Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815675505 1003 LLDPVTANLFQRFVSLQGDLLGNGVLFWQEVQKYKDLCHSHCADAIVQKKITAIINCFINSAIPPALQIDIPPEQAKKIL 1082
Cdd:cd08725      1 LLNPVTSEQFQRFVSLKGEELENDLLFWLEVQKYKDLCHSHSDEHIIQNKITAIISCFIDSSVPPALQIDIPPEIANRIL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1815675505 1083 ERRKELGPYIFREAQMSVFALLFKFWPEFCKLQSNVDSEKIL 1124
Cdd:cd08725     81 EHRRELGPYIFREAQLTVFRVLFKYWAGFCEFRKNLQPEKIL 122

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815675505  832 LSDLIHDKEKLKQFWAFLNEHSAGMDLMCWLDIEEFRKMLHKDKERSEEKSKDIESKYFNDEYFFGPNSPATREQQEKLM 911
Cdd:cd08726      1 FQDLLHNRLELEFFRKFLEENSASMDLLCWLDIEQFRRIPHTDNAKRDEKAKEIKNKYLNKKYFFGPNSPATKEQQNKVM 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1815675505  912 HSGGGRRQILHDQLSAAVLLEVQQCVQKRLEKQWLPLFLADEHRGVEGQA 961
Cdd:cd08726     81 HAGGGWGKILHDRPPSSVLIEIQKIVRARLEKHWLPLFLATEQFRRRQAQ 130

Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815675505 1003 LLDPVTANLFQRFVSLQGDLLGNGVLFWQEVQKYKDLCHSHCADAIVQKKITAIINCFINSAIPPALQIDIPPEQAKKIL 1082
Cdd:cd08725      1 LLNPVTSEQFQRFVSLKGEELENDLLFWLEVQKYKDLCHSHSDEHIIQNKITAIISCFIDSSVPPALQIDIPPEIANRIL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1815675505 1083 ERRKELGPYIFREAQMSVFALLFKFWPEFCKLQSNVDSEKIL 1124
Cdd:cd08725     81 EHRRELGPYIFREAQLTVFRVLFKYWAGFCEFRKNLQPEKIL 122

Regulator of G protein signaling domain RGS_RGS22_3; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815675505  832 LSDLIHDKEKLKQFWAFLNEHSAGMDLMCWLDIEEFRKMLHKDKERSEEKSKDIESKYFNDEYFFGPNSPATREQQEKLM 911
Cdd:cd08726      1 FQDLLHNRLELEFFRKFLEENSASMDLLCWLDIEQFRRIPHTDNAKRDEKAKEIKNKYLNKKYFFGPNSPATKEQQNKVM 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1815675505  912 HSGGGRRQILHDQLSAAVLLEVQQCVQKRLEKQWLPLFLADEHRGVEGQA 961
Cdd:cd08726     81 HAGGGWGKILHDRPPSSVLIEIQKIVRARLEKHWLPLFLATEQFRRRQAQ 130

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815675505  999 FRKALLDPVTANLFQRFVSLQGDllGNGVLFWQEVQKYKDLCHshcaDAIVQKKITAIINCFINSAIPPalQIDIPPEQA 1078
Cdd:pfam00615    2 FDSLLEDQPGRRLFRQFLESEFS--EENLEFWLACEEFKKADP----DEERLKKAKEIYNEFLAPGSPK--EINLDSDLR 73

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1815675505 1079 KKILER-RKELGPYIFREAQMSVFALL-FKFWPEFCK 1113
Cdd:pfam00615   74 EEIRENlEKEPTRDLFDEAQAEVYELMeKDSYPRFLK 110

Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815675505 1003 LLDPVTANLFQRFVSLQGDLLGNGVLFWQEVQKYKDLCHSHCADAIVQKKITAIINCFINSAIPPALQIDIPPEQAKKIL 1082
Cdd:cd08725      1 LLNPVTSEQFQRFVSLKGEELENDLLFWLEVQKYKDLCHSHSDEHIIQNKITAIISCFIDSSVPPALQIDIPPEIANRIL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1815675505 1083 ERRKELGPYIFREAQMSVFALLFKFWPEFCKLQSNVDSEKIL 1124
Cdd:cd08725     81 EHRRELGPYIFREAQLTVFRVLFKYWAGFCEFRKNLQPEKIL 122

Regulator of G protein signaling domain RGS_RGS22_3; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815675505  832 LSDLIHDKEKLKQFWAFLNEHSAGMDLMCWLDIEEFRKMLHKDKERSEEKSKDIESKYFNDEYFFGPNSPATREQQEKLM 911
Cdd:cd08726      1 FQDLLHNRLELEFFRKFLEENSASMDLLCWLDIEQFRRIPHTDNAKRDEKAKEIKNKYLNKKYFFGPNSPATKEQQNKVM 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1815675505  912 HSGGGRRQILHDQLSAAVLLEVQQCVQKRLEKQWLPLFLADEHRGVEGQA 961
Cdd:cd08726     81 HAGGGWGKILHDRPPSSVLIEIQKIVRARLEKHWLPLFLATEQFRRRQAQ 130

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815675505 1003 LLDPVTANLFQRFVSLQGDLlgNGVLFWQEVQKYKDLCHShcaDAIVQKKITAIINCFINSAIPpaLQIDIPPEQAKKIL 1082
Cdd:cd07440      1 LRDPYGLEYFRQFLKSEHCE--ENLEFWLAVEKFKKTTSS---DEELKSKAKEIYDKYISKDAP--KEINIPESIREEIE 73

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1815675505 1083 ERRKELG--PYIFREAQMSVFALLFK-FWPEFCKLQ 1115
Cdd:cd07440     74 ENLEEPYpdPDCFDEAQEHILNLLEKdSYPRFLKSD 109

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815675505  836 IHDKEKLKQFWAFL-NEHSAgMDLMCWLDIEEFRKMLHKDKERsEEKSKDIESKYFNDEYFFGPNSPAtrEQQEKLMHSg 914
Cdd:cd07440      1 LRDPYGLEYFRQFLkSEHCE-ENLEFWLAVEKFKKTTSSDEEL-KSKAKEIYDKYISKDAPKEINIPE--SIREEIEEN- 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1815675505  915 ggrrqILHDQLSAAVLLEVQQCVQKRLEKQWLPLFLADEH 954
Cdd:cd07440     76 -----LEEPYPDPDCFDEAQEHILNLLEKDSYPRFLKSDL 110

Regulator of G protein signaling (RGS) domain found in the RGS10 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS10 protein. RGS10 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS10 belong to the R12 RGS subfamily, which includes RGS12 and RGS14, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS10 exists in 2 splice isoforms. RGS10A is specifically expressed in osteoclasts and is a key component in the RANKL signaling mechanism for osteoclast differentiation, whereas RGS10B expressed in brain and in immune tissues and has been implicated in diverse processes including: promoting of dopaminergic neuron survival via regulation of the microglial inflammatory response, modulation of presynaptic and postsynaptic G-protein signalling, as well as a possible role in regulation of gene expression.

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1815675505  832 LSDLIHDKEKLKQFWAFLNEHSAGMDLMCWLDIEEFRKMlhKDKERSEEKSKDIESKYFNDE 893
Cdd:cd08741      1 LENLLEDPEGVKRFREFLKKEFSEENVLFWLACEDFKKM--QDKTQMQEKAKEIYMTFLSSK 60