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Conserved domains on  [gi|1907189714|ref|XP_036009986|]
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probable tRNA methyltransferase 9B isoform X2 [Mus musculus]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 1904022)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to Penicillium polonicum methyltransferase verB

CATH:  3.40.50.150
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168|GO:0032259|GO:0008757
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiE super family cl43651
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 52-85 9.49e-05

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


The actual alignment was detected with superfamily member COG2226:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 42.29  E-value: 9.49e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1907189714  52 VIHHFstkERRIRAIKEMARVLAPGGQLMIYVWA 85
Cdd:COG2226    96 VLHHL---PDPERALAEIARVLKPGGRLVVVDFS 126
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 52-85 9.49e-05

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 42.29  E-value: 9.49e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1907189714  52 VIHHFstkERRIRAIKEMARVLAPGGQLMIYVWA 85
Cdd:COG2226    96 VLHHL---PDPERALAEIARVLKPGGRLVVVDFS 126
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 52-77 1.53e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 40.24  E-value: 1.53e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907189714  52 VIHHFSTKERRiRAIKEMARVLAPGG 77
Cdd:pfam13649  72 VLHHLPDPDLE-AALREIARVLKPGG 96
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 52-85 9.49e-05

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 42.29  E-value: 9.49e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1907189714  52 VIHHFstkERRIRAIKEMARVLAPGGQLMIYVWA 85
Cdd:COG2226    96 VLHHL---PDPERALAEIARVLKPGGRLVVVDFS 126
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 52-77 1.53e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 40.24  E-value: 1.53e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907189714  52 VIHHFSTKERRiRAIKEMARVLAPGG 77
Cdd:pfam13649  72 VLHHLPDPDLE-AALREIARVLKPGG 96
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 34-81 1.90e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 39.96  E-value: 1.90e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907189714  34 RVRQFLQDQKPGSLVADI-----------------VIHHFstkERRIRAIKEMARVLAPGGQLMI 81
Cdd:pfam08241  33 LAREKAPREGLTFVVGDAedlpfpdnsfdlvlsseVLHHV---EDPERALREIARVLKPGGILII 94
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 48-94 1.82e-03

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 39.13  E-value: 1.82e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1907189714  48 VADIVIHHFStKERRIRAIKEMARVLAPGGQLMIYVWAMEQKNRRFE 94
Cdd:COG0500    99 VAFGVLHHLP-PEEREALLRELARALKPGGVLLLSASDAAAALSLAR 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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