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Conserved domains on  [gi|1785412905|ref|XP_031748947|]
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oocyte zinc finger protein XlCOF7.1-like, partial [Xenopus tropicalis]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 11640384)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
208-396 3.76e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 3.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785412905 208 LQMTGNNHDKNSHQSPHKSHITKNTLRRKYSCIDRHHWTHTG-EKPYSCVECGKTFSNQSHLKTHHRT--HTGE--KPFS 282
Cdd:COG5048   244 SPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFS 323

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785412905 283 CVK--CGKCFPIQSELDRHQRTHTGEKPFLCSECGKCFAQQSHLKI-------HYRTHTGEKPFSC--SECGKCFIDQSN 351
Cdd:COG5048   324 CPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETlsNSCIRNFKRDSN 403

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1785412905 352 LKTHYRTHTGEKP--FSCSECGKCFVRKSHLDRHQRTHTGEKRFSYS 396
Cdd:COG5048   404 LSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCS 450
KRAB_A-box super family cl02581
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 33-62 1.94e-05

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


The actual alignment was detected with superfamily member cd07765:

Pssm-ID: 470626  Cd Length: 40  Bit Score: 41.38  E-value: 1.94e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1785412905  33 IRCEDVSIYFSLEEWEYIK-GNKALYREGIK 62
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDpAQRDLYRDVML 31
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
208-396 3.76e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 3.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785412905 208 LQMTGNNHDKNSHQSPHKSHITKNTLRRKYSCIDRHHWTHTG-EKPYSCVECGKTFSNQSHLKTHHRT--HTGE--KPFS 282
Cdd:COG5048   244 SPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFS 323

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785412905 283 CVK--CGKCFPIQSELDRHQRTHTGEKPFLCSECGKCFAQQSHLKI-------HYRTHTGEKPFSC--SECGKCFIDQSN 351
Cdd:COG5048   324 CPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETlsNSCIRNFKRDSN 403

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1785412905 352 LKTHYRTHTGEKP--FSCSECGKCFVRKSHLDRHQRTHTGEKRFSYS 396
Cdd:COG5048   404 LSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCS 450
zf-H2C2_2 pfam13465
Zinc-finger double domain;
295-320 1.58e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 1.58e-05
                          10        20
                  ....*....|....*....|....*.
gi 1785412905 295 ELDRHQRTHTGEKPFLCSECGKCFAQ 320
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 33-62 1.94e-05

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 41.38  E-value: 1.94e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1785412905  33 IRCEDVSIYFSLEEWEYIK-GNKALYREGIK 62
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDpAQRDLYRDVML 31
KRAB smart00349
krueppel associated box;
36-62 1.66e-03

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 36.42  E-value: 1.66e-03
                           10        20
                   ....*....|....*....|....*...
gi 1785412905   36 EDVSIYFSLEEWEYIK-GNKALYREGIK 62
Cdd:smart00349   4 EDVAVYFTQEEWEQLDpAQKNLYRDVML 31
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 36-59 6.95e-03

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 34.37  E-value: 6.95e-03
                          10        20
                  ....*....|....*....|....*
gi 1785412905  36 EDVSIYFSLEEWEYIK-GNKALYRE 59
Cdd:pfam01352   5 EDVAVDFTQEEWALLDpAQRNLYRD 29
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
208-396 3.76e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 3.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785412905 208 LQMTGNNHDKNSHQSPHKSHITKNTLRRKYSCIDRHHWTHTG-EKPYSCVECGKTFSNQSHLKTHHRT--HTGE--KPFS 282
Cdd:COG5048   244 SPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFS 323

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785412905 283 CVK--CGKCFPIQSELDRHQRTHTGEKPFLCSECGKCFAQQSHLKI-------HYRTHTGEKPFSC--SECGKCFIDQSN 351
Cdd:COG5048   324 CPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETlsNSCIRNFKRDSN 403

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1785412905 352 LKTHYRTHTGEKP--FSCSECGKCFVRKSHLDRHQRTHTGEKRFSYS 396
Cdd:COG5048   404 LSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCS 450
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
196-383 3.46e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 3.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785412905 196 TNTPIMGSSQNTLQMTGNNHDKNSHQSPHKSHITKNTLRRKYSCIDRHHWT--------HTGE--KPYSCVE--CGKTFS 263
Cdd:COG5048   255 SSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLtrhlrsvnHSGEslKPFSCPYslCGKLFS 334

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785412905 264 NQSHLKTHHRTHTGEKPFSCVKCGKCFPIQSELD-------RHQRTHTGEKPFLC--SECGKCFAQQSHLKIHYRTHTGE 334
Cdd:COG5048   335 RNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNneppqslQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSF 414

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1785412905 335 KP--FSCSECGKCFIDQSNLKTHYRTHTGEKPFSCSECGKcFVRKSHLDRH 383
Cdd:COG5048   415 RPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
295-320 1.58e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 1.58e-05
                          10        20
                  ....*....|....*....|....*.
gi 1785412905 295 ELDRHQRTHTGEKPFLCSECGKCFAQ 320
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 33-62 1.94e-05

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 41.38  E-value: 1.94e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1785412905  33 IRCEDVSIYFSLEEWEYIK-GNKALYREGIK 62
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDpAQRDLYRDVML 31
zf-H2C2_2 pfam13465
Zinc-finger double domain;
351-376 2.84e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 2.84e-05
                          10        20
                  ....*....|....*....|....*.
gi 1785412905 351 NLKTHYRTHTGEKPFSCSECGKCFVR 376
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 249-332 4.23e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.48  E-value: 4.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785412905 249 GEKPYSC--VECGKTFSNQSHLKtHHRTHtgekpfscvkcGKCFPIQSEL---DRHQRTHTGEKPFLCSECGKCFAQQSH 323
Cdd:COG5189   346 DGKPYKCpvEGCNKKYKNQNGLK-YHMLH-----------GHQNQKLHENpspEKMNIFSAKDKPYRCEVCDKRYKNLNG 413


                  ....*....
gi 1785412905 324 LKIHyRTHT 332
Cdd:COG5189   414 LKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
323-346 1.96e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 1.96e-04
                          10        20
                  ....*....|....*....|....
gi 1785412905 323 HLKIHYRTHTGEKPFSCSECGKCF 346
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 365-387 2.06e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.05  E-value: 2.06e-04
                          10        20
                  ....*....|....*....|...
gi 1785412905 365 FSCSECGKCFVRKSHLDRHQRTH 387
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 253-275 3.01e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 3.01e-04
                          10        20
                  ....*....|....*....|...
gi 1785412905 253 YSCVECGKTFSNQSHLKTHHRTH 275
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 337-359 3.42e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 3.42e-04
                          10        20
                  ....*....|....*....|...
gi 1785412905 337 FSCSECGKCFIDQSNLKTHYRTH 359
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 309-331 1.30e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 1.30e-03
                          10        20
                  ....*....|....*....|...
gi 1785412905 309 FLCSECGKCFAQQSHLKIHYRTH 331
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
KRAB smart00349
krueppel associated box;
36-62 1.66e-03

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 36.42  E-value: 1.66e-03
                           10        20
                   ....*....|....*....|....*...
gi 1785412905   36 EDVSIYFSLEEWEYIK-GNKALYREGIK 62
Cdd:smart00349   4 EDVAVYFTQEEWEQLDpAQKNLYRDVML 31
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
307-368 1.75e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 1.75e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1785412905 307 KPFLCSECGKCFAQQSHLKIHYRTHTGEKPFSCS--ECGKCFIDQSNLKTHYRTHTGEKPFSCS 368
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS 95
zf-H2C2_2 pfam13465
Zinc-finger double domain;
267-290 2.91e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.91e-03
                          10        20
                  ....*....|....*....|....
gi 1785412905 267 HLKTHHRTHTGEKPFSCVKCGKCF 290
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 36-59 6.95e-03

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 34.37  E-value: 6.95e-03
                          10        20
                  ....*....|....*....|....*
gi 1785412905  36 EDVSIYFSLEEWEYIK-GNKALYRE 59
Cdd:pfam01352   5 EDVAVDFTQEEWALLDpAQRNLYRD 29
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
251-312 8.49e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.14  E-value: 8.49e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1785412905 251 KPYSCVECGKTFSNQSHLKTHHRTHTGEKPFSCVKCGkCFPIQS---ELDRHQRTHTGEKPFLCS 312
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSG-CDKSFSrplELSRHLRTHHNNPSDLNS 95
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
335-394 8.72e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.14  E-value: 8.72e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1785412905 335 KPFSCSECGKCFIDQSNLKTHYRTHTGEKPFSCS--ECGKCFVRKSHLDRHQRTHTGEKRFS 394
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDL 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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