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Conserved domains on  [gi|1952979629|ref|XP_038412412|]
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muskelin isoform X2 [Canis lupus familiaris]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Muskelin_N pfam06588
Muskelin N-terminus; This family represents the N-terminal region of muskelin and is found in ...
 12-207 2.33e-123

Muskelin N-terminus; This family represents the N-terminal region of muskelin and is found in conjunction with several pfam01344 repeats. Muskelin is an intracellular, kelch repeat protein that is needed in cell-spreading responses to the matrix adhesion molecule, thrombospondin-1.


:

Pssm-ID: 284099  Cd Length: 197  Bit Score: 366.07  E-value: 2.33e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979629  12 ECRLLPYALHKWSSFSSTYLPENILVDKPNDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCNLKKFKVFG 91
Cdd:pfam06588   1 EYSVLPYEIHSYSSYSSVYLPENILVDDPNDQNSRWSTSTNSPPQYLILKLPRPAIVTTITFGKYEKMHVCNLKKFRVYG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979629  92 GMNEENMTELLSSGLKNDYNKETFTLKHKI-DEQMFPCRFIKIVPLLSWGPSFNFSIWYVELSGIDDPDVVQPCLNWYSK 170
Cdd:pfam06588  81 GRDGEEMRELLCGGLKNDSNMETFNLLVKDyNEIYFPCQYIKIVPLLAWGPSFNFSIWYVELHGIDDPSAVSEFVKNYEM 160

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1952979629 171 YREQEAIRLCLKHFRQHNYTEAFESLQKKTKIALEHP 207
Cdd:pfam06588 161 VREGEAIRLCLKHFRQCGYLDIFEILQKRTSDKIEHP 197
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
284-559 2.76e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 67.87  E-value: 2.76e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979629 284 TVYLFGGWDGTQDLADFWAYSVKENQWtcisrdTEKENGPSARSCHKMCIdIQRRQIYTLGRYldSSVRNSKSLKSDFYR 363
Cdd:COG3055    24 KVYVAGGLSGGSASNSFEVYDPATNTW------SELAPLPGPPRHHAAAV-AQDGKLYVFGGF--TGANPSSTPLNDVYV 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979629 364 YDIDTNTWmllsedTAADGGPKLVFDHQMCMDSEKhmIYTFGGRilTCNGSVDDsrasepqfsgLFAFNCQCQTWKLLre 443
Cdd:COG3055    95 YDPATNTW------TKLAPMPTPRGGATALLLDGK--IYVVGGW--DDGGNVAW----------VEVYDPATGTWTQL-- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979629 444 dscnagPEDIQSRIGHCMLFHSKNRcLYVFGGQRSktylndffsydvdsdhvdiiSDGTKKDSGMVPMTGFTQRATIDPE 523
Cdd:COG3055   153 ------APLPTPRDHLAAAVLPDGK-ILVIGGRNG--------------------SGFSNTWTTLAPLPTARAGHAAAVL 205

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1952979629 524 LNEIHVLSGlskdkekrEENVRNSFWIYDIVRNSWS 559
Cdd:COG3055   206 GGKILVFGG--------ESGFSDEVEAYDPATNTWT 233
 
Name Accession Description Interval E-value
Muskelin_N pfam06588
Muskelin N-terminus; This family represents the N-terminal region of muskelin and is found in ...
 12-207 2.33e-123

Muskelin N-terminus; This family represents the N-terminal region of muskelin and is found in conjunction with several pfam01344 repeats. Muskelin is an intracellular, kelch repeat protein that is needed in cell-spreading responses to the matrix adhesion molecule, thrombospondin-1.


Pssm-ID: 284099  Cd Length: 197  Bit Score: 366.07  E-value: 2.33e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979629  12 ECRLLPYALHKWSSFSSTYLPENILVDKPNDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCNLKKFKVFG 91
Cdd:pfam06588   1 EYSVLPYEIHSYSSYSSVYLPENILVDDPNDQNSRWSTSTNSPPQYLILKLPRPAIVTTITFGKYEKMHVCNLKKFRVYG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979629  92 GMNEENMTELLSSGLKNDYNKETFTLKHKI-DEQMFPCRFIKIVPLLSWGPSFNFSIWYVELSGIDDPDVVQPCLNWYSK 170
Cdd:pfam06588  81 GRDGEEMRELLCGGLKNDSNMETFNLLVKDyNEIYFPCQYIKIVPLLAWGPSFNFSIWYVELHGIDDPSAVSEFVKNYEM 160

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1952979629 171 YREQEAIRLCLKHFRQHNYTEAFESLQKKTKIALEHP 207
Cdd:pfam06588 161 VREGEAIRLCLKHFRQCGYLDIFEILQKRTSDKIEHP 197
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
284-559 2.76e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 67.87  E-value: 2.76e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979629 284 TVYLFGGWDGTQDLADFWAYSVKENQWtcisrdTEKENGPSARSCHKMCIdIQRRQIYTLGRYldSSVRNSKSLKSDFYR 363
Cdd:COG3055    24 KVYVAGGLSGGSASNSFEVYDPATNTW------SELAPLPGPPRHHAAAV-AQDGKLYVFGGF--TGANPSSTPLNDVYV 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979629 364 YDIDTNTWmllsedTAADGGPKLVFDHQMCMDSEKhmIYTFGGRilTCNGSVDDsrasepqfsgLFAFNCQCQTWKLLre 443
Cdd:COG3055    95 YDPATNTW------TKLAPMPTPRGGATALLLDGK--IYVVGGW--DDGGNVAW----------VEVYDPATGTWTQL-- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979629 444 dscnagPEDIQSRIGHCMLFHSKNRcLYVFGGQRSktylndffsydvdsdhvdiiSDGTKKDSGMVPMTGFTQRATIDPE 523
Cdd:COG3055   153 ------APLPTPRDHLAAAVLPDGK-ILVIGGRNG--------------------SGFSNTWTTLAPLPTARAGHAAAVL 205

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1952979629 524 LNEIHVLSGlskdkekrEENVRNSFWIYDIVRNSWS 559
Cdd:COG3055   206 GGKILVFGG--------ESGFSDEVEAYDPATNTWT 233
Kelch_3 pfam13415
Galactose oxidase, central domain;
282-334 3.90e-07

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 47.28  E-value: 3.90e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1952979629 282 TETVYLFGGWD--GTQDLADFWAYSVKENQWTCISrdtekeNGPSARSCHKMCID 334
Cdd:pfam13415   1 GDKLYIFGGLGfdGQTRLNDLYVYDLDTNTWTQIG------DLPPPRSGHSATYI 49
PLN02153 PLN02153
epithiospecifier protein
 307-475 1.39e-06

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 51.14  E-value: 1.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979629 307 ENQWtcISRDTEKENGPSARSCHKMCIdiQRRQIYTLGryldSSVRNSKSLKSDFYRYDIDTNTWMLlsedTAADGGPKL 386
Cdd:PLN02153    6 QGGW--IKVEQKGGKGPGPRCSHGIAV--VGDKLYSFG----GELKPNEHIDKDLYVFDFNTHTWSI----APANGDVPR 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979629 387 VFDHQMCMDSEKHMIYTFGGRiltcngsvDDSRAsepqFSGLFAFNCQCQTWKLLREDSCNAGPEdiqSRIGHCMLfhSK 466
Cdd:PLN02153   74 ISCLGVRMVAVGTKLYIFGGR--------DEKRE----FSDFYSYDTVKNEWTFLTKLDEEGGPE---ARTFHSMA--SD 136


                  ....*....
gi 1952979629 467 NRCLYVFGG 475
Cdd:PLN02153  137 ENHVYVFGG 145
Kelch smart00612
Kelch domain;
285-311 1.36e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 37.15  E-value: 1.36e-03
                           10        20
                   ....*....|....*....|....*..
gi 1952979629  285 VYLFGGWDGTQDLADFWAYSVKENQWT 311
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWT 28
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 172-202 9.50e-03

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 34.33  E-value: 9.50e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1952979629  172 REQEAIRLCLKHFRQHNYTEAFESLQKKTKI 202
Cdd:smart00667   2 SRSELNRLILEYLLRNGYEETAETLQKESGL 32
 
Name Accession Description Interval E-value
Muskelin_N pfam06588
Muskelin N-terminus; This family represents the N-terminal region of muskelin and is found in ...
 12-207 2.33e-123

Muskelin N-terminus; This family represents the N-terminal region of muskelin and is found in conjunction with several pfam01344 repeats. Muskelin is an intracellular, kelch repeat protein that is needed in cell-spreading responses to the matrix adhesion molecule, thrombospondin-1.


Pssm-ID: 284099  Cd Length: 197  Bit Score: 366.07  E-value: 2.33e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979629  12 ECRLLPYALHKWSSFSSTYLPENILVDKPNDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCNLKKFKVFG 91
Cdd:pfam06588   1 EYSVLPYEIHSYSSYSSVYLPENILVDDPNDQNSRWSTSTNSPPQYLILKLPRPAIVTTITFGKYEKMHVCNLKKFRVYG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979629  92 GMNEENMTELLSSGLKNDYNKETFTLKHKI-DEQMFPCRFIKIVPLLSWGPSFNFSIWYVELSGIDDPDVVQPCLNWYSK 170
Cdd:pfam06588  81 GRDGEEMRELLCGGLKNDSNMETFNLLVKDyNEIYFPCQYIKIVPLLAWGPSFNFSIWYVELHGIDDPSAVSEFVKNYEM 160

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1952979629 171 YREQEAIRLCLKHFRQHNYTEAFESLQKKTKIALEHP 207
Cdd:pfam06588 161 VREGEAIRLCLKHFRQCGYLDIFEILQKRTSDKIEHP 197
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
284-559 2.76e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 67.87  E-value: 2.76e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979629 284 TVYLFGGWDGTQDLADFWAYSVKENQWtcisrdTEKENGPSARSCHKMCIdIQRRQIYTLGRYldSSVRNSKSLKSDFYR 363
Cdd:COG3055    24 KVYVAGGLSGGSASNSFEVYDPATNTW------SELAPLPGPPRHHAAAV-AQDGKLYVFGGF--TGANPSSTPLNDVYV 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979629 364 YDIDTNTWmllsedTAADGGPKLVFDHQMCMDSEKhmIYTFGGRilTCNGSVDDsrasepqfsgLFAFNCQCQTWKLLre 443
Cdd:COG3055    95 YDPATNTW------TKLAPMPTPRGGATALLLDGK--IYVVGGW--DDGGNVAW----------VEVYDPATGTWTQL-- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979629 444 dscnagPEDIQSRIGHCMLFHSKNRcLYVFGGQRSktylndffsydvdsdhvdiiSDGTKKDSGMVPMTGFTQRATIDPE 523
Cdd:COG3055   153 ------APLPTPRDHLAAAVLPDGK-ILVIGGRNG--------------------SGFSNTWTTLAPLPTARAGHAAAVL 205

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1952979629 524 LNEIHVLSGlskdkekrEENVRNSFWIYDIVRNSWS 559
Cdd:COG3055   206 GGKILVFGG--------ESGFSDEVEAYDPATNTWT 233
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 24-152 9.60e-09

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 53.99  E-value: 9.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979629  24 SSFSSTYLPENiLVDkpNDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCNLKKFKVFGGMNEENMTELLS 103
Cdd:pfam00754   6 SSYSGEGPAAA-ALD--GDPNTAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQDGSNGYVTSYKIEYSLDGENWTTVKD 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1952979629 104 SGLKNDYNKETftlkhkIDEQMFPC----RFIKIVPlLSWGPSFNFSIWyVEL 152
Cdd:pfam00754  83 EKIPGNNDNNT------PVTNTFDPpikaRYVRIVP-TSWNGGNGIALR-AEL 127
Kelch_3 pfam13415
Galactose oxidase, central domain;
282-334 3.90e-07

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 47.28  E-value: 3.90e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1952979629 282 TETVYLFGGWD--GTQDLADFWAYSVKENQWTCISrdtekeNGPSARSCHKMCID 334
Cdd:pfam13415   1 GDKLYIFGGLGfdGQTRLNDLYVYDLDTNTWTQIG------DLPPPRSGHSATYI 49
PLN02153 PLN02153
epithiospecifier protein
 307-475 1.39e-06

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 51.14  E-value: 1.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979629 307 ENQWtcISRDTEKENGPSARSCHKMCIdiQRRQIYTLGryldSSVRNSKSLKSDFYRYDIDTNTWMLlsedTAADGGPKL 386
Cdd:PLN02153    6 QGGW--IKVEQKGGKGPGPRCSHGIAV--VGDKLYSFG----GELKPNEHIDKDLYVFDFNTHTWSI----APANGDVPR 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979629 387 VFDHQMCMDSEKHMIYTFGGRiltcngsvDDSRAsepqFSGLFAFNCQCQTWKLLREDSCNAGPEdiqSRIGHCMLfhSK 466
Cdd:PLN02153   74 ISCLGVRMVAVGTKLYIFGGR--------DEKRE----FSDFYSYDTVKNEWTFLTKLDEEGGPE---ARTFHSMA--SD 136


                  ....*....
gi 1952979629 467 NRCLYVFGG 475
Cdd:PLN02153  137 ENHVYVFGG 145
PLN02153 PLN02153
epithiospecifier protein
 285-376 4.87e-06

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 49.21  E-value: 4.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979629 285 VYLFGGWDGTQDLADFWAYSVKENQWTCISRdTEKENGPSARSCHKMCIDiqRRQIYTLGRYLDSSVRNSKSLKSDFYRY 364
Cdd:PLN02153   88 LYIFGGRDEKREFSDFYSYDTVKNEWTFLTK-LDEEGGPEARTFHSMASD--ENHVYVFGGVSKGGLMKTPERFRTIEAY 164

                          90
                  ....*....|..
gi 1952979629 365 DIDTNTWMLLSE 376
Cdd:PLN02153  165 NIADGKWVQLPD 176
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 270-314 5.31e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 43.75  E-value: 5.31e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1952979629 270 MRGGHQMVidVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCIS 314
Cdd:pfam01344   1 RRSGAGVV--VVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLP 43
PLN02193 PLN02193
nitrile-specifier protein
 284-386 1.10e-04

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 45.33  E-value: 1.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979629 284 TVYLFGGWDGTQDLADFWAYSVKENQWTCIsrdTEKENGPSARSCHKMCIDiqRRQIYTLGRYldSSVRNSKSLKSdfyr 363
Cdd:PLN02193  230 TLYVFGGRDASRQYNGFYSFDTTTNEWKLL---TPVEEGPTPRSFHSMAAD--EENVYVFGGV--SATARLKTLDS---- 298

                          90       100
                  ....*....|....*....|....*.
gi 1952979629 364 YDIDTNTWMLLS---EDTAADGGPKL 386
Cdd:PLN02193  299 YNIVDKKWFHCStpgDSFSIRGGAGL 324
PLN02153 PLN02153
epithiospecifier protein
 371-558 2.43e-04

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 43.82  E-value: 2.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979629 371 WMLLSEDTAADGGPKLvfDHQMCMDSEKhmIYTFGGRiLTCNGSVDDSrasepqfsgLFAFNCQCQTWKLLredSCNAGP 450
Cdd:PLN02153    9 WIKVEQKGGKGPGPRC--SHGIAVVGDK--LYSFGGE-LKPNEHIDKD---------LYVFDFNTHTWSIA---PANGDV 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979629 451 EDIqSRIGHCMLfhSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIIsdgTKKDSGMVPMTGFTQRATIDPelNEIHVL 530
Cdd:PLN02153   72 PRI-SCLGVRMV--AVGTKLYIFGGRDEKREFSDFYSYDTVKNEWTFL---TKLDEEGGPEARTFHSMASDE--NHVYVF 143

                         170       180
                  ....*....|....*....|....*...
gi 1952979629 531 SGLSKDKEKREENVRNSFWIYDIVRNSW 558
Cdd:PLN02153  144 GGVSKGGLMKTPERFRTIEAYNIADGKW 171
Kelch_4 pfam13418
Galactose oxidase, central domain;
271-314 4.40e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 38.36  E-value: 4.40e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1952979629 271 RGGHQMVIdVQTETVYLFGG--WDGTQdLADFWAYSVKENQWTCIS 314
Cdd:pfam13418   2 RAYHTSTS-IPDDTIYLFGGegEDGTL-LSDLWVFDLSTNEWTRLG 45
PLN02193 PLN02193
nitrile-specifier protein
 383-558 6.00e-04

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 43.02  E-value: 6.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979629 383 GPKLVFDHQMCMDSEKhmIYTFGGRiLTCNGSVDDSrasepqfsgLFAFNCQCQTWKLlredSCNAGPEDIQSRIGHCML 462
Cdd:PLN02193  162 GPGLRCSHGIAQVGNK--IYSFGGE-FTPNQPIDKH---------LYVFDLETRTWSI----SPATGDVPHLSCLGVRMV 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952979629 463 fhSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIIsdgTKKDSGMVPMTGFTQRAtidpELNEIHVLSGLSKdkekree 542
Cdd:PLN02193  226 --SIGSTLYVFGGRDASRQYNGFYSFDTTTNEWKLL---TPVEEGPTPRSFHSMAA----DEENVYVFGGVSA------- 289

                         170
                  ....*....|....*..
gi 1952979629 543 NVR-NSFWIYDIVRNSW 558
Cdd:PLN02193  290 TARlKTLDSYNIVDKKW 306
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 456-493 1.20e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 37.21  E-value: 1.20e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1952979629 456 RIGHCMLFHskNRCLYVFGGQRSKTYLNDFFSYDVDSD 493
Cdd:pfam01344   2 RSGAGVVVV--GGKIYVIGGFDGNQSLNSVEVYDPETN 37
Kelch smart00612
Kelch domain;
285-311 1.36e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 37.15  E-value: 1.36e-03
                           10        20
                   ....*....|....*....|....*..
gi 1952979629  285 VYLFGGWDGTQDLADFWAYSVKENQWT 311
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWT 28
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 172-202 9.50e-03

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 34.33  E-value: 9.50e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1952979629  172 REQEAIRLCLKHFRQHNYTEAFESLQKKTKI 202
Cdd:smart00667   2 SRSELNRLILEYLLRNGYEETAETLQKESGL 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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