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Conserved domains on  [gi|2565252596|ref|XP_033855928|]
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cellular communication network factor 4b isoform X1 [Acipenser ruthenus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 209-252 2.83e-17

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


:

Pssm-ID: 465952  Cd Length: 44  Bit Score: 74.68  E-value: 2.83e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2565252596 209 CVSQTTPWSPCSKTCGTGLSMRVTNANDQCELVKERRLCNIRPC 252
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
IGFBP pfam00219
Insulin-like growth factor binding protein;
45-97 8.10e-10

Insulin-like growth factor binding protein;


:

Pssm-ID: 459717  Cd Length: 53  Bit Score: 53.87  E-value: 8.10e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2565252596  45 CKWPC---KCPKSPPRCSAGVslVMDGCDCCKACARQVGEKCNEAD-TCDyhKGLYC 97
Cdd:pfam00219   1 CPPPCdpeRCPPPPPGCPAGV--VLDGCGCCKVCARQEGEPCGVYTpPCG--KGLRC 53
VWC smart00214
von Willebrand factor (vWF) type C domain;
119-177 7.23e-06

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 42.89  E-value: 7.23e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2565252596  119 CEDNGVIYRNGQSFQPNCKYKCMCVNGA-IGCVPVcrdSRPPLVWCQNPKRVKVPGKCCE 177
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPV---ECPPPPDCPNPERVKPPGECCP 57
GHB_like super family cl21545
Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the ...
 275-339 3.04e-03

Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the beta chains of gonadotropins, thyrotropins, follitropins, choriogonadotropins and more. The members are reproductive hormones that consist of two glycosylated chains (alpha and beta), which form a tightly bound dimer.


The actual alignment was detected with superfamily member smart00041:

Pssm-ID: 473907  Cd Length: 82  Bit Score: 36.23  E-value: 3.04e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2565252596  275 PKNFTISGCiSKKTYRPKYC-GVCTD------------NRCCIPYKSKTIEVQFECPNGSMFSWPVMWINACFCNLSC 339
Cdd:smart00041   5 RQTITYNGC-TSVTVKNAFCeGKCGSassysiqdvqhsCSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEPNC 81
 
Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 209-252 2.83e-17

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 74.68  E-value: 2.83e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2565252596 209 CVSQTTPWSPCSKTCGTGLSMRVTNANDQCELVKERRLCNIRPC 252
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
IGFBP pfam00219
Insulin-like growth factor binding protein;
45-97 8.10e-10

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 53.87  E-value: 8.10e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2565252596  45 CKWPC---KCPKSPPRCSAGVslVMDGCDCCKACARQVGEKCNEAD-TCDyhKGLYC 97
Cdd:pfam00219   1 CPPPCdpeRCPPPPPGCPAGV--VLDGCGCCKVCARQEGEPCGVYTpPCG--KGLRC 53
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 48-105 7.17e-06

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 43.61  E-value: 7.17e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2565252596   48 PCKCPKSPPRCSAGVslVMDGCDCCKACARQVGEKCNeADTCDYHKGLYCDYSMDKPR 105
Cdd:smart00121   8 PARCPPCPPGCAELV--RLDGCGCCPVCARQEGEPCG-VYTPRCAPGLRCQPPPGEER 62
VWC smart00214
von Willebrand factor (vWF) type C domain;
119-177 7.23e-06

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 42.89  E-value: 7.23e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2565252596  119 CEDNGVIYRNGQSFQPNCKYKCMCVNGA-IGCVPVcrdSRPPLVWCQNPKRVKVPGKCCE 177
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPV---ECPPPPDCPNPERVKPPGECCP 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 119-178 4.34e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 40.87  E-value: 4.34e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2565252596 119 CEDNGVIYRNGQSFQPNCKYKCMCVNGAIGcvpvCRDSRPPLVWCQNPKRVKVPGKCCEQ 178
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVL----CDKIICPPLDCPNPRLEIPPGECCPV 56
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 210-253 1.20e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.41  E-value: 1.20e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2565252596  210 VSQTTPWSPCSKTCGTGLSMRVTNAND--------QC-ELVKERRLCNIRPCE 253
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpppqngggPCtGEDVETRACNEQPCP 53
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 275-339 3.04e-03

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 36.23  E-value: 3.04e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2565252596  275 PKNFTISGCiSKKTYRPKYC-GVCTD------------NRCCIPYKSKTIEVQFECPNGSMFSWPVMWINACFCNLSC 339
Cdd:smart00041   5 RQTITYNGC-TSVTVKNAFCeGKCGSassysiqdvqhsCSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEPNC 81
Cys_knot pfam00007
Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of ...
 274-346 3.57e-03

Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.


Pssm-ID: 394966  Cd Length: 105  Bit Score: 36.61  E-value: 3.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2565252596 274 EPKNFTIS----GCISKKTYRPKYC-GVCT--------------DNRCCIPYKSKTIEVQFECPNGSMFSWPVMWINACF 334
Cdd:pfam00007   5 IPTNYTISvekeGCTSCKTINTTICaGYCYtrdpvykdgrravsQRVCTYRDVTYETVVLPGCPPGVDPTVTYPVALSCH 84

                          90
                  ....*....|..
gi 2565252596 335 CNLsCKNPNDIF 346
Cdd:pfam00007  85 CGN-CPTDNSDC 95
 
Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 209-252 2.83e-17

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 74.68  E-value: 2.83e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2565252596 209 CVSQTTPWSPCSKTCGTGLSMRVTNANDQCELVKERRLCNIRPC 252
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
IGFBP pfam00219
Insulin-like growth factor binding protein;
45-97 8.10e-10

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 53.87  E-value: 8.10e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2565252596  45 CKWPC---KCPKSPPRCSAGVslVMDGCDCCKACARQVGEKCNEAD-TCDyhKGLYC 97
Cdd:pfam00219   1 CPPPCdpeRCPPPPPGCPAGV--VLDGCGCCKVCARQEGEPCGVYTpPCG--KGLRC 53
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 48-105 7.17e-06

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 43.61  E-value: 7.17e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2565252596   48 PCKCPKSPPRCSAGVslVMDGCDCCKACARQVGEKCNeADTCDYHKGLYCDYSMDKPR 105
Cdd:smart00121   8 PARCPPCPPGCAELV--RLDGCGCCPVCARQEGEPCG-VYTPRCAPGLRCQPPPGEER 62
VWC smart00214
von Willebrand factor (vWF) type C domain;
119-177 7.23e-06

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 42.89  E-value: 7.23e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2565252596  119 CEDNGVIYRNGQSFQPNCKYKCMCVNGA-IGCVPVcrdSRPPLVWCQNPKRVKVPGKCCE 177
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPV---ECPPPPDCPNPERVKPPGECCP 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 119-178 4.34e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 40.87  E-value: 4.34e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2565252596 119 CEDNGVIYRNGQSFQPNCKYKCMCVNGAIGcvpvCRDSRPPLVWCQNPKRVKVPGKCCEQ 178
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVL----CDKIICPPLDCPNPRLEIPPGECCPV 56
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 210-252 1.26e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 39.18  E-value: 1.26e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2565252596 210 VSQTTPWSPCSKTCGTGLSMRV-------TNANDQCELVKERRLCNIRPC 252
Cdd:pfam19028   3 VSEWSEWSECSVTCGGGVQTRTrtvivepQNGGRPCPELLERRPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 210-253 1.20e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.41  E-value: 1.20e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2565252596  210 VSQTTPWSPCSKTCGTGLSMRVTNAND--------QC-ELVKERRLCNIRPCE 253
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpppqngggPCtGEDVETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 212-252 2.21e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 35.89  E-value: 2.21e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2565252596 212 QTTPWSPCSKTCGTGLSMRV----------TNANDQCELVK---ERRLCNIRPC 252
Cdd:pfam19030   2 VAGPWGECSVTCGGGVQTRLvqcvqkgggsIVPDSECSAQKkppETQSCNLKPC 55
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 275-339 3.04e-03

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 36.23  E-value: 3.04e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2565252596  275 PKNFTISGCiSKKTYRPKYC-GVCTD------------NRCCIPYKSKTIEVQFECPNGSMFSWPVMWINACFCNLSC 339
Cdd:smart00041   5 RQTITYNGC-TSVTVKNAFCeGKCGSassysiqdvqhsCSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEPNC 81
Cys_knot pfam00007
Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of ...
 274-346 3.57e-03

Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.


Pssm-ID: 394966  Cd Length: 105  Bit Score: 36.61  E-value: 3.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2565252596 274 EPKNFTIS----GCISKKTYRPKYC-GVCT--------------DNRCCIPYKSKTIEVQFECPNGSMFSWPVMWINACF 334
Cdd:pfam00007   5 IPTNYTISvekeGCTSCKTINTTICaGYCYtrdpvykdgrravsQRVCTYRDVTYETVVLPGCPPGVDPTVTYPVALSCH 84

                          90
                  ....*....|..
gi 2565252596 335 CNLsCKNPNDIF 346
Cdd:pfam00007  85 CGN-CPTDNSDC 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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