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Conserved domains on  [gi|1907124315|ref|XP_036016487|]
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uncharacterized protein LOC240041 isoform X1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12017129)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 27-67 5.52e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.37  E-value: 5.52e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907124315  27 LLTFKEVAVDFSQEEWECLDCAQRALYMDVMLENYNNLLFV 67
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
391-780 3.19e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 3.19e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124315 391 NTYKCSECDKCFTQRCLLRTHQRIHSGEKPYKCSECGKAFAGGSY--LRSHQRIHSEKKPYKCSDCDKSFHRK-DHLRIH 467
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNSKSLPLSNSKaSSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124315 468 QRIHTGEKPYKCSECDKCFTQKGSVRIHQRIHTGEKPYKCSKCDKSFTKKD-CLKIHQIIHTGEEPykcsecdTSFNRKD 546
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqSNSLHPPLPANSLS-------KDPSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124315 547 HLRTHQRFHTGERIYKCSECDESFTQKINLRIHQKIHTGDNSYKCS----GCDKSFNRRNHLRTHERIHAGEKPYNCREF 622
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTtnsqLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124315 623 --ENSFIQTGSLRIHQRLHSRKKL-YKCRECDKSFTSSSYVRIHQR--IHSGE--KPYKCSE--CGKCFTSGSYLRMHQR 693
Cdd:COG5048   265 lpTASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124315 694 IHTGDKPYKC------SDCDKCFTQKCSLRIHQRSHTGEKPYKCG---NCDRSFTSGSYLRIHQRIHRGEKPH--KCSEC 762
Cdd:COG5048   345 LHTSISPAKEkllnssSKFSPLLNNEPPQSLQQYKDLKNDKKSETlsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPC 424

                         410
                  ....*....|....*...
gi 1907124315 763 DKSFTQKGYLRIHQRIHK 780
Cdd:COG5048   425 SKSFNRHYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
352-376 7.96e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.96e-03
                          10        20
                  ....*....|....*....|....*
gi 1907124315 352 LKIHQRIHTGERPYKCGDCDKSFTQ 376
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 27-67 5.52e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.37  E-value: 5.52e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907124315  27 LLTFKEVAVDFSQEEWECLDCAQRALYMDVMLENYNNLLFV 67
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
28-86 8.10e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 83.41  E-value: 8.10e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907124315   28 LTFKEVAVDFSQEEWECLDCAQRALYMDVMLENYNNLLFVEnnHHVCvKHDEV--LGQGSK 86
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG--FQVP-KPDLIsqLEQGEE 58
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 28-66 2.31e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.05  E-value: 2.31e-17
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907124315  28 LTFKEVAVDFSQEEWECLDCAQRALYMDVMLENYNNLLF 66
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
391-780 3.19e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 3.19e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124315 391 NTYKCSECDKCFTQRCLLRTHQRIHSGEKPYKCSECGKAFAGGSY--LRSHQRIHSEKKPYKCSDCDKSFHRK-DHLRIH 467
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNSKSLPLSNSKaSSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124315 468 QRIHTGEKPYKCSECDKCFTQKGSVRIHQRIHTGEKPYKCSKCDKSFTKKD-CLKIHQIIHTGEEPykcsecdTSFNRKD 546
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqSNSLHPPLPANSLS-------KDPSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124315 547 HLRTHQRFHTGERIYKCSECDESFTQKINLRIHQKIHTGDNSYKCS----GCDKSFNRRNHLRTHERIHAGEKPYNCREF 622
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTtnsqLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124315 623 --ENSFIQTGSLRIHQRLHSRKKL-YKCRECDKSFTSSSYVRIHQR--IHSGE--KPYKCSE--CGKCFTSGSYLRMHQR 693
Cdd:COG5048   265 lpTASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124315 694 IHTGDKPYKC------SDCDKCFTQKCSLRIHQRSHTGEKPYKCG---NCDRSFTSGSYLRIHQRIHRGEKPH--KCSEC 762
Cdd:COG5048   345 LHTSISPAKEkllnssSKFSPLLNNEPPQSLQQYKDLKNDKKSETlsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPC 424

                         410
                  ....*....|....*...
gi 1907124315 763 DKSFTQKGYLRIHQRIHK 780
Cdd:COG5048   425 SKSFNRHYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
463-488 1.23e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.23e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907124315 463 HLRIHQRIHTGEKPYKCSECDKCFTQ 488
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
352-376 7.96e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.96e-03
                          10        20
                  ....*....|....*....|....*
gi 1907124315 352 LKIHQRIHTGERPYKCGDCDKSFTQ 376
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 27-67 5.52e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.37  E-value: 5.52e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907124315  27 LLTFKEVAVDFSQEEWECLDCAQRALYMDVMLENYNNLLFV 67
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
28-86 8.10e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 83.41  E-value: 8.10e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907124315   28 LTFKEVAVDFSQEEWECLDCAQRALYMDVMLENYNNLLFVEnnHHVCvKHDEV--LGQGSK 86
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG--FQVP-KPDLIsqLEQGEE 58
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 28-66 2.31e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.05  E-value: 2.31e-17
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907124315  28 LTFKEVAVDFSQEEWECLDCAQRALYMDVMLENYNNLLF 66
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
391-780 3.19e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 3.19e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124315 391 NTYKCSECDKCFTQRCLLRTHQRIHSGEKPYKCSECGKAFAGGSY--LRSHQRIHSEKKPYKCSDCDKSFHRK-DHLRIH 467
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNSKSLPLSNSKaSSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124315 468 QRIHTGEKPYKCSECDKCFTQKGSVRIHQRIHTGEKPYKCSKCDKSFTKKD-CLKIHQIIHTGEEPykcsecdTSFNRKD 546
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqSNSLHPPLPANSLS-------KDPSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124315 547 HLRTHQRFHTGERIYKCSECDESFTQKINLRIHQKIHTGDNSYKCS----GCDKSFNRRNHLRTHERIHAGEKPYNCREF 622
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTtnsqLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124315 623 --ENSFIQTGSLRIHQRLHSRKKL-YKCRECDKSFTSSSYVRIHQR--IHSGE--KPYKCSE--CGKCFTSGSYLRMHQR 693
Cdd:COG5048   265 lpTASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124315 694 IHTGDKPYKC------SDCDKCFTQKCSLRIHQRSHTGEKPYKCG---NCDRSFTSGSYLRIHQRIHRGEKPH--KCSEC 762
Cdd:COG5048   345 LHTSISPAKEkllnssSKFSPLLNNEPPQSLQQYKDLKNDKKSETlsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPC 424

                         410
                  ....*....|....*...
gi 1907124315 763 DKSFTQKGYLRIHQRIHK 780
Cdd:COG5048   425 SKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
176-607 8.71e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 8.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124315 176 DEAFLSKYKLMLKGNNSGMKSHKCRKSGKFFTMTSSLSGHPRDHAREKPYQCT----KCSKSFLHLSHlQLHYKIHFGGY 251
Cdd:COG5048    13 NSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysgcDKSFSRPLELS-RHLRTHHNNPS 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124315 252 PYKCTECGKCFYHASGFErhcRIHATKNTYKCSFCSKSFICCSGLRKHQKIHEENRLFECNQDTRsfCTFSYRECHYRAD 331
Cdd:COG5048    92 DLNSKSLPLSNSKASSSS---LSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPG--NNSSSVNTPQSNS 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124315 332 IRKKCyRCKECGKSLSTSSGLKIHQRIHTGERPYKCGDCDKSFTQKSNLRMHQKIHTGENTYKCSECDKCFTQRCLLRTH 411
Cdd:COG5048   167 LHPPL-PANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSP 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124315 412 QRIHSGEKPYKCSECGKAFAG--GSYLRSHQRIHSEK-----KPYKCSDCDKSFHRKDHLRIHQR--IHTGE--KPYKCS 480
Cdd:COG5048   246 SSLSSSDSSSSASESPRSSLPtaSSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCP 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124315 481 E--CDKCFTQKGSVRIHQRIHTGEKPYKC------SKCDKSFTKKDCLKIHQIIHTGEEPYKC---SECDTSFNRKDHLR 549
Cdd:COG5048   326 YslCGKLFSRNDALKRHILLHTSISPAKEkllnssSKFSPLLNNEPPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLS 405

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124315 550 THQRFHTGERI--YKCSECDESFTQKINLRIHQKIHTGDNSYKCSGCdKSFNRRNHLRTH 607
Cdd:COG5048   406 LHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSIL-KSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
334-748 8.71e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 8.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124315 334 KKCYRCKECGKSLSTSSGLKIHQRIHTGERPYKCGD--CDKSFTQKSNLRMHQKIHTGENTYKCSecDKCFTQRCLLRTH 411
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNS--KSLPLSNSKASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124315 412 QRIHSGE---KPYKCSECGKAFAGGSYLRSHQRIHSEKKPYKCSDCDKSFHRKD-HLRIHQRIHTGEKPYKCSECDkcft 487
Cdd:COG5048   109 SLSSSSSnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqSNSLHPPLPANSLSKDPSSNL---- 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124315 488 qkgSVRIHQRIHTGEKPYKCSKCDKSFTKKDCLKIHQIIHTGEEPYKCSECdtSFNRKDHLRTHQRFHTGERIYK--CSE 565
Cdd:COG5048   185 ---SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSSSDSSssASE 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124315 566 CDESFTQKINLRIHQKIHTG-------DNSYKCSGCDKSFNRRNHLRTHER--IHAGE--KPYNCREFENS--FIQTGSL 632
Cdd:COG5048   260 SPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYSLCGklFSRNDAL 339

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124315 633 RIHQRLHSRKKLYKC--RECDKSFTSSSYVRIHQRI--HSGEKPYKCSEC--GKC---FTSGSYLRMHQRIHTGDKP--Y 701
Cdd:COG5048   340 KRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETlsNSCirnFKRDSNLSLHIITHLSFRPynC 419

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 1907124315 702 KCSDCDKCFTQKCSLRIHQRSHTGEKPYKCGNCDRSFTSGSYLRIHQ 748
Cdd:COG5048   420 KNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
463-488 1.23e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.23e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907124315 463 HLRIHQRIHTGEKPYKCSECDKCFTQ 488
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 361-444 1.28e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907124315 361 GERPYKCG--DCDKSFTQKSNLRMHQKI-HTGENTYKCSECDKcftqrcllrtHQRIHSGEKPYKCSECGKAFAGGSYLR 437
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ....*..
gi 1907124315 438 SHqRIHS 444
Cdd:COG5189   416 YH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
687-712 2.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.07e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907124315 687 YLRMHQRIHTGDKPYKCSDCDKCFTQ 712
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
743-768 2.89e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.89e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907124315 743 YLRIHQRIHRGEKPHKCSECDKSFTQ 768
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
408-431 3.84e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.84e-03
                          10        20
                  ....*....|....*....|....
gi 1907124315 408 LRTHQRIHSGEKPYKCSECGKAFA 431
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 447-523 4.85e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 4.85e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907124315 447 KPYKCS--DCDKSFHRKDHLRIHqRIHtgekpykcSECDKCFTQKGSVRIHQRIHTGEKPYKCSKCDKSFTKKDCLKIH 523
Cdd:COG5189   348 KPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
352-376 7.96e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.96e-03
                          10        20
                  ....*....|....*....|....*
gi 1907124315 352 LKIHQRIHTGERPYKCGDCDKSFTQ 376
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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