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Conserved domains on  [gi|1784884890|ref|XP_031742540|]
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transcription factor SPATULA isoform X2 [Cucumis sativus]

Protein Classification

basic helix-loop-helix domain-containing protein( domain architecture ID 14413557)

basic helix-loop-helix (bHLH) domain-containing protein is a DNA-binding protein that may act as a transcription factor

Gene Ontology:  GO:0003677
PubMed:  20219281

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
bHLH_AtPIF_like cd11445
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana phytochrome interacting ...
174-236 9.81e-39

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana phytochrome interacting factors (PIFs) and similar proteins; The family includes several bHLH transcription factors from Arabidopsis thaliana, such as PIFs, ALC, PIL1, SPATULA, and UNE10. PIFs (PIF1, PIF3, PIF4, PIF5, PIF6 and PIF7) have been shown to control light-regulated gene expression. They directly bind to the photoactivated phytochromes and are degraded in response to light signals. ALC, also termed AtbHLH73, or protein ALCATRAZ, or EN 98, is required for the dehiscence of fruit, especially for the separation of the valve cells from the replum. It promotes the differentiation of a strip of labile non-lignified cells sandwiched between layers of lignified cells. PIL1, also termed AtbHLH124, or protein phytochrome interacting factor 3-like 1, or EN 110, is involved in responses to transient and long-term shade. It is required for the light-mediated inhibition of hypocotyl elongation and necessary for rapid light-induced expression of the photomorphogenesis- and circadian-related gene APRR9. PIL1 seems to play a role in multiple PHYB responses, such as flowering transition and petiole elongation. SPATULA, also termed AtbHLH24, or EN 99, plays a role in floral organogenesis. It promotes the growth of carpel margins and of pollen tract tissues derived from them. UNE10, also termed AtbHLH16, or protein UNFERTILIZED EMBRYO SAC 10, or EN 99, is required during the fertilization of ovules by pollen.


:

Pssm-ID: 381451  Cd Length: 64  Bit Score: 133.65  E-value: 9.81e-39
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1784884890 174 RAAEVHNLSEKRRRSRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLSMRNGL 236
Cdd:cd11445     1 RAAEVHNLSERRRRDRINEKMKALQELIPNCNKTDKASMLDEAIEYLKSLQLQVQMMSMGNGM 63
 
Name Accession Description Interval E-value
bHLH_AtPIF_like cd11445
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana phytochrome interacting ...
174-236 9.81e-39

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana phytochrome interacting factors (PIFs) and similar proteins; The family includes several bHLH transcription factors from Arabidopsis thaliana, such as PIFs, ALC, PIL1, SPATULA, and UNE10. PIFs (PIF1, PIF3, PIF4, PIF5, PIF6 and PIF7) have been shown to control light-regulated gene expression. They directly bind to the photoactivated phytochromes and are degraded in response to light signals. ALC, also termed AtbHLH73, or protein ALCATRAZ, or EN 98, is required for the dehiscence of fruit, especially for the separation of the valve cells from the replum. It promotes the differentiation of a strip of labile non-lignified cells sandwiched between layers of lignified cells. PIL1, also termed AtbHLH124, or protein phytochrome interacting factor 3-like 1, or EN 110, is involved in responses to transient and long-term shade. It is required for the light-mediated inhibition of hypocotyl elongation and necessary for rapid light-induced expression of the photomorphogenesis- and circadian-related gene APRR9. PIL1 seems to play a role in multiple PHYB responses, such as flowering transition and petiole elongation. SPATULA, also termed AtbHLH24, or EN 99, plays a role in floral organogenesis. It promotes the growth of carpel margins and of pollen tract tissues derived from them. UNE10, also termed AtbHLH16, or protein UNFERTILIZED EMBRYO SAC 10, or EN 99, is required during the fertilization of ovules by pollen.


Pssm-ID: 381451  Cd Length: 64  Bit Score: 133.65  E-value: 9.81e-39
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1784884890 174 RAAEVHNLSEKRRRSRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLSMRNGL 236
Cdd:cd11445     1 RAAEVHNLSERRRRDRINEKMKALQELIPNCNKTDKASMLDEAIEYLKSLQLQVQMMSMGNGM 63
HLH smart00353
helix loop helix domain;
180-228 2.88e-17

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 75.33  E-value: 2.88e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1784884890  180 NLSEKRRRSRINEKMKALQNLIP---NSNKTDKASMLDEAIEYLKQLQLQVQ 228
Cdd:smart00353   1 NARERRRRRKINEAFDELRSLLPtlpKNKKLSKAEILRLAIEYIKSLQEELQ 52
HLH pfam00010
Helix-loop-helix DNA-binding domain;
177-224 7.62e-13

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 62.86  E-value: 7.62e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1784884890 177 EVHNLSEKRRRSRINEKMKALQNLIPNSN---KTDKASMLDEAIEYLKQLQ 224
Cdd:pfam00010   3 EAHNERERRRRDRINDAFDELRELLPTLPpdkKLSKAEILRLAIEYIKHLQ 53
 
Name Accession Description Interval E-value
bHLH_AtPIF_like cd11445
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana phytochrome interacting ...
174-236 9.81e-39

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana phytochrome interacting factors (PIFs) and similar proteins; The family includes several bHLH transcription factors from Arabidopsis thaliana, such as PIFs, ALC, PIL1, SPATULA, and UNE10. PIFs (PIF1, PIF3, PIF4, PIF5, PIF6 and PIF7) have been shown to control light-regulated gene expression. They directly bind to the photoactivated phytochromes and are degraded in response to light signals. ALC, also termed AtbHLH73, or protein ALCATRAZ, or EN 98, is required for the dehiscence of fruit, especially for the separation of the valve cells from the replum. It promotes the differentiation of a strip of labile non-lignified cells sandwiched between layers of lignified cells. PIL1, also termed AtbHLH124, or protein phytochrome interacting factor 3-like 1, or EN 110, is involved in responses to transient and long-term shade. It is required for the light-mediated inhibition of hypocotyl elongation and necessary for rapid light-induced expression of the photomorphogenesis- and circadian-related gene APRR9. PIL1 seems to play a role in multiple PHYB responses, such as flowering transition and petiole elongation. SPATULA, also termed AtbHLH24, or EN 99, plays a role in floral organogenesis. It promotes the growth of carpel margins and of pollen tract tissues derived from them. UNE10, also termed AtbHLH16, or protein UNFERTILIZED EMBRYO SAC 10, or EN 99, is required during the fertilization of ovules by pollen.


Pssm-ID: 381451  Cd Length: 64  Bit Score: 133.65  E-value: 9.81e-39
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1784884890 174 RAAEVHNLSEKRRRSRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLSMRNGL 236
Cdd:cd11445     1 RAAEVHNLSERRRRDRINEKMKALQELIPNCNKTDKASMLDEAIEYLKSLQLQVQMMSMGNGM 63
bHLH_AtbHLH_like cd11393
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription ...
179-231 1.98e-24

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription factors and similar proteins; bHLH proteins are the second largest class of plant transcription factors that regulate transcription of genes that are involve in many essential physiological and developmental process. bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. The Arabidopsis bHLH proteins that have been characterized so far have roles in regulation of fruit dehiscence, cell development (carpel, anther and epidermal), phytochrome signaling, flavonoid biosynthesis, hormone signaling and stress responses.


Pssm-ID: 381399 [Multi-domain]  Cd Length: 53  Bit Score: 94.94  E-value: 1.98e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1784884890 179 HNLSEKRRRSRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLS 231
Cdd:cd11393     1 HSIAERKRREKINERIRALRSLVPNGGKTDKASILDEAIEYIKFLQEQVKVLS 53
bHLH_AtBPE_like cd18919
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana BIG PETAL (BPE) and similar ...
170-233 2.24e-19

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana BIG PETAL (BPE) and similar proteins; The family includes several bHLH transcription factors from Arabidopsis thaliana, such as BPE, HBI1 and BEE proteins (BEE1-3). BPE, also termed AtbHLH31, or EN 88, is involved in the control of Arabidopsis petal size, by interfering with postmitotic cell expansion to limit final petal cell size. HBI1, also termed AtbHLH64, or homolog of bee2 interacting with IBH1, or EN 79, is an atypical bHLH transcription factor that acts as positive regulator of cell elongation downstream of multiple external and endogenous signals by direct binding to the promoters and activation of the two expansin genes EXPA1 and EXPA8, encoding cell wall loosening enzymes. BEEs, also termed protein Brassinosteroid enhanced expression, are positive regulators of brassinosteroid signaling.


Pssm-ID: 381489  Cd Length: 86  Bit Score: 82.10  E-value: 2.24e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1784884890 170 SKRSRAAEVHNLSEKRRRSRINEKMKALQNLIPNSNK-TDKASMLDEAIEYLKQLQLQVQMLSMR 233
Cdd:cd18919     7 ARRGQATDSHSLAERVRREKISERMKLLQDLVPGCNKvTGKALMLDEIINYVQSLQRQVEFLSMK 71
HLH smart00353
helix loop helix domain;
180-228 2.88e-17

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 75.33  E-value: 2.88e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1784884890  180 NLSEKRRRSRINEKMKALQNLIP---NSNKTDKASMLDEAIEYLKQLQLQVQ 228
Cdd:smart00353   1 NARERRRRRKINEAFDELRSLLPtlpKNKKLSKAEILRLAIEYIKSLQEELQ 52
bHLH_AtIND_like cd11454
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein INDEHISCENT (IND) ...
181-234 3.31e-17

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein INDEHISCENT (IND) and similar proteins; The family includes several bHLH transcription factors from Arabidopsis thaliana, such as IND, HEC proteins (HEC1, HEC2 and HEC3) and UNE12. IND, also termed AtbHLH40, or EN 120, is a bHLH transcription regulator required for seed dispersal. It is involved in the differentiation of all three cell types required for fruit dehiscence. HEC1 (also termed AtbHLH88, or protein HECATE 1, or EN 118), HEC2 (also termed AtbHLH37, or protein HECATE 2, or EN 117) and HEC3 (also termed AtbHLH43, or protein HECATE 3, or EN 119) are required for the female reproductive tract development and fertility. Both IND and HEC proteins have been implicated in regulation of auxin signaling. They heterodimerize with SPATULA (SPT) bHLH transcription factor to regulate reproductive tract development in plant. UNE12, also termed AtbHLH59, or protein UNFERTILIZED EMBRYO SAC 12, or EN 93, is required for ovule fertilization.


Pssm-ID: 381460  Cd Length: 63  Bit Score: 75.51  E-value: 3.31e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1784884890 181 LSEKRRRSRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLSMRN 234
Cdd:cd11454     7 VAARHRRERISERIRILQRLVPGGTKMDTASMLDEAIHYVKFLQLQVKLLQSDD 60
bHLH_AtTT8_like cd11451
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein transparent testa 8 ...
179-241 1.45e-15

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein transparent testa 8 (TT8) and similar proteins; The family includes several bHLH transcription factors from Arabidopsis thaliana, such as TT8, EGL1, and GL3. TT8, also termed AtbHLH42, or EN 32, is involved in the control of flavonoid pigmentation and plays a key role in regulating leucoanthocyanidin reductase (BANYULS) and dihydroflavonol-4-reductase (DFR). EGL1, also termed AtbHLH2, or EN 30, or AtMYC146, or protein enhancer of GLABRA 3, is involved in epidermal cell fate specification and regulates negatively stomata formation but promotes trichome formation. GL3, also termed AtbHLH1, or AtMYC6, or protein shapeshifter, or EN 31, is involved in epidermal cell fate specification. It regulates negatively stomata formation, but, in association with TTG1 and MYB0/GL1, promotes trichome formation, branching and endoreplication.


Pssm-ID: 381457  Cd Length: 75  Bit Score: 70.91  E-value: 1.45e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1784884890 179 HNLSEKRRRSRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLSMRNGLSLHPM 241
Cdd:cd11451     6 HAMAERRRREKLNERFITLRSMVPFVTKMDKVSILGDAIEYLKQLQRRVEELESRRKSSDTET 68
bHLH_AtMYC1_like cd18918
basic Helix-Loop-Helix (bHLH) domain found in Arabidopsis thaliana MYC1 and similar proteins; ...
179-232 4.08e-15

basic Helix-Loop-Helix (bHLH) domain found in Arabidopsis thaliana MYC1 and similar proteins; MYC1, also termed AtbHLH12, or EN 58, acts as a transcription activator, when associated with MYB75/PAP1 or MYB90/PAP2.


Pssm-ID: 381488 [Multi-domain]  Cd Length: 70  Bit Score: 69.67  E-value: 4.08e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1784884890 179 HNLSEKRRRSRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLSM 232
Cdd:cd18918     1 LFATERERREKLNEKFSDLRNLIPNPTKNDRASILSDAIKYINELQRTVEELKS 54
bHLH_AtBIM_like cd11453
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana BES1-interacting Myc-like ...
169-230 3.98e-14

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana BES1-interacting Myc-like proteins (BIMs) and similar proteins; The family includes Arabidopsis thaliana BIM1 and its homologs (BIM2 and BIM3), which are bHLH transcription factors that interact with BES1 to regulate transcription of Brassinosteroid (BR)-induced gene. BR regulates many growth and developmental processes such as cell elongation, vascular development, senescence stress responses, and photomorphogenesis. BIM1 heterodimerize with BES1 and bind to E-box sequences present in many BR-induced promoters to regulated BR-induced genes.


Pssm-ID: 381459  Cd Length: 77  Bit Score: 67.11  E-value: 3.98e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1784884890 169 SSKRSRaaevHNLSEKRRRSRINEKMKALQNLIPNSN-KTDKASMLDEAIEYLKQLQLQVQML 230
Cdd:cd11453     1 STPRSK----HSATEQRRRSKINERLQALRDLIPHSDqKRDKASFLLEVIEYIQALQEKVAKL 59
bHLH_AtAIG1_like cd11455
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein AIG1 and similar ...
175-228 1.80e-13

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein AIG1 and similar proteins; AIG1, also termed AtbHLH32, or EN 54, or protein target of MOOPTEROS 5, is a transcription factor required for MONOPTEROS-dependent root initiation in embryo.


Pssm-ID: 381461  Cd Length: 80  Bit Score: 65.39  E-value: 1.80e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1784884890 175 AAEVHNLSEKRRRSRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQ 228
Cdd:cd11455     7 ASKSHSEAERRRRERINSHLATLRTLLPNLSKTDKASLLAEVVQHVKELKRQAA 60
HLH pfam00010
Helix-loop-helix DNA-binding domain;
177-224 7.62e-13

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 62.86  E-value: 7.62e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1784884890 177 EVHNLSEKRRRSRINEKMKALQNLIPNSN---KTDKASMLDEAIEYLKQLQ 224
Cdd:pfam00010   3 EAHNERERRRRDRINDAFDELRELLPTLPpdkKLSKAEILRLAIEYIKHLQ 53
bHLH_AtNAI1_like cd11452
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein NAI1 and similar ...
179-230 7.86e-12

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein NAI1 and similar proteins; NAI1, also termed AtbHLH20, or EN 27, is a bHLH transcription activator that regulates the expression of at least NAI2, PYK10 and PBP1. It is required for and mediates the formation of endoplasmic reticulum bodies (ER bodies). It plays a role in the symbiotic interactions with the endophytes of the Sebacinaceae fungus family, such as Piriformospora indica and Sebacina.


Pssm-ID: 381458 [Multi-domain]  Cd Length: 75  Bit Score: 60.56  E-value: 7.86e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1784884890 179 HNLSEKRRRSRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQML 230
Cdd:cd11452     6 HILAERKRREKLSQRFIALSALVPGLKKMDKASVLGDAIKHIKQLQERVKEL 57
bHLH_AtMEE8_like cd19698
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein maternal effect ...
179-232 1.80e-11

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein maternal effect embryo arrest 8 (AtMEE8) and similar proteins; AtMEE8, also termed AtbHLH108, or EN 132, is a bHLH transcription factor required during early embryo development, for the endosperm formation.


Pssm-ID: 381541  Cd Length: 71  Bit Score: 59.38  E-value: 1.80e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1784884890 179 HNLSEKRRRSRINEKMKALQNLIPN-SNKTDKASMLDEAIEYLKQLQLQVQMLSM 232
Cdd:cd19698     1 HNLLEKKRRERIKDKIEILKGLTPNcTPKSDIASILSCVIDYIKSLLLQVEKLSM 55
bHLH-O_HERP_like cd11389
basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split (HES) ...
179-224 7.41e-11

basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split (HES)-related repressor protein (HERP)-like family; The HERP-like family includes bHLH-O transcriptional regulators that are related to the Drosophila hairy and Enhancer-of-split proteins. They contain a basic helix-loop-helix (bHLH) domain with an invariant glycine residue in its basic region, an orange domain in the central region and YXXW sequence motif at its C-terminal region. HERP proteins (HEY1, HEY2 and HEYL) act as downstream effectors of Notch signaling. They are involved in cardiovascular development and have roles in somitogenesis, myogenesis and gliogenesis. Hairy and enhancer of split-related protein HELT is a transcriptional repressor expressed in the developing central nervous system. It binds preferentially to the canonical E box sequence 5'-CACGCG-3' and regulates neuronal differentiation and/or identity. Differentially expressed in chondrocytes proteins, DEC1 and DEC2, are widely expressed in both embryonic and adult tissues and have been implicated in apoptosis, cell proliferation, and circadian rhythms, as well as malignancy in various cancers. Drosophila melanogaster protein clockwork orange (Cwo) is also included in this family. It is involved in the regulation of Drosophila circadian rhythms. It functions as both an activator and a repressor of clock gene expression.


Pssm-ID: 381395 [Multi-domain]  Cd Length: 55  Bit Score: 57.33  E-value: 7.41e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1784884890 179 HNLSEKRRRSRINEKMKALQNLIPN------SNKTDKASMLDEAIEYLKQLQ 224
Cdd:cd11389     1 HKVIEKRRRDRINESLAELRRLVPEarkskgSGKLEKAEILEMTLQHLKALQ 52
bHLH_AtAMS_like cd11443
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein aborted microspores ...
180-230 8.82e-11

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein aborted microspores (AMS) and similar proteins; The family includes several bHLH transcription factors from Arabidopsis thaliana, such as AMS, ICE1 and SCREAM2. AMS, also termed AtbHLH21, or EN 48, plays a crucial role in tapetum development and it is required for male fertility and pollen differentiation. ICE1, also termed inducer of CBF expression 1, or AtbHLH116, or EN 45, or SCREAM, acts as a transcriptional activator that regulates the cold-induced transcription of CBF/DREB1 genes. It binds specifically to the MYC recognition sites (5'-CANNTG-3') found in the CBF3/DREB1A promoter. SCREAM2, also termed AtbHLH33, or EN 44, mediates stomatal differentiation in the epidermis probably by controlling successive roles of SPCH, MUTE, and FAMA.


Pssm-ID: 381449 [Multi-domain]  Cd Length: 72  Bit Score: 57.39  E-value: 8.82e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1784884890 180 NL-SEKRRRSRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQML 230
Cdd:cd11443     3 NLmAERRRRKKLNDRLYMLRSVVPKITKMDRASILGDAIDYVKELLQEINEL 54
bHLH_SOHLH_like cd19683
basic helix-loop-helix (bHLH) domain found in the spermatogenesis- and oogenesis-specific ...
177-224 1.66e-10

basic helix-loop-helix (bHLH) domain found in the spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein (SOHLH) family and similar proteins; The SOHLH family includes two bHLH transcription factors, SOHLH1 and SOHLH2. They are specifically in spermatogonia and oocytes and essential for early spermatogonial and oocyte differentiation. The family also includes transcription factor-like 5 protein (TCFL5) and similar proteins. TCFL5, also termed Cha transcription factor, or HPV-16 E2-binding protein 1 (E2BP-1), is a bHLH transcription factor that plays a crucial role in spermatogenesis. It regulates cell proliferation or differentiation of cells through binding to a specific DNA sequence like other bHLH molecules.


Pssm-ID: 381526  Cd Length: 58  Bit Score: 56.20  E-value: 1.66e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1784884890 177 EVHNLSEKRRRSRINEKMKALQNLIP-NSNKTDKASMLDEAIEYLKQLQ 224
Cdd:cd19683     4 ERHNAKERQRRERIKIACDQLRKLVPgCSRKTDKATVFEFTVAYIKFLR 52
bHLH_SF cd00083
basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators ...
183-224 4.74e-10

basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. Members of the bHLH superfamily have two highly conserved and functionally distinct regions. The basic part is at the amino end of the bHLH that may bind DNA to a consensus hexanucleotide sequence known as the E box (CANNTG). Different families of bHLH proteins recognize different E-box consensus sequences. At the carboxyl-terminal end of the region is the HLH region that interacts with other proteins to form homo- and heterodimers. bHLH proteins function as a diverse set of regulatory factors because they recognize different DNA sequences and dimerize with different proteins. The bHLH proteins can be divided to cell-type specific and widely expressed proteins. The cell-type specific members of bHLH superfamily are involved in cell-fate determination and act in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis.


Pssm-ID: 381392 [Multi-domain]  Cd Length: 46  Bit Score: 54.45  E-value: 4.74e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1784884890 183 EKRRRSRINEKMKALQNLIPNSN---KTDKASMLDEAIEYLKQLQ 224
Cdd:cd00083     1 ERRRRDKINDAFEELKRLLPELPdskKLSKASILQKAVEYIRELQ 45
bHLHzip_MITF_like cd11397
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the microphthalmia-associated ...
179-230 9.42e-10

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the microphthalmia-associated transcription factor family (MITF) family; The MITF (also known as microphthalmia-TFE, or MiT) family is a small family that contain a basic helix loop helix domain associated with a leucine zipper (bHLHZip). The MITF family comprises four genes in mammals (MITF, TFE3, TFEB, and TFEC); each gene has different functions. MITF is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. TFEB is required for vascularization of the mouse placenta. TFE3 is involved in B cell function. TFEC regulates gene expression in macrophages. The MITF family can form homodimers or heterodimers with each other but not with other bHLH or bHLHzip proteins.


Pssm-ID: 381403  Cd Length: 69  Bit Score: 54.61  E-value: 9.42e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1784884890 179 HNLSEKRRRSRINEKMKALQNLIPNSNKTD----KASMLDEAIEYLKQLQLQVQML 230
Cdd:cd11397     9 HNMIERRRRFNINDRIKELGTLLPKSNDPDmrwnKGTILKASVDYIRKLQKEQERL 64
bHLH_AtFIT_like cd11450
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana Fe-deficiency induced ...
182-230 1.30e-09

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana Fe-deficiency induced transcription factor 1 (FIT) and similar proteins; The family includes bHLH transcription factors from Arabidopsis thaliana, such as FIT and DYT1. FIT, also termed FER-like iron deficiency-induced transcription factor, or FER-like regulator of iron uptake, or AtbHLH29, or EN 43, is a bHLH transcription factor that is required for the iron deficiency response in plant. It regulates FRO2 at the level of mRNA accumulation and IRT1 at the level of protein accumulation. DYT1, also termed AtbHLH22, or protein dysfunctional tapetum 1, or EN 49, is a bHLH transcription factor involved in the control of tapetum development. It is required for male fertility and pollen differentiation, especially during callose deposition.


Pssm-ID: 381456 [Multi-domain]  Cd Length: 76  Bit Score: 54.45  E-value: 1.30e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1784884890 182 SEKRRRSRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQML 230
Cdd:cd11450    10 SERNRRQKLNQRLFALRSVVPNITKMDKASIIKDAISYIQELQYQEKKL 58
bHLHzip_USF_MITF cd11387
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family; The USF (upstream ...
179-228 3.16e-09

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family; The USF (upstream stimulatory factor)/MITF (microphthalmia-associated transcription factor) family includes two bHLHzip transcription factor subfamilies. USFs are ubiquitously expressed and key regulators of a wide number of gene regulation networks, including the stress and immune responses, cell cycle and proliferation, lipid and glucid metabolism. USFs recruit chromatin remodeling enzymes and interact with co-activators and the members of the transcription pre-initiation complex. USFs interact with high affinity to E-box regulatory elements. The MITF (also known as microphthalmia-TFE, or MiT) subfamily comprises four genes in mammals (MITF, TFE3, TFEB, and TFEC); each gene has different functions. MITF is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. TFEB is required for vascularization of the mouse placenta. TFE3 is involved in B cell function. TFEC regulates gene expression in macrophages. The MITF subfamily proteins can form homodimers or heterodimers with each other but not with other bHLH or bHLHzip proteins.


Pssm-ID: 381393 [Multi-domain]  Cd Length: 58  Bit Score: 52.64  E-value: 3.16e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1784884890 179 HNLSEKRRRSRINEKMKALQNLIPNSN------KTDKASMLDEAIEYLKQLQLQVQ 228
Cdd:cd11387     2 HNAVERRRRDNINEKIQELGSLVPPSRletkdlKPNKGSILSKAVEYIRELQNQNQ 57
bHLHzip_TFEB cd18927
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and ...
167-228 4.05e-09

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins; TFEB, also termed Class E basic helix-loop-helix protein 35 (bHLHe35), is a bHLHzip transcription factor that is required for vascularization of the mouse placenta. It specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Its efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF.


Pssm-ID: 381497  Cd Length: 91  Bit Score: 53.44  E-value: 4.05e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1784884890 167 RSSSKRSRAAEVHNLSEKRRRSRINEKMKALQNLIPNSNKTD----KASMLDEAIEYLKQLQLQVQ 228
Cdd:cd18927     3 RALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKTNDLDvrwnKGTILKASVDYIKRMQKDLQ 68
bHLH_AtAIB_like cd11449
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein ABA-INDUCIBLE ...
179-233 6.19e-09

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein ABA-INDUCIBLE bHLH-TYPE (AIB) and similar proteins; The family includes several bHLH transcription factors from Arabidopsis thaliana, such as AIB and MYC proteins (MYC2, MYC3 and MYC4). AIB, also termed AtbHLH17, or EN 35, is a transcription activator that regulates positively abscisic acid (ABA) response. MYC2, also termed protein jasmonate insensitive 1, or R-homologous Arabidopsis protein 1 (RAP-1), or AtbHLH6, or EN 38, or Z-box binding factor 1 protein, is a transcriptional activator involved in abscisic acid (ABA), jasmonic acid (JA), and light signaling pathways. MYC3, also termed protein altered tryptophan regulation 2, or AtbHLH5, or transcription factor ATR2, or EN 36, is a transcription factor involved in tryptophan, jasmonic acid (JA) and other stress-responsive gene regulation. MYC4, also termed AtbHLH4, or EN 37, is a transcription factor involved in jasmonic acid (JA) gene regulation. MYC2, together with MYC3 and MYC4, controls additively subsets of JA-dependent responses.


Pssm-ID: 381455 [Multi-domain]  Cd Length: 78  Bit Score: 52.39  E-value: 6.19e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1784884890 179 HNLSEKRRRSRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQMLSMR 233
Cdd:cd11449     9 HVEAERQRREKLNQRFYALRAVVPNVSKMDKASLLGDAISYINELKSKVQDMETE 63
bHLHzip_SREBP_like cd11395
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding ...
171-234 7.92e-09

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein (SREBP) family and similar proteins; The SREBP family includes SREBP1 and SREBP2, which are bHLHzip transcriptional activator of genes encoding proteins essential for cholesterol biosynthesis/uptake and fatty acid biosynthesis. SREBP1 and SREBP2 are principally found in the liver and in adipocytes and made up of an N-terminal transcription factor portion (composed of an activation domain, a bHLHzip domain, and a nuclear localization signal), a hydrophobic region containing two membrane spanning regions, and a C-terminal regulatory segment. They recognize a symmetric sterol regulatory element (TCACNCCAC) instead of E-box. The family also includes Saccharomyces cerevisiae transcription factor HMS1 (also termed high-copy MEP suppressor protein 1) and serine-rich protein TYE7. HMS1 is a putative bHLHzip transcription factor involved in exit from mitosis and pseudohyphal differentiation. TYE7, also termed basic-helix-loop-helix protein SGC1, is a putative bHLHzip transcription activator required for Ty1-mediated glycolytic gene expression. TYE7 N-terminal is extremely rich in serine residues. It binds DNA on E-box motifs, 5'-CANNTG-3'. TYE7 is not essential for growth.


Pssm-ID: 381401 [Multi-domain]  Cd Length: 87  Bit Score: 52.34  E-value: 7.92e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1784884890 171 KRSRAAevHNLSEKRRRSRINEKMKALQNLIP------------------NSNKTDKASMLDEAIEYLKQLQLQVQMLSM 232
Cdd:cd11395     1 PRKRLP--HNAIEKRYRSNLNTKIERLRDAIPslrspegksddgglgglaPTTKLSKATILTKAIEYIRHLEQENERLEE 78

                  ..
gi 1784884890 233 RN 234
Cdd:cd11395    79 EN 80
bHLH_AtILR3_like cd11446
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein IAA-leucine ...
183-230 2.41e-08

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein IAA-leucine resistant 3 (ILR3) and similar proteins; ILR3, also termed AtbHLH105, or EN 133, is a bHLH transcription factor that plays a role in resistance to amide-linked indole-3-acetic acid (IAA) conjugates such as IAA-Leu and IAA-Phe. It may regulate gene expression in response to metal homeostasis changes.


Pssm-ID: 381452 [Multi-domain]  Cd Length: 76  Bit Score: 50.79  E-value: 2.41e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1784884890 183 EKRRRSRINEKMKALQNLI-PNSN-KTDKASMLDEAIEYLKQLQLQVQML 230
Cdd:cd11446     5 EKLRRDKLNERFMELSNVLePGRPpKTDKATILGDAIRMLKQLRGEVQKL 54
bHLHzip_SREBP1 cd18921
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding ...
166-234 3.41e-08

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein 1 (SREBP1) and similar proteins; SREBP1, also termed Class D basic helix-loop-helix protein 1 (bHLHd1), or sterol regulatory element-binding transcription factor 1 (SREBF1), is a member of a family of bHLHzip transcription factors that recognize sterol regulatory element 1 (SRE-1). It acts as a transcriptional activator required for lipid homeostasis. It may control transcription of the low-density lipoprotein receptor gene as well as the fatty acid. SREBP1 has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').


Pssm-ID: 381491  Cd Length: 75  Bit Score: 50.28  E-value: 3.41e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1784884890 166 PRSSSKRSraaeVHNLSEKRRRSRINEKMKALQNLIPNSN-KTDKASMLDEAIEYLKQLQLQVQMLSMRN 234
Cdd:cd18921     1 PSKGEKRT----AHNAIEKRYRSSINDKIIELKDLVVGTEaKLNKSAVLRKAIDYIRFLQQSNQKLKQEN 66
bHLHzip_MITF cd18926
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated ...
167-228 4.53e-08

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins; MITF, also termed Class E basic helix-loop-helix protein 32 (bHLHe32), is a bHLHzip transcription factor that is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. It regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. It binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR).


Pssm-ID: 381496  Cd Length: 104  Bit Score: 50.85  E-value: 4.53e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1784884890 167 RSSSKRSRAAEVHNLSEKRRRSRINEKMKALQNLIPNSNKTD----KASMLDEAIEYLKQLQLQVQ 228
Cdd:cd18926     5 RALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDmrwnKGTILKASVDYIRKLQREQQ 70
bHLH-O_HERP_HES cd19685
basic helix-loop-helix-orange (bHLH-O) domain found in HERP/HES-like family; The HERP/HES-like ...
182-227 4.76e-08

basic helix-loop-helix-orange (bHLH-O) domain found in HERP/HES-like family; The HERP/HES-like family includes bHLH-O transcriptional regulators that are related to the Drosophila hairy and Enhancer-of-split (HES) proteins. The HERP (HES-related repressor protein) subfamily proteins contain a basic helix-loop-helix (bHLH) domain with an invariant glycine residue in its basic region, an orange domain in the central region and YXXW sequence motif at its C-terminal region. Hairy and enhancer of split (HES)-related repressor protein (HERP) proteins (HEY1, HEY2 and HEYL) act as downstream effectors of Notch signaling. They are involved in cardiovascular development and have roles in somitogenesis, myogenesis and gliogenesis. Hairy and enhancer of split-related protein HELT is a transcriptional repressor expressed in the developing central nervous system. It binds preferentially to the canonical E box sequence 5'-CACGCG-3' and regulates neuronal differentiation and/or identity. Differentially expressed in chondrocytes proteins, DEC1 and DEC2, are widely expressed in both embryonic and adult tissues and have been implicated in apoptosis, cell proliferation, and circadian rhythms, as well as malignancy in various cancers. Drosophila melanogaster protein clockwork orange (Cwo) is also included in this subfamily. It is involved in the regulation of Drosophila circadian rhythms. It functions as both an activator and a repressor of clock gene expression. The HES subfamily proteins contain a basic helix-loop-helix (bHLH) domain with an invariant proline residue in its basic region, an orange domain in the central region and a conserved tetrapeptide motif, WRPW, at its C-terminal region. They form heterodimers or homodimers via their HLH domain and bind DNA to repress gene transcription that play an essential role in development of both compartment and boundary cells of the central nervous system.


Pssm-ID: 381528 [Multi-domain]  Cd Length: 52  Bit Score: 48.96  E-value: 4.76e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1784884890 182 SEKRRRSRINEKMKALQNLIPNSNKTD------KASMLDEAIEYLKQLQLQV 227
Cdd:cd19685     1 SEKRRRQRINDKLNQLKELLPPNLSKQsrsklsKAEILEMAITELRRLQQEV 52
bHLHzip_scCBP1 cd11398
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae ...
179-224 9.53e-08

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae centromere-binding protein 1 (CBP-1) and similar proteins; CBP-1, also termed centromere promoter factor 1 (CPF1), or centromere-binding factor 1 (CBF1), is a bHLHzip protein that is required for chromosome stability and methionine prototrophy. It binds as a homodimer to the centromere DNA elements I (CDEI, GTCACATG) region of the centromere that is required for optimal centromere function.


Pssm-ID: 381404 [Multi-domain]  Cd Length: 89  Bit Score: 49.26  E-value: 9.53e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1784884890 179 HNLSEKRRRSRINEKMKALQNLIP-NSNKTDKASMLDEAIEYLKQLQ 224
Cdd:cd11398    11 HKEVERRRRENINEGINELAALVPgNAREKNKGAILARAVEYIQELQ 57
bHLH_AtSAC51_like cd18917
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana suppressor of acaulis 51 ...
182-230 1.20e-07

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana suppressor of acaulis 51 (SAC51) and similar proteins; SAC51, also termed AtbHLH142, or EN 128, is a bHLH transcription factor that is involved in stem elongation, probably by regulating a subset of genes involved in this process.


Pssm-ID: 381487  Cd Length: 53  Bit Score: 48.18  E-value: 1.20e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1784884890 182 SEKRRRSRINEKMKALQNLIPNSNKTDKASMLDEAIEYLKQLQLQVQML 230
Cdd:cd18917     4 NEKSRKEKIKKAVKLLRSIVPGGESMDTALVLDEAIDYLKSLKMELQSL 52
bHLH_AtIBH1_like cd11444
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana ILI1-BINDING BHLH 1 (IBH1) ...
182-232 1.30e-07

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana ILI1-BINDING BHLH 1 (IBH1) and similar proteins; The family includes several bHLH transcription factors from Arabidopsis thaliana, such as IBH1, UPBEAT1, PAR1 and PAR2. IBH1, also termed bHLH zeta, or AtbHLH158, is an atypical and probable non DNA-binding bHLH transcription factor that acts as transcriptional repressor that negatively regulates cell and organ elongation in response to gibberellin (GA) and brassinosteroid (BR) signaling. IBH1 forms heterodimer with BHLH49, thus inhibiting DNA binding of BHLH49, which is a transcriptional activator that regulates the expression of a subset of genes involved in cell expansion by binding to the G-box motif. UPBEAT1, also termed AtbHLH151, or EN 146, is a bHLH transcription factor that modulates the balance between cellular proliferation and differentiation in root growth. It does not act through cytokinin and auxin signaling, but by repressing peroxidase expression in the elongation zone. PAR1 (also termed AtbHLH165, or protein helix-loop-helix 1, or protein phytochrome rapidly regulated 1) and PAR2 (also termed AtbHLH166, or protein helix-loop-helix 2, or protein phytochrome rapidly regulated 2) are two atypical bHLH transcription factors that act as negative regulators of a variety of shade avoidance syndrome (SAS) responses, including seedling elongation and photosynthetic pigment accumulation. They act as direct transcriptional repressor of two auxin-responsive genes, SAUR15 and SAUR68. They may function in integrating shade and hormone transcriptional networks in response to light and auxin changes.


Pssm-ID: 381450  Cd Length: 57  Bit Score: 48.00  E-value: 1.30e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1784884890 182 SEKRRRSRINEKMKALQNLIPN-SNKTDKASMLDEAIEYLKQLQLQVQMLSM 232
Cdd:cd11444     4 RRRRGEEAIERRLRALRRLVPGgRESMEVEELLQETADYIMFLEMQVKVMKS 55
bHLH_SOHLH1_2 cd18908
basic helix-loop-helix (bHLH) domain found in the spermatogenesis- and oogenesis-specific ...
176-228 1.34e-07

basic helix-loop-helix (bHLH) domain found in the spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein (SOHLH) family; The SOHLH family includes two bHLH transcription factors, SOHLH1 and SOHLH2. They are specifically in spermatogonia and oocytes and essential for early spermatogonial and oocyte differentiation.


Pssm-ID: 381478 [Multi-domain]  Cd Length: 59  Bit Score: 48.10  E-value: 1.34e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1784884890 176 AEVHNLSEKRRRSRINEKMKALQNLIPN--SNKTDKASMLDEAIEYLKQLQLQVQ 228
Cdd:cd18908     3 ASSHSLKERLRRERIKSSCDQLRDLLPYikGRKLDMASVLEMTVKYIRYIQERIP 57
bHLH_AtORG2_like cd18914
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana OBP3-responsive gene 2 ...
177-233 1.34e-07

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana OBP3-responsive gene 2 (ORG2), 3 (ORG3) and similar proteins; The family includes ORG2 (also termed AtbHLH38, or EN 8) and ORG3 (also termed AtbHLH39, or EN 9), both of which act as bHLH transcription factors.


Pssm-ID: 381484 [Multi-domain]  Cd Length: 77  Bit Score: 48.45  E-value: 1.34e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1784884890 177 EVHNLSEKRRRSRINEKMKALQNLIPNSNKTDKASM---LDEAIEYLKQLQLQVQMLSMR 233
Cdd:cd18914     3 LLHNDVERQRRQEMASLFSSLRSLLPLQYIKGKLSVsdhVDEAVNYIKELQEKIKELSEK 62
bHLHzip_TFE3 cd18928
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and ...
167-228 1.65e-07

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and similar proteins; TFE3, also termed Class E basic helix-loop-helix protein 33 (bHLHe33), is a bHLHzip transcription factor that is involved in B cell function. It specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Its efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF.


Pssm-ID: 381498 [Multi-domain]  Cd Length: 91  Bit Score: 48.89  E-value: 1.65e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1784884890 167 RSSSKRSRAAEVHNLSEKRRRSRINEKMKALQNLIPNSN----KTDKASMLDEAIEYLKQLQLQVQ 228
Cdd:cd18928     3 KAFLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSTdpemRWNKGTILKASVDYIRKLQKEQQ 68
bHLHzip_TFEC cd18925
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EC (TFEC) and ...
171-228 1.93e-07

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EC (TFEC) and similar proteins; TFEC, also termed Class E basic helix-loop-helix protein 34 (bHLHe34), or transcription factor EC-like (TFEC-L), is a bHLHzip transcriptional regulator that acts as a repressor or an activator and regulates gene expression in macrophages. It plays an important role in the niche to expand hematopoietic progenitors through the modulation of several cytokines.


Pssm-ID: 381495  Cd Length: 85  Bit Score: 48.54  E-value: 1.93e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1784884890 171 KRSRAAEVHNLSEKRRRSRINEKMKALQNLIPNSNKTD----KASMLDEAIEYLKQLQLQVQ 228
Cdd:cd18925     1 KERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDmrwnKGTILKASVEYIKWLQKEQQ 62
bHLHzip_MGA_like cd19682
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) ...
177-224 3.66e-07

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) family; The MGA family includes MGA, Schizosaccharomyces pombe ESC1 (spESC1) and similar proteins. MGA, also termed MAX dimerization protein 5 (MAD5), is a dual specificity T-box/ bHLHzip transcription factor that regulates the expression of both Max-network and T-box family target genes. It contains a Myc-like bHLHZip motif and requires heterodimerization with Max for binding to the preferred Myc-Max-binding site CACGTG. In addition to the bHLHZip domain, MGA harbors a second DNA-binding domain, the T-box or T-domain. It thus binds the preferred Brachyury-binding sequence and represses transcription of reporter genes containing promoter-proximal Brachyury-binding sites. spESC1 is a bHLHzip protein with homology to human MyoD and Myf-5 myogenic differentiation inducers. It is involved in the sexual differentiation process.


Pssm-ID: 381525 [Multi-domain]  Cd Length: 65  Bit Score: 46.88  E-value: 3.66e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1784884890 177 EVHNLSEKRRRSRINEKMKALQNL--IPNSNKTDKASMLDEAIEYLKQLQ 224
Cdd:cd19682     2 LRHKKRERERRSELRELFDKLKQLlgLDSDEKASKLAVLTEAIEEIQQLK 51
bHLHzip_MLXIP_like cd11405
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP), ...
171-228 4.54e-07

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP), MLX-interacting protein-like (MLXIPL) and similar proteins; The family includes MLXIP and MLXIPL. MLXIP, also termed Class E basic helix-loop-helix protein 36 (bHLHe36), or transcriptional activator MondoA, is a bHLHZip transcriptional activator that binds DNA as a heterodimer with Mlx. It binds to the canonical E box sequence 5'-CACGTG-3' and plays a role in transcriptional activation of glycolytic target genes. MLXIP is most highly expressed in skeletal muscle and functions as an indirect glucose sensor, by sensing glucose 6-phosphate and shuttling between the nucleus and the cytoplasm. MLXIPL, also termed carbohydrate-responsive element-binding protein (ChREBP), or Class D basic helix-loop-helix protein 14 (bHLHd14), or MLX interactor, or WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a bHLHZip transcriptional factor integral to the regulation of glycolysis and lipogenesis in the liver. It forms heterodimers with the bHLHZip protein Mlx to bind the DNA sequence 5'-CACGTG-3'.


Pssm-ID: 381411 [Multi-domain]  Cd Length: 74  Bit Score: 46.88  E-value: 4.54e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1784884890 171 KRSRAAevHNLSEKRRRSRINEKMKALQNLIPNSN-----KTDKASMLDEAIEYLKQLQLQVQ 228
Cdd:cd11405     1 EQRRLS--HISAEQKRRFNIKSGFDTLQSLIPSLGqnpnqKVSKAAMLQKAAEYIKSLKRERQ 61
bHLHzip_SREBP cd11394
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding ...
161-234 4.84e-07

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein (SREBP) family; The SREBP family includes SREBP1 and SREBP2, which are bHLHzip transcriptional activator of genes encoding proteins essential for cholesterol biosynthesis/uptake and fatty acid biosynthesis. SREBP1 and SREBP2 are principally found in the liver and in adipocytes and made up of an N-terminal transcription factor portion (composed of an activation domain, a bHLHzip domain, and a nuclear localization signal), a hydrophobic region containing two membrane spanning regions, and a C-terminal regulatory segment. They recognize a symmetric sterol regulatory element (TCACNCCAC) instead of E-box.


Pssm-ID: 381400 [Multi-domain]  Cd Length: 73  Bit Score: 46.88  E-value: 4.84e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1784884890 161 PTKPNPRSSskrsraaevHNLSEKRRRSRINEKMKALQNLI-PNSNKTDKASMLDEAIEYLKQLQLQVQMLSMRN 234
Cdd:cd11394     1 PPKVEKRSA---------HNAIEKRYRSSINDRIIELKDLVvGPDAKMNKSAVLRKAIDYIRYLQKVNQKLKQEN 66
bHLHzip_USF cd11396
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factors, USF1, ...
178-229 6.71e-07

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factors, USF1, USF2 and similar proteins; Upstream stimulatory factor 1 and 2 (USF-1 and USF-2) are members of bHLHzip transcription factor family. USFs are ubiquitously expressed and key regulators of a wide number of gene regulation networks, including the stress and immune responses, cell cycle and proliferation, lipid and glucid metabolism. USFs recruit chromatin remodeling enzymes and interact with co-activators and the members of the transcription pre-initiation complex. USFs interact with high affinity to E-box regulatory elements.


Pssm-ID: 381402  Cd Length: 58  Bit Score: 46.14  E-value: 6.71e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1784884890 178 VHNLSEKRRRSRINEKMKALQNLIPNSNK------TDKASMLDEAIEYLKQLQLQVQM 229
Cdd:cd11396     1 THNEVERRRRDKINNWIVKLAKIVPDCEKdnskqgQSKGGILSKACDYIQELRSQNER 58
bHLHzip_SREBP2 cd18922
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding ...
166-224 7.13e-07

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein 2 (SREBP2) and similar proteins; SREBP2, also termed Class D basic helix-loop-helix protein 2 (bHLHd2), or sterol regulatory element-binding transcription factor 2 (SREBF2), is a member of a family of bHLHzip transcription factors that recognize sterol regulatory element 1 (SRE-1). It acts as a transcription activator of cholesterol biosynthesis.


Pssm-ID: 381492 [Multi-domain]  Cd Length: 77  Bit Score: 46.49  E-value: 7.13e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1784884890 166 PRSSSKRSraaeVHNLSEKRRRSRINEKMKALQNLI-PNSNKTDKASMLDEAIEYLKQLQ 224
Cdd:cd18922     1 PKEGERRT----THNIIEKRYRSSINDKIIELKDLVmGTDAKMHKSGVLRKAIDYIKYLQ 56
bHLH-O_HERP cd11407
basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split (HES) ...
183-224 1.21e-06

basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split (HES)-related repressor protein (HERP) family; HERP (also called Hey/Hesr/HRT/CHF/gridlock) proteins corresponds to a family of bHLH-O transcriptional repressors that are related to the Drosophila hairy and Enhancer-of-split proteins and act as downstream effectors of Notch signaling. They contain a basic helix-loop-helix (bHLH) domain with an invariant glycine residue in its basic region, an orange domain in the central region and YXXW sequence motif at its C-terminal region. HERP proteins are involved in cardiovascular development and have roles in somitogenesis, myogenesis and gliogenesis.


Pssm-ID: 381413 [Multi-domain]  Cd Length: 59  Bit Score: 45.49  E-value: 1.21e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1784884890 183 EKRRRSRINEKMKALQNLIPN------SNKTDKASMLDEAIEYLKQLQ 224
Cdd:cd11407     9 EKRRRDRINNSLAELRRLVPTafekqgSAKLEKAEILQMTVDHLKMLH 56
bHLH-O_HELT cd11408
basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split-related ...
179-224 2.35e-06

basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split-related protein HELT and similar proteins; HELT, also termed HES/HEY-like transcription factor, is a bHLH-O transcriptional repressor expressed in the developing central nervous system. It binds preferentially to the canonical E box sequence 5'-CACGCG-3' and regulates neuronal differentiation and/or identity. HELT could homodimerize and heterodimerize with other bHLH-O protein such as HES-5 or HEY-2 and bound to E box to repress gene transcription.


Pssm-ID: 381414 [Multi-domain]  Cd Length: 56  Bit Score: 44.60  E-value: 2.35e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1784884890 179 HNLSEKRRRSRINEKMKALQNLIP------NSNKTDKASMLDEAIEYLKQLQ 224
Cdd:cd11408     2 HKVIEKRRRDRINRCLNELGKTVPmalakqTSGKLEKAEILEMTVQYLRALH 53
bHLHzip_Mlx_like cd11404
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) family; Mlx, ...
179-224 2.68e-06

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) family; Mlx, also termed Class D basic helix-loop-helix protein 13 (bHLHd13), or Max-like bHLHZip protein, or protein BigMax, or transcription factor-like protein 4, is a Max-like bHLHZip transcription regulator that interacts with the Max network of transcription factors. It forms a sequence-specific DNA-binding protein complex with some member of Mad family (Mad1 and Mad4) and Mondo family but not the Myc family and bind the E-box DNA to control transcription. The family also includes Saccharomyces cerevisiae INO4, which is a bHLH transcriptional activator of phospholipid synthetic genes (such as INO1, CHO1/PSS, CHO2/PEM1, OPI3/PEM2, etc.). It is required for de-repression of phospholipid biosynthetic gene expression in response to inositol deprivation in yeast.


Pssm-ID: 381410 [Multi-domain]  Cd Length: 70  Bit Score: 44.60  E-value: 2.68e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1784884890 179 HNLSEKRRRSRINEKMKALQNLIPN--SNKTDKASMLDEAIEYLKQLQ 224
Cdd:cd11404     6 HVRSEKKRRELIKKGYDELCALVPGldPQKRTKADILQKAADWIQELK 53
bHLHzip_scHMS1_like cd11399
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae transcription ...
179-233 2.86e-06

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae transcription factor HMS1 and similar proteins; HMS1, also termed high-copy MEP suppressor protein 1, is a putative bHLHzip transcription factor involved in exit from mitosis and pseudohyphal differentiation.


Pssm-ID: 381405 [Multi-domain]  Cd Length: 96  Bit Score: 45.54  E-value: 2.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1784884890 179 HNLSEKRRRSRINEKMKALQNLIPN-----------------------SNKTDKASMLDEAIEYL-------KQLQLQVQ 228
Cdd:cd11399     7 HNMIEKRYRSNINDRIAELRDSVPAlreayksargededeedlggltpATKLNKATILSKATEYIrhlekknKRLSRENA 86

                  ....*
gi 1784884890 229 MLSMR 233
Cdd:cd11399    87 SLRER 91
bHLH-PAS_CLOCK_like cd11441
basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in Circadian locomotor output ...
180-221 3.70e-06

basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in Circadian locomotor output cycles protein kaput (CLOCK) and similar proteins; The family includes CLOCK, neuronal PAS domain-containing protein 2 (NPAS2) and non-mammalian circadian clock protein PASD1. CLOCK, also termed Class E basic helix-loop-helix protein 8 (bHLHe8), is a transcriptional activator which forms a core component of the circadian clock. NPAS2, also termed neuronal PAS2, or basic-helix-loop-helix-PAS protein MOP4, or Class E basic helix-loop-helix protein 9 (bHLHe9), or member of PAS protein 4, or PAS domain-containing protein 4, is a transcriptional activator which forms a core component of the circadian clock. PASD1 is evolutionarily related to Circadian locomotor output cycles protein kaput (CLOCK)and functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body.


Pssm-ID: 381447  Cd Length: 54  Bit Score: 43.88  E-value: 3.70e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1784884890 180 NLSEKRRRSRINEKMKALQNLIP-NSNKTDKASMLDEAIEYLK 221
Cdd:cd11441     5 NLSEKKRRDQFNVLINELASMLPgRGRKMDKSTVLKKTIAFLR 47
bHLH_O_HES cd11410
basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split (HES) ...
183-226 5.71e-06

basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split (HES) family; The HES family includes bHLH-O transcriptional regulators that are related to the Drosophila hairy and Enhancer-of-split (HES) proteins. They contain a basic helix-loop-helix (bHLH) domain with an invariant proline residue in its basic region, an orange domain in the central region and a conserved tetrapeptide motif, WRPW, at its C-terminal region. HES family proteins form heterodimers or homodimers via their HLH domain and bind DNA to repress gene transcription that play an essential role in development of both compartment and boundary cells of the central nervous system.


Pssm-ID: 381416 [Multi-domain]  Cd Length: 54  Bit Score: 43.22  E-value: 5.71e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1784884890 183 EKRRRSRINEKMKALQNLIP--------NSNKTDKASMLDEAIEYLKQLQLQ 226
Cdd:cd11410     2 EKKRRARINKSLEQLKTLVLealnkdntRYSKLEKADILEMTVKYLKQLQRS 53
bHLH_PAS cd11391
basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain family; bHLH-PAS domain has been found ...
176-221 8.51e-06

basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain family; bHLH-PAS domain has been found in a large group of bHLH transcription regulators that are involved in gene expression responding to environmental change and controlling aspects of neural development, including proteins from aryl hydrocarbon receptor nuclear translocator (ARNT) family, hypoxia-inducible factor (HIF) family, aryl hydrocarbon receptor (AhR) family, neuronal PAS domain-containing protein (NPAS) family, Circadian locomotor output cycles protein kaput (CLOCK)-like family, and single-minded (SIM) family. bHLH-PAS transcriptional regulatory factors have a bHLH DNA-binding domain followed by two PAS domains and a C-terminal activation or repression domain. bHLH-PAS family members can be divided into class I and class II based on their dimerization partner. bHLH-PAS class I factors include AhR, HIF and SIM. The best characterized bHLH-PAS Class II protein is the ubiquitous ARNT. Some members of bHLH-PAS family act as transcriptional coactivators (such as NCoA) that lack the ability to dimerize and bind DNA.


Pssm-ID: 381397 [Multi-domain]  Cd Length: 55  Bit Score: 42.95  E-value: 8.51e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1784884890 176 AEVHNLSEKRRRSRINEKMKALQNLIP----NSNKTDKASMLDEAIEYLK 221
Cdd:cd11391     1 REKSREAAKKRRDKENAEISELASLLPlppaVGSKLDKLSVLRLAVAYLR 50
bHLH-O_DEC2 cd19750
basic helix-loop-helix-orange (bHLH-O) domain found in differentially expressed in ...
166-235 1.08e-05

basic helix-loop-helix-orange (bHLH-O) domain found in differentially expressed in chondrocytes protein 2 (DEC2) and similar proteins; DEC2, also termed Class E basic helix-loop-helix protein 41 (bHLHe41), or Class B basic helix-loop-helix protein 3 (bHLHb3), or enhancer-of-split and hairy-related protein 1 (SHARP-1), is a bHLH-O transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes.


Pssm-ID: 381593  Cd Length: 92  Bit Score: 43.82  E-value: 1.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1784884890 166 PRSSSKRSRAAEV----HNLSEKRRRSRINEKMKALQNLIPNSNK------TDKASMLDEAIEYLKQL-----QLQVQML 230
Cdd:cd19750     2 PKRGLKRDESKEAyklpHRLIEKKRRDRINECIAQLKDLLPEHLKlttlghLEKAVVLELTLKHLKALtalteQQHQKII 81

                  ....*
gi 1784884890 231 SMRNG 235
Cdd:cd19750    82 ALQNG 86
bHLH-O_DEC cd11409
basic helix-loop-helix-orange (bHLH-O) domain found in differentially expressed in ...
179-235 1.34e-05

basic helix-loop-helix-orange (bHLH-O) domain found in differentially expressed in chondrocytes protein (DEC) family; The DEC family includes two bHLH-O transcriptional repressors, DEC1 and DEC2, which are widely expressed in both embryonic and adult tissues and have been implicated in apoptosis, cell proliferation, and circadian rhythms, as well as malignancy in various cancers. They mediate the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. They are induced by CLOCK:BMAL1 heterodimer via the CACGTG E-box in the promoter.


Pssm-ID: 381415 [Multi-domain]  Cd Length: 75  Bit Score: 43.10  E-value: 1.34e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1784884890 179 HNLSEKRRRSRINEKMKALQNLIPNSNK------TDKASMLDEAIEYLKQL-----QLQVQMLSMRNG 235
Cdd:cd11409     8 HRLIEKKRRDRINECIAQLKDLLPEHLKlttlghLEKAVVLELTLKHLKALtalteQQQQKIIALQNG 75
bHLH_AtFAMA_like cd11448
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein FAMA and similar ...
183-230 1.88e-05

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein FAMA and similar proteins; The family includes several bHLH transcription factors from Arabidopsis thaliana, such as FAMA, MUTE and SPEECHLESS, which work together to regulate the sequential cell fate specification during stomatal development and differentiation. FAMA, also termed AtbHLH97, or EN 14, is a transcription activator required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. It mediates the formation of stomata. MUTE, also termed AtbHLH45, or EN 20, is required for the differentiation of stomatal guard cells, by promoting successive asymmetric cell divisions and the formation of guard mother cells. It promotes the conversion of the leaf epidermis into stomata. SPEECHLESS, also termed AtbHLH98, or EN 19, is required for the initiation and the formation of stomata, by promoting the first asymmetric cell divisions. FAMA, MUTE and SPEECHLESS form heterodimers with SCREAM/ICE1 and SCRM2 to regulate transcription of genes during stomatal development.


Pssm-ID: 381454  Cd Length: 74  Bit Score: 42.33  E-value: 1.88e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1784884890 183 EKRRRSRINEKMKALQNLIPNS--NKTDKASMLDEAIEYLKQLQLQVQML 230
Cdd:cd11448     7 ERNRRKQMNEHLNVLRSLMPGSyiQRGDQASIVGGAIEFVKELEQLLQSL 56
bHLH-O_hairy_like cd18913
basic helix-loop-helix-orange (bHLH-O) domain found in Drosophila melanogaster protein hairy, ...
183-226 2.01e-05

basic helix-loop-helix-orange (bHLH-O) domain found in Drosophila melanogaster protein hairy, protein deadpan and similar proteins; Protein hairy is a bHLH transcriptional repressor of genes that require a bHLH-O protein for their transcription. It acts as a pair-rule protein that regulates embryonic segmentation and adult bristle patterning. Protein deadpan is closely related to the product of the segmentation gene hairy. It is a direct target of Notch signaling and regulates neuroblast self-renewal in Drosophila.


Pssm-ID: 381483 [Multi-domain]  Cd Length: 67  Bit Score: 42.14  E-value: 2.01e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1784884890 183 EKRRRSRINEKMKALQNLIPNSNKTD--------KASMLDEAIEYLKQLQLQ 226
Cdd:cd18913    11 EKRRRARINASLNELKSLLLDALKKDgtrhskleKADILEMTVKHLRQVQRQ 62
bHLH-O_DEC1 cd19749
basic helix-loop-helix-orange (bHLH-O) domain found in differentially expressed in ...
167-236 2.15e-05

basic helix-loop-helix-orange (bHLH-O) domain found in differentially expressed in chondrocytes protein 1 (DEC1) and similar proteins; DEC1, also termed Class E basic helix-loop-helix protein 40 (bHLHe40), or Class B basic helix-loop-helix protein 2 (bHLHb2), or enhancer-of-split and hairy-related protein 2 (SHARP-2), or stimulated by retinoic acid gene 13 protein (STRA13), is a bHLH-O transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes.


Pssm-ID: 381592  Cd Length: 90  Bit Score: 42.66  E-value: 2.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1784884890 167 RSSSKRSRAAE-----VHNLSEKRRRSRINEKMKALQNLIPNSNK------TDKASMLDEAIEYLKQL-----QLQVQML 230
Cdd:cd19749     1 RRGLKRSEDSKdtyklPHRLIEKKRRDRINECIAQLKDLLPEHLKlttlghLEKAVVLELTLKHVKALtslieQQQQKIL 80

                  ....*.
gi 1784884890 231 SMRNGL 236
Cdd:cd19749    81 ALQSGL 86
bHLH-PAS_ARNTL_PASD3 cd11438
basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor ...
175-224 2.64e-05

basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins; ARNTL, also termed Basic-helix-loop-helix-PAS protein MOP3, or brain and muscle ARNT-like 1 (BMAL1), or Class E basic helix-loop-helix protein 5 (bHLHe5), or member of PAS protein 3, or PAS domain-containing protein 3 (PASD3), or bHLH-PAS protein JAP3, is a member of the bHLH-PAS transcription factor family that forms heterodimers with another bHLH-PAS protein, CLOCK (circadian locomotor output cycle kaput), which regulates circadian rhythm. ARNTL-CLOCK heterodimer complex activates transcription from E-box (CANNTG) elements found in the promoter of circadian responsive genes. ARNTL is highly homologous to ARNT.


Pssm-ID: 381444  Cd Length: 64  Bit Score: 41.63  E-value: 2.64e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1784884890 175 AAEVHNLSEKRRRSRINEKMKALQNLIPNSN----KTDKASMLDEAIEYLKQLQ 224
Cdd:cd11438     7 AREAHSQIEKRRRDKMNSFIDELASLVPTCNamsrKLDKLTVLRMAVQHMKTLR 60
bHLHzip_USF3 cd18910
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in basic helix-loop-helix ...
171-224 2.97e-05

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in basic helix-loop-helix domain-containing protein USF3 and similar proteins; USF3, also termed upstream transcription factor 3, is a bHLHzip protein that is involved in the negative regulation of epithelial-mesenchymal transition, the process by which epithelial cells lose their polarity and adhesion properties to become mesenchymal cells with enhanced migration and invasive properties.


Pssm-ID: 381480  Cd Length: 65  Bit Score: 41.52  E-value: 2.97e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1784884890 171 KRSRAAEVHNLSEKRRRSRINEKMKALQNLIPNSNKTDKAS--MLDEAIEYLKQLQ 224
Cdd:cd18910     1 RREKKRESHNEVERRRKDKINAGINKIGELLPDRDAKKQSKnmILEQAYKYIVELK 56
bHLH-PAS_CLOCK cd19734
basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in Circadian locomotor output ...
180-222 3.24e-05

basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in Circadian locomotor output cycles protein kaput (CLOCK) and similar proteins; CLOCK, also termed Class E basic helix-loop-helix protein 8 (bHLHe8), is a bHLH-PAS transcriptional activator which forms a core component of the circadian clock. It forms heterodimers with another bHLH-PAS protein, Brain-Muscle-Arnt-Like (also known as BMAL or ARNT3 or mop3), which regulates circadian rhythm. BMAL1-CLOCK heterodimer complex activates transcription from E-box (CANNTG) elements found in the promoter of circadian responsive genes.


Pssm-ID: 381577  Cd Length: 61  Bit Score: 41.54  E-value: 3.24e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1784884890 180 NLSEKRRRSRINEKMKALQNLIP-NSNKTDKASMLDEAIEYLKQ 222
Cdd:cd19734    12 NKSEKKRRDQFNVLIKELGSMLPgNARKMDKSTVLQKSIDFLRK 55
bHLHzip_TFAP4 cd11419
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and ...
171-230 3.63e-05

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and similar proteins; TFAP4, also termed activating enhancer-binding protein 4, or Class C basic helix-loop-helix protein 41 (bHLHc41), is a bHLHzip transcription factor that activates both viral and cellular genes involved in the regulation of cellular proliferation, stemness, and epithelial-mesenchymal transition by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.


Pssm-ID: 381425  Cd Length: 61  Bit Score: 41.14  E-value: 3.63e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1784884890 171 KRSRAaEVHNLSEKRRRSRINEKMKALQNLIPNSN--KTDKASMLDEAIEYLKQLQLQVQML 230
Cdd:cd11419     1 RRIRR-EIANSNERRRMQSINAGFQSLRTLLPHCDgeKLSKAAILQQTAEYIFSLEQEKTRL 61
bHLHzip_Mnt cd11402
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-binding protein Mnt and similar ...
177-226 3.74e-05

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-binding protein Mnt and similar proteins; Mnt, also termed Class D basic helix-loop-helix protein 3 (bHLHd3), or Myc antagonist MNT, or protein ROX, is a bHLHZip transcriptional repressor that binds DNA as a heterodimer with MAX. It binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'. Mnt has an important role as an antagonist and regulator of Myc activities and it is a potential tumor suppressor. Mnt is ubiquitously expressed. Mnt-deficient mice shown to exhibit early postnatal lethality.


Pssm-ID: 381408 [Multi-domain]  Cd Length: 77  Bit Score: 41.54  E-value: 3.74e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1784884890 177 EVHNLSEKRRRSRINEKMKALQNLIPNSN--KTDKASMLDEAIEYLKQLQLQ 226
Cdd:cd11402     4 EVHNKLEKNRRAHLKECFETLKRQIPNLDdkKTSNLNILRSALRYIQILKRK 55
bHLH-O_HEYL cd11447
basic helix-loop-helix-orange (bHLH-O) domain found in hairy/enhancer-of-split related with ...
166-224 3.80e-05

basic helix-loop-helix-orange (bHLH-O) domain found in hairy/enhancer-of-split related with YRPW motif-like protein (HEYL) and similar proteins; HEYL, also termed Class B basic helix-loop-helix protein 33 (bHLHb33), or hairy-related transcription factor 3 (HRT-3), is a bHLH-O transcriptional repressor that is strongly expressed in the presomitic mesoderm, the somites, the peripheral nervous system and smooth muscle of all arteries and is a downstream effector of the Notch and transforming growth factor-beta pathways. It promotes neuronal differentiation by activating proneural genes and inhibiting other hairy and enhancer of split (HES) and hairy/enhancer-of-split related with YRPW motif protein (HEY) proteins. HEYL also functions as a tumor suppressor involved in the progression of human cancers.


Pssm-ID: 381453 [Multi-domain]  Cd Length: 74  Bit Score: 41.62  E-value: 3.80e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1784884890 166 PRSSSKRSRAAEvHNLSEKRRRSRINEKMKALQNLIPN------SNKTDKASMLDEAIEYLKQLQ 224
Cdd:cd11447     1 TTSSQIQARKKR-RGIIEKRRRDRINSSLSELRRLVPTafekqgSSKLEKAEILQMTVDHLKMLH 64
bHLHzip_USF2 cd18923
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 2 (USF2) ...
166-230 6.80e-05

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 2 (USF2) and similar proteins; USF2, also termed Class B basic helix-loop-helix protein 12 (bHLHb12), or major late transcription factor 2, or FOS-interacting protein (FIP), or upstream transcription factor 2, is a bHLHzip transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.


Pssm-ID: 381493  Cd Length: 80  Bit Score: 41.22  E-value: 6.80e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1784884890 166 PRSSSKRSRaaevHNLSEKRRRSRINEKMKALQNLIPNSN----KT--DKASMLDEAIEYLKQLQLQVQML 230
Cdd:cd18923     3 PRDERRRAQ----HNEVERRRRDKINNWIVQLSKIIPDCNtdnsKTgaSKGGILSKACDYIRELRQTNQRM 69
bHLH-O_HEY2 cd18920
basic helix-loop-helix-orange (bHLH-O) domain found in hairy/enhancer-of-split related with ...
166-224 7.64e-05

basic helix-loop-helix-orange (bHLH-O) domain found in hairy/enhancer-of-split related with YRPW motif protein 2 (HEY2) and similar proteins; HEY2, also termed cardiovascular helix-loop-helix factor 1 (CHF-1), or Class B basic helix-loop-helix protein 32 (bHLHb32), or HES-related repressor protein 2, or hairy and enhancer of split-related protein 2 (HESR-2), or hairy-related transcription factor 2 (HRT-2), or protein gridlock homolog, is a bHLH-O transcriptional repressor expressed preferentially in the developing and adult cardiovascular system. As a downstream effector of Notch signaling, HEY2 may be required for cardiovascular development. It also plays an important role in neurologic development, as well as in the progression of human cancers.


Pssm-ID: 381490 [Multi-domain]  Cd Length: 82  Bit Score: 40.89  E-value: 7.64e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1784884890 166 PRSSSKRSRAAEVHNLSEKRRRSRINEKMKALQNLIPN------SNKTDKASMLDEAIEYLKQLQ 224
Cdd:cd18920     1 PTTTSQIMARKKRRGIIEKRRRDRINNSLSELRRLVPTafekqgSAKLEKAEILQMTVDHLKMLQ 65
bHLHzip_Mlx cd19687
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) and similar ...
174-226 1.06e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) and similar proteins; Mlx, also termed Class D basic helix-loop-helix protein 13 (bHLHd13), or Max-like bHLHZip protein, or protein BigMax, or transcription factor-like protein 4, is a Max-like bHLHZip transcription regulator that interacts with the Max network of transcription factors. It forms a sequence-specific DNA-binding protein complex with some member of Mad family (Mad1 and Mad4) and Mondo family but not the Myc family and bind the E-box DNA to control transcription.


Pssm-ID: 381530 [Multi-domain]  Cd Length: 76  Bit Score: 40.48  E-value: 1.06e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1784884890 174 RAAEVHNLSEKRRRSRINEKMKALQNLIPN--------SNKTDKASMLDEAIEYLKQLQLQ 226
Cdd:cd19687     1 RRREAHTQAEQKRRDAIKKGYDDLQDIVPTcqqqddigSQKLSKATILQRSIDYIQFLHQQ 61
bHLH-O_ESM5_like cd18916
basic helix-loop-helix-orange (bHLH-O) domain found in Drosophila melanogaster Enhancer of ...
181-224 1.27e-04

basic helix-loop-helix-orange (bHLH-O) domain found in Drosophila melanogaster Enhancer of split proteins, E(spl)m5, E(spl)m8 and similar proteins; The family includes two bHLH-O transcriptional repressors, E(spl)m5 and E(spl)m8, which participate in the control of cell fate choice by uncommitted neuroectodermal cells in the embryo. They bind DNA on N-box motifs, 5'-CACNAG-3'.


Pssm-ID: 381486 [Multi-domain]  Cd Length: 59  Bit Score: 39.82  E-value: 1.27e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1784884890 181 LSEKRRRSRINEKMKALQNLIPNSN------KTDKASMLDEAIEYLKQLQ 224
Cdd:cd18916     6 MLERQRRARINKCLSELKTLVAECSgddgclRMDKAEMLETAVAFMRQQQ 55
bHLH-O_HEY1 cd19748
basic helix-loop-helix-orange (bHLH-O) domain found in hairy/enhancer-of-split related with ...
169-224 1.59e-04

basic helix-loop-helix-orange (bHLH-O) domain found in hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1) and similar proteins; HEY1, also termed cardiovascular helix-loop-helix factor 2 (CHF-2), or Class B basic helix-loop-helix protein 31 (bHLHb31), or HES-related repressor protein 1, or hairy and enhancer of split-related protein 1 (HESR-1), or hairy-related transcription factor 1 (HRT-1), is a bHLH-O transcriptional repressor that acts as an essential downstream effector of the Notch signaling pathway and may play a fundamental role in vascular development. HEY1 also participates several cancer-related pathways. It acts as a positive regulator of the tumor suppressor p53.


Pssm-ID: 381591 [Multi-domain]  Cd Length: 71  Bit Score: 39.94  E-value: 1.59e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1784884890 169 SSKRSRAaevhnLSEKRRRSRINEKMKALQNLIPN------SNKTDKASMLDEAIEYLKQLQ 224
Cdd:cd19748     8 ARKRRRG-----IIEKRRRDRINNSLSELRRLVPSafekqgSAKLEKAEILQMTVDHLKMLH 64
bHLH-O_Cwo_like cd11440
basic helix-loop-helix-orange (bHLH-O) domain found in Drosophila melanogaster protein ...
179-226 1.92e-04

basic helix-loop-helix-orange (bHLH-O) domain found in Drosophila melanogaster protein clockwork orange (Cwo) and similar proteins; Cwo is a bHLH-O transcriptional regulator involved in the regulation of Drosophila circadian rhythms. It functions as both an activator and a repressor of clock gene expression.


Pssm-ID: 381446 [Multi-domain]  Cd Length: 60  Bit Score: 39.39  E-value: 1.92e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1784884890 179 HNLSEKRRRSRINEKMKALQNLIPNS------NKTDKASMLDEAIEYLKQLQLQ 226
Cdd:cd11440     6 HRIIEKRRRDRMNNCLADLSRLIPPTylkkgrGRIEKTEIIEMAIKHIKHLQQH 59
bHLH-PAS_ARNT_like cd11437
basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor ...
179-223 2.19e-04

basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) family; The ARNT family of bHLH-PAS transcription regulators includes ARNT, ARNT-like proteins (ARNTL and ARNTL2), and Drosophila melanogaster protein cycle. They act as the heterodimeric partner for bHLH-PAS proteins such as aryl hydrocarbon receptor (AhR), hypoxia-inducible factor (HIF), and single-minded (SIM). These bHLH-PAS transcription complexes are involved in transcriptional responses to xenobiotic, hypoxia, and developmental pathways. Heterodimerization of bHLH-PAS proteins with ARNT is mediated by contacts between both the bHLH and the tandem PAS domains. ARNT use bHLH and/or PAS domains to interact with several transcriptional coactivators. It is required for activity of the aryl hydrocarbon (dioxin) receptor. ARNTL, also termed Basic-helix-loop-helix-PAS protein MOP3, or brain and muscle ARNT-like 1 (BMAL1), or Class E basic helix-loop-helix protein 5 (bHLHe5), or member of PAS protein 3, or PAS domain-containing protein 3 (PASD3), or bHLH-PAS protein JAP3, is a member of the bHLH-PAS transcription factor family that forms heterodimers with another bHLH-PAS protein, CLOCK (circadian locomotor output cycle kaput), which regulates circadian rhythm. ARNTL-CLOCK heterodimer complex activates transcription from E-box (CANNTG) elements found in the promoter of circadian responsive genes. ARNTL is highly homologous to ARNT. ARNTL2, also termed Basic-helix-loop-helix-PAS protein MOP9, or brain and muscle ARNT-like 2 (BMAL2), or CYCLE-like factor (CLIF), or Class E basic helix-loop-helix protein 6 (bHLHe6), or member of PAS protein 9, or PAS domain-containing protein 9 (PASD9), is a neuronal bHLH-PAS transcriptional factor, regulating cell cycle progression and preventing cell death, whose sustained expression might ensure brain neuron survival. It also plays important roles in tumor angiogenesis. Protein cycle, also termed brain and muscle ARNT-like 1 (BMAL1), or MOP3, is a putative bHLH-PAS transcription factor involved in the generation of biological rhythms in Drosophila. It activates cycling transcription of Period (PER) and Timeless (TIM) by binding to the E-box (5'-CACGTG-3') present in their promoters.


Pssm-ID: 381443  Cd Length: 58  Bit Score: 38.94  E-value: 2.19e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1784884890 179 HNLSEKRRRSRINEKMKALQNLIPNSN----KTDKASMLDEAIEYLKQL 223
Cdd:cd11437     5 HSEIEKRRRDKMNAYIQELSALVPACNamsrKLDKLTVLRMAVQHLKSL 53
bHLH_ScPHO4_like cd11392
basic helix-loop-helix (bHLH) domain found in Saccharomyces cerevisiae phosphate system ...
170-227 2.68e-04

basic helix-loop-helix (bHLH) domain found in Saccharomyces cerevisiae phosphate system positive regulatory protein PHO4 and similar proteins; PHO4 is a transcriptional activator that regulates the expression of repressible phosphatase under phosphate starvation conditions in Saccharomyces cerevisiae. The PHO4 protein has four functional domains with the bHLH domain at its carboxyl-terminal region. It regulates transcription by binding to promoter of the genes as a homodimer.


Pssm-ID: 381398  Cd Length: 80  Bit Score: 39.36  E-value: 2.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1784884890 170 SKRsraaEVHNLSEKRRRSRINEKMKALQNLIP---------------NSNKTD---------KASMLDEAIEYLKQLQL 225
Cdd:cd11392     1 SKR----TAHKVAERGRRDRLNAALKELASLMPaefvegkmgadgsasDSNDKEkaaasaagsKAATVEMAIDYIKHLQK 76

                  ..
gi 1784884890 226 QV 227
Cdd:cd11392    77 EV 78
bHLH-O_HES3 cd18933
basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-3 and similar ...
183-228 2.71e-04

basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-3 and similar proteins; HES-3, also termed Class B basic helix-loop-helix protein 43 (bHLHb43), or hairy and enhancer of split 3, is a bHLH-O transcription factor expressed in neural stem and progenitor cells that is involved in tissue regeneration. It regulates gene expression, cell growth, and insulin release. HES-3 is one mammalian counterpart of the Hairy and Enhancer of split proteins that play a critical role in many physiological processes including cellular differentiation, cell cycle arrest, apoptosis and self-renewal ability.


Pssm-ID: 381503 [Multi-domain]  Cd Length: 55  Bit Score: 38.80  E-value: 2.71e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1784884890 183 EKRRRSRINEKMKALQNLIPNS-------NKTDKASMLDEAIEYLKQLQLQVQ 228
Cdd:cd18933     2 EKKRRARINVSLEQLKSLLEKHysnnirkRKLEKADILELTVKYLRSLQNSIQ 54
bHLH-PAS_dCLOCK cd19735
basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in Drosophila melanogaster ...
180-222 3.06e-04

basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in Drosophila melanogaster Circadian locomotor output cycles protein kaput (dCLOCK) and similar proteins; dCLOCK, also termed dPAS1, is a bHLH-PAS Circadian regulator that acts as a transcription factor and generates a rhythmic output with a period of about 24 hours.


Pssm-ID: 381578  Cd Length: 80  Bit Score: 39.39  E-value: 3.06e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1784884890 180 NLSEKRRRSRINEKMKALQNLIPNSN-KTDKASMLDEAIEYLKQ 222
Cdd:cd19735    15 NLSEKKRRDQFNVLINELCSMVSTSNrKMDKSTVLKSTIAFLKN 58
bHLH-O_HES2 cd11463
basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split 2 (HES-2) ...
181-223 3.53e-04

basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split 2 (HES-2) and similar proteins; HES-2, also termed Class B basic helix-loop-helix protein 40 (bHLHb40), is a bHLH-O transcriptional repressor of genes that require a bHLH protein for their transcription. It acts as a negative regulator through interaction with both E-box and N-box sequences. HES-2 is one mammalian counterpart of the Hairy and Enhancer of split proteins that play a critical role in many physiological processes including cellular differentiation, cell cycle arrest, apoptosis and self-renewal ability.


Pssm-ID: 381469 [Multi-domain]  Cd Length: 65  Bit Score: 38.74  E-value: 3.53e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1784884890 181 LSEKRRRSRINEKMKALQNLI--------PNSNKTDKASMLDEAIEYLKQL 223
Cdd:cd11463    11 LMEKRRRARINESLNQLKTLIlplvgkdsSRYSKLEKADILEMTVRFLQDL 61
bHLH-O_HES1_4 cd11459
basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split HES-1, ...
181-226 3.97e-04

basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split HES-1, HES-4 and similar proteins; The family includes two bHLH-O transcriptional repressors, HES-1 and HES-4. HES-1, also termed Class B basic helix-loop-helix protein 39 (bHLHb39), or hairy homolog, or hairy-like protein (HL), plays an essential role in development of both compartment and boundary cells of the central nervous system. It regulates the maintenance of neural stem/progenitor cells by inhibiting proneural gene expression via Notch signaling. HES-4, also termed Class B basic helix-loop-helix protein 42 (bHLHb42), or bHLH factor Hes4, antagonizes the function of Twist-1 to regulate lineage commitment of bone marrow stromal/stem cells (BMSC). Epigenetic dysregulation of HES-4 is associated with striatal degeneration in postmortem Huntington brains. Both HES-1 and HES-4 are mammalian counterparts of the Hairy and Enhancer of split proteins that play a critical role in many physiological processes including cellular differentiation, cell cycle arrest, apoptosis and self-renewal ability.


Pssm-ID: 381465 [Multi-domain]  Cd Length: 63  Bit Score: 38.58  E-value: 3.97e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1784884890 181 LSEKRRRSRINEKMKALQNLIPNSNKTD--------KASMLDEAIEYLKQLQLQ 226
Cdd:cd11459     9 IMEKRRRARINESLSQLKTLILDALKKDssrhskleKADILEMTVKHLRNLQRQ 62
bHLH-PAS_ARNTL2_PASD9 cd11469
basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor ...
177-224 4.34e-04

basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 2 (ARNTL2) and similar proteins; ARNTL2, also termed Basic-helix-loop-helix-PAS protein MOP9, or brain and muscle ARNT-like 2 (BMAL2), or CYCLE-like factor (CLIF), or Class E basic helix-loop-helix protein 6 (bHLHe6), or member of PAS protein 9, or PAS domain-containing protein 9 (PASD9), is a neuronal bHLH-PAS transcriptional factor, regulating cell cycle progression and preventing cell death, whose sustained expression might ensure brain neuron survival. It also plays important roles in tumor angiogenesis. ARNT-2 heterodimerize with other bHLH-PAS proteins such as aryl hydrocarbon receptor (AhR), hypoxia-inducible factor (HIF), and single-minded (SIM).


Pssm-ID: 381475  Cd Length: 60  Bit Score: 38.09  E-value: 4.34e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1784884890 177 EVHNLSEKRRRSRINEKMKALQNLIPNSN----KTDKASMLDEAIEYLKQLQ 224
Cdd:cd11469     3 EAHSQTEKRRRDKMNNLIEELSAMIPQCNpmarKLDKLTVLRMAVQHLKSLK 54
bHLHzip_Max cd11406
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in protein Max and similar proteins; Max, ...
179-224 5.15e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in protein Max and similar proteins; Max, also termed Class D basic helix-loop-helix protein 4 (bHLHd4), or Myc-associated factor X, is a bHLHZip transcription regulator that forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a transcriptional repressor. Max homodimer bind DNA but is transcriptionally inactive. Targeted deletion of max results in early embryonic lethality in mice.


Pssm-ID: 381412  Cd Length: 69  Bit Score: 38.10  E-value: 5.15e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1784884890 179 HNLSEKRRRSRINEKMKALQNLIP--NSNKTDKASMLDEAIEYLKQLQ 224
Cdd:cd11406     5 HNALERKRRDHIKDSFHSLRDSVPslQGEKASRAQILKKATEYIQYMR 52
bHLHzip_Myc cd11400
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a ...
178-233 5.41e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a member of the bHLHzip family of transcription factors that play important roles in the control of normal cell proliferation, growth, survival and differentiation. All Myc isoforms contain two independently functioning polypeptide chain regions: N-terminal transactivating residues and a C-terminal bHLHzip segment. The bHLHzip family of bHLH transcription factors are characterized by a highly conserved N-terminal basic region that may bind DNA at a consensus hexanucleotide sequence known as the E-box (CANNTG) followed by HLH and leucine zipper motifs that may interact with other proteins to form homo- and heterodimers. Myc heterodimerizes with Max enabling specific binding to E-box DNA sequences in the promoters of target genes. The Myc proto-oncoprotein family includes at least five different functional members: c-, N-, L-, S- and B-Myc (which is lacking the bHLH domain).


Pssm-ID: 381406 [Multi-domain]  Cd Length: 80  Bit Score: 38.30  E-value: 5.41e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1784884890 178 VHNLSEKRRRSRINEKMKALQNLIPNSNKTDKAS---MLDEAIEYLKQLQLQVQMLSMR 233
Cdd:cd11400     4 LHNVLERQRRNDLKNSFEKLRDLVPELADNEKASkvvILKKATEYIKQLQQEEKKLEKE 62
bHLHzip_spESC1_like cd19690
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Schizosaccharomyces pombe ESC1 (spESC1) ...
179-230 5.44e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Schizosaccharomyces pombe ESC1 (spESC1) and similar proteins; spESC1 is a bHLHzip protein with homology to human MyoD and Myf-5 myogenic differentiation inducers. It is involved in the sexual differentiation process.


Pssm-ID: 381533  Cd Length: 65  Bit Score: 38.21  E-value: 5.44e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1784884890 179 HNLSEKRRRSRINEKMKALQNLIPNSN--KTDKASMLDEAIEYLKQLQLQVQML 230
Cdd:cd19690     4 HKLAERKRRKEMKELFEDLRDALPQERgtKASKWEILTKAISYIQQLKRHIREL 57
bHLH-O_HES5 cd11461
basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-5 and similar ...
183-226 6.09e-04

basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-5 and similar proteins; HES-5, also termed Class B basic helix-loop-helix protein 38 (bHLHb38), or hairy and enhancer of split 5, is a bHLH-O transcription factor that is involved in cell differentiation and proliferation in a variety of tissues. HES-5 is an essential effector for Notch signaling. It acts as a transducer of Notch signals in brain vascular development. It also acts as a key mediator of Wnt-3a-induced neuronal differentiation and plays a crucial role in normal inner ear hair cell development. HES-5 is one mammalian counterpart of the Hairy and Enhancer of split proteins that play a critical role in many physiological processes including cellular differentiation, cell cycle arrest, apoptosis and self-renewal ability.


Pssm-ID: 381467 [Multi-domain]  Cd Length: 59  Bit Score: 37.71  E-value: 6.09e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1784884890 183 EKRRRSRIN---EKMKAL-----QNLIPNSnKTDKASMLDEAIEYLKQLQLQ 226
Cdd:cd11461     8 EKTRRDRINssiEQLKTLlekefQRHQPNS-KLEKADILEMTVSFLKQSAKL 58
bHLH-O_HES7 cd11462
basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split 7 (HES-7) ...
181-221 8.92e-04

basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split 7 (HES-7) and similar proteins; HES-7, also termed Class B basic helix-loop-helix protein 37 (bHLHb37), or bHLH factor Hes7, is a bHLH-O transcriptional repressor that is expressed in an oscillatory manner and acts as a key regulator of the pace of the segmentation clock. It is regulated by the Notch and Fgf/Mapk pathways. HES-7 is one mammalian counterpart of the Hairy and Enhancer of split proteins that play a critical role in many physiological processes including cellular differentiation, cell cycle arrest, apoptosis and self-renewal ability.


Pssm-ID: 381468 [Multi-domain]  Cd Length: 61  Bit Score: 37.32  E-value: 8.92e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1784884890 181 LSEKRRRSRINEK--------MKALQNLIPNSNKTDKASMLDEAIEYLK 221
Cdd:cd11462     7 LVEKRRRDRINRSleelrvllLQNTQDEKLKNPKVEKAEILELTVQFLR 55
bHLH_TS_MYOG_Myf4 cd18935
basic helix-loop-helix (bHLH) domain found in myogenin (MYOG) and similar proteins; MYOG, also ...
172-230 9.18e-04

basic helix-loop-helix (bHLH) domain found in myogenin (MYOG) and similar proteins; MYOG, also termed Class C basic helix-loop-helix protein 3 (bHLHc3), or myogenic factor 4 (Myf-4), is a bHLH transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy.


Pssm-ID: 381505  Cd Length: 59  Bit Score: 37.33  E-value: 9.18e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1784884890 172 RSRAAevhNLSEKRRRSRINEKMKALQ--NLIPNSNKTDKASMLDEAIEYLKQLQLQVQML 230
Cdd:cd18935     2 RRRAA---TLREKRRLKKVNEAFEALKrsTLLNPNQRLPKVEILRSAIQYIERLQALLSSL 59
bHLH_ScINO2_like cd11388
basic helix-loop-helix (bHLH) domain found in Saccharomyces cerevisiae protein INO2 and ...
179-234 1.06e-03

basic helix-loop-helix (bHLH) domain found in Saccharomyces cerevisiae protein INO2 and similar proteins; INO2 is a positive regulatory factor required for depression of the co-regulated phospholipid biosynthetic enzymes in Saccharomyces cerevisiae. It is also involved in the expression of ITR1.


Pssm-ID: 381394  Cd Length: 68  Bit Score: 37.33  E-value: 1.06e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1784884890 179 HNLSEKRRRSRINEKMKALQNLIP-----NSNKTDKASMLDEAIEYLKQLQLQVQMLSMRN 234
Cdd:cd11388     7 HVEAEKKRRNQIKKGFEDLINLINyprnnNEKRISKSELLNKAVDDIRGLLKANEQLQEEI 67
bHLHzip_L-Myc cd11457
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in L-Myc and similar proteins; L-Myc, ...
179-251 2.19e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in L-Myc and similar proteins; L-Myc, also termed Class E basic helix-loop-helix protein 38 (bHLHe38), or protein L-Myc-1, or V-myc myelocytomatosis viral oncogene homolog, is a bHLHZip oncoprotein belonging to the Myc oncogene protein family. It binds DNA as a heterodimer with MAX. L-Myc is co-expressed with another Myc family member and has weaker transformation/transactivation activities. L-Myc knockout mouse did not exhibit any phenotypic abnormalities.


Pssm-ID: 381463 [Multi-domain]  Cd Length: 89  Bit Score: 37.08  E-value: 2.19e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1784884890 179 HNLSEKRRRSRINEKMKALQNLIP---NSNKTDKASMLDEAIEYLKQLQL-QVQMLSMRNGLSLHPMNLPGSLQYLQ 251
Cdd:cd11457    11 HNFLERKRRNDLRSRFLALRDEVPglaSCSKTPKVVILSKATEYLRGLVSaERRMAAEKRQLKSRQQQLLRRIAQLK 87
bHLH-PAS_NPAS2_PASD4 cd19737
basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing ...
180-222 3.26e-03

basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 2 (NPAS2) and similar proteins; NPAS2, also termed neuronal PAS2, or basic-helix-loop-helix-PAS protein MOP4, or Class E basic helix-loop-helix protein 9 (bHLHe9), or member of PAS protein 4, or PAS domain-containing protein 4 (PASD4), is a bHLH-PAS transcriptional activator which forms a core component of the circadian clock.


Pssm-ID: 381580  Cd Length: 77  Bit Score: 36.30  E-value: 3.26e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1784884890 180 NLSEKRRRSRINEKMKALQNLIP-NSNKTDKASMLDEAIEYLKQ 222
Cdd:cd19737    15 NKSEKKRRDQFNVLIKELSSMLPgNTRKMDKTTVLEKVIGFLQK 58
bHLH-O_ESMB_like cd19741
basic helix-loop-helix-orange (bHLH-O) domain found in Drosophila melanogaster enhancer of ...
181-226 3.29e-03

basic helix-loop-helix-orange (bHLH-O) domain found in Drosophila melanogaster enhancer of split mbeta protein (ESMB) and similar proteins; ESMB, also termed E(spl)mbeta, or HLH-mbeta, or split locus enhancer protein mA, is a bHLH-O transcriptional repressor of genes that require a bHLH protein for their transcription. It is involved in the neural-epidermal lineage decision during early neurogenesis. The family also includes Enhancer of split m7 protein (also known as E(spl)m7), which acts as a transcriptional repressor that participates in the control of cell fate choice by uncommitted neuroectodermal cells in the embryo.


Pssm-ID: 381584 [Multi-domain]  Cd Length: 69  Bit Score: 35.82  E-value: 3.29e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1784884890 181 LSEKRRRSRINEKMKALQNLI--------PNSNKTDKASMLDEAIEYLKQLQLQ 226
Cdd:cd19741    14 LLERKRRARINKCLDELKDLMvealateaENVSKLEKADILELTVRHLKKLRRQ 67
bHLH-PAS_ARNT cd18947
basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor ...
171-224 3.60e-03

basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) and similar proteins; ARNT, also termed Class E basic helix-loop-helix protein 2 (bHLHe2), or Dioxin receptor, nuclear translocator, or hypoxia-inducible factor 1-beta (HIF1b), or HIF-1-beta, or HIF1-beta, is a member of bHLH-PAS transcription regulators that acts as the heterodimeric partner for bHLH-PAS proteins such as aryl hydrocarbon receptor (AhR), hypoxia-inducible factor (HIF), and single-minded (SIM). These bHLH-PAS transcription complexes are involved in transcriptional responses to xenobiotic, hypoxia, and developmental pathways. Heterodimerization of bHLH-PAS proteins with ARNT is mediated by contacts between both the bHLH and the tandem PAS domains. ARNT use bHLH and/or PAS domains to interact with several transcriptional coactivators. It is required for activity of the aryl hydrocarbon (dioxin) receptor.


Pssm-ID: 381517  Cd Length: 65  Bit Score: 35.93  E-value: 3.60e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1784884890 171 KRSRAAEVHNLSEKRRRSRINEKMKALQNLIPNSN----KTDKASMLDEAIEYLKQLQ 224
Cdd:cd18947     1 KERFARENHSEIERRRRNKMTAYITELSDMVPTCSalarKPDKLTILRMAVSHMKSLR 58
bHLHzip_MLXIP cd19688
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP) and ...
179-230 7.24e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP) and similar proteins; MLXIP, also termed Class E basic helix-loop-helix protein 36 (bHLHe36), or transcriptional activator MondoA, is a bHLHZip transcriptional activator that binds DNA as a heterodimer with Mlx. It binds to the canonical E box sequence 5'-CACGTG-3' and plays a role in transcriptional activation of glycolytic target genes. MLXIP is most highly expressed in skeletal muscle and functions as an indirect glucose sensor, by sensing glucose 6-phosphate and shuttling between the nucleus and the cytoplasm.


Pssm-ID: 381531  Cd Length: 72  Bit Score: 35.31  E-value: 7.24e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1784884890 179 HNLSEKRRRSRINEKMKALQNLIP---NSNKTDKASMLDEAIEYLKQLQLQ-VQML 230
Cdd:cd19688     7 HISAEQKRRFNIKICFDTLNSLVStlkNSKPISNAITLQKTVEYIAKLQQErTQMQ 62
bHLH_TS_MRF4_Myf6 cd18934
basic helix-loop-helix (bHLH) domain found in muscle-specific regulatory factor 4 (MRF4) and ...
172-224 8.36e-03

basic helix-loop-helix (bHLH) domain found in muscle-specific regulatory factor 4 (MRF4) and similar proteins; MRF4, also termed Class C basic helix-loop-helix protein 4 (bHLHc4), or myogenic factor 6 (Myf-6), is a bHLH transcription factor associated with myogenesis. It plays a role in skeletal muscle differentiation.


Pssm-ID: 381504  Cd Length: 64  Bit Score: 34.66  E-value: 8.36e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1784884890 172 RSRAAevhNLSEKRRRSRINEKMKALQ-NLIPNSN-KTDKASMLDEAIEYLKQLQ 224
Cdd:cd18934     2 RRKAA---TLRERRRLKKINEAFEALKrRTVPNPNqRLPKVEILRSAINYIEKLQ 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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