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Conserved domains on  [gi|1845666120|ref|XP_034515586|]
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lysocardiolipin acyltransferase 1 isoform X5 [Ailuropoda melanoleuca]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 10870651)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0016746|GO:0008654|GO:0006644
PubMed:  18287005|18931347|18718904|37611890
SCOP:  4003349

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 1-209 3.59e-83

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


:

Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 250.23  E-value: 3.59e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845666120   1 MFGVKVIITGDAF-VPGERSVIIMNHRTRMDWLFLWNCLMRYSYLRLEKICLKASLKSVPGFGWAMQAAAYIFIHRKWKD 79
Cdd:cd07990     7 LSGVKVVVYGDEPkLPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFLKRKWEK 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845666120  80 DQSHFEDIIDYFCDIREPLQLLIFPEGTDLTENSKARSNDFAEKNGLQKYEYVLHPRTTGFTFVVERLREENvswahmlf 159
Cdd:cd07990    87 DEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDAV-------- 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1845666120 160 gllryqdtahswknlDAVHDITVAYPHNMPQTEKHLLLGDFPKEVHFHVR 209
Cdd:cd07990   159 ---------------DAVYDVTIAYPDGKPPSEQRLLLGGKPREVHVHVR 193
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 194-268 4.75e-18

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


:

Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 77.23  E-value: 4.75e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1845666120 194 HLLLGdFPKEVHFHVRRYPVDTLPESREGLQLWCHKRWEEKEERLRSFYEgEKNFHFTGQTVIPPCKSELRVLVL 268
Cdd:pfam16076   1 SLLNG-KPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYE-TGTFFPGKEHIIPRRLKSLLVFIF 73
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 1-209 3.59e-83

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 250.23  E-value: 3.59e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845666120   1 MFGVKVIITGDAF-VPGERSVIIMNHRTRMDWLFLWNCLMRYSYLRLEKICLKASLKSVPGFGWAMQAAAYIFIHRKWKD 79
Cdd:cd07990     7 LSGVKVVVYGDEPkLPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFLKRKWEK 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845666120  80 DQSHFEDIIDYFCDIREPLQLLIFPEGTDLTENSKARSNDFAEKNGLQKYEYVLHPRTTGFTFVVERLREENvswahmlf 159
Cdd:cd07990    87 DEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDAV-------- 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1845666120 160 gllryqdtahswknlDAVHDITVAYPHNMPQTEKHLLLGDFPKEVHFHVR 209
Cdd:cd07990   159 ---------------DAVYDVTIAYPDGKPPSEQRLLLGGKPREVHVHVR 193
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 3-288 4.95e-55

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 183.75  E-value: 4.95e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845666120   3 GVKVIITGDAFVPGERSVIIMNHRTRMDWLFLWNCLMRYSYLRLEKICLKASLKSVPGFGWAMQAAAYIFIHRKWKDDQS 82
Cdd:PLN02510   78 KTKVVFSGDKVPPEERVLLIANHRTEVDWMYLWDLALRKGCLGYIKYVLKSSLMKLPVFGWAFHIFEFIPVERKWEVDEP 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845666120  83 HFEDIIDYFCDIREPLQLLIFPEGTDLTENSKARSNDFAEKNGLQKYEYVLHPRTTGFTFVVERLREenvswahmlfgll 162
Cdd:PLN02510  158 NIRQMLSSFKDPRDPLWLALFPEGTDYTEAKCQRSQKFAAEHGLPILNNVLLPKTKGFVSCLQELRC------------- 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845666120 163 ryqdtahswkNLDAVHDITVAYPHNMPqTEKHLLLGDFPKEVHFHVRRYPVDTLPESREGLQLWCHKRWEEKEERLRSFY 242
Cdd:PLN02510  225 ----------SLDAVYDVTIGYKHRCP-SFLDNVFGIDPSEVHIHIRRIPLKQIPTSEDEVSAWLMDRFQLKDQLLSDFY 293

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1845666120 243 egeKNFHFTGQTV-----IPPCKSELRVLVLKFLSILYWTLFSpAMCLLIY 288
Cdd:PLN02510  294 ---AQGHFPNEGTegelsTLKCLANFLAVIALTTVFTYLTLFS-SVWFKIY 340
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 194-268 4.75e-18

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 77.23  E-value: 4.75e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1845666120 194 HLLLGdFPKEVHFHVRRYPVDTLPESREGLQLWCHKRWEEKEERLRSFYEgEKNFHFTGQTVIPPCKSELRVLVL 268
Cdd:pfam16076   1 SLLNG-KPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYE-TGTFFPGKEHIIPRRLKSLLVFIF 73
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 20-141 5.00e-18

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 78.55  E-value: 5.00e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845666120   20 VIIMNHRTRMDWLFLWNCLmrYSYLRLEKICLKASLKSVPGFGWAMQAAAYIFIHRKWKDDQSHFedIIDYFCDIREPLQ 99
Cdd:smart00563   2 LVVANHQSFLDPLVLSALL--PRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAA--LREAVELLKEGEW 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1845666120  100 LLIFPEGTDLTENSKARSNDFAEKNGLQKYEYVLhPRTTGFT 141
Cdd:smart00563  78 LLIFPEGTRSRPGKLLPFKKGAARLALEAGVPIV-PVAIRGT 118
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 5-147 4.59e-15

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 70.77  E-value: 4.59e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845666120   5 KVIITGDAFVP-GERSVIIMNHRTRMDWLFLWNCLmrYSYLRLEKICLKASLKSVPGFGWAMQAAAYIFIHRKWKDDQSH 83
Cdd:pfam01553   1 RIEVHGLENLPrGGPAIVVANHQSYLDVLLLSLAL--YKRGRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAG 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1845666120  84 FEDIIDYFcdIREPLQLLIFPEGTdltenskaRSNdfaeknglqkyEYVLHPRTTGFTFVVERL 147
Cdd:pfam01553  79 TLEYLVEL--LREGKLVVIFPEGT--------RSR-----------EGELLPFKKGAFRLAIEA 121
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 1-107 1.23e-13

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 68.88  E-value: 1.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845666120   1 MFGVKVIITGDAFVPGERSVIIM-NHRTRMDWLFLWNCLMRY-SYLrlekicLKASLKSVPGFGWAMQAAAYIFIHR-KW 77
Cdd:COG0204    26 LLGVRVRVEGLENLPADGPVLIVaNHQSWLDILLLLAALPRPvRFV------AKKELFKIPLLGWLLRALGAIPVDRsKR 99

                          90       100       110
                  ....*....|....*....|....*....|
gi 1845666120  78 KDDQSHFEDIIDYfcdIREPLQLLIFPEGT 107
Cdd:COG0204   100 RAALRALRQAVEA---LKAGESLVIFPEGT 126
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 3-107 2.10e-07

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 49.27  E-value: 2.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845666120   3 GVKVIITGDAFVPGERSVIIM-NHRTRMDWLFLwnclmRYSYLRLEKICLKASLKSVPGFGWAMQAAAYIFIHRK-WKDD 80
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVaNHQSNLDPLTL-----SAAFPPPIVFIAKKELKWIPFFGIMLWLTGAIFIDREnIRAI 75

                          90       100
                  ....*....|....*....|....*..
gi 1845666120  81 QSHFEDIIDYfcdIREPLQLLIFPEGT 107
Cdd:TIGR00530  76 ATALKAAIEV---LKQGRSIGVFPEGT 99
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 1-209 3.59e-83

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 250.23  E-value: 3.59e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845666120   1 MFGVKVIITGDAF-VPGERSVIIMNHRTRMDWLFLWNCLMRYSYLRLEKICLKASLKSVPGFGWAMQAAAYIFIHRKWKD 79
Cdd:cd07990     7 LSGVKVVVYGDEPkLPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFLKRKWEK 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845666120  80 DQSHFEDIIDYFCDIREPLQLLIFPEGTDLTENSKARSNDFAEKNGLQKYEYVLHPRTTGFTFVVERLREENvswahmlf 159
Cdd:cd07990    87 DEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDAV-------- 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1845666120 160 gllryqdtahswknlDAVHDITVAYPHNMPQTEKHLLLGDFPKEVHFHVR 209
Cdd:cd07990   159 ---------------DAVYDVTIAYPDGKPPSEQRLLLGGKPREVHVHVR 193
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 3-288 4.95e-55

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 183.75  E-value: 4.95e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845666120   3 GVKVIITGDAFVPGERSVIIMNHRTRMDWLFLWNCLMRYSYLRLEKICLKASLKSVPGFGWAMQAAAYIFIHRKWKDDQS 82
Cdd:PLN02510   78 KTKVVFSGDKVPPEERVLLIANHRTEVDWMYLWDLALRKGCLGYIKYVLKSSLMKLPVFGWAFHIFEFIPVERKWEVDEP 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845666120  83 HFEDIIDYFCDIREPLQLLIFPEGTDLTENSKARSNDFAEKNGLQKYEYVLHPRTTGFTFVVERLREenvswahmlfgll 162
Cdd:PLN02510  158 NIRQMLSSFKDPRDPLWLALFPEGTDYTEAKCQRSQKFAAEHGLPILNNVLLPKTKGFVSCLQELRC------------- 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845666120 163 ryqdtahswkNLDAVHDITVAYPHNMPqTEKHLLLGDFPKEVHFHVRRYPVDTLPESREGLQLWCHKRWEEKEERLRSFY 242
Cdd:PLN02510  225 ----------SLDAVYDVTIGYKHRCP-SFLDNVFGIDPSEVHIHIRRIPLKQIPTSEDEVSAWLMDRFQLKDQLLSDFY 293

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1845666120 243 egeKNFHFTGQTV-----IPPCKSELRVLVLKFLSILYWTLFSpAMCLLIY 288
Cdd:PLN02510  294 ---AQGHFPNEGTegelsTLKCLANFLAVIALTTVFTYLTLFS-SVWFKIY 340
PLN02380 PLN02380
1-acyl-sn-glycerol-3-phosphate acyltransferase
 17-306 1.26e-33

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178006 [Multi-domain]  Cd Length: 376  Bit Score: 127.55  E-value: 1.26e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845666120  17 ERSVIIMNHRTRMDWLFLWNCLMRYSYLRLEKICLKASLKSVPGFGWAMQAAAYIFIHRKWKDDQSHFEDIIDYFCDIRE 96
Cdd:PLN02380   84 EHALVISNHRSDIDWLVGWILAQRSGCLGSALAVMKKSSKFLPVIGWSMWFSEYVFLERSWAKDENTLKSGFQRLKDFPR 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845666120  97 PLQLLIFPEGTDLTENSKARSNDFAEKNGLQKYEYVLHPRTTGFTFVVERLREenvswahmlFgllryqdtahswknLDA 176
Cdd:PLN02380  164 PFWLALFVEGTRFTQAKLLAAQEYAASRGLPVPRNVLIPRTKGFVSAVSNMRS---------F--------------VPA 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845666120 177 VHDITVAYPHNMPQTEKHLLLGDFPKEVHFHVRRYPVDTLPESREGLQLWCHKRWEEKEERLRSFyegEKNFHFTGQTVI 256
Cdd:PLN02380  221 IYDVTVAVPKGQPAPTMLRIFRGQSSVVHVHIKRHSMKELPETDDGIAQWCKDVFVAKDALLDKH---FAEDTFGDQEYQ 297

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1845666120 257 P---PCKSelrVLVLKFLSILywtlfspamcLLIYLYSLVRWYFI------ITVVIFVL 306
Cdd:PLN02380  298 DigrPKKS---LIVVISWACL----------LILGAIKFLQWLSLlsswkgIASLAAGL 343
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 194-268 4.75e-18

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 77.23  E-value: 4.75e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1845666120 194 HLLLGdFPKEVHFHVRRYPVDTLPESREGLQLWCHKRWEEKEERLRSFYEgEKNFHFTGQTVIPPCKSELRVLVL 268
Cdd:pfam16076   1 SLLNG-KPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYE-TGTFFPGKEHIIPRRLKSLLVFIF 73
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 20-141 5.00e-18

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 78.55  E-value: 5.00e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845666120   20 VIIMNHRTRMDWLFLWNCLmrYSYLRLEKICLKASLKSVPGFGWAMQAAAYIFIHRKWKDDQSHFedIIDYFCDIREPLQ 99
Cdd:smart00563   2 LVVANHQSFLDPLVLSALL--PRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAA--LREAVELLKEGEW 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1845666120  100 LLIFPEGTDLTENSKARSNDFAEKNGLQKYEYVLhPRTTGFT 141
Cdd:smart00563  78 LLIFPEGTRSRPGKLLPFKKGAARLALEAGVPIV-PVAIRGT 118
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 5-147 4.59e-15

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 70.77  E-value: 4.59e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845666120   5 KVIITGDAFVP-GERSVIIMNHRTRMDWLFLWNCLmrYSYLRLEKICLKASLKSVPGFGWAMQAAAYIFIHRKWKDDQSH 83
Cdd:pfam01553   1 RIEVHGLENLPrGGPAIVVANHQSYLDVLLLSLAL--YKRGRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAG 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1845666120  84 FEDIIDYFcdIREPLQLLIFPEGTdltenskaRSNdfaeknglqkyEYVLHPRTTGFTFVVERL 147
Cdd:pfam01553  79 TLEYLVEL--LREGKLVVIFPEGT--------RSR-----------EGELLPFKKGAFRLAIEA 121
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 1-107 1.23e-13

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 68.88  E-value: 1.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845666120   1 MFGVKVIITGDAFVPGERSVIIM-NHRTRMDWLFLWNCLMRY-SYLrlekicLKASLKSVPGFGWAMQAAAYIFIHR-KW 77
Cdd:COG0204    26 LLGVRVRVEGLENLPADGPVLIVaNHQSWLDILLLLAALPRPvRFV------AKKELFKIPLLGWLLRALGAIPVDRsKR 99

                          90       100       110
                  ....*....|....*....|....*....|
gi 1845666120  78 KDDQSHFEDIIDYfcdIREPLQLLIFPEGT 107
Cdd:COG0204   100 RAALRALRQAVEA---LKAGESLVIFPEGT 126
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 1-107 7.06e-13

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 66.14  E-value: 7.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845666120   1 MFGVKVIITGDAFVPGERSVIIM-NHRTRMDWLFLWNCLMRY-SYLrlekicLKASLKSVPGFGWAMQAAAYIFIHR-KW 77
Cdd:cd07989     7 LLGVRVRVEGLENLPPKGPVIIVaNHQSYLDPLVLGAALPRPiRFV------AKKELFKIPFLGWLLRLLGAIPIDRgNG 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1845666120  78 KDDQSHFEDIIDYfcdIREPLQLLIFPEGT 107
Cdd:cd07989    81 RSAREALREAIEA---LKEGESVVIFPEGT 107
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 3-143 1.79e-12

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 65.13  E-value: 1.79e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845666120   3 GVKVIITGDAFVPGERSVIIM-NHRTRMDWLFLWnCLMRYSYLRLEKICLKA-SLKSVPGFGWamqaAAYIFIHRKW-KD 79
Cdd:cd06551    11 FVRLEVKGPPPPPGGGPVLFVsNHSSWWDGLILF-LLLERGLRRDVYGLMDEeLLERYPFFTR----LGAFSVDRDSpRS 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1845666120  80 DQSHFEDIIDYFCDIREplQLLIFPEGTDLTEnskarsndfaEKNGLQKYEYVLHP-RTTGFTFV 143
Cdd:cd06551    86 AAKSLKYVARLLSKPGS--VVWIFPEGTRTRR----------DKRPLQFKPGVAHLaEKAGVPIV 138
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 3-107 2.10e-07

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 49.27  E-value: 2.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845666120   3 GVKVIITGDAFVPGERSVIIM-NHRTRMDWLFLwnclmRYSYLRLEKICLKASLKSVPGFGWAMQAAAYIFIHRK-WKDD 80
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVaNHQSNLDPLTL-----SAAFPPPIVFIAKKELKWIPFFGIMLWLTGAIFIDREnIRAI 75

                          90       100
                  ....*....|....*....|....*..
gi 1845666120  81 QSHFEDIIDYfcdIREPLQLLIFPEGT 107
Cdd:TIGR00530  76 ATALKAAIEV---LKQGRSIGVFPEGT 99
PRK14014 PRK14014
putative acyltransferase; Provisional
 103-238 1.36e-05

putative acyltransferase; Provisional


Pssm-ID: 237584 [Multi-domain]  Cd Length: 301  Bit Score: 46.00  E-value: 1.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845666120 103 FPEGTDLTENSKARSNdfaeknglQKYEYVLHPRTTGFTFVVERLREEnvswahmlfgllryqdtahswknLDAVHDITV 182
Cdd:PRK14014  180 FVEGTRFTPEKHQQQQ--------SPYQHLLKPKAGGIAFALNAMGEQ-----------------------FDGLLDVTI 228

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1845666120 183 AYPHNMPqTEKHLLLGDfPKEVHFHVRRYPVDTL--------PESREGLQLWCHKRWEEKEERL 238
Cdd:PRK14014  229 VYPDGRP-SFWDLLSGR-VKKIVVHVRLLPIPEEligdyfndKEFRRRFQQWLNQLWQEKDQLI 290
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 20-107 1.07e-04

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 42.59  E-value: 1.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845666120  20 VIIMNHRTRMDWLFLWNCLMrYSYLRlekiclKASLKSVPGFGWAMQAAAYIFIHR-KWKDDQSHFEDIIDYFCDIREPl 98
Cdd:cd07991    27 IIVANHTSFIDPLILFSDLF-PSIVA------KKELGKLPFIGTILRALGCIFVDRsEPKDRKKVVEEIKERATDPNWP- 98


                  ....*....
gi 1845666120  99 QLLIFPEGT 107
Cdd:cd07991    99 PILIFPEGT 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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