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Conserved domains on  [gi|1907079978|ref|XP_036012217|]
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envoplakin isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SH3_10 pfam17902
SH3 domain; This entry represents an SH3 domain.
 404-468 7.87e-25

SH3 domain; This entry represents an SH3 domain.


:

Pssm-ID: 407754  Cd Length: 65  Bit Score: 99.26  E-value: 7.87e-25
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907079978  404 PLPQRRNPSKQPLHVDSICDWDSGEVQLLRGERYTLKDNADPYTWLVQGPGGETKSAPAACLCIP 468
Cdd:pfam17902    1 PLKQRRSPVTRPIPVKALCDYKQGEVTVEKGEECTLLDNSDREKWKVQTSSGVEKLVPSVCFLIP 65
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 908-1703 2.61e-24

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 112.07  E-value: 2.61e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  908 ESIQAQEKnLAKAYTEVaaaeQQQLRQLEFAKKMLRKKELDEDIQAIHSARQGSGSPAHARTAESEVLKTQLEEERKRVA 987
Cdd:TIGR02168  203 KSLERQAE-KAERYKEL----KAELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVS 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  988 EVQRDLEEQRQRLLQLRTQQpvARLEEKEVVEFYRDPQLESNLSQAASRVEEEGKRRARLQAELEAVAQKVVHLEGKRKT 1067
Cdd:TIGR02168  278 ELEEEIEELQKELYALANEI--SRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELES 355

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1068 MQPHLLTKEVTQIERDPG---LDSQVTQLHSEMQRLRGENGVLTARLEELKDELLALEQKEMNVKEKVVVKEVVKVEKDL 1144
Cdd:TIGR02168  356 LEAELEELEAELEELESRleeLEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAEL 435

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1145 EMVKAA-QTLRLQIEEDAARRKGAKETVAKIQARIKDLEQAISSVEpkvivkevkkveqdpgllKEASRLRSLLEeeknn 1223
Cdd:TIGR02168  436 KELQAElEELEEELEELQEELERLEEALEELREELEEAEQALDAAE------------------RELAQLQARLD----- 492

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1224 nvALARELQELQEKYR----VVEKQKPKVQLQERVSEIFQVLPETEQEIRR-LRAQLQE-TGSKKSGVEQEVEKLLP--- 1294
Cdd:TIGR02168  493 --SLERLQENLEGFSEgvkaLLKNQSGLSGILGVLSELISVDEGYEAAIEAaLGGRLQAvVVENLNAAKKAIAFLKQnel 570

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1295 ------ELEVLRAQKPVVEYKEVTQEV-------VRHEKNPEVLRE-----------IDRLKAQLNELVNTNGRsqEQLI 1350
Cdd:TIGR02168  571 grvtflPLDSIKGTEIQGNDREILKNIegflgvaKDLVKFDPKLRKalsyllggvlvVDDLDNALELAKKLRPG--YRIV 648

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1351 RLQGERDEWK----RERSKVETKMVSKEVVRHEkdpvLEKEAERLRQEVREAVQRRRATEDAVYELQNKLLLLERRRPEE 1426
Cdd:TIGR02168  649 TLDGDLVRPGgvitGGSAKTNSSILERRREIEE----LEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEEL 724

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1427 QIVVQEvvvtqkdpkLREEHSRLSRSLDEEVGRRRQLELEVRQLGARVEEEEARLsfEEDRSKKLAAERELRQLTLKIQE 1506
Cdd:TIGR02168  725 SRQISA---------LRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERL--EEAEEELAEAEAEIEELEAQIEQ 793

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1507 LEKRPPALQEKIimeevvklekdpdlerstEALRRELDQEKNRVTELHRECQGLQVQVDLLQK--TKSQEKTIYKEVIRV 1584
Cdd:TIGR02168  794 LKEELKALREAL------------------DELRAELTLLNEEAANLRERLESLERRIAATERrlEDLEEQIEELSEDIE 855

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1585 EKDPVLEGERARVWEI---LNRERAARKGREEDVRSLQERIDRAEALRRSWSREEAELQRARDQASQDCGRLQRQLRELE 1661
Cdd:TIGR02168  856 SLAAEIEELEELIEELeseLEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLE 935

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*....
gi 1907079978 1662 QQKQQKARQLQEEGRL-------LSQKTESERQKAAQRsqaVTQLEAAI 1703
Cdd:TIGR02168  936 VRIDNLQERLSEEYSLtleeaeaLENKIEDDEEEARRR---LKRLENKI 981
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 1916-1954 5.61e-10

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 56.18  E-value: 5.61e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1907079978 1916 LLEAQAATGGIVDLLSRERYSVHKAVERGLIENTSTQRL 1954
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
SPEC super family cl02488
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 228-358 3.03e-07

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


The actual alignment was detected with superfamily member cd00176:

Pssm-ID: 413338 [Multi-domain]  Cd Length: 213  Bit Score: 53.22  E-value: 3.03e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  228 LYTHLQGCTKQLSALADQQGRILQQDwsDLMPDPAGVRREYEHFK--QHELLAQERSINQLEDDADRMVELGHPAIGPIQ 305
Cdd:cd00176      1 KLQQFLRDADELEAWLSEKEELLSST--DYGDDLESVEALLKKHEalEAELAAHEERVEALNELGEQLIEEGHPDAEEIQ 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1907079978  306 VHQEALKMEWQNFLNLCICQESQLQRVEDYRRFQEEADSVSQTLAKLSSNLDT 358
Cdd:cd00176     79 ERLEELNQRWEELRELAEERRQRLEEALDLQQFFRDADDLEQWLEEKEAALAS 131
PLEC smart00250
Plectin repeat;
1952-1989 3.21e-07

Plectin repeat;


:

Pssm-ID: 197605  Cd Length: 38  Bit Score: 48.25  E-value: 3.21e-07
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1907079978  1952 QRLLNAQKAFTGIEDPVTRKRLSVGEAIQKGWMPQESV 1989
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
YhaN super family cl34808
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
694-1075 3.70e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


The actual alignment was detected with superfamily member COG4717:

Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 52.08  E-value: 3.70e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  694 LEKQIQEADRVIQGFEAALALEGPVPEGSgALQERVSELQRQRKELLQQQACVLGLHRQLKATEHACSALQNNFQEFCQD 773
Cdd:COG4717    107 LEAELEELREELEKLEKLLQLLPLYQELE-ALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQ 185

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  774 L-PRQQRQVRALTDRYHAVGDQLDLREKIVQDASLTYQQLRNSRDNLSSWLEQLPHHR---------------------- 830
Cdd:COG4717    186 LsLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEErlkearlllliaaallallglg 265

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  831 VQPSDGPSQISYKLQAQKRLI----------QEILGREQDQATVSRLTRDLQEALQDYELQADTYRCSLEPALAVSAPKR 900
Cdd:COG4717    266 GSLLSLILTIAGVLFLVLGLLallflllareKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDR 345

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  901 LRviSLQESIQAQEKNLAKAYTEVAAAEQQQLRQL-------EFAKKMLRKKELDEDIQAIHSARQ-----GSGSPAHAR 968
Cdd:COG4717    346 IE--ELQELLREAEELEEELQLEELEQEIAALLAEagvedeeELRAALEQAEEYQELKEELEELEEqleelLGELEELLE 423

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  969 TAESEVLKTQLEEERKRVAEVQRDLEEQRQRLLQLRTQqpVARLEEKEVVEfyrdpQLESNLSQAASRVEEEGKRRARLQ 1048
Cdd:COG4717    424 ALDEEELEEELEELEEELEELEEELEELREELAELEAE--LEQLEEDGELA-----ELLQELEELKAELRELAEEWAALK 496

                          410       420
                   ....*....|....*....|....*..
gi 1907079978 1049 AELEAVAQkvvHLEGKRKTMQPHLLTK 1075
Cdd:COG4717    497 LALELLEE---AREEYREERLPPVLER 520
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 1995-2030 2.06e-05

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 43.09  E-value: 2.06e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907079978 1995 VQHLTGGLIDPKRTGRIPVPQAVLCGMISEDLGQLL 2030
Cdd:pfam00681    4 AQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 1746-1774 5.48e-04

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 39.23  E-value: 5.48e-04
                           10        20
                   ....*....|....*....|....*....
gi 1907079978 1746 ILEPETGNDMSPYEAYKRGVIDRGQYLQL 1774
Cdd:pfam00681   11 IIDPVTGERLSVEEAVKRGLIDPETAQKL 39
PLEC smart00250
Plectin repeat;
1878-1913 1.17e-03

Plectin repeat;


:

Pssm-ID: 197605  Cd Length: 38  Bit Score: 38.23  E-value: 1.17e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1907079978  1878 LTEDSFPIAGIYDTTTDNKCSIKAAVAKNMLDPITG 1913
Cdd:smart00250    3 LLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
 
Name Accession Description Interval E-value
SH3_10 pfam17902
SH3 domain; This entry represents an SH3 domain.
 404-468 7.87e-25

SH3 domain; This entry represents an SH3 domain.


Pssm-ID: 407754  Cd Length: 65  Bit Score: 99.26  E-value: 7.87e-25
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907079978  404 PLPQRRNPSKQPLHVDSICDWDSGEVQLLRGERYTLKDNADPYTWLVQGPGGETKSAPAACLCIP 468
Cdd:pfam17902    1 PLKQRRSPVTRPIPVKALCDYKQGEVTVEKGEECTLLDNSDREKWKVQTSSGVEKLVPSVCFLIP 65
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 908-1703 2.61e-24

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 112.07  E-value: 2.61e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  908 ESIQAQEKnLAKAYTEVaaaeQQQLRQLEFAKKMLRKKELDEDIQAIHSARQGSGSPAHARTAESEVLKTQLEEERKRVA 987
Cdd:TIGR02168  203 KSLERQAE-KAERYKEL----KAELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVS 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  988 EVQRDLEEQRQRLLQLRTQQpvARLEEKEVVEFYRDPQLESNLSQAASRVEEEGKRRARLQAELEAVAQKVVHLEGKRKT 1067
Cdd:TIGR02168  278 ELEEEIEELQKELYALANEI--SRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELES 355

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1068 MQPHLLTKEVTQIERDPG---LDSQVTQLHSEMQRLRGENGVLTARLEELKDELLALEQKEMNVKEKVVVKEVVKVEKDL 1144
Cdd:TIGR02168  356 LEAELEELEAELEELESRleeLEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAEL 435

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1145 EMVKAA-QTLRLQIEEDAARRKGAKETVAKIQARIKDLEQAISSVEpkvivkevkkveqdpgllKEASRLRSLLEeeknn 1223
Cdd:TIGR02168  436 KELQAElEELEEELEELQEELERLEEALEELREELEEAEQALDAAE------------------RELAQLQARLD----- 492

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1224 nvALARELQELQEKYR----VVEKQKPKVQLQERVSEIFQVLPETEQEIRR-LRAQLQE-TGSKKSGVEQEVEKLLP--- 1294
Cdd:TIGR02168  493 --SLERLQENLEGFSEgvkaLLKNQSGLSGILGVLSELISVDEGYEAAIEAaLGGRLQAvVVENLNAAKKAIAFLKQnel 570

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1295 ------ELEVLRAQKPVVEYKEVTQEV-------VRHEKNPEVLRE-----------IDRLKAQLNELVNTNGRsqEQLI 1350
Cdd:TIGR02168  571 grvtflPLDSIKGTEIQGNDREILKNIegflgvaKDLVKFDPKLRKalsyllggvlvVDDLDNALELAKKLRPG--YRIV 648

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1351 RLQGERDEWK----RERSKVETKMVSKEVVRHEkdpvLEKEAERLRQEVREAVQRRRATEDAVYELQNKLLLLERRRPEE 1426
Cdd:TIGR02168  649 TLDGDLVRPGgvitGGSAKTNSSILERRREIEE----LEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEEL 724

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1427 QIVVQEvvvtqkdpkLREEHSRLSRSLDEEVGRRRQLELEVRQLGARVEEEEARLsfEEDRSKKLAAERELRQLTLKIQE 1506
Cdd:TIGR02168  725 SRQISA---------LRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERL--EEAEEELAEAEAEIEELEAQIEQ 793

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1507 LEKRPPALQEKIimeevvklekdpdlerstEALRRELDQEKNRVTELHRECQGLQVQVDLLQK--TKSQEKTIYKEVIRV 1584
Cdd:TIGR02168  794 LKEELKALREAL------------------DELRAELTLLNEEAANLRERLESLERRIAATERrlEDLEEQIEELSEDIE 855

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1585 EKDPVLEGERARVWEI---LNRERAARKGREEDVRSLQERIDRAEALRRSWSREEAELQRARDQASQDCGRLQRQLRELE 1661
Cdd:TIGR02168  856 SLAAEIEELEELIEELeseLEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLE 935

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*....
gi 1907079978 1662 QQKQQKARQLQEEGRL-------LSQKTESERQKAAQRsqaVTQLEAAI 1703
Cdd:TIGR02168  936 VRIDNLQERLSEEYSLtleeaeaLENKIEDDEEEARRR---LKRLENKI 981
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1154-1702 2.20e-20

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 98.86  E-value: 2.20e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1154 RLQIEEDAARRKGAKETVAKIQARIKDLEQAISSvepkvivkevkkveqdpgLLKEASRLRSLLEEEKNNNVALARELQE 1233
Cdd:COG1196    224 ELEAELLLLKLRELEAELEELEAELEELEAELEE------------------LEAELAELEAELEELRLELEELELELEE 285

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1234 LQEKYRVVEKQKPKVQ-----LQERVSEIFQVLPETEQEIRRLRAQLQETGSKKSGVEQEVEKLLPELEVLRAQKPVVEY 1308
Cdd:COG1196    286 AQAEEYELLAELARLEqdiarLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEE 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1309 KEVTQEVVRHEKNPEVLREIDRLKAQLNELVNTNGRSQEQLIRLQGERDEWKRERSKVETKMVSKEVVRHEKDPVLEKEA 1388
Cdd:COG1196    366 ALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALE 445

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1389 ER-------------LRQEVREAVQRRRATEDAVYELQNKLLLLERRRPEEQIVVQEVVVTQKDPKLREEHSRLSRsLDE 1455
Cdd:COG1196    446 EAaeeeaeleeeeeaLLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRG-LAG 524

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1456 EVGRRRQLELEVRQ---------LGARVEEEEARLSFEEDRSKKLAAERELRQLTLKIQELEKRPPALQEKIIMEEVVKL 1526
Cdd:COG1196    525 AVAVLIGVEAAYEAaleaalaaaLQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLV 604

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1527 EKDPDLERSTEALRRELDQEKNRVTELHRECQGLQVQVDLLQKTKSQEKTIykevirVEKDPVLEGERARvwEILNRERA 1606
Cdd:COG1196    605 ASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEG------GSAGGSLTGGSRR--ELLAALLE 676

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1607 ARKGREEDVRSLQERIDRAEALRRSWSREEAELQRARDQASQDCGRLQRQLRELEQQKQQKARQLQEEGRLLSQKTESER 1686
Cdd:COG1196    677 AEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEEL 756

                          570
                   ....*....|....*.
gi 1907079978 1687 QKAAQRSQAVTQLEAA 1702
Cdd:COG1196    757 PEPPDLEELERELERL 772
PTZ00121 PTZ00121
MAEBL; Provisional
 1145-1758 4.69e-18

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 91.74  E-value: 4.69e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1145 EMVKAAQTLRLQIEEDAARRKGAKETVAKIQARIKDLEQAISSVEPKVIVKEVKKVEQDPGLLKEASRLRSLLEEEKNNN 1224
Cdd:PTZ00121  1209 EEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEE 1288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1225 VALARELQELQEKyRVVEKQKPKVQLQERVSEIFQVLPETEQEIRRLRAQLQETGSKKSGVEQEVEKLLPELEVLRAQKP 1304
Cdd:PTZ00121  1289 KKKADEAKKAEEK-KKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAE 1367

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1305 VVEYK--EVTQEVVRHEKNPEVLREIDRLKAQLNElvntNGRSQEQLIRLQGERDEWKRERSKVETKMVSKEVVRHEKDP 1382
Cdd:PTZ00121  1368 AAEKKkeEAKKKADAAKKKAEEKKKADEAKKKAEE----DKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEA 1443

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1383 VLEKEAERLRQEVREAVQRRRATEDAVYELQNKLLLLERRRPEEQIVVQEVVVTQKDP-KLREEHSRLSRSLDEEVGRRR 1461
Cdd:PTZ00121  1444 KKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEaKKAAEAKKKADEAKKAEEAKK 1523

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1462 QLELEVRQLGARVEE----EEARLSFEEDRSKKLAAERELRQLTLKIQELEKRPPALQ--------EKIIMEEVVKLEKD 1529
Cdd:PTZ00121  1524 ADEAKKAEEAKKADEakkaEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRkaeeakkaEEARIEEVMKLYEE 1603

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1530 PDLERSTEAlrRELDQEKNRVTELHREcQGLQVQVDLLQKTKSQEKTIYKEV--------IRVEKDPVLEGERARVWEIL 1601
Cdd:PTZ00121  1604 EKKMKAEEA--KKAEEAKIKAEELKKA-EEEKKKVEQLKKKEAEEKKKAEELkkaeeenkIKAAEEAKKAEEDKKKAEEA 1680

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1602 NRERAARKGREEDVRSLQERIDRAEALRRSWSREEAELQRARDQASQDCGRLQRQLRELEQQKqQKARQLQEEgrllsqk 1681
Cdd:PTZ00121  1681 KKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDK-KKAEEAKKD------- 1752

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907079978 1682 tESERQKAAQRSQAVTQLEAAILQEKDKIYEKERTLRDLHTKVSREELNQETQTRETNLStkicilepETGNDMSPY 1758
Cdd:PTZ00121  1753 -EEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANII--------EGGKEGNLV 1820
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 976-1673 2.36e-11

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 69.43  E-value: 2.36e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  976 KTQLEEERKRVAEVQRDLEEQRQRLL-QLRTQQPV-ARLEEKEVVEFYRDPQLESNLSQAASRVEEEGKRRARLQAElea 1053
Cdd:pfam01576   21 QQKAESELKELEKKHQQLCEEKNALQeQLQAETELcAEAEEMRARLAARKQELEEILHELESRLEEEEERSQQLQNE--- 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1054 vaqkvvhlegkRKTMQPHLLTkevtqierdpgLDSQVTQLHSEMQRLRGENGVLTARLEELKDELLALE------QKEMN 1127
Cdd:pfam01576   98 -----------KKKMQQHIQD-----------LEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEdqnsklSKERK 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1128 VKEKVVVKEVVKVEKDLEMVKAAQTLRLQIEedaarrkgakETVAKIQARIKDLEQAISSVEPKVIVKEVKKVEqdpgLL 1207
Cdd:pfam01576  156 LLEERISEFTSNLAEEEEKAKSLSKLKNKHE----------AMISDLEERLKKEEKGRQELEKAKRKLEGESTD----LQ 221

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1208 KEASRLRSLLEEEKNNNVALARELQELQEkyRVVEKQKPKVQLQERVSEIFQVLPETEQEIRRLRAQLQETGSKKSGVEQ 1287
Cdd:pfam01576  222 EQIAELQAQIAELRAQLAKKEEELQAALA--RLEEETAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQRRDLGE 299

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1288 EVEKLLPELE----VLRAQKPVVEYKEvtQEVVRHEKNPEvlREIDRLKAQLNELvntNGRSQEQLIRLQGERDEWKRER 1363
Cdd:pfam01576  300 ELEALKTELEdtldTTAAQQELRSKRE--QEVTELKKALE--EETRSHEAQLQEM---RQKHTQALEELTEQLEQAKRNK 372

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1364 SKVETKMVSKEVVRHEkdpvLEKEAERLRQEVREAVQRRRATEDAVYELQNKLLLLERRRPEEQIVVQE----------- 1432
Cdd:pfam01576  373 ANLEKAKQALESENAE----LQAELRTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKlqselesvssl 448

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1433 -VVVTQKDPKLREEHSRLSRSL-------DEEVGRRRQLELEVRQLgarvEEEEARL--SFEEDRSKKLAAERELRQLTL 1502
Cdd:pfam01576  449 lNEAEGKNIKLSKDVSSLESQLqdtqellQEETRQKLNLSTRLRQL----EDERNSLqeQLEEEEEAKRNVERQLSTLQA 524

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1503 KIQELEKRppaLQEKIIMEEVVKlEKDPDLERSTEALRRELDQEKNRVTELHRECQGLQVQVDLLQKTKSQEKTIYKEVI 1582
Cdd:pfam01576  525 QLSDMKKK---LEEDAGTLEALE-EGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLE 600

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1583 RVEK--DPVLEGERARVWEILN-RERAARKGREEDVRSL---------QERIDRAEALRRSWSREEAELQRARDQASQDC 1650
Cdd:pfam01576  601 KKQKkfDQMLAEEKAISARYAEeRDRAEAEAREKETRALslaraleeaLEAKEELERTNKQLRAEMEDLVSSKDDVGKNV 680

                          730       740
                   ....*....|....*....|...
gi 1907079978 1651 GRLQRQLRELEQQKQQKARQLQE 1673
Cdd:pfam01576  681 HELERSKRALEQQVEEMKTQLEE 703
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 1916-1954 5.61e-10

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 56.18  E-value: 5.61e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1907079978 1916 LLEAQAATGGIVDLLSRERYSVHKAVERGLIENTSTQRL 1954
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 228-358 3.03e-07

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 53.22  E-value: 3.03e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  228 LYTHLQGCTKQLSALADQQGRILQQDwsDLMPDPAGVRREYEHFK--QHELLAQERSINQLEDDADRMVELGHPAIGPIQ 305
Cdd:cd00176      1 KLQQFLRDADELEAWLSEKEELLSST--DYGDDLESVEALLKKHEalEAELAAHEERVEALNELGEQLIEEGHPDAEEIQ 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1907079978  306 VHQEALKMEWQNFLNLCICQESQLQRVEDYRRFQEEADSVSQTLAKLSSNLDT 358
Cdd:cd00176     79 ERLEELNQRWEELRELAEERRQRLEEALDLQQFFRDADDLEQWLEEKEAALAS 131
PLEC smart00250
Plectin repeat;
1952-1989 3.21e-07

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 48.25  E-value: 3.21e-07
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1907079978  1952 QRLLNAQKAFTGIEDPVTRKRLSVGEAIQKGWMPQESV 1989
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
1914-1947 9.45e-07

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 47.09  E-value: 9.45e-07
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1907079978  1914 QKLLEAQAATGGIVDLLSRERYSVHKAVERGLIE 1947
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLID 34
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
694-1075 3.70e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 52.08  E-value: 3.70e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  694 LEKQIQEADRVIQGFEAALALEGPVPEGSgALQERVSELQRQRKELLQQQACVLGLHRQLKATEHACSALQNNFQEFCQD 773
Cdd:COG4717    107 LEAELEELREELEKLEKLLQLLPLYQELE-ALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQ 185

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  774 L-PRQQRQVRALTDRYHAVGDQLDLREKIVQDASLTYQQLRNSRDNLSSWLEQLPHHR---------------------- 830
Cdd:COG4717    186 LsLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEErlkearlllliaaallallglg 265

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  831 VQPSDGPSQISYKLQAQKRLI----------QEILGREQDQATVSRLTRDLQEALQDYELQADTYRCSLEPALAVSAPKR 900
Cdd:COG4717    266 GSLLSLILTIAGVLFLVLGLLallflllareKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDR 345

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  901 LRviSLQESIQAQEKNLAKAYTEVAAAEQQQLRQL-------EFAKKMLRKKELDEDIQAIHSARQ-----GSGSPAHAR 968
Cdd:COG4717    346 IE--ELQELLREAEELEEELQLEELEQEIAALLAEagvedeeELRAALEQAEEYQELKEELEELEEqleelLGELEELLE 423

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  969 TAESEVLKTQLEEERKRVAEVQRDLEEQRQRLLQLRTQqpVARLEEKEVVEfyrdpQLESNLSQAASRVEEEGKRRARLQ 1048
Cdd:COG4717    424 ALDEEELEEELEELEEELEELEEELEELREELAELEAE--LEQLEEDGELA-----ELLQELEELKAELRELAEEWAALK 496

                          410       420
                   ....*....|....*....|....*..
gi 1907079978 1049 AELEAVAQkvvHLEGKRKTMQPHLLTK 1075
Cdd:COG4717    497 LALELLEE---AREEYREERLPPVLER 520
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 1995-2030 2.06e-05

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 43.09  E-value: 2.06e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907079978 1995 VQHLTGGLIDPKRTGRIPVPQAVLCGMISEDLGQLL 2030
Cdd:pfam00681    4 AQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
SPEC smart00150
Spectrin repeats;
256-330 1.33e-04

Spectrin repeats;


Pssm-ID: 197544 [Multi-domain]  Cd Length: 101  Bit Score: 43.09  E-value: 1.33e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907079978   256 DLMPDPAGVRREYEHFK--QHELLAQERSINQLEDDADRMVELGHPAIGPIQVHQEALKMEWQNFLNLCICQESQLQ 330
Cdd:smart00150   25 DLGKDLESVEALLKKHEafEAELEAHEERVEALNELGEQLIEEGHPDAEEIEERLEELNERWEELKELAEERRQKLE 101
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 1746-1774 5.48e-04

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 39.23  E-value: 5.48e-04
                           10        20
                   ....*....|....*....|....*....
gi 1907079978 1746 ILEPETGNDMSPYEAYKRGVIDRGQYLQL 1774
Cdd:pfam00681   11 IIDPVTGERLSVEEAVKRGLIDPETAQKL 39
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 582-1126 1.07e-03

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 44.19  E-value: 1.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  582 QTLLSQMTQLDGDLGQIERQVLSWARSPLSQSSSLKDLEGRIHSCEGTAQRLQSLGAEKEAAQQEceAFLSTKPTGSAAL 661
Cdd:TIGR00618  385 QQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITC--TAQCEKLEKIHLQ 462

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  662 QLPVVLNSVKNRYNDVQSLCHLYGEKAKAALGLEKQIQEADRVIQGFEAALALEGPVPEGSGALQERVSELQRQRKELLQ 741
Cdd:TIGR00618  463 ESAQSLKEREQQLQTKEQIHLQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDNPGPLTRRMQRGEQTYAQLET 542

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  742 QqacvlglhrqLKATEHACSALQNNFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLREKIVQDasltyqqlrnsrdnLSS 821
Cdd:TIGR00618  543 S----------EEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVR--------------LQD 598

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  822 WLEQLPHHRVQpsdgpsqisyklqaqKRLIQEILGREqdqatvsrltrdLQEALQDYELQADTYRCSLEPALAVSAPKRL 901
Cdd:TIGR00618  599 LTEKLSEAEDM---------------LACEQHALLRK------------LQPEQDLQDVRLHLQQCSQELALKLTALHAL 651

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  902 RVISLQE-------SIQAQEKNLAKAYTEVAAAEQQQLRQLEFAKKMLRKKelDEDIQAIHSARQGSGSPAHARTAESEV 974
Cdd:TIGR00618  652 QLTLTQErvrehalSIRVLPKELLASRQLALQKMQSEKEQLTYWKEMLAQC--QTLLRELETHIEEYDREFNEIENASSS 729

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  975 LKTQLEEERKRVAEVQRDLEEQRQRLLQLRTQQPvARLEEKEVVEFYRDPQLESNLSQAASRVEEEGKRRARLQAELEAV 1054
Cdd:TIGR00618  730 LGSDLAAREDALNQSLKELMHQARTVLKARTEAH-FNNNEEVTAALQTGAELSHLAAEIQFFNRLREEDTHLLKTLEAEI 808

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907079978 1055 AQKVVHLEGKRkTMQPHLLTKEVTQierdpgLDSQVTQLHSEMQRLRGENGVLTARLEELkdELLALEQKEM 1126
Cdd:TIGR00618  809 GQEIPSDEDIL-NLQCETLVQEEEQ------FLSRLEEKSATLGEITHQLLKYEECSKQL--AQLTQEQAKI 871
PLEC smart00250
Plectin repeat;
1878-1913 1.17e-03

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 38.23  E-value: 1.17e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1907079978  1878 LTEDSFPIAGIYDTTTDNKCSIKAAVAKNMLDPITG 1913
Cdd:smart00250    3 LLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 1211-1591 2.47e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 43.08  E-value: 2.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1211 SRLRSLLEEEKN-NNVALARELQELQEKY---RVVEKQKPKVQLQERV-SEIFQVLPETEQEIRRLRAQLQETGSKksgV 1285
Cdd:NF033838    72 SEIQKSLDKRKHtQNVALNKKLSDIKTEYlyeLNVLKEKSEAELTSKTkKELDAAFEQFKKDTLEPGKKVAEATKK---V 148

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1286 EQEVEKLLPELEVLRAQKPVVEYKevTQEVVRHEKNPEVLR-EIDRLKAQLNElvntngrsqeqlirlqgERDEWKRERS 1364
Cdd:NF033838   149 EEAEKKAKDQKEEDRRNYPTNTYK--TLELEIAESDVEVKKaELELVKEEAKE-----------------PRDEEKIKQA 209

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1365 KVETKMVSKEVVRHEKDPVLEKEAERLRQEVREAVQRRRATEDAVYELQNKLllleRRRPEEQIVVQEVVVTQKDPKLRE 1444
Cdd:NF033838   210 KAKVESKKAEATRLEKIKTDREKAEEEAKRRADAKLKEAVEKNVATSEQDKP----KRRAKRGVLGEPATPDKKENDAKS 285

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1445 EHSrlsrSLDEEVGRRRQLELEVRQLGA--RVEEEE--ARLSFEEDRskklaaeRELRQLTLKIQELEkrppalqekiIM 1520
Cdd:NF033838   286 SDS----SVGEETLPSPSLKPEKKVAEAekKVEEAKkkAKDQKEEDR-------RNYPTNTYKTLELE----------IA 344

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907079978 1521 EEVVKLeKDPDLERSTEALRRELDQEKnrVTELHRECQGLQVQVDLLQKTKSQEKTIYKEVIR--VEKDPVLE 1591
Cdd:NF033838   345 ESDVKV-KEAELELVKEEAKEPRNEEK--IKQAKAKVESKKAEATRLEKIKTDRKKAEEEAKRkaAEEDKVKE 414
RGS_LARG cd08754
Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine ...
 637-781 4.75e-03

Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG); The RGS domain is an essential part of the leukemia-associated RhoGEF protein (LARG), a member of the RhoGEF (Rho guanine nucleotide exchange factor) subfamily of the RGS protein family. The RhoGEFs are peripheral membrane proteins that regulate essential cellular processes, including cell shape, cell migration, cell cycle progression of cells, and gene transcription by linking signals from heterotrimeric G-alpha12/13 protein-coupled receptors to Rho GTPase activation, leading to various cellular responses, such as actin reorganization and gene expression. The RhoGEF subfamily includes p115RhoGEF, LARG, PDZ-RhoGEF, and its rat specific splice variant GTRAP48. The RGS domain of RhoGEFs has very little sequence similarity with the canonical RGS domain of the RGS proteins and is often refered to as RH (RGS Homology) domain. In addition to being a G-alpha13 effector, the LARG protein also functions as a GTPase-activating protein (GAP) for G-alpha13. RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development.


Pssm-ID: 188708  Cd Length: 222  Bit Score: 40.75  E-value: 4.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  637 GAEKEAAQQECEAFLSTKPTGSAALQLPVVLNSVKNRYNDVQSLCHLYGEKAKaalglEKQIQEADRVIQGF-----EAA 711
Cdd:cd08754     11 PTESEQINGQCSCFQNIELLKSRPAHLAVFLHHVVSQFDPAALLCYLYADLYK-----QTNSKETRRVFLEFnqfflDRA 85

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907079978  712 LALEGPVPEgsgalqERVSELQRQRKELLQQQacvlgLHRQLKAT--EHACSALQNNFQEFcqdlpRQQRQV 781
Cdd:cd08754     86 ANLKVPVPD------EVSLDLEKRRPELIPEE-----LHRHYIQTmqERVSPEVQRNLEDF-----RQKRSM 141
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 1618-1714 9.87e-03

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 40.25  E-value: 9.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1618 LQERIDRAEALRRSWS------REEAELQRARDQASQDCGRLQRQLRELEQQKQQKARQLQEEGRLLSQKTESERQKAAQ 1691
Cdd:cd16269    176 LQSKEAEAEAILQADQaltekeKEIEAERAKAEAAEQERKLLEEQQRELEQKLEDQERSYEEHLRQLKEKMEEERENLLK 255

                           90       100
                   ....*....|....*....|...
gi 1907079978 1692 RSQAVTQLEaaiLQEKDKIYEKE 1714
Cdd:cd16269    256 EQERALESK---LKEQEALLEEG 275
 
Name Accession Description Interval E-value
SH3_10 pfam17902
SH3 domain; This entry represents an SH3 domain.
 404-468 7.87e-25

SH3 domain; This entry represents an SH3 domain.


Pssm-ID: 407754  Cd Length: 65  Bit Score: 99.26  E-value: 7.87e-25
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907079978  404 PLPQRRNPSKQPLHVDSICDWDSGEVQLLRGERYTLKDNADPYTWLVQGPGGETKSAPAACLCIP 468
Cdd:pfam17902    1 PLKQRRSPVTRPIPVKALCDYKQGEVTVEKGEECTLLDNSDREKWKVQTSSGVEKLVPSVCFLIP 65
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 908-1703 2.61e-24

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 112.07  E-value: 2.61e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  908 ESIQAQEKnLAKAYTEVaaaeQQQLRQLEFAKKMLRKKELDEDIQAIHSARQGSGSPAHARTAESEVLKTQLEEERKRVA 987
Cdd:TIGR02168  203 KSLERQAE-KAERYKEL----KAELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVS 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  988 EVQRDLEEQRQRLLQLRTQQpvARLEEKEVVEFYRDPQLESNLSQAASRVEEEGKRRARLQAELEAVAQKVVHLEGKRKT 1067
Cdd:TIGR02168  278 ELEEEIEELQKELYALANEI--SRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELES 355

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1068 MQPHLLTKEVTQIERDPG---LDSQVTQLHSEMQRLRGENGVLTARLEELKDELLALEQKEMNVKEKVVVKEVVKVEKDL 1144
Cdd:TIGR02168  356 LEAELEELEAELEELESRleeLEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAEL 435

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1145 EMVKAA-QTLRLQIEEDAARRKGAKETVAKIQARIKDLEQAISSVEpkvivkevkkveqdpgllKEASRLRSLLEeeknn 1223
Cdd:TIGR02168  436 KELQAElEELEEELEELQEELERLEEALEELREELEEAEQALDAAE------------------RELAQLQARLD----- 492

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1224 nvALARELQELQEKYR----VVEKQKPKVQLQERVSEIFQVLPETEQEIRR-LRAQLQE-TGSKKSGVEQEVEKLLP--- 1294
Cdd:TIGR02168  493 --SLERLQENLEGFSEgvkaLLKNQSGLSGILGVLSELISVDEGYEAAIEAaLGGRLQAvVVENLNAAKKAIAFLKQnel 570

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1295 ------ELEVLRAQKPVVEYKEVTQEV-------VRHEKNPEVLRE-----------IDRLKAQLNELVNTNGRsqEQLI 1350
Cdd:TIGR02168  571 grvtflPLDSIKGTEIQGNDREILKNIegflgvaKDLVKFDPKLRKalsyllggvlvVDDLDNALELAKKLRPG--YRIV 648

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1351 RLQGERDEWK----RERSKVETKMVSKEVVRHEkdpvLEKEAERLRQEVREAVQRRRATEDAVYELQNKLLLLERRRPEE 1426
Cdd:TIGR02168  649 TLDGDLVRPGgvitGGSAKTNSSILERRREIEE----LEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEEL 724

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1427 QIVVQEvvvtqkdpkLREEHSRLSRSLDEEVGRRRQLELEVRQLGARVEEEEARLsfEEDRSKKLAAERELRQLTLKIQE 1506
Cdd:TIGR02168  725 SRQISA---------LRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERL--EEAEEELAEAEAEIEELEAQIEQ 793

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1507 LEKRPPALQEKIimeevvklekdpdlerstEALRRELDQEKNRVTELHRECQGLQVQVDLLQK--TKSQEKTIYKEVIRV 1584
Cdd:TIGR02168  794 LKEELKALREAL------------------DELRAELTLLNEEAANLRERLESLERRIAATERrlEDLEEQIEELSEDIE 855

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1585 EKDPVLEGERARVWEI---LNRERAARKGREEDVRSLQERIDRAEALRRSWSREEAELQRARDQASQDCGRLQRQLRELE 1661
Cdd:TIGR02168  856 SLAAEIEELEELIEELeseLEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLE 935

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*....
gi 1907079978 1662 QQKQQKARQLQEEGRL-------LSQKTESERQKAAQRsqaVTQLEAAI 1703
Cdd:TIGR02168  936 VRIDNLQERLSEEYSLtleeaeaLENKIEDDEEEARRR---LKRLENKI 981
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1154-1702 2.20e-20

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 98.86  E-value: 2.20e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1154 RLQIEEDAARRKGAKETVAKIQARIKDLEQAISSvepkvivkevkkveqdpgLLKEASRLRSLLEEEKNNNVALARELQE 1233
Cdd:COG1196    224 ELEAELLLLKLRELEAELEELEAELEELEAELEE------------------LEAELAELEAELEELRLELEELELELEE 285

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1234 LQEKYRVVEKQKPKVQ-----LQERVSEIFQVLPETEQEIRRLRAQLQETGSKKSGVEQEVEKLLPELEVLRAQKPVVEY 1308
Cdd:COG1196    286 AQAEEYELLAELARLEqdiarLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEE 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1309 KEVTQEVVRHEKNPEVLREIDRLKAQLNELVNTNGRSQEQLIRLQGERDEWKRERSKVETKMVSKEVVRHEKDPVLEKEA 1388
Cdd:COG1196    366 ALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALE 445

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1389 ER-------------LRQEVREAVQRRRATEDAVYELQNKLLLLERRRPEEQIVVQEVVVTQKDPKLREEHSRLSRsLDE 1455
Cdd:COG1196    446 EAaeeeaeleeeeeaLLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRG-LAG 524

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1456 EVGRRRQLELEVRQ---------LGARVEEEEARLSFEEDRSKKLAAERELRQLTLKIQELEKRPPALQEKIIMEEVVKL 1526
Cdd:COG1196    525 AVAVLIGVEAAYEAaleaalaaaLQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLV 604

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1527 EKDPDLERSTEALRRELDQEKNRVTELHRECQGLQVQVDLLQKTKSQEKTIykevirVEKDPVLEGERARvwEILNRERA 1606
Cdd:COG1196    605 ASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEG------GSAGGSLTGGSRR--ELLAALLE 676

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1607 ARKGREEDVRSLQERIDRAEALRRSWSREEAELQRARDQASQDCGRLQRQLRELEQQKQQKARQLQEEGRLLSQKTESER 1686
Cdd:COG1196    677 AEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEEL 756

                          570
                   ....*....|....*.
gi 1907079978 1687 QKAAQRSQAVTQLEAA 1702
Cdd:COG1196    757 PEPPDLEELERELERL 772
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 871-1596 4.61e-19

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 94.74  E-value: 4.61e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  871 LQEALQDYELQADTYRCSLEPALAVSAPKRLRVISLQESIQAQEKNLAKAYTEVAAAEQQqLRQLEFAKKMLRK--KELD 948
Cdd:TIGR02168  244 LQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQ-KQILRERLANLERqlEELE 322

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  949 EDIQAIHSARQGSGSPAHARTAESEVLKTQLEEERKRVAEVQRDLEEQRQRLLQLRTQqpvARLEEKEVVEFYRDPQLES 1028
Cdd:TIGR02168  323 AQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQ---LETLRSKVAQLELQIASLN 399

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1029 N-LSQAASRVEEEGKRRARLQAELEAVAQKVVHLE--------GKRKTMQPHLLTKEVTQIERDPGLDSQVTQLHSEMQR 1099
Cdd:TIGR02168  400 NeIERLEARLERLEDRRERLQQEIEELLKKLEEAElkelqaelEELEEELEELQEELERLEEALEELREELEEAEQALDA 479

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1100 LRGENGVLTARLEELKDELLALEQKEMNVKEKVVVKEVVKVEKDL--EMVKAAQTLRLQIEEDAARRKGA-----KETVA 1172
Cdd:TIGR02168  480 AERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVlsELISVDEGYEAAIEAALGGRLQAvvvenLNAAK 559

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1173 KIQARIKDLEQAISSVEP-------KVIVKEVKKVEQDPGLLKEASRLRSLLEEEKN------------NNVALARELQ- 1232
Cdd:TIGR02168  560 KAIAFLKQNELGRVTFLPldsikgtEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKalsyllggvlvvDDLDNALELAk 639

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1233 ELQEKYRVVEKQKPKV-----QLQERVSEIFQVLpETEQEIRRLRAQLQETGSKKSGVEQEVEKLLPELEVLRAQKPVVE 1307
Cdd:TIGR02168  640 KLRPGYRIVTLDGDLVrpggvITGGSAKTNSSIL-ERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLR 718

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1308 YKEVTQEvvrheknpevlREIDRLKAQLNELVNTNGRSQEQLIRLQGERDEWKRERSKVETKMVSKEVVRHEkdpvLEKE 1387
Cdd:TIGR02168  719 KELEELS-----------RQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAE----AEAE 783

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1388 AERLRQEVREAVQRRRATEDAVYELQNKLLLLERRRpeeqivvqeVVVTQKDPKLREEHSRLSRSLDEEVGRRRQLELEV 1467
Cdd:TIGR02168  784 IEELEAQIEQLKEELKALREALDELRAELTLLNEEA---------ANLRERLESLERRIAATERRLEDLEEQIEELSEDI 854

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1468 RQLGARVEEEEARLSFEEDRSKKLAAERELRQLTLKiqELEKRPPALQEKIimeevvklekdPDLERSTEALRRELDQEK 1547
Cdd:TIGR02168  855 ESLAAEIEELEELIEELESELEALLNERASLEEALA--LLRSELEELSEEL-----------RELESKRSELRRELEELR 921

                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1548 NRVTELHRECQGLQVQVD-LLQKTKSQEKTIYKEVIRVEKDPVLEGERAR 1596
Cdd:TIGR02168  922 EKLAQLELRLEGLEVRIDnLQERLSEEYSLTLEEAEALENKIEDDEEEAR 971
PTZ00121 PTZ00121
MAEBL; Provisional
 1145-1758 4.69e-18

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 91.74  E-value: 4.69e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1145 EMVKAAQTLRLQIEEDAARRKGAKETVAKIQARIKDLEQAISSVEPKVIVKEVKKVEQDPGLLKEASRLRSLLEEEKNNN 1224
Cdd:PTZ00121  1209 EEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEE 1288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1225 VALARELQELQEKyRVVEKQKPKVQLQERVSEIFQVLPETEQEIRRLRAQLQETGSKKSGVEQEVEKLLPELEVLRAQKP 1304
Cdd:PTZ00121  1289 KKKADEAKKAEEK-KKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAE 1367

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1305 VVEYK--EVTQEVVRHEKNPEVLREIDRLKAQLNElvntNGRSQEQLIRLQGERDEWKRERSKVETKMVSKEVVRHEKDP 1382
Cdd:PTZ00121  1368 AAEKKkeEAKKKADAAKKKAEEKKKADEAKKKAEE----DKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEA 1443

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1383 VLEKEAERLRQEVREAVQRRRATEDAVYELQNKLLLLERRRPEEQIVVQEVVVTQKDP-KLREEHSRLSRSLDEEVGRRR 1461
Cdd:PTZ00121  1444 KKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEaKKAAEAKKKADEAKKAEEAKK 1523

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1462 QLELEVRQLGARVEE----EEARLSFEEDRSKKLAAERELRQLTLKIQELEKRPPALQ--------EKIIMEEVVKLEKD 1529
Cdd:PTZ00121  1524 ADEAKKAEEAKKADEakkaEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRkaeeakkaEEARIEEVMKLYEE 1603

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1530 PDLERSTEAlrRELDQEKNRVTELHREcQGLQVQVDLLQKTKSQEKTIYKEV--------IRVEKDPVLEGERARVWEIL 1601
Cdd:PTZ00121  1604 EKKMKAEEA--KKAEEAKIKAEELKKA-EEEKKKVEQLKKKEAEEKKKAEELkkaeeenkIKAAEEAKKAEEDKKKAEEA 1680

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1602 NRERAARKGREEDVRSLQERIDRAEALRRSWSREEAELQRARDQASQDCGRLQRQLRELEQQKqQKARQLQEEgrllsqk 1681
Cdd:PTZ00121  1681 KKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDK-KKAEEAKKD------- 1752

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907079978 1682 tESERQKAAQRSQAVTQLEAAILQEKDKIYEKERTLRDLHTKVSREELNQETQTRETNLStkicilepETGNDMSPY 1758
Cdd:PTZ00121  1753 -EEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANII--------EGGKEGNLV 1820
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 912-1553 3.05e-17

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 88.46  E-value: 3.05e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  912 AQEKNLAKAYTEVAAAEQQ---QLRQLEFAKKMLRKKELDEDIQAIHSARQGSGSPAHARTAESEVLKTQLEEERKRVAE 988
Cdd:COG1196    206 ERQAEKAERYRELKEELKEleaELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEE 285

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  989 VQRDLEEQRQRLLQLRTQQPVARLEEKEVVEfyRDPQLESNLSQAASRVEEEGKRRARLQAELEAVAQKVVHLEgkrktm 1068
Cdd:COG1196    286 AQAEEYELLAELARLEQDIARLEERRRELEE--RLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAE------ 357

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1069 qphlltkevtqierdpgldsqvTQLHSEMQRLRGENGVLTARLEELKDELLALEQKEmnvkekvvvkevvkvekdlemvK 1148
Cdd:COG1196    358 ----------------------AELAEAEEALLEAEAELAEAEEELEELAEELLEAL----------------------R 393

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1149 AAQTLRLQIEEDAARRKGAKETVAKIQARIKDLEQAISSVEPKVIVKEVKKVEQDPGLLKEASRLRSLLEEEKNNNVALA 1228
Cdd:COG1196    394 AAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAA 473

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1229 RELQELQEKYRVVEKQKPKVQLQERVSEIFQVLPETEQEIRRLRAQ--LQETGSKKSGVEQEVEKLLPELEVLRAQKPVV 1306
Cdd:COG1196    474 LLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLrgLAGAVAVLIGVEAAYEAALEAALAAALQNIVV 553

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1307 EYKEVTQEVVRHEKNpevlREIDRLKAQLNELVNTNGRSQEQLIRLQGERDEWKRERSKVETKMVSKEVVRH--EKDPVL 1384
Cdd:COG1196    554 EDDEVAAAAIEYLKA----AKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTllGRTLVA 629

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1385 EKEAERLRQEVREAVQRRRATEDAVYELQNKLLLLERRRpeeqivvqevvvtqkdpKLREEHSRLSRSLDEEVGRRRQLE 1464
Cdd:COG1196    630 ARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRR-----------------ELLAALLEAEAELEELAERLAEEE 692

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1465 LEVRQLGARVEEEEARLSFEEDRSKKLAAERELRQLTLKIQELEKRPPALQEKIIMEEVVKLEKDPDLERstEALRRELD 1544
Cdd:COG1196    693 LELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDL--EELERELE 770


                   ....*....
gi 1907079978 1545 QEKNRVTEL 1553
Cdd:COG1196    771 RLEREIEAL 779
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 798-1732 9.56e-16

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 83.96  E-value: 9.56e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  798 REKIVQDASLTYQQLRNSRDNLSSWLEQLPHHRVQPS--------DGPSQISYKLQAQKRLIQEILGreqdqatVSRLTR 869
Cdd:TIGR02169   98 RLKVTDDGKYSYYYLNGQRVRLSEIHDFLAAAGIYPEgynvvlqgDVTDFISMSPVERRKIIDEIAG-------VAEFDR 170

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  870 DLQEALQDYElqadTYRCSLEPALAVSAPKRLRVISLQEsiqaqEKNLAKAYTEVaaaeQQQLRQLEFAKKMLRKKELDE 949
Cdd:TIGR02169  171 KKEKALEELE----EVEENIERLDLIIDEKRQQLERLRR-----EREKAERYQAL----LKEKREYEGYELLKEKEALER 237

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  950 DIQAIHSARQGsgspahaRTAESEVLKTQLEEERKRVAEVQRDLEEQRQRLLQLRTQQPVARLEEKEVVEFYRDpQLESN 1029
Cdd:TIGR02169  238 QKEAIERQLAS-------LEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQLRVKEKIGELEAEIA-SLERS 309

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1030 LSQAASRVEEEGKRRARLQAELEAVAQKVVHLEGKRKTMQPHL--LTKEVTQI-ERDPGLDSQVTQLHSEMQRLRGENGV 1106
Cdd:TIGR02169  310 IAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRdkLTEEYAELkEELEDLRAELEEVDKEFAETRDELKD 389

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1107 LTARLEELKDEL--LALEQKEMNVKEKVVVKEVVKVEKDLEMVKAAQT--------LRLQIEEDAARRKGAKETVAKIQA 1176
Cdd:TIGR02169  390 YREKLEKLKREIneLKRELDRLQEELQRLSEELADLNAAIAGIEAKINeleeekedKALEIKKQEWKLEQLAADLSKYEQ 469

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1177 RIKDLEQAISSVEPKVIVKEVKKVEQDP--GLLKEASRLRSLLEEEKNNNV----ALARELQELQEKYR----------- 1239
Cdd:TIGR02169  470 ELYDLKEEYDRVEKELSKLQRELAEAEAqaRASEERVRGGRAVEEVLKASIqgvhGTVAQLGSVGERYAtaievaagnrl 549

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1240 ---VVEKQKPKVQ----LQERVSEIFQVLPeteqeIRRLRAQLQETG-SKKSGVeqeVEKLLPELEVLRAQKPVVEYKEV 1311
Cdd:TIGR02169  550 nnvVVEDDAVAKEaielLKRRKAGRATFLP-----LNKMRDERRDLSiLSEDGV---IGFAVDLVEFDPKYEPAFKYVFG 621

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1312 TQEVVRHEKNPEVLREIDRLKAQLNELVNTNGRSQEQLIRLQGERDEWKRERSKVETkmvskevVRHEKDPvLEKEAERL 1391
Cdd:TIGR02169  622 DTLVVEDIEAARRLMGKYRMVTLEGELFEKSGAMTGGSRAPRGGILFSRSEPAELQR-------LRERLEG-LKRELSSL 693

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1392 RQEVREAVQRRRATEDAVYELQNKLLLLERRRPEeqivvqevvvtqkdpkLREEHSRLsrsldeevgRRRQLELEVRQLG 1471
Cdd:TIGR02169  694 QSELRRIENRLDELSQELSDASRKIGEIEKEIEQ----------------LEQEEEKL---------KERLEELEEDLSS 748

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1472 ARVEEEEARLSFEEDRSKKLAAERELRQLTLKIQELEKRPPALQEKIIMEEVVKLEKDpdlERSTEALRRELDQEKNRVT 1551
Cdd:TIGR02169  749 LEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKLEEE---VSRIEARLREIEQKLNRLT 825

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1552 E----LHRECQGLQVQVDLLQ-KTKSQEKTIYKEVIRVEK-DPVLEGERARVWEIlnreRAARKGREEDVRSLQERIdra 1625
Cdd:TIGR02169  826 LekeyLEKEIQELQEQRIDLKeQIKSIEKEIENLNGKKEElEEELEELEAALRDL----ESRLGDLKKERDELEAQL--- 898

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1626 EALRRSWSREEAELQRARDQASQDCGRLQRQLRELEQQKQQKARQLQEEGRLLS-QKTESERQKAAQRSQAVTQLEAAIL 1704
Cdd:TIGR02169  899 RELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEELSlEDVQAELQRVEEEIRALEPVNMLAI 978

                          970       980
                   ....*....|....*....|....*...
gi 1907079978 1705 QEKDkiyEKERTLRDLHTKvsREELNQE 1732
Cdd:TIGR02169  979 QEYE---EVLKRLDELKEK--RAKLEEE 1001
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1384-1734 4.12e-15

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 81.52  E-value: 4.12e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1384 LEKEAERLRQEVREAVQRRRATEDAVyELQNKLLLLERRRpeeqivvqevvvtqkdpkLREEHSRLSRSLDEEVGRRRQL 1463
Cdd:COG1196    198 LERQLEPLERQAEKAERYRELKEELK-ELEAELLLLKLRE------------------LEAELEELEAELEELEAELEEL 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1464 ELEVRQLGArvEEEEARLSFEEDRSKKLAAERELRQLTLKIQELEKrppalqekiimeevvklEKDPDLERStEALRREL 1543
Cdd:COG1196    259 EAELAELEA--ELEELRLELEELELELEEAQAEEYELLAELARLEQ-----------------DIARLEERR-RELEERL 318

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1544 DQEKNRVTELHRECQGLQVQVDLLQKTKSQEKTIYKEvirvekdpvLEGERARVWEILNRERAARKGREEDVRSLQERID 1623
Cdd:COG1196    319 EELEEELAELEEELEELEEELEELEEELEEAEEELEE---------AEAELAEAEEALLEAEAELAEAEEELEELAEELL 389

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1624 RAEALRRSWSREEAELQRARDQASQDCGRLQRQLRELEQQKQQKARQLQEEGRLLSQKTESERQKAAQRSQAVTQLEAAI 1703
Cdd:COG1196    390 EALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELL 469

                          330       340       350
                   ....*....|....*....|....*....|.
gi 1907079978 1704 LQEKDKIYEKERTLRDLHTKVSREELNQETQ 1734
Cdd:COG1196    470 EEAALLEAALAELLEELAEAAARLLLLLEAE 500
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
979-1553 1.59e-13

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 76.23  E-value: 1.59e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  979 LEEERKRVAE----VQRDLEEQRQRLLQLRTQqpVARLEEKEVVEfyRDPQLESNLSQAASRVE--EEGKRRAR-----L 1047
Cdd:PRK02224   164 LEEYRERASDarlgVERVLSDQRGSLDQLKAQ--IEEKEEKDLHE--RLNGLESELAELDEEIEryEEQREQARetrdeA 239

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1048 QAELEAVAQKVVHLEGKRKTMQPHLLTKEVTQIERDpGLDSQVTQLHSEMQRLRGENGVLTAR--LEELKDELLALEQKE 1125
Cdd:PRK02224   240 DEVLEEHEERREELETLEAEIEDLRETIAETERERE-ELAEEVRDLRERLEELEEERDDLLAEagLDDADAEAVEARREE 318

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1126 MNVKEKVVVKEVVKVEKDLEMVKA---------------AQTLRLQIEEDAARRKGAKETVAKIQARIKDLEQAISSVEP 1190
Cdd:PRK02224   319 LEDRDEELRDRLEECRVAAQAHNEeaeslredaddleerAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRE 398

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1191 KVIVKevkkveqdPGLLKEASRLRSLLEEEKNNnvaLARELQELQEKYRVVEkqkpkvqlqERVSEIFQVL-----PETE 1265
Cdd:PRK02224   399 RFGDA--------PVDLGNAEDFLEELREERDE---LREREAELEATLRTAR---------ERVEEAEALLeagkcPECG 458

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1266 QEIRRlrAQLQETGSKKsgvEQEVEKLLPELEVLRAQKpvveyKEVTQEVVRHEKNPEVLREIDRLKAQ---LNELVNTn 1342
Cdd:PRK02224   459 QPVEG--SPHVETIEED---RERVEELEAELEDLEEEV-----EEVEERLERAEDLVEAEDRIERLEERredLEELIAE- 527

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1343 grsQEQLIRLQGERDEWKRER-SKVETKMVSKEVVRHEKdpvlEKEAERLRQEVREAVQRRRATEDAVYELQNKLLLLER 1421
Cdd:PRK02224   528 ---RRETIEEKRERAEELRERaAELEAEAEEKREAAAEA----EEEAEEAREEVAELNSKLAELKERIESLERIRTLLAA 600

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1422 RRPEEQIVVqevvvtqkdpKLREEHSRLSRSLDEEVGRRRQLELEVRQLGARVEEEearlSFEEDRSKKLAAERELRQLT 1501
Cdd:PRK02224   601 IADAEDEIE----------RLREKREALAELNDERRERLAEKRERKRELEAEFDEA----RIEEAREDKERAEEYLEQVE 666

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1907079978 1502 LKIQELEKRPPALQEKIIMEEvvklekdPDLERsTEALRRELDQEKNRVTEL 1553
Cdd:PRK02224   667 EKLDELREERDDLQAEIGAVE-------NELEE-LEELRERREALENRVEAL 710
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1206-1742 9.54e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 73.94  E-value: 9.54e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1206 LLKEASRLRSLLEEEKNNNVALARELQELQEKyrVVEKQKPKVQLQERVSEIFQVLPETEQEIRRLRAQLQETGSKKSGV 1285
Cdd:TIGR02168  237 LREELEELQEELKEAEEELEELTAELQELEEK--LEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANL 314

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1286 EQEVEKLLPELEVLRAQKPVVEYKEVTQEVVRHEKNPEVLR---EIDRLKAQLNELVNTNGRSQEQLIRLQGERDEWKRE 1362
Cdd:TIGR02168  315 ERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESleaELEELEAELEELESRLEELEEQLETLRSKVAQLELQ 394

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1363 RSKvetkmVSKEVVRHEKD-PVLEKEAERLRQEVREavQRRRATEDAVYELQNKLLLLERRRpeeqivvqevvvtqkdPK 1441
Cdd:TIGR02168  395 IAS-----LNNEIERLEARlERLEDRRERLQQEIEE--LLKKLEEAELKELQAELEELEEEL----------------EE 451

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1442 LREEHSRLSRSLDEEVGRRRQLELEVRQLGARVEEEEARL-SFEEDRSKKLAAERELRQLTLKIQELEKRPPALQEKIIM 1520
Cdd:TIGR02168  452 LQEELERLEEALEELREELEEAEQALDAAERELAQLQARLdSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISV 531

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1521 EEVVKLEKDPDLERSTEALRRELDQEKNRVTELHRE--------CQGLQVQVDLLQKTKSQEKTIYKEVIRVEKDPVLEG 1592
Cdd:TIGR02168  532 DEGYEAAIEAALGGRLQAVVVENLNAAKKAIAFLKQnelgrvtfLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFD 611

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1593 ERARVW-----------------------------------EILNRERAARKGREEDVRSLQER---IDRAEALRRSWSR 1634
Cdd:TIGR02168  612 PKLRKAlsyllggvlvvddldnalelakklrpgyrivtldgDLVRPGGVITGGSAKTNSSILERrreIEELEEKIEELEE 691

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1635 EEAELQRARDQASQDCGRLQRQLRELEQQKQQKARQL---QEEGRLLSQKTESERQKAAQRSQAVTQLEAAILQEKDKIY 1711
Cdd:TIGR02168  692 KIAELEKALAELRKELEELEEELEQLRKELEELSRQIsalRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLE 771

                          570       580       590
                   ....*....|....*....|....*....|.
gi 1907079978 1712 EKERTLRDLHTKvsREELNQETQTRETNLST 1742
Cdd:TIGR02168  772 EAEEELAEAEAE--IEELEAQIEQLKEELKA 800
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1217-1720 7.48e-12

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 70.86  E-value: 7.48e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1217 LEEEKNNNVALARELQELQEKYRVVEKQKPkvQLQERVSEIFQVLPETEQEIRRLRAQLQETGSKKSGVE---QEVEKLL 1293
Cdd:PRK03918   160 YENAYKNLGEVIKEIKRRIERLEKFIKRTE--NIEELIKEKEKELEEVLREINEISSELPELREELEKLEkevKELEELK 237

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1294 PELEVLRAQKPVVEYKEVTQEvvrhEKNPEVLREIDRLKAQLNELVNTNGRSQE------QLIRLQGERDEWKRERSKVE 1367
Cdd:PRK03918   238 EEIEELEKELESLEGSKRKLE----EKIRELEERIEELKKEIEELEEKVKELKElkekaeEYIKLSEFYEEYLDELREIE 313

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1368 TKMVSKEVVRHEKDPVLeKEAERLRQEVREAVQRRRATEDAVYELQNKLLLLERRRPeeqivVQEVVVTQKDPKLREEHS 1447
Cdd:PRK03918   314 KRLSRLEEEINGIEERI-KELEEKEERLEELKKKLKELEKRLEELEERHELYEEAKA-----KKEELERLKKRLTGLTPE 387

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1448 RLSRSLDEEVGRRRQLELEVRQLGARV-----EEEEARLSFEEDRSKK---------LAAERE---LRQLTLKIQELEKR 1510
Cdd:PRK03918   388 KLEKELEELEKAKEEIEEEISKITARIgelkkEIKELKKAIEELKKAKgkcpvcgreLTEEHRkelLEEYTAELKRIEKE 467

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1511 PPALQEKI--IMEEVVKLEKDPDLERSTEALRRELDQEKNRVTELHR-ECQGLQVQVDLLQKTKSQEKTIYKEVIRVEKD 1587
Cdd:PRK03918   468 LKEIEEKErkLRKELRELEKVLKKESELIKLKELAEQLKELEEKLKKyNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKE 547

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1588 ----PVLEGERARVWEIL--------NRERAARKGREEDVRSLQERIDRAEALRRSW----------SREEAELQRARDQ 1645
Cdd:PRK03918   548 leklEELKKKLAELEKKLdeleeelaELLKELEELGFESVEELEERLKELEPFYNEYlelkdaekelEREEKELKKLEEE 627

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907079978 1646 ASQDCGRLQRQLRELEQQKqqkaRQLQEEGRLLSQKT-ESERQKAAQRSQAVTQLEAAILQEKDKIYEKERTLRDL 1720
Cdd:PRK03918   628 LDKAFEELAETEKRLEELR----KELEELEKKYSEEEyEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKL 699
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 586-1367 8.15e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 70.86  E-value: 8.15e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  586 SQMTQLDGDLGQIERQVLSWARSPLSQSSSLKDLEGRIHSCEGTAQ----RLQSLGAEKEAAQQECEAFLSTKPTGSAAL 661
Cdd:TIGR02168  260 AELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQilreRLANLERQLEELEAQLEELESKLDELAEEL 339

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  662 -QLPVVLNSVKNRYNDVQSLchlYGEKAKAALGLEKQIQEADRVIQGFEAALA-LEGPVPEGSGALQERVSELQRQRKEL 739
Cdd:TIGR02168  340 aELEEKLEELKEELESLEAE---LEELEAELEELESRLEELEEQLETLRSKVAqLELQIASLNNEIERLEARLERLEDRR 416

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  740 LQQQACVLGLHRQLKatEHACSALQNNFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLREKIVQDASLTYQQLRNSRDNL 819
Cdd:TIGR02168  417 ERLQQEIEELLKKLE--EAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSL 494

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  820 SSWLEQLphhrvqpsDGPSQISYKLQAQKRLIQEILGREQDQATV-----------------SRLTRDLQEALQDYEL-- 880
Cdd:TIGR02168  495 ERLQENL--------EGFSEGVKALLKNQSGLSGILGVLSELISVdegyeaaieaalggrlqAVVVENLNAAKKAIAFlk 566

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  881 QADTYRCSLEPALAVSAPK----RLRVISLQESIQAQEKNLAKAYTEVAAAEQQQLRQ------LEFAKKMLRKKELDED 950
Cdd:TIGR02168  567 QNELGRVTFLPLDSIKGTEiqgnDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGvlvvddLDNALELAKKLRPGYR 646

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  951 I-----QAIHsaRQGSGSPAHARTAESEVLKTQ-LEEERKRVAEVQRDLEEQRQRLLQLRTQQPvarleekevvefyrdp 1024
Cdd:TIGR02168  647 IvtldgDLVR--PGGVITGGSAKTNSSILERRReIEELEEKIEELEEKIAELEKALAELRKELE---------------- 708

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1025 QLESNLSQAASRVEEEGKRRARLQAELEAVAQKVVHLEgkrktmqphlltkevtqierdpgldSQVTQLHSEMQRLRGEN 1104
Cdd:TIGR02168  709 ELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLE-------------------------ERIAQLSKELTELEAEI 763

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1105 GVLTARLEELKDELLALEQKEMNVKEKVVvkevvkvekdlEMVKAAQTLRLQIEEDAARRKGAKETVAKIQARIKDLEQA 1184
Cdd:TIGR02168  764 EELEERLEEAEEELAEAEAEIEELEAQIE-----------QLKEELKALREALDELRAELTLLNEEAANLRERLESLERR 832

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1185 ISSVEpkviVKEVKKVEQDPGLLKEASRLRSLLEEEKNNNVALARELQELQEKYRVVEKQKpkVQLQERVSEIFQVLPET 1264
Cdd:TIGR02168  833 IAATE----RRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEAL--ALLRSELEELSEELREL 906

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1265 EQEIRRLRAQLQETGSKKSGVEQEVEKLLPELEVLRAQKPV---VEYKEVTQEVVRHEKNPEVLR-EIDRLKAQLNELVN 1340
Cdd:TIGR02168  907 ESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEeysLTLEEAEALENKIEDDEEEARrRLKRLENKIKELGP 986

                          810       820
                   ....*....|....*....|....*..
gi 1907079978 1341 TNGRSQEQLIRLQGERDEWKRERSKVE 1367
Cdd:TIGR02168  987 VNLAAIEEYEELKERYDFLTAQKEDLT 1013
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 615-1397 1.40e-11

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 70.09  E-value: 1.40e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  615 SLKDLEGRIHSCEGTAQRLQSLGAEKEAAQQECEAFLStkptgsaalQLPVVLNSVKNRYNDVQslcHLYGEKAKAALGL 694
Cdd:TIGR02168  233 RLEELREELEELQEELKEAEEELEELTAELQELEEKLE---------ELRLEVSELEEEIEELQ---KELYALANEISRL 300

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  695 EKQIQEADRVIQGFEAALAlegpvpegsgALQERVSELQRQRKELLQQqacvlglhrqLKATEHACSALQNNFQEFCQDL 774
Cdd:TIGR02168  301 EQQKQILRERLANLERQLE----------ELEAQLEELESKLDELAEE----------LAELEEKLEELKEELESLEAEL 360

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  775 PRQQRQVRALTDRYHAVGDQLDLREKIVQDASLTYQQLRNSRDNLSSWLEQLPHHRVQPSDGPSQISYKLQ-AQKRLIQE 853
Cdd:TIGR02168  361 EELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEeAELKELQA 440

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  854 ILGREQDQATvsrltrDLQEALQDYELQADTYRCSLEPALAVSAPKRLRVISLQ---ESIQAQEKNLAKAYTEVAAAEQQ 930
Cdd:TIGR02168  441 ELEELEEELE------ELQEELERLEEALEELREELEEAEQALDAAERELAQLQarlDSLERLQENLEGFSEGVKALLKN 514

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  931 QLR----------QLEFAKKMLRKKE--LDEDIQAIHSARQGSGSPAHARTAESEVLK-TQLEEERKRVAEVQRDLEEQR 997
Cdd:TIGR02168  515 QSGlsgilgvlseLISVDEGYEAAIEaaLGGRLQAVVVENLNAAKKAIAFLKQNELGRvTFLPLDSIKGTEIQGNDREIL 594

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  998 QrllqlrtQQPVARLEEKEVVEFyrDPQLESNLSQ--AASRVEEEGKRRARLQAELEAvAQKVVHLEGkrktmqpHLLTK 1075
Cdd:TIGR02168  595 K-------NIEGFLGVAKDLVKF--DPKLRKALSYllGGVLVVDDLDNALELAKKLRP-GYRIVTLDG-------DLVRP 657

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1076 EVTQIERDPGLDSQVTQLHSEMQRLRGENGVLTARLEELKDELLALEQK--EMNVKEKVVVKEVVKVEKDL-EMVKAAQT 1152
Cdd:TIGR02168  658 GGVITGGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKEleELEEELEQLRKELEELSRQIsALRKDLAR 737

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1153 LRLQIEEDAARRKGAKETVAKIQARIKDLEQAISSVEPKVIVKEVKKVEQDP---GLLKEASRLRSLLEEEKNNNVALAR 1229
Cdd:TIGR02168  738 LEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAqieQLKEELKALREALDELRAELTLLNE 817

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1230 ELQELQEKYRVVEKQkpKVQLQERVSEIFQVLPETEQEIRRLRAQLQETGSKKSGVEQEVEKLLPELEVLRAQKPVVEYK 1309
Cdd:TIGR02168  818 EAANLRERLESLERR--IAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSE 895

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1310 EVTQEVVRHEKNpevlREIDRLKAQLNELVNTNGRSQEQLIRLQGERDEWK---RERSKVETKMVSKEVVRHEKDP-VLE 1385
Cdd:TIGR02168  896 LEELSEELRELE----SKRSELRRELEELREKLAQLELRLEGLEVRIDNLQerlSEEYSLTLEEAEALENKIEDDEeEAR 971

                          810
                   ....*....|..
gi 1907079978 1386 KEAERLRQEVRE 1397
Cdd:TIGR02168  972 RRLKRLENKIKE 983
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1213-1602 1.94e-11

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 69.70  E-value: 1.94e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1213 LRSLLEE------------EKNNNVALARE-LQELQEKYRVVEKQKPKVQLQERVSEIFQ----------------VLPE 1263
Cdd:TIGR02168  157 RRAIFEEaagiskykerrkETERKLERTREnLDRLEDILNELERQLKSLERQAEKAERYKelkaelrelelallvlRLEE 236

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1264 TEQEIRRLRAQLQETGSKKSGVEQEVEKLLPELEVLRAQKPVVEYKEVTQEvvrhEKNPEVLREIDRLKAQLNELVNTNG 1343
Cdd:TIGR02168  237 LREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQ----KELYALANEISRLEQQKQILRERLA 312

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1344 RSQEQLIRLQGERDEWKRERSKVETKMVSKEvvrhEKDPVLEKEAERLRQEVREAVQRRRATEDAVYELQNKllllerrr 1423
Cdd:TIGR02168  313 NLERQLEELEAQLEELESKLDELAEELAELE----EKLEELKEELESLEAELEELEAELEELESRLEELEEQ-------- 380

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1424 peeqivvqevvvtqkdpklreehsrlsrsLDEEVGRRRQLELEVRQLGARVEEEEARLSFEEDRSKKLAAERELRQLTLK 1503
Cdd:TIGR02168  381 -----------------------------LETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLE 431

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1504 IQELEKRPPALQEKIIMEEVVKlEKDPDLERSTEALRRELDQEKNRVTELHRECQGLQVQVDLLQKTKSQEKTIYKEVIR 1583
Cdd:TIGR02168  432 EAELKELQAELEELEEELEELQ-EELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKA 510

                          410       420
                   ....*....|....*....|
gi 1907079978 1584 VEKD-PVLEGERARVWEILN 1602
Cdd:TIGR02168  511 LLKNqSGLSGILGVLSELIS 530
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1075-1642 1.95e-11

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 69.71  E-value: 1.95e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1075 KEVTQIERdpgldsQVTQLHSEMQRLRGENGVLTARLEELKDELLALEQKEmnvkekvvvkevvkvEKDLEMVKAAQTLR 1154
Cdd:PRK03918   200 KELEEVLR------EINEISSELPELREELEKLEKEVKELEELKEEIEELE---------------KELESLEGSKRKLE 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1155 LQIEEDAARRKGAKETVAKIQARIKDLEQAISSVEPKVIVKEVKKVEQDP--GLLKEASRLRSLLEEeknnnvaLARELQ 1232
Cdd:PRK03918   259 EKIRELEERIEELKKEIEELEEKVKELKELKEKAEEYIKLSEFYEEYLDElrEIEKRLSRLEEEING-------IEERIK 331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1233 ELQEKYRVVEKQKPKVQLQERVSEIFQVLPETEQEIRRLRAQLQETGSKKSGveQEVEKLLPELEVLRAQKPVV--EYKE 1310
Cdd:PRK03918   332 ELEEKEERLEELKKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTG--LTPEKLEKELEELEKAKEEIeeEISK 409

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1311 VTQEVVRHEKnpevlrEIDRLKAQLNELVNTNGRSQEQLIRLQGERDEWKRERSKVETKMVSKEVVR-HEKDPVLEKEAE 1389
Cdd:PRK03918   410 ITARIGELKK------EIKELKKAIEELKKAKGKCPVCGRELTEEHRKELLEEYTAELKRIEKELKEiEEKERKLRKELR 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1390 RLRQEVREA--VQRRRATEDAVYELQNKLlllerrrpEEQIVVQEVVVTQKDPKLREEHSRLS---RSLDEEVGRRRQLE 1464
Cdd:PRK03918   484 ELEKVLKKEseLIKLKELAEQLKELEEKL--------KKYNLEELEKKAEEYEKLKEKLIKLKgeiKSLKKELEKLEELK 555

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1465 LEVRQLGARVEEEEARLSFEEDRSKKLAAErELRQLTLKIQELEKrppalqekiIMEEVVKLEKDP----DLERSTEALR 1540
Cdd:PRK03918   556 KKLAELEKKLDELEEELAELLKELEELGFE-SVEELEERLKELEP---------FYNEYLELKDAEkeleREEKELKKLE 625

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1541 RELDQEKNRVTELHRECQGLQVQVDLLQKTKSQEKTIYKEVIRVEKDPVLEGERARVWEI-------------LNRERAA 1607
Cdd:PRK03918   626 EELDKAFEELAETEKRLEELRKELEELEKKYSEEEYEELREEYLELSRELAGLRAELEELekrreeikktlekLKEELEE 705

                          570       580       590
                   ....*....|....*....|....*....|....*
gi 1907079978 1608 RKGREEDVRSLQERIDRAEALRRSWSREEAELQRA 1642
Cdd:PRK03918   706 REKAKKELEKLEKALERVEELREKVKKYKALLKER 740
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 976-1673 2.36e-11

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 69.43  E-value: 2.36e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  976 KTQLEEERKRVAEVQRDLEEQRQRLL-QLRTQQPV-ARLEEKEVVEFYRDPQLESNLSQAASRVEEEGKRRARLQAElea 1053
Cdd:pfam01576   21 QQKAESELKELEKKHQQLCEEKNALQeQLQAETELcAEAEEMRARLAARKQELEEILHELESRLEEEEERSQQLQNE--- 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1054 vaqkvvhlegkRKTMQPHLLTkevtqierdpgLDSQVTQLHSEMQRLRGENGVLTARLEELKDELLALE------QKEMN 1127
Cdd:pfam01576   98 -----------KKKMQQHIQD-----------LEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEdqnsklSKERK 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1128 VKEKVVVKEVVKVEKDLEMVKAAQTLRLQIEedaarrkgakETVAKIQARIKDLEQAISSVEPKVIVKEVKKVEqdpgLL 1207
Cdd:pfam01576  156 LLEERISEFTSNLAEEEEKAKSLSKLKNKHE----------AMISDLEERLKKEEKGRQELEKAKRKLEGESTD----LQ 221

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1208 KEASRLRSLLEEEKNNNVALARELQELQEkyRVVEKQKPKVQLQERVSEIFQVLPETEQEIRRLRAQLQETGSKKSGVEQ 1287
Cdd:pfam01576  222 EQIAELQAQIAELRAQLAKKEEELQAALA--RLEEETAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQRRDLGE 299

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1288 EVEKLLPELE----VLRAQKPVVEYKEvtQEVVRHEKNPEvlREIDRLKAQLNELvntNGRSQEQLIRLQGERDEWKRER 1363
Cdd:pfam01576  300 ELEALKTELEdtldTTAAQQELRSKRE--QEVTELKKALE--EETRSHEAQLQEM---RQKHTQALEELTEQLEQAKRNK 372

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1364 SKVETKMVSKEVVRHEkdpvLEKEAERLRQEVREAVQRRRATEDAVYELQNKLLLLERRRPEEQIVVQE----------- 1432
Cdd:pfam01576  373 ANLEKAKQALESENAE----LQAELRTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKlqselesvssl 448

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1433 -VVVTQKDPKLREEHSRLSRSL-------DEEVGRRRQLELEVRQLgarvEEEEARL--SFEEDRSKKLAAERELRQLTL 1502
Cdd:pfam01576  449 lNEAEGKNIKLSKDVSSLESQLqdtqellQEETRQKLNLSTRLRQL----EDERNSLqeQLEEEEEAKRNVERQLSTLQA 524

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1503 KIQELEKRppaLQEKIIMEEVVKlEKDPDLERSTEALRRELDQEKNRVTELHRECQGLQVQVDLLQKTKSQEKTIYKEVI 1582
Cdd:pfam01576  525 QLSDMKKK---LEEDAGTLEALE-EGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLE 600

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1583 RVEK--DPVLEGERARVWEILN-RERAARKGREEDVRSL---------QERIDRAEALRRSWSREEAELQRARDQASQDC 1650
Cdd:pfam01576  601 KKQKkfDQMLAEEKAISARYAEeRDRAEAEAREKETRALslaraleeaLEAKEELERTNKQLRAEMEDLVSSKDDVGKNV 680

                          730       740
                   ....*....|....*....|...
gi 1907079978 1651 GRLQRQLRELEQQKQQKARQLQE 1673
Cdd:pfam01576  681 HELERSKRALEQQVEEMKTQLEE 703
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1207-1727 1.56e-10

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 66.86  E-value: 1.56e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1207 LKEASRLRSLLEEEknnnVALARELQELQEKYRVVEKQKPKVQLQERVSEIfQVLpetEQEIRRLRAQLQETGSKKSGVE 1286
Cdd:COG4913    244 LEDAREQIELLEPI----RELAERYAAARERLAELEYLRAALRLWFAQRRL-ELL---EAELEELRAELARLEAELERLE 315

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1287 QEVEKLLPELEVLRAQKPVVEYKEVTQevvrheknpeVLREIDRLKAQLNELVNTNGRSQEQLIRLQ----GERDEWKRE 1362
Cdd:COG4913    316 ARLDALREELDELEAQIRGNGGDRLEQ----------LEREIERLERELEERERRRARLEALLAALGlplpASAEEFAAL 385

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1363 RSKVetkmvskevvrHEKDPVLEKEAERLRQEVREAVQRRRATEDAVYELQNKLLLLERRR---PEEQIVVQEV-----V 1434
Cdd:COG4913    386 RAEA-----------AALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKsniPARLLALRDAlaealG 454

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1435 VTQKDPK-------LREEHSR-----------LSRSL--DEEVGRRRQLELEVRQLGARVEEEEARLSFEEDRSKKLAAE 1494
Cdd:COG4913    455 LDEAELPfvgelieVRPEEERwrgaiervlggFALTLlvPPEHYAAALRWVNRLHLRGRLVYERVRTGLPDPERPRLDPD 534

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1495 RELRQLTLK-----------------------IQELEKRPPAL-QEKIIMEEVVKLEKDP------------DLERSTEA 1538
Cdd:COG4913    535 SLAGKLDFKphpfrawleaelgrrfdyvcvdsPEELRRHPRAItRAGQVKGNGTRHEKDDrrrirsryvlgfDNRAKLAA 614

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1539 LRRELDQEKNRVTELHRECQGLQVQVDLLQKTKSQEKTIyKEVIRVEKD-PVLEGERARvweiLNRERAARKGREEDVRS 1617
Cdd:COG4913    615 LEAELAELEEELAEAEERLEALEAELDALQERREALQRL-AEYSWDEIDvASAEREIAE----LEAELERLDASSDDLAA 689

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1618 LQERIDRAEAlrrswsrEEAELQRARDQASQDCGRLQRQLRELEQQKQQKARQLQEEGRLLSQKTES-------ERQKAA 1690
Cdd:COG4913    690 LEEQLEELEA-------ELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRAlleerfaAALGDA 762

                          570       580       590
                   ....*....|....*....|....*....|....*..
gi 1907079978 1691 QRSQAVTQLEAAILQEKDKIYEKERTLRDLHTKVSRE 1727
Cdd:COG4913    763 VERELRENLEERIDALRARLNRAEEELERAMRAFNRE 799
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1441-1737 3.56e-10

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 65.34  E-value: 3.56e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1441 KLREEHSRLSRSLD--EEVgrRRQLE-LEvRQlgARVEEEEARLSFEEDRSKKLAAERELRQLTLKIQELEKRppaLQEk 1517
Cdd:COG1196    180 KLEATEENLERLEDilGEL--ERQLEpLE-RQ--AEKAERYRELKEELKELEAELLLLKLRELEAELEELEAE---LEE- 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1518 iimeevvklekdpdLERSTEALRRELDQEKNRVTELHRECQGLQVQVDLLQKTKSQEKtiyKEVIRVEKDpvlegerarv 1597
Cdd:COG1196    251 --------------LEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELL---AELARLEQD---------- 303

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1598 weiLNRERAARKGREEDVRSLQERIDRAEALRRSWSREEAELQRARDQASQDCGRLQRQLRELEQQKQQKARQLQEEGRL 1677
Cdd:COG1196    304 ---IARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEE 380

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1678 LSQKTESERQKAAQRSQAVTQLEAAILQEKDKIYEKERTLRDLHTKVSREELNQETQTRE 1737
Cdd:COG1196    381 LEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEE 440
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 1916-1954 5.61e-10

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 56.18  E-value: 5.61e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1907079978 1916 LLEAQAATGGIVDLLSRERYSVHKAVERGLIENTSTQRL 1954
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1384-1762 7.91e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 64.31  E-value: 7.91e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1384 LEKEAERLRQEVREAvQRRRATEDAVYELQNKLLLLERRRpeeqivvqevvvtqkdpkLREEHSRLSRSLDEEVGRRRQL 1463
Cdd:TIGR02168  198 LERQLKSLERQAEKA-ERYKELKAELRELELALLVLRLEE------------------LREELEELQEELKEAEEELEEL 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1464 ELEVRQLGARVEEeeARLSFEEDRSKKLAAERELRQLTLKIQELEKRppalqekiIMEEVVKLEkdpDLERSTEALRREL 1543
Cdd:TIGR02168  259 TAELQELEEKLEE--LRLEVSELEEEIEELQKELYALANEISRLEQQ--------KQILRERLA---NLERQLEELEAQL 325

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1544 DQEKNRVTELHRECQGLQVQVDLLQKtksqektiykevirvekdpVLEGERARvweiLNRERAARKGREEDVRSLQERID 1623
Cdd:TIGR02168  326 EELESKLDELAEELAELEEKLEELKE-------------------ELESLEAE----LEELEAELEELESRLEELEEQLE 382

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1624 RAealrrswSREEAELQRARDQASqdcGRLQRQLRELEQQKQQKARQLQEEGRLLSQKTESERQKAAQRSQAVTQLEAAI 1703
Cdd:TIGR02168  383 TL-------RSKVAQLELQIASLN---NEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEEL 452

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907079978 1704 LQEKDKIYEKERTLRDLHTKVSREElnQETQTRETNLSTKICILEPETGNDMSPYEAYK 1762
Cdd:TIGR02168  453 QEELERLEEALEELREELEEAEQAL--DAAERELAQLQARLDSLERLQENLEGFSEGVK 509
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1206-1510 1.18e-09

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 63.60  E-value: 1.18e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1206 LLKEASRLRSLLEEEKNNNVALARELQELQEKYRVV---EKQKPKVQLQERVSEIFQV-LPETEQEIRRLRA--QLQ-ET 1278
Cdd:pfam17380  308 KAREVERRRKLEEAEKARQAEMDRQAAIYAEQERMAmerERELERIRQEERKRELERIrQEEIAMEISRMREleRLQmER 387

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1279 GSKKSGVEQEVE-----KLLPELEVLRAQKPVVEYKEV--TQEVVRHEK----NPEVLREIDRLKAQLNElvntngrSQE 1347
Cdd:pfam17380  388 QQKNERVRQELEaarkvKILEEERQRKIQQQKVEMEQIraEQEEARQREvrrlEEERAREMERVRLEEQE-------RQQ 460

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1348 QLIRLQGERDEWKRERSKVETKMVSKEVVRHEKDPVLEKEAERLRQEVREAVQRRRATEDAVYELQNKLLLLERRRpeeq 1427
Cdd:pfam17380  461 QVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEERKRKLLEKEMEERQKAIYEEERRR---- 536

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1428 ivvqevvvtqkdpKLREEhsrlsrsldeevgRRRQLELEVRQlgaRVEEEEARLSfeEDRSKKLAAERElRQLTLKIQEL 1507
Cdd:pfam17380  537 -------------EAEEE-------------RRKQQEMEERR---RIQEQMRKAT--EERSRLEAMERE-REMMRQIVES 584


                   ...
gi 1907079978 1508 EKR 1510
Cdd:pfam17380  585 EKA 587
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 1107-1673 1.32e-09

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 63.22  E-value: 1.32e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1107 LTARLEELKDELlalEQKEMNVKEKVvvkevvkvekdLEMVKAAQTLRLQIEEDAARRKgaketvaKIQARIKDLEQAIS 1186
Cdd:pfam05557    7 SKARLSQLQNEK---KQMELEHKRAR-----------IELEKKASALKRQLDRESDRNQ-------ELQKRIRLLEKREA 65

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1187 SVEPKVIVKEVKKveqdpGLLKEASRLRSLLEEEKNNNVALARELQ-----ELQEKYRVVEKQKPKVQLQ----ERVSEI 1257
Cdd:pfam05557   66 EAEEALREQAELN-----RLKKKYLEALNKKLNEKESQLADAREVIsclknELSELRRQIQRAELELQSTnselEELQER 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1258 FQVLPETEQEIRRLRAQLQETGSKKSGVEQEVEKLLPELEVLRAQKPVVeyKEVTQEVVRHeknPEVLREIDRLK---AQ 1334
Cdd:pfam05557  141 LDLLKAKASEAEQLRQNLEKQQSSLAEAEQRIKELEFEIQSQEQDSEIV--KNSKSELARI---PELEKELERLRehnKH 215

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1335 LNELVNTNGRSQEQ-------LIRLQGERDE---WKRERSKVETKMvsKEVVRHEKDPVLE-KEAERLRQEVREAVQRRR 1403
Cdd:pfam05557  216 LNENIENKLLLKEEvedlkrkLEREEKYREEaatLELEKEKLEQEL--QSWVKLAQDTGLNlRSPEDLSRRIEQLQQREI 293

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1404 ATEDAVYELQNKLLLLERRRPEEQIVVQEVVVTQKDPKL-REEHSRLSRSLDEEVgrrRQLELEVRQLGARVEEEEARLS 1482
Cdd:pfam05557  294 VLKEENSSLTSSARQLEKARRELEQELAQYLKKIEDLNKkLKRHKALVRRLQRRV---LLLTKERDGYRAILESYDKELT 370

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1483 FEEDRSKKLAAERELRQLTLKIQELEKRPPALQEKIIMEEVVKLEKDPDLERSTEALRRELDQE-----KNRVTELHREC 1557
Cdd:pfam05557  371 MSNYSPQLLERIEEAEDMTQKMQAHNEEMEAQLSVAEEELGGYKQQAQTLERELQALRQQESLAdpsysKEEVDSLRRKL 450

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1558 QGLQVQVDLLQKTK-SQEKTIYKEVIRVEKDPVlegeRARVWEI-LNRERAARKGREEDVRSLQERIDRAEALRRSWSRE 1635
Cdd:pfam05557  451 ETLELERQRLREQKnELEMELERRCLQGDYDPK----KTKVLHLsMNPAAEAYQQRKNQLEKLQAEIERLKRLLKKLEDD 526

                          570       580       590
                   ....*....|....*....|....*....|....*...
gi 1907079978 1636 EAELQRARDQASQDCGRLQRQLRELEQQKQQKARQLQE 1673
Cdd:pfam05557  527 LEQVLRLPETTSTMNFKEVLDLRKELESAELKNQRLKE 564
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 843-1689 1.93e-09

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 63.07  E-value: 1.93e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  843 KLQAQKRLIQEilgrEQDQATVSRLTRDLQEALQDYELQA-DTYRCSLEPALAVSAPKRLRVISLQESIQAQEKNLAKAY 921
Cdd:pfam02463  171 KKEALKKLIEE----TENLAELIIDLEELKLQELKLKEQAkKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELL 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  922 TEVAA--AEQQQLRQLEFAKKMLRKKELDEDIQAIHSarQGSGSPAHARTAESEVLKTQLEEERKRVAEVQRDLEEQRQR 999
Cdd:pfam02463  247 RDEQEeiESSKQEIEKEEEKLAQVLKENKEEEKEKKL--QEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKK 324

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1000 LLQLRTQQPVARLEEKEVVEFYRDPQLESNLSQaasrvEEEGKRRARLQAELEAVAQKVVHLEGKRKTMQPHLLTKEVTQ 1079
Cdd:pfam02463  325 KAEKELKKEKEEIEELEKELKELEIKREAEEEE-----EEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELEL 399

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1080 IERDPGLDSQVTQLHS--EMQRLRGENGVLTARLEELKDELLALEQKEMNVKEKVVVKEVVKVEKDLEMVKAAQTLRLQI 1157
Cdd:pfam02463  400 KSEEEKEAQLLLELARqlEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQL 479

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1158 EEDAARRKGAKETVAKIQARIKDleqaiSSVEPKVIVKEVKKVEQDPGLLKEASRLRSLLEEEKNNnVALARELQELQEK 1237
Cdd:pfam02463  480 VKLQEQLELLLSRQKLEERSQKE-----SKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVEN-YKVAISTAVIVEV 553

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1238 YRVVEKQKPKVQLQERVSEIFQVLPETEQEIRRLRAQLQeTGSKKSGVEQEVEKLLPELEVLRAQKPVVE--------YK 1309
Cdd:pfam02463  554 SATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLK-SIAVLEIDPILNLAQLDKATLEADEDDKRAkvvegilkDT 632

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1310 EVTQEVVRHEKNPEVLREIDRLKAQLNELVNTNGRSQEQLIRLQGERDEWKRERSKVETKMVSKEVVRHEKDPVLEKEAE 1389
Cdd:pfam02463  633 ELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEEL 712

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1390 -RLRQEVREAVQRRRATEDAVYELQNKLLLLERRRPEEQIVVQEVVVTQKDPKLREEHSRLSRSLDEEVGRRRQL-ELEV 1467
Cdd:pfam02463  713 kKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKvEEEK 792

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1468 RQLGARVEEEEARLSFEEDRSKKLAAERELRQL-TLKIQELEKRPPALQEKIIMEEVVKLEKDP----------DLERST 1536
Cdd:pfam02463  793 EEKLKAQEEELRALEEELKEEAELLEEEQLLIEqEEKIKEEELEELALELKEEQKLEKLAEEELerleeeitkeELLQEL 872

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1537 EALRRELDQEKNRVTELHRECQGLQVQVDLLQKTKS----QEKTIYKEVIRVEKDPVLEGERARVWEILNRERAARKGRE 1612
Cdd:pfam02463  873 LLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKlnllEEKENEIEERIKEEAEILLKYEEEPEELLLEEADEKEKEE 952

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907079978 1613 EDVRSLQERIDRAEALRRSWSREEAElqrARDQASQDCGRLQRQLRELEQQKQQKARQLQEEGRLLSQKTESERQKA 1689
Cdd:pfam02463  953 NNKEEEEERNKRLLLAKEELGKVNLM---AIEEFEEKEERYNKDELEKERLEEEKKKLIRAIIEETCQRLKEFLELF 1026
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 723-1509 4.72e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 62.01  E-value: 4.72e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  723 GALQERVSELQRQRKELLQQQAcvlGLHRQLKATEHACSALQNNFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLREKIV 802
Cdd:TIGR02169  297 GELEAEIASLERSIAEKERELE---DAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAEL 373

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  803 QDASLTYQQLRNSRDNLSSWLEQLPHHRvqpSDGPSQISYKLQAQKRLIQEILGREQDQATVSRLTRDLQEALQDYELQA 882
Cdd:TIGR02169  374 EEVDKEFAETRDELKDYREKLEKLKREI---NELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEI 450

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  883 DTYRCSLEPALAVSAPKRLRVISLQESIQAQEKNLAKAYTEVAAAE--QQQLRQLEFAKKMLRKkELDEDIQAIHS--AR 958
Cdd:TIGR02169  451 KKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEaqARASEERVRGGRAVEE-VLKASIQGVHGtvAQ 529

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  959 QGSGSPAHARTAESE--------VLKTqlEEERKRVAEVQRDLEEQRQRLLQLRTQQPVARLEEK-----------EVVE 1019
Cdd:TIGR02169  530 LGSVGERYATAIEVAagnrlnnvVVED--DAVAKEAIELLKRRKAGRATFLPLNKMRDERRDLSIlsedgvigfavDLVE 607

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1020 FyrDPQLESNLSQAASR---VE--EEGKR---RARLqaeleavaqkvVHLEGKrktmqphLLTKE--VTQIERDP-GLDS 1088
Cdd:TIGR02169  608 F--DPKYEPAFKYVFGDtlvVEdiEAARRlmgKYRM-----------VTLEGE-------LFEKSgaMTGGSRAPrGGIL 667

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1089 QVTQLHSEMQRLRgengvltARLEELKDELLALeQKEMNVKEKVVVKEVVKVEKDLEMVKAAQTLRLQIEEDAARrkgAK 1168
Cdd:TIGR02169  668 FSRSEPAELQRLR-------ERLEGLKRELSSL-QSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEK---LK 736

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1169 ETVAKIQARIKDLEQAISSVEpkvivkevkkveqdpgllKEASRLRSLLEEEKNNNVALARELQELQEKYRvvekqkpkv 1248
Cdd:TIGR02169  737 ERLEELEEDLSSLEQEIENVK------------------SELKELEARIEELEEDLHKLEEALNDLEARLS--------- 789

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1249 qlQERVSEIFQVLPETEQEIRRLRAQLQEtgskksgVEQEVEKLLPELEVLRAQKpvvEYKEVTQEVVRHEKNpEVLREI 1328
Cdd:TIGR02169  790 --HSRIPEIQAELSKLEEEVSRIEARLRE-------IEQKLNRLTLEKEYLEKEI---QELQEQRIDLKEQIK-SIEKEI 856

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1329 DRLKAQLNELVNTNGRSQEQLIRLQGERDEWKRERSKVETKMvskevvrhekdpvleKEAERLRQEVREAVQRRRateDA 1408
Cdd:TIGR02169  857 ENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQL---------------RELERKIEELEAQIEKKR---KR 918

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1409 VYELQNKLLLLERRrpeeqivvqeVVVTQKDPKLREEHSRLSRSLDEEVGRRRQLELEVRQLGA-------RVEEEEARL 1481
Cdd:TIGR02169  919 LSELKAKLEALEEE----------LSEIEDPKGEDEEIPEEELSLEDVQAELQRVEEEIRALEPvnmlaiqEYEEVLKRL 988

                          810       820
                   ....*....|....*....|....*...
gi 1907079978 1482 SFEEDRSKKLAAERElrQLTLKIQELEK 1509
Cdd:TIGR02169  989 DELKEKRAKLEEERK--AILERIEEYEK 1014
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
935-1423 4.74e-09

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 61.71  E-value: 4.74e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  935 LEFAKKMLRKKeLDEDIQAIHSARQGSGSPAHARTAESEVLKTQLEEERKRVAEVQRDLEEQRQRLLQLRTQQPVARLEE 1014
Cdd:COG4717     40 LAFIRAMLLER-LEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREEL 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1015 KEVVEFYRDPQLESNLSQAASRVEEEGKRRARLQAELEAVAQKVVHLEGKRKTMQPHLLTKEVTQIERDPGLDSQVTQLH 1094
Cdd:COG4717    119 EKLEKLLQLLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLA 198

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1095 SEMQRLRGENGVLTARLEELKDELLALEQKEMNVKEKVVVKEVVKVEKDLEMVKAAQTLRLQIEEDAARRKGAKETVAKI 1174
Cdd:COG4717    199 EELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAALLALLGLGGSLLSLILTIAGV 278

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1175 QA------------RIKDLEQAISSVEPKVIVKEVKKVEQDpGLLKEASRLRSLLEEEKNNNVALARELQELQEKYRVVE 1242
Cdd:COG4717    279 LFlvlgllallfllLAREKASLGKEAEELQALPALEELEEE-ELEELLAALGLPPDLSPEELLELLDRIEELQELLREAE 357

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1243 KQKPKVQLQERVSEIFQVLP----ETEQEIRRLRAQLqetgskksgveQEVEKLLPELEVLRAQkpVVEYKEVTQEVVRH 1318
Cdd:COG4717    358 ELEEELQLEELEQEIAALLAeagvEDEEELRAALEQA-----------EEYQELKEELEELEEQ--LEELLGELEELLEA 424

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1319 EKNPEVLREIDRLKAQLNELVNTNGRSQEQLIRLQGERDEWKRERSKVEtkmvskevvrhekdpvLEKEAERLRQEVREA 1398
Cdd:COG4717    425 LDEEELEEELEELEEELEELEEELEELREELAELEAELEQLEEDGELAE----------------LLQELEELKAELREL 488

                          490       500
                   ....*....|....*....|....*
gi 1907079978 1399 VQRRRATEDAVYELQNKLLLLERRR 1423
Cdd:COG4717    489 AEEWAALKLALELLEEAREEYREER 513
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1488-1703 5.83e-09

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 60.55  E-value: 5.83e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1488 SKKLAAERELRQLTLKIQELEKRppalQEKIIMEEVVKLEKDPDLERSTEALRRELDQEKNRVTELHRECQGLQVQVDLL 1567
Cdd:COG4942     20 DAAAEAEAELEQLQQEIAELEKE----LAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAEL 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1568 QKTKSQEKTIYKEVIRVEkdpVLEGERARVWEILNRERAARKGR-----EEDVRSLQERIDRAEALRRSWSREEAELQRA 1642
Cdd:COG4942     96 RAELEAQKEELAELLRAL---YRLGRQPPLALLLSPEDFLDAVRrlqylKYLAPARREQAEELRADLAELAALRAELEAE 172

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907079978 1643 RDQASQDCGRLQRQLRELEQQKQQKARQLQEegrlLSQKTESERQKAAQRSQAVTQLEAAI 1703
Cdd:COG4942    173 RAELEALLAELEEERAALEALKAERQKLLAR----LEKELAELAAELAELQQEAEELEALI 229
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 872-1552 8.86e-09

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 60.89  E-value: 8.86e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  872 QEALQDYELQADTYRCSLEPALAVSAPKRLRVISLQESIQAQEKNLAKAYTEVAAAEQQQLRQLEFAKKMLRKKeLDEDI 951
Cdd:pfam05483   62 QEGLKDSDFENSEGLSRLYSKLYKEAEKIKKWKVSIEAELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLK-LEEEI 140

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  952 QAIHSARQGSGSPAH---------ARTAESevlKTQLEEERKRVAEVQRDLEEQRQRLL----QLRTQQPVARLEekevV 1018
Cdd:pfam05483  141 QENKDLIKENNATRHlcnllketcARSAEK---TKKYEYEREETRQVYMDLNNNIEKMIlafeELRVQAENARLE----M 213

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1019 EFyrdpQLESNLSQAASRVEEEGKRRARLQAELEAVAQKVVHLEGKRKTMQPHLLTK--EVTQIErdpgldsQVTQLHSE 1096
Cdd:pfam05483  214 HF----KLKEDHEKIQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESrdKANQLE-------EKTKLQDE 282

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1097 -MQRLRGENGVLTARLEELKDELlaleQKEMNVKEKVVVKEVVKVEKDLEMVKAAQTlrlQIEEDAARRKGAKETVAKIQ 1175
Cdd:pfam05483  283 nLKELIEKKDHLTKELEDIKMSL----QRSMSTQKALEEDLQIATKTICQLTEEKEA---QMEELNKAKAAHSFVVTEFE 355

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1176 ARIKDLEQAISSVEPKVIVKEVKKVEQDPGLLKEASRLRSLLEEEKNNNVALARELQELQEKYRVVEKQKPKVQLQERV- 1254
Cdd:pfam05483  356 ATTCSLEELLRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKFKNNKEVELEELKKILAEDEKLLDEKKQFEKIAEELk 435

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1255 ---SEIFQVLPETEQEIRRLRAQLQETGSKKSGVEQEVEKLLPELE---------VLRAQKPVVEYKEVTQE-------- 1314
Cdd:pfam05483  436 gkeQELIFLLQAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEkeklknielTAHCDKLLLENKELTQEasdmtlel 515

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1315 ------VVRHEKNPE-VLREIDRLKAQLNELVNTNGRSQEQLIRlQGERDEWKRERSKVETKMVSKEVVRHEKD-PVLEK 1386
Cdd:pfam05483  516 kkhqedIINCKKQEErMLKQIENLEEKEMNLRDELESVREEFIQ-KGDEVKCKLDKSEENARSIEYEVLKKEKQmKILEN 594

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1387 EAERLRQEVR-------------EAVQRRRATEDA---VYELQ-NKL-LLLERRRPEEQIVVQEVVVTQKDPKLREEH-- 1446
Cdd:pfam05483  595 KCNNLKKQIEnknknieelhqenKALKKKGSAENKqlnAYEIKvNKLeLELASAKQKFEEIIDNYQKEIEDKKISEEKll 674

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1447 ---SRLSRSLDEEVGRRRQLELEVRQlgaRVEEEEARLSFEEDRSKKLAAER--ELRQLTLKIQELEKRPPALQEKI--I 1519
Cdd:pfam05483  675 eevEKAKAIADEAVKLQKEIDKRCQH---KIAEMVALMEKHKHQYDKIIEERdsELGLYKNKEQEQSSAKAALEIELsnI 751

                          730       740       750
                   ....*....|....*....|....*....|....
gi 1907079978 1520 MEEVVKLEKDPDLER-STEALRRELDQEKNRVTE 1552
Cdd:pfam05483  752 KAELLSLKKQLEIEKeEKEKLKMEAKENTAILKD 785
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 694-1271 9.89e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 60.72  E-value: 9.89e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  694 LEKQIQEADRVIQGFEAALALEgpvpegSGALQERVSELQRQRKELLQQQACVLGLHRQLKATEHACSALQNNFQEFCQD 773
Cdd:COG1196    244 LEAELEELEAELEELEAELAEL------EAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEER 317

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  774 LPRQQRQVRALTDRYHAVGDQLDLREKIVQDASLTYQQLRNSRDnlsswleqlphhrvqpsdgpsqisyklQAQKRLIQE 853
Cdd:COG1196    318 LEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELA---------------------------EAEEALLEA 370

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  854 ILGREQDQATVSRLTRDLQEALQDyELQADTYRCSLEPALAVSAPKRLRVISLQESIQAQEKNLAKAYTEVAAAEQQQLR 933
Cdd:COG1196    371 EAELAEAEEELEELAEELLEALRA-AAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAE 449

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  934 -QLEFAKKMLRKKELDEDIQAIHSARQGSGSPAHARTAESEVLKTQLEEERKRVAEVQRDLEEQRQRLLQLRTQQPVARL 1012
Cdd:COG1196    450 eEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVL 529

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1013 EEKEVVEFYRDPQLESNLSQAasRVEEEGKRRARLQAELEAVAQKVVHLEGKRKTMQPHLLTKEVTQIERDPGLDSQVTQ 1092
Cdd:COG1196    530 IGVEAAYEAALEAALAAALQN--IVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASD 607

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1093 LHSEMQRLRGENGVLTARLEELKDELLALEQKEMNVKEKVVVKEVVKVEKDLEMVKAAQTLRLQIEEDAARRKGAKETVA 1172
Cdd:COG1196    608 LREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAER 687

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1173 KIQARIKDLEQAISSVEpkVIVKEVKKVEQDPGLLKEASRLRSLLEEEKNNNVALARELQELQEKYRVVEKQKPKV--QL 1250
Cdd:COG1196    688 LAEEELELEEALLAEEE--EERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDleEL 765

                          570       580
                   ....*....|....*....|.
gi 1907079978 1251 QERVSEIfqvlpetEQEIRRL 1271
Cdd:COG1196    766 ERELERL-------EREIEAL 779
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1487-1737 2.42e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 59.57  E-value: 2.42e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1487 RSKKLAAERELRQ-------LTLKIQELEKRppalqekiimeeVVKLEKDPDLERSTEALRRELDQEKNRVTELHREcqG 1559
Cdd:COG1196    171 KERKEEAERKLEAteenlerLEDILGELERQ------------LEPLERQAEKAERYRELKEELKELEAELLLLKLR--E 236

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1560 LQVQVDLLQKTKSQEKTIyKEVIRVEKDpVLEGERARVWEILNRERAARKGREEDVRSLQERIDRAEALRRSWSREEAEL 1639
Cdd:COG1196    237 LEAELEELEAELEELEAE-LEELEAELA-ELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRREL 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1640 QRARDQASQDCGRLQRQLRELEQQKQQKARQLQEEGRLLSQKTESERQKAAQRSQAVTQLEAAILQEKDKIYEKERTLRD 1719
Cdd:COG1196    315 EERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRA 394

                          250
                   ....*....|....*...
gi 1907079978 1720 LHTKVSREELNQETQTRE 1737
Cdd:COG1196    395 AAELAAQLEELEEAEEAL 412
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1441-1744 2.51e-08

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 59.37  E-value: 2.51e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1441 KLREEHSRLSRsldeEVGRRRQLELEVRQLGARVEEEEARLSFEEdrskKLAAERElRQLTLKIQELEKRPpalQEKIIM 1520
Cdd:pfam17380  300 RLRQEKEEKAR----EVERRRKLEEAEKARQAEMDRQAAIYAEQE----RMAMERE-RELERIRQEERKRE---LERIRQ 367

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1521 EEV-VKLEKDPDLER-------STEALRRELDQ-EKNRVTELHRECQGLQVQVDLLQKTKSQEKTIYKEVIRvekdpvLE 1591
Cdd:pfam17380  368 EEIaMEISRMRELERlqmerqqKNERVRQELEAaRKVKILEEERQRKIQQQKVEMEQIRAEQEEARQREVRR------LE 441

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1592 GERARVWEILNRERAARKGREEDVRSLQERIDRAealRRSWSREEAELQRARDQasqdcgrlQRQLRELEQQKQQKARQL 1671
Cdd:pfam17380  442 EERAREMERVRLEEQERQQQVERLRQQEEERKRK---KLELEKEKRDRKRAEEQ--------RRKILEKELEERKQAMIE 510

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907079978 1672 QEEGRLLSQKTESERQKAAQRSQavTQLEAAILQEKDKIYEKERTLRDLHTKVSREELNQETQTRETNLSTKI 1744
Cdd:pfam17380  511 EERKRKLLEKEMEERQKAIYEEE--RRREAEEERRKQQEMEERRRIQEQMRKATEERSRLEAMEREREMMRQI 581
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1442-1712 2.74e-08

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 59.54  E-value: 2.74e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1442 LREEHSRLSRSLDEEVGRRRQLELEVRQLGARVEEEEARLSFEEDRSKKLAAERELRQLTLKIQELEKRPPALQEkiime 1521
Cdd:COG4913    615 LEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVASAEREIAELEAELERLDASSDDLAA----- 689

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1522 evvklekdpdLERSTEALRRELDQEKNRVTELHRECQGLQVQVDLLQKTKSQEKTIYKEVIRVEKDPVLEGERARVWEIL 1601
Cdd:COG4913    690 ----------LEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEERFAAAL 759

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1602 NRERAARKgreedVRSLQERIDRAEALRRswsREEAELQRARDQASQD----CGRLQRQLRELEQQkQQKARQLQEEGrL 1677
Cdd:COG4913    760 GDAVEREL-----RENLEERIDALRARLN---RAEEELERAMRAFNREwpaeTADLDADLESLPEY-LALLDRLEEDG-L 829

                          250       260       270
                   ....*....|....*....|....*....|....*
gi 1907079978 1678 LSQKTESERQKAAQRSQAVTQLEAAILQEKDKIYE 1712
Cdd:COG4913    830 PEYEERFKELLNENSIEFVADLLSKLRRAIREIKE 864
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
970-1585 3.15e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 58.92  E-value: 3.15e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  970 AESEVLKTQLEEERKRVAEVQRDLEEQRQRLlqlrtqqpvarleekevvefyrdPQLESNLSQAASRVEEEGKRRarlqA 1049
Cdd:PRK03918   186 KRTENIEELIKEKEKELEEVLREINEISSEL-----------------------PELREELEKLEKEVKELEELK----E 238

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1050 ELEAVAQKVVHLEGKRKTMQphlltkevtqierdpgldsqvtqlhsemQRLRGengvLTARLEELKDELLALEQKEmnvk 1129
Cdd:PRK03918   239 EIEELEKELESLEGSKRKLE----------------------------EKIRE----LEERIEELKKEIEELEEKV---- 282

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1130 ekvvvkevvkveKDLEMVKAAQTLRLQIEEdaaRRKGAKETVAKIQARIKDLEQAISSVEPkvivkevkkveqdpgLLKE 1209
Cdd:PRK03918   283 ------------KELKELKEKAEEYIKLSE---FYEEYLDELREIEKRLSRLEEEINGIEE---------------RIKE 332

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1210 ASRLRSLLEEEKNNNVALARELQELQEKYRVVEKQKPKVQLQERVS---------EIFQVLPETEQEIRRLRAQLQETGS 1280
Cdd:PRK03918   333 LEEKEERLEELKKKLKELEKRLEELEERHELYEEAKAKKEELERLKkrltgltpeKLEKELEELEKAKEEIEEEISKITA 412

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1281 KKSGVEQEVEKLLPELEVLRAQKPV--VEYKEVTQEvvrHEKN--PEVLREIDRLKAQLNELVNTNGRSQEQLIRLQGER 1356
Cdd:PRK03918   413 RIGELKKEIKELKKAIEELKKAKGKcpVCGRELTEE---HRKEllEEYTAELKRIEKELKEIEEKERKLRKELRELEKVL 489

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1357 DEWKRERSKVETKMVSKEVVRHEKDPVLEK------EAERLRQEVREAVQRRRATEDAV---YELQNKLLLLERRrpeeq 1427
Cdd:PRK03918   490 KKESELIKLKELAEQLKELEEKLKKYNLEElekkaeEYEKLKEKLIKLKGEIKSLKKELeklEELKKKLAELEKK----- 564

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1428 ivvqevvVTQKDPKLREEHSRLSR----SLDEEVGRRRQLE------LEVRQLGARVEEEEARLSFEEDRSKKlaAEREL 1497
Cdd:PRK03918   565 -------LDELEEELAELLKELEElgfeSVEELEERLKELEpfyneyLELKDAEKELEREEKELKKLEEELDK--AFEEL 635

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1498 RQLTLKIQELEKRPPALQEKIIMEEVVKL-EKDPDLERSTEALRRELDQEKNRVTELHRECQGLQVQVDLLQKTKSQEKT 1576
Cdd:PRK03918   636 AETEKRLEELRKELEELEKKYSEEEYEELrEEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKAKKELEK 715


                   ....*....
gi 1907079978 1577 IYKEVIRVE 1585
Cdd:PRK03918   716 LEKALERVE 724
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1328-1741 7.69e-08

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 57.47  E-value: 7.69e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1328 IDRLKAQLNELVNTNGRsqeQLIRLQGERDEWKRERSKVETKmvskevvrhekdpvlEKEAERLRQEVREAVQRRRATED 1407
Cdd:COG4717     48 LERLEKEADELFKPQGR---KPELNLKELKELEEELKEAEEK---------------EEEYAELQEELEELEEELEELEA 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1408 AVYELQNKLLLLERrrpEEQIVVQEVVVTQKDPKLREEHSRLsRSLDEEVGRRRQLELEVRQLGARVEEEEARLSFEEDR 1487
Cdd:COG4717    110 ELEELREELEKLEK---LLQLLPLYQELEALEAELAELPERL-EELEERLEELRELEEELEELEAELAELQEELEELLEQ 185

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1488 SKkLAAERELRQLTLKIQELEKRPPALQEKIIMEEVVKLEKDPDLERSTEALRRELDQEKNRVTELHRECQGLQVQVDLL 1567
Cdd:COG4717    186 LS-LATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAALLALLGL 264

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1568 QKTKSQEKTIYKEVIRVekdpvLEGERARVWEILNRERAARKGREEDVRSLQERIDRAEALRRSWSREEAELQRARDQAS 1647
Cdd:COG4717    265 GGSLLSLILTIAGVLFL-----VLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEEL 339

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1648 QDCGRLQRQLRELEQQKQQKARQLQEEGRLLSQK---------TESERQKAAQRSQAVTQLEAAILQEKDKIYEKERTLR 1718
Cdd:COG4717    340 LELLDRIEELQELLREAEELEEELQLEELEQEIAallaeagveDEEELRAALEQAEEYQELKEELEELEEQLEELLGELE 419

                          410       420
                   ....*....|....*....|...
gi 1907079978 1719 DLHTKVSREELNQETQTRETNLS 1741
Cdd:COG4717    420 ELLEALDEEELEEELEELEEELE 442
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 848-1724 9.66e-08

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 57.65  E-value: 9.66e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  848 KRLIQEILGREQDQATVSRLTRDLQEALQDY--ELQADTYRCSlepalavsapkrlrviSLQESIQAQEKNLAKAYTEVA 925
Cdd:COG3096    281 RELSERALELRRELFGARRQLAEEQYRLVEMarELEELSARES----------------DLEQDYQAASDHLNLVQTALR 344

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  926 AAEQQQLRQLEFAKKMLRKKELDEDIQAIHSARQGSGSPAHARTAESEVLKTQLeeerkrvAEVQRDLEEQRQRLLQLrt 1005
Cdd:COG3096    345 QQEKIERYQEDLEELTERLEEQEEVVEEAAEQLAEAEARLEAAEEEVDSLKSQL-------ADYQQALDVQQTRAIQY-- 415

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1006 QQPVARLEEKEvvEFYRDPQLEsnlsqaasrVEEEGKRRARLQAELEAVAQKVVHLEGKRKTMQPH---------LLTKE 1076
Cdd:COG3096    416 QQAVQALEKAR--ALCGLPDLT---------PENAEDYLAAFRAKEQQATEEVLELEQKLSVADAArrqfekayeLVCKI 484

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1077 VTQIERDPGLDSQVTQL--HSEMQRLRGENGVLTARLEELKDELLALEQ-KEMNVKEKVVVKEVVKVEKDLEMVKAAQTL 1153
Cdd:COG3096    485 AGEVERSQAWQTARELLrrYRSQQALAQRLQQLRAQLAELEQRLRQQQNaERLLEEFCQRIGQQLDAAEELEELLAELEA 564

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1154 RL-----QIEEDAARRKGAKETVAKIQARIKDLEQaissvepkvivkevkkveQDPGLLKEASRLRSLLE---EEKNNNV 1225
Cdd:COG3096    565 QLeeleeQAAEAVEQRSELRQQLEQLRARIKELAA------------------RAPAWLAAQDALERLREqsgEALADSQ 626

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1226 ALARELQELQEKYRVVEKQKPKVQLQERvseifqvlpETEQEIRRLraqlqetgSKKSGVEQevekllPELEVLRAQKPV 1305
Cdd:COG3096    627 EVTAAMQQLLEREREATVERDELAARKQ---------ALESQIERL--------SQPGGAED------PRLLALAERLGG 683

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1306 VEYKEVTQEVVRHE-----------KNPEVLREIDRLKAQLNELVNTngrsQEQLIRLQGER---DEWKRERSKVETKMV 1371
Cdd:COG3096    684 VLLSEIYDDVTLEDapyfsalygpaRHAIVVPDLSAVKEQLAGLEDC----PEDLYLIEGDPdsfDDSVFDAEELEDAVV 759

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1372 SK------EVVRHEKDPVL-----EKEAERLRQEvREAVQRRRATedAVYELQnkllllerrrpeeqivvqevvvtqkdp 1440
Cdd:COG3096    760 VKlsdrqwRYSRFPEVPLFgraarEKRLEELRAE-RDELAEQYAK--ASFDVQ--------------------------- 809

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1441 klreEHSRLSRSLDEEVGRRRQL------ELEVRQLGARVEEEEARLSFEEDRSKKLAAEreLRQLTLKIQELEKRPPal 1514
Cdd:COG3096    810 ----KLQRLHQAFSQFVGGHLAVafapdpEAELAALRQRRSELERELAQHRAQEQQLRQQ--LDQLKEQLQLLNKLLP-- 881

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1515 qekiimeeVVKLEKDPDLERSTEALRRELDQEKNRVTELHRECQGLQV---QVDLLQKTKSQEKTIYKEVIRVEKdpVLE 1591
Cdd:COG3096    882 --------QANLLADETLADRLEELREELDAAQEAQAFIQQHGKALAQlepLVAVLQSDPEQFEQLQADYLQAKE--QQR 951

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1592 GERARVWEILN-RERAARKGREEDVRSLQERIDRAEALRRSWSREEAELQRARDQASQDCGRL----------------- 1653
Cdd:COG3096    952 RLKQQIFALSEvVQRRPHFSYEDAVGLLGENSDLNEKLRARLEQAEEARREAREQLRQAQAQYsqynqvlaslkssrdak 1031

                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907079978 1654 QRQLRELEQQKQQKARQLQE--EGRLLSQKTESE---RQKAAQRSQAVTQL---EAAILQEKDKIYEKERTLRDLHTKV 1724
Cdd:COG3096   1032 QQTLQELEQELEELGVQADAeaEERARIRRDELHeelSQNRSRRSQLEKQLtrcEAEMDSLQKRLRKAERDYKQEREQV 1110
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1531-1740 1.39e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 57.23  E-value: 1.39e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1531 DLERSTEALRRELDQEK--NRVTELHRECQGLQVQVDLLQktksQEKTIYKEVIRVEKDPVLEGERARVWEILNRERAAR 1608
Cdd:COG4913    236 DLERAHEALEDAREQIEllEPIRELAERYAAARERLAELE----YLRAALRLWFAQRRLELLEAELEELRAELARLEAEL 311

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1609 KGREEDVRSLQERIDRAEALRRS--------WSREEAELQRARDQASQDCGRLQRQLRELEQQKQQKARQLQEEGRLLSQ 1680
Cdd:COG4913    312 ERLEARLDALREELDELEAQIRGnggdrleqLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAALRAEAAA 391

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907079978 1681 KTESERQKAAQRSQAVTQLEAAILQEKDKIYEKERTLRDLHTKVS---------REELNQETQTRETNL 1740
Cdd:COG4913    392 LLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSniparllalRDALAEALGLDEAEL 460
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 228-358 3.03e-07

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 53.22  E-value: 3.03e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  228 LYTHLQGCTKQLSALADQQGRILQQDwsDLMPDPAGVRREYEHFK--QHELLAQERSINQLEDDADRMVELGHPAIGPIQ 305
Cdd:cd00176      1 KLQQFLRDADELEAWLSEKEELLSST--DYGDDLESVEALLKKHEalEAELAAHEERVEALNELGEQLIEEGHPDAEEIQ 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1907079978  306 VHQEALKMEWQNFLNLCICQESQLQRVEDYRRFQEEADSVSQTLAKLSSNLDT 358
Cdd:cd00176     79 ERLEELNQRWEELRELAEERRQRLEEALDLQQFFRDADDLEQWLEEKEAALAS 131
PLEC smart00250
Plectin repeat;
1952-1989 3.21e-07

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 48.25  E-value: 3.21e-07
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1907079978  1952 QRLLNAQKAFTGIEDPVTRKRLSVGEAIQKGWMPQESV 1989
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1260-1738 5.41e-07

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 55.05  E-value: 5.41e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1260 VLPETEQEIRRLRAQLQETGSKK-----SGVEQEVEKLLPELEVLRAQKP-VVEYKEVTQEVV-RHEknpEVLREIDRLK 1332
Cdd:PRK02224   181 VLSDQRGSLDQLKAQIEEKEEKDlherlNGLESELAELDEEIERYEEQREqARETRDEADEVLeEHE---ERREELETLE 257

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1333 AQLNELVNT-----------NGRSQEQLIRLQGERDEWKRERSKVETKMVSKEVVRHEKDPvLEKEAERLRQEVREA-VQ 1400
Cdd:PRK02224   258 AEIEDLRETiaeterereelAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREE-LEDRDEELRDRLEECrVA 336

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1401 RRRATEDAVYELQNKLLLLERRRpeeqivvqevvvtqkdpKLREEHSRLSRSLD---EEVGRRR----QLELEVRQLGAR 1473
Cdd:PRK02224   337 AQAHNEEAESLREDADDLEERAE-----------------ELREEAAELESELEearEAVEDRReeieELEEEIEELRER 399

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1474 VEEEEARLSFEEDRSKKLAAERE-----LRQLTLKIQELEKRPPALQEkiIMEEVVKLEKDPDLERSTEALRRELDQEkn 1548
Cdd:PRK02224   400 FGDAPVDLGNAEDFLEELREERDelrerEAELEATLRTARERVEEAEA--LLEAGKCPECGQPVEGSPHVETIEEDRE-- 475

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1549 RVTELHRECQGLQVQVDLLQKtksqektiykeviRVEKDPVLEGERARVWEILNRERAARKGREEDVRSLQERIDRAEAL 1628
Cdd:PRK02224   476 RVEELEAELEDLEEEVEEVEE-------------RLERAEDLVEAEDRIERLEERREDLEELIAERRETIEEKRERAEEL 542

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1629 RRSWSREEAELQRARDQAS---QDCGRLQRQLRELEQQKQQKARQLQEEGRLLSQKTESE--RQKAAQRSQAVTQLEAAI 1703
Cdd:PRK02224   543 RERAAELEAEAEEKREAAAeaeEEAEEAREEVAELNSKLAELKERIESLERIRTLLAAIAdaEDEIERLREKREALAELN 622

                          490       500       510
                   ....*....|....*....|....*....|....*
gi 1907079978 1704 LQEKDKIYEKERTLRDLHTKVSREELNQETQTRET 1738
Cdd:PRK02224   623 DERRERLAEKRERKRELEAEFDEARIEEAREDKER 657
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
906-1404 6.58e-07

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 54.68  E-value: 6.58e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  906 LQESIQAQEKNLAKAYTEVAAAEQQqLRQLEFAKKMLRK--KELDEDIQAIHSARQGSGSpahaRTAESEVLKTQLEEER 983
Cdd:PRK03918   191 IEELIKEKEKELEEVLREINEISSE-LPELREELEKLEKevKELEELKEEIEELEKELES----LEGSKRKLEEKIRELE 265

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  984 KRVAEVQRDLEEQRQRLLQLRTQQPVArLEEKEVVEFYRDP-QLESNLSQAASRVEEEGKRRARLQAELEAVAQKVVHLE 1062
Cdd:PRK03918   266 ERIEELKKEIEELEEKVKELKELKEKA-EEYIKLSEFYEEYlDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELK 344

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1063 GKRKTMQphlltKEVTQIERDPGLDSQVTQLHSEMQRLRGENGVLTarLEELKDELLALEQ---------KEMNVKEKVV 1133
Cdd:PRK03918   345 KKLKELE-----KRLEELEERHELYEEAKAKKEELERLKKRLTGLT--PEKLEKELEELEKakeeieeeiSKITARIGEL 417

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1134 VKEVVKVEKDLEMVKAAQ--------------------TLRLQIEEDAARRKGAKETVAKIQARIKDLEQAIS------- 1186
Cdd:PRK03918   418 KKEIKELKKAIEELKKAKgkcpvcgrelteehrkelleEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKkeselik 497

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1187 ---------SVEPKVIVKEVKKVEQDP-----------GLLKEASRLRSLLEEEKnnnvALARELQELQEKYRVVEKQKP 1246
Cdd:PRK03918   498 lkelaeqlkELEEKLKKYNLEELEKKAeeyeklkekliKLKGEIKSLKKELEKLE----ELKKKLAELEKKLDELEEELA 573

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1247 KV-------------QLQERVSE-------------IFQVLPETEQEIRRLRAQLQETGSKKSGVEQEVEKLLPELEVLR 1300
Cdd:PRK03918   574 ELlkeleelgfesveELEERLKElepfyneylelkdAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELE 653

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1301 AQKPVVEYKEVTQEVVRHEknpevlREIDRLKAQLNELvntnGRSQEQLIRLQGERDEWKRERSKVEtkmvskevvrhEK 1380
Cdd:PRK03918   654 KKYSEEEYEELREEYLELS------RELAGLRAELEEL----EKRREEIKKTLEKLKEELEEREKAK-----------KE 712

                          570       580
                   ....*....|....*....|....
gi 1907079978 1381 DPVLEKEAERLrQEVREAVQRRRA 1404
Cdd:PRK03918   713 LEKLEKALERV-EELREKVKKYKA 735
mukB PRK04863
chromosome partition protein MukB;
905-1736 8.33e-07

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 54.58  E-value: 8.33e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  905 SLQESIQAQEKNLAKAYTEVAAAEQQQLRQLEFAKKMLRkkeLDEDIQAIHSAR-QGSGSPAHARTAESEV--LKTQLee 981
Cdd:PRK04863   325 DLEQDYQAASDHLNLVQTALRQQEKIERYQADLEELEER---LEEQNEVVEEADeQQEENEARAEAAEEEVdeLKSQL-- 399

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  982 erkrvAEVQRDLEEQRQRLLQLrtQQPVARLEEKEvvEFYRDPQLEsnLSQAASRVEEegkrrarLQAELEAVAQKVVHL 1061
Cdd:PRK04863   400 -----ADYQQALDVQQTRAIQY--QQAVQALERAK--QLCGLPDLT--ADNAEDWLEE-------FQAKEQEATEELLSL 461

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1062 EGKRKTMQPH---------LLTKEVTQIERdpgldSQVTQLHSEMQRLRGENGVLTARLEELKDELLALEQKEMNVKEKV 1132
Cdd:PRK04863   462 EQKLSVAQAAhsqfeqayqLVRKIAGEVSR-----SEAWDVARELLRRLREQRHLAEQLQQLRMRLSELEQRLRQQQRAE 536

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1133 VVKEVVKVEKDLEMVKAAQTLRLQIEEDAaRRKGAKETVAKIQARIKDLEQAissvepkvivkevkkveqdpglLKEasr 1212
Cdd:PRK04863   537 RLLAEFCKRLGKNLDDEDELEQLQEELEA-RLESLSESVSEARERRMALRQQ----------------------LEQ--- 590

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1213 lrslLEEEKNNNVALARELQELQEKYRVVEKQKPKVQL-QERVSEIFQVLPETEQEIRRLRAQLQEtgsKKSGVEQEVEK 1291
Cdd:PRK04863   591 ----LQARIQRLAARAPAWLAAQDALARLREQSGEEFEdSQDVTEYMQQLLERERELTVERDELAA---RKQALDEEIER 663

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1292 L-------LPELEVLRAQKPVVEYKEVTQEVVRHE-----------KNPEVLREIDRLKAQLNELVNTngrsQEQLIRLQ 1353
Cdd:PRK04863   664 LsqpggseDPRLNALAERFGGVLLSEIYDDVSLEDapyfsalygpaRHAIVVPDLSDAAEQLAGLEDC----PEDLYLIE 739

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1354 GERDEWKRERSKVET--KMVSKEVV-------RHEKDPVL-----EKEAERLRQEvREAVQRRRATEDA-VYELQnklll 1418
Cdd:PRK04863   740 GDPDSFDDSVFSVEEleKAVVVKIAdrqwrysRFPEVPLFgraarEKRIEQLRAE-REELAERYATLSFdVQKLQ----- 813

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1419 lerrrpeeqivvqevvvtqkdpklreehsRLSRSLDEEVGRRRQL------ELEVRQLGARVEEEEARLSfeEDRSKKLA 1492
Cdd:PRK04863   814 -----------------------------RLHQAFSRFIGSHLAVafeadpEAELRQLNRRRVELERALA--DHESQEQQ 862

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1493 AERELRQLTLKIQELEKRPPA---LQEKIIMEEVVKLEKDpdLERSTEAlRRELDQEKNRVTELHRecqglqvQVDLLQK 1569
Cdd:PRK04863   863 QRSQLEQAKEGLSALNRLLPRlnlLADETLADRVEEIREQ--LDEAEEA-KRFVQQHGNALAQLEP-------IVSVLQS 932

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1570 TKSQEKTIYKEVIRVEKDpvLEGERARVWEILN-RERAARKGREEDVRSLQERIDRAEALRRSWSREEAELQRARDQASQ 1648
Cdd:PRK04863   933 DPEQFEQLKQDYQQAQQT--QRDAKQQAFALTEvVQRRAHFSYEDAAEMLAKNSDLNEKLRQRLEQAEQERTRAREQLRQ 1010

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1649 DcgrlQRQLRELEQ--QKQQKARQLQEEgrllsQKTESERQKAAQRSQAVTQLEAAILQEKDKIYEKERTLRD----LHT 1722
Cdd:PRK04863  1011 A----QAQLAQYNQvlASLKSSYDAKRQ-----MLQELKQELQDLGVPADSGAEERARARRDELHARLSANRSrrnqLEK 1081

                          890
                   ....*....|....
gi 1907079978 1723 KVSREELNQETQTR 1736
Cdd:PRK04863  1082 QLTFCEAEMDNLTK 1095
PLEC smart00250
Plectin repeat;
1914-1947 9.45e-07

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 47.09  E-value: 9.45e-07
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1907079978  1914 QKLLEAQAATGGIVDLLSRERYSVHKAVERGLIE 1947
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLID 34
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 921-1685 9.72e-07

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 54.20  E-value: 9.72e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  921 YTEVAAAEQQQLRQLEfAKKMLRKKELDEDIQAIHSARQGSGSPAHARTAESEVLKTQLEEERKRVAEVQRDLEEQRQRL 1000
Cdd:TIGR00618  178 YTQLALMEFAKKKSLH-GKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQKREAQEEQL 256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1001 -LQLRTQQPVARLEEKEVVE-FYRDPQLESNLSQAASRVEEEGKRRARLQAELEAVAQKVVHLEGKRKT--MQPHLLTKE 1076
Cdd:TIGR00618  257 kKQQLLKQLRARIEELRAQEaVLEETQERINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKllMKRAAHVKQ 336

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1077 VTQIERDPGLdsqVTQLHSEMQRLRGENGVLTARLEElKDELLALEQKemnvkekvVVKEVVKVEKDLEMVKAAQTLRLQ 1156
Cdd:TIGR00618  337 QSSIEEQRRL---LQTLHSQEIHIRDAHEVATSIREI-SCQQHTLTQH--------IHTLQQQKTTLTQKLQSLCKELDI 404

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1157 IEEDAArrkgakeTVAKIQARIKDLEQAISSVEPKVIVKevkkveqdpglLKEASRLRSLLEEEKNNNVALARELQELQE 1236
Cdd:TIGR00618  405 LQREQA-------TIDTRTSAFRDLQGQLAHAKKQQELQ-----------QRYAELCAAAITCTAQCEKLEKIHLQESAQ 466

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1237 KYRVVEKQ-KPKVQLQERVSEIfqvlpETEQEIRRLRAQLQETGSKKSGVEQEVEK---LLPELEVLRAQKPVVEYKEVT 1312
Cdd:TIGR00618  467 SLKEREQQlQTKEQIHLQETRK-----KAVVLARLLELQEEPCPLCGSCIHPNPARqdiDNPGPLTRRMQRGEQTYAQLE 541

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1313 QEV--VRHEKNPEvLREIDRLKAQLNELVNTNGRSQEQLIRLQGERDEWKRErsKVETKMVSKEVVRHEKDPVLEKEAER 1390
Cdd:TIGR00618  542 TSEedVYHQLTSE-RKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNI--TVRLQDLTEKLSEAEDMLACEQHALL 618

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1391 LRQEVREAVQRRRATEDAV-YELQNKLLLLERRRPEEQIVVQevvvtqkdpklrEEHSRLSRSLDEEVGRRRQLELEvrq 1469
Cdd:TIGR00618  619 RKLQPEQDLQDVRLHLQQCsQELALKLTALHALQLTLTQERV------------REHALSIRVLPKELLASRQLALQ--- 683

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1470 lgarveeeearlsfeedrskklAAERELRQLTLKIQELEKRPPALQEkiimEEVVKLEKDP---DLERSTEALRRELDQE 1546
Cdd:TIGR00618  684 ----------------------KMQSEKEQLTYWKEMLAQCQTLLRE----LETHIEEYDRefnEIENASSSLGSDLAAR 737

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1547 KNRVTELHRECQGLQVQVdLLQKTKSQEKTIYKEVIRVEKDPVLEgERARVWEILNRERAARKGREEDVRS-LQERIDRA 1625
Cdd:TIGR00618  738 EDALNQSLKELMHQARTV-LKARTEAHFNNNEEVTAALQTGAELS-HLAAEIQFFNRLREEDTHLLKTLEAeIGQEIPSD 815

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907079978 1626 EALR----RSWSREEAELQRARDQASQDCGRLQRQLRELEQQKQQKARQLQEEGRLLSQKTESE 1685
Cdd:TIGR00618  816 EDILnlqcETLVQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEQAKIIQLSDKLN 879
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
870-1411 1.56e-06

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 53.51  E-value: 1.56e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  870 DLQEALQDYELQADTYRCSLEPALAVSAPKRLRvislQESIQAQEKNLAKAYTEVAAAEqqqlRQLEFAKKMLRkkELDE 949
Cdd:PRK02224   217 ELDEEIERYEEQREQARETRDEADEVLEEHEER----REELETLEAEIEDLRETIAETE----REREELAEEVR--DLRE 286

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  950 DIQAIHSARQGSGSPAHARTAESEVLKTQLEEERKRVAEVQRDLEEQRQRLLQLRTQ-----QPVARLEEKEVVEFYRDP 1024
Cdd:PRK02224   287 RLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEECRVAAQAHNEEaeslrEDADDLEERAEELREEAA 366

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1025 QLESNLSQAASRVEEEGKRRARLQAELEAVAQKVvhlegkrktmqphlltkEVTQIERDpGLDSQVTQLHSEMQRLRGEN 1104
Cdd:PRK02224   367 ELESELEEAREAVEDRREEIEELEEEIEELRERF-----------------GDAPVDLG-NAEDFLEELREERDELRERE 428

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1105 GVLTARLEELKDELLALEQkemnVKEKVVVKEVVKVEKDLEMVKAAQTLRLQIEEDAARRKGAKETVAKIQARIKDLEQA 1184
Cdd:PRK02224   429 AELEATLRTARERVEEAEA----LLEAGKCPECGQPVEGSPHVETIEEDRERVEELEAELEDLEEEVEEVEERLERAEDL 504

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1185 ------ISSVEPKVIVKEVKKVEQDPGLLKEASRLRSLLEEEKnnnvALARELQELQEKYRVVEKQKPKVqlQERVSEIF 1258
Cdd:PRK02224   505 veaedrIERLEERREDLEELIAERRETIEEKRERAEELRERAA----ELEAEAEEKREAAAEAEEEAEEA--REEVAELN 578

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1259 QVLPETEQEIRRLRAqLQETGSKKSGVEQEVEKLLPELEVLRAQKPvvEYKEVTQEvvRHEKNPEVLREIDrlKAQLNEL 1338
Cdd:PRK02224   579 SKLAELKERIESLER-IRTLLAAIADAEDEIERLREKREALAELND--ERRERLAE--KRERKRELEAEFD--EARIEEA 651

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907079978 1339 VNTNGRSQEQLIRLQGERDEWKRERSKVETK--MVSKEVvrhekdpvleKEAERLRQEvREAVQRRRATEDAVYE 1411
Cdd:PRK02224   652 REDKERAEEYLEQVEEKLDELREERDDLQAEigAVENEL----------EELEELRER-REALENRVEALEALYD 715
PRK09039 PRK09039
peptidoglycan -binding protein;
1590-1723 1.74e-06

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 52.28  E-value: 1.74e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1590 LEGERARVWEILNRERAARKGREEDVRSLQERIDRAEALRRSWSREEAELQRARDQASQDCGRLQRQLRELEQQKQQKAR 1669
Cdd:PRK09039    58 LNSQIAELADLLSLERQGNQDLQDSVANLRASLSAAEAERSRLQALLAELAGAGAAAEGRAGELAQELDSEKQVSARALA 137

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907079978 1670 QLQeegrLLSQkteserQKAAQRSQaVTQLEAAILQEKDKIYEKERTLRDLHTK 1723
Cdd:PRK09039   138 QVE----LLNQ------QIAALRRQ-LAALEAALDASEKRDRESQAKIADLGRR 180
PTZ00121 PTZ00121
MAEBL; Provisional
 881-1327 3.01e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 52.84  E-value: 3.01e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  881 QADTYRCSLEPALAVSAPKRLRVISLQESIQAQEKNLAKAYTEVAAAEQQQLRQLEFAKKMLRKKELDEDIQAIHSARQG 960
Cdd:PTZ00121  1367 EAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKA 1446

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  961 SGSPAHARTA-ESEVLKTQLEEERKrVAEVQRDLEEQRqrllqlRTQQPVARLEE-KEVVEFYRDPQLESNLSQAASRVE 1038
Cdd:PTZ00121  1447 DEAKKKAEEAkKAEEAKKKAEEAKK-ADEAKKKAEEAK------KADEAKKKAEEaKKKADEAKKAAEAKKKADEAKKAE 1519

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1039 EEGKRRARLQAELEAVAQKVVHLEGKRKtmqphllTKEVTQIErdpgldsqvtqlhsEMQRLRGENGVLTARLEElKDEL 1118
Cdd:PTZ00121  1520 EAKKADEAKKAEEAKKADEAKKAEEKKK-------ADELKKAE--------------ELKKAEEKKKAEEAKKAE-EDKN 1577

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1119 LALEQKEMNVKEKVVVKEVVKVEKDLEMVKAAQTLRlqiEEDAARRKGakETVAKIQARIKDLEQAISSVEPKVIVKEVK 1198
Cdd:PTZ00121  1578 MALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAK---KAEEAKIKA--EELKKAEEEKKKVEQLKKKEAEEKKKAEEL 1652

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1199 KVEQDPGLLKEASRLRSLLEEEKNnnvalARELQELQEKYRVVEKQKPKVQLQERVSEifQVLPETEQEIRR---LRAQL 1275
Cdd:PTZ00121  1653 KKAEEENKIKAAEEAKKAEEDKKK-----AEEAKKAEEDEKKAAEALKKEAEEAKKAE--ELKKKEAEEKKKaeeLKKAE 1725

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1907079978 1276 QETGSKKSGVEQEVEKLLPELEVLRAQKPvvEYKEVTQEVVRHEKNPEVLRE 1327
Cdd:PTZ00121  1726 EENKIKAEEAKKEAEEDKKKAEEAKKDEE--EKKKIAHLKKEEEKKAEEIRK 1775
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
694-1075 3.70e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 52.08  E-value: 3.70e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  694 LEKQIQEADRVIQGFEAALALEGPVPEGSgALQERVSELQRQRKELLQQQACVLGLHRQLKATEHACSALQNNFQEFCQD 773
Cdd:COG4717    107 LEAELEELREELEKLEKLLQLLPLYQELE-ALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQ 185

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  774 L-PRQQRQVRALTDRYHAVGDQLDLREKIVQDASLTYQQLRNSRDNLSSWLEQLPHHR---------------------- 830
Cdd:COG4717    186 LsLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEErlkearlllliaaallallglg 265

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  831 VQPSDGPSQISYKLQAQKRLI----------QEILGREQDQATVSRLTRDLQEALQDYELQADTYRCSLEPALAVSAPKR 900
Cdd:COG4717    266 GSLLSLILTIAGVLFLVLGLLallflllareKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDR 345

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  901 LRviSLQESIQAQEKNLAKAYTEVAAAEQQQLRQL-------EFAKKMLRKKELDEDIQAIHSARQ-----GSGSPAHAR 968
Cdd:COG4717    346 IE--ELQELLREAEELEEELQLEELEQEIAALLAEagvedeeELRAALEQAEEYQELKEELEELEEqleelLGELEELLE 423

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  969 TAESEVLKTQLEEERKRVAEVQRDLEEQRQRLLQLRTQqpVARLEEKEVVEfyrdpQLESNLSQAASRVEEEGKRRARLQ 1048
Cdd:COG4717    424 ALDEEELEEELEELEEELEELEEELEELREELAELEAE--LEQLEEDGELA-----ELLQELEELKAELRELAEEWAALK 496

                          410       420
                   ....*....|....*....|....*..
gi 1907079978 1049 AELEAVAQkvvHLEGKRKTMQPHLLTK 1075
Cdd:COG4717    497 LALELLEE---AREEYREERLPPVLER 520
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 861-1742 4.62e-06

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 51.97  E-value: 4.62e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  861 QATVSRLTRDLQEALQDYELQADTYRCSLEPALAVsapkRLRVISlQESIQAQEKNLAKAYTEvaAAEQQQLRQLEFAKK 940
Cdd:TIGR00606  188 LETLRQVRQTQGQKVQEHQMELKYLKQYKEKACEI----RDQITS-KEAQLESSREIVKSYEN--ELDPLKNRLKEIEHN 260

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  941 MLRKKELDEDIQAIHSarqgsgspahaRTAESEVLKTQLEEERKRV----AEVQRDLEEQRQRllqlrtqqpVARLEEKE 1016
Cdd:TIGR00606  261 LSKIMKLDNEIKALKS-----------RKKQMEKDNSELELKMEKVfqgtDEQLNDLYHNHQR---------TVREKERE 320

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1017 VVEFYRDPQLESNLSQAASRVEEEGK-RRARLQAELEAVAQKVVHLEGKRKTMQPHLltkEVTQIERDPGLDSQVTQLHS 1095
Cdd:TIGR00606  321 LVDCQRELEKLNKERRLLNQEKTELLvEQGRLQLQADRHQEHIRARDSLIQSLATRL---ELDGFERGPFSERQIKNFHT 397

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1096 -EMQRLRGENGVLTARLEELKDELlALEQKEMNVKEKVVVKEVVKVEKDLEMV-KAAQTLRLQIEEDAARRKGAKETVAK 1173
Cdd:TIGR00606  398 lVIERQEDEAKTAAQLCADLQSKE-RLKQEQADEIRDEKKGLGRTIELKKEILeKKQEELKFVIKELQQLEGSSDRILEL 476

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1174 IQARIKDLEQAI-----SSVEPKVIVKEVKKVEQ---DPGLLKEASRLRSL--LEEEKNNNVALARELQELQEKYRVVEK 1243
Cdd:TIGR00606  477 DQELRKAERELSkaeknSLTETLKKEVKSLQNEKadlDRKLRKLDQEMEQLnhHTTTRTQMEMLTKDKMDKDEQIRKIKS 556

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1244 QKP------------KVQLQERVSEIFQVLPETEQEIRRLRAQLQETGSKKSGVEQEVEKLLPEL--------EVLRAQK 1303
Cdd:TIGR00606  557 RHSdeltsllgyfpnKKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLssyedklfDVCGSQD 636

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1304 PVVEYKEVTQEVVRHEKNPEVLREIDRLKAQ-LNELVNTNGRSQEQLIRLQGERDEWKRERSKVETKMVSKEVVRHEKDP 1382
Cdd:TIGR00606  637 EESDLERLKEEIEKSSKQRAMLAGATAVYSQfITQLTDENQSCCPVCQRVFQTEAELQEFISDLQSKLRLAPDKLKSTES 716

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1383 VLEKEaERLRQEVREAVQRRRA----TEDAVYELQNKLLLLERRRPEEQIVVQEVVVTQKDPKLREEHSRLSRSlDEEVG 1458
Cdd:TIGR00606  717 ELKKK-EKRRDEMLGLAPGRQSiidlKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLT-DVTIM 794

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1459 RRRQLELE-----VRQLGARVEEEEARLSFEEDRSKKLAAERELRQLTLKIQELEKRPPALQEKII-MEEVVKLEKDPDL 1532
Cdd:TIGR00606  795 ERFQMELKdverkIAQQAAKLQGSDLDRTVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQhLKSKTNELKSEKL 874

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1533 ERSTEALRREldQEKNRVTELHRECQGLQVQVDLLQKTKSQEKTiykevirvekdpVLEGERARVWEILNRERAARKGRE 1612
Cdd:TIGR00606  875 QIGTNLQRRQ--QFEEQLVELSTEVQSLIREIKDAKEQDSPLET------------FLEKDQQEKEELISSKETSNKKAQ 940

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1613 EDVRSLQERIDRAEALRRSWSREEAE-LQRARDQASQDCGRLQRQLRELEQQKQqkarQLQEEGRLLSQKTESERQKaaq 1691
Cdd:TIGR00606  941 DKVNDIKEKVKNIHGYMKDIENKIQDgKDDYLKQKETELNTVNAQLEECEKHQE----KINEDMRLMRQDIDTQKIQ--- 1013

                          890       900       910       920       930
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907079978 1692 rsQAVTQLEAAILQEKDKIYEKERTLRDLHTKVSRE---ELNQETQTRETNLST 1742
Cdd:TIGR00606 1014 --ERWLQDNLTLRKRENELKEVEEELKQHLKEMGQMqvlQMKQEHQKLEENIDL 1065
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1206-1794 4.67e-06

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 51.90  E-value: 4.67e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1206 LLKEASRLRSLLEEEKNNNvALARELQELQEK---YRVVEKQKPKVQLQERVSEIFQVLPETEQEIRRLRAQLQETGSKK 1282
Cdd:pfam02463  158 IEEEAAGSRLKRKKKEALK-KLIEETENLAELiidLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNE 236

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1283 SGVEQEVEKLLPELEVLRA--QKPVVEYKEVTQEVVRHEKNPEVLREIDRLKAQLNELVNTNgRSQEQLIRLQGERDEWK 1360
Cdd:pfam02463  237 ERIDLLQELLRDEQEEIESskQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEEL-KSELLKLERRKVDDEEK 315

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1361 RERSKVETKMVSKEVVRHEK----DPVLEKEAERLRQEVREAVQRRRATEDAVYELQNKLLLLERRRPEEQIVVQEVVVT 1436
Cdd:pfam02463  316 LKESEKEKKKAEKELKKEKEeieeLEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEE 395

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1437 QKDPKLREEHSRLSRsLDEEVGRRRQLELEVRQLGARVEEEEARLSFEEDRSKKLAAERELRQLTLKIQELEKRPPALQE 1516
Cdd:pfam02463  396 ELELKSEEEKEAQLL-LELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLL 474

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1517 KIIMEEVVKLEKDPDLERSTEALRRELDQEKNRVTELHRECQGLQVQVDLLQKTKSQEKTIY----KEVIRVEKDPVLEG 1592
Cdd:pfam02463  475 KETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVavenYKVAISTAVIVEVS 554

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1593 ERARVWEILNRERAARKGREEDVRSLQERIDRAEALRRSWSREE--AELQRARDQASQDCGRLQRQLRELEQQKQQKARQ 1670
Cdd:pfam02463  555 ATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEidPILNLAQLDKATLEADEDDKRAKVVEGILKDTEL 634

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1671 LQEEGRLLSQKTESERQKAAQRSQAVTQLEAAILQEKDKIY-------EKERTLRDLHTKVSREELNQETQTRETNLSTK 1743
Cdd:pfam02463  635 TKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELleiqelqEKAESELAKEEILRRQLEIKKKEQREKEELKK 714

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1907079978 1744 ICILEPETGNDMSPYEAYKRGVIDRGQYLQLQELECDWEEVTTSSPCGEES 1794
Cdd:pfam02463  715 LKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEE 765
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
851-1073 5.23e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 51.84  E-value: 5.23e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  851 IQEILGREQDQATVSRLTRDLQEALQDYELQADTYRCSLEPALAVSApkRLRVISLQESIQAQEKNLAKAYTEVAAAEQQ 930
Cdd:COG4913    240 AHEALEDAREQIELLEPIRELAERYAAARERLAELEYLRAALRLWFA--QRRLELLEAELEELRAELARLEAELERLEAR 317

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  931 QlrqlefakkmlrkKELDEDIQAIHSARQGSGspaharTAESEVLKTQLEEERKRVAEVQRDLEEQRQRLLQLRTQQPva 1010
Cdd:COG4913    318 L-------------DALREELDELEAQIRGNG------GDRLEQLEREIERLERELEERERRRARLEALLAALGLPLP-- 376

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907079978 1011 rLEEKEVVEFYRD-----PQLESNLSQAASRVEEEGKRRARLQAELEAVAQKVVHLEGKRKTMQPHLL 1073
Cdd:COG4913    377 -ASAEEFAALRAEaaallEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLL 443
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1145-1732 1.71e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 50.02  E-value: 1.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1145 EMVKAAQTLRLQIEEDAARRKGAKETVAKIQARIKDLEQAISSVEPKVIVKEVKKVEQDPGLLKEASRLRSLLEEEKNNN 1224
Cdd:TIGR04523   37 QLEKKLKTIKNELKNKEKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDK 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1225 ---VALARELQELQEKYRVVEKQKPKVqlqerVSEIF---QVLPETEQEIRRLRAQLQETGSKKSGVEQEVEKLLPELEV 1298
Cdd:TIGR04523  117 eqkNKLEVELNKLEKQKKENKKNIDKF-----LTEIKkkeKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDK 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1299 LRAQKPVVEYKeVTQEVVRHEKNPEVLREIDRLKAQLNELvntngrsQEQLIRLQGERDEWKRERSKVETKM-VSKEVVR 1377
Cdd:TIGR04523  192 IKNKLLKLELL-LSNLKKKIQKNKSLESQISELKKQNNQL-------KDNIEKKQQEINEKTTEISNTQTQLnQLKDEQN 263

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1378 HEKDPVLEKEaerlrQEVREAVQRRRATEDAVYELQNKLLLLERRRPEEQIVVQEVVVTQKDPKLREEHSRLSRSLDeev 1457
Cdd:TIGR04523  264 KIKKQLSEKQ-----KELEQNNKKIKELEKQLNQLKSEISDLNNQKEQDWNKELKSELKNQEKKLEEIQNQISQNNK--- 335

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1458 gRRRQLELEVRQLgarveEEEARLSFEEDRSKKlaaerelRQLTLKIQELEKrppalqekIIMEEVVKLEKDPDLERSTE 1537
Cdd:TIGR04523  336 -IISQLNEQISQL-----KKELTNSESENSEKQ-------RELEEKQNEIEK--------LKKENQSYKQEIKNLESQIN 394

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1538 ALRRELDQEKNRVTELHRECQGLQVQVDLLQKtksqEKTIYKEVIRVEKDPVLEgerarvweiLNRERAARkgrEEDVRS 1617
Cdd:TIGR04523  395 DLESKIQNQEKLNQQKDEQIKKLQQEKELLEK----EIERLKETIIKNNSEIKD---------LTNQDSVK---ELIIKN 458

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1618 LQERIDRAEALRRSWSREEAELQRARDQASQDcgrLQRQLRELEQQKQQKaRQLQEEGRLLSQKTESERQKAAQRSQAVT 1697
Cdd:TIGR04523  459 LDNTRESLETQLKVLSRSINKIKQNLEQKQKE---LKSKEKELKKLNEEK-KELEEKVKDLTKKISSLKEKIEKLESEKK 534

                          570       580       590
                   ....*....|....*....|....*....|....*
gi 1907079978 1698 QLEAAILQEKDKIYEKERTLRDLHTKVSREELNQE 1732
Cdd:TIGR04523  535 EKESKISDLEDELNKDDFELKKENLEKEIDEKNKE 569
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1088-1581 1.74e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 50.02  E-value: 1.74e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1088 SQVTQLHSEMQRLRGENGVLTARLEELKDELLALE------QKEMNVKEKVVVKEVVKVEKDLEMVKAAQTLRLQIEEDA 1161
Cdd:TIGR04523  145 TEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEkeklniQKNIDKIKNKLLKLELLLSNLKKKIQKNKSLESQISELK 224

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1162 ARRKGAKETVAKIQARIKDLEQAISSVEpkviVKEVKKVEQDPGLLKEASRLRSLLEEEKNNNVALARELQELQEKYRVV 1241
Cdd:TIGR04523  225 KQNNQLKDNIEKKQQEINEKTTEISNTQ----TQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEISDL 300

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1242 EKQK-----------------PKVQLQERVSEIFQVLPETEQEIRRLRAQLQETGSKKSGVEQEVEKLLPELEVLRAQkp 1304
Cdd:TIGR04523  301 NNQKeqdwnkelkselknqekKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKE-- 378

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1305 vveykevtqevvrhekNPEVLREIDRLKAQLNELvntngrsqEQLIRLQGERDEWKRErsKVETKMVSKEvvrhekdpVL 1384
Cdd:TIGR04523  379 ----------------NQSYKQEIKNLESQINDL--------ESKIQNQEKLNQQKDE--QIKKLQQEKE--------LL 424

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1385 EKEAERLRQEVREAVQRRRATEDAVYELQNKLLLLERRRPEEQIVVQEVVVTQKdpKLREEHSRLSRSLDEEVGRRRQLE 1464
Cdd:TIGR04523  425 EKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSIN--KIKQNLEQKQKELKSKEKELKKLN 502

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1465 LEVRQLGARVEEEEARLSFEEDRSKKLaaERELRQLTLKIQELEKrppalqEKIIMEEVVKLEKdpdLERSTEALRRELD 1544
Cdd:TIGR04523  503 EEKKELEEKVKDLTKKISSLKEKIEKL--ESEKKEKESKISDLED------ELNKDDFELKKEN---LEKEIDEKNKEIE 571

                          490       500       510
                   ....*....|....*....|....*....|....*..
gi 1907079978 1545 QEKNRVTELHRECQGLQvqvDLLQKTKSQEKTIYKEV 1581
Cdd:TIGR04523  572 ELKQTQKSLKKKQEEKQ---ELIDQKEKEKKDLIKEI 605
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1322-1516 1.95e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 49.91  E-value: 1.95e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1322 PEVLREIDRLKAQLNELVNTNGRS---QEQLIRLQGERDEWKRERSKVETKMVSKEVV-------RHEKDPVLEKEAERL 1391
Cdd:COG4913    221 PDTFEAADALVEHFDDLERAHEALedaREQIELLEPIRELAERYAAARERLAELEYLRaalrlwfAQRRLELLEAELEEL 300

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1392 RQEVREAVQRRRATEDAVYELQNKLLLLERRRpeeqivvQEVVVTQKDPkLREEHSRLSRSLDEEVGRRRQLELEVRQLG 1471
Cdd:COG4913    301 RAELARLEAELERLEARLDALREELDELEAQI-------RGNGGDRLEQ-LEREIERLERELEERERRRARLEALLAALG 372

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907079978 1472 ARV-----------------------EEEEARLSFEEDRSKKLAAERELRQLTLKIQELEKR----PPALQE 1516
Cdd:COG4913    373 LPLpasaeefaalraeaaallealeeELEALEEALAEAEAALRDLRRELRELEAEIASLERRksniPARLLA 444
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1216-1755 1.97e-05

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 49.84  E-value: 1.97e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1216 LLEEEKNNNVALARELQELQEKYRVVEKQKPKvqLQERVSEifqVLPETEQEIRRLRAQLQE----TGSKKSGVEQEVEK 1291
Cdd:pfam12128  245 KLQQEFNTLESAELRLSHLHFGYKSDETLIAS--RQEERQE---TSAELNQLLRTLDDQWKEkrdeLNGELSAADAAVAK 319

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1292 LLPELEVLRAQKPVVEYKEVTQEVVRHEKNPEVLREIDRLKAQLnELVNTNGRSQEQlirlqgerdEWKRERSKVETKMV 1371
Cdd:pfam12128  320 DRSELEALEDQHGAFLDADIETAAADQEQLPSWQSELENLEERL-KALTGKHQDVTA---------KYNRRRSKIKEQNN 389

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1372 SKEVVRHEKDPVLEKEAERLRQEVREAVQR-----RRATEDAVYELQNKLLLLERRrpeeqivVQEVVVTQKDPKLREEH 1446
Cdd:pfam12128  390 RDIAGIKDKLAKIREARDRQLAVAEDDLQAleselREQLEAGKLEFNEEEYRLKSR-------LGELKLRLNQATATPEL 462

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1447 SRLSRSLDEEVGRRRQlelevRQLGARVEEEEARLSFEEDRSKKLAAERELRQLTLKIQELEKRPPALQEKIIMEEVVKL 1526
Cdd:pfam12128  463 LLQLENFDERIERARE-----EQEAANAEVERLQSELRQARKRRDQASEALRQASRRLEERQSALDELELQLFPQAGTLL 537

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1527 E----KDPDLERSteaLRRELDQEKNRVTELHRECQGLQVqvdllqktkSQEKTIYKEVIRVEKDPVleGERARVWEILN 1602
Cdd:pfam12128  538 HflrkEAPDWEQS---IGKVISPELLHRTDLDPEVWDGSV---------GGELNLYGVKLDLKRIDV--PEWAASEEELR 603

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1603 RERAARKGREEDVRSLQERIDRAEALRR----SWSREEAELQRARDQASQDCGRLQRQLRELEQQKQQkarQLQEEGRll 1678
Cdd:pfam12128  604 ERLDKAEEALQSAREKQAAAEEQLVQANgeleKASREETFARTALKNARLDLRRLFDEKQSEKDKKNK---ALAERKD-- 678

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1679 sQKTESERQKAAQRSQAVTQLEAAILQEKDKIYEkERTLRDLHTKVSREE-------LNQETQTRETNLSTKICILEPET 1751
Cdd:pfam12128  679 -SANERLNSLEAQLKQLDKKHQAWLEEQKEQKRE-ARTEKQAYWQVVEGAldaqlalLKAAIAARRSGAKAELKALETWY 756


                   ....
gi 1907079978 1752 GNDM 1755
Cdd:pfam12128  757 KRDL 760
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 1995-2030 2.06e-05

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 43.09  E-value: 2.06e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907079978 1995 VQHLTGGLIDPKRTGRIPVPQAVLCGMISEDLGQLL 2030
Cdd:pfam00681    4 AQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
908-1470 2.07e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 49.91  E-value: 2.07e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  908 ESIQAQEKNLAKAYTEVAAAEQQ--QLRQL-----EFAKKMLRKKELDEDIQAIHS-ARQGSGSPAHARTAESEVLKTQL 979
Cdd:COG4913    228 DALVEHFDDLERAHEALEDAREQieLLEPIrelaeRYAAARERLAELEYLRAALRLwFAQRRLELLEAELEELRAELARL 307

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  980 EEERKRVAEVQRDLEEQRQRLLQLRTQQPVARLEekevvefyrdpQLESNLSQAASRVEEEGKRRARLQAELEAVAQKVV 1059
Cdd:COG4913    308 EAELERLEARLDALREELDELEAQIRGNGGDRLE-----------QLEREIERLERELEERERRRARLEALLAALGLPLP 376

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1060 HLEGKRKTMQphlltKEVTQieRDPGLDSQVTQLHSEMQRLRGENGVLTARLEELKDELLALEQKEMNVkekvvvkevvk 1139
Cdd:COG4913    377 ASAEEFAALR-----AEAAA--LLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNI----------- 438

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1140 vekDLEMVKAAQTLR----------------LQIEEDAARRKGAKETVAKIQARI-----KDLEQAISSVEP-------- 1190
Cdd:COG4913    439 ---PARLLALRDALAealgldeaelpfvgelIEVRPEEERWRGAIERVLGGFALTllvppEHYAAALRWVNRlhlrgrlv 515

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1191 ----KVIVKEVKKVEQDPG-----LLKEASRLRSLLEEE--KNNNVALARELQELQ-------------EKYRVVEKQKP 1246
Cdd:COG4913    516 yervRTGLPDPERPRLDPDslagkLDFKPHPFRAWLEAElgRRFDYVCVDSPEELRrhpraitragqvkGNGTRHEKDDR 595

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1247 KVQLQERVseIFQvlpETEQEIRRLRAQLQETGSKKSGVEQEVEKLLPELEVLRAQKPVVE-YKEVTQEVVRHeknPEVL 1325
Cdd:COG4913    596 RRIRSRYV--LGF---DNRAKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQrLAEYSWDEIDV---ASAE 667

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1326 REIDRLKAQLNELVNTNGrsqeQLIRLQGERDEWKRERSKVETKmvsKEVVRHEKDpVLEKEAERLRQEVREAVQRRRAT 1405
Cdd:COG4913    668 REIAELEAELERLDASSD----DLAALEEQLEELEAELEELEEE---LDELKGEIG-RLEKELEQAEEELDELQDRLEAA 739

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907079978 1406 EDAVYELQNklLLLERRRPEEQIvvqevvvtqkDPKLREEHSRLSRSLDEEVGRRRQLELEVRQL 1470
Cdd:COG4913    740 EDLARLELR--ALLEERFAAALG----------DAVERELRENLEERIDALRARLNRAEEELERA 792
PTZ00121 PTZ00121
MAEBL; Provisional
 906-1399 2.08e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 50.14  E-value: 2.08e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  906 LQESIQAQEKNLAKAYTEVAAAEQQQLRQLEFAKKMLRKKELDEDIQAIHSARQGSGSPAHARTAESEVLKTQLEEERKR 985
Cdd:PTZ00121  1359 AEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKK 1438

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  986 VAEVQRDLEEQRQRLLQLR-TQQPVARLEEKEVVEFYRDPQLESNLSQAASRVEEEGKRRA---RLQAELEAVAQKVVHL 1061
Cdd:PTZ00121  1439 KAEEAKKADEAKKKAEEAKkAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKAdeaKKAAEAKKKADEAKKA 1518

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1062 EGKRKtmqphllTKEVTQIERDPGLDsqvtQLHSEMQRLRGENgvlTARLEELK--DELLALEQKEMNVKEKVVVKEVVK 1139
Cdd:PTZ00121  1519 EEAKK-------ADEAKKAEEAKKAD----EAKKAEEKKKADE---LKKAEELKkaEEKKKAEEAKKAEEDKNMALRKAE 1584

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1140 VEKDLEMVKAAQTLRLQIEEDAARRKGA-KETVAKIQA-RIKDLEQAISSVEPKVIVKEVKKveqdpgllKEASRLRsll 1217
Cdd:PTZ00121  1585 EAKKAEEARIEEVMKLYEEEKKMKAEEAkKAEEAKIKAeELKKAEEEKKKVEQLKKKEAEEK--------KKAEELK--- 1653

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1218 EEEKNNNVALARELQELQEKYRVVEKQKPKVQLQERVSEIFQVLPETEQEIRRLRAQLQETGSKKSGVEQEVEKLLPELE 1297
Cdd:PTZ00121  1654 KAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAE 1733

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1298 vlRAQKPVVEYKEVTQEVvrhEKNPEVLREIDRLKAQLNELVNTNGRSQEQLIRLQGERDEWKR----ERSKVETKMVSK 1373
Cdd:PTZ00121  1734 --EAKKEAEEDKKKAEEA---KKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRrmevDKKIKDIFDNFA 1808

                          490       500
                   ....*....|....*....|....*...
gi 1907079978 1374 EVVR--HEKDPVLEKEAERLRQEVREAV 1399
Cdd:PTZ00121  1809 NIIEggKEGNLVINDSKEMEDSAIKEVA 1836
mukB PRK04863
chromosome partition protein MukB;
735-1543 2.11e-05

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 49.96  E-value: 2.11e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  735 QRKELLQQqacVLGLHRQLKATEHACSALQNNFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLrekiVQDASLTYQQLRN 814
Cdd:PRK04863   280 ERRVHLEE---ALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLEQDYQAASDHLNL----VQTALRQQEKIER 352

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  815 SRDNLSSWLEQLpHHRVQPSDGPSQISYKLQAQKRLIQEilgrEQDQATvSRLTrDLQEALQDYELQADTYR-------- 886
Cdd:PRK04863   353 YQADLEELEERL-EEQNEVVEEADEQQEENEARAEAAEE----EVDELK-SQLA-DYQQALDVQQTRAIQYQqavqaler 425

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  887 ----CSLePALAVSapkrlRVISLQESIQAQEKNLAkayTEVAAAEQQ------QLRQLEFAKKMLRKkeLDEDI---QA 953
Cdd:PRK04863   426 akqlCGL-PDLTAD-----NAEDWLEEFQAKEQEAT---EELLSLEQKlsvaqaAHSQFEQAYQLVRK--IAGEVsrsEA 494

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  954 IHSARQgsgspAHARTAESEVLKTQLEEERKRVAEVQRDLEEQR--QRLLQLRTQQPVARLEEKEVVEFYRDpQLESNLS 1031
Cdd:PRK04863   495 WDVARE-----LLRRLREQRHLAEQLQQLRMRLSELEQRLRQQQraERLLAEFCKRLGKNLDDEDELEQLQE-ELEARLE 568

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1032 QAASRVEEEGKRRARLQAELEAVAQKVVHLEGKR----------------------------KTMQPHLLTKEVTQIERD 1083
Cdd:PRK04863   569 SLSESVSEARERRMALRQQLEQLQARIQRLAARApawlaaqdalarlreqsgeefedsqdvtEYMQQLLERERELTVERD 648

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1084 pGLDSQVTQLHSEMQRLRGENGVLTARLEELKDELLALEQKEMnvkekvvvkevvkvEKDLEMVKAAQT------LRLQI 1157
Cdd:PRK04863   649 -ELAARKQALDEEIERLSQPGGSEDPRLNALAERFGGVLLSEI--------------YDDVSLEDAPYFsalygpARHAI 713

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1158 ---EEDAARRKGAK-----ETVAKIQARIKDLEQAISSVEPKVIVKEVKKVEQD---------PgLLKEASRlRSLLEEe 1220
Cdd:PRK04863   714 vvpDLSDAAEQLAGledcpEDLYLIEGDPDSFDDSVFSVEELEKAVVVKIADRQwrysrfpevP-LFGRAAR-EKRIEQ- 790

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1221 knnnvaLARELQELQEKYrvvEKQKPKVQLQERVSEIFQVL----------PETEQEIRRLRAQLQETGSKKSGVE---- 1286
Cdd:PRK04863   791 ------LRAEREELAERY---ATLSFDVQKLQRLHQAFSRFigshlavafeADPEAELRQLNRRRVELERALADHEsqeq 861

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1287 -------------QEVEKLLPELEVLRAQKPVVEYKEVTQEVVRHEKNPEVLREIDRLKAQLNELVNTNGRSQEQLIRLQ 1353
Cdd:PRK04863   862 qqrsqleqakeglSALNRLLPRLNLLADETLADRVEEIREQLDEAEEAKRFVQQHGNALAQLEPIVSVLQSDPEQFEQLK 941

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1354 GERDEWKRERSKVETKMVS-KEVVR-------HEKDPVLEKEA---ERLRQEVREAVQRRRATEDAVYELQNKLlllerr 1422
Cdd:PRK04863   942 QDYQQAQQTQRDAKQQAFAlTEVVQrrahfsyEDAAEMLAKNSdlnEKLRQRLEQAEQERTRAREQLRQAQAQL------ 1015

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1423 rpEEQIVVQEVVVTQKDPKlREEHSRLSRSLDEeVGRRRQLELEVRqLGARVEEEEARLSfeEDRSKKLAAERELRQLTL 1502
Cdd:PRK04863  1016 --AQYNQVLASLKSSYDAK-RQMLQELKQELQD-LGVPADSGAEER-ARARRDELHARLS--ANRSRRNQLEKQLTFCEA 1088

                          890       900       910       920       930
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1907079978 1503 KIQELEKRPPALQEKI-IMEE-----------VVKLEKDPDLERSTEalRREL 1543
Cdd:PRK04863  1089 EMDNLTKKLRKLERDYhEMREqvvnakagwcaVLRLVKDNGVERRLH--RREL 1139
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1466-1733 2.41e-05

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 49.68  E-value: 2.41e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1466 EVRQLGARVEEEEARLSFEEDRSKKLAAERELRqltLKIQELEKRPPALQEKIIMEEVVKLEKD-PDLERSTEALRRELD 1544
Cdd:TIGR02169  178 ELEEVEENIERLDLIIDEKRQQLERLRREREKA---ERYQALLKEKREYEGYELLKEKEALERQkEAIERQLASLEEELE 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1545 QEKNRVTELHRECQglQVQVDLLQKTKSQEKTIYKEVIRVEKD-PVLEGERARVWEILNRERAARKGREEDVRSLQERID 1623
Cdd:TIGR02169  255 KLTEEISELEKRLE--EIEQLLEELNKKIKDLGEEEQLRVKEKiGELEAEIASLERSIAEKERELEDAEERLAKLEAEID 332

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1624 RAEALRRSWSREEAELQRARDQASQDCGRLQRQLRELEQQKQQKARQLQEEGRLLSQ---------------KTESER-- 1686
Cdd:TIGR02169  333 KLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDyrekleklkreinelKRELDRlq 412

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 1907079978 1687 QKAAQRSQAVTQLEAAILQEKDKIYEKERTLRDLHTKVSREELNQET 1733
Cdd:TIGR02169  413 EELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQ 459
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1441-1702 2.50e-05

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 49.79  E-value: 2.50e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1441 KLREEHSRLSRSLDEEVGRRRQLELEVRQLGARVEEEEARLSFEEDRSKKLAAEREL-----RQLTLKIQELEKRPPAL- 1514
Cdd:pfam01576  100 KMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKERKLleeriSEFTSNLAEEEEKAKSLs 179

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1515 -----QEKIIMEEVVKLEKDPDLERSTEALRRELDQEknrVTELHRECQGLQVQV-DLLQKTKSQEKTIYKEVIRVEKDP 1588
Cdd:pfam01576  180 klknkHEAMISDLEERLKKEEKGRQELEKAKRKLEGE---STDLQEQIAELQAQIaELRAQLAKKEEELQAALARLEEET 256

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1589 V-----------LEGERARVWEILNRERAARkgreedvrslqeriDRAEALRRSWSrEEAELQRARDQASQDCGRLQRQL 1657
Cdd:pfam01576  257 AqknnalkkireLEAQISELQEDLESERAAR--------------NKAEKQRRDLG-EELEALKTELEDTLDTTAAQQEL 321

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 1907079978 1658 R-ELEQQKQQKARQLQEEGRLLSQKTESERQKAAQRSQAVT-QLEAA 1702
Cdd:pfam01576  322 RsKREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEELTeQLEQA 368
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1044-1516 2.73e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 49.38  E-value: 2.73e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1044 RARLQAELEAVAQKVVHLEGKRKTMQPHLLTKEVTQIERdpgLDSQVTQLHSEMQRLRGengvLTARLEELKDELLALEQ 1123
Cdd:COG4717     44 RAMLLERLEKEADELFKPQGRKPELNLKELKELEEELKE---AEEKEEEYAELQEELEE----LEEELEELEAELEELRE 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1124 KEMNVKEKVVVKEVVKVEKDLEMVKAAQTLRL-QIEEDAARRKGAKETVAKIQARIKDLEQAIssvEPKVIVKEVKKVEQ 1202
Cdd:COG4717    117 ELEKLEKLLQLLPLYQELEALEAELAELPERLeELEERLEELRELEEELEELEAELAELQEEL---EELLEQLSLATEEE 193

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1203 DPGLLKEASRLRSLLEEEKNNNVALARELQELQEKYRVVEKQKPKVQLQERVSE--IFQVLPETEQEIRRLRAQLQETGS 1280
Cdd:COG4717    194 LQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEarLLLLIAAALLALLGLGGSLLSLIL 273

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1281 KKSGVEQEVEKLLPELEVLRAQKPVVEYKEVTQEVVRHEKNPEVLREIDRLKAQLNELVNTNGRSQEQLIRLQGERDEWK 1360
Cdd:COG4717    274 TIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELL 353

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1361 RERSKVETKMvSKEVVRHEKDPVLEKEAERLRQEVREAVQRRRATEdavyELQNKLLLLERRRPEEQIVVQEVVVTQKDP 1440
Cdd:COG4717    354 REAEELEEEL-QLEELEQEIAALLAEAGVEDEEELRAALEQAEEYQ----ELKEELEELEEQLEELLGELEELLEALDEE 428

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1441 KLREEHSRLSRSLDEEVGRRRQLELEVRQLGARVEEEEARLSFEEDRSKKLAAERELRQL----------------TLKI 1504
Cdd:COG4717    429 ELEEELEELEEELEELEEELEELREELAELEAELEQLEEDGELAELLQELEELKAELRELaeewaalklalelleeAREE 508

                          490
                   ....*....|..
gi 1907079978 1505 QELEKRPPALQE 1516
Cdd:COG4717    509 YREERLPPVLER 520
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1227-1715 2.81e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 49.38  E-value: 2.81e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1227 LARELQELQEKYRVVEKQKPKVQLQE--RVSEIFQVLPETEQEIRRLRAQLQETGSKKSGVEQEVEKLLPELEVLRAQKp 1304
Cdd:COG4717     47 LLERLEKEADELFKPQGRKPELNLKElkELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLL- 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1305 vvEYKEVTQEVVRHEknpevlREIDRLKAQLNELVntngRSQEQLIRLQGERDEWKRERSKVETKMVSKevvRHEKDPVL 1384
Cdd:COG4717    126 --QLLPLYQELEALE------AELAELPERLEELE----ERLEELRELEEELEELEAELAELQEELEEL---LEQLSLAT 190

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1385 EKEAERLRQEVREAVQRRRATEDAVYELQNKLLLLERRRPEEQIVVQEVVVTQKDPKLREEHSRLSRSLDEEVGRRRQLE 1464
Cdd:COG4717    191 EEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAALLALLGLGGSLLS 270

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1465 LEVRQLGARVEEEEARLSFEEDRSKKLAAERELRQLTLKIQELEkrppALQEKIIMEEVVKLEKDPDLERStealrreld 1544
Cdd:COG4717    271 LILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALE----ELEEEELEELLAALGLPPDLSPE--------- 337

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1545 qeknRVTELHRECQGLQvqvDLLQKTKSQEKTIYKEVIRVEKDPVLE----GERARVWEILNRERAARKGREEdVRSLQE 1620
Cdd:COG4717    338 ----ELLELLDRIEELQ---ELLREAEELEEELQLEELEQEIAALLAeagvEDEEELRAALEQAEEYQELKEE-LEELEE 409

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1621 RIDRAEALRRSWSREEAELQRARdqasqdcgRLQRQLRELEQQKQQKARQLQEEGRLlsqkteSERQKAAQRSQAVTQLE 1700
Cdd:COG4717    410 QLEELLGELEELLEALDEEELEE--------ELEELEEELEELEEELEELREELAEL------EAELEQLEEDGELAELL 475

                          490
                   ....*....|....*
gi 1907079978 1701 AAILQEKDKIYEKER 1715
Cdd:COG4717    476 QELEELKAELRELAE 490
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
1387-1556 3.66e-05

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 48.70  E-value: 3.66e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1387 EAERLRQEVREAVQRRRATEDAVYELQNKLLLLERRRPEEQIVVQEVVVTQKDPKLREehsrlsrsLDEEVGRrrqLELE 1466
Cdd:COG2433    360 PPDVDRDEVKARVIRGLSIEEALEELIEKELPEEEPEAEREKEHEERELTEEEEEIRR--------LEEQVER---LEAE 428

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1467 VRQLGARVEEEEARLSFEEDRSKKLAAERElrqltlkiQELEKRppalqekiimEEVVKLEkdpdleRSTEALRRELDQE 1546
Cdd:COG2433    429 VEELEAELEEKDERIERLERELSEARSEER--------REIRKD----------REISRLD------REIERLERELEEE 484

                          170
                   ....*....|
gi 1907079978 1547 KNRVTELHRE 1556
Cdd:COG2433    485 RERIEELKRK 494
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 156-330 3.68e-05

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 47.06  E-value: 3.68e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  156 LEQKQNLVREGHYGPGMAELEQQVAEHNILQREIEAY----------GQQLRTLVGPDANTIRN-------QYRELLKAA 218
Cdd:cd00176     16 LSEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHeervealnelGEQLIEEGHPDAEEIQErleelnqRWEELRELA 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  219 SWRRQSLGSLYTHLQGCTKQLSALADQQGRILQQDWSDLMPDPAGVRREYEHFK--QHELLAQERSINQLEDDADRMVEL 296
Cdd:cd00176     96 EERRQRLEEALDLQQFFRDADDLEQWLEEKEAALASEDLGKDLESVEELLKKHKelEEELEAHEPRLKSLNELAEELLEE 175

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1907079978  297 GHPAIGP-IQVHQEALKMEWQNFLNLCICQESQLQ 330
Cdd:cd00176    176 GHPDADEeIEEKLEELNERWEELLELAEERQKKLE 210
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1226-1424 5.74e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 47.84  E-value: 5.74e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1226 ALARELQELQEKYRvvEKQKPKVQLQERVSEIFQVLPETEQEIRRLRAQLQETGSKKSGVEQEVEKLLPELEVLRAQKPV 1305
Cdd:COG4942     24 EAEAELEQLQQEIA--ELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEA 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1306 V--EYKEVTQEVVRHEKNPEVL--------------------------REIDRLKAQLNELVNTNGRSQEQLIRLQGERD 1357
Cdd:COG4942    102 QkeELAELLRALYRLGRQPPLAlllspedfldavrrlqylkylaparrEQAEELRADLAELAALRAELEAERAELEALLA 181

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907079978 1358 EWKRERSKVETKMVSKEVVRHEkdpvLEKEAERLRQEVREAVQRRRATEDAVYELQNKLLLLERRRP 1424
Cdd:COG4942    182 ELEEERAALEALKAERQKLLAR----LEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTP 244
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 932-1726 6.92e-05

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 48.04  E-value: 6.92e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  932 LRQLEFAKKML----RKKELDEDIQAIHSARQgsgsPAHARTAESEVLKTQLEEERKRVAEVQRDLEEQRQrllQLRTQQ 1007
Cdd:TIGR00618  149 LPQGEFAQFLKakskEKKELLMNLFPLDQYTQ----LALMEFAKKKSLHGKAELLTLRSQLLTLCTPCMPD---TYHERK 221

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1008 PVARLEEKEVVEFYRDPQLESNLSQAASRVEEEGKRRARLQAELEAvaqkvvhlegKRKTMQPHLLTKEVTQIERDpgLD 1087
Cdd:TIGR00618  222 QVLEKELKHLREALQQTQQSHAYLTQKREAQEEQLKKQQLLKQLRA----------RIEELRAQEAVLEETQERIN--RA 289

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1088 SQVTQLHSEMQRLRGENGVLTARLEELKDELLALEQKEMNVKEKVVVKEVVKVEKDLEMVKAAQTLRLQIE-EDAARRKG 1166
Cdd:TIGR00618  290 RKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAhEVATSIRE 369

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1167 AKETVAKIQARIKDLEQAISSVEPKVIVKEVKKVEQDPGLLKEASRLRSllEEEKNNNVALARELQELQEKYRVVEKQKP 1246
Cdd:TIGR00618  370 ISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRTSA--FRDLQGQLAHAKKQQELQQRYAELCAAAI 447

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1247 KVQLQERVSEIfqvlPETEQEIRRLRAQLQETGSKKSGVEQEVEKllpelevlraqkpvveYKEVTQEVVRHEKNPEVLR 1326
Cdd:TIGR00618  448 TCTAQCEKLEK----IHLQESAQSLKEREQQLQTKEQIHLQETRK----------------KAVVLARLLELQEEPCPLC 507

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1327 EIDRLKAQLNELVNTNGRSQEQLIRLQGERDEWKRERSKVETKMVSKEVVRHEkdpvLEKEAERLRQEVREAVQRRRATE 1406
Cdd:TIGR00618  508 GSCIHPNPARQDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRAS----LKEQMQEIQQSFSILTQCDNRSK 583

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1407 DAVYELQNKLLLLERRRPEEQIVVQEVVVTQKDPKLREEHSRlsrSLDEEVGRRRQLELEVRQLGARVEEEEARLSFEED 1486
Cdd:TIGR00618  584 EDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQ---DLQDVRLHLQQCSQELALKLTALHALQLTLTQERV 660

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1487 RsKKLAAERELRQLTLKIQELEkrPPALQEKIIMEEVVKlekdPDLERSTEALRRELDQEKnrvtELHRECQGLQVQVDL 1566
Cdd:TIGR00618  661 R-EHALSIRVLPKELLASRQLA--LQKMQSEKEQLTYWK----EMLAQCQTLLRELETHIE----EYDREFNEIENASSS 729

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1567 LQKTKSQEKTIYKEVIRvekdpvlEGERARVWEILNRERAARKGREEDVRSLQERIDRAEAlrrswsreEAELQRARDQA 1646
Cdd:TIGR00618  730 LGSDLAAREDALNQSLK-------ELMHQARTVLKARTEAHFNNNEEVTAALQTGAELSHL--------AAEIQFFNRLR 794

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1647 SQDcgrlQRQLRELEQQKQQKARQLQEEGRLLSQKTESERQKAAQRSQAVTQLEAAILQEKDKIYEKERTLRDLHTKVSR 1726
Cdd:TIGR00618  795 EED----THLLKTLEAEIGQEIPSDEDILNLQCETLVQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEQAK 870
46 PHA02562
endonuclease subunit; Provisional
 891-1118 8.64e-05

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 47.70  E-value: 8.64e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  891 PALAVSAPKRLRVIS--LQESIQAQEKNLAKAYTEVAAAEQQQL--------RQLEFAKK-MLRKKELDEDIQAIHSARQ 959
Cdd:PHA02562   143 PFMQLSAPARRKLVEdlLDISVLSEMDKLNKDKIRELNQQIQTLdmkidhiqQQIKTYNKnIEEQRKKNGENIARKQNKY 222

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  960 GSgspaHARTAESevLKTQLEEERKRVAEVQRDLEEQRQRLLQLRTQQpvARLEEK-----EVVEFYRD----PQLESNL 1030
Cdd:PHA02562   223 DE----LVEEAKT--IKAEIEELTDELLNLVMDIEDPSAALNKLNTAA--AKIKSKieqfqKVIKMYEKggvcPTCTQQI 294

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1031 SQAASRVEEEGKRRARLQAELEAVAQKVVHLEGK-----RKTMQPHLLTKEVTQIERD-PGLDSQVTQLHSEMQRLRGEN 1104
Cdd:PHA02562   295 SEGPDRITKIKDKLKELQHSLEKLDTAIDELEEImdefnEQSKKLLELKNKISTNKQSlITLVDKAKKVKAAIEELQAEF 374

                          250
                   ....*....|....
gi 1907079978 1105 GVLTARLEELKDEL 1118
Cdd:PHA02562   375 VDNAEELAKLQDEL 388
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1206-1569 9.00e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 47.45  E-value: 9.00e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1206 LLKEASRLRSLLEEEKNNNVALARELQELQEKYRVVEKQKPKVQLQERVSEIFQVLPETEQEIRRLRAQLQEtgskKSGV 1285
Cdd:COG4717     93 LQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELEALEAELAELPERLEELEERLEELRELEEE----LEEL 168

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1286 EQEVEKLLPELEVLRAQKPVVEYKEVTQEVVRHEknpEVLREIDRLKAQLNELVNTNGRSQEQLIRLQGERDEWKRERSK 1365
Cdd:COG4717    169 EAELAELQEELEELLEQLSLATEEELQDLAEELE---ELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERL 245

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1366 VETK--------MVSKEVVRHEKDPVLEKEAE------------RLRQEVREAVQRRRATEDAVYELQNKLLLLERRRPE 1425
Cdd:COG4717    246 KEARlllliaaaLLALLGLGGSLLSLILTIAGvlflvlgllallFLLLAREKASLGKEAEELQALPALEELEEEELEELL 325

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1426 EQIVVQEVVVTQKDPKLREEHSRLSRSLDEEVGRRRQLELEVRQLGARVEEEEARLSFEEDRSKKLAAERELRQLTLKIQ 1505
Cdd:COG4717    326 AALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALLAEAGVEDEEELRAALEQAEEYQELKEELE 405

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907079978 1506 ELEKRPPALQEKiiMEEVVKLEKDPDLERSTEALRRELDQEKNRVTELHRECQGLQVQVDLLQK 1569
Cdd:COG4717    406 ELEEQLEELLGE--LEELLEALDEEELEEELEELEEELEELEEELEELREELAELEAELEQLEE 467
SPEC smart00150
Spectrin repeats;
256-330 1.33e-04

Spectrin repeats;


Pssm-ID: 197544 [Multi-domain]  Cd Length: 101  Bit Score: 43.09  E-value: 1.33e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907079978   256 DLMPDPAGVRREYEHFK--QHELLAQERSINQLEDDADRMVELGHPAIGPIQVHQEALKMEWQNFLNLCICQESQLQ 330
Cdd:smart00150   25 DLGKDLESVEALLKKHEafEAELEAHEERVEALNELGEQLIEEGHPDAEEIEERLEELNERWEELKELAEERRQKLE 101
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1531-1720 1.51e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 46.93  E-value: 1.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1531 DLERSTEALRRELDQEKNRVTELHRECQGLQVQVDLLQkTKSQEKTIYKEVIRVEKDpvLEGERARVWEILNRERAARKG 1610
Cdd:COG3206    172 EARKALEFLEEQLPELRKELEEAEAALEEFRQKNGLVD-LSEEAKLLLQQLSELESQ--LAEARAELAEAEARLAALRAQ 248

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1611 REEDVRSLQERIdrAEALRRSWSREEAELQRARDQASQDCGRLQRQLRELEQQKQQKARQLQEEGRLLSQKTESERQKAA 1690
Cdd:COG3206    249 LGSGPDALPELL--QSPVIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQLQQEAQRILASLEAELEALQ 326

                          170       180       190
                   ....*....|....*....|....*....|
gi 1907079978 1691 QRSQAVTQLEAAILQEKDKIYEKERTLRDL 1720
Cdd:COG3206    327 AREASLQAQLAQLEARLAELPELEAELRRL 356
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 906-1494 1.57e-04

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 46.89  E-value: 1.57e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  906 LQESIQAQEKNLAKAYTEVAAAEQQQLRQLEFAKKMLRKKELDEDIQAIHSARQG----------------------SGS 963
Cdd:TIGR00618  231 LREALQQTQQSHAYLTQKREAQEEQLKKQQLLKQLRARIEELRAQEAVLEETQERinrarkaaplaahikavtqieqQAQ 310

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  964 PAHARTAESEVLKTQLEEERKRVAEVQRDLEEQRQRLLQLRTQ---------QPVARLEEKEVVEFYRDP---------- 1024
Cdd:TIGR00618  311 RIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQeihirdaheVATSIREISCQQHTLTQHihtlqqqktt 390

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1025 --QLESNLSQAASRVEEEGKRRARLQAELEAVAQKVVHLEGKRKTMQPHLLTKEV-------TQIERDPGLDSQVTQLHS 1095
Cdd:TIGR00618  391 ltQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAaitctaqCEKLEKIHLQESAQSLKE 470

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1096 EMQRLrGENGVLTARLEELKDELLA--LEQKEMNVKEKVVVKEVVKVEKDLEMVKAAQTLRLQIEEDAARRKGAKETV-- 1171
Cdd:TIGR00618  471 REQQL-QTKEQIHLQETRKKAVVLArlLELQEEPCPLCGSCIHPNPARQDIDNPGPLTRRMQRGEQTYAQLETSEEDVyh 549

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1172 -----AKIQARIKDLEQAISSVEPKVIVKEVKKVEQDPGLLKEASRLRSLLEEEKNNNVALARELQELQEKYRVVEKQKP 1246
Cdd:TIGR00618  550 qltseRKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQD 629

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1247 KVQLQERVSEIFQV-----------LPETEQEIRRLRAQLQETGSKKSgVEQEVEKLLPELEVLRAQKPVVEYKevtQEV 1315
Cdd:TIGR00618  630 VRLHLQQCSQELALkltalhalqltLTQERVREHALSIRVLPKELLAS-RQLALQKMQSEKEQLTYWKEMLAQC---QTL 705

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1316 VRHEKnpEVLREIDRLKAQLNELVNTNGRS-QEQLIRLQGERDEWKRERSKVETKMVSKEVVRHEKDPVLEKEAERLRQE 1394
Cdd:TIGR00618  706 LRELE--THIEEYDREFNEIENASSSLGSDlAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQTGAELSHL 783

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1395 VREAVQRRRATEDAVYELQNKLLLLERRRPEEQIVVQEVVVTQK------DPKLREEHSRLS--RSLDEEVGRRRQLELE 1466
Cdd:TIGR00618  784 AAEIQFFNRLREEDTHLLKTLEAEIGQEIPSDEDILNLQCETLVqeeeqfLSRLEEKSATLGeiTHQLLKYEECSKQLAQ 863

                          650       660       670
                   ....*....|....*....|....*....|....*.
gi 1907079978 1467 VRQLGARVEEEEARL--------SFEEDRSKKLAAE 1494
Cdd:TIGR00618  864 LTQEQAKIIQLSDKLnginqikiQFDGDALIKFLHE 899
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1459-1670 1.87e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 46.30  E-value: 1.87e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1459 RRRQLELEVRQLGARVEEEEARLsfEEDRSKKLAAERELRQLTLKIQELEKRPPALQEKIIMEEvvklEKDPDLERSTEA 1538
Cdd:COG4942     21 AAAEAEAELEQLQQEIAELEKEL--AALKKEEKALLKQLAALERRIAALARRIRALEQELAALE----AELAELEKEIAE 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1539 LRRELDQEKNRVTELHRECQ--GLQVQVDLLQKTKSQEKTI-----YKEVIRVEKDPV---------LEGERARVWEILN 1602
Cdd:COG4942     95 LRAELEAQKEELAELLRALYrlGRQPPLALLLSPEDFLDAVrrlqyLKYLAPARREQAeelradlaeLAALRAELEAERA 174

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907079978 1603 RERAARKGREEDVRSLQERIDRAEALRRSWSREEAELQRARDQASQDCGRLQRQLRELEQQKQQKARQ 1670
Cdd:COG4942    175 ELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAER 242
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 686-1327 1.94e-04

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 46.64  E-value: 1.94e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  686 EKAKAALGLEKQIQEADRVIQGFEAALALEGPVPEGSGALQERVSELQRQRKEL----------------------LQQQ 743
Cdd:pfam05483  128 ENEKVSLKLEEEIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETrqvymdlnnniekmilafeelrVQAE 207

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  744 ACVLGLHRQLKATEHACSALQnnfQEFCQDLPRQQRQVRAL----TDRYHAVGDQLDLREKIVQDASLTYQQLRNSRDNL 819
Cdd:pfam05483  208 NARLEMHFKLKEDHEKIQHLE---EEYKKEINDKEKQVSLLliqiTEKENKMKDLTFLLEESRDKANQLEEKTKLQDENL 284

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  820 SSWLEQLPHHRVQPSDGPSQISYKLQAQKRLIQEIlgrEQDQATVSRLTRDLQEALQDY------------ELQADTyrC 887
Cdd:pfam05483  285 KELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDL---QIATKTICQLTEEKEAQMEELnkakaahsfvvtEFEATT--C 359

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  888 SLEPALAVSAPK------RLRVISLQESIQAQEKNLAKAYTEVAAAEQQQLR-------QLEFAKKMLRK--KELDEDIQ 952
Cdd:pfam05483  360 SLEELLRTEQQRleknedQLKIITMELQKKSSELEEMTKFKNNKEVELEELKkilaedeKLLDEKKQFEKiaEELKGKEQ 439

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  953 AIHSARQGSGSPAHARTAESEVLKTQLEEERKRVAEVQRDLEEQRQRLLQLRTQQPVARLEEKEVVEFYRDPQLEsnLSQ 1032
Cdd:pfam05483  440 ELIFLLQAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLLENKELTQEASDMTLE--LKK 517

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1033 AASRVEEEGKRRARLQAELEAVAQKVVHLEGKRKTMQPHLLTKEVTQIERDPGLDSQVTQLHSEMQRLRGENGVLTARLE 1112
Cdd:pfam05483  518 HQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCN 597

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1113 ELKDEllaLEQKEMNVKekvvvkevvkvekdlemvkaaqtlRLQIEEDAARRKGAKET---------VAKIQARIKDLEQ 1183
Cdd:pfam05483  598 NLKKQ---IENKNKNIE------------------------ELHQENKALKKKGSAENkqlnayeikVNKLELELASAKQ 650

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1184 AISSVEPKVIVKEVKKVEQDPGLLKEASRLRSLLEEEknnnVALARELqELQEKYRVVEkqkpKVQLQERVSEIF-QVLP 1262
Cdd:pfam05483  651 KFEEIIDNYQKEIEDKKISEEKLLEEVEKAKAIADEA----VKLQKEI-DKRCQHKIAE----MVALMEKHKHQYdKIIE 721

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907079978 1263 ETEQEIRRLRAQLQETGSKKSGVEQEVEKLLPELEVLRAQKPvVEYKEVTQEVVRHEKNPEVLRE 1327
Cdd:pfam05483  722 ERDSELGLYKNKEQEQSSAKAALEIELSNIKAELLSLKKQLE-IEKEEKEKLKMEAKENTAILKD 785
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
 727-1118 2.13e-04

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 46.72  E-value: 2.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  727 ERVSELQRQRKELLQQQACVLGLHRQLKATEHACSALQ-----NNFQEFCQDLPRQQRQVRALTDRYHAVgdqLDLREKI 801
Cdd:PRK10246   254 ELQQEASRRQQALQQALAAEEKAQPQLAALSLAQPARQlrphwERIQEQSAALAHTRQQIEEVNTRLQST---MALRARI 330

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  802 VQDASLTYQQLRNSRDNLSSWLEQLPHHRVQPSDGP------SQISYKLQAQKRLIQEILGREQDQATVSRLTRDL--QE 873
Cdd:PRK10246   331 RHHAAKQSAELQAQQQSLNTWLAEHDRFRQWNNELAgwraqfSQQTSDREQLRQWQQQLTHAEQKLNALPAITLTLtaDE 410

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  874 ALQDYELQADtyrcslepalavSAPKRLRVISLQESIQAQEKNLAKAYTEVAAAEQQQLRqlefAKKMLRKKELDEDIQA 953
Cdd:PRK10246   411 VAAALAQHAE------------QRPLRQRLVALHGQIVPQQKRLAQLQVAIQNVTQEQTQ----RNAALNEMRQRYKEKT 474

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  954 IHSARqgsgspahartaesevLKTQLEEErkrvaEVQRDLEEQRQRlLQLRTQQPVARLEEKEVVEFYRdpQLESNLSQA 1033
Cdd:PRK10246   475 QQLAD----------------VKTICEQE-----ARIKDLEAQRAQ-LQAGQPCPLCGSTSHPAVEAYQ--ALEPGVNQS 530

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1034 asrveeegkRRARLQAELEAVAQKVVHLEGKRKTMQphlltkevTQIERDpgldsqvtqlHSEMQRLRGENGVLTARLEE 1113
Cdd:PRK10246   531 ---------RLDALEKEVKKLGEEGAALRGQLDALT--------KQLQRD----------ESEAQSLRQEEQALTQQWQA 583


                   ....*
gi 1907079978 1114 LKDEL 1118
Cdd:PRK10246   584 VCASL 588
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 582-1081 3.03e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 46.08  E-value: 3.03e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  582 QTLLSQMTQLDGDLGQIERQVLSWARSPLSQSSSLKDLEGRIHSCEGTAQRLQSLGAEKEAAQQECEAFLSTKpTGSAAL 661
Cdd:COG1196    319 EELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEA-LRAAAE 397

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  662 QLPVVLNSVKNRYNDVQSLCHLYGEKAKAALGLEKQIQEADRVIQGFEAALALEGPVPEGSGALQERVSELQRQRKELLQ 741
Cdd:COG1196    398 LAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEA 477

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  742 QQACVLGLHRQLKATEHACSALQNNFQEFCQD-LPRQQRQVRALTDRYHAVGDQLDLREKIVQDASLTYQQLRNSRDNLS 820
Cdd:COG1196    478 ALAELLEELAEAAARLLLLLEAEADYEGFLEGvKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDE 557

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  821 S------WLEQLPHHRVQ----PSDGPSQISYKLQAQKRLIQEILGREQDQATVSRLTRDLQEALQDYELQADTYRCSLE 890
Cdd:COG1196    558 VaaaaieYLKAAKAGRATflplDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALR 637

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  891 PALAVSAPKRLRVISLQESIQAQEKNLAKAYTEVAAAEQQQLRQLEFAKKMLRKKELDEDIQAIHSARQgsgspahartA 970
Cdd:COG1196    638 RAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEE----------R 707

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  971 ESEVLKTQLEEERKRVAEVQRDLEEQRQRLLQLRTQQPVARLEEKEVvefyrDPQLESNLSQAASRVEEEGKRRARLQA- 1049
Cdd:COG1196    708 ELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALE-----ELPEPPDLEELERELERLEREIEALGPv 782

                          490       500       510
                   ....*....|....*....|....*....|....*...
gi 1907079978 1050 ------ELEAVAQKVVHLEGKRKTmqphlLTKEVTQIE 1081
Cdd:COG1196    783 nllaieEYEELEERYDFLSEQRED-----LEEARETLE 815
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 1352-1707 3.65e-04

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 45.27  E-value: 3.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1352 LQGERDEWKRERSKVETKMVSKEVVRHEKDPVLEKEAERLRQEVREAVQRRRATEDAVYELQNKLLLLERRRPEEQIVVQ 1431
Cdd:pfam07888   32 LQNRLEECLQERAELLQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSASSE 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1432 EvvvtqkdpkLREEHSRLSRSLDEEVGRRRQLELEVRQLGARVEEEEARLSFEEDRSKKLAAERelrqltlKIQELEKRp 1511
Cdd:pfam07888  112 E---------LSEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQR-------KEEEAERK- 174

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1512 pALQEKiimeevvklekdpdLERSTEALRR---ELDQEKNRVTELHRECQGLQVQVDLLQKTKSQEktiykevirvekdp 1588
Cdd:pfam07888  175 -QLQAK--------------LQQTEEELRSlskEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTA-------------- 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1589 vlegerarvweilNRERAARKGREEDVRSLQERID----RAEALRRSWS-------REEAELQRARDQASQdcgrLQRQL 1657
Cdd:pfam07888  226 -------------HRKEAENEALLEELRSLQERLNaserKVEGLGEELSsmaaqrdRTQAELHQARLQAAQ----LTLQL 288

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1658 RELEQQKQQKARQLQEEGRLLSQKTESERQKAAQRSQAVTQLEAAILQEK 1707
Cdd:pfam07888  289 ADASLALREGRARWAQERETLQQSAEADKDRIEKLSAELQRLEERLQEER 338
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 845-1057 3.84e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 45.14  E-value: 3.84e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  845 QAQKRLIQEILGREQDQATVSRLTRDLQEALQDYELQADTYRCSLEPALAVSAPKRLRVISLQESIQAQEKNLAKAYTEV 924
Cdd:COG4942     27 AELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEEL 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  925 AA--AEQQQLRQLEFAKKMLRKKELDEDI------QAIHSARQGSGSPAHARTAESEVLKTQLEEERKRVAEVQRDLEEQ 996
Cdd:COG4942    107 AEllRALYRLGRQPPLALLLSPEDFLDAVrrlqylKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEE 186

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907079978  997 RQRLLQLRTQQpvarleeKEVVEfyrdpQLESNLSQAASRVEEEGKRRARLQAELEAVAQK 1057
Cdd:COG4942    187 RAALEALKAER-------QKLLA-----RLEKELAELAAELAELQQEAEELEALIARLEAE 235
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 923-1574 4.05e-04

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 45.49  E-value: 4.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  923 EVAAAEQQQLRQLEFAKKMLRKKEL--DEDIQAIHSARQGSGSPAHARTAESEVLKTQlEEERKRVAEVQRDLEEQRQRL 1000
Cdd:pfam15921  248 EALKSESQNKIELLLQQHQDRIEQLisEHEVEITGLTEKASSARSQANSIQSQLEIIQ-EQARNQNSMYMRQLSDLESTV 326

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1001 LQLRTqqpvarlEEKEVVEFYRDP--QLESNLSQAASRVEEEGKRRARLQAE---LEAVAQKVV-HLEGKRKTMQphlLT 1074
Cdd:pfam15921  327 SQLRS-------ELREAKRMYEDKieELEKQLVLANSELTEARTERDQFSQEsgnLDDQLQKLLaDLHKREKELS---LE 396

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1075 KEVTQ--IERDPGLDSQVTQLHSEMQRLRGENGVLTARLEELKDELLALEQKEMNVKEKVVVKEVVKVEKDLEMVKAAQT 1152
Cdd:pfam15921  397 KEQNKrlWDRDTGNSITIDHLRRELDDRNMEVQRLEALLKAMKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEM 476

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1153 LRLQIEEDAARR---KGAKETVAKIQARIKDLEQAISSVEPKVIVKEVKKVEQdpglLKEASRLRSllEEEKNNNVALAR 1229
Cdd:pfam15921  477 LRKVVEELTAKKmtlESSERTVSDLTASLQEKERAIEATNAEITKLRSRVDLK----LQELQHLKN--EGDHLRNVQTEC 550

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1230 ELQELQ--EKYRVVE----------------------KQKPKVQLQERVSEI------FQVLPET-EQEIRRLRAQLQE- 1277
Cdd:pfam15921  551 EALKLQmaEKDKVIEilrqqienmtqlvgqhgrtagaMQVEKAQLEKEINDRrlelqeFKILKDKkDAKIRELEARVSDl 630

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1278 ---------TGSKK----SGVEQEVEKLLPELEVLRAQ-KPVVEYKEVTQEVVRHeKNPEVLREIDRLKAQL-------- 1335
Cdd:pfam15921  631 elekvklvnAGSERlravKDIKQERDQLLNEVKTSRNElNSLSEDYEVLKRNFRN-KSEEMETTTNKLKMQLksaqsele 709

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1336 ---NELVNTNGRS----------QEQLIRLQGERDEWKRERSKVETKMVSKEVVRHekdpVLEKEAERLRQEVREAvqrr 1402
Cdd:pfam15921  710 qtrNTLKSMEGSDghamkvamgmQKQITAKRGQIDALQSKIQFLEEAMTNANKEKH----FLKEEKNKLSQELSTV---- 781

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1403 rATEDAVYELQNKLLLLERRRPEEQIVVQEVVVTQKDPKLREEHSRLSRSLDEEVGRRRQLELEVRQLG----------- 1471
Cdd:pfam15921  782 -ATEKNKMAGELEVLRSQERRLKEKVANMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTLDVKELQgpgytsnssmk 860

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1472 -------------ARVEEEEARLSFEEDRSKKLAAERE--LRQLTLKIQELekRPPalqekIIMEEVVKLEKDPDLERST 1536
Cdd:pfam15921  861 prllqpasftrthSNVPSSQSTASFLSHHSRKTNALKEdpTRDLKQLLQEL--RSV-----INEEPTVQLSKAEDKGRAP 933

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*
gi 1907079978 1537 EALRRElDQEKNRVTEL-------HRECQGLQVQVDLLQKTKSQE 1574
Cdd:pfam15921  934 SLGALD-DRVRDCIIESslrsdicHSSSNSLQTEGSKSSETCSRE 977
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 907-1287 4.83e-04

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 45.35  E-value: 4.83e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  907 QESIQAQEKNLAKAYtEVAAAEQQQLRQLEFAKKMLRKKELDEDIQAIHSARQGSGSPAHARTAESEVLKTQLEEERKRV 986
Cdd:pfam02463  679 QELQEKAESELAKEE-ILRRQLEIKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRL 757

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  987 aEVQRDLEEQRQRLLQLRTQQPVARLEEKEVVEfyrdpQLESNLSQAASRVEEEGKRRARLQAELEAVAQKVVHLEGKRK 1066
Cdd:pfam02463  758 -KKEEKEEEKSELSLKEKELAEEREKTEKLKVE-----EEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIK 831

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1067 TMQPHLLTKEVTQIERDPGLDSQVTQLHSEMQRLRGENGVLTARLEELKDELLALEQKEMNVKEKVVVKEVVKVekdlem 1146
Cdd:pfam02463  832 EEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEE------ 905

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1147 vkaaqTLRLQIEEDAARRKGAKETVAKIQARIKDLEQAISSVEPKVIVKEVKKVEQDPGLLKEASRLRSLLEEEKNNNVA 1226
Cdd:pfam02463  906 -----SQKLNLLEEKENEIEERIKEEAEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAI 980

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907079978 1227 LarELQELQEKYRVVEKQKPKVQlQERVSEIFQVLPETEQEIRRLRAQLQETGSKKSGVEQ 1287
Cdd:pfam02463  981 E--EFEEKEERYNKDELEKERLE-EEKKKLIRAIIEETCQRLKEFLELFVSINKGWNKVFF 1038
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
851-1125 4.87e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 45.39  E-value: 4.87e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  851 IQEILGREQDQATVSRLtrDLQEALQDYELQADTYRCSLEPALAVSAPKRLRVISLqeSIQAQEKNLAK----AYTEVAA 926
Cdd:COG3206     87 IEILKSRPVLERVVDKL--NLDEDPLGEEASREAAIERLRKNLTVEPVKGSNVIEI--SYTSPDPELAAavanALAEAYL 162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  927 AEQQQLRQ------LEFAKKMLR--KKELDEDIQAIHSARQGSGSPAHARTAESEVlkTQLEEERKRVAEVQRDLEEQRQ 998
Cdd:COG3206    163 EQNLELRReearkaLEFLEEQLPelRKELEEAEAALEEFRQKNGLVDLSEEAKLLL--QQLSELESQLAEARAELAEAEA 240

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  999 RLLQLRTQQPVARLEEKEVVEFYRDPQLESNLSQAASrveeegkRRARLQAELEAVAQKVVHLEGKRKTMQPhLLTKEVT 1078
Cdd:COG3206    241 RLAALRAQLGSGPDALPELLQSPVIQQLRAQLAELEA-------ELAELSARYTPNHPDVIALRAQIAALRA-QLQQEAQ 312

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 1907079978 1079 QIerdpgldsqVTQLHSEMQRLRGENGVLTARLEELKDELLALEQKE 1125
Cdd:COG3206    313 RI---------LASLEAELEALQAREASLQAQLAQLEARLAELPELE 350
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 928-1281 5.09e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 45.11  E-value: 5.09e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  928 EQQQLRQL--EFAKKMLRKKELDEDiqaiHSARQGSGSPAHARTAESEvlktQLEEERKRvaEVQRDLEEQRQRLLQLRT 1005
Cdd:pfam17380  297 EQERLRQEkeEKAREVERRRKLEEA----EKARQAEMDRQAAIYAEQE----RMAMERER--ELERIRQEERKRELERIR 366

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1006 QQPVArleekevVEFYRDPQLEsnlsqaasRVEEEGKRR-ARLQAELEAVAQKVVHLEGKRKTMQPHLLTKEVTQIERDP 1084
Cdd:pfam17380  367 QEEIA-------MEISRMRELE--------RLQMERQQKnERVRQELEAARKVKILEEERQRKIQQQKVEMEQIRAEQEE 431

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1085 GLDSQVTQLHSE----MQRLRGENGVLTARLEELKDELLALEQKEMNVKEKVVVKEVVKVEKDLEMVKAAQTLRLQIEED 1160
Cdd:pfam17380  432 ARQREVRRLEEErareMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEE 511

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1161 AARRKGAKETVAKIQARIKDLEQaissvepkvivkevkkveqdpgllkeasrlRSLLEEEKNNNVALaRELQELQEKYRV 1240
Cdd:pfam17380  512 ERKRKLLEKEMEERQKAIYEEER------------------------------RREAEEERRKQQEM-EERRRIQEQMRK 560

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 1907079978 1241 VEKQKPKVQLQERVSEIFQVLPETEQEIRRLRAQLQETGSK 1281
Cdd:pfam17380  561 ATEERSRLEAMEREREMMRQIVESEKARAEYEATTPITTIK 601
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 1148-1537 5.14e-04

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 44.95  E-value: 5.14e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1148 KAAQTLRLQIEEDAARRKGAKETVAKIQARIKDLEQAISSVEPKVIVKEVKKVEQDPGLLKEASRLRSLLEEEKNNNVAL 1227
Cdd:COG5185    208 KESETGNLGSESTLLEKAKEIINIEEALKGFQDPESELEDLAQTSDKLEKLVEQNTDLRLEKLGENAESSKRLNENANNL 287

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1228 ARELQELQEKYRVVEKQKPKVQLQERVSEIFQVLPETEQEIRRLRAQLQETGSKKSGVEQEVEKLLPELEVLRAQKpvve 1307
Cdd:COG5185    288 IKQFENTKEKIAEYTKSIDIKKATESLEEQLAAAEAEQELEESKRETETGIQNLTAEIEQGQESLTENLEAIKEEI---- 363

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1308 ykevtQEVVRHEKNPEVLREIDRLKAQLNELVntngrsqeqlirlqgERDEWKRERSKVETKMVSKEVVRHEKdpVLEKE 1387
Cdd:COG5185    364 -----ENIVGEVELSKSSEELDSFKDTIESTK---------------ESLDEIPQNQRGYAQEILATLEDTLK--AADRQ 421

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1388 AERLRQEVREAVQRrratedaVYELQNKLLLLERRRPEEQIVVQEVVVTQKDPKLREEHSRLSRSLDEEVGRRRQLELEV 1467
Cdd:COG5185    422 IEELQRQIEQATSS-------NEEVSKLLNELISELNKVMREADEESQSRLEEAYDEINRSVRSKKEDLNEELTQIESRV 494

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907079978 1468 RQLGARVEEEEARLsfeedrSKKLAAER-ELRQLTLKIQELEKRPPALQEKIIMEEVVKLEKDPDLERSTE 1537
Cdd:COG5185    495 STLKATLEKLRAKL------ERQLEGVRsKLDQVAESLKDFMRARGYAHILALENLIPASELIQASNAKTD 559
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 1746-1774 5.48e-04

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 39.23  E-value: 5.48e-04
                           10        20
                   ....*....|....*....|....*....
gi 1907079978 1746 ILEPETGNDMSPYEAYKRGVIDRGQYLQL 1774
Cdd:pfam00681   11 IIDPVTGERLSVEEAVKRGLIDPETAQKL 39
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 905-1123 6.02e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 44.37  E-value: 6.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  905 SLQESIQAQEKNLAKAYTEVAAAeQQQLRQLEfakkmlrkKELDEDIQAIHSARQgsgspahartaESEVLKTQLEEERK 984
Cdd:COG4942     31 QLQQEIAELEKELAALKKEEKAL-LKQLAALE--------RRIAALARRIRALEQ-----------ELAALEAELAELEK 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  985 RVAEVQRDLEEQRQRL-LQLRTQQPVARLEEKEVVEFYRDPQLESNLSQAASRVEEEGKRRAR-LQAELEAVAQKVVHLE 1062
Cdd:COG4942     91 EIAELRAELEAQKEELaELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEeLRADLAELAALRAELE 170

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907079978 1063 GKRKTMQpHLLTKEVTQIERdpgLDSQVTQLHSEMQRLRGENGVLTARLEELKDELLALEQ 1123
Cdd:COG4942    171 AERAELE-ALLAELEEERAA---LEALKAERQKLLARLEKELAELAAELAELQQEAEELEA 227
CHASE3 COG5278
Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms];
1325-1741 8.55e-04

Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms];


Pssm-ID: 444089 [Multi-domain]  Cd Length: 530  Bit Score: 44.13  E-value: 8.55e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1325 LREIDRLKAQLNELVNTNGRSQEQLIRLQGERDEWKRERSKVeTKMVSKEVVRHEKDPVLEKEAERLRQEVREAVQRRRA 1404
Cdd:COG5278     85 RAEIDELLAELRSLTADNPEQQARLDELEALIDQWLAELEQV-IALRRAGGLEAALALVRSGEGKALMDEIRARLLLLAL 163

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1405 TEDAVYELQNKLLLLERRRPEEQIVVQEVVVTQKDPKLREEHSRLSRSLDEEVGRRRQLELEVRQLGARVEEEEARLSFE 1484
Cdd:COG5278    164 ALAALLLAAAALLLLLLALAALLALAELLLLALARALAALLLLLLLEAELAAAAALLAAAAALAALAALELLAALALALA 243

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1485 EDRSKKLAAERELRQLTLKIQELEKRPPALQEKIIMEEVVKLEKDPDLERSTEALRRELDQEKNRVTELHRECQGLQVQV 1564
Cdd:COG5278    244 LLLAALLLALLAALALAALLAAALLALAALLLALAAAAALAAAAALELAAAEALALAELELELLLAAAAAAAAAAAAAAA 323

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1565 DLLQKTKSQEKTIYKEVIRVEKDPVLEGERARvwEILNRERAARKGREEDVRSLQERIDRAEALRRSWSREEAELQRARD 1644
Cdd:COG5278    324 ALAALLALALATALAAAAAALALLAALLAEAA--AAAAEEAEAAAEAAAAALAGLAEVEAEGAAEAVELEVLAIAAAAAA 401

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1645 QASQDCGRLQRQLRELEQQKQQKARQLQEEGRLLSQKTESERQKAAQRSQAVTQLEAAILQEKDKIYEKERTLRDLHTKV 1724
Cdd:COG5278    402 AAAEAAAAAAAAAAASAAEALELAEALAEALALAEEEALALAAASSELAEAGAALALAAAEALAEELAAVAALAALAAAA 481

                          410
                   ....*....|....*..
gi 1907079978 1725 SREELNQETQTRETNLS 1741
Cdd:COG5278    482 AALAEAEAAAALAAAAA 498
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1441-1637 9.20e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.98  E-value: 9.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1441 KLREEHSRLSRSLDEEVGRRRQLELEVRQLGARVEEEEARLSFEEDRSKKLaaERELRQLTLKIQELEKRPPALQEKII- 1519
Cdd:COG4942     31 QLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAAL--EAELAELEKEIAELRAELEAQKEELAe 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1520 -------------MEEVVKLEKDPDLERSTEALRRELDQEKNRVTELHRECQGLQVQVDLLQKTKSQEKTIYKEVIRVEK 1586
Cdd:COG4942    109 llralyrlgrqppLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEERA 188

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907079978 1587 D-PVLEGERARVWEILNRERAARKGR----EEDVRSLQERIDRAEALRRSWSREEA 1637
Cdd:COG4942    189 AlEALKAERQKLLARLEKELAELAAElaelQQEAEELEALIARLEAEAAAAAERTP 244
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1493-1702 9.23e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.05  E-value: 9.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1493 AERELRQLTLKIQELEKRPPALQEKIImeevvklekdpDLERSTEALRRELDQEKNRVTELHRECQGLQVQVDLLQKTKS 1572
Cdd:COG3883     14 ADPQIQAKQKELSELQAELEAAQAELD-----------ALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIE 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1573 QEKTIYKEVIRVEK---------DPVLEGE-------RARVW--------EILNRERAARKGREEDVRSLQERIDRAEAL 1628
Cdd:COG3883     83 ERREELGERARALYrsggsvsylDVLLGSEsfsdfldRLSALskiadadaDLLEELKADKAELEAKKAELEAKLAELEAL 162

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907079978 1629 RRSWSREEAELQRARDQASQDCGRLQRQLRELEQQKQQKARQLQEEGRLLSQKTESERQKAAQRSQAVTQLEAA 1702
Cdd:COG3883    163 KAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAA 236
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 582-1126 1.07e-03

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 44.19  E-value: 1.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  582 QTLLSQMTQLDGDLGQIERQVLSWARSPLSQSSSLKDLEGRIHSCEGTAQRLQSLGAEKEAAQQEceAFLSTKPTGSAAL 661
Cdd:TIGR00618  385 QQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITC--TAQCEKLEKIHLQ 462

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  662 QLPVVLNSVKNRYNDVQSLCHLYGEKAKAALGLEKQIQEADRVIQGFEAALALEGPVPEGSGALQERVSELQRQRKELLQ 741
Cdd:TIGR00618  463 ESAQSLKEREQQLQTKEQIHLQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDNPGPLTRRMQRGEQTYAQLET 542

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  742 QqacvlglhrqLKATEHACSALQNNFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLREKIVQDasltyqqlrnsrdnLSS 821
Cdd:TIGR00618  543 S----------EEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVR--------------LQD 598

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  822 WLEQLPHHRVQpsdgpsqisyklqaqKRLIQEILGREqdqatvsrltrdLQEALQDYELQADTYRCSLEPALAVSAPKRL 901
Cdd:TIGR00618  599 LTEKLSEAEDM---------------LACEQHALLRK------------LQPEQDLQDVRLHLQQCSQELALKLTALHAL 651

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  902 RVISLQE-------SIQAQEKNLAKAYTEVAAAEQQQLRQLEFAKKMLRKKelDEDIQAIHSARQGSGSPAHARTAESEV 974
Cdd:TIGR00618  652 QLTLTQErvrehalSIRVLPKELLASRQLALQKMQSEKEQLTYWKEMLAQC--QTLLRELETHIEEYDREFNEIENASSS 729

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  975 LKTQLEEERKRVAEVQRDLEEQRQRLLQLRTQQPvARLEEKEVVEFYRDPQLESNLSQAASRVEEEGKRRARLQAELEAV 1054
Cdd:TIGR00618  730 LGSDLAAREDALNQSLKELMHQARTVLKARTEAH-FNNNEEVTAALQTGAELSHLAAEIQFFNRLREEDTHLLKTLEAEI 808

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907079978 1055 AQKVVHLEGKRkTMQPHLLTKEVTQierdpgLDSQVTQLHSEMQRLRGENGVLTARLEELkdELLALEQKEM 1126
Cdd:TIGR00618  809 GQEIPSDEDIL-NLQCETLVQEEEQ------FLSRLEEKSATLGEITHQLLKYEECSKQL--AQLTQEQAKI 871
PLEC smart00250
Plectin repeat;
1878-1913 1.17e-03

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 38.23  E-value: 1.17e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1907079978  1878 LTEDSFPIAGIYDTTTDNKCSIKAAVAKNMLDPITG 1913
Cdd:smart00250    3 LLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 975-1397 1.19e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 43.86  E-value: 1.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  975 LKTQLEEERKRVAEVQRDLEEQRQRLLQLRTQqpVARLEeKEVVEfyrdpqLESNLSQAASRVEEEGKRRARLQAELEAV 1054
Cdd:TIGR04523  312 LKSELKNQEKKLEEIQNQISQNNKIISQLNEQ--ISQLK-KELTN------SESENSEKQRELEEKQNEIEKLKKENQSY 382

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1055 AQKVVHLEGKRKTMQPHLLTKEVTQIERD---PGLDSQVTQLHSEMQRLRGENGVLTARLEELKDELLALEQKEMNVKEK 1131
Cdd:TIGR04523  383 KQEIKNLESQINDLESKIQNQEKLNQQKDeqiKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNT 462

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1132 VVVKEVVKVEKDLEMVKAAQTLRL---QIEEDAARRKGAKETVAKIQARIKDLEQAISSVEPKVIVKEVKKVEQDPGLLK 1208
Cdd:TIGR04523  463 RESLETQLKVLSRSINKIKQNLEQkqkELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISD 542

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1209 EASRLRSLLEEEKNNNvaLARELQELQEKyrVVEKQKPKVQLQERVSEIFQVLPETEQEIRRLRAQLQETGSKKSGVEQE 1288
Cdd:TIGR04523  543 LEDELNKDDFELKKEN--LEKEIDEKNKE--IEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKE 618

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1289 VEKLLPELEVLRAQKPVVEY-KEVTQEVVRHEKNPevlreIDRLKAQLNELVNTNGRSQEQLIRLQGERDEWKRERSKVE 1367
Cdd:TIGR04523  619 LEKAKKENEKLSSIIKNIKSkKNKLKQEVKQIKET-----IKEIRNKWPEIIKKIKESKTKIDDIIELMKDWLKELSLHY 693

                          410       420       430
                   ....*....|....*....|....*....|
gi 1907079978 1368 TKMVsKEVVRHEKDPVLEKEAERLRQEVRE 1397
Cdd:TIGR04523  694 KKYI-TRMIRIKDLPKLEEKYKEIEKELKK 722
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 1353-1721 1.30e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 44.17  E-value: 1.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1353 QGERDEWKRERSKVeTKMVSKEVVRH--EKDPVLEKEAErLRQEVREAVQRRRATEDAVYELQNKLLLLERRRpeeqivv 1430
Cdd:COG3096    252 QSDRDLFKHLITEA-TNYVAADYMRHanERRELSERALE-LRRELFGARRQLAEEQYRLVEMARELEELSARE------- 322

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1431 qevVVTQKDPKLREEHSRLSRS---LDEEVGRRRQlelEVRQLGARVEE-----EEARLSFEEDRSKKLAAERELRQLTL 1502
Cdd:COG3096    323 ---SDLEQDYQAASDHLNLVQTalrQQEKIERYQE---DLEELTERLEEqeevvEEAAEQLAEAEARLEAAEEEVDSLKS 396

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1503 KIQELEKRPPALQEKII--------MEEVVKLEKDPDLerSTEALRRELDQEKNRVTELHRECQGLQVQVDLLQKTKSQE 1574
Cdd:COG3096    397 QLADYQQALDVQQTRAIqyqqavqaLEKARALCGLPDL--TPENAEDYLAAFRAKEQQATEEVLELEQKLSVADAARRQF 474

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1575 KTIY-------------------KEVIR--------VEKDPVLEGERARVWEILNRERAARKGREEDVRSLQERIDRAEA 1627
Cdd:COG3096    475 EKAYelvckiageversqawqtaRELLRryrsqqalAQRLQQLRAQLAELEQRLRQQQNAERLLEEFCQRIGQQLDAAEE 554

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1628 LRRSWSREEAELQRARDQAS---QDCGRLQRQLRELEQQK-------------QQKARQLQEE-GRLL--SQKTESERQK 1688
Cdd:COG3096    555 LEELLAELEAQLEELEEQAAeavEQRSELRQQLEQLRARIkelaarapawlaaQDALERLREQsGEALadSQEVTAAMQQ 634

                          410       420       430
                   ....*....|....*....|....*....|...
gi 1907079978 1689 AAQRSQAVTQLEAAILQEKDKIyekERTLRDLH 1721
Cdd:COG3096    635 LLEREREATVERDELAARKQAL---ESQIERLS 664
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1604-1744 1.69e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.77  E-value: 1.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1604 ERAARKGREEDVRSLQERIDRAEALRRSWSREEAELQRARDQASQdcgrLQRQLRELEQQKQQKARQLQEEGRLLSQKTE 1683
Cdd:COG1196    213 ERYRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEE----LEAELAELEAELEELRLELEELELELEEAQA 288

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907079978 1684 SERQKAAQRSQAvtqleaailqEKDKIYEKERTLRDLHTKVSREELNQETQTRETNLSTKI 1744
Cdd:COG1196    289 EEYELLAELARL----------EQDIARLEERRRELEERLEELEEELAELEEELEELEEEL 339
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1151-1362 2.00e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 42.83  E-value: 2.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1151 QTLRLQIEEDAARRKGAKETVAKIQARIKDLEQAISSVEPKVIVKEVKKVEQDPG---LLKEASRLRSLLEEEKNNNVAL 1227
Cdd:COG4942     30 EQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAElaeLEKEIAELRAELEAQKEELAEL 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1228 ARELQEL--QEKYRVVEKQKPKVQLQERVSEIFQVLPETEQEIRRLRAQLQETGSKKSGVEQEVEKLLPELEVLRAQKpv 1305
Cdd:COG4942    110 LRALYRLgrQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEER-- 187

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907079978 1306 veyKEVTQEVVRHEKNPEVL-REIDRLKAQLNELVNTNGRSQEQLIRLQGERDEWKRE 1362
Cdd:COG4942    188 ---AALEALKAERQKLLARLeKELAELAAELAELQQEAEELEALIARLEAEAAAAAER 242
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1240-1423 2.25e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.83  E-value: 2.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1240 VVEKQKPKVQLQERVSEIFQVlpetEQEIRRLRAQLQEtgskksgVEQEVEKLLPELEVLRAqkpvvEYKEVTQEVVRHE 1319
Cdd:COG1579      2 MPEDLRALLDLQELDSELDRL----EHRLKELPAELAE-------LEDELAALEARLEAAKT-----ELEDLEKEIKRLE 65

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1320 KNPEVLRE-IDRLKAQLNelvntNGRSQEQLIRLQGERDEWKRERSKVETKMVSKEVVRHEKDPVLEKEAERLRQEVREA 1398
Cdd:COG1579     66 LEIEEVEArIKKYEEQLG-----NVRNNKEYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAEL 140

                          170       180
                   ....*....|....*....|....*
gi 1907079978 1399 VQRRRATEDAVYELQNKLLLLERRR 1423
Cdd:COG1579    141 EEKKAELDEELAELEAELEELEAER 165
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 1211-1591 2.47e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 43.08  E-value: 2.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1211 SRLRSLLEEEKN-NNVALARELQELQEKY---RVVEKQKPKVQLQERV-SEIFQVLPETEQEIRRLRAQLQETGSKksgV 1285
Cdd:NF033838    72 SEIQKSLDKRKHtQNVALNKKLSDIKTEYlyeLNVLKEKSEAELTSKTkKELDAAFEQFKKDTLEPGKKVAEATKK---V 148

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1286 EQEVEKLLPELEVLRAQKPVVEYKevTQEVVRHEKNPEVLR-EIDRLKAQLNElvntngrsqeqlirlqgERDEWKRERS 1364
Cdd:NF033838   149 EEAEKKAKDQKEEDRRNYPTNTYK--TLELEIAESDVEVKKaELELVKEEAKE-----------------PRDEEKIKQA 209

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1365 KVETKMVSKEVVRHEKDPVLEKEAERLRQEVREAVQRRRATEDAVYELQNKLllleRRRPEEQIVVQEVVVTQKDPKLRE 1444
Cdd:NF033838   210 KAKVESKKAEATRLEKIKTDREKAEEEAKRRADAKLKEAVEKNVATSEQDKP----KRRAKRGVLGEPATPDKKENDAKS 285

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1445 EHSrlsrSLDEEVGRRRQLELEVRQLGA--RVEEEE--ARLSFEEDRskklaaeRELRQLTLKIQELEkrppalqekiIM 1520
Cdd:NF033838   286 SDS----SVGEETLPSPSLKPEKKVAEAekKVEEAKkkAKDQKEEDR-------RNYPTNTYKTLELE----------IA 344

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907079978 1521 EEVVKLeKDPDLERSTEALRRELDQEKnrVTELHRECQGLQVQVDLLQKTKSQEKTIYKEVIR--VEKDPVLE 1591
Cdd:NF033838   345 ESDVKV-KEAELELVKEEAKEPRNEEK--IKQAKAKVESKKAEATRLEKIKTDRKKAEEEAKRkaAEEDKVKE 414
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1517-1744 3.04e-03

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 42.65  E-value: 3.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1517 KIIMEEVVKLEKDPDLERSTEALRRELDQEKNRVTELHRECQGLQVQVD-----LLQKTKSQEKTIYKEVIRVEKDPVLE 1591
Cdd:pfam02463  156 LEIEEEAAGSRLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEqakkaLEYYQLKEKLELEEEYLLYLDYLKLN 235

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1592 GERARVWEILNRERAARKGREEDVRSL-QERIDRAEALRRSWSREEAELQRARDQASQDCGRLQRQLRELEQQKQQKARQ 1670
Cdd:pfam02463  236 EERIDLLQELLRDEQEEIESSKQEIEKeEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEK 315

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907079978 1671 L---QEEGRLLSQKTESERQKAAQRSQAVTQLEAAILQEKDKIYEKERTLRDLHTKVSREELNQETQTRETNLSTKI 1744
Cdd:pfam02463  316 LkesEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKL 392
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 1613-1728 3.80e-03

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 42.38  E-value: 3.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1613 EDVRSLQERIDRAEalrrswsREEAELQRARDQASQD-CGRLQRQLRELEQQKQQKARQLQEEgRLLSQKTESERQKAAQ 1691
Cdd:COG0542    411 EELDELERRLEQLE-------IEKEALKKEQDEASFErLAELRDELAELEEELEALKARWEAE-KELIEEIQELKEELEQ 482

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1907079978 1692 RSQAVTQLEAAILQEKDKIYEKERTLRdlhTKVSREE 1728
Cdd:COG0542    483 RYGKIPELEKELAELEEELAELAPLLR---EEVTEED 516
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1466-1776 4.19e-03

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 42.41  E-value: 4.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1466 EVRQLGARVEEEEARLSFEED-------RSKKLAAERELRQLTLKIQELEKRPPALQEKIimeEVVKLEKDPDLE----- 1533
Cdd:pfam15921  188 EIRSILVDFEEASGKKIYEHDsmstmhfRSLGSAISKILRELDTEISYLKGRIFPVEDQL---EALKSESQNKIElllqq 264

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1534 --RSTEALRRELDQEKNRVTE----LHRECQGLQVQVDLLQKTKSQEKTIYKEVirvekdpvLEGERARVWEILNRERAA 1607
Cdd:pfam15921  265 hqDRIEQLISEHEVEITGLTEkassARSQANSIQSQLEIIQEQARNQNSMYMRQ--------LSDLESTVSQLRSELREA 336

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1608 RKGREEDVRSLQERIDRAEAlrrswsrEEAELQRARDQASQDCGRLQRQLREL--EQQKQQKARQLQEE--GRLLSQKTE 1683
Cdd:pfam15921  337 KRMYEDKIEELEKQLVLANS-------ELTEARTERDQFSQESGNLDDQLQKLlaDLHKREKELSLEKEqnKRLWDRDTG 409

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1684 SE------RQKAAQRSQAVTQLEAAILQEKDKIY-EKERTLRDLHTK-VSREELNQETQTRETNLSTKICILEPETGNDM 1755
Cdd:pfam15921  410 NSitidhlRRELDDRNMEVQRLEALLKAMKSECQgQMERQMAAIQGKnESLEKVSSLTAQLESTKEMLRKVVEELTAKKM 489

                          330       340
                   ....*....|....*....|.
gi 1907079978 1756 SpYEAYKRGVIDRGQYLQLQE 1776
Cdd:pfam15921  490 T-LESSERTVSDLTASLQEKE 509
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
978-1179 4.40e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.21  E-value: 4.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  978 QLEEERKRVAEVQRDLEEQRQRLLQLRTQ--QPVARLEEKEVVEFYRDPQLesNLSQAASRVEEEGKRRARLQA---ELE 1052
Cdd:COG4913    611 KLAALEAELAELEEELAEAEERLEALEAEldALQERREALQRLAEYSWDEI--DVASAEREIAELEAELERLDAssdDLA 688

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1053 AVAQKVVHLEGKRKTmqphlltkevtqierdpgLDSQVTQLHSEMQRLRGENGVLTARLEELKDELLALEQKEMNVKEKV 1132
Cdd:COG4913    689 ALEEQLEELEAELEE------------------LEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRAL 750

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 1907079978 1133 VVKEVVKVEKDLEMVKAAQTLRLQIEEDAARRKGAKETVAKIQARIK 1179
Cdd:COG4913    751 LEERFAAALGDAVERELRENLEERIDALRARLNRAEEELERAMRAFN 797
Caldesmon pfam02029
Caldesmon;
1385-1697 4.52e-03

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 41.78  E-value: 4.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1385 EKEAER-LRQEVREAVQRRRATEDAVYELQNKLLLLERRRPEEQIVVQEVVVTQKDP--------KLREEhsRLSRSLDE 1455
Cdd:pfam02029    4 EEEAAReRRRRAREERRRQKEEEEPSGQVTESVEPNEHNSYEEDSELKPSGQGGLDEeeafldrtAKREE--RRQKRLQE 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1456 EVGRRRQLELEVRQLGARVEEEEARLSFEEDRSKKLAAERELRQLTLKIQELEKRPPALQEKIIMEEVVKLEKDPDLERS 1535
Cdd:pfam02029   82 ALERQKEFDPTIADEKESVAERKENNEEEENSSWEKEEKRDSRLGRYKEEETEIREKEYQENKWSTEVRQAEEEGEEEED 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1536 TEALRRELDQEKNRVTELHRECQGLQVQVDLLQKTKSQEKTIYKEViRVEKDPVLEGERARVWEILNRERAARKGREEDV 1615
Cdd:pfam02029  162 KSEEAEEVPTENFAKEEVKDEKIKKEKKVKYESKVFLDQKRGHPEV-KSQNGEEEVTKLKVTTKRRQGGLSQSQEREEEA 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1616 RSLQERIDRAEALRRSWS---REEAELQRARDQ-ASQDCGRL------QRQLRELEQQKQQKARQLQ-----EEGRLLSQ 1680
Cdd:pfam02029  241 EVFLEAEQKLEELRRRRQekeSEEFEKLRQKQQeAELELEELkkkreeRRKLLEEEEQRRKQEEAERklreeEEKRRMKE 320

                          330
                   ....*....|....*..
gi 1907079978 1681 KTESERQKAAQRSQAVT 1697
Cdd:pfam02029  321 EIERRRAEAAEKRQKLP 337
Filament pfam00038
Intermediate filament protein;
1461-1719 4.55e-03

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 41.44  E-value: 4.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1461 RQLELEVRQLGARVEEEEARLSFEEDRSKKLAaERELRQLTLKIQELEKRPPALQEKI--IMEEV----VKLEKDPDLER 1534
Cdd:pfam00038   21 RFLEQQNKLLETKISELRQKKGAEPSRLYSLY-EKEIEDLRRQLDTLTVERARLQLELdnLRLAAedfrQKYEDELNLRT 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1535 STEA----LRRELDQEKNRVTELHRECQGLQVQVDLLQKTKSQE-----KTIYKEVIRVEKDPVLEGERARvweILNRER 1605
Cdd:pfam00038  100 SAENdlvgLRKDLDEATLARVDLEAKIESLKEELAFLKKNHEEEvrelqAQVSDTQVNVEMDAARKLDLTS---ALAEIR 176

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1606 A-----ARKGREEDVRSLQERIdraEALRRSWSREEAELQRARDQASQDCGRLQRQLRELEQQKQQKArqlqeegRLLSQ 1680
Cdd:pfam00038  177 AqyeeiAAKNREEAEEWYQSKL---EELQQAAARNGDALRSAKEEITELRRTIQSLEIELQSLKKQKA-------SLERQ 246

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 1907079978 1681 KTESERQKAAQRSQA---VTQLEAAILQEKDkiyEKERTLRD 1719
Cdd:pfam00038  247 LAETEERYELQLADYqelISELEAELQETRQ---EMARQLRE 285
RGS_LARG cd08754
Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine ...
 637-781 4.75e-03

Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG); The RGS domain is an essential part of the leukemia-associated RhoGEF protein (LARG), a member of the RhoGEF (Rho guanine nucleotide exchange factor) subfamily of the RGS protein family. The RhoGEFs are peripheral membrane proteins that regulate essential cellular processes, including cell shape, cell migration, cell cycle progression of cells, and gene transcription by linking signals from heterotrimeric G-alpha12/13 protein-coupled receptors to Rho GTPase activation, leading to various cellular responses, such as actin reorganization and gene expression. The RhoGEF subfamily includes p115RhoGEF, LARG, PDZ-RhoGEF, and its rat specific splice variant GTRAP48. The RGS domain of RhoGEFs has very little sequence similarity with the canonical RGS domain of the RGS proteins and is often refered to as RH (RGS Homology) domain. In addition to being a G-alpha13 effector, the LARG protein also functions as a GTPase-activating protein (GAP) for G-alpha13. RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development.


Pssm-ID: 188708  Cd Length: 222  Bit Score: 40.75  E-value: 4.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  637 GAEKEAAQQECEAFLSTKPTGSAALQLPVVLNSVKNRYNDVQSLCHLYGEKAKaalglEKQIQEADRVIQGF-----EAA 711
Cdd:cd08754     11 PTESEQINGQCSCFQNIELLKSRPAHLAVFLHHVVSQFDPAALLCYLYADLYK-----QTNSKETRRVFLEFnqfflDRA 85

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907079978  712 LALEGPVPEgsgalqERVSELQRQRKELLQQQacvlgLHRQLKAT--EHACSALQNNFQEFcqdlpRQQRQV 781
Cdd:cd08754     86 ANLKVPVPD------EVSLDLEKRRPELIPEE-----LHRHYIQTmqERVSPEVQRNLEDF-----RQKRSM 141
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
1231-1387 4.98e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 41.77  E-value: 4.98e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1231 LQELQEKYRVVEKQKPKVQLQERVSEifqvLPETEQEIRRLRAQLQETGSKKSGVEQEVEKLLPELEVLRAqkpvvEYKE 1310
Cdd:COG2433    382 LEELIEKELPEEEPEAEREKEHEERE----LTEEEEEIRRLEEQVERLEAEVEELEAELEEKDERIERLER-----ELSE 452

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1311 VTQEVVR-HEKNPEVL---REIDRLKAQLNELVNTNGRSQEQLIRLqgeRDEWKRERS--KVETKMV---SKEVVRHEKD 1381
Cdd:COG2433    453 ARSEERReIRKDREISrldREIERLERELEEERERIEELKRKLERL---KELWKLEHSgeLVPVKVVekfTKEAIRRLEE 529


                   ....*.
gi 1907079978 1382 PVLEKE 1387
Cdd:COG2433    530 EYGLKE 535
Borrelia_P83 pfam05262
Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.
 1596-1734 5.57e-03

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.


Pssm-ID: 114011 [Multi-domain]  Cd Length: 489  Bit Score: 41.53  E-value: 5.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1596 RVWEILNRERAARKGREEDVRSLQERIDRAEALRRSWSREEAELQRAR-DQASQDCGRLQRQL---RELEQQKQQKAR-- 1669
Cdd:pfam05262  181 KVVEALREDNEKGVNFRRDMTDLKERESQEDAKRAQQLKEELDKKQIDaDKAQQKADFAQDNAdkqRDEVRQKQQEAKnl 260

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907079978 1670 -------------QLQEEGRLLSQKTESERQKAAQRSQAVTQLEAAILQEKDKIYEKERTLRDLHTKVSREELNQETQ 1734
Cdd:pfam05262  261 pkpadtsspkedkQVAENQKREIEKAQIEIKKNDEEALKAKDHKAFDLKQESKASEKEAEDKELEAQKKREPVAEDLQ 338
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 910-1539 5.67e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 41.96  E-value: 5.67e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  910 IQAQEKNLAKAYTEVAAAEQQQLRQLEFAKKMLRKKElDEDIQAIHSARQGSGSPAHARTAESEVLKTQ-----LEEERK 984
Cdd:TIGR00606  417 LQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQ-EELKFVIKELQQLEGSSDRILELDQELRKAErelskAEKNSL 495

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  985 RVAEVQRDLEEQRQRLLQLRTQQPVARLEEKEVVEFYRDPQLESNLSQAASRVEEEGKRRARLQAELEAVAQKVVHLEGK 1064
Cdd:TIGR00606  496 TETLKKEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLGYFPNKKQL 575

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1065 RKTMqpHLLTKEVTQIERD-PGLDSQVTQLHSEMQRLRGENGVLTARLEELKDELL-ALEQKEMNVKEKVVVKEVVKVEK 1142
Cdd:TIGR00606  576 EDWL--HSKSKEINQTRDRlAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLFdVCGSQDEESDLERLKEEIEKSSK 653

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1143 DLEMVKAAQTLRLQ-IEEDAARRKGAK-------ETVAKIQARIKDLEQAISSVEPKVIVKEVKKVEQD----------P 1204
Cdd:TIGR00606  654 QRAMLAGATAVYSQfITQLTDENQSCCpvcqrvfQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEkrrdemlglaP 733

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1205 GLLKEASRLRSLLEEEKNNNVALARELQELQEKYRVVEKQKPKVQLQERVSEIFQV-----------LPETEQEIRRLRA 1273
Cdd:TIGR00606  734 GRQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTdvtimerfqmeLKDVERKIAQQAA 813

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1274 QLQETGSKKSGVEQEVEKllpelevlraQKPVVEYKEVTQEVVRHEK-NPEVLREIDRLKAQLNELVNTNGRSQEQLIRl 1352
Cdd:TIGR00606  814 KLQGSDLDRTVQQVNQEK----------QEKQHELDTVVSKIELNRKlIQDQQEQIQHLKSKTNELKSEKLQIGTNLQR- 882

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1353 QGERDEWKRERSKVETKMVSKEVVRHEKDPVLEKEAERLRQEVREAVQRR----RATEDAVYELQNKLLLLERRRPEEQI 1428
Cdd:TIGR00606  883 RQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKetsnKKAQDKVNDIKEKVKNIHGYMKDIEN 962

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1429 VVQEVVVTQKDPKlREEHSRLSRSLDEEVGRRRQLELEVRQLGARVEEEEARLSFEEDRSKKLAAERELRQLTLKIQELE 1508
Cdd:TIGR00606  963 KIQDGKDDYLKQK-ETELNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRENELKEVEEELKQHL 1041

                          650       660       670
                   ....*....|....*....|....*....|.
gi 1907079978 1509 KRPPALQEKIIMEEVVKLEKDPDLERSTEAL 1539
Cdd:TIGR00606 1042 KEMGQMQVLQMKQEHQKLEENIDLIKRNHVL 1072
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
727-1180 7.10e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 41.29  E-value: 7.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  727 ERVSELQRQRKELLQQQACVLGLHRQLKATEHACSALQNNFQEFCQDLPR--QQRQVRALTDRYHAVGDQLDLREKIVQD 804
Cdd:COG4717     71 KELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKleKLLQLLPLYQELEALEAELAELPERLEE 150

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  805 ASLTYQQLRNSRDNLSSWLEQLPHHRVQPSDGPSQISY-KLQAQKRLIQEILGREQDQATVSRLTRDLQEALQDYELQAD 883
Cdd:COG4717    151 LEERLEELRELEEELEELEAELAELQEELEELLEQLSLaTEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELE 230

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  884 TYRCSLEPALAVSAPKRLR----VISLQESIQAQEKNLAKAYTEVAAAEQ--QQLRQLEFAKKMLRKKELDEDIQAIHSA 957
Cdd:COG4717    231 QLENELEAAALEERLKEARllllIAAALLALLGLGGSLLSLILTIAGVLFlvLGLLALLFLLLAREKASLGKEAEELQAL 310

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  958 RQGSGSPAHARTAESEVLKTQLEEERKRVAEVQRDLEEQRQRLLQLRTQQPVARLEEKEvvefyrdPQLESNLSQAASRV 1037
Cdd:COG4717    311 PALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELE-------QEIAALLAEAGVED 383

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1038 EEEGKRRARLQAELEAVAQKVVHLEgkrktMQPHLLTKEVTQIERDPGLDsqvtQLHSEMQRLRGENGVLTARLEELKDE 1117
Cdd:COG4717    384 EEELRAALEQAEEYQELKEELEELE-----EQLEELLGELEELLEALDEE----ELEEELEELEEELEELEEELEELREE 454

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907079978 1118 LLALEQKemnVKEKVVVKEVVKVEKDLEMVKAAQTlrlQIEEDAARRKGAKETVAKIQARIKD 1180
Cdd:COG4717    455 LAELEAE---LEQLEEDGELAELLQELEELKAELR---ELAEEWAALKLALELLEEAREEYRE 511
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1209-1422 7.30e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 41.54  E-value: 7.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1209 EASRLRSLLEEEKNNnvaLARELQELQEKYRVVEKQKPKVQLQERVSEIFQVLPETEQEIRRLRAQLQETGSKKSGVEQE 1288
Cdd:COG3206    172 EARKALEFLEEQLPE---LRKELEEAEAALEEFRQKNGLVDLSEEAKLLLQQLSELESQLAEARAELAEAEARLAALRAQ 248

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1289 VEKLLPELevlraqkpvveykevtQEVVRHEKNPEVLREIDRLKAQLNELVNTNGRSQEQLIRLQGERDEWKRERSKVET 1368
Cdd:COG3206    249 LGSGPDAL----------------PELLQSPVIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQLQQEAQ 312

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907079978 1369 KMVSKevvrhekdpvLEKEAERLRQEVREAVQRRRATEDAVYEL---QNKLLLLERR 1422
Cdd:COG3206    313 RILAS----------LEAELEALQAREASLQAQLAQLEARLAELpelEAELRRLERE 359
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
848-1052 7.81e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 41.44  E-value: 7.81e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  848 KRLIQEILGREQDQATVSRLTRDLQEALQDYELQADTYRcslepALAVSAPKRLRVISLQESIQAQEknlakaytevaaa 927
Cdd:COG4913    613 AALEAELAELEEELAEAEERLEALEAELDALQERREALQ-----RLAEYSWDEIDVASAEREIAELE------------- 674

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  928 eqQQLRQLEFAKKMLRkkELDEDIQAIHSARQGsgspAHARTAESEVLKTQLEEERKRVAEVQRDLEEQRQRLLQLRTQQ 1007
Cdd:COG4913    675 --AELERLDASSDDLA--ALEEQLEELEAELEE----LEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLE 746

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 1907079978 1008 PVARLEEKevVEFYRDPQLESNLSQA-ASRVEEEGKRRARLQAELE 1052
Cdd:COG4913    747 LRALLEER--FAAALGDAVERELRENlEERIDALRARLNRAEEELE 790
PRK15483 PRK15483
type III restriction-modification system endonuclease;
1441-1603 8.65e-03

type III restriction-modification system endonuclease;


Pssm-ID: 237972 [Multi-domain]  Cd Length: 986  Bit Score: 41.17  E-value: 8.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1441 KLREEHSRLSRSldEEVGRrrQLELEVRQLGARVEEEEARLSFEEDRSKKLAAERELRQLTLKiQELEKRPPALQEKIIM 1520
Cdd:PRK15483   525 KLRSSGSETSKL--QEVGR--GLRLPVDENGHRVSQEEFRLNYLIDYDEKDFASKLVGEINSD-SKVQLNEEKLTEEMIQ 599

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1521 EEVVKLEK-DPDLerSTEALRRELDQEK-------------NRVTELHRECQGLQVQVDLLQKTKSQEKTIYKevIRVEK 1586
Cdd:PRK15483   600 KIVTEKQKvDPDF--TELRLLEDLDDKKiidrsnnfkedgfDWLLEAYPELFQTGLRKGKVRDNKPASKLTVK--LRKEN 675

                          170
                   ....*....|....*..
gi 1907079978 1587 DPVLEGerarVWEILNR 1603
Cdd:PRK15483   676 YEELKS----LWEQINR 688
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
970-1284 8.94e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 41.20  E-value: 8.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978  970 AESEVLKTQLEEERKRVAEVQRDLEEQRQRLLQLRTQQPVARLEEK----------EVVEFYRDPQLESN-LSQAASRVE 1038
Cdd:PRK03918   466 KELKEIEEKERKLRKELRELEKVLKKESELIKLKELAEQLKELEEKlkkynleeleKKAEEYEKLKEKLIkLKGEIKSLK 545

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1039 EEGKRRARLQAELEAVAQKVVHLEGKRKTMQPHLLTKEVTQIERDPGLDSQVTQLHSEMQRLRGENGVLTARLEELKDEL 1118
Cdd:PRK03918   546 KELEKLEELKKKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELEPFYNEYLELKDAEKELEREEKELKKLE 625

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1119 LALEQKEMNVKekvvvkevvkvekdlEMVKAAQTLRLQIEEdaARRKGAKETVAKIQARIKDLEQAISsvepkvivkevk 1198
Cdd:PRK03918   626 EELDKAFEELA---------------ETEKRLEELRKELEE--LEKKYSEEEYEELREEYLELSRELA------------ 676

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1199 kveqdpGLLKEASRLRSLLEEeknnnvaLARELQELQEKYRVVEKQKPKVQLQERVSEIFQVLPEteqEIRRLRAQLQET 1278
Cdd:PRK03918   677 ------GLRAELEELEKRREE-------IKKTLEKLKEELEEREKAKKELEKLEKALERVEELRE---KVKKYKALLKER 740


                   ....*.
gi 1907079978 1279 GSKKSG 1284
Cdd:PRK03918   741 ALSKVG 746
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 1523-1701 9.26e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 41.09  E-value: 9.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1523 VVKLEKDPDLERSTE----ALRRELDQEKNRVTELhRECQGLQVQVDLLQKTKSQEKTIYKEVIRVEKDPVLEGERARVW 1598
Cdd:pfam15709  304 VVTGNMESEEERSEEdpskALLEKREQEKASRDRL-RAERAEMRRLEVERKRREQEEQRRLQQEQLERAEKMREELELEQ 382

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1599 EILNRERAARKGREEDvrslqERIDRAEALRRSWSREEAELQRARDQASQdcgrLQRQLRELEQQKQQKA---------- 1668
Cdd:pfam15709  383 QRRFEEIRLRKQRLEE-----ERQRQEEEERKQRLQLQAAQERARQQQEE----FRRKLQELQRKKQQEEaeraeaekqr 453

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1907079978 1669 -----RQLQEEGRLLSQKTESER---QKAAQRSQAVTQLEA 1701
Cdd:pfam15709  454 qkeleMQLAEEQKRLMEMAEEERleyQRQKQEAEEKARLEA 494
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 1618-1714 9.87e-03

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 40.25  E-value: 9.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079978 1618 LQERIDRAEALRRSWS------REEAELQRARDQASQDCGRLQRQLRELEQQKQQKARQLQEEGRLLSQKTESERQKAAQ 1691
Cdd:cd16269    176 LQSKEAEAEAILQADQaltekeKEIEAERAKAEAAEQERKLLEEQQRELEQKLEDQERSYEEHLRQLKEKMEEERENLLK 255

                           90       100
                   ....*....|....*....|...
gi 1907079978 1692 RSQAVTQLEaaiLQEKDKIYEKE 1714
Cdd:cd16269    256 EQERALESK---LKEQEALLEEG 275
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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