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Conserved domains on  [gi|1928047519|ref|XP_037026684|]
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irregular chiasm C-roughest protein-like [Bradysia coprophila]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 127-214 1.68e-14

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


:

Pssm-ID: 400489  Cd Length: 89  Bit Score: 69.37  E-value: 1.68e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519 127 PIISHGEFYLATAGHEFELECSSTGGKPAAELTWLDGSGNTITTGVRNikEPMPDNQRFVSKSILKIKPQKEHHNTTLTC 206
Cdd:pfam08205   1 PTIEPPASLLEGEGPEVVATCSSAGGKPAPRITWYLDGKPLEAAETSS--EQDPESGLVTVTSELKLVPSRSDHGQSLTC 78


                  ....*...
gi 1928047519 207 QSQNTADR 214
Cdd:pfam08205  79 QVSYGALR 86
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 409-492 1.44e-09

Immunoglobulin domain; This family contains immunoglobulin-like domains.


:

Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 54.88  E-value: 1.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519 409 PKIE-SPSKQYGAKGDTLRLECIAFSVPKARhISWSFNGMEINTMSDRDYSILEDpssprliKSTLIIRDSKDWHFGKYN 487
Cdd:pfam13927   2 PVITvSPSSVTVREGETVTLTCEATGSPPPT-ITWYKNGEPISSGSTRSRSLSGS-------NSTLTISNVTRSDAGTYT 73


                  ....*
gi 1928047519 488 CTVVN 492
Cdd:pfam13927  74 CVASN 78
V-set super family cl46292
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 24-121 4.37e-08

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


The actual alignment was detected with superfamily member pfam07686:

Pssm-ID: 462230  Cd Length: 109  Bit Score: 51.69  E-value: 4.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519  24 IEPEDVTAVLGTHITLPCRVTS----KQGVLQWTKDDFGLGTHRNLSAF----------ERYSMVGNDDDGDYSLKIESV 89
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSsmseASTSVYWYRQPPGKGPTFLIAYYsngseegvkkGRFSGRGDPSNGDGSLTIQNL 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1928047519  90 GLEDDAKFQCQVSPGPEG--EPGIRsnfatLTVV 121
Cdd:pfam07686  81 TLSDSGTYTCAVIPSGEGvfGKGTR-----LTVL 109
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 319-390 3.21e-07

Immunoglobulin domain; This family contains immunoglobulin-like domains.


:

Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 48.33  E-value: 3.21e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1928047519 319 PPVFKSPPKSVEADLKEEINLECDVDGNPL-EIVWVH--APAAELNFHPRVVGTTNNLKII--VSNETAGRYYCKAS 390
Cdd:pfam13927   1 KPVITVSPSSVTVREGETVTLTCEATGSPPpTITWYKngEPISSGSTRSRSLSGSNSTLTIsnVTRSDAGTYTCVAS 77
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 245-316 2.34e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member pfam07679:

Pssm-ID: 472250 [Multi-domain]  Cd Length: 90  Bit Score: 37.62  E-value: 2.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519 245 IREGDEAKFYCLADANPnVITYKWFVNEELVVGD---------YTTEMIIHRVNRSHhTATVKCEVSNDIGEAEESTILN 315
Cdd:pfam07679  12 VQEGESARFTCTVTGTP-DPEVSWFKDGQPLRSSdrfkvtyegGTYTLTISNVQPDD-SGKYTCVATNSAGEAEASAELT 89


                  .
gi 1928047519 316 V 316
Cdd:pfam07679  90 V 90
 
Name Accession Description Interval E-value
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 127-214 1.68e-14

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 69.37  E-value: 1.68e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519 127 PIISHGEFYLATAGHEFELECSSTGGKPAAELTWLDGSGNTITTGVRNikEPMPDNQRFVSKSILKIKPQKEHHNTTLTC 206
Cdd:pfam08205   1 PTIEPPASLLEGEGPEVVATCSSAGGKPAPRITWYLDGKPLEAAETSS--EQDPESGLVTVTSELKLVPSRSDHGQSLTC 78


                  ....*...
gi 1928047519 207 QSQNTADR 214
Cdd:pfam08205  79 QVSYGALR 86
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 409-492 1.44e-09

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 54.88  E-value: 1.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519 409 PKIE-SPSKQYGAKGDTLRLECIAFSVPKARhISWSFNGMEINTMSDRDYSILEDpssprliKSTLIIRDSKDWHFGKYN 487
Cdd:pfam13927   2 PVITvSPSSVTVREGETVTLTCEATGSPPPT-ITWYKNGEPISSGSTRSRSLSGS-------NSTLTISNVTRSDAGTYT 73


                  ....*
gi 1928047519 488 CTVVN 492
Cdd:pfam13927  74 CVASN 78
IgI_2_KIRREL3-like cd05759
Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar ...
 127-225 4.63e-09

Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar domains; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 (also known as Neph2). This protein has five Ig-like domains, one transmembrane domain, and a cytoplasmic tail. Included in this group is mammalian Kirrel (Neph1), Kirrel2 (Neph3), and Drosophila RST (irregular chiasm C-roughest) protein. These proteins contain multiple Ig domains, have properties of cell adhesion molecules, and are important in organ development.


Pssm-ID: 409416  Cd Length: 98  Bit Score: 53.99  E-value: 4.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519 127 PIISHGEFYLATAGHEFELECSSTGGKPAAELTWL-DGsgnTITTGVRNIKEPMPDNQRFVSKSILKIKPQKEHHNTTLT 205
Cdd:cd05759     2 PVIEGGPVISLQAGVPYNLTCRARGAKPAAEIIWFrDG---EQLEGAVYSKELLKDGKRETTVSTLLITPSDLDTGRTFT 78

                          90       100
                  ....*....|....*....|
gi 1928047519 206 CQSQNTADRNLKTAQVNIEV 225
Cdd:cd05759    79 CRARNEAIPNGKETSITLDV 98
IgI_5_KIRREL3-like cd05758
Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar ...
 409-503 1.21e-08

Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar domains; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 (also known as Neph2). This protein has five Ig-like domains, one transmembrane domain, and a cytoplasmic tail. Included in this group is mammalian Kirrel (also known as Neph1), Kirrel2 (also known as Neph3), and Drosophila RST (also known as irregular chiasm C-roughest) protein. These proteins contain multiple Ig domains, have properties of cell adhesion molecules, and are important in organ development.


Pssm-ID: 319310  Cd Length: 98  Bit Score: 52.92  E-value: 1.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519 409 PKIESPSKQYGAKGDTLRLECIAFSVPKARHISWSFNGMEINTMSDRDYSILEDPSSPRLIkSTLIIRDSKDWHFG-KYN 487
Cdd:cd05758     3 PIITAEATQPAILGEKARLECLVFSSPPPDRIVWSWDEGFLESGSSGRFSVETFPTEPGVI-SVLHISGTQRSDFQtSFN 81

                          90
                  ....*....|....*.
gi 1928047519 488 CTVVNDYGVDVLQIDL 503
Cdd:cd05758    82 CSAWNRFGEGTAIVSL 97
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 24-121 4.37e-08

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 51.69  E-value: 4.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519  24 IEPEDVTAVLGTHITLPCRVTS----KQGVLQWTKDDFGLGTHRNLSAF----------ERYSMVGNDDDGDYSLKIESV 89
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSsmseASTSVYWYRQPPGKGPTFLIAYYsngseegvkkGRFSGRGDPSNGDGSLTIQNL 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1928047519  90 GLEDDAKFQCQVSPGPEG--EPGIRsnfatLTVV 121
Cdd:pfam07686  81 TLSDSGTYTCAVIPSGEGvfGKGTR-----LTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 26-120 5.41e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 50.58  E-value: 5.41e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519   26 PEDVTAVLGTHITLPCRVTSK-QGVLQWTKDDFGLgthrnLSAFERYSMVGNDddGDYSLKIESVGLEDDAKFQCQVSPG 104
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSpPPEVTWYKQGGKL-----LAESGRFSVSRSG--STSTLTISNVTPEDSGTYTCAATNS 73

                           90
                   ....*....|....*.
gi 1928047519  105 pegePGIRSNFATLTV 120
Cdd:smart00410  74 ----SGSASSGTTLTV 85
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 414-497 1.04e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 49.81  E-value: 1.04e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519  414 PSKQYGAKGDTLRLECIAFSVPKArHISWSFNGMEINTMSDRdYSILEDPSSprlikSTLIIRDSKDWHFGKYNCTVVND 493
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPP-EVTWYKQGGKLLAESGR-FSVSRSGST-----STLTISNVTPEDSGTYTCAATNS 73


                   ....
gi 1928047519  494 YGVD 497
Cdd:smart00410  74 SGSA 77
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 319-390 3.21e-07

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 48.33  E-value: 3.21e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1928047519 319 PPVFKSPPKSVEADLKEEINLECDVDGNPL-EIVWVH--APAAELNFHPRVVGTTNNLKII--VSNETAGRYYCKAS 390
Cdd:pfam13927   1 KPVITVSPSSVTVREGETVTLTCEATGSPPpTITWYKngEPISSGSTRSRSLSGSNSTLTIsnVTRSDAGTYTCVAS 77
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 326-405 5.62e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 44.80  E-value: 5.62e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519  326 PKSVEADLKEEINLECDVDGNP-LEIVWVHAPAAELNFHPR--VVGTTNNLKIIVSN---ETAGRYYCKASViGFPEIKS 399
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPpPEVTWYKQGGKLLAESGRfsVSRSGSTSTLTISNvtpEDSGTYTCAATN-SSGSASS 79


                   ....*.
gi 1928047519  400 EANVYV 405
Cdd:smart00410  80 GTTLTV 85
IgI_1_Neogenin_like cd05722
First immunoglobulin (Ig)-like domain in neogenin, and similar domains; member of the I-set of ...
 22-120 6.13e-06

First immunoglobulin (Ig)-like domain in neogenin, and similar domains; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the first immunoglobulin (Ig)-like domain in neogenin and related proteins. Neogenin is a cell surface protein which is expressed in the developing nervous system of vertebrate embryos in the growing nerve cells. It is also expressed in other embryonic tissues and may play a general role in developmental processes such as cell migration, cell-cell recognition, and tissue growth regulation. Included in this group is the tumor suppressor protein DCC which is deleted in colorectal carcinoma. DCC and neogenin each have four Ig-like domains followed by six fibronectin type III domains, a transmembrane domain, and an intracellular domain. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409387  Cd Length: 97  Bit Score: 45.16  E-value: 6.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519  22 FVIEPEDVTAVLGTHITLPCRVTSKQG-VLQWTKDdfglGTHRNLSAFERYSMVGNDddgdySLKIESV-----GLEDDA 95
Cdd:cd05722     4 FLSEPSDIVAMRGGPVVLNCSAESDPPpKIEWKKD----GVLLNLVSDERRQQLPNG-----SLLITSVvhskhNKPDEG 74

                          90       100
                  ....*....|....*....|....*
gi 1928047519  96 KFQCQVSPGPEGEpgIRSNFATLTV 120
Cdd:cd05722    75 FYQCVAQNESLGS--IVSRTARVTV 97
IgI_4_hemolin-like cd20978
Fourth immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set ...
 319-405 9.25e-05

Fourth immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fourth immunoglobulin (Ig)-like domain of hemolin and similar proteins. Hemolin, an insect immunoglobulin superfamily (IgSF) member containing four Ig-like domains, is a lipopolysaccharide-binding immune protein induced during bacterial infection. Hemolin shares significant sequence similarity with the first four Ig-like domains of the transmembrane cell adhesion molecules (CAMs) of the L1 family. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The fourth Ig-like domain of hemolin is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409570 [Multi-domain]  Cd Length: 88  Bit Score: 41.61  E-value: 9.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519 319 PPVFKSPPKSVEADLKEEINLECDVDGNPL-EIVWVHAPAAELNFHPRVVGTTNNLKII-VSNETAGRYYCKA-SVIGfp 395
Cdd:cd20978     1 PKFIQKPEKNVVVKGGQDVTLPCQVTGVPQpKITWLHNGKPLQGPMERATVEDGTLTIInVQPEDTGYYGCVAtNEIG-- 78

                          90
                  ....*....|
gi 1928047519 396 EIKSEANVYV 405
Cdd:cd20978    79 DIYTETLLHV 88
I-set pfam07679
Immunoglobulin I-set domain;
245-316 2.34e-03

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 37.62  E-value: 2.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519 245 IREGDEAKFYCLADANPnVITYKWFVNEELVVGD---------YTTEMIIHRVNRSHhTATVKCEVSNDIGEAEESTILN 315
Cdd:pfam07679  12 VQEGESARFTCTVTGTP-DPEVSWFKDGQPLRSSdrfkvtyegGTYTLTISNVQPDD-SGKYTCVATNSAGEAEASAELT 89


                  .
gi 1928047519 316 V 316
Cdd:pfam07679  90 V 90
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 246-316 3.45e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.10  E-value: 3.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519  246 REGDEAKFYCLADANPNViTYKWFVNE----------ELVVGDYTTEMIIHRVNRSHhTATVKCEVSNDIGEAEESTILN 315
Cdd:smart00410   7 KEGESVTLSCEASGSPPP-EVTWYKQGgkllaesgrfSVSRSGSTSTLTISNVTPED-SGTYTCAATNSSGSASSGTTLT 84


                   .
gi 1928047519  316 V 316
Cdd:smart00410  85 V 85
 
Name Accession Description Interval E-value
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 127-214 1.68e-14

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 69.37  E-value: 1.68e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519 127 PIISHGEFYLATAGHEFELECSSTGGKPAAELTWLDGSGNTITTGVRNikEPMPDNQRFVSKSILKIKPQKEHHNTTLTC 206
Cdd:pfam08205   1 PTIEPPASLLEGEGPEVVATCSSAGGKPAPRITWYLDGKPLEAAETSS--EQDPESGLVTVTSELKLVPSRSDHGQSLTC 78


                  ....*...
gi 1928047519 207 QSQNTADR 214
Cdd:pfam08205  79 QVSYGALR 86
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 409-492 1.44e-09

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 54.88  E-value: 1.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519 409 PKIE-SPSKQYGAKGDTLRLECIAFSVPKARhISWSFNGMEINTMSDRDYSILEDpssprliKSTLIIRDSKDWHFGKYN 487
Cdd:pfam13927   2 PVITvSPSSVTVREGETVTLTCEATGSPPPT-ITWYKNGEPISSGSTRSRSLSGS-------NSTLTISNVTRSDAGTYT 73


                  ....*
gi 1928047519 488 CTVVN 492
Cdd:pfam13927  74 CVASN 78
IgI_2_KIRREL3-like cd05759
Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar ...
 127-225 4.63e-09

Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar domains; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 (also known as Neph2). This protein has five Ig-like domains, one transmembrane domain, and a cytoplasmic tail. Included in this group is mammalian Kirrel (Neph1), Kirrel2 (Neph3), and Drosophila RST (irregular chiasm C-roughest) protein. These proteins contain multiple Ig domains, have properties of cell adhesion molecules, and are important in organ development.


Pssm-ID: 409416  Cd Length: 98  Bit Score: 53.99  E-value: 4.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519 127 PIISHGEFYLATAGHEFELECSSTGGKPAAELTWL-DGsgnTITTGVRNIKEPMPDNQRFVSKSILKIKPQKEHHNTTLT 205
Cdd:cd05759     2 PVIEGGPVISLQAGVPYNLTCRARGAKPAAEIIWFrDG---EQLEGAVYSKELLKDGKRETTVSTLLITPSDLDTGRTFT 78

                          90       100
                  ....*....|....*....|
gi 1928047519 206 CQSQNTADRNLKTAQVNIEV 225
Cdd:cd05759    79 CRARNEAIPNGKETSITLDV 98
IgI_5_KIRREL3-like cd05758
Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar ...
 409-503 1.21e-08

Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar domains; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 (also known as Neph2). This protein has five Ig-like domains, one transmembrane domain, and a cytoplasmic tail. Included in this group is mammalian Kirrel (also known as Neph1), Kirrel2 (also known as Neph3), and Drosophila RST (also known as irregular chiasm C-roughest) protein. These proteins contain multiple Ig domains, have properties of cell adhesion molecules, and are important in organ development.


Pssm-ID: 319310  Cd Length: 98  Bit Score: 52.92  E-value: 1.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519 409 PKIESPSKQYGAKGDTLRLECIAFSVPKARHISWSFNGMEINTMSDRDYSILEDPSSPRLIkSTLIIRDSKDWHFG-KYN 487
Cdd:cd05758     3 PIITAEATQPAILGEKARLECLVFSSPPPDRIVWSWDEGFLESGSSGRFSVETFPTEPGVI-SVLHISGTQRSDFQtSFN 81

                          90
                  ....*....|....*.
gi 1928047519 488 CTVVNDYGVDVLQIDL 503
Cdd:cd05758    82 CSAWNRFGEGTAIVSL 97
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 24-121 4.37e-08

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 51.69  E-value: 4.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519  24 IEPEDVTAVLGTHITLPCRVTS----KQGVLQWTKDDFGLGTHRNLSAF----------ERYSMVGNDDDGDYSLKIESV 89
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSsmseASTSVYWYRQPPGKGPTFLIAYYsngseegvkkGRFSGRGDPSNGDGSLTIQNL 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1928047519  90 GLEDDAKFQCQVSPGPEG--EPGIRsnfatLTVV 121
Cdd:pfam07686  81 TLSDSGTYTCAVIPSGEGvfGKGTR-----LTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 26-120 5.41e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 50.58  E-value: 5.41e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519   26 PEDVTAVLGTHITLPCRVTSK-QGVLQWTKDDFGLgthrnLSAFERYSMVGNDddGDYSLKIESVGLEDDAKFQCQVSPG 104
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSpPPEVTWYKQGGKL-----LAESGRFSVSRSG--STSTLTISNVTPEDSGTYTCAATNS 73

                           90
                   ....*....|....*.
gi 1928047519  105 pegePGIRSNFATLTV 120
Cdd:smart00410  74 ----SGSASSGTTLTV 85
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 414-497 1.04e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 49.81  E-value: 1.04e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519  414 PSKQYGAKGDTLRLECIAFSVPKArHISWSFNGMEINTMSDRdYSILEDPSSprlikSTLIIRDSKDWHFGKYNCTVVND 493
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPP-EVTWYKQGGKLLAESGR-FSVSRSGST-----STLTISNVTPEDSGTYTCAATNS 73


                   ....
gi 1928047519  494 YGVD 497
Cdd:smart00410  74 SGSA 77
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 319-390 3.21e-07

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 48.33  E-value: 3.21e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1928047519 319 PPVFKSPPKSVEADLKEEINLECDVDGNPL-EIVWVH--APAAELNFHPRVVGTTNNLKII--VSNETAGRYYCKAS 390
Cdd:pfam13927   1 KPVITVSPSSVTVREGETVTLTCEATGSPPpTITWYKngEPISSGSTRSRSLSGSNSTLTIsnVTRSDAGTYTCVAS 77
I-set pfam07679
Immunoglobulin I-set domain;
21-102 6.32e-07

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 47.64  E-value: 6.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519  21 QFVIEPEDVTAVLGTHITLPCRVT-SKQGVLQWTKDDfglgthRNLSAFERYSMVgnDDDGDYSLKIESVGLEDDAKFQC 99
Cdd:pfam07679   2 KFTQKPKDVEVQEGESARFTCTVTgTPDPEVSWFKDG------QPLRSSDRFKVT--YEGGTYTLTISNVQPDDSGKYTC 73


                  ...
gi 1928047519 100 QVS 102
Cdd:pfam07679  74 VAT 76
IgI_2_Necl-1-4 cd05761
Second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 - Necl-4; member of ...
 122-225 1.09e-06

Second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 - Necl-4; member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 (also known as cell adhesion molecule 3 or CADM3), Necl-2 (also known as CADM1), Necl-3 (also known as CADM2) and Necl-4 (also known as CADM4). These nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1 through Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. The N-terminal Ig-like domain of the extracellular region belongs to the V-type subfamily of Ig domains, is essential to cell-cell adhesion, and plays a part in the interaction with the envelope glycoprotein D of various viruses. Necl-1 and Necl-2 have Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity. Necl-1 is specifically expressed in neural tissue and is important to the formation of synapses, axon bundles, and myelinated axons. Necl-2 is expressed in a wide variety of tissues, and is a putative tumour suppressor gene, which is downregulated in aggressive neuroblastoma. Necl-3 has been shown to accumulate in tissues of the central and peripheral nervous system, where it is expressed in ependymal cells and myelinated axons. It is observed at the interface between the axon shaft and the myelin sheath. Necl-4 is expressed on Schwann cells, and plays a key part in initiating peripheral nervous system (PNS) myelination. Necl-4 participates in cell-cell adhesion and is proposed to play a role in tumor suppression.


Pssm-ID: 409418  Cd Length: 102  Bit Score: 47.42  E-value: 1.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519 122 VPPEPPIIShGEFYLATAGHEFELECSSTGGKPAAELTWLdgSGNTITTGVRNIKEPmPDNQRFVSKSILKIKPQKEHHN 201
Cdd:cd05761     2 GVPEKPVIT-GFTSPVVEGDEITLTCTTSGSKPAADIRWF--KNDKELKGVKEVQES-GAGKTFTVTSTLRFRVDRDDDG 77

                          90       100
                  ....*....|....*....|....*.
gi 1928047519 202 TTLTCQSQNTA--DRNLKTAQVnIEV 225
Cdd:cd05761    78 VAVICRVDHESltSTPKQTQQV-LEV 102
IgI_2_Necl-2 cd05883
Second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (Necl-2); member of the I-set ...
 121-225 1.44e-06

Second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (Necl-2); member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (Necl-2; also known as cell adhesion molecule 1 (CADM1)). Nectin-like molecules (Necls) have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1 through Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. Necl-2 has Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity. Necl-1 is expressed in a wide variety of tissues and is a putative tumour suppressor gene which is downregulated in aggressive neuroblastoma. Ig domains are likely to participate in ligand binding and recognition.


Pssm-ID: 409466  Cd Length: 99  Bit Score: 47.22  E-value: 1.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519 121 VVPPEPPIISHGEfYLATAGHEFELECSSTGGKPAAELTWLdgSGNTITTGVRNIkEPMPDNQrFVSKSILKIKPQKEHH 200
Cdd:cd05883     1 LVPPRNLVIDIQK-DTAVEGEEIELNCTAMASKPAATIRWF--KGNKELTGKSEV-EEWYSRM-FTVTSQLMLKVTKEDD 75

                          90       100
                  ....*....|....*....|....*
gi 1928047519 201 NTTLTCQSQNTADRNLKTaQVNIEV 225
Cdd:cd05883    76 GVPVICLVDHPAVKDLQT-QRYLEV 99
I-set pfam07679
Immunoglobulin I-set domain;
409-497 3.01e-06

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 45.71  E-value: 3.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519 409 PKIESPSKQYGAK-GDTLRLECIAFSVPKArHISWSFNGMEINtmSDRDYSILEDPSSPRLIKSTLIIRDSkdwhfGKYN 487
Cdd:pfam07679   1 PKFTQKPKDVEVQeGESARFTCTVTGTPDP-EVSWFKDGQPLR--SSDRFKVTYEGGTYTLTISNVQPDDS-----GKYT 72

                          90
                  ....*....|
gi 1928047519 488 CTVVNDYGVD 497
Cdd:pfam07679  73 CVATNSAGEA 82
IgI_5_KIRREL3 cd05898
Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein; ...
 409-503 3.51e-06

Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein (also known as Neph2). This protein has five Ig-like domains, one transmembrane domain, and a cytoplasmic tail. Included in this group is mammalian Kirrel (Neph1). These proteins contain multiple Ig domains, have properties of cell adhesion molecules, and are important in organ development. Neph1 and 2 may mediate axonal guidance and synapse formation in certain areas of the CNS. In the kidney they participate in the formation of the slit diaphragm.


Pssm-ID: 409479  Cd Length: 98  Bit Score: 46.10  E-value: 3.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519 409 PKIESPSKQYGAKGDTLRLECIAFSVPKARHISWSF--NGMEINTMSdrDYSIlEDPSSPRLIKSTLIIRDSKDWHF-GK 485
Cdd:cd05898     3 PIISSEQVQYAVRGERGKVKCFIGSTPPPDRIAWAWkeNVLESGTLE--RYTV-ERTSTGSGVLSTLTINNIMEADFqTH 79

                          90
                  ....*....|....*...
gi 1928047519 486 YNCTVVNDYGVDVLQIDL 503
Cdd:cd05898    80 YNCTAWNSFGSGTAIIQL 97
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 326-405 5.62e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 44.80  E-value: 5.62e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519  326 PKSVEADLKEEINLECDVDGNP-LEIVWVHAPAAELNFHPR--VVGTTNNLKIIVSN---ETAGRYYCKASViGFPEIKS 399
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPpPEVTWYKQGGKLLAESGRfsVSRSGSTSTLTISNvtpEDSGTYTCAATN-SSGSASS 79


                   ....*.
gi 1928047519  400 EANVYV 405
Cdd:smart00410  80 GTTLTV 85
IgI_1_Neogenin_like cd05722
First immunoglobulin (Ig)-like domain in neogenin, and similar domains; member of the I-set of ...
 22-120 6.13e-06

First immunoglobulin (Ig)-like domain in neogenin, and similar domains; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the first immunoglobulin (Ig)-like domain in neogenin and related proteins. Neogenin is a cell surface protein which is expressed in the developing nervous system of vertebrate embryos in the growing nerve cells. It is also expressed in other embryonic tissues and may play a general role in developmental processes such as cell migration, cell-cell recognition, and tissue growth regulation. Included in this group is the tumor suppressor protein DCC which is deleted in colorectal carcinoma. DCC and neogenin each have four Ig-like domains followed by six fibronectin type III domains, a transmembrane domain, and an intracellular domain. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409387  Cd Length: 97  Bit Score: 45.16  E-value: 6.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519  22 FVIEPEDVTAVLGTHITLPCRVTSKQG-VLQWTKDdfglGTHRNLSAFERYSMVGNDddgdySLKIESV-----GLEDDA 95
Cdd:cd05722     4 FLSEPSDIVAMRGGPVVLNCSAESDPPpKIEWKKD----GVLLNLVSDERRQQLPNG-----SLLITSVvhskhNKPDEG 74

                          90       100
                  ....*....|....*....|....*
gi 1928047519  96 KFQCQVSPGPEGEpgIRSNFATLTV 120
Cdd:cd05722    75 FYQCVAQNESLGS--IVSRTARVTV 97
Ig_LP_like cd05877
Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The ...
 25-111 1.16e-05

Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The members here are composed of the immunoglobulin (Ig)-like domain similar to that found in human cartilage link protein (LP; also called hyaluronan and proteoglycan link protein). In cartilage, chondroitin-keratan sulfate proteoglycan (CSPG), aggrecan, forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409461  Cd Length: 117  Bit Score: 45.01  E-value: 1.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519  25 EPEDVTAVLGTHITLPCRVTSKQGV-------LQWTK--DDFG--------LGTH-RNLSAFERYSMVGNDDDGDYSLKI 86
Cdd:cd05877     3 VQAKVFSHRGGNVTLPCRYHYEPELsaprkirVKWTKleVDYAkeedvlvaIGTRhKSYGSYQGRVFLRRADDLDASLVI 82

                          90       100
                  ....*....|....*....|....*
gi 1928047519  87 ESVGLEDDAKFQCQVSPGPEGEPGI 111
Cdd:cd05877    83 TDLRLEDYGRYRCEVIDGLEDESVV 107
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 422-492 3.21e-05

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 42.95  E-value: 3.21e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1928047519 422 GDTLRLECIAFSVPKARHISWSFNGMEINTmsdrdySILEDPSSPRLIKSTLIIRDSKDWHFGKYNCTVVN 492
Cdd:pfam00047  11 GDSATLTCSASTGSPGPDVTWSKEGGTLIE------SLKVKHDNGRTTQSSLLISNVTKEDAGTYTCVVNN 75
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 21-102 3.86e-05

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 42.55  E-value: 3.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519  21 QFVIEPEDVTAVLGTHITLPCRVTSK-QGVLQWTKDDfGLGTHRNLSAFERYSMVGndddgdySLKIESVGLEDDAKFQC 99
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEATGSpPPTITWYKNG-EPISSGSTRSRSLSGSNS-------TLTISNVTRSDAGTYTC 74


                  ...
gi 1928047519 100 QVS 102
Cdd:pfam13927  75 VAS 77
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 425-495 4.17e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 41.93  E-value: 4.17e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1928047519 425 LRLECIAFSVPKArHISWSFNGMEINTMSDRDYSILEDpssprliKSTLIIRDSKDWHFGKYNCTVVNDYG 495
Cdd:cd00096     1 VTLTCSASGNPPP-TITWYKNGKPLPPSSRDSRRSELG-------NGTLTISNVTLEDSGTYTCVASNSAG 63
IgC2_CD33_d2_like cd20987
Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member ...
 121-207 8.23e-05

Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member of the C2-set of IgSF domains; The members here are composed of the second immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 33 (also known as sialic-acid binding immunoglobulin type-lectin 3 (Siglec-3)) and related Siglecs. CD33, a Siglec family member, is a well-known immunotherapeutic target in acute myeloid leukemia (AML). It is an inhibitory sialoadhesin expressed in human leukocytes of the myeloid lineage and some lymphoid subsets, including natural killer (NK) cells. Siglecs are primarily expressed on immune cells and recognize sialic acid-containing glycan ligands. Siglecs are organized as an extracellular module composed of Ig-like domains (an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains), followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG (Siglec-4, myelin-associated glycoprotein), the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11. CD33 (Siglec-3) is the smallest Siglec member. It preferentially binds to alpha2-6- and alpha2-3-sialylated glycans and strongly binds to sialylated ligands on leukemic cell lines. Ig Superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group includes CD33-related Siglecs which belong to the C2-set of IgSF domains. Unlike the C1-set, the C2-set structures do not have a D strand.


Pssm-ID: 409579  Cd Length: 94  Bit Score: 41.79  E-value: 8.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519 121 VVPPEPPIishgefylatAGHEFELECSSTGGKPA--AELTWL--DGSGNTITTGVRNikepmpDNQRFVSKSILKIKPQ 196
Cdd:cd20987     3 IHVPEELE----------AGQEVTLTCSVPDNCPAlsPEFSWLgaALTPLPPVLGRLE------EEGTTTHSSVLTFTPR 66

                          90
                  ....*....|.
gi 1928047519 197 KEHHNTTLTCQ 207
Cdd:cd20987    67 PEDHGTNLTCQ 77
IgI_4_hemolin-like cd20978
Fourth immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set ...
 319-405 9.25e-05

Fourth immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fourth immunoglobulin (Ig)-like domain of hemolin and similar proteins. Hemolin, an insect immunoglobulin superfamily (IgSF) member containing four Ig-like domains, is a lipopolysaccharide-binding immune protein induced during bacterial infection. Hemolin shares significant sequence similarity with the first four Ig-like domains of the transmembrane cell adhesion molecules (CAMs) of the L1 family. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The fourth Ig-like domain of hemolin is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409570 [Multi-domain]  Cd Length: 88  Bit Score: 41.61  E-value: 9.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519 319 PPVFKSPPKSVEADLKEEINLECDVDGNPL-EIVWVHAPAAELNFHPRVVGTTNNLKII-VSNETAGRYYCKA-SVIGfp 395
Cdd:cd20978     1 PKFIQKPEKNVVVKGGQDVTLPCQVTGVPQpKITWLHNGKPLQGPMERATVEDGTLTIInVQPEDTGYYGCVAtNEIG-- 78

                          90
                  ....*....|
gi 1928047519 396 EIKSEANVYV 405
Cdd:cd20978    79 DIYTETLLHV 88
IgC1_2_Nectin-2_Necl-5_like cd07703
Second immunoglobulin (Ig) domain of Nectin-2 and Nectin-like protein 5, and similar domains; ...
 147-206 9.44e-05

Second immunoglobulin (Ig) domain of Nectin-2 and Nectin-like protein 5, and similar domains; member of the C1-set of the Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or Cluster of Differentiation 112 (CD112)), nectin-like protein 5 (CD155), and similar proteins. Nectins and Nectin-like molecules are a family of Ca(2+)-independent immunoglobulin-like transmembrane glycoproteins belonging to the class of adhesion receptors, consisting of nine members (nectins 1 through 4 and nectin-like proteins 1 through 5). Nectins are synaptic cell adhesion molecules (CAMs) which facilitate adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. Nectin-2 and nectin-3 localize at Sertoli-spermatid junctions where they form heterophilic trans-interactions between the cells that are essential for the formation and maintenance of the junctions and for spermatid development. CD155 is the fifth member in the nectin-like molecule family, and functions as the receptor of poliovirus; therefore, CD155 is also referred to as Necl-5, or PVR. In contrast to all other family members, CD155 lacks self-adhesion capacity, yet it shares with nectins the feature to interact with other nectins. For instance, CD155 heterophilically trans-interacts with nectin-3, thereby contributing significantly to the establishment of adherens junctions between epithelial cells. This group belongs to the Constant 1 (C1)-set of IgSF domains, which has one beta-sheet that is formed by strands A-B-E-D and the other strands by G-F-C-C'.


Pssm-ID: 409500  Cd Length: 97  Bit Score: 42.00  E-value: 9.44e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1928047519 147 CSSTGGKPAAELTW---LDGSGNTittgvrnIKEPMPDNQRFVSKSILKIKPQKEHHNTTLTC 206
Cdd:cd07703    22 CVSANGRPPARISWsstLNGNANT-------TQVPGPDSGTVTVTSEYSLVPTPEANGKEVTC 77
IgI_4_hemolin-like cd20978
Fourth immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set ...
 411-495 2.39e-04

Fourth immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fourth immunoglobulin (Ig)-like domain of hemolin and similar proteins. Hemolin, an insect immunoglobulin superfamily (IgSF) member containing four Ig-like domains, is a lipopolysaccharide-binding immune protein induced during bacterial infection. Hemolin shares significant sequence similarity with the first four Ig-like domains of the transmembrane cell adhesion molecules (CAMs) of the L1 family. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The fourth Ig-like domain of hemolin is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409570 [Multi-domain]  Cd Length: 88  Bit Score: 40.45  E-value: 2.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519 411 IESPSKQYGAK-GDTLRLECIAFSVPKArHISWSFNGMEINTMSDRdySILEDpssprlikSTLIIRDSKDWHFGKYNCT 489
Cdd:cd20978     4 IQKPEKNVVVKgGQDVTLPCQVTGVPQP-KITWLHNGKPLQGPMER--ATVED--------GTLTIINVQPEDTGYYGCV 72


                  ....*.
gi 1928047519 490 VVNDYG 495
Cdd:cd20978    73 ATNEIG 78
Ig5_Contactin cd04969
Fifth immunoglobulin (Ig) domain of contactin; The members here are composed of the fifth ...
 419-495 3.04e-04

Fifth immunoglobulin (Ig) domain of contactin; The members here are composed of the fifth immunoglobulin (Ig) domain of contactins. Contactins are neural cell adhesion molecules and are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. The first four Ig domains form the intermolecular binding fragment, which arranges as a compact U-shaped module via contacts between Ig domains 1 and 4, and between Ig domains 2 and 3. Contactin-2 (TAG-1, axonin-1) may play a part in the neuronal processes of neurite outgrowth, axon guidance and fasciculation, and neuronal migration. This group also includes contactin-1 and contactin-5. The different contactins show different expression patterns in the central nervous system. During development and in adulthood, contactin-2 is transiently expressed in subsets of central and peripheral neurons. Contactin-5 is expressed specifically in the rat postnatal nervous system, peaking at about 3 weeks postnatal, and a lack of contactin-5 (NB-2) results in an impairment of neuronal activity in the rat auditory system. Contactin-5 is highly expressed in the adult human brain in the occipital lobe and in the amygdala. Contactin-1 is differentially expressed in tumor tissues and may, through a RhoA mechanism, facilitate invasion and metastasis of human lung adenocarcinoma.


Pssm-ID: 409358 [Multi-domain]  Cd Length: 89  Bit Score: 40.14  E-value: 3.04e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1928047519 419 GAKGDTLRLECIAFSVPKARhISWSFNGmEINTMSDRdYSILEDpssprlikSTLIIRDSKDWHFGKYNCTVVNDYG 495
Cdd:cd04969    14 AAKGGDVIIECKPKASPKPT-ISWSKGT-ELLTNSSR-ICILPD--------GSLKIKNVTKSDEGKYTCFAVNFFG 79
IgV_1_Nectin-2_NecL-5_like_CD112_CD155 cd20989
First immunoglobulin variable (IgV) domain of nectin-2, nectin-like protein 5, and similar ...
 23-107 3.22e-04

First immunoglobulin variable (IgV) domain of nectin-2, nectin-like protein 5, and similar domains; The members here are composed of the second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or Cluster of Differentiation 112 (CD112)), nectin-like protein 5 (CD155), and similar proteins. Nectins and Nectin-like molecules are a family of Ca(2+)-independent immunoglobulin-like transmembrane glycoproteins belonging to the class of adhesion receptors, consisting of nine members (nectins 1 through 4 and nectin-like proteins 1 through 5). Nectins are synaptic cell adhesion molecules (CAMs) which facilitate adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. Nectin-2 and nectin-3 localize at Sertoli-spermatid junctions where they form heterophilic trans-interactions between the cells that are essential for the formation and maintenance of the junctions and for spermatid development. CD155 is the fifth member in the nectin-like molecule family, and functions as the receptor of poliovirus; therefore, CD155 is also referred to as Necl-5, or PVR. In contrast to all other family members, CD155 lacks self-adhesion capacity, yet it shares with nectins the feature to interact with other nectins. For instance, CD155 heterophilically trans-interacts with nectin-3, thereby contributing significantly to the establishment of adherens junctions between epithelial cells. This group belongs to the Constant 1 (C1)-set of IgSF domains, which has one beta-sheet that is formed by strands A-B-E-D and the other strands by G-F-C-C'.


Pssm-ID: 409581  Cd Length: 112  Bit Score: 40.64  E-value: 3.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519  23 VIEPEDVTAVLGTHITLPCRVTSKQGV-----LQWTKDDfglgTHRNLSAF-----------ERYSMVG---NDDDGDYS 83
Cdd:cd20989     3 VQVPPEVRGFLGGSVTLPCHLLPPNMVthvsqVTWQRHD----EHGSVAVFhpkqgpsfpesERLSFVAarlGAELRNAS 78

                          90       100
                  ....*....|....*....|....
gi 1928047519  84 LKIESVGLEDDAKFQCQVSPGPEG 107
Cdd:cd20989    79 LAMFGLRVEDEGNYTCEFATFPQG 102
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
 21-120 5.11e-04

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 40.12  E-value: 5.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519  21 QFVIEPEDVTAVLGTHITLPCRVTSKQGV----LQWTKDDfgLGTHRNLSAF-------------ERYSMV-GNDDDGDY 82
Cdd:cd05718     1 QRVQVPTEVTGFLGGSVTLPCSLTSPGTTkitqVTWMKIG--AGSSQNVAVFhpqygpsvpnpyaERVEFLaARLGLRNA 78

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1928047519  83 SLKIESVGLEDDAKFQCQVSPGPEGEpgiRSNFATLTV 120
Cdd:cd05718    79 TLRIRNLRVEDEGNYICEFATFPQGN---RQGTTWLRV 113
IgI_2_Necl-4 cd05885
Second immunoglobulin (Ig)-like domain of nectin-like molecule-4 (Necl-4); member of the ...
 121-212 7.92e-04

Second immunoglobulin (Ig)-like domain of nectin-like molecule-4 (Necl-4); member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin (Ig)-like domain of nectin-like molecule-4 (Necl-4; also known as cell adhesion molecule 4 (CADM4)). Nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1-Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. Ig domains are likely to participate in ligand binding and recognition. Necl-4 is expressed on Schwann cells, and plays a key part in initiating peripheral nervous system (PNS) myelination. In injured peripheral nerve cells, the mRNA signal for both Necl-4 and Necl-5 was observed to be elevated. Necl-4 participates in cell-cell adhesion and is proposed to play a role in tumor suppression.


Pssm-ID: 409468  Cd Length: 100  Bit Score: 39.17  E-value: 7.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519 121 VVPPEPPIISHGEfyLATAGHEFELECSSTGGKPAAELTWldgsgntittgVRNIKE-----PMPDNQRFVS-KSILKIK 194
Cdd:cd05885     1 LVAPENPVVEVRE--QAVEGGEVELSCLVPRSRPAATLRW-----------YRDRKElkgvsSGQENGKVWSvASTVRFR 67

                          90
                  ....*....|....*...
gi 1928047519 195 PQKEHHNTTLTCQSQNTA 212
Cdd:cd05885    68 VDRKDDGGIVICEAQNQA 85
I-set pfam07679
Immunoglobulin I-set domain;
320-405 9.24e-04

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 38.78  E-value: 9.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519 320 PVFKSPPKSVEADLKEEINLECDVDGNPL-EIVWVH--APAAELNFHpRVVGTTNNLKIIVSN---ETAGRYYCKASViG 393
Cdd:pfam07679   1 PKFTQKPKDVEVQEGESARFTCTVTGTPDpEVSWFKdgQPLRSSDRF-KVTYEGGTYTLTISNvqpDDSGKYTCVATN-S 78

                          90
                  ....*....|..
gi 1928047519 394 FPEIKSEANVYV 405
Cdd:pfam07679  79 AGEAEASAELTV 90
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 37-108 2.23e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 37.31  E-value: 2.23e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1928047519  37 ITLPCRVTSKQG-VLQWTKDDFGLGTHRNLSAFErysmvgndDDGDYSLKIESVGLEDDAKFQCQVSPGPEGE 108
Cdd:cd00096     1 VTLTCSASGNPPpTITWYKNGKPLPPSSRDSRRS--------ELGNGTLTISNVTLEDSGTYTCVASNSAGGS 65
I-set pfam07679
Immunoglobulin I-set domain;
245-316 2.34e-03

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 37.62  E-value: 2.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519 245 IREGDEAKFYCLADANPnVITYKWFVNEELVVGD---------YTTEMIIHRVNRSHhTATVKCEVSNDIGEAEESTILN 315
Cdd:pfam07679  12 VQEGESARFTCTVTGTP-DPEVSWFKDGQPLRSSdrfkvtyegGTYTLTISNVQPDD-SGKYTCVATNSAGEAEASAELT 89


                  .
gi 1928047519 316 V 316
Cdd:pfam07679  90 V 90
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 26-105 2.75e-03

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 38.08  E-value: 2.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519  26 PEDVTAVLGTHITLPCRVTS--KQGVLQW--TKDDFGL---------GTHRNLSAFERYSMVGNDDDgDYSLKIESVGLE 92
Cdd:cd00099     5 PRSLSVQEGESVTLSCEVSSsfSSTYIYWyrQKPGQGPefliylsssKGKTKGGVPGRFSGSRDGTS-SFSLTISNLQPE 83

                          90
                  ....*....|...
gi 1928047519  93 DDAKFQCQVSPGP 105
Cdd:cd00099    84 DSGTYYCAVSESG 96
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 246-316 3.45e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.10  E-value: 3.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519  246 REGDEAKFYCLADANPNViTYKWFVNE----------ELVVGDYTTEMIIHRVNRSHhTATVKCEVSNDIGEAEESTILN 315
Cdd:smart00410   7 KEGESVTLSCEASGSPPP-EVTWYKQGgkllaesgrfSVSRSGSTSTLTISNVTPED-SGTYTCAATNSSGSASSGTTLT 84


                   .
gi 1928047519  316 V 316
Cdd:smart00410  85 V 85
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 232-303 5.68e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 36.39  E-value: 5.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519 232 QLTIENSNEPnngIREGDEAKFYCLADANPNViTYKWFVNEELV---------VGDYTTEMIIHRVNRShHTATVKCEVS 302
Cdd:pfam13927   3 VITVSPSSVT---VREGETVTLTCEATGSPPP-TITWYKNGEPIssgstrsrsLSGSNSTLTISNVTRS-DAGTYTCVAS 77


                  .
gi 1928047519 303 N 303
Cdd:pfam13927  78 N 78
IgV_CAR_like cd20960
Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and ...
 70-119 6.56e-03

Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins; The members here are composed of the Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins. CAR, which is encoded by human CXADR gene, is a cell adhesion molecule of the Immunoglobulin (Ig) superfamily. The CAR acts as a type I membrane receptor for group B1-B6 coxsackie viruses and subgroup C adenoviruses. For instance, adenovirus interacts with the coxsackievirus and adenovirus receptor to enter epithelial airway cells. The CAR is also shown to be involved in physiological processes such as neuronal and heart development, epithelial tight junction integrity, and tumor suppression. The CAR is a component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. The CAR is also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. The CAR is composed of one V-set and one C2-set Ig module, a single transmembrane helix, and an intracellular domain. This group belongs to the V-set of IgSF domains, having A, B, E and D strands in one beta-sheet and A', G, F, C, C' and C" in the other


Pssm-ID: 409552  Cd Length: 114  Bit Score: 37.05  E-value: 6.56e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1928047519  70 RYSMVGNDDDGDYSLKIESVGLEDDAKFQCQVSPGpegePGIRSNFATLT 119
Cdd:cd20960    69 RVAFTSNDLSGDASLNISNLKLSDTGTYQCKVKKA----PGYAWSKITLI 114
IgV_P0-like cd05715
Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here ...
 23-110 8.15e-03

Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here are composed of the immunoglobulin (Ig) domain of protein zero (P0), a myelin membrane adhesion molecule. P0 accounts for over 50% of the total protein in peripheral nervous system (PNS) myelin. P0 is a single-pass transmembrane glycoprotein with a highly basic intracellular domain and an extracellular Ig domain. The extracellular domain of P0 (P0-ED) is similar to the Ig variable domain, carrying one acceptor sequence for N-linked glycosylation. P0 plays a role in membrane adhesion in the spiral wraps of the myelin sheath. The intracellular domain is thought to mediate membrane apposition of the cytoplasmic faces and may, through electrostatic interactions, interact directly with lipid headgroups. It is thought that homophilic interactions of the P0 extracellular domain mediate membrane juxtaposition in the extracellular space of PNS myelin. This group also contains the Ig domain of sodium channel subunit beta-2 (SCN2B), and of epithelial V-like antigen 1 (EVA). EVA, also known as myelin protein zero-like 2, is an adhesion molecule, which may play a role in structural organization of the thymus and early lymphocyte development. SCN2B subunits play a role in determining sodium channel density and function in neurons,and in control of electrical excitability in the brain.


Pssm-ID: 409380  Cd Length: 117  Bit Score: 37.02  E-value: 8.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928047519  23 VIEPEDVTAVLGTHITLPCRVTS-----KQGVLQWTKDDFGLGT-------HR------NLSAF-ERYSMVGNDDDGDYS 83
Cdd:cd05715     3 VYTPRELNVLNGSDVRLTCTFTScytvgDAFSVTWTYQPEGGNTtesmfhySKgkpyilKVGRFkDRVSWAGNPSKKDAS 82

                          90       100
                  ....*....|....*....|....*....
gi 1928047519  84 LKIESVGLEDDAKFQCQVSPGPE--GEPG 110
Cdd:cd05715    83 IVISNLQFSDNGTYTCDVKNPPDivGGHG 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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