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Conserved domains on  [gi|1868057062|ref|XP_035312427|]
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ankyrin repeat domain-containing protein 55 [Cricetulus griseus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11430360)

ankyrin repeat (ANK) domain-containing protein mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

CATH:  1.25.40.20
Gene Ontology:  GO:0005515
PubMed:  33435370|15152081|17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
5-238 6.05e-40

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 147.41  E-value: 6.05e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062   5 AASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDSYGRTSLCLATYLGWLEGCVSL 84
Cdd:COG0666    60 AAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLL 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062  85 LRNGAKHNIPDKNGRLPLHAATAEPDVRLLIVLLQQSSlsEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDK 164
Cdd:COG0666   140 LEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGA--DVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDN 217

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1868057062 165 DFKTALHWAVQSGNRILCSIILSHHqgpSIINYDDESGKTCVHIAAASGFGDIISDLAKVPECNLQALDVDDRT 238
Cdd:COG0666   218 DGKTALDLAAENGNLEIVKLLLEAG---ADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
Ank_2 pfam12796
Ankyrin repeats (3 copies);
207-292 2.01e-14

Ankyrin repeats (3 copies);


:

Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.99  E-value: 2.01e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 207 HIAAASGFGDIISDLAKvPECNLQALDVDDRTPLHWAAAAGKAECVQSLLElGMDSNLRDiNESTPLAYALYCGHTACVR 286
Cdd:pfam12796   2 HLAAKNGNLELVKLLLE-NGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78


                  ....*.
gi 1868057062 287 LLSQEG 292
Cdd:pfam12796  79 LLLEKG 84
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
5-238 6.05e-40

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 147.41  E-value: 6.05e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062   5 AASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDSYGRTSLCLATYLGWLEGCVSL 84
Cdd:COG0666    60 AAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLL 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062  85 LRNGAKHNIPDKNGRLPLHAATAEPDVRLLIVLLQQSSlsEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDK 164
Cdd:COG0666   140 LEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGA--DVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDN 217

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1868057062 165 DFKTALHWAVQSGNRILCSIILSHHqgpSIINYDDESGKTCVHIAAASGFGDIISDLAKVPECNLQALDVDDRT 238
Cdd:COG0666   218 DGKTALDLAAENGNLEIVKLLLEAG---ADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
PHA03095 PHA03095
ankyrin-like protein; Provisional
 3-286 7.35e-24

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 104.72  E-value: 7.35e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062   3 YQAASNGDVNALTAVIREDPSIlECCDSEGCTPL---MHAVSGRQVDTVKLLLKMGANINTQDSYGRTSLCLATYLGWLE 79
Cdd:PHA03095   19 LLNASNVTVEEVRRLLAAGADV-NFRGEYGKTPLhlyLHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062  80 GCVSLL-RNGAKHNIPDKNGRLPLHA-----ATAEPDVRLLIVLLqqsslSEINHQDTEGMTPLH-WAAFHNRPQHT-QM 151
Cdd:PHA03095   98 DVIKLLiKAGADVNAKDKVGRTPLHVylsgfNINPKVIRLLLRKG-----ADVNALDLYGMTPLAvLLKSRNANVELlRL 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 152 LLKKGADPTLVDKDFKTALHWAVQS---GNRILCSIIlSHHQGPSIINyddESGKTCVHiAAASGFGDIISDLAKVPECN 228
Cdd:PHA03095  173 LIDAGADVYAVDDRFRSLLHHHLQSfkpRARIVRELI-RAGCDPAATD---MLGNTPLH-SMATGSSCKRSLVLPLLIAG 247

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 229 LQ--ALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVR 286
Cdd:PHA03095  248 ISinARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVR 307
Ank_2 pfam12796
Ankyrin repeats (3 copies);
170-266 1.18e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.46  E-value: 1.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 170 LHWAVQSGNRILCSIILSHHQGPsiiNYDDESGKTCVHIAAASGFGDIISDLAKVPECNLQaldVDDRTPLHWAAAAGKA 249
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADA---NLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK---DNGRTALHYAARSGHL 74

                          90
                  ....*....|....*..
gi 1868057062 250 ECVQSLLELGMDSNLRD 266
Cdd:pfam12796  75 EIVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
207-292 2.01e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.99  E-value: 2.01e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 207 HIAAASGFGDIISDLAKvPECNLQALDVDDRTPLHWAAAAGKAECVQSLLElGMDSNLRDiNESTPLAYALYCGHTACVR 286
Cdd:pfam12796   2 HLAAKNGNLELVKLLLE-NGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78


                  ....*.
gi 1868057062 287 LLSQEG 292
Cdd:pfam12796  79 LLLEKG 84
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 198-294 3.16e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 50.25  E-value: 3.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 198 DDESGKTCVHIAAASGFGDIISDLAKVpecNLQAlDVDD---RTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLA 274
Cdd:PLN03192  521 DDPNMASNLLTVASTGNAALLEELLKA---KLDP-DIGDskgRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALW 596

                          90       100
                  ....*....|....*....|
gi 1868057062 275 YALYCGHTACVRLLSQEGRA 294
Cdd:PLN03192  597 NAISAKHHKIFRILYHFASI 616
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 31-59 1.59e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 41.80  E-value: 1.59e-05
                           10        20
                   ....*....|....*....|....*....
gi 1868057062   31 EGCTPLMHAVSGRQVDTVKLLLKMGANIN 59
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 235-264 1.11e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 1.11e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1868057062  235 DDRTPLHWAAAAGKAECVQSLLELGMDSNL 264
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 5-155 1.68e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 41.15  E-value: 1.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062   5 AASNGDVNALTAVIREDPS-ILECCDSE---GCTPLMHAVSGRQVDTVKLLLKMGANINTQD------SYGRTSLClatY 74
Cdd:cd22192    58 AALYDNLEAAVVLMEAAPElVNEPMTSDlyqGETALHIAVVNQNLNLVRELIARGADVVSPRatgtffRPGPKNLI---Y 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062  75 LG----------WLEGCVSLL-RNGAKHNIPDKNGRLPLHAATAEPDVRL------LIV----LLQQSSLSEI-NHQdte 132
Cdd:cd22192   135 YGehplsfaacvGNEEIVRLLiEHGADIRAQDSLGNTVLHILVLQPNKTFacqmydLILsydkEDDLQPLDLVpNNQ--- 211

                         170       180
                  ....*....|....*....|...
gi 1868057062 133 GMTPLHWAAFHNRPQHTQMLLKK 155
Cdd:cd22192   212 GLTPFKLAAKEGNIVMFQHLVQK 234
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
5-238 6.05e-40

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 147.41  E-value: 6.05e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062   5 AASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDSYGRTSLCLATYLGWLEGCVSL 84
Cdd:COG0666    60 AAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLL 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062  85 LRNGAKHNIPDKNGRLPLHAATAEPDVRLLIVLLQQSSlsEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDK 164
Cdd:COG0666   140 LEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGA--DVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDN 217

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1868057062 165 DFKTALHWAVQSGNRILCSIILSHHqgpSIINYDDESGKTCVHIAAASGFGDIISDLAKVPECNLQALDVDDRT 238
Cdd:COG0666   218 DGKTALDLAAENGNLEIVKLLLEAG---ADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
29-273 1.68e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 140.47  E-value: 1.68e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062  29 DSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDSYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAE 108
Cdd:COG0666    51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 109 PDVRLLIVLLQQSslSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSH 188
Cdd:COG0666   131 GNLEIVKLLLEAG--ADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEA 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 189 HqgpSIINYDDESGKTCVHIAAASGFGDIISDLAKVPEcNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDIN 268
Cdd:COG0666   209 G---ADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGA-DLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLD 284


                  ....*
gi 1868057062 269 ESTPL 273
Cdd:COG0666   285 LLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
34-298 2.91e-34

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 131.61  E-value: 2.91e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062  34 TPLMHAVSGRQVDTVKLLLKMGANINTQDSYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDVRL 113
Cdd:COG0666    23 LLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEI 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 114 LIVLLQQSSlsEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHqgps 193
Cdd:COG0666   103 VKLLLEAGA--DVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAG---- 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 194 iinyddesgktcvhiaaasgfgdiisdlakvpeCNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPL 273
Cdd:COG0666   177 ---------------------------------ADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTAL 223

                         250       260
                  ....*....|....*....|....*
gi 1868057062 274 AYALYCGHTACVRLLSQEGRAEPAR 298
Cdd:COG0666   224 DLAAENGNLEIVKLLLEAGADLNAK 248
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
48-288 2.55e-26

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 108.89  E-value: 2.55e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062  48 VKLLLKMGANINTQDSYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAepDVRLLIVLLQQSSLSEIN 127
Cdd:COG0666     4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAAL--AGDLLVALLLLAAGADIN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 128 HQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHqgpsiinyddesgktcvh 207
Cdd:COG0666    82 AKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAG------------------ 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 208 iaaasgfgdiisdlAKVpecNLQalDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVRL 287
Cdd:COG0666   144 --------------ADV---NAQ--DNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKL 204


                  .
gi 1868057062 288 L 288
Cdd:COG0666   205 L 205
PHA03095 PHA03095
ankyrin-like protein; Provisional
 3-286 7.35e-24

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 104.72  E-value: 7.35e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062   3 YQAASNGDVNALTAVIREDPSIlECCDSEGCTPL---MHAVSGRQVDTVKLLLKMGANINTQDSYGRTSLCLATYLGWLE 79
Cdd:PHA03095   19 LLNASNVTVEEVRRLLAAGADV-NFRGEYGKTPLhlyLHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062  80 GCVSLL-RNGAKHNIPDKNGRLPLHA-----ATAEPDVRLLIVLLqqsslSEINHQDTEGMTPLH-WAAFHNRPQHT-QM 151
Cdd:PHA03095   98 DVIKLLiKAGADVNAKDKVGRTPLHVylsgfNINPKVIRLLLRKG-----ADVNALDLYGMTPLAvLLKSRNANVELlRL 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 152 LLKKGADPTLVDKDFKTALHWAVQS---GNRILCSIIlSHHQGPSIINyddESGKTCVHiAAASGFGDIISDLAKVPECN 228
Cdd:PHA03095  173 LIDAGADVYAVDDRFRSLLHHHLQSfkpRARIVRELI-RAGCDPAATD---MLGNTPLH-SMATGSSCKRSLVLPLLIAG 247

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 229 LQ--ALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVR 286
Cdd:PHA03095  248 ISinARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVR 307
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
113-288 4.05e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 88.09  E-value: 4.05e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 113 LLIVLLQQSSLSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRIlcsIILSHHQGP 192
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLL---VALLLLAAG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 193 SIINYDDESGKTCVHIAAASGFGDIISDLAKVPEcNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTP 272
Cdd:COG0666    78 ADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGA-DVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTP 156

                         170
                  ....*....|....*.
gi 1868057062 273 LAYALYCGHTACVRLL 288
Cdd:COG0666   157 LHLAAANGNLEIVKLL 172
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 39-194 9.73e-17

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 82.79  E-value: 9.73e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062  39 AVSGRQVDTVKLLLKMGANINTQDSYGRTSL--CLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLIV 116
Cdd:PHA03100   80 YNLTDVKEIVKLLLEYGANVNAPDNNGITPLlyAISKKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLKIL 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 117 --LLQQ--------------SSLSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRI 180
Cdd:PHA03100  160 klLIDKgvdinaknrvnyllSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKE 239

                         170
                  ....*....|....
gi 1868057062 181 LCSIILSHhqGPSI 194
Cdd:PHA03100  240 IFKLLLNN--GPSI 251
Ank_2 pfam12796
Ankyrin repeats (3 copies);
170-266 1.18e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.46  E-value: 1.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 170 LHWAVQSGNRILCSIILSHHQGPsiiNYDDESGKTCVHIAAASGFGDIISDLAKVPECNLQaldVDDRTPLHWAAAAGKA 249
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADA---NLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK---DNGRTALHYAARSGHL 74

                          90
                  ....*....|....*..
gi 1868057062 250 ECVQSLLELGMDSNLRD 266
Cdd:pfam12796  75 EIVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
36-163 7.59e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.14  E-value: 7.59e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062  36 LMHAVSGRQVDTVKLLLKMGANINTQDSYGRTSLCLATYLGWLEgCVSLLrngAKHNIPDKngrlplhaataepdvrlli 115
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLE-IVKLL---LEHADVNL------------------- 57

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1868057062 116 vllqqsslseinhqDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVD 163
Cdd:pfam12796  58 --------------KDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
207-292 2.01e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.99  E-value: 2.01e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 207 HIAAASGFGDIISDLAKvPECNLQALDVDDRTPLHWAAAAGKAECVQSLLElGMDSNLRDiNESTPLAYALYCGHTACVR 286
Cdd:pfam12796   2 HLAAKNGNLELVKLLLE-NGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78


                  ....*.
gi 1868057062 287 LLSQEG 292
Cdd:pfam12796  79 LLLEKG 84
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 33-292 5.95e-14

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 73.93  E-value: 5.95e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062  33 CTPLMHAVSGRQVDTVKLLLKMGANINTQDSYGRTSLclatylgwlegcvSLLRNgAKHNIPDkngrlplhaataepDVR 112
Cdd:PHA03100   36 VLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPL-------------HYLSN-IKYNLTD--------------VKE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 113 LLIVLLQQSSLseINHQDTEGMTPLHWAAfHNRPQHTQM---LLKKGADPTLVDKDFKTALHWAVQSGNRIL--CSIILS 187
Cdd:PHA03100   88 IVKLLLEYGAN--VNAPDNNGITPLLYAI-SKKSNSYSIveyLLDNGANVNIKNSDGENLLHLYLESNKIDLkiLKLLID 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 188 HhqgpsIINYDdesGKTCVHIAAASGfgdiisdlakvpeCNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDI 267
Cdd:PHA03100  165 K-----GVDIN---AKNRVNYLLSYG-------------VPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNK 223

                         250       260
                  ....*....|....*....|....*
gi 1868057062 268 NESTPLAYALYCGHTACVRLLSQEG 292
Cdd:PHA03100  224 YGDTPLHIAILNNNKEIFKLLLNNG 248
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 23-209 3.16e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 71.92  E-value: 3.16e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062  23 SILECC------DSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDSYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDK 96
Cdd:PHA02874  109 TILDCGidvnikDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDN 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062  97 NGRLPLHAATAEPDVRLLIVLLQQSslSEINHQDTEGMTPLHWAAFHNRPqhTQMLLKKGADPTLVDKDFKTALHWAVQS 176
Cdd:PHA02874  189 NGESPLHNAAEYGDYACIKLLIDHG--NHIMNKCKNGFTPLHNAIIHNRS--AIELLINNASINDQDIDGSTPLHHAINP 264

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1868057062 177 GNRILCSIILSHHQGPsiINYDDESGKTCVHIA 209
Cdd:PHA02874  265 PCDIDIIDILLYHKAD--ISIKDNKGENPIDTA 295
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 8-277 5.78e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 71.15  E-value: 5.78e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062   8 NGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDSYGRTSLCLATYLG-------WLEG 80
Cdd:PHA02874   11 SGDIEAIEKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGahdiiklLIDN 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062  81 CV----------------SLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLIVLLQQSslSEINHQDTEGMTPLHWAAFHN 144
Cdd:PHA02874   91 GVdtsilpipciekdmikTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYG--ADVNIEDDNGCYPIHIAIKHN 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 145 RPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHhqGPSIINyDDESGKTCVHIAaasgfgdIISDLAKV 224
Cdd:PHA02874  169 FFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDH--GNHIMN-KCKNGFTPLHNA-------IIHNRSAI 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1868057062 225 P----ECNLQALDVDDRTPLHWA-AAAGKAECVQSLLELGMDSNLRDINESTPLAYAL 277
Cdd:PHA02874  239 EllinNASINDQDIDGSTPLHHAiNPPCDIDIIDILLYHKADISIKDNKGENPIDTAF 296
PHA03095 PHA03095
ankyrin-like protein; Provisional
 28-194 1.25e-12

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 70.05  E-value: 1.25e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062  28 CDSEGCTPLMHAVSGRQVD--TVKLLLKMGANINTQDSYGRTSL-CLATYLGWLEGCVS-LLRNGAKHNIPDKNGRLPLH 103
Cdd:PHA03095  148 LDLYGMTPLAVLLKSRNANveLLRLLIDAGADVYAVDDRFRSLLhHHLQSFKPRARIVReLIRAGCDPAATDMLGNTPLH 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 104 -AATAEPDVRLLIVLLQQSSLSeINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILC 182
Cdd:PHA03095  228 sMATGSSCKRSLVLPLLIAGIS-INARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAV 306

                         170
                  ....*....|..
gi 1868057062 183 SIILSHHqgPSI 194
Cdd:PHA03095  307 RAALAKN--PSA 316
Ank_2 pfam12796
Ankyrin repeats (3 copies);
4-95 1.39e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.60  E-value: 1.39e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062   4 QAASNGDVNALTAVIREDPSIlECCDSEGCTPLMHAVSGRQVDTVKLLLKmGANINTQDsYGRTSLCLATYLGWLEGCVS 83
Cdd:pfam12796   3 LAAKNGNLELVKLLLENGADA-NLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|..
gi 1868057062  84 LLRNGAKHNIPD 95
Cdd:pfam12796  80 LLEKGADINVKD 91
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 9-276 1.77e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 70.09  E-value: 1.77e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062   9 GDVNALTAvirEDPSILECcdsegctplmhAVSGRQVDTVKLLLKMGANINTQDsygrTSLCLATYLGWLEGCVSLLRNG 88
Cdd:PHA02876  202 ADVNIIAL---DDLSVLEC-----------AVDSKNIDTIKAIIDNRSNINKND----LSLLKAIRNEDLETSLLLYDAG 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062  89 AKHNIPDKNGRLPLHAATAEPDV-RLLIVLLQQSslSEINHQDTEGMTPLHWAAFHN-RPQHTQMLLKKGADPTLVDKDF 166
Cdd:PHA02876  264 FSVNSIDDCKNTPLHHASQAPSLsRLVPKLLERG--ADVNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLY 341

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 167 KTALHWAvQSGNRILCSIILSHHQGPSiINYDDESGKTCVHIAAASGFGDIISDLAKVpECNLQALDVDDRTPLHWA-AA 245
Cdd:PHA02876  342 ITPLHQA-STLDRNKDIVITLLELGAN-VNARDYCDKTPIHYAAVRNNVVIINTLLDY-GADIEALSQKIGTALHFAlCG 418

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1868057062 246 AGKAECVQSLLELGMDSNLRDINESTPLAYA 276
Cdd:PHA02876  419 TNPYMSVKTLIDRGANVNSKNKDLSTPLHYA 449
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 34-292 3.39e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 69.32  E-value: 3.39e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062  34 TPLMHAVSGRQVDT-VKLLLKMGANINTQDSYGRTSLCLATYLGW-LEGCVSLLRNGAKHNIPDKNGRLPLH-AATAEPD 110
Cdd:PHA02876  275 TPLHHASQAPSLSRlVPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHqASTLDRN 354

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 111 VRLLIVLLQQSSlsEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILcsiilshhq 190
Cdd:PHA02876  355 KDIVITLLELGA--NVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPYM--------- 423

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 191 gpsiinyddeSGKTCVHIAAasgfgdiisdlakvpecNLQALDVDDRTPLHWAAAAG-KAECVQSLLELGMDSNLRDINE 269
Cdd:PHA02876  424 ----------SVKTLIDRGA-----------------NVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQN 476

                         250       260
                  ....*....|....*....|...
gi 1868057062 270 STPLAYALycGHTACVRLLSQEG 292
Cdd:PHA02876  477 QYPLLIAL--EYHGIVNILLHYG 497
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 36-264 1.79e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 66.17  E-value: 1.79e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062  36 LMHAVSGRQVDTVKLLLKMGANINTQDSYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLI 115
Cdd:PHA02875    6 LCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 116 VLLQQSS-LSEINHQDteGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHqgpSI 194
Cdd:PHA02875   86 ELLDLGKfADDVFYKD--GMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHK---AC 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1868057062 195 INYDDESGKTCVHIAAASGFGDI---ISDLAKVPECNLQALDVddrTPLHWAAAAGKAECVQSLLELGMDSNL 264
Cdd:PHA02875  161 LDIEDCCGCTPLIIAMAKGDIAIckmLLDSGANIDYFGKNGCV---AALCYAIENNKIDIVRLFIKRGADCNI 230
Ank_2 pfam12796
Ankyrin repeats (3 copies);
240-288 1.10e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 58.20  E-value: 1.10e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1868057062 240 LHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVRLL 288
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLL 49
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 32-196 1.27e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 63.75  E-value: 1.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062  32 GCTPLMHAVSGRQVDTVKLLLKMGANINTQDSYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAE-PD 110
Cdd:PHA02878  168 GNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYcKD 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 111 VRLLIVLLQQSSlsEINHQDT-EGMTPLHwAAFHNrPQHTQMLLKKGADPTLVDKDFKTALHWAVQS------GNRILCS 183
Cdd:PHA02878  248 YDILKLLLEHGV--DVNAKSYiLGLTALH-SSIKS-ERKLKLLLEYGADINSLNSYKLTPLSSAVKQylciniGRILISN 323

                         170
                  ....*....|...
gi 1868057062 184 IILSHHQGPSIIN 196
Cdd:PHA02878  324 ICLLKRIKPDIKN 336
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 2-162 1.73e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 63.09  E-value: 1.73e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062   2 VYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDSYGRTSLCLATYLGWLEGC 81
Cdd:PHA02875   72 LHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGI 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062  82 VSLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLIVLLqqSSLSEINHQDTEG-MTPLHWAAFHNRPQHTQMLLKKGADPT 160
Cdd:PHA02875  152 ELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLL--DSGANIDYFGKNGcVAALCYAIENNKIDIVRLFIKRGADCN 229


                  ..
gi 1868057062 161 LV 162
Cdd:PHA02875  230 IM 231
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 33-289 5.64e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 61.82  E-value: 5.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062  33 CTPLMHAVSGRQVDTVKLLLKMGANINTQDSYGRTSL---CLA--------------------TYLGWLEGC-------- 81
Cdd:PHA02878   38 FIPLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLhiiCKEpnklgmkemirsinkcsvfyTLVAIKDAFnnrnveif 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062  82 VSLLRNGAKHN--IPDKNgrlpLHAATAEPDVRLLIVLLQQSSLSEINHQDTE-GMTPLHWAAFHNRPQHTQMLLKKGAD 158
Cdd:PHA02878  118 KIILTNRYKNIqtIDLVY----IDKKSKDDIIEAEITKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGAN 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 159 PTLVDKDFKTALHWAVQSGNRILCSIILshhQGPSIINYDDESGKTCVHIAAASGFG-DIISDLAKVPEC-NLQAlDVDD 236
Cdd:PHA02878  194 VNIPDKTNNSPLHHAVKHYNKPIVHILL---ENGASTDARDKCGNTPLHISVGYCKDyDILKLLLEHGVDvNAKS-YILG 269

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1868057062 237 RTPLHwaAAAGKAECVQSLLELGMDSNLRDINESTPLAYAL--YCGHTACVRLLS 289
Cdd:PHA02878  270 LTALH--SSIKSERKLKLLLEYGADINSLNSYKLTPLSSAVkqYLCINIGRILIS 322
Ank_2 pfam12796
Ankyrin repeats (3 copies);
102-188 7.08e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.89  E-value: 7.08e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 102 LHAATAEPDVRLLIVLLQQSSlsEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKgADPTLVDKDfKTALHWAVQSGNRIL 181
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGA--DANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNG-RTALHYAARSGHLEI 76


                  ....*..
gi 1868057062 182 CSIILSH 188
Cdd:pfam12796  77 VKLLLEK 83
Ank_4 pfam13637
Ankyrin repeats (many copies);
237-288 8.89e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.59  E-value: 8.89e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1868057062 237 RTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVRLL 288
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 49-276 2.27e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 60.08  E-value: 2.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062  49 KLLLKMGANINTQDSYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLIVLLQQSslSEINH 128
Cdd:PHA02876  162 EMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNR--SNINK 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 129 QDTEGMTplhwaAFHNRPQHTQMLL-KKGADPTLVDKDFKTALHWAVQSGNriLCSIILSHHQGPSIINYDDESGKTCVH 207
Cdd:PHA02876  240 NDLSLLK-----AIRNEDLETSLLLyDAGFSVNSIDDCKNTPLHHASQAPS--LSRLVPKLLERGADVNAKNIKGETPLY 312

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1868057062 208 IAAASGFgdiisDLAKVPECNLQALDVD--DR---TPLHWAAAAGK-AECVQSLLELGMDSNLRDINESTPLAYA 276
Cdd:PHA02876  313 LMAKNGY-----DTENIRTLIMLGADVNaaDRlyiTPLHQASTLDRnKDIVITLLELGANVNARDYCDKTPIHYA 382
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 113-273 5.84e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 55.84  E-value: 5.84e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 113 LLIVLLQQSSLSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHqgp 192
Cdd:PHA02876  158 LLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNR--- 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 193 SIINYDDESgktcvHIAAASGFGDIISDLAKVPECNLQALDVDDRTPLHWAAAAGK-AECVQSLLELGMDSNLRDINEST 271
Cdd:PHA02876  235 SNINKNDLS-----LLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKNIKGET 309


                  ..
gi 1868057062 272 PL 273
Cdd:PHA02876  310 PL 311
Ank_5 pfam13857
Ankyrin repeats (many copies);
227-276 7.51e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 49.27  E-value: 7.51e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1868057062 227 CNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYA 276
Cdd:pfam13857   7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_2 pfam12796
Ankyrin repeats (3 copies);
3-62 1.14e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 49.73  E-value: 1.14e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062   3 YQAASNGDVNALTAVIREDPSileCCDSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQD 62
Cdd:pfam12796  35 HLAAKNGHLEIVKLLLEHADV---NLKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 111-190 1.21e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 54.52  E-value: 1.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 111 VRLLIvllqqSSLSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQ 190
Cdd:PTZ00322   98 ARILL-----TGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQ 172
Ank_4 pfam13637
Ankyrin repeats (many copies);
133-178 1.25e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.42  E-value: 1.25e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1868057062 133 GMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGN 178
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGN 46
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 66-292 1.79e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 53.84  E-value: 1.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062  66 RTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLIVLLQQSSLSEINHQDTEgmTPLHWAAFHNR 145
Cdd:PHA02875    3 QVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIE--SELHDAVEEGD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 146 PQHTQMLLKKGadpTLVD----KDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDesgKTCVHIAAASGFGDIISDL 221
Cdd:PHA02875   81 VKAVEELLDLG---KFADdvfyKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDK---FSPLHLAVMMGDIKGIELL 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1868057062 222 AKVPECnlqaLDVDD---RTPLHWAAAAGKAECVQSLLELGMDSNLRDIN-ESTPLAYALYCGHTACVRLLSQEG 292
Cdd:PHA02875  155 IDHKAC----LDIEDccgCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNgCVAALCYAIENNKIDIVRLFIKRG 225
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 127-351 1.13e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 51.15  E-value: 1.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 127 NHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDesGKTCV 206
Cdd:PHA02875   29 NFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYKD--GMTPL 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 207 HIAAASGFGDIISDLAKVpECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVR 286
Cdd:PHA02875  107 HLATILKKLDIMKLLIAR-GADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICK 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 287 LLSQEGrAEP----ARP------LPSQNSRPQ------KKEGRFNVFNQI-------------FCKNKKEEQ-------- 329
Cdd:PHA02875  186 MLLDSG-ANIdyfgKNGcvaalcYAIENNKIDivrlfiKRGADCNIMFMIegeectildmicnMCTNLESEAidaliadi 264

                         250       260
                  ....*....|....*....|....
gi 1868057062 330 --KAHQKDHSRDRHKEDNTSEVND 351
Cdd:PHA02875  265 aiRIHKKTIRRDEGFKNNMSTIED 288
Ank_5 pfam13857
Ankyrin repeats (many copies);
118-173 2.54e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 44.64  E-value: 2.54e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1868057062 118 LQQSSLSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWA 173
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 198-294 3.16e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 50.25  E-value: 3.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 198 DDESGKTCVHIAAASGFGDIISDLAKVpecNLQAlDVDD---RTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLA 274
Cdd:PLN03192  521 DDPNMASNLLTVASTGNAALLEELLKA---KLDP-DIGDskgRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALW 596

                          90       100
                  ....*....|....*....|
gi 1868057062 275 YALYCGHTACVRLLSQEGRA 294
Cdd:PLN03192  597 NAISAKHHKIFRILYHFASI 616
PHA02946 PHA02946
ankyin-like protein; Provisional
 127-273 6.10e-06

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 48.90  E-value: 6.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 127 NHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGktCV 206
Cdd:PHA02946   66 NETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDEVIERINLLVQYGAKINNSVDEEG--CG 143

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1868057062 207 HIAAASGFGDIIsdLAKVPECNLQALDVD----DRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPL 273
Cdd:PHA02946  144 PLLACTDPSERV--FKKIMSIGFEARIVDkfgkNHIHRHLMSDNPKASTISWMMKLGISPSKPDHDGNTPL 212
Ank_4 pfam13637
Ankyrin repeats (many copies);
98-153 9.55e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.03  E-value: 9.55e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1868057062  98 GRLPLHAATAEPDVRLLIVLLQqsSLSEINHQDTEGMTPLHWAAFHNRPQHTQMLL 153
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLE--KGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
18-72 1.15e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.10  E-value: 1.15e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1868057062  18 IREDPSILECCDSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDSYGRTSLCLA 72
Cdd:pfam13857   2 LEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 31-59 1.59e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 41.80  E-value: 1.59e-05
                           10        20
                   ....*....|....*....|....*....
gi 1868057062   31 EGCTPLMHAVSGRQVDTVKLLLKMGANIN 59
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
PHA02798 PHA02798
ankyrin-like protein; Provisional
 45-223 4.53e-05

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 46.37  E-value: 4.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062  45 VDTVKLLLKMGANINTQDSYGRTSLC-----LATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAataepdvrllivLLQ 119
Cdd:PHA02798   51 TDIVKLFINLGANVNGLDNEYSTPLCtilsnIKDYKHMLDIVKILIENGADINKKNSDGETPLYC------------LLS 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 120 QSSLseinhqdtegmtplhwaafhNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSII-LSHHQGPSIINYD 198
Cdd:PHA02798  119 NGYI--------------------NNLEILLFMIENGADTTLLDKDGFTMLQVYLQSNHHIDIEIIkLLLEKGVDINTHN 178

                         170       180
                  ....*....|....*....|....*
gi 1868057062 199 DESGKTCVHIAAASGFGDIISDLAK 223
Cdd:PHA02798  179 NKEKYDTLHCYFKYNIDRIDADILK 203
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 31-62 9.32e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.58  E-value: 9.32e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1868057062  31 EGCTPLMHAV-SGRQVDTVKLLLKMGANINTQD 62
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 132-164 1.02e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.58  E-value: 1.02e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1868057062 132 EGMTPLHWAAFH-NRPQHTQMLLKKGADPTLVDK 164
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 233-289 1.33e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.89  E-value: 1.33e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1868057062 233 DVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVRLLS 289
Cdd:PTZ00322  112 DYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 132-159 1.49e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 39.16  E-value: 1.49e-04
                          10        20
                  ....*....|....*....|....*...
gi 1868057062 132 EGMTPLHWAAFHNRPQHTQMLLKKGADP 159
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADI 28
PHA02791 PHA02791
ankyrin-like protein; Provisional
 95-178 1.76e-04

ankyrin-like protein; Provisional


Pssm-ID: 165154 [Multi-domain]  Cd Length: 284  Bit Score: 43.88  E-value: 1.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062  95 DKNGRLPLHAATAEPDVRLLIVLLQQSSLSEInhqdTEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAV 174
Cdd:PHA02791   27 DVHGHSALYYAIADNNVRLVCTLLNAGALKNL----LENEFPLHQAATLEDTKIVKILLFSGMDDSQFDDKGNTALYYAV 102


                  ....
gi 1868057062 175 QSGN 178
Cdd:PHA02791  103 DSGN 106
Ank_4 pfam13637
Ankyrin repeats (many copies);
34-85 1.88e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.57  E-value: 1.88e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1868057062  34 TPLMHAVSGRQVDTVKLLLKMGANINTQDSYGRTSLCLATYLGWLEgCVSLL 85
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVE-VLKLL 53
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 21-127 1.94e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.50  E-value: 1.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062  21 DPSILECCDSEGCTplmHAVSGRQVDtVKLLLKMGANINTQDSYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRL 100
Cdd:PTZ00322   75 DPVVAHMLTVELCQ---LAASGDAVG-ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKT 150

                          90       100
                  ....*....|....*....|....*..
gi 1868057062 101 PLHAAtAEPDVRLLIVLLQQSSLSEIN 127
Cdd:PTZ00322  151 PLELA-EENGFREVVQLLSRHSQCHFE 176
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 152-292 2.07e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 44.47  E-value: 2.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 152 LLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGpsiINYDDESGKTCVHIAAASGFGDIISDL-----AKVPE 226
Cdd:PLN03192  544 LLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACN---VHIRDANGNTALWNAISAKHHKIFRILyhfasISDPH 620

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1868057062 227 CnlqALDVddrtpLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVRLLSQEG 292
Cdd:PLN03192  621 A---AGDL-----LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNG 678
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 132-161 2.21e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.72  E-value: 2.21e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1868057062  132 EGMTPLHWAAFHNRPQHTQMLLKKGADPTL 161
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 150-231 2.89e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 43.73  E-value: 2.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 150 QMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIInydDESGKTCVHIAAASGFGDIISDLAKVPECNL 229
Cdd:PTZ00322   99 RILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLL---DKDGKTPLELAEENGFREVVQLLSRHSQCHF 175


                  ..
gi 1868057062 230 QA 231
Cdd:PTZ00322  176 EL 177
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 235-266 3.84e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.04  E-value: 3.84e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1868057062 235 DDRTPLHWAAA-AGKAECVQSLLELGMDSNLRD 266
Cdd:pfam00023   1 DGNTPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 51-177 3.91e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 43.32  E-value: 3.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062  51 LLKMGANINTQDSYGRTSLCLATYLGWlEGCV-SLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLIVLLQQSSLSEINhq 129
Cdd:PLN03192  544 LLKAKLDPDIGDSKGRTPLHIAASKGY-EDCVlVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFASISDPH-- 620

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1868057062 130 dtEGMTPLHWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSG 177
Cdd:PLN03192  621 --AAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAED 666
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 31-60 5.15e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 37.62  E-value: 5.15e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 1868057062  31 EGCTPLMHAVSGRQVDTVKLLLKMGANINT 60
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
PHA02798 PHA02798
ankyrin-like protein; Provisional
 29-138 7.61e-04

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 42.13  E-value: 7.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062  29 DSEGCTPLMHAVSG-----RQVDTVKLLLKMGANINTQDSYGRTSLCLA---TYLGWLEGCVSLLRNGAKHNIPDKNGRL 100
Cdd:PHA02798   68 DNEYSTPLCTILSNikdykHMLDIVKILIENGADINKKNSDGETPLYCLlsnGYINNLEILLFMIENGADTTLLDKDGFT 147

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1868057062 101 PLHA---ATAEPDVRLLIVLLQQSslSEIN-HQDTEGMTPLH 138
Cdd:PHA02798  148 MLQVylqSNHHIDIEIIKLLLEKG--VDINtHNNKEKYDTLH 187
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 2-165 8.90e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 42.16  E-value: 8.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062   2 VYQAASNGDVNALTAVIR--EDPSIlecCDSEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDSYGRTSLCLATYLGWLE 79
Cdd:PLN03192  529 LLTVASTGNAALLEELLKakLDPDI---GDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHK 605

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062  80 gCVSLLRNGAKHNIPDKNGRLpLHAATAEPDVRLLIVLLQQSslSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKKGADP 159
Cdd:PLN03192  606 -IFRILYHFASISDPHAAGDL-LCTAAKRNDLTAMKELLKQG--LNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADV 681


                  ....*.
gi 1868057062 160 TLVDKD 165
Cdd:PLN03192  682 DKANTD 687
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 220-297 1.05e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.19  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 220 DLAKVPECNLQALDVDDRTPLHWA-------AAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVRLLSQEG 292
Cdd:PTZ00322   59 NKDATPDHNLTTEEVIDPVVAHMLtvelcqlAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFG 138


                  ....*
gi 1868057062 293 rAEPA 297
Cdd:PTZ00322  139 -ADPT 142
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 235-264 1.11e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 1.11e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1868057062  235 DDRTPLHWAAAAGKAECVQSLLELGMDSNL 264
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 5-155 1.68e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 41.15  E-value: 1.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062   5 AASNGDVNALTAVIREDPS-ILECCDSE---GCTPLMHAVSGRQVDTVKLLLKMGANINTQD------SYGRTSLClatY 74
Cdd:cd22192    58 AALYDNLEAAVVLMEAAPElVNEPMTSDlyqGETALHIAVVNQNLNLVRELIARGADVVSPRatgtffRPGPKNLI---Y 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062  75 LG----------WLEGCVSLL-RNGAKHNIPDKNGRLPLHAATAEPDVRL------LIV----LLQQSSLSEI-NHQdte 132
Cdd:cd22192   135 YGehplsfaacvGNEEIVRLLiEHGADIRAQDSLGNTVLHILVLQPNKTFacqmydLILsydkEDDLQPLDLVpNNQ--- 211

                         170       180
                  ....*....|....*....|...
gi 1868057062 133 GMTPLHWAAFHNRPQHTQMLLKK 155
Cdd:cd22192   212 GLTPFKLAAKEGNIVMFQHLVQK 234
Ank_4 pfam13637
Ankyrin repeats (many copies);
168-221 5.04e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.33  E-value: 5.04e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1868057062 168 TALHWAVQSGNRILCSIILSHhqgPSIINYDDESGKTCVHIAAASGFGDIISDL 221
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEK---GADINAVDGNGETALHFAASNGNVEVLKLL 53
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 235-263 6.64e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 34.54  E-value: 6.64e-03
                          10        20
                  ....*....|....*....|....*....
gi 1868057062 235 DDRTPLHWAAAAGKAECVQSLLELGMDSN 263
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
PHA02946 PHA02946
ankyin-like protein; Provisional
 23-230 6.89e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 39.27  E-value: 6.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062  23 SILECCDSEGCTPLMHA---VSGRQVDTVKLLLKMGANINTQDSYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGR 99
Cdd:PHA02946   27 NMLQAIEPSGNYHILHAycgIKGLDERFVEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHK 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 100 LPLHAATAEPD-VRLLIVLLQQSSLSEINHQDTEGMTPLhWAAFHNRPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGN 178
Cdd:PHA02946  107 TPLYYLSGTDDeVIERINLLVQYGAKINNSVDEEGCGPL-LACTDPSERVFKKIMSIGFEARIVDKFGKNHIHRHLMSDN 185

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1868057062 179 RILCSIILSHHQGPSiINYDDESGKTCVHIAAASGFG--DIISDLAKVPECNLQ 230
Cdd:PHA02946  186 PKASTISWMMKLGIS-PSKPDHDGNTPLHIVCSKTVKnvDIINLLLPSTDVNKQ 238
Ank_4 pfam13637
Ankyrin repeats (many copies);
65-118 7.70e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 34.94  E-value: 7.70e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1868057062  65 GRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDVRLLIVLL 118
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 100-178 8.09e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 39.23  E-value: 8.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868057062 100 LPLHAATAEPDVRLLIVLLQQSSlSEINHQDTEGMTPLHWAAFHNRPQHTQMLLKkgADPTLVDK----DF---KTALHW 172
Cdd:cd22192    19 SPLLLAAKENDVQAIKKLLKCPS-CDLFQRGALGETALHVAALYDNLEAAVVLME--AAPELVNEpmtsDLyqgETALHI 95


                  ....*.
gi 1868057062 173 AVQSGN 178
Cdd:cd22192    96 AVVNQN 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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