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Conserved domains on  [gi|1810995980|ref|XP_032353008|]
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LOW QUALITY PROTEIN: major facilitator superfamily domain-containing protein 2B [Camelus ferus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 41-482 0e+00

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17452:

Pssm-ID: 475125  Cd Length: 416  Bit Score: 657.66  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980  41 KVCYGIGGVPNQVASSAVAFYLQLFLLDVAQISAAQVSLVLFGGKVFGAAADPLAGFFINRSRRTGSGRLMPWVLGCMPF 120
Cdd:cd17452     1 KLCYAIGGAPNQVAGSATAFFLQIYLLDIAQITPFQASLVLFVGKAWGAATDPVVGFFISKSKWTKIGRLMPWMLGCTPF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 121 IALAYFFLWYLSPFTSLRGLWYMTFYCLFQALATFFQVPYTALIMLLTPNPRDRDSGTAYRMTMEMAGTLMGATIHGLIV 200
Cdd:cd17452    81 IVVSYFFLWFVPPFTTGRFLWYLTFYCLFQALATCFHVPYSALTMFLSTDQRERDSATAYRMTVEVLGTLVGAAVQGQIV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 201 SGAhgsqrceedtfpgqvavapsaarlYSTAAAVVAVTYPVCSGLLCLGVKERPDPSATASGQGLSFLSGLCLTVRHPPY 280
Cdd:cd17452   161 ASA------------------------YMIAAGVIGGLYLLCISVLFLGVKERDDPYAPKSGKAIPFFKGLSLTMRHGPY 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 281 LKLVISFLFISAAVQVEQSYLVLFCTHASRLHDHVQNLVLTILVSAVLSTPLWEWLLQRFGKRMSAFGICGIVPFAILLA 360
Cdd:cd17452   217 LKLTASFLFISAAVQLEQSNFVLFCTHAVDLHDHFQNLVLTILVSAVVSIPFWQWFLQRFGKKAAACGISWMIPFAIMLV 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 361 AVPTAPVAYVVAFVSGVSIAVSLLLPWSMLPDVVDDFQLqhQHQHGPGLETIFYSSYVFFTKLSGAGALGISTLSLDFAG 440
Cdd:cd17452   297 TIPNLIVAYVVAFVSGLSIAASLLLPWSMLPDVVDDFRL--QNPHGKGLETIFYSSYVFFTKLSAGIALGISTLSLEFAG 374

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 1810995980 441 YEAGACKQAEQVVVTLKVLIGAVPTCMILTGVCILMVGPTPK 482
Cdd:cd17452   375 YETGACKQPESVVLTLKLLIGAAPTCMILIGLCILMFYPITE 416
 
Name Accession Description Interval E-value
MFS_MFSD2B cd17452
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily ...
 41-482 0e+00

Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily domain-containing protein 2B (MFSD2B) is closely related to MFSD2A, and their conserved genomic structure suggests that they are derived from the duplication of an ancestral gene. Variations of chromosome 2 gene expressions among patients with lung cancer or non-cancer identified MFSD2B as a potential risk or protect factor in the prognosis of lung adenocarcinoma. MFSD2B belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341010  Cd Length: 416  Bit Score: 657.66  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980  41 KVCYGIGGVPNQVASSAVAFYLQLFLLDVAQISAAQVSLVLFGGKVFGAAADPLAGFFINRSRRTGSGRLMPWVLGCMPF 120
Cdd:cd17452     1 KLCYAIGGAPNQVAGSATAFFLQIYLLDIAQITPFQASLVLFVGKAWGAATDPVVGFFISKSKWTKIGRLMPWMLGCTPF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 121 IALAYFFLWYLSPFTSLRGLWYMTFYCLFQALATFFQVPYTALIMLLTPNPRDRDSGTAYRMTMEMAGTLMGATIHGLIV 200
Cdd:cd17452    81 IVVSYFFLWFVPPFTTGRFLWYLTFYCLFQALATCFHVPYSALTMFLSTDQRERDSATAYRMTVEVLGTLVGAAVQGQIV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 201 SGAhgsqrceedtfpgqvavapsaarlYSTAAAVVAVTYPVCSGLLCLGVKERPDPSATASGQGLSFLSGLCLTVRHPPY 280
Cdd:cd17452   161 ASA------------------------YMIAAGVIGGLYLLCISVLFLGVKERDDPYAPKSGKAIPFFKGLSLTMRHGPY 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 281 LKLVISFLFISAAVQVEQSYLVLFCTHASRLHDHVQNLVLTILVSAVLSTPLWEWLLQRFGKRMSAFGICGIVPFAILLA 360
Cdd:cd17452   217 LKLTASFLFISAAVQLEQSNFVLFCTHAVDLHDHFQNLVLTILVSAVVSIPFWQWFLQRFGKKAAACGISWMIPFAIMLV 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 361 AVPTAPVAYVVAFVSGVSIAVSLLLPWSMLPDVVDDFQLqhQHQHGPGLETIFYSSYVFFTKLSGAGALGISTLSLDFAG 440
Cdd:cd17452   297 TIPNLIVAYVVAFVSGLSIAASLLLPWSMLPDVVDDFRL--QNPHGKGLETIFYSSYVFFTKLSAGIALGISTLSLEFAG 374

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 1810995980 441 YEAGACKQAEQVVVTLKVLIGAVPTCMILTGVCILMVGPTPK 482
Cdd:cd17452   375 YETGACKQPESVVLTLKLLIGAAPTCMILIGLCILMFYPITE 416
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 43-476 5.16e-71

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 232.20  E-value: 5.16e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980  43 CYGIGGVPNQVASSAVAFYLQLFLLDVAQISAAQVSLVLFGGKVFGAAADPLAGFFINRSRrTGSGRLMPWVLGCMPFIA 122
Cdd:pfam13347   1 GYGSGALAAGIKYAGLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTR-TRWGRRRPWLLLSAIILA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 123 LAYFFLWYlSPFTSLRGL--WYMTFYCLFQALATFFQVPYTALIMLLTPNPRDRDSGTAYRMTMEMAGTLMGATIHGLIV 200
Cdd:pfam13347  80 VSFILLFT-PPELGRAPLfiWLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALAFPLV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 201 SGahgsqrceedtfpgqVAVAPSAARLYSTAAAVVAVTYPVCSGLLCLGVKERP---DPSATASGQGLSFLSGLCLTVRH 277
Cdd:pfam13347 159 LI---------------LGGTGLERKGYRIFALIGAVLMLLGVIITAAGTKERVsmrSKEDTGQKEAGSLLDMLKEVFRN 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 278 PPYLKLVISFLFISAAVQVEQSYLVLFCTHASRLHDHVQNLVLTILVSAVLSTPLWEWLLQRFGKRMSAFG--ICGIVPF 355
Cdd:pfam13347 224 RAFLILLASFLLAALAMGVLNGLLLYYFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILgaLITIAGF 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 356 AILLAAVPTAPVA-YVVAFVSGVSIAVSLLLPWSMLPDVVDDFQLqhqhQHGPGLETIFYSSYVFFTKLSGAGALGISTL 434
Cdd:pfam13347 304 ALALLLGPNNTLLfLVLYIIIGFGYGSSFFLPWSMLADVVDYGEL----RTGKRREGTFFAMWSFISKLATGVGLGVSGL 379

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 1810995980 435 SLDFAGYEAGACKQAEQVVVTLKVLIGAVPTCMILTGVCILM 476
Cdd:pfam13347 380 LLSAFGYNAGDSVQSPQAVTAIRLLYAVLPAVLFLVALLLLY 421
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
31-476 1.70e-69

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 229.02  E-value: 1.70e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980  31 SRAGRLSFCTKVCYGIGGVPNQVASSAVAFYLQLFLLDVAQISAAQVSLVLFGGKVFGAAADPLAGFFINRsRRTGSGRL 110
Cdd:COG2211     2 AAKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDR-TRTRWGRR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 111 MPWVLGCMPFIALAYFFLWYLSPFTSLRGLWYMT-FYCLFQALATFFQVPYTALIMLLTPNPRDRDSGTAYRMTMEMAGT 189
Cdd:COG2211    81 RPWILIGAIPLALSFVLLFTAPDLSPTGKLIYALvTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 190 LMGATIHGLIVsgahgsqrceeDTFPGQVAVApsaarlYSTAAAVVAVTYPVCSGLLCLGVKERPDPSAtasgQGLSFLS 269
Cdd:COG2211   161 LLASVLPPPLV-----------AAFGGDAALG------YRLTALIFAVLGLLAFLLTFFGTKERPVPEE----EKVSLKE 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 270 GLCLTVRHPPYLKLVISFLFISAAVQVEQSYLVLFCTHASRLHDHVQNLVLTIL-VSAVLSTPLWEWLLQRFGKR---MS 345
Cdd:COG2211   220 SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYfLAALLGAPLWPRLAKRFGKKkafII 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 346 AFGICGIVPFAILLAAVPTAPVAYVVAFVSGVSIAVSLLLPWSMLPDVVDDfqlqHQHQHGPGLETIFYSSYVFFTKLSG 425
Cdd:COG2211   300 GLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDY----DEWKTGRRREGLYFGIFTFAIKLGQ 375

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1810995980 426 AGALGISTLSLDFAGYEAGAcKQAEQVVVTLKVLIGAVPTCMILTGVCILM 476
Cdd:COG2211   376 ALAGALAGLLLALFGYVAGA-AQSPSALTGIRLLFFLLPAVLLLLAALLLL 425
PRK09669 PRK09669
putative symporter YagG; Provisional
 35-476 2.23e-18

putative symporter YagG; Provisional


Pssm-ID: 236610  Cd Length: 444  Bit Score: 87.47  E-value: 2.23e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980  35 RLSFCTKVCYGIGGVPNQVASSAVAFYLQLFLLDVAQISAAQVSLVLFGGKVFGAAADPLAGFFINRSRrTGSGRLMPWV 114
Cdd:PRK09669    5 QLTTKDKIGYGLGDTACNLVWQTVMLFLAYFYTDVFGLSAAIMGTMFLVVRVLDAVTDPLMGALVDRTR-TRHGQFRPYL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 115 L-GCMPF--IALAYFFLWYLSPFTSLrgLWYMTFYCLFQALATFFQVPYTALIMLLTPNPRDRDSGTAYRMTMemagtlm 191
Cdd:PRK09669   84 LwFAIPFgvVCLLTFYTPDFGATGKI--IYACVTYILLSLVYTAINVPYCAMPGAITNDPRERHSLQSWRFAL------- 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 192 gATIHGLIVSGAhgsqrceedTFPgQVAVAPS--AARLYSTAAAVVAVTYPVCSGLLCLGVKERPDPSATASGqglSFLS 269
Cdd:PRK09669  155 -SFIGGLIVSVI---------ALP-LVDILGKgdEQKGYFYAMMVMGLLGVVLFFCCFFMTKERYTPEVDNSS---SVWK 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 270 GLCLTVRHPPYLKLVISFLFISAAVQVEQSYLVLFCTHASRLHDHVQNLVLTILVSAVLSTPLWEWLLQRFgKRMSAFGI 349
Cdd:PRK09669  221 DLKLLLGNSQWRIMFIFNVVLLTAVVTRGGATLYYVNYVLLRPDLATLFLVTGMIAGLFGALLSERLLGKF-DRVRAFKW 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 350 CgIVPFAILLAA---VPTAPVAYVVAFVSGVSIAVSLLLP--WSMLPDVVDdfqlQHQHQHGPGLETIFYSSYVFFTKLS 424
Cdd:PRK09669  300 T-IVAFVILSALiffIPPSNVWLIFALNILFNFIQNLTTPlqWSMFSDVVD----YEEKRSGRRLDGLVFSTNLFAIKLG 374

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1810995980 425 GAGALGISTLSLDFAGYEAGACKQAEQVVVTLKVLIGAVPtCMILTGVCILM 476
Cdd:PRK09669  375 LAIGGAVVGWILAWVDYVGGAAVQSASVLTTINLLFTVIP-GVLFAGMAIIL 425
 
Name Accession Description Interval E-value
MFS_MFSD2B cd17452
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily ...
 41-482 0e+00

Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily domain-containing protein 2B (MFSD2B) is closely related to MFSD2A, and their conserved genomic structure suggests that they are derived from the duplication of an ancestral gene. Variations of chromosome 2 gene expressions among patients with lung cancer or non-cancer identified MFSD2B as a potential risk or protect factor in the prognosis of lung adenocarcinoma. MFSD2B belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341010  Cd Length: 416  Bit Score: 657.66  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980  41 KVCYGIGGVPNQVASSAVAFYLQLFLLDVAQISAAQVSLVLFGGKVFGAAADPLAGFFINRSRRTGSGRLMPWVLGCMPF 120
Cdd:cd17452     1 KLCYAIGGAPNQVAGSATAFFLQIYLLDIAQITPFQASLVLFVGKAWGAATDPVVGFFISKSKWTKIGRLMPWMLGCTPF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 121 IALAYFFLWYLSPFTSLRGLWYMTFYCLFQALATFFQVPYTALIMLLTPNPRDRDSGTAYRMTMEMAGTLMGATIHGLIV 200
Cdd:cd17452    81 IVVSYFFLWFVPPFTTGRFLWYLTFYCLFQALATCFHVPYSALTMFLSTDQRERDSATAYRMTVEVLGTLVGAAVQGQIV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 201 SGAhgsqrceedtfpgqvavapsaarlYSTAAAVVAVTYPVCSGLLCLGVKERPDPSATASGQGLSFLSGLCLTVRHPPY 280
Cdd:cd17452   161 ASA------------------------YMIAAGVIGGLYLLCISVLFLGVKERDDPYAPKSGKAIPFFKGLSLTMRHGPY 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 281 LKLVISFLFISAAVQVEQSYLVLFCTHASRLHDHVQNLVLTILVSAVLSTPLWEWLLQRFGKRMSAFGICGIVPFAILLA 360
Cdd:cd17452   217 LKLTASFLFISAAVQLEQSNFVLFCTHAVDLHDHFQNLVLTILVSAVVSIPFWQWFLQRFGKKAAACGISWMIPFAIMLV 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 361 AVPTAPVAYVVAFVSGVSIAVSLLLPWSMLPDVVDDFQLqhQHQHGPGLETIFYSSYVFFTKLSGAGALGISTLSLDFAG 440
Cdd:cd17452   297 TIPNLIVAYVVAFVSGLSIAASLLLPWSMLPDVVDDFRL--QNPHGKGLETIFYSSYVFFTKLSAGIALGISTLSLEFAG 374

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 1810995980 441 YEAGACKQAEQVVVTLKVLIGAVPTCMILTGVCILMVGPTPK 482
Cdd:cd17452   375 YETGACKQPESVVLTLKLLIGAAPTCMILIGLCILMFYPITE 416
MFS_MFSD2 cd17392
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator ...
 41-482 0e+00

Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator superfamily domain-containing protein 2 (MFSD2) subfamily is composed of two vertebrate members, MFSD2A amd MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD2 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340950  Cd Length: 446  Bit Score: 628.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980  41 KVCYGIGGVPNQVASSAVAFYLQLFLLDVAQISAAQVSLVLFGGKVFGAAADPLAGFFINRSRRTGSGRLMPWVLGCMPF 120
Cdd:cd17392     1 KLCYAIGGAPYQMTSSATGFFLQIFLLDVAQMGAFSVSLILFVGRVWDAVTDPLVGYFISRSQRTGIGRLMPWIVFSTPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 121 IALAYFFLWYLSPFTSLRGLWYMTFYCLFQALATFFQVPYTALIMLLTPNPRDRDSGTAYRMTMEMAGTLMGATIHGLIV 200
Cdd:cd17392    81 IILAYFFLWFLPPFTSLSGLWYLTFYCLFETFMTCFHVPYSALTMFLGGCQRERDSATAYRMTVEVFGTLMGATIQGQIV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 201 SGAHGSQRCE----EDTFPGQVAVAPSAARLYSTAAAVVAVTYPVCSGLLCLGVKERPDPSATASGQGLSFLSGLCLTVR 276
Cdd:cd17392   161 GVAHRPRRQDctatPGTSDHPVTVLPNTRRAYLIAALVVVVLYFVCCSILFLGVKEQPDPLSPASGPGLSYLAGLKLVTG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 277 HPPYLKLVISFLFISAAVQVEQSYLVLFCTHASRLHDHVQNLVLTILVSAVLSTPLWEWLLQRFGKR-MSAFGICGIVPF 355
Cdd:cd17392   241 HPPYLKLVIGFLFSSLAFQMEQGNFVLFCTHAAGLGDHFQHLVLAILVSATLSIPLWQWVLQRRGKKtTSFIGISAMVPF 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 356 AILLAAVP-TAPVAYVVAFVSGVSIAVSLLLPWSMLPDVVDDFQLqhQHQHGPGLETIFYSSYVFFTKLSGAGALGISTL 434
Cdd:cd17392   321 LILLALVPsNLPVAYVVAVVSGVSLAALFLLPWSMLPDVVDDFQL--KNPHCPGLEPIFYSCYVFFTKLGGGLSLGISTL 398

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 1810995980 435 SLDFAGYEAGACKQAEQVVVTLKVLIGAVPTCMILTGVCILMVGPTPK 482
Cdd:cd17392   399 SLHFSGYKAGACKQPEEVVVTLKVLIAPVPICLILAGLVLFYVYPINE 446
MFS_NLS1_MFSD2A cd17451
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of ...
 41-479 5.90e-133

Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of transporters; Sodium-dependent lysophosphatidylcholine (LPC) symporter 1 (NLS1) is also called major facilitator superfamily domain-containing protein 2A (MFSD2A). NLS1/MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. It also transports the essential omega-3 fatty acid docosahexaenoic acid (DHA), which is essential for normal brain growth and cognitive function, in the form of LPC into the brain across the blood-brain barrier. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. NLS1/MFSD2A belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341009  Cd Length: 419  Bit Score: 391.48  E-value: 5.90e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980  41 KVCYGIGGVPNQVASSAVAFYLQLFLLDVAQISAAQVSLVLFGGKVFGAAADPLAGFFINRSRRTGSGRLMPWVLGCMPF 120
Cdd:cd17451     1 KLCYAIGGAPYQITGCALGFFLQIYLLDVAQLDPFYASIILFVGRAWDAITDPTVGFFVSKSPWTRFGRLMPWIIFSTPF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 121 IALAYFFLWYLSPFTSLRGLWYMTFYCLFQALATFFQVPYTALIMLLTPNPRDRDSGTAYRMTMEMAGTLMGATIHGLIV 200
Cdd:cd17451    81 AVLSYFLIWFVPDFSQGKVMWYLLFYCLFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMTVEVLGTVLGTAIQGQIV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 201 sgahgsqrceedtfpGQVAvapsaarlYSTAAAVVAVTYPVCSGLLCLGVKERPDPSATASGQGLSFLSGLCLTVRHPPY 280
Cdd:cd17451   161 ---------------GMAA--------YMIAAGVICAIYVLCAIILFLGVREQREPCELKSQKPVSFFKGLKLVMSHGPY 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 281 LKLVISFLFISAAVQVEQSYLVLFCTHASRLHDHVQNLVLTILVSAVLSTPLWEWLLQRFGKRMSA-FGICGIVPFAILL 359
Cdd:cd17451   218 IKLITGFLFTSLAFMLLEGNFALFCTYTLGFRNDFQNILLVIMLSATLTIPFWQWFLTRFGKKTAVyIGISSAVPFLILV 297

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 360 AAVPTA-PVAYVVAFVSGVSIAVSLLLPWSMLPDVVDDFQLQHQHQHGPglETIFYSSYVFFTKLSGAGALGISTLSLDF 438
Cdd:cd17451   298 VLVESNlIVTYVVSVAAGVSVAAAFLLPWSMLPDVVDDFKLKNPDSQGH--EAIFYSFYVFFTKFASGVSLGISTLSLDF 375

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1810995980 439 AGYEAGACKQAEQVVVTLKVLIGAVPTCMILTGVCILMVGP 479
Cdd:cd17451   376 AGYQTRGCSQPEEVNLTLKMLVSAAPVVLILLGLLLFKLYP 416
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 41-482 3.38e-73

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 237.89  E-value: 3.38e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980  41 KVCYGIGGVPNQVASSAVAFYLQLFLLDVAQISAAQVSLVLFGGKVFGAAADPLAGFFINRsRRTGSGRLMPWVLGCMPF 120
Cdd:cd17332     1 KIGYGLGDFGNNLIFQIVSTYLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDR-TRSRWGRFRPWLLWGAIP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 121 IALAYFFLWYlSPFTSLRGL--WYMTFYCLFQALATFFQVPYTALIMLLTPNPRDRDSGTAYRMTMEMAGTLMGATIHGL 198
Cdd:cd17332    80 LALLFVLLFT-TPDGSGTGKliYALITYILLDLLYTLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTVLPPP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 199 IVSGAHGsqrceedtfpgqvavaPSAARLYSTAAAVVAVTYPVCSGLLCLGVKERPDPSATASgQGLSFLSGLCLTVRHP 278
Cdd:cd17332   159 LVAYFGG----------------GNASRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEK-SKLPLLKSLKALLKNR 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 279 PYLKLVISFLFISAAVQVEQSYLVLFCTHASRLHDHVQNLVLTILVSAVLSTPLWEWLLQRFGKRMSAFGICGIVPFAIL 358
Cdd:cd17332   222 PFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLL 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 359 LAAVPTA---PVAYVVAFVSGVSIAVSLLLPWSMLPDVVDDFQLQHQHQhgpgLETIFYSSYVFFTKLSGAGALGISTLS 435
Cdd:cd17332   302 LLFFLPPgnlVLILVLAVLAGIGYGGANLLPWAMLADVIDYGELKTGKR----REGIFYSVMTFFRKLGLALAGALVGLI 377

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 1810995980 436 LDFAGYEAGACKQAEQVVVTLKVLIGAVPTCMILTGVCILMVGPTPK 482
Cdd:cd17332   378 LSLAGYVANAAAQSASALNGIRLLIAVLPAVLLLLALILMSFYPLDK 424
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 43-476 5.16e-71

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 232.20  E-value: 5.16e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980  43 CYGIGGVPNQVASSAVAFYLQLFLLDVAQISAAQVSLVLFGGKVFGAAADPLAGFFINRSRrTGSGRLMPWVLGCMPFIA 122
Cdd:pfam13347   1 GYGSGALAAGIKYAGLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTR-TRWGRRRPWLLLSAIILA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 123 LAYFFLWYlSPFTSLRGL--WYMTFYCLFQALATFFQVPYTALIMLLTPNPRDRDSGTAYRMTMEMAGTLMGATIHGLIV 200
Cdd:pfam13347  80 VSFILLFT-PPELGRAPLfiWLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALAFPLV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 201 SGahgsqrceedtfpgqVAVAPSAARLYSTAAAVVAVTYPVCSGLLCLGVKERP---DPSATASGQGLSFLSGLCLTVRH 277
Cdd:pfam13347 159 LI---------------LGGTGLERKGYRIFALIGAVLMLLGVIITAAGTKERVsmrSKEDTGQKEAGSLLDMLKEVFRN 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 278 PPYLKLVISFLFISAAVQVEQSYLVLFCTHASRLHDHVQNLVLTILVSAVLSTPLWEWLLQRFGKRMSAFG--ICGIVPF 355
Cdd:pfam13347 224 RAFLILLASFLLAALAMGVLNGLLLYYFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILgaLITIAGF 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 356 AILLAAVPTAPVA-YVVAFVSGVSIAVSLLLPWSMLPDVVDDFQLqhqhQHGPGLETIFYSSYVFFTKLSGAGALGISTL 434
Cdd:pfam13347 304 ALALLLGPNNTLLfLVLYIIIGFGYGSSFFLPWSMLADVVDYGEL----RTGKRREGTFFAMWSFISKLATGVGLGVSGL 379

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 1810995980 435 SLDFAGYEAGACKQAEQVVVTLKVLIGAVPTCMILTGVCILM 476
Cdd:pfam13347 380 LLSAFGYNAGDSVQSPQAVTAIRLLYAVLPAVLFLVALLLLY 421
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
31-476 1.70e-69

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 229.02  E-value: 1.70e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980  31 SRAGRLSFCTKVCYGIGGVPNQVASSAVAFYLQLFLLDVAQISAAQVSLVLFGGKVFGAAADPLAGFFINRsRRTGSGRL 110
Cdd:COG2211     2 AAKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDR-TRTRWGRR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 111 MPWVLGCMPFIALAYFFLWYLSPFTSLRGLWYMT-FYCLFQALATFFQVPYTALIMLLTPNPRDRDSGTAYRMTMEMAGT 189
Cdd:COG2211    81 RPWILIGAIPLALSFVLLFTAPDLSPTGKLIYALvTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 190 LMGATIHGLIVsgahgsqrceeDTFPGQVAVApsaarlYSTAAAVVAVTYPVCSGLLCLGVKERPDPSAtasgQGLSFLS 269
Cdd:COG2211   161 LLASVLPPPLV-----------AAFGGDAALG------YRLTALIFAVLGLLAFLLTFFGTKERPVPEE----EKVSLKE 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 270 GLCLTVRHPPYLKLVISFLFISAAVQVEQSYLVLFCTHASRLHDHVQNLVLTIL-VSAVLSTPLWEWLLQRFGKR---MS 345
Cdd:COG2211   220 SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYfLAALLGAPLWPRLAKRFGKKkafII 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 346 AFGICGIVPFAILLAAVPTAPVAYVVAFVSGVSIAVSLLLPWSMLPDVVDDfqlqHQHQHGPGLETIFYSSYVFFTKLSG 425
Cdd:COG2211   300 GLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDY----DEWKTGRRREGLYFGIFTFAIKLGQ 375

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1810995980 426 AGALGISTLSLDFAGYEAGAcKQAEQVVVTLKVLIGAVPTCMILTGVCILM 476
Cdd:COG2211   376 ALAGALAGLLLALFGYVAGA-AQSPSALTGIRLLFFLLPAVLLLLAALLLL 425
PRK09669 PRK09669
putative symporter YagG; Provisional
 35-476 2.23e-18

putative symporter YagG; Provisional


Pssm-ID: 236610  Cd Length: 444  Bit Score: 87.47  E-value: 2.23e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980  35 RLSFCTKVCYGIGGVPNQVASSAVAFYLQLFLLDVAQISAAQVSLVLFGGKVFGAAADPLAGFFINRSRrTGSGRLMPWV 114
Cdd:PRK09669    5 QLTTKDKIGYGLGDTACNLVWQTVMLFLAYFYTDVFGLSAAIMGTMFLVVRVLDAVTDPLMGALVDRTR-TRHGQFRPYL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 115 L-GCMPF--IALAYFFLWYLSPFTSLrgLWYMTFYCLFQALATFFQVPYTALIMLLTPNPRDRDSGTAYRMTMemagtlm 191
Cdd:PRK09669   84 LwFAIPFgvVCLLTFYTPDFGATGKI--IYACVTYILLSLVYTAINVPYCAMPGAITNDPRERHSLQSWRFAL------- 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 192 gATIHGLIVSGAhgsqrceedTFPgQVAVAPS--AARLYSTAAAVVAVTYPVCSGLLCLGVKERPDPSATASGqglSFLS 269
Cdd:PRK09669  155 -SFIGGLIVSVI---------ALP-LVDILGKgdEQKGYFYAMMVMGLLGVVLFFCCFFMTKERYTPEVDNSS---SVWK 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 270 GLCLTVRHPPYLKLVISFLFISAAVQVEQSYLVLFCTHASRLHDHVQNLVLTILVSAVLSTPLWEWLLQRFgKRMSAFGI 349
Cdd:PRK09669  221 DLKLLLGNSQWRIMFIFNVVLLTAVVTRGGATLYYVNYVLLRPDLATLFLVTGMIAGLFGALLSERLLGKF-DRVRAFKW 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 350 CgIVPFAILLAA---VPTAPVAYVVAFVSGVSIAVSLLLP--WSMLPDVVDdfqlQHQHQHGPGLETIFYSSYVFFTKLS 424
Cdd:PRK09669  300 T-IVAFVILSALiffIPPSNVWLIFALNILFNFIQNLTTPlqWSMFSDVVD----YEEKRSGRRLDGLVFSTNLFAIKLG 374

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1810995980 425 GAGALGISTLSLDFAGYEAGACKQAEQVVVTLKVLIGAVPtCMILTGVCILM 476
Cdd:PRK09669  375 LAIGGAVVGWILAWVDYVGGAAVQSASVLTTINLLFTVIP-GVLFAGMAIIL 425
MFS_MFSD12 cd17491
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily ...
 41-434 2.45e-15

Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily domain-containing protein 12 (MFSD12) protein subfamily includes a group of uncharacterized proteins similar to human MFSD2. MFSD2 is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD12 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341044  Cd Length: 438  Bit Score: 78.07  E-value: 2.45e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980  41 KVCYGIGGVPNQVASSAVAFYLQLFLLDVAQISAAQVSLVLFGGKVFGAAADPLAGFFINRSRRTGS-GRLMPW-VLG-- 116
Cdd:cd17491     1 RIAYGVGHVLNDLCASMWFTYLLVYFHLVLGFSSALAGILLLIGQVADAISTPLVGYESDRTNGCGKyGRRKSWhLIGti 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 117 CMpfiALAYFFLWYLSPFTS------LRGLWYMTFYCLFQALATFFQVPYTALIMLLTPNPRDRDSGTAYRMTMEMAgtl 190
Cdd:cd17491    81 CV---LLSFPFIFNPCLGCSdstsewAKLVYYGPFIIIFQFGWAAVQISHLSLIPELTSDEHERVELTALRYAFTVI--- 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 191 mgATIHGLIVSGAHGSQRCEEDTFPGQVAVAPSAARLystaAAVVAVTYPVCSGLLCLGVKERPDP----SATASGQGLS 266
Cdd:cd17491   155 --ANITVYLIAWLLLQQSSGDSVNPTSAQDLPIFRNL----SLIVVGIGFLFSLLFHLGTKEPRPPtdlsTTTNEGEEVT 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 267 FLSGLCLTVRHppYLKLV----ISFLFISA--AVQVEQSYLVLFCTHASRLH-DHVQNLVLTILVSAVLSTPLWEWLLQR 339
Cdd:cd17491   229 APEEPRLTWKE--WLREPqfyqVALLYMCTrlIVNLSQVYIPLYLTETLQLPkESIAIVPLVMYVSGFLTSLVMKPINKK 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 340 FGKRMS-----AFGICGIVPFAILLAAVPTAPVaYVVAFVSGVSIAVSLLLPWSMLPDVVddfqlqhqhqhGPGLET--I 412
Cdd:cd17491   307 IGRKITyllglLFVLGFCIWVWFQSGSSRTYEI-YGAAVLLGVGSATLLVTSLSMTADLI-----------GTNTESgaF 374

                         410       420
                  ....*....|....*....|...
gi 1810995980 413 FYSSYVFFTKLS-GAGALGISTL 434
Cdd:cd17491   375 VYGAMSFTDKLSnGIAVLIIQSL 397
PRK09848 PRK09848
glucuronide transporter; Provisional
 36-479 1.43e-14

glucuronide transporter; Provisional


Pssm-ID: 182109 [Multi-domain]  Cd Length: 448  Bit Score: 75.59  E-value: 1.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980  36 LSFCTKVCYGIGGVPNQVASSAVAFYLQLFLLDVAQISAAQVSLVLFGGKVFGAAADPLAGFFINRSrRTGSGRLMPWVL 115
Cdd:PRK09848    5 LSWRTIVGYSLGDVANNFAFAMGALFLLSYYTDVAGVGAAAAGTMLLLVRVFDAFADVFAGRVVDSV-NTRWGKFRPFLL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 116 -GCMPFIALAYFFLWYLSPFTSLRGLWYMtfYCLFQALAT---FFQVPYTALIMLLTPNPRDRDSGTAYRMTM-EMAGTL 190
Cdd:PRK09848   84 fGTAPLMIFSVLVFWVPTDWSHSSKVVYA--YLTYMGLGLcysLVNIPYGSLATAMTQQPQSRARLGAARGIAaSLTFVC 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 191 MGATIHGLIVSGAHGSQRCEEDTFPGQVAVAPSAARLYSTAAAVVAVtypvcsgllclgVKERPDPSATASGQGLSflsg 270
Cdd:PRK09848  162 LAFLIGPSIKNSSPEEMVSVYHFWTIVLAIAGMVLYFICFKSTRENV------------VRIVAQPSLKISLQTLK---- 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 271 lcltvRHPPYLKL-VISFLFISAAVQVEQSYLVLFCTHASRLHDHVQNLVLTILVSAVLSTPLWEWLLQRFGKRM----- 344
Cdd:PRK09848  226 -----RNRPLFMLcIGALCVLISTFAVSASSLFYVRYVLNDTGLFTVLVLVQNLVGTVASAPLVPGMVARIGKKNtflig 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 345 SAFGICGIVPFaiLLAAVPTAPVAYVVAFVSGVSIAVSLLLPWSMLPDVVDdfqlQHQHQHGPGLETIFYSSYVFFTKLS 424
Cdd:PRK09848  301 ALLGTCGYLLF--FWVSVWSLPVALVALAIASIGQGVTMTVMWALEADTVE----YGEYLTGVRIEGLTYSLFSFTRKCG 374

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1810995980 425 GAGALGISTLSLDFAGYEAGACkQAEQVVVTLKVLIGAVPTCMILTGVCILMVGP 479
Cdd:PRK09848  375 QAIGGSIPAFILGLSGYIANQV-QTPEVIMGIRTSIALVPCGFMLLAFVIIWFYP 428
PRK11462 PRK11462
putative transporter; Provisional
 36-472 7.48e-14

putative transporter; Provisional


Pssm-ID: 183145  Cd Length: 460  Bit Score: 73.43  E-value: 7.48e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980  36 LSFCTKVCYGIGGVPNQVASSAVAFYLQLFLLDVAQISAAQVSLVLFGGKVFGAAADPLAGFFINRSrRTGSGRLMPWVL 115
Cdd:PRK11462    6 LSVKEKIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRT-RSRWGKFRPWVL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 116 -GCMPFIALAyfFLWYLSPFTSLRG--LWYMTFYCLFQALATFFQVPYTALIMLLTPNPRDRDSGTAYRMTMEMAGTLMG 192
Cdd:PRK11462   85 fGALPFGIVC--VLAYSTPDLSMNGkmIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVLATAGGMLS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 193 ATIHGLIVSGAHGSQRCEedTFPGQVAVapsaarLYSTAAAVVAVTYpvcsgllcLGVKERPD-PSATASGQG------- 264
Cdd:PRK11462  163 TVLMMPLVNLIGGDNKPL--GFQGGIAV------LSVVAFMMLAFCF--------FTTKERVEaPPTTTSMREdlrdiwq 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 265 ---------LSFLSGLCLTVRHPPYLKLVIsflFISAAVQVEQSYLVLFCthasrlhdhVQNlvltiLVSAVLSTPLWEW 335
Cdd:PRK11462  227 ndqwrivglLTIFNILAVCVRGGAMMYYVT---WILGTPEVFVAFLTTYC---------VGN-----LIGSALAKPLTDW 289

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 336 LLqrfgkRMSAF----GICGIVPFAILLAAVPTAPVAYVVAFVSGVSIAVSLLLPWSMLPDVVDdfqlQHQHQHGPGLET 411
Cdd:PRK11462  290 KC-----KVTIFwwtnALLAVISLAMFFVPMQASITMFVFIFVIGVLHQLVTPIQWVMMSDTVD----YGEWCNGKRLTG 360

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1810995980 412 IFYSSYVFFTKLSGAGALGISTLSLDFAGYEAGACKQAEQVVVTLKVLIGAVPT-CMILTGV 472
Cdd:PRK11462  361 ISFAGTLFVLKLGLAFGGALIGWMLAYGGYDAAEKAQNSATISIIIALFTIVPAiCYLLSAI 422
PRK10429 PRK10429
melibiose:sodium transporter MelB;
34-468 3.44e-12

melibiose:sodium transporter MelB;


Pssm-ID: 182453  Cd Length: 473  Bit Score: 68.58  E-value: 3.44e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980  34 GRLSFCTKVCYGIGGVPNQVASSAVAFYLQLFLLDVAQISAAQVSLVLFGGKVFGAAADPLAGFFINRSrRTGSGRLMPW 113
Cdd:PRK10429    1 MSISMTTKLSYGFGAFGKDFAIGIVYMYLMYYYTDVVGLSVGLVGTLFLVARIWDAINDPIMGWIVNNT-RSRWGKFKPW 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 114 VLGCMPFIALAYFFL---WYLSPFTSLRGLWYMtfYCLFQALATFFQVPYTALIMLLTPNPRDRDSGTAY-RMTMEMAGT 189
Cdd:PRK10429   80 ILIGTLANSVVLFLLfsaHLFEGTAQYVFVCVT--YILWGMTYTIMDIPFWSLVPTLTLDKREREQLVPYpRFFASLAGF 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 190 LMGATIHGLIVSGAHGSQRCEEDTFpgqvavapsaarlystaAAVVAVTYPVCSGLLCLGVKER--PDPSATASGQGLSF 267
Cdd:PRK10429  158 VTAGFTLPFVNYVGGGDRGFGFQMF-----------------TLVLIAFFIVSTIITLRNVHEVysSDNQVSAEGSHLTL 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 268 LSGLCLTVRHPPYLKLVISFLFISAAVQVEQSYLVLFCTHASRLHDHVQNLVLTILVSAVLSTPLWEWLLQRFGKRMSAF 347
Cdd:PRK10429  221 KDIVALIYKNDQLSCLLGMALAYNIASNIINGFAIYYFTYVIGDADLFPYYLSYAGAANLVTLILFPRLVKSLSRRILWA 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 348 GICG--IVPFAILLAAVPTAPVAYVVAFVSGVSIAVSLLLPWS----MLPDVVDdfqlQHQHQHGPGLETIFYSSYVFFT 421
Cdd:PRK10429  301 GASIfpVLSCGVLLLMGLAAPHNALLIVIAGILLNIGTALFWVlqviMVADTVD----YGEYKLGIRCESIAYSVQTMVV 376

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 1810995980 422 KLSGAGALGISTLSLDFAGYEAGAcKQAEQVVVTLKVLIGAVPTCMI 468
Cdd:PRK10429  377 KGGSAFAAFFIGVVLGLIGYVPNV-EQSAQTLLGMQFIMIGLPTLFF 422
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 42-431 4.62e-08

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 55.33  E-value: 4.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980  42 VCYGIGGVpnQVASSAVAFYLQLFLLDVAqISAAQVSLVLFggkvfgaaADPLAGFFI-----NRSRRTGS--GRLMPWV 114
Cdd:cd17313     4 LGFGFFGI--EFGWALENSYVPPILQTLG-LSHALIGFVWT--------LGPILGLFVqplvgSLSDRCNSriGRRRPFI 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 115 LGCMPFIALAYFFL----WYLSPFTSLRGLWYMTFYCLFQAL----ATFFQVPYTALIMLLTPnPRDRDsgTAYRMTMEM 186
Cdd:cd17313    73 LVGAPLAALGLILIpnaaDIGLALGDGPRTWALVLFVLGIVLldfaMNVCQGPVRALLPDLVP-PEQRS--KANGIINFM 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 187 AGtlMGATIhGLIVSGAHGSQRCEEDTFPGQVAVApsaarlystaAAVVAVTYPVCSGLLCLGVKERPD----PSATASG 262
Cdd:cd17313   150 GG--LGGVL-GYLLGAILWDHNWFGFALGGNLKVP----------FYIGAIILLVCVLVTLFFVKEPPLspeaGEHSENP 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 263 QGLSFLSGLCLTVRH--PPYLKLVISFLFISAAVQVEQSYLVLFCTHASRLHDHVQNLVLTI-------------LVSAV 327
Cdd:cd17313   217 SLGEVLKSLLKLLKImpRSLLRLLLVIFFWWIAFFPFELFFTDYMGEEVYHGTSAASSHYGAgvrmgawgllifsLAFLI 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 328 LSTPLwEWLLQRFGKR-MSAFGICGIVPFAILLAAVPTAPVAYVVAFVSGVSIAVSLLLPWSMLPDVVDDfqlqhqHQHG 406
Cdd:cd17313   297 FSLPI-GKLGKKIGRKkVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHSE------SGRG 369

                         410       420
                  ....*....|....*....|....*
gi 1810995980 407 PGLETIFYSSYVFFTKLSGAGALGI 431
Cdd:cd17313   370 QGTDTGLLNLAISLAQILVSLLAGP 394
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 52-383 2.15e-06

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 49.92  E-value: 2.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980  52 QVASSAVAFYLQLFLLDVAQiSAAQVSLVLFGGKVFGAAADPLAGFFINRSRRtgsGRLMPWVLGCMpFIALAYFFLWYL 131
Cdd:cd06173    12 ALGDWIFTVALPWLVLQLTG-SALLVGLVLAAFFLPFLLFSPFAGVLADRFDR---RRLLILADLLR-ALLAAVLALLAL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 132 SPFTSLRGLWYMTFycLFQALATFFQVPYTALIMLLTPnPRDRDSGTAYRMTMEMAGTLMGATIHGLIVSGAHGsqrcee 211
Cdd:cd06173    87 LGSLSLWLLLVLAF--LLGIASAFFGPARQALLPELVP-KEQLVRANALNSLATQLARIIGPALGGLLVALLGP------ 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 212 dtfpgqvavapsaarlySTAAAVVAVTYpVCSGLLCLGVKERPDPSATASGQGL--SFLSGLCLTVRHPPYLKLVISFLF 289
Cdd:cd06173   158 -----------------GGAFAINALSF-LLSALLLLFIRRPPPAAPGESSSLLlrDLREGLRYLRRSPLLRLLLLALAL 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 290 ISAAVQVEQSYLVLFCTHASRLHDHVQNLVLTIL-VSAVLSTPLWEWLLQRFGK-RMSAFGICGIVPFAILLAAVPTAPV 367
Cdd:cd06173   220 FALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFgVGALLGALLLGRLSKRRRRgRLLLIGALLLGLALLVLGLSPSLWL 299

                         330
                  ....*....|....*.
gi 1810995980 368 AYVVAFVSGVSIAVSL 383
Cdd:cd06173   300 LLAALFLLGLAGGLFN 315
MFS_1 pfam07690
Major Facilitator Superfamily;
46-394 1.08e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 44.33  E-value: 1.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980  46 IGGVPNQVASSAVAFYLQLFLLDVAQISAAQVSLVLFGGKVFGAAADPLAGFFINRSRRTgsgrlmPWVLGCMPFIALAY 125
Cdd:pfam07690   3 LAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRR------RVLLIGLLLFALGL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 126 FFLWYLSPFTSLrglwyMTFYCLFQALATFFQVPYTALIMLLTPnPRDRDSGTAYRMTMEMAGTLMGATIHGLIVSGAHg 205
Cdd:pfam07690  77 LLLLFASSLWLL-----LVLRVLQGLGAGALFPAALALIADWFP-PEERGRALGLVSAGFGLGAALGPLLGGLLASLFG- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 206 sqrceedtfpgqvavapsaarlYSTAAAVVAVTYPVCSGLLCLGVKERPDPSATASGQGLSFLSGLCLTVRHPPYLKLVI 285
Cdd:pfam07690 150 ----------------------WRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLL 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 286 SFLFISAAVQVEQSYLVLFCTHASrlHDHVQNLVLTILVSAV--LSTPLWEWLLQRFGKR---MSAFGICGIVPFAILLA 360
Cdd:pfam07690 208 ALLLFGFAFFGLLTYLPLYQEVLG--LSALLAGLLLGLGGLLgaIGRLLLGRLSDRLGRRrrlLLALLLLILAALGLLLL 285

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1810995980 361 AVP-TAPVAYVVAFVSGVSIAVSLLLPWSMLPDVV 394
Cdd:pfam07690 286 SLTlSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
72-396 1.56e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 43.81  E-value: 1.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980  72 ISAAQVSLVLFGGKVFGAAADPLAGFFinrSRRTGSGRLMPWVLGCMPFIALAYFFLWylspftslrGLWYMTFYCLFQA 151
Cdd:COG2814    42 ASPAQAGLVVTAYLLGAALGAPLAGRL---ADRFGRRRVLLLGLLLFALGSLLCALAP---------SLWLLLAARFLQG 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 152 LAT-FFQVPYTALIMLLTPnPRDRDSGTAYRMTMEMAGTLMGATIHGLIVSGAHgsqrceedtfpgqvavapsaarlYST 230
Cdd:COG2814   110 LGAgALFPAALALIADLVP-PERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-----------------------WRW 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 231 AAAVVAVTYPVCSGLLCLGVKERPDPSATASGQGLSFLsglcltVRHPPYLKLVISFLFISAAVQVEQSYLVLFCTHASR 310
Cdd:COG2814   166 VFLVNAVLALLALLLLLRLLPESRPAARARLRGSLREL------LRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLG 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 311 LHDHVQNLVLTIL-VSAVLSTPLWEWLLQRFG-KRMSAFGICGIVPFAILLAAVPTAPVAYVVAFVSGVSIAVSLLLPWS 388
Cdd:COG2814   240 LSASAAGLLLALFgLGGVLGALLAGRLADRFGrRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQA 319


                  ....*...
gi 1810995980 389 MLPDVVDD 396
Cdd:COG2814   320 LVAELAPP 327
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 46-396 4.92e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 42.21  E-value: 4.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980  46 IGGVPNQVASSAVAFYLQLFLLDVAQISAAQVSLVLFGGKVFGAAADPLAGFFINRSRRTgsgRLMpwVLGCmpFIALAY 125
Cdd:cd17329     6 IGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRK---PVM--LAGL--LLRALG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 126 FFLwylspFTSLRGLW-YMTFYCLFQALATFFQVPYTALIMLLTPnPRDRDSGTAYRMTMEMAGTLMGATIHGLIVSGAh 204
Cdd:cd17329    79 FAL-----LGFAHSPWlFAIALVLTGFGGGLFEPASEAMIADVTT-PENRTRAFSLLYWAINLGVAIGPLLGGLLLLYS- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 205 gsqrceedtfpgqvavapsaarlYSTAAAVVAVTYPVCsgLLCLGVKERPDPSATASGQGLSFLSGLCLTVRHPPYLKLV 284
Cdd:cd17329   152 -----------------------FRLLFLAAAVLFLLA--ALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFL 206

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 285 ISFLFISAAVQVEQSYLVLFCTHASRLHDHVQNLVLTI--LVSAVLSTPLWEWLLQrfgKRMSAFGICGIVPFAILLAAV 362
Cdd:cd17329   207 LASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALnaLLIVLLQFPVARLVER---FRLRKILMIGILLFAIGFAVL 283

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1810995980 363 PTAPvAYVVAFVSGVSIAVSLLLPWSMLPDVVDD 396
Cdd:cd17329   284 AFAN-TLAVLILAMIVLTLGEMLVFPAVQTLVAA 316
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
52-200 1.92e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 40.62  E-value: 1.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980  52 QVASSAVAFYLQLFLLDVAQISAAQVSLVLFGGKVFGAAADPLAGFFINRSRRtgsgRLMPWVLGCMPFIALAYFFLWYL 131
Cdd:COG2271   193 YFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGR----RRKLVLAIGLLLAALALLLLALL 268

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1810995980 132 SPFTslrglWYMTFYCLFQALATFFQVPYTALIMLLTPnPRDRDSGTAYRMTMEMAGTLMGATIHGLIV 200
Cdd:COG2271   269 PSPA-----LAIALLFLAGFGLGGAFGLLWALAAELFP-KKARGTASGLVNTFGFLGGALGPLLVGYLL 331
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 56-237 3.50e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 39.85  E-value: 3.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980  56 SAVAFYLQLFLLDVAQISAAQVSLVLFGGKVFGAAADPLAGFFinrSRRTGSGRLMpwVLGCmpfiALAYFFLWYLSPFT 135
Cdd:cd17321   185 GGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRL---ADRFGPRLVL--VAGL----LLTAVGLLLLALLG 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810995980 136 SLRGLWYMTFYCLFQALAT-FFQVPYTALIMLLTPnPRDRDSGTAYRMTMEMAGTLMGATIHGLIVSGAHGSQRCEEDTF 214
Cdd:cd17321   256 ADSSVWLLLPGLVLLGLGLgLFATPLTNAALSSVP-KEKAGAASGILNTARQLGGALGVALLGALLTAGLSANLGDSGVA 334

                         170       180
                  ....*....|....*....|...
gi 1810995980 215 PGQVAVAPSAARLYSTAAAVVAV 237
Cdd:cd17321   335 ALLSAAAAAFAAGFHLAFLVAAA 357
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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