'C" and BED strands, respectively. Members of the IgV family are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond.


Pssm-ID: 409508  Cd Length: 108  Bit Score: 38.08  E-value: 8.72e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1951336734  99 SSYAGRTTLFKDelkhgNASLKILNVKLSDQGSYRCFI 136
Cdd:cd16087    55 SKYIGRTSFDQE-----NWTLQLHNVQIKDQGTYQCFI 87
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 34-134 1.33e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 36.79  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951336734  34 SSRPIVVSLGDDIILPCRVEPllNVEDLTVEWWRPDlprdPEDPLSPYKHVHRYRdnhdvedmnmssyagrttlfkdelk 113
Cdd:pfam00047   2 APPTVTVLEGDSATLTCSAST--GSPGPDVTWSKEG----GTLIESLKVKHDNGR------------------------- 50

                          90       100
                  ....*....|....*....|.
gi 1951336734 114 HGNASLKILNVKLSDQGSYRC 134
Cdd:pfam00047  51 TTQSSLLISNVTKEDAGTYTC 71
Ig_Versican cd05901
Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), ...
 32-134 2.42e-03

Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican; The members here are composed of the immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican. In CSPGs, the Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, the CSPG aggrecan (not included in this group) forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Like aggrecan, versican has a wide distribution in connective tissue and extracellular matrices. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409482  Cd Length: 128  Bit Score: 37.25  E-value: 2.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951336734  32 IGSSRPIVVSLGDDIILPCR------VEPLLNV--EDLTVEWWRPDLPRDPEDPLSPYKHVHRyrdNHDVEdmNMSSYAG 103
Cdd:cd05901     1 VRKSSRVHGSLSGSVVLPCRfstlptLPPSYNItsEFLRIKWTKIQVDKNGKDHKETTVLVAQ---NGIIK--IGQEYMG 75

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1951336734 104 RTTLFKDELKHGNASLKILNVKLSDQGSYRC 134
Cdd:cd05901    76 RVSVPSHPEDQGDASLTIVKLRASDAGVYRC 106
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 105-134 3.63e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 35.38  E-value: 3.63e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1951336734 105 TTLFKDELKHGNASLKILNVKLSDQGSYRC 134
Cdd:cd00096    27 SSRDSRRSELGNGTLTISNVTLEDSGTYTC 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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