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Conserved domains on  [gi|1949697010|ref|XP_038194190|]
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ubiquinone biosynthesis monooxygenase COQ6, mitochondrial [Arvicola amphibius]

Protein Classification

Rossmann-fold NAD(P)-binding domain-containing protein( domain architecture ID 229380)

Rossmann-fold NAD(P)-binding domain-containing protein may function as an oxidoreductase

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NADB_Rossmann super family cl21454
Rossmann-fold NAD(P)(+)-binding proteins; A large family of proteins that share a ...
 56-471 0e+00

Rossmann-fold NAD(P)(+)-binding proteins; A large family of proteins that share a Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The NADB domain is found in numerous dehydrogenases of metabolic pathways such as glycolysis, and many other redox enzymes. NAD binding involves numerous hydrogen-bonds and van der Waals contacts, in particular H-bonding of residues in a turn between the first strand and the subsequent helix of the Rossmann-fold topology. Characteristically, this turn exhibits a consensus binding pattern similar to GXGXXG, in which the first 2 glycines participate in NAD(P)-binding, and the third facilitates close packing of the helix to the beta-strand. Typically, proteins in this family contain a second domain in addition to the NADB domain, which is responsible for specifically binding a substrate and catalyzing a particular enzymatic reaction.


The actual alignment was detected with superfamily member TIGR01989:

Pssm-ID: 473865 [Multi-domain]  Cd Length: 437  Bit Score: 636.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010  56 AAMACALGHDIHFRDKKILLLEAG--PKK---VLEKLSDTYSNRVSSISPGSATLLSSFGAWDHICNMRCKAFRRMQVWD 130
Cdd:TIGR01989  13 LALAAALGNNPLTKDLKVLLLDAVdnPKLksrNYEKPDGPYSNRVSSITPASISFFKKIGAWDHIQSDRIQPFGRMQVWD 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 131 SCSEALIMFDRDN-LDDMGYIVENDVIMCALTKQLEAV-ADRVRVLYRSKAVDYAWPAPfSMTDSSPWVHITLGDGSTLQ 208
Cdd:TIGR01989  93 GCSLALIRFDRDNgKEDMACIIENDNIQNSLYNRLQEYnGDNVKILNPARLISVTIPSK-YPNDNSNWVHITLSDGQVLY 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 209 TKLLIGADGHNSGVRRAAGIQNVSWTYDQSAVVATLHLSEATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHDHAAE 288
Cdd:TIGR01989 172 TKLLIGADGSNSNVRKAANIDTTGWNYNQHAVVATLKLEEATENDVAWQRFLPTGPIALLPLPDNNSTLVWSTSPEEALR 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 289 LVSMDEEEFVDAINSAF---WSDANHTDFVDSASTMLRYVVTLLKPTRVSARQLPPSIAKVDAKSRALFPLGLGHAAEYV 365
Cdd:TIGR01989 252 LLSLPPEDFVDALNAAFdlgYSDHPYSYLLDYAMEKLNEDIGFRTEGSKSCFQVPPRVIGVVDKSRAAFPLGLGHADEYV 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 366 RPRVALIGDAAHRVHPLAGQGVNMGFGDISSLVRHLSTAAFNGKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLYSTS 445
Cdd:TIGR01989 332 TKRVALVGDAAHRVHPLAGQGVNLGFGDVASLVKALAEAVSVGADIGSISSLKPYERERYAKNVVLLGLVDKLHKLYATD 411

                         410       420
                  ....*....|....*....|....*.
gi 1949697010 446 ATPLVLLRTWGLQATNAVSPLKEQIM 471
Cdd:TIGR01989 412 FPPVVALRTFGLNLTNYIGPLKNFIM 437
 
Name Accession Description Interval E-value
COQ6 TIGR01989
ubiquinone biosynthesis monooxygenase COQ6; This model represents the monooxygenase ...
 56-471 0e+00

ubiquinone biosynthesis monooxygenase COQ6; This model represents the monooxygenase responsible for the 4-hydroxylateion of the phenol ring in the aerobic biosynthesis of ubiquinone


Pssm-ID: 273914 [Multi-domain]  Cd Length: 437  Bit Score: 636.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010  56 AAMACALGHDIHFRDKKILLLEAG--PKK---VLEKLSDTYSNRVSSISPGSATLLSSFGAWDHICNMRCKAFRRMQVWD 130
Cdd:TIGR01989  13 LALAAALGNNPLTKDLKVLLLDAVdnPKLksrNYEKPDGPYSNRVSSITPASISFFKKIGAWDHIQSDRIQPFGRMQVWD 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 131 SCSEALIMFDRDN-LDDMGYIVENDVIMCALTKQLEAV-ADRVRVLYRSKAVDYAWPAPfSMTDSSPWVHITLGDGSTLQ 208
Cdd:TIGR01989  93 GCSLALIRFDRDNgKEDMACIIENDNIQNSLYNRLQEYnGDNVKILNPARLISVTIPSK-YPNDNSNWVHITLSDGQVLY 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 209 TKLLIGADGHNSGVRRAAGIQNVSWTYDQSAVVATLHLSEATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHDHAAE 288
Cdd:TIGR01989 172 TKLLIGADGSNSNVRKAANIDTTGWNYNQHAVVATLKLEEATENDVAWQRFLPTGPIALLPLPDNNSTLVWSTSPEEALR 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 289 LVSMDEEEFVDAINSAF---WSDANHTDFVDSASTMLRYVVTLLKPTRVSARQLPPSIAKVDAKSRALFPLGLGHAAEYV 365
Cdd:TIGR01989 252 LLSLPPEDFVDALNAAFdlgYSDHPYSYLLDYAMEKLNEDIGFRTEGSKSCFQVPPRVIGVVDKSRAAFPLGLGHADEYV 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 366 RPRVALIGDAAHRVHPLAGQGVNMGFGDISSLVRHLSTAAFNGKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLYSTS 445
Cdd:TIGR01989 332 TKRVALVGDAAHRVHPLAGQGVNLGFGDVASLVKALAEAVSVGADIGSISSLKPYERERYAKNVVLLGLVDKLHKLYATD 411

                         410       420
                  ....*....|....*....|....*.
gi 1949697010 446 ATPLVLLRTWGLQATNAVSPLKEQIM 471
Cdd:TIGR01989 412 FPPVVALRTFGLNLTNYIGPLKNFIM 437
PRK08850 PRK08850
2-octaprenyl-6-methoxyphenol hydroxylase; Validated
 70-474 2.52e-75

2-octaprenyl-6-methoxyphenol hydroxylase; Validated


Pssm-ID: 236341 [Multi-domain]  Cd Length: 405  Bit Score: 241.98  E-value: 2.52e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010  70 DKKILLLEAG-PKKVLEKLSDtysNRVSSISPGSATLLSSFGAWDHICNMRCKAFRRMQVWDSCSEALIMFDRDNL--DD 146
Cdd:PRK08850   27 DLRIAVIEGQlPEEALNELPD---VRVSALSRSSEHILRNLGAWQGIEARRAAPYIAMEVWEQDSFARIEFDAESMaqPD 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 147 MGYIVENDVIMCALTKQLEAvADRVRVLYRSKAvdyawpAPFSMTDSSPWvhITLGDGSTLQTKLLIGADGHNSGVRRAA 226
Cdd:PRK08850  104 LGHIVENRVIQLALLEQVQK-QDNVTLLMPARC------QSIAVGESEAW--LTLDNGQALTAKLVVGADGANSWLRRQM 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 227 GIQNVSWTYDQSAVVATLHLSEaTENNVAWQRFLPSGPIALLPLSDT-LSSLVWSTSHDHAAELVSMDEEEFVDAINSAF 305
Cdd:PRK08850  175 DIPLTHWDYGHSALVANVRTVD-PHNSVARQIFTPQGPLAFLPMSEPnMSSIVWSTEPLRAEALLAMSDEQFNKALTAEF 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 306 wsDAnhtdfvdsastmlryvvtllkptrvsarQLppSIAKVDAkSRALFPLGLGHAAEYVRPRVALIGDAAHRVHPLAGQ 385
Cdd:PRK08850  254 --DN----------------------------RL--GLCEVVG-ERQAFPLKMRYARDFVRERVALVGDAAHTIHPLAGQ 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 386 GVNMGFGDISSLVRHLSTAAFNGKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLYSTSATPLVLLRTWGLQATNAVSP 465
Cdd:PRK08850  301 GVNLGLLDAASLAQEILALWQQGRDIGLKRNLRGYERWRKAEAAKMIAAMQGFRDLFSGSNPAKKLVRGIGMSLAGQLPG 380


                  ....*....
gi 1949697010 466 LKEQIMAFA 474
Cdd:PRK08850  381 AKDEIMKRA 389
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 56-467 4.19e-39

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 144.31  E-value: 4.19e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010  56 AAMACAL---GHDIHfrdkkillleagpkkVLEKLSDTYSN-RVSSISPGSATLLSSFGAWDHICnMRCKAFRRMQVWDS 131
Cdd:COG0654    16 LALALALaraGIRVT---------------VVERAPPPRPDgRGIALSPRSLELLRRLGLWDRLL-ARGAPIRGIRVRDG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 132 CS-EALIMFDRDNLD-DMGYIVENDVIMCALTKQLEAvaDRVRVLYRSKAVDYAWpapfsmTDSSpwVHITLGDGSTLQT 209
Cdd:COG0654    80 SDgRVLARFDAAETGlPAGLVVPRADLERALLEAARA--LGVELRFGTEVTGLEQ------DADG--VTVTLADGRTLRA 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 210 KLLIGADGHNSGVRRAAGIQNVSWTYDQSAVVATLHLseatennvawqrflpsgpiallplsdtlsslvwstshdhaael 289
Cdd:COG0654   150 DLVVGADGARSAVRRLLGIGFTGRDYPQRALWAGVRT------------------------------------------- 186

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 290 vsmdeeEFVDAINSAFWsdanhtdfvdsastmlryvvtllkptrvSARQLppsiakVDAKSRALFPLGLGHAAEYVRPRV 369
Cdd:COG0654   187 ------ELRARLAAAGP----------------------------RLGEL------LELSPRSAFPLRRRRAERWRRGRV 226

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 370 ALIGDAAHRVHPLAGQGVNMGFGDISSLVRHLStAAFNGKDLGSMshLTGYETDRQRHNTALLAATDLLKRLYSTSATPL 449
Cdd:COG0654   227 VLLGDAAHTMHPLGGQGANLALRDAAALAWKLA-AALRGRDDEAA--LARYERERRPRAARVQRAADALGRLFHPDSPPL 303

                         410
                  ....*....|....*...
gi 1949697010 450 VLLRTWGLQATNAVSPLK 467
Cdd:COG0654   304 RLLRNAGLRLLDRLPPLK 321
FAD_binding_3 pfam01494
FAD binding domain; This domain is involved in FAD binding in a number of enzymes.
 202-435 6.91e-10

FAD binding domain; This domain is involved in FAD binding in a number of enzymes.


Pssm-ID: 396193 [Multi-domain]  Cd Length: 348  Bit Score: 60.42  E-value: 6.91e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 202 GDGSTLQTKLLIGADGHNSGVRRAAGIQNVSWTYDQSAVVATLHLS------EATENNVAWQRFLPSGPIALLPLSDTLS 275
Cdd:pfam01494 143 GEEYTVRAKYLVGCDGGRSPVRKTLGIEFEGFEGVPFGSLDVLFDApdlsdpVERAFVHYLIYAPHSRGFMVGPWRSAGR 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 276 S---LVWSTSHDHAAELVSMDEEEFVDAINSAFwsdanHTDFVDsastmlryvvtlLKPTRVSArqlppsiakvdaksra 352
Cdd:pfam01494 223 EryyVQVPWDEEVEERPEEFTDEELKQRLRSIV-----GIDLAL------------VEILWKSI---------------- 269

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 353 lFPLGLGHAAEYVRPRVALIGDAAHRVHPLAGQGVNMGFGDISSLVRHLStAAFNGKdlGSMSHLTGYETDRQRHNTALL 432
Cdd:pfam01494 270 -WGVASRVATRYRKGRVFLAGDAAHIHPPTGGQGLNTAIQDAFNLAWKLA-AVLRGQ--AGESLLDTYSAERLPVAWAVV 345


                  ...
gi 1949697010 433 AAT 435
Cdd:pfam01494 346 DFA 348
 
Name Accession Description Interval E-value
COQ6 TIGR01989
ubiquinone biosynthesis monooxygenase COQ6; This model represents the monooxygenase ...
 56-471 0e+00

ubiquinone biosynthesis monooxygenase COQ6; This model represents the monooxygenase responsible for the 4-hydroxylateion of the phenol ring in the aerobic biosynthesis of ubiquinone


Pssm-ID: 273914 [Multi-domain]  Cd Length: 437  Bit Score: 636.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010  56 AAMACALGHDIHFRDKKILLLEAG--PKK---VLEKLSDTYSNRVSSISPGSATLLSSFGAWDHICNMRCKAFRRMQVWD 130
Cdd:TIGR01989  13 LALAAALGNNPLTKDLKVLLLDAVdnPKLksrNYEKPDGPYSNRVSSITPASISFFKKIGAWDHIQSDRIQPFGRMQVWD 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 131 SCSEALIMFDRDN-LDDMGYIVENDVIMCALTKQLEAV-ADRVRVLYRSKAVDYAWPAPfSMTDSSPWVHITLGDGSTLQ 208
Cdd:TIGR01989  93 GCSLALIRFDRDNgKEDMACIIENDNIQNSLYNRLQEYnGDNVKILNPARLISVTIPSK-YPNDNSNWVHITLSDGQVLY 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 209 TKLLIGADGHNSGVRRAAGIQNVSWTYDQSAVVATLHLSEATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHDHAAE 288
Cdd:TIGR01989 172 TKLLIGADGSNSNVRKAANIDTTGWNYNQHAVVATLKLEEATENDVAWQRFLPTGPIALLPLPDNNSTLVWSTSPEEALR 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 289 LVSMDEEEFVDAINSAF---WSDANHTDFVDSASTMLRYVVTLLKPTRVSARQLPPSIAKVDAKSRALFPLGLGHAAEYV 365
Cdd:TIGR01989 252 LLSLPPEDFVDALNAAFdlgYSDHPYSYLLDYAMEKLNEDIGFRTEGSKSCFQVPPRVIGVVDKSRAAFPLGLGHADEYV 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 366 RPRVALIGDAAHRVHPLAGQGVNMGFGDISSLVRHLSTAAFNGKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLYSTS 445
Cdd:TIGR01989 332 TKRVALVGDAAHRVHPLAGQGVNLGFGDVASLVKALAEAVSVGADIGSISSLKPYERERYAKNVVLLGLVDKLHKLYATD 411

                         410       420
                  ....*....|....*....|....*.
gi 1949697010 446 ATPLVLLRTWGLQATNAVSPLKEQIM 471
Cdd:TIGR01989 412 FPPVVALRTFGLNLTNYIGPLKNFIM 437
Ubi-OHases TIGR01988
Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a ...
 56-475 7.13e-152

Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; This model represents a family of FAD-dependent hydroxylases (monooxygenases) which are all believed to act in the aerobic ubiquinone biosynthesis pathway. A separate set of hydroxylases, as yet undiscovered, are believed to be active under anaerobic conditions. In E. coli three enzyme activities have been described, UbiB (which acts first at position 6, see TIGR01982), UbiH (which acts at position 4) and UbiF (which acts at position 5). UbiH and UbiF are similar to one another and form the basis of this subfamily. Interestingly, E. coli contains another hydroxylase gene, called visC, that is highly similar to UbiF, adjacent to UbiH and, when mutated, results in a phenotype similar to that of UbiH (which has also been named visB). Several other species appear to have three homologs in this family, although they assort themselves differently on phylogenetic trees (e.g. Xylella and Mesorhizobium) making it difficult to ascribe a specific activity to each one. Eukaryotes appear to have only a single homolog in this subfamily (COQ6) which complements UbiH, but also possess a non-orthologous gene, COQ7 which complements UbiF. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273913 [Multi-domain]  Cd Length: 385  Bit Score: 437.41  E-value: 7.13e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010  56 AAMACALGHDIhfrdKKILLLEAGPKKVLEklSDTYSNRVSSISPGSATLLSSFGAWDHICNMRCKAFRRMQVWDSCSEA 135
Cdd:TIGR01988  12 LALALALARSG----LKVALIEATPLPAPA--DPGFDNRVSALSAASIRLLEKLGVWDKIEPARAQPIRDIHVSDGGSFG 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 136 LIMFDRD--NLDDMGYIVENDVIMCALtkqLEAVADRVRVLYRSKAvdyawpAPFSMTDSSPWVHITLGDGSTLQTKLLI 213
Cdd:TIGR01988  86 ALRFDADeiGLEALGYVVENRVLQQAL---WERLQELPNVTLLCPA------RVVELPRHSDHVELTLDDGQQLRARLLV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 214 GADGHNSGVRRAAGIQNVSWTYDQSAVVATLHLSEATeNNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHDHAAELVSMD 293
Cdd:TIGR01988 157 GADGANSKVRQLAGIPTTGWDYGQSAVVANVKHERPH-QGTAWERFTPTGPLALLPLPDNRSSLVWTLPPEEAERLLALS 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 294 EEEFVDAINSAFWSDANhtdfvdsastmlryvvtllkptrvsarqlppsiAKVDAKSRALFPLGLGHAAEYVRPRVALIG 373
Cdd:TIGR01988 236 DEEFLAELQRAFGSRLG---------------------------------AITLVGERHAFPLSLTHAKRYVAPRLALIG 282

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 374 DAAHRVHPLAGQGVNMGFGDISSLVRHLSTAAFNGKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLYSTSATPLVLLR 453
Cdd:TIGR01988 283 DAAHTIHPLAGQGLNLGLRDVAALAEVLEDARRRGEDIGSLRVLQRYERRRRFDNAAMLGATDGLNRLFSNDFPPLRLLR 362

                         410       420
                  ....*....|....*....|..
gi 1949697010 454 TWGLQATNAVSPLKEQIMAFAS 475
Cdd:TIGR01988 363 NLGLRLLNNLPPLKNFIARYAM 384
PRK08850 PRK08850
2-octaprenyl-6-methoxyphenol hydroxylase; Validated
 70-474 2.52e-75

2-octaprenyl-6-methoxyphenol hydroxylase; Validated


Pssm-ID: 236341 [Multi-domain]  Cd Length: 405  Bit Score: 241.98  E-value: 2.52e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010  70 DKKILLLEAG-PKKVLEKLSDtysNRVSSISPGSATLLSSFGAWDHICNMRCKAFRRMQVWDSCSEALIMFDRDNL--DD 146
Cdd:PRK08850   27 DLRIAVIEGQlPEEALNELPD---VRVSALSRSSEHILRNLGAWQGIEARRAAPYIAMEVWEQDSFARIEFDAESMaqPD 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 147 MGYIVENDVIMCALTKQLEAvADRVRVLYRSKAvdyawpAPFSMTDSSPWvhITLGDGSTLQTKLLIGADGHNSGVRRAA 226
Cdd:PRK08850  104 LGHIVENRVIQLALLEQVQK-QDNVTLLMPARC------QSIAVGESEAW--LTLDNGQALTAKLVVGADGANSWLRRQM 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 227 GIQNVSWTYDQSAVVATLHLSEaTENNVAWQRFLPSGPIALLPLSDT-LSSLVWSTSHDHAAELVSMDEEEFVDAINSAF 305
Cdd:PRK08850  175 DIPLTHWDYGHSALVANVRTVD-PHNSVARQIFTPQGPLAFLPMSEPnMSSIVWSTEPLRAEALLAMSDEQFNKALTAEF 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 306 wsDAnhtdfvdsastmlryvvtllkptrvsarQLppSIAKVDAkSRALFPLGLGHAAEYVRPRVALIGDAAHRVHPLAGQ 385
Cdd:PRK08850  254 --DN----------------------------RL--GLCEVVG-ERQAFPLKMRYARDFVRERVALVGDAAHTIHPLAGQ 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 386 GVNMGFGDISSLVRHLSTAAFNGKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLYSTSATPLVLLRTWGLQATNAVSP 465
Cdd:PRK08850  301 GVNLGLLDAASLAQEILALWQQGRDIGLKRNLRGYERWRKAEAAKMIAAMQGFRDLFSGSNPAKKLVRGIGMSLAGQLPG 380


                  ....*....
gi 1949697010 466 LKEQIMAFA 474
Cdd:PRK08850  381 AKDEIMKRA 389
PRK07608 PRK07608
UbiH/UbiF family hydroxylase;
56-475 1.10e-68

UbiH/UbiF family hydroxylase;


Pssm-ID: 181057 [Multi-domain]  Cd Length: 388  Bit Score: 224.06  E-value: 1.10e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010  56 AAMACALGHdihfRDKKILLLEAGPkkVLEKLSDTYSNRVSSISPGSATLLSSFGAWDHICNMRCKAFRRMQVWDScSEA 135
Cdd:PRK07608   18 ASLALALAQ----SGLRVALLAPRA--PPRPADDAWDSRVYAISPSSQAFLERLGVWQALDAARLAPVYDMRVFGD-AHA 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 136 LIMFD--RDNLDDMGYIVENDVIMCALtkqleavadrVRVLYRSKAVDY--AWPAPFSMTDSSpwVHITLGDGSTLQTKL 211
Cdd:PRK07608   91 RLHFSayQAGVPQLAWIVESSLIERAL----------WAALRFQPNLTWfpARAQGLEVDPDA--ATLTLADGQVLRADL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 212 LIGADGHNSGVRRAAGIQNVSWTYDQSAVVATLhLSEATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHDHAAELVS 291
Cdd:PRK07608  159 VVGADGAHSWVRSQAGIKAERRPYRQTGVVANF-KAERPHRGTAYQWFRDDGILALLPLPDGHVSMVWSARTAHADELLA 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 292 MDEEEFVDAInsafwsdanhtdfvdsastmlryvvtllkpTRVSARQLppsiAKVDAKSRAL-FPLGLGHAAEYVRPRVA 370
Cdd:PRK07608  238 LSPEALAARV------------------------------ERASGGRL----GRLECVTPAAgFPLRLQRVDRLVAPRVA 283

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 371 LIGDAAHRVHPLAGQGVNMGFGDISSLVRHL-STAAFngKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLYSTSATPL 449
Cdd:PRK07608  284 LVGDAAHLIHPLAGQGMNLGLRDVAALADVLaGREPF--RDLGDLRLLRRYERARREDILALQVATDGLQRLFALPGPLA 361

                         410       420
                  ....*....|....*....|....*.
gi 1949697010 450 VLLRTWGLQATNAVSPLKEQIMAFAS 475
Cdd:PRK07608  362 RWLRNAGMALVGALPLVKRWLVRHAL 387
PRK07364 PRK07364
FAD-dependent hydroxylase;
56-467 1.41e-68

FAD-dependent hydroxylase;


Pssm-ID: 236001 [Multi-domain]  Cd Length: 415  Bit Score: 224.90  E-value: 1.41e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010  56 AAMACALghdihfRDK--KILLLEAGPKKVLEKLSDTYSnrvssISPGSATLLSSFGAWDHICNmRCKAFRRMQVWDSCS 133
Cdd:PRK07364   31 LTLAAAL------KDSglRIALIEAQPAEAAAAKGQAYA-----LSLLSARIFEGIGVWEKILP-QIGKFRQIRLSDADY 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 134 EALIMFDRDNL--DDMGYIVENDVIMCALTKQLEAvADRVRVLYRSKAVdyawpapfSMTDSSPWVHITL---GDGSTLQ 208
Cdd:PRK07364   99 PGVVKFQPTDLgtEALGYVGEHQVLLEALQEFLQS-CPNITWLCPAEVV--------SVEYQQDAATVTLeieGKQQTLQ 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 209 TKLLIGADGHNSGVRRAAGIQNVSWTYDQSAVVATLHLsEATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHDHAAE 288
Cdd:PRK07364  170 SKLVVAADGARSPIRQAAGIKTKGWKYWQSCVTATVKH-EAPHNDIAYERFWPSGPFAILPLPGNRCQIVWTAPHAQAKA 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 289 LVSMDEEEFVDainsafwsdanhtdfvdsasTMLRYVVTLL-KPTRVSARQlppsiakvdaksraLFPLGLGHAAEYVRP 367
Cdd:PRK07364  249 LLALPEAEFLA--------------------ELQQRYGDQLgKLELLGDRF--------------LFPVQLMQSDRYVQH 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 368 RVALIGDAAHRVHPLAGQGVNMGFGDISSLVRHLSTAAFNGKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLYSTSAT 447
Cdd:PRK07364  295 RLALVGDAAHCCHPVGGQGLNLGIRDAAALAQVLQTAHQRGEDIGSLAVLKRYERWRKRENWLILGFTDLLDRLFSNQWW 374

                         410       420
                  ....*....|....*....|
gi 1949697010 448 PLVLLRTWGLQATNAVSPLK 467
Cdd:PRK07364  375 PLVVVRRLGLWLLRHVPPLK 394
ubiF PRK08020
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed
 94-474 9.67e-66

2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed


Pssm-ID: 181199 [Multi-domain]  Cd Length: 391  Bit Score: 216.77  E-value: 9.67e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010  94 RVSSISPGSATLLSSFGAWDHICNMRCKAFRRMQVWDSCSeALIMFDRD--NLDDMGYIVENDVIMCALTKQLEAvADRV 171
Cdd:PRK08020   51 RISAISAASVALLKGLGVWDAVQAMRSHPYRRLETWEWET-AHVVFDAAelKLPELGYMVENRVLQLALWQALEA-HPNV 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 172 RVLyrskavdyawpAPFSMTDSSP----WvHITLGDGSTLQTKLLIGADGHNSGVRRAAGIQNVSWTYDQSAVVATLHlS 247
Cdd:PRK08020  129 TLR-----------CPASLQALQRdddgW-ELTLADGEEIQAKLVIGADGANSQVRQMAGIGVHGWQYRQSCMLISVK-C 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 248 EATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHDHAAELVSMDEEEFVDAINSAFwsdanhtdfvdsastmlryvvt 327
Cdd:PRK08020  196 ENPPGDSTWQQFTPSGPRAFLPLFDNWASLVWYDSPARIRQLQAMSMAQLQQEIAAHF---------------------- 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 328 llkPTRvsarqlppsIAKVDAKSRALFPLGLGHAAEYVRPRVALIGDAAHRVHPLAGQGVNMGFGDISSLVRHLSTAAFN 407
Cdd:PRK08020  254 ---PAR---------LGAVTPVAAGAFPLTRRHALQYVQPGLALVGDAAHTINPLAGQGVNLGYRDVDALLDVLVNARSY 321

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1949697010 408 GKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLYSTSATPLVLLRTWGLQATNAVSPLKEQIMAFA 474
Cdd:PRK08020  322 GEAWASEAVLKRYQRRRMADNLLMQSGMDLFYAGFSNNLPPLRFARNLGLMAAQRAGVLKRQALKYA 388
UbiH TIGR01984
2-polyprenyl-6-methoxyphenol 4-hydroxylase; This model represents the FAD-dependent ...
 56-470 2.40e-64

2-polyprenyl-6-methoxyphenol 4-hydroxylase; This model represents the FAD-dependent monoxygenase responsible for the second hydroxylation step in the aerobic ubiquinone bioynthetic pathway. The scope of this model is limited to the proteobacteria. This family is closely related to the UbiF hydroxylase which catalyzes the final hydroxylation step. The enzyme has also been named VisB due to a mutant VISible light sensitive phenotype. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273911 [Multi-domain]  Cd Length: 382  Bit Score: 212.56  E-value: 2.40e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010  56 AAMACALGHDihfRDKKILLLEAGPKKVLEKLSDtysNRVSSISPGSATLLSSFGAWDHICNMRCkAFRRMQVWDSCSEA 135
Cdd:TIGR01984  12 LSLALALSRL---GKIKIALIEANSPSAAQPGFD---ARSLALSYGSKQILEKLGLWPKLAPFAT-PILDIHVSDQGHFG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 136 LIMFDRD--NLDDMGYIVENDVIMCALTKQLEavadrvrvlyRSKAVDYAWPAPFSMTDSSP-WVHITLGDGSTLQTKLL 212
Cdd:TIGR01984  85 ATHLRASefGLPALGYVVELADLGQALLSRLA----------LLTNIQLYCPARYKEIIRNQdYVRVTLDNGQQLRAKLL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 213 IGADGHNSGVRRAAGIQNVSWTYDQSAVVATLHLSEATENnVAWQRFLPSGPIALLPLSD-TLSSLVWSTSHDHAAELVS 291
Cdd:TIGR01984 155 IAADGANSKVRELLSIPTEEHDYNQTALIANIRHEQPHQG-CAFERFTPHGPLALLPLKDnYRSSLVWCLPSKQADTIAN 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 292 MDEEEFVDAINSAFWSDANhtdfvdsastmlryvvtllKPTRVSARQLppsiakvdaksralFPLGLGHAAEYVRPRVAL 371
Cdd:TIGR01984 234 LPDAEFLAELQQAFGWRLG-------------------KITQVGERKT--------------YPLKLRIAETHVHPRVVL 280

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 372 IGDAAHRVHPLAGQGVNMGFGDISSLVRHLSTAAfngKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLYSTSATPLVL 451
Cdd:TIGR01984 281 IGNAAQTLHPIAGQGFNLGLRDVETLAEVLIDAR---IDLGTYALLQEYLRRRQFDQFITIGLTDGLNRLFSNHIPLLRA 357

                         410
                  ....*....|....*....
gi 1949697010 452 LRTWGLQATNAVSPLKEQI 470
Cdd:TIGR01984 358 LRNLGLLALENFPPLKKRL 376
PRK07333 PRK07333
ubiquinone biosynthesis hydroxylase;
70-468 1.11e-62

ubiquinone biosynthesis hydroxylase;


Pssm-ID: 180935 [Multi-domain]  Cd Length: 403  Bit Score: 209.07  E-value: 1.11e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010  70 DKKILLLEAGPKKVLEKlsdtySNRVSSISPGSATLLSSFGAWDHICNmRCKAFRRMQVWDSCSE-----ALIMFDRDNL 144
Cdd:PRK07333   26 HLPVTVVDAAPAGAWSR-----DPRASAIAAAARRMLEALGVWDEIAP-EAQPITDMVITDSRTSdpvrpVFLTFEGEVE 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 145 DD--MGYIVENDVIMCALTKQLEAVAdrVRVLYRSKAVDyawpapFSMTDSSpwVHITLGDGSTLQTKLLIGADGHNSGV 222
Cdd:PRK07333  100 PGepFAHMVENRVLINALRKRAEALG--IDLREATSVTD------FETRDEG--VTVTLSDGSVLEARLLVAADGARSKL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 223 RRAAGIQNVSWTYDQSAVVATL-HlsEATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHDHAAELVSMDEEEFVDAI 301
Cdd:PRK07333  170 RELAGIKTVGWDYGQSGIVCTVeH--ERPHGGRAEEHFLPAGPFAILPLKGNRSSLVWTERTADAERLVALDDLVFEAEL 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 302 NSAFWsdanhtdfvdsastmlryvvtlLKPTRVsarqlppsiaKVDAKSRAlFPLGLGHAAEYVRPRVALIGDAAHRVHP 381
Cdd:PRK07333  248 EQRFG----------------------HRLGEL----------KVLGKRRA-FPLGLTLARSFVAPRFALVGDAAHGIHP 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 382 LAGQGVNMGFGDISSLVRHLSTAAFNGKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLYSTSATPLVLLRTWGLQATN 461
Cdd:PRK07333  295 IAGQGLNLGLKDVAALAEVVVEAARLGLDIGSLDVLERYQRWRRFDTVRMGVTTDVLNRLFSNDSTLLRSVRDIGLGLVD 374


                  ....*..
gi 1949697010 462 AVSPLKE 468
Cdd:PRK07333  375 RLPKLKS 381
PRK05714 PRK05714
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional
 56-467 2.85e-62

2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional


Pssm-ID: 168201 [Multi-domain]  Cd Length: 405  Bit Score: 208.14  E-value: 2.85e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010  56 AAMACALGHDihfrDKKILLLEAGPKKVLEKLSDT-YSNRVSSISPGSATLLSSFGAWDHICNMRCKAFRRMQVWDSCSE 134
Cdd:PRK05714   15 SALALALQGS----GLEVLLLDGGPLSVKPFDPQApFEPRVSALSAASQRILERLGAWDGIAARRASPYSEMQVWDGSGT 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 135 ALIMFDRDNL--DDMGYIVENDVIMCALtkqLEAVAD---------RVRVLYRSkavdyawpapfsmtdSSPWVhITLGD 203
Cdd:PRK05714   91 GQIHFSAASVhaEVLGHIVENRVVQDAL---LERLHDsdigllanaRLEQMRRS---------------GDDWL-LTLAD 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 204 GSTLQTKLLIGADGHNSGVRRAAGIQNVSWTYDQSAVVATLHLSEAtENNVAWQRFLPSGPIALLPLSDT----LSSLVW 279
Cdd:PRK05714  152 GRQLRAPLVVAADGANSAVRRLAGCATREWDYLHHAIVTSVRCSEP-HRATAWQRFTDDGPLAFLPLERDgdehWCSIVW 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 280 STSHDHAAELVSMDEEEFVDAINSAFWSDANHTdfvdsastmlryvvtllkptrvsarqlppsiakVDAKSRALFPLGLG 359
Cdd:PRK05714  231 STTPEEAERLMALDDDAFCAALERAFEGRLGEV---------------------------------LSADPRLCVPLRQR 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 360 HAAEYVRPRVALIGDAAHRVHPLAGQGVNMGFGDISSLVRHLSTAAFNGKDLGSMSHLTGYETDRQRHNTALLAATDLLK 439
Cdd:PRK05714  278 HAKRYVEPGLALIGDAAHTIHPLAGQGVNLGFLDAAVLAEVLLHAAERGERLADVRVLSRFERRRMPHNLALMAAMEGFE 357

                         410       420
                  ....*....|....*....|....*...
gi 1949697010 440 RLYSTSATPLVLLRTWGLQATNAVSPLK 467
Cdd:PRK05714  358 RLFQADPLPLRWLRNTGLKLVDQMPEAK 385
PRK08849 PRK08849
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional
 71-474 6.99e-61

2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional


Pssm-ID: 181564 [Multi-domain]  Cd Length: 384  Bit Score: 203.85  E-value: 6.99e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010  71 KKILLLEAGPKKVLEKlSDTYSNRVSSISPGSATLLSSFGAWDHICNMRCKAFRRMQVWDScSEALIMFDRD--NLDDMG 148
Cdd:PRK08849   27 RSVAVIEGGEPKAFEP-SQPMDIRVSAISQTSVDLLESLGAWSSIVAMRVCPYKRLETWEH-PECRTRFHSDelNLDQLG 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 149 YIVENDVIMCALTKQLEAVaDRVRVLyrskavdyawpAPFSMTD---SSPWVHITLGDGSTLQTKLLIGADGHNSGVRRA 225
Cdd:PRK08849  105 YIVENRLIQLGLWQQFAQY-PNLTLM-----------CPEKLADlefSAEGNRVTLESGAEIEAKWVIGADGANSQVRQL 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 226 AGIQNVSWTYDQSAVVATLHlSEATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHDHAAELVSMDEEEFVDAInsaf 305
Cdd:PRK08849  173 AGIGITAWDYRQHCMLINVE-TEQPQQDITWQQFTPSGPRSFLPLCGNQGSLVWYDSPKRIKQLSAMNPEQLRSEI---- 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 306 wsdanhtdfvdsastmlryvvtllkptrvsARQLPPSIAKVDAKSRALFPLGLGHAAEYVRPRVALIGDAAHRVHPLAGQ 385
Cdd:PRK08849  248 ------------------------------LRHFPAELGEIKVLQHGSFPLTRRHAQQYVKNNCVLLGDAAHTINPLAGQ 297

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 386 GVNMGFGDISSLVrhlstAAFNGKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLYSTSATPLVLLRTWGLQATNAVSP 465
Cdd:PRK08849  298 GVNLGFKDVDVLL-----AETEKQGVLNDASFARYERRRRPDNLLMQTGMDLFYKTFSNSLTPLKFVRNAALKLAENSGP 372


                  ....*....
gi 1949697010 466 LKEQIMAFA 474
Cdd:PRK08849  373 LKTQVLKYA 381
PRK08013 PRK08013
oxidoreductase; Provisional
 83-471 3.26e-58

oxidoreductase; Provisional


Pssm-ID: 236139 [Multi-domain]  Cd Length: 400  Bit Score: 197.19  E-value: 3.26e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010  83 VLEK-------LSDTYSNRVSSISPGSATLLSSFGAWDHICNMRCKAFRRMQVWDSCSEALIMFDRDN--LDDMGYIVEN 153
Cdd:PRK08013   31 VLEQrvpeplaADAPPALRVSAINAASEKLLTRLGVWQDILARRASCYHGMEVWDKDSFGRIAFDDQSmgYSHLGHIIEN 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 154 DVIMCALTKQLEAVADrVRVLYRSKAVDYAWpapfsmtdSSPWVHITLGDGSTLQTKLLIGADGHNSGVRRAAGIQNVSW 233
Cdd:PRK08013  111 SVIHYALWQKAQQSSD-ITLLAPAELQQVAW--------GENEAFLTLKDGSMLTARLVVGADGANSWLRNKADIPLTFW 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 234 TYDQSAVVATLHlSEATENNVAWQRFLPSGPIALLPLSD-TLSSLVWSTSHDHAAELVSMDEEEFVDAINSAFwsdanht 312
Cdd:PRK08013  182 DYQHHALVATIR-TEEPHDAVARQVFHGDGILAFLPLSDpHLCSIVWSLSPEEAQRMQQAPEEEFNRALAIAF------- 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 313 dfvdsastmlryvvtllkPTRVSARQLppsiakvdAKSRALFPLGLGHAAEYVRPRVALIGDAAHRVHPLAGQGVNMGFG 392
Cdd:PRK08013  254 ------------------DNRLGLCEL--------ESERQVFPLTGRYARQFAAHRLALVGDAAHTIHPLAGQGVNLGFM 307

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1949697010 393 DISSLVRHLSTAAFNGKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLYSTSATPLVLLRTWGLQATNAVSPLKEQIM 471
Cdd:PRK08013  308 DAAELIAELRRLHRQGKDIGQHLYLRRYERSRKHSAALMLAGMQGFRDLFAGNNPAKKLLRDIGLKLADTLPGVKPQLI 386
PRK08773 PRK08773
UbiH/UbiF family hydroxylase;
94-466 2.43e-55

UbiH/UbiF family hydroxylase;


Pssm-ID: 181552 [Multi-domain]  Cd Length: 392  Bit Score: 189.30  E-value: 2.43e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010  94 RVSSISPGSATLLSSFGAWDHICNMRCKAFRRMQVWDSCSEALIMFDRDNL--DDMGYIVENDVIMCALTKQLEAVADRV 171
Cdd:PRK08773   51 RVYAFAADNAALLDRLGVWPAVRAARAQPYRRMRVWDAGGGGELGFDADTLgrEQLGWIVENDLLVDRLWAALHAAGVQL 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 172 RVLYRSKAVDyawpapfsmtDSSPWVHITLGDGSTLQTKLLIGADGHNSGVRRAAGIQNVSWTYDQSAVVA---TLHLSE 248
Cdd:PRK08773  131 HCPARVVALE----------QDADRVRLRLDDGRRLEAALAIAADGAASTLRELAGLPVSRHDYAQRGVVAfvdTEHPHQ 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 249 ATennvAWQRFLPSGPIALLPLSDTLSSLVWSTSHDHAAELVSMDEEEFVDAINSAFwsdanhtdfvdsastmlryvvtl 328
Cdd:PRK08773  201 AT----AWQRFLPTGPLALLPFADGRSSIVWTLPDAEAERVLALDEAAFSRELTQAF----------------------- 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 329 lkPTRVSARQLppsiakvdAKSRALFPLGLGHAAEYVRPRVALIGDAAHRVHPLAGQGVNMGFGDISSLVRHLSTAAFNG 408
Cdd:PRK08773  254 --AARLGEVRV--------ASPRTAFPLRRQLVQQYVSGRVLTLGDAAHVVHPLAGQGVNLGLRDVAALQQLVRQAHARR 323

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1949697010 409 KDLGSMSHLTGYETDRQRHNTALLAATDLLKRLYSTSATPLVLLRTWGLQATNAVSPL 466
Cdd:PRK08773  324 ADWAAPHRLQRWARTRRSDNTVAAYGFDAINRVFSNDEMHLTLLRGSVLGLAGKLPPL 381
PRK05732 PRK05732
2-octaprenyl-6-methoxyphenyl hydroxylase; Validated
 56-467 1.63e-51

2-octaprenyl-6-methoxyphenyl hydroxylase; Validated


Pssm-ID: 235584 [Multi-domain]  Cd Length: 395  Bit Score: 179.28  E-value: 1.63e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010  56 AAMACALGHDIHfRDKKILLLEAgpKKVLEKLSDTYSNRVSSISPGSATLLSSFGAWDHIcNMRCKAFRRMQVWDS--CS 133
Cdd:PRK05732   16 ATLALALSRLSH-GGLPVALIEA--FAPESDAHPGFDARAIALAAGTCQQLARLGVWQAL-ADCATPITHIHVSDRghAG 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 134 EALIMFDRDNLDDMGYIVENDVIMCALTKQLEAvADRVRvLYRSKAVDyawpapfSMTDSSPWVHITLGDGSTLQTKLLI 213
Cdd:PRK05732   92 FVRLDAEDYGVPALGYVVELHDVGQRLFALLDK-APGVT-LHCPARVA-------NVERTQGSVRVTLDDGETLTGRLLV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 214 GADGHNSGVRRAAGIQNVSWTYDQSAVVATLHLSEAtENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHDHAAELVSMD 293
Cdd:PRK05732  163 AADGSHSALREALGIDWQQHPYEQVAVIANVTTSEA-HQGRAFERFTEHGPLALLPMSDGRCSLVWCHPLEDAEEVLSWS 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 294 EEEFVDAINSAF-WSdanhtdfvdsastmlryvvtLLKPTRVSArqlppsiakvdaksRALFPLGLGHAAEYVRPRVALI 372
Cdd:PRK05732  242 DAQFLAELQQAFgWR--------------------LGRITHAGK--------------RSAYPLALVTAAQQISHRLALV 287

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 373 GDAAHRVHPLAGQGVNMGFGDISSLVRHLSTAAFNGKDLGSMSHLTGYETDRQ--RHNTalLAATDLLKRLYSTSATPLV 450
Cdd:PRK05732  288 GNAAQTLHPIAGQGFNLGLRDVMSLAETLTQALARGEDIGDYAVLQRYQQRRQqdREAT--IGFTDGLVRLFANRWAPLV 365

                         410
                  ....*....|....*..
gi 1949697010 451 LLRTWGLQATNAVSPLK 467
Cdd:PRK05732  366 VGRNLGLMAMDLLPPAR 382
PRK09126 PRK09126
FAD-dependent hydroxylase;
72-470 1.49e-44

FAD-dependent hydroxylase;


Pssm-ID: 236385 [Multi-domain]  Cd Length: 392  Bit Score: 160.49  E-value: 1.49e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010  72 KILLLEAGPKKVLEklSDTYSNRVSSISPGSATLLSSFGAWDHICNMRCKAFRRMQVWDSCSEALIMFDRDN--LDDMGY 149
Cdd:PRK09126   28 KVTLIERQPLAALA--DPAFDGREIALTHASREILQRLGAWDRIPEDEISPLRDAKVLNGRSPFALTFDARGrgADALGY 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 150 IVENDVIMCALtkqLEAVADRVRV-LYRSKAVDyawpapfSMTDSSPWVHITLGDGSTLQTKLLIGADGHNSGVRRAAGI 228
Cdd:PRK09126  106 LVPNHLIRRAA---YEAVSQQDGIeLLTGTRVT-------AVRTDDDGAQVTLANGRRLTARLLVAADSRFSATRRQLGI 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 229 QNVSWTYDQSAVVATLHlSEATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHDHAAELVSMDEEEFVDAINSAFwsd 308
Cdd:PRK09126  176 GADMHDFGRTMLVCRMR-HELPHHHTAWEWFGYGQTLALLPLNGHLSSLVLTLPPDQIEALLALDPEAFAAEVTARF--- 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 309 aNHtdfvdsastmlryvvtllkptRVSARQLppsiakvdAKSRALFPLGLGHAAEYVRPRVALIGDAAHRVHPLAGQGVN 388
Cdd:PRK09126  252 -KG---------------------RLGAMRL--------VSSRHAYPLVAVYAHRFVAKRFALIGDAAVGMHPVTAHGFN 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 389 MGFGDISSLVRHLSTAAFNGKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLYSTSATPLVLLRTWGLQATNAVSPLKE 468
Cdd:PRK09126  302 LGLKGQDILARLILAAARRGQDIGAASLLERYERKHRLATRPLYHATNAIAALYTDDRPPARLLRRAVLRAANRFPPLKQ 381


                  ..
gi 1949697010 469 QI 470
Cdd:PRK09126  382 AI 383
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 56-467 4.19e-39

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 144.31  E-value: 4.19e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010  56 AAMACAL---GHDIHfrdkkillleagpkkVLEKLSDTYSN-RVSSISPGSATLLSSFGAWDHICnMRCKAFRRMQVWDS 131
Cdd:COG0654    16 LALALALaraGIRVT---------------VVERAPPPRPDgRGIALSPRSLELLRRLGLWDRLL-ARGAPIRGIRVRDG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 132 CS-EALIMFDRDNLD-DMGYIVENDVIMCALTKQLEAvaDRVRVLYRSKAVDYAWpapfsmTDSSpwVHITLGDGSTLQT 209
Cdd:COG0654    80 SDgRVLARFDAAETGlPAGLVVPRADLERALLEAARA--LGVELRFGTEVTGLEQ------DADG--VTVTLADGRTLRA 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 210 KLLIGADGHNSGVRRAAGIQNVSWTYDQSAVVATLHLseatennvawqrflpsgpiallplsdtlsslvwstshdhaael 289
Cdd:COG0654   150 DLVVGADGARSAVRRLLGIGFTGRDYPQRALWAGVRT------------------------------------------- 186

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 290 vsmdeeEFVDAINSAFWsdanhtdfvdsastmlryvvtllkptrvSARQLppsiakVDAKSRALFPLGLGHAAEYVRPRV 369
Cdd:COG0654   187 ------ELRARLAAAGP----------------------------RLGEL------LELSPRSAFPLRRRRAERWRRGRV 226

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 370 ALIGDAAHRVHPLAGQGVNMGFGDISSLVRHLStAAFNGKDLGSMshLTGYETDRQRHNTALLAATDLLKRLYSTSATPL 449
Cdd:COG0654   227 VLLGDAAHTMHPLGGQGANLALRDAAALAWKLA-AALRGRDDEAA--LARYERERRPRAARVQRAADALGRLFHPDSPPL 303

                         410
                  ....*....|....*...
gi 1949697010 450 VLLRTWGLQATNAVSPLK 467
Cdd:COG0654   304 RLLRNAGLRLLDRLPPLK 321
PRK07494 PRK07494
UbiH/UbiF family hydroxylase;
197-471 1.19e-37

UbiH/UbiF family hydroxylase;


Pssm-ID: 181001 [Multi-domain]  Cd Length: 388  Bit Score: 141.58  E-value: 1.19e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 197 VHITLGDGSTLQTKLLIGADGHNSGVRRAAGIQNVSWTYDQSAVV-ATLHlsEATENNVAWQRFLPSGPIALLPLSDTLS 275
Cdd:PRK07494  144 VTVTLADGTTLSARLVVGADGRNSPVREAAGIGVRTWSYPQKALVlNFTH--SRPHQNVSTEFHTEGGPFTQVPLPGRRS 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 276 SLVWSTSHDHAAELVSMDEEEFVDAINSafwsdanhtdfvDSAStmlryvvtLLKPTRVSARqlppsiakvdaksRALFP 355
Cdd:PRK07494  222 SLVWVVRPAEAERLLALSDAALSAAIEE------------RMQS--------MLGKLTLEPG-------------RQAWP 268

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 356 LGLGHAAEYVRPRVALIGDAAHRVHPLAGQGVNMGFGDISSLVRHLSTaafNGKDLGSMSHLTGYetDRQRHNTALL--A 433
Cdd:PRK07494  269 LSGQVAHRFAAGRTALVGEAAHVFPPIGAQGLNLGLRDVATLVEIVED---RPEDPGSAAVLAAY--DRARRPDILSrtA 343

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1949697010 434 ATDLLKRLYSTSATPLVLLRTWGLQATNAVSPLKEQIM 471
Cdd:PRK07494  344 SVDLLNRSLLSDFLPVQDLRAAGLHLLYSFGPLRRLFM 381
PRK06996 PRK06996
UbiH/UbiF/VisC/COQ6 family ubiquinone biosynthesis hydroxylase;
57-470 1.72e-35

UbiH/UbiF/VisC/COQ6 family ubiquinone biosynthesis hydroxylase;


Pssm-ID: 235905 [Multi-domain]  Cd Length: 398  Bit Score: 135.97  E-value: 1.72e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010  57 AMACALGHDIHFRDKKILLLEAGpkkvlEKLSDTYSNRVSSISPGSATLLSSFGAWDhicnMRCKAFRRMQVWDSCSEAL 136
Cdd:PRK06996   25 ALAGWLARRSATRALSIALIDAR-----EPAASANDPRAIALSHGSRVLLETLGAWP----ADATPIEHIHVSQRGHFGR 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 137 IMFDRDNLD--DMGYIVENDVIMCALTkqlEAVAD-RVRVLYRSKAvdyawPAPFSMTDSSPWVHITLGDGSTLQTKLLI 213
Cdd:PRK06996   96 TLIDRDDHDvpALGYVVRYGSLVAALA---RAVRGtPVRWLTSTTA-----HAPAQDADGVTLALGTPQGARTLRARIAV 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 214 GADGH-NSGVRRAAGIQNVSWTYDQSAVVATLHLSeATENNVAWQRFLPSGPIALLPLSDTLS---SLVWSTSHDHAAEL 289
Cdd:PRK06996  168 QAEGGlFHDQKADAGDSARRRDYGQTAIVGTVTVS-APRPGWAWERFTHEGPLALLPLGGPRQadyALVWCCAPDEAARR 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 290 VSMDEEEFVDAINSAFwsdanhtdfvdsASTMLRYVVtllkptrvsarqlppsiakvdAKSRALFPLGLGHAAEYVRPRV 369
Cdd:PRK06996  247 AALPDDAFLAELGAAF------------GTRMGRFTR---------------------IAGRHAFPLGLNAARTLVNGRI 293

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 370 ALIGDAAHRVHPLAGQGVNMGFGDISSLVRHLSTAAFNGKDLGSMSHltgyetdRQRHNTALLA-ATDLLKRLYSTSATP 448
Cdd:PRK06996  294 AAVGNAAQTLHPVAGQGLNLGLRDAHTLADALSDHGATPLALATFAA-------RRALDRRVTIgATDLLPRLFTVDSRP 366

                         410       420
                  ....*....|....*....|..
gi 1949697010 449 LVLLRTWGLQATNAVSPLKEQI 470
Cdd:PRK06996  367 LAHLRGAALTALEFVPPLKHAL 388
PRK06617 PRK06617
2-octaprenyl-6-methoxyphenyl hydroxylase; Validated
 72-474 2.53e-30

2-octaprenyl-6-methoxyphenyl hydroxylase; Validated


Pssm-ID: 168629 [Multi-domain]  Cd Length: 374  Bit Score: 121.18  E-value: 2.53e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010  72 KILLLEAGPKKVLEKLSDTysnRVSSISPGSATLLSSFGAWDHICNMRCKaFRRMQVWDSCSEALIMFDRDNLDDMGYIV 151
Cdd:PRK06617   26 KTTIFESKSVKSPEFFKDI---RTTALTPHSKNFLFSIDIWEELEKFVAE-MQDIYVVDNKASEILDLRNDADAVLGYVV 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 152 END----VIMCALTKQ-LEAVADrvrvlyrskavDYAWPAPFSMTDSSpwvhITLGDGSTLQTKLLIGADGHNSGVRRAA 226
Cdd:PRK06617  102 KNSdfkkILLSKITNNpLITLID-----------NNQYQEVISHNDYS----IIKFDDKQIKCNLLIICDGANSKVRSHY 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 227 GIQNVSWTYDQSAVVATLHlsEATENNVAWQRFLPSGPIALLPLSDTL-SSLVWSTSHDHAAELVSMDEEEfvdainsaf 305
Cdd:PRK06617  167 FANEIEKPYQTALTFNIKH--EKPHENCAMEHFLPLGPFALLPLKDQYaSSVIWSTSSDQAALIVNLPVEE--------- 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 306 wsdanhtdfvdsastmLRYVvtllkptrvSARQLPPSIAKVDAKSR-ALFPLGLGHAAEYVRPRVALIGDAAHRVHPLAG 384
Cdd:PRK06617  236 ----------------VRFL---------TQRNAGNSLGKITIDSEiSSFPLKARIANRYFHNRIVLIADTAHTVHPLAG 290

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 385 QGVNMGFGDISSLVRHLSTaafNGKdlgsmshLTGYETDRQRHNTALLAATDLLKRLYSTSATPLVLLRTWGLQATNAVS 464
Cdd:PRK06617  291 QGLNQGIKDIEILSMIVSN---NGT-------LQEYQKLRQEDNFIMYKLTDELNNIFSNYSKNLRCLRQIGFKVINNFK 360

                         410
                  ....*....|
gi 1949697010 465 PLKEQIMAFA 474
Cdd:PRK06617  361 PIKNLITSYA 370
PRK06834 PRK06834
hypothetical protein; Provisional
 197-393 1.83e-10

hypothetical protein; Provisional


Pssm-ID: 235870 [Multi-domain]  Cd Length: 488  Bit Score: 62.73  E-value: 1.83e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 197 VHITLGDGSTLQTKLLIGADGHNSGVRRAAGIQNVSWTYDQSAVVATLHLSEATENNV--------AWQRFLPSGPIAll 268
Cdd:PRK06834  133 VDVELSDGRTLRAQYLVGCDGGRSLVRKAAGIDFPGWDPTTSYLIAEVEMTEEPEWGVhrdalgihAFGRLEDEGPVR-- 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 269 plsdtlssLVWSTSHDHAAELVSMDeeEFVDAINSAFwsdanHTDF-VDSASTMLRYVVTllkptrvsARQlppsiakvd 347
Cdd:PRK06834  211 --------VMVTEKQVGATGEPTLD--DLREALIAVY-----GTDYgIHSPTWISRFTDM--------ARQ--------- 258

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1949697010 348 aksralfplglghAAEYVRPRVALIGDAAHRVHPLAGQGVNMGFGD 393
Cdd:PRK06834  259 -------------AASYRDGRVLLAGDAAHVHSPVGGQGLNTGVQD 291
FAD_binding_3 pfam01494
FAD binding domain; This domain is involved in FAD binding in a number of enzymes.
 202-435 6.91e-10

FAD binding domain; This domain is involved in FAD binding in a number of enzymes.


Pssm-ID: 396193 [Multi-domain]  Cd Length: 348  Bit Score: 60.42  E-value: 6.91e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 202 GDGSTLQTKLLIGADGHNSGVRRAAGIQNVSWTYDQSAVVATLHLS------EATENNVAWQRFLPSGPIALLPLSDTLS 275
Cdd:pfam01494 143 GEEYTVRAKYLVGCDGGRSPVRKTLGIEFEGFEGVPFGSLDVLFDApdlsdpVERAFVHYLIYAPHSRGFMVGPWRSAGR 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 276 S---LVWSTSHDHAAELVSMDEEEFVDAINSAFwsdanHTDFVDsastmlryvvtlLKPTRVSArqlppsiakvdaksra 352
Cdd:pfam01494 223 EryyVQVPWDEEVEERPEEFTDEELKQRLRSIV-----GIDLAL------------VEILWKSI---------------- 269

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 353 lFPLGLGHAAEYVRPRVALIGDAAHRVHPLAGQGVNMGFGDISSLVRHLStAAFNGKdlGSMSHLTGYETDRQRHNTALL 432
Cdd:pfam01494 270 -WGVASRVATRYRKGRVFLAGDAAHIHPPTGGQGLNTAIQDAFNLAWKLA-AVLRGQ--AGESLLDTYSAERLPVAWAVV 345


                  ...
gi 1949697010 433 AAT 435
Cdd:pfam01494 346 DFA 348
PRK07045 PRK07045
putative monooxygenase; Reviewed
 199-433 2.78e-08

putative monooxygenase; Reviewed


Pssm-ID: 136171 [Multi-domain]  Cd Length: 388  Bit Score: 55.68  E-value: 2.78e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 199 ITLGDGSTLQTKLLIGADGHNSGVRR-AAGIQNVSWTYDQSAVVATLHLSEATENNVAWQRFLPSGPIALLPLSDTLSSL 277
Cdd:PRK07045  144 VTLSDGERVAPTVLVGADGARSMIRDdVLRMPAERVPYATPMAFGTIALTDSVRECNRLYVDSNQGLAYFYPIGDQATRL 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 278 VWSTSHDHAAELVSMDEEEFVDAINSAFWSDanhtdfvDSASTMlryvvtllkptrvsarqlppsiAKVDAKSR-ALFPL 356
Cdd:PRK07045  224 VVSFPADEMQGYLADTTRTKLLARLNEFVGD-------ESADAM----------------------AAIGAGTAfPLIPL 274

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1949697010 357 GLGHAAEYVRPRVALIGDAAHRVHPLAGQGVNMGFGDISSLVRHLSTAAFNGKDLGSMshLTGYETDRQRHNTALLA 433
Cdd:PRK07045  275 GRMNLDRYHKRNVVLLGDAAHSIHPITGQGMNLAIEDAGELGACLDLHLSGQIALADA--LERFERIRRPVNEAVIS 349
PRK06184 PRK06184
hypothetical protein; Provisional
 202-393 2.06e-06

hypothetical protein; Provisional


Pssm-ID: 235728 [Multi-domain]  Cd Length: 502  Bit Score: 49.98  E-value: 2.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 202 GDGSTLQTKLLIGADGHNSGVRRAAGIQNVSWTYDQS-AVVATLHLSEATENnvAWQRFLPS--GPIALLPLSDTLSSLV 278
Cdd:PRK06184  150 AGEETVRARYLVGADGGRSFVRKALGIGFPGETLGIDrMLVADVSLTGLDRD--AWHQWPDGdmGMIALCPLPGTDLFQI 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 279 wstshdhAAELvsmDEEEFVDAinsafwSDANHTDFVDSASTMLRYVVTllKPTRVSARQlpPSIAKVDAksralfplgl 358
Cdd:PRK06184  228 -------QAPL---PPGGEPDL------SADGLTALLAERTGRTDIRLH--SVTWASAFR--MNARLADR---------- 277

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1949697010 359 ghaaeYVRPRVALIGDAAHrVHPLAG-QGVNMGFGD 393
Cdd:PRK06184  278 -----YRVGRVFLAGDAAH-VHPPAGgQGLNTSVQD 307
PRK08244 PRK08244
monooxygenase;
205-473 3.14e-06

monooxygenase;


Pssm-ID: 236199 [Multi-domain]  Cd Length: 493  Bit Score: 49.36  E-value: 3.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 205 STLQTKLLIGADGHNSGVRRAAGIQNVSWTYDQSAVVATLHLSEATENNVAwQRFLPSGPIALLPLSDTLSSLVWSTSHD 284
Cdd:PRK08244  144 RTLTSSYVVGADGAGSIVRKQAGIAFPGTDATFTAMLGDVVLKDPPPSSVL-SLCTREGGVMIVPLSGGIYRVLIIDPER 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 285 HAA---ELVSmdEEEFVDAInsafwSDANHTDF-VDSASTMLRYVVTllkptrvsARQlppsiakvdaksralfplglgh 360
Cdd:PRK08244  223 PQVpkdEPVT--LEELKTSL-----IRICGTDFgLNDPVWMSRFGNA--------TRQ---------------------- 265

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 361 AAEYVRPRVALIGDAAHRVHPLAGQGVNMGFGDISSLVRHLStAAFNGKDLGSMshLTGYETDRQRHNTALLAATDLLKR 440
Cdd:PRK08244  266 AERYRSGRIFLAGDAAHIHFPAGGQGLNVGLQDAMNLGWKLA-AAIKGWAPDWL--LDSYHAERHPVGTALLRNTEVQTK 342

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1949697010 441 L--YSTSATPLVLLRTWGLQATNAVSPLKEQIMAF 473
Cdd:PRK08244  343 LfdFTRPGLALRSMLSDLLGFPEVNRYLAGQISAL 377
FixC COG0644
Dehydrogenase (flavoprotein) [Energy production and conversion];
69-391 3.60e-05

Dehydrogenase (flavoprotein) [Energy production and conversion];


Pssm-ID: 440409 [Multi-domain]  Cd Length: 281  Bit Score: 45.34  E-value: 3.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010  69 RDKKILLLEAGPkkvleklSDTYSNRVSSISPGSATLLSSFGAWDHICNmrckAFRRMQVWdSCSEALIMFDRDNldDMG 148
Cdd:COG0644    15 AGLSVLLLEKGS-------FPGDKICGGGLLPRALEELEPLGLDEPLER----PVRGARFY-SPGGKSVELPPGR--GGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 149 YIVEndviMCALTKQL--EAVADRVRVLYRSKAVDyawpapFSMTDSSPWVhiTLGDGSTLQTKLLIGADGHNSGVRRAA 226
Cdd:COG0644    81 YVVD----RARFDRWLaeQAEEAGAEVRTGTRVTD------VLRDDGRVVV--RTGDGEEIRADYVVDADGARSLLARKL 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 227 GIQNVSWTYDQSAvvatlhlseatennVAWQRFLPSGPiallplsdtlsslVWSTSHDHAaelvsmdeEEFVDAINSAFW 306
Cdd:COG0644   149 GLKRRSDEPQDYA--------------LAIKEHWELPP-------------LEGVDPGAV--------EFFFGEGAPGGY 193

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 307 SdanhtdfvdsastmlrYVVTlLKPTRVSarqlppsiakvdaksralfpLGL---GHAAEYVRPRVALIGDAAHRVHPLA 383
Cdd:COG0644   194 G----------------WVFP-LGDGRVS--------------------VGIplgGPRPRLVGDGVLLVGDAAGFVDPLT 236


                  ....*...
gi 1949697010 384 GQGVNMGF 391
Cdd:COG0644   237 GEGIHLAM 244
mhpA PRK06183
bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase;
126-455 2.67e-03

bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase;


Pssm-ID: 235727 [Multi-domain]  Cd Length: 500  Bit Score: 40.28  E-value: 2.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 126 MQVWDSCSEALIMFDRDNLDDMGYIVENDVIMCALTKQLEAVADR---VRVLYRSKAVDyawpapFSMTDSSPWVHITLG 202
Cdd:PRK06183   81 MRFLDAKGRCLAEIARPSTGEFGWPRRNAFHQPLLEAVLRAGLARfphVRVRFGHEVTA------LTQDDDGVTVTLTDA 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 203 DG--STLQTKLLIGADGHNSGVRRAAGIQNVSWTYDQSAVV---ATLHLSEATENNVAW---QR---FLPSGP------I 265
Cdd:PRK06183  155 DGqrETVRARYVVGCDGANSFVRRTLGVPFEDLTFPERWLVvdvLIANDPLGGPHTYQYcdpARpytSVRLPHgrrrweF 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 266 ALLPlsdtlsslvwstsHDHAAElvsMDEEEFVDAINSAFWSDanhtdfvDSASTMLRYVV-TLlkptrvsarqlppsia 344
Cdd:PRK06183  235 MLLP-------------GETEEQ---LASPENVWRLLAPWGPT-------PDDAELIRHAVyTF---------------- 275

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 345 kvdaKSRalfplglgHAAEYVRPRVALIGDAAHRVHPLAGQGVNMGFGDISSLVRHLStAAFNGK---DLgsmshLTGYE 421
Cdd:PRK06183  276 ----HAR--------VADRWRSGRVLLAGDAAHLMPPFAGQGMNSGIRDAANLAWKLA-AVLRGRagdAL-----LDTYE 337

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1949697010 422 TDRQRHNTALLAATDLLKRLYSTSATPLVLLRTW 455
Cdd:PRK06183  338 QERRPHARAMIDLAVRLGRVICPTDRLAAALRDA 371
PRK07236 PRK07236
hypothetical protein; Provisional
 197-433 2.83e-03

hypothetical protein; Provisional


Pssm-ID: 235980 [Multi-domain]  Cd Length: 386  Bit Score: 39.90  E-value: 2.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 197 VHITLGDGSTLQTKLLIGADGHNSGVRRA---------AGIqnVSW--TYDQSAVVATLHlsEATENNVAWQR------- 258
Cdd:PRK07236  131 VTARFADGRRETADLLVGADGGRSTVRAQllpdvrptyAGY--VAWrgLVDEAALPPEAR--AALRDRFTFQLgpgshil 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 259 -FLPSGPIALLPLSDTLSSLVWSTSHDHAAELvsmdEEEFVDAinsafwsDANHTDF-VDSASTMLRYVVTLlkpTRVSA 336
Cdd:PRK07236  207 gYPVPGEDGSTEPGKRRYNWVWYRNAPAGEEL----DELLTDR-------DGTRRPFsVPPGALRDDVLAEL---RDDAA 272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949697010 337 RQLPPSIAKVDAKSRALF--PLGLGHAAEYVRPRVALIGDAAHRVHPLAGQGVNMGFGDISSLVRHLSTAAfngKDLGSM 414
Cdd:PRK07236  273 ELLAPVFAELVEATAQPFvqAIFDLEVPRMAFGRVALLGDAAFVARPHTAAGVAKAAADAVALAEALAAAA---GDIDAA 349

                         250
                  ....*....|....*....
gi 1949697010 415 shLTGYETDRQRHNTALLA 433
Cdd:PRK07236  350 --LAAWEAERLAVGAAIVA 366
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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