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Conserved domains on  [gi|1721908663|ref|XP_030237525|]
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arsenite methyltransferase-like [Gadus morhua]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 1000582)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to Homo sapiens arsenite methyltransferase

CATH:  3.40.50.150
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168|GO:0032259|GO:0008757
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
arsM super family cl30592
arsenite methyltransferase;
82-234 3.45e-39

arsenite methyltransferase;


The actual alignment was detected with superfamily member PRK11873:

Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 140.47  E-value: 3.45e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663  82 VLDLGSGSGRDCYMLSKLVGEKGNVTGIDMTEKLLEVARTytdyhtQAFGYKAPNIRFVQGYLEALNeagIEGSAYDICI 161
Cdd:PRK11873   81 VLDLGSGGGFDCFLAARRVGPTGKVIGVDMTPEMLAKARA------NARKAGYTNVEFRLGEIEALP---VADNSVDVII 151

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1721908663 162 SNGAVNLCPDKKPVLQEAYRVLKEGGELYFSDVYSSGRLTEEIRNSNVLWGECLSGALWWEDLMQLAEEVGFS 234
Cdd:PRK11873  152 SNCVINLSPDKERVFKEAFRVLKPGGRFAISDVVLRGELPEEIRNDAELYAGCVAGALQEEEYLAMLAEAGFV 224
 
Name Accession Description Interval E-value
arsM PRK11873
arsenite methyltransferase;
82-234 3.45e-39

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 140.47  E-value: 3.45e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663  82 VLDLGSGSGRDCYMLSKLVGEKGNVTGIDMTEKLLEVARTytdyhtQAFGYKAPNIRFVQGYLEALNeagIEGSAYDICI 161
Cdd:PRK11873   81 VLDLGSGGGFDCFLAARRVGPTGKVIGVDMTPEMLAKARA------NARKAGYTNVEFRLGEIEALP---VADNSVDVII 151

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1721908663 162 SNGAVNLCPDKKPVLQEAYRVLKEGGELYFSDVYSSGRLTEEIRNSNVLWGECLSGALWWEDLMQLAEEVGFS 234
Cdd:PRK11873  152 SNCVINLSPDKERVFKEAFRVLKPGGRFAISDVVLRGELPEEIRNDAELYAGCVAGALQEEEYLAMLAEAGFV 224
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 78-232 3.34e-34

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 123.68  E-value: 3.34e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663  78 EACQVLDLGSGSGRDCYMLSKLVGEKGNVTGIDMTEKLLEVARTytdyHTQAFGYKapNIRFVQGYLEALnEAGIEGSAY 157
Cdd:pfam13847   3 KGMRVLDLGCGTGHLSFELAEELGPNAEVVGIDISEEAIEKARE----NAQKLGFD--NVEFEQGDIEEL-PELLEDDKF 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1721908663 158 DICISNGAVNLCPDKKPVLQEAYRVLKEGGELYFSDVYSSGRLTEEIRNSNVLWGECLSGALWWEDLMQLAEEVG 232
Cdd:pfam13847  76 DVVISNCVLNHIPDPDKVLQEILRVLKPGGRLIISDPDSLAELPAHVKEDSTYYAGCVGGAILKKKLYELLEEAG 150
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 82-193 5.14e-22

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 90.82  E-value: 5.14e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663  82 VLDLGSGSGRDCYMLSKLVGEkgnVTGIDMTEKLLEVARtytdyhtQAFGYKAPNIRFVQGYLEALneaGIEGSAYDICI 161
Cdd:COG2226    26 VLDLGCGTGRLALALAERGAR---VTGVDISPEMLELAR-------ERAAEAGLNVEFVVGDAEDL---PFPDGSFDLVI 92

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1721908663 162 SNGAVNLCPDKKPVLQEAYRVLKEGGELYFSD 193
Cdd:COG2226    93 SSFVLHHLPDPERALAEIARVLKPGGRLVVVD 124
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 82-195 4.23e-15

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 70.54  E-value: 4.23e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663  82 VLDLGSGSGRDCYMLSKlvGEKGNVTGIDMTEKLLEVARTytdyhtQAFGYKAPNIRFVQGYLEALNEAGIEgsAYDICI 161
Cdd:cd02440     2 VLDLGCGTGALALALAS--GPGARVTGVDISPVALELARK------AAAALLADNVEVLKGDAEELPPEADE--SFDVII 71

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1721908663 162 SNGAVN-LCPDKKPVLQEAYRVLKEGGELYFSDVY 195
Cdd:cd02440    72 SDPPLHhLVEDLARFLEEARRLLKPGGVLVLTLVL 106
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 82-207 7.52e-11

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 61.53  E-value: 7.52e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663  82 VLDLGSGSGrdcyMLSKLV---GEKGNVTGIDMTEKLLEVARTYTdyhtqafgykAPNIRFVQGYLEALNeagIEGSAYD 158
Cdd:TIGR02072  38 VLDIGCGTG----YLTRALlkrFPQAEFIALDISAGMLAQAKTKL----------SENVQFICGDAEKLP---LEDSSFD 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1721908663 159 ICISNGAVNLCPDKKPVLQEAYRVLKEGGELYFSDvYSSGRLtEEIRNS 207
Cdd:TIGR02072 101 LIVSNLALQWCDDLSQALSELARVLKPGGLLAFST-FGPGTL-HELRQS 147
 
Name Accession Description Interval E-value
arsM PRK11873
arsenite methyltransferase;
82-234 3.45e-39

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 140.47  E-value: 3.45e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663  82 VLDLGSGSGRDCYMLSKLVGEKGNVTGIDMTEKLLEVARTytdyhtQAFGYKAPNIRFVQGYLEALNeagIEGSAYDICI 161
Cdd:PRK11873   81 VLDLGSGGGFDCFLAARRVGPTGKVIGVDMTPEMLAKARA------NARKAGYTNVEFRLGEIEALP---VADNSVDVII 151

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1721908663 162 SNGAVNLCPDKKPVLQEAYRVLKEGGELYFSDVYSSGRLTEEIRNSNVLWGECLSGALWWEDLMQLAEEVGFS 234
Cdd:PRK11873  152 SNCVINLSPDKERVFKEAFRVLKPGGRFAISDVVLRGELPEEIRNDAELYAGCVAGALQEEEYLAMLAEAGFV 224
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 78-232 3.34e-34

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 123.68  E-value: 3.34e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663  78 EACQVLDLGSGSGRDCYMLSKLVGEKGNVTGIDMTEKLLEVARTytdyHTQAFGYKapNIRFVQGYLEALnEAGIEGSAY 157
Cdd:pfam13847   3 KGMRVLDLGCGTGHLSFELAEELGPNAEVVGIDISEEAIEKARE----NAQKLGFD--NVEFEQGDIEEL-PELLEDDKF 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1721908663 158 DICISNGAVNLCPDKKPVLQEAYRVLKEGGELYFSDVYSSGRLTEEIRNSNVLWGECLSGALWWEDLMQLAEEVG 232
Cdd:pfam13847  76 DVVISNCVLNHIPDPDKVLQEILRVLKPGGRLIISDPDSLAELPAHVKEDSTYYAGCVGGAILKKKLYELLEEAG 150
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 82-193 5.14e-22

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 90.82  E-value: 5.14e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663  82 VLDLGSGSGRDCYMLSKLVGEkgnVTGIDMTEKLLEVARtytdyhtQAFGYKAPNIRFVQGYLEALneaGIEGSAYDICI 161
Cdd:COG2226    26 VLDLGCGTGRLALALAERGAR---VTGVDISPEMLELAR-------ERAAEAGLNVEFVVGDAEDL---PFPDGSFDLVI 92

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1721908663 162 SNGAVNLCPDKKPVLQEAYRVLKEGGELYFSD 193
Cdd:COG2226    93 SSFVLHHLPDPERALAEIARVLKPGGRLVVVD 124
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 82-187 1.58e-21

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 88.00  E-value: 1.58e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663  82 VLDLGSGSGRDCYMLSKLVGekGNVTGIDMTEKLLEVARtytdyhtQAFGYKAPNIRFVQGYLEALNEagiEGSAYDICI 161
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGG--ARVTGVDLSPEMLERAR-------ERAAEAGLNVEFVQGDAEDLPF---PDGSFDLVV 68

                          90       100
                  ....*....|....*....|....*...
gi 1721908663 162 SNGAVNLC--PDKKPVLQEAYRVLKEGG 187
Cdd:pfam13649  69 SSGVLHHLpdPDLEAALREIARVLKPGG 96
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 82-193 3.55e-18

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 79.68  E-value: 3.55e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663  82 VLDLGSGSGRDCYMLSKLvgekG-NVTGIDMTEKLLEVARTYtdyhtqafgYKAPNIRFVQGYLEALNeagIEGSAYDIC 160
Cdd:COG2227    28 VLDVGCGTGRLALALARR----GaDVTGVDISPEALEIARER---------AAELNVDFVQGDLEDLP---LEDGSFDLV 91

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1721908663 161 ISNGAVNLCPDKKPVLQEAYRVLKEGGELYFSD 193
Cdd:COG2227    92 ICSEVLEHLPDPAALLRELARLLKPGGLLLLST 124
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 83-191 2.68e-15

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 70.77  E-value: 2.68e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663  83 LDLGSGSGRDCYMLSKLVGekgNVTGIDMTEKLLEVARTYtdyhtqafgYKAPNIRFVQGYLEALneaGIEGSAYDICIS 162
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGA---RVTGVDISPEMLELAREK---------APREGLTFVVGDAEDL---PFPDNSFDLVLS 65

                          90       100
                  ....*....|....*....|....*....
gi 1721908663 163 NGAVNLCPDKKPVLQEAYRVLKEGGELYF 191
Cdd:pfam08241  66 SEVLHHVEDPERALREIARVLKPGGILII 94
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 82-195 4.23e-15

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 70.54  E-value: 4.23e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663  82 VLDLGSGSGRDCYMLSKlvGEKGNVTGIDMTEKLLEVARTytdyhtQAFGYKAPNIRFVQGYLEALNEAGIEgsAYDICI 161
Cdd:cd02440     2 VLDLGCGTGALALALAS--GPGARVTGVDISPVALELARK------AAAALLADNVEVLKGDAEELPPEADE--SFDVII 71

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1721908663 162 SNGAVN-LCPDKKPVLQEAYRVLKEGGELYFSDVY 195
Cdd:cd02440    72 SDPPLHhLVEDLARFLEEARRLLKPGGVLVLTLVL 106
PRK08317 PRK08317
hypothetical protein; Provisional
 81-187 3.07e-13

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 68.81  E-value: 3.07e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663  81 QVLDLGSGSGRDCYMLSKLVGEKGNVTGIDMTEKLLEVARTYTDYHTqafgykaPNIRFVQGYLEALneaGIEGSAYDIC 160
Cdd:PRK08317   22 RVLDVGCGPGNDARELARRVGPEGRVVGIDRSEAMLALAKERAAGLG-------PNVEFVRGDADGL---PFPDGSFDAV 91

                          90       100
                  ....*....|....*....|....*..
gi 1721908663 161 ISNGAVNLCPDKKPVLQEAYRVLKEGG 187
Cdd:PRK08317   92 RSDRVLQHLEDPARALAEIARVLRPGG 118
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 81-238 4.38e-13

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 68.26  E-value: 4.38e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663  81 QVLDLGSGSGRDCYMLSKLVGEKGNVTGIDMTEKLLEVARtytDYHTQAfgYKAPNIRFVQGYLEALneaGIEGSAYD-I 159
Cdd:PRK00216   54 KVLDLACGTGDLAIALAKAVGKTGEVVGLDFSEGMLAVGR---EKLRDL--GLSGNVEFVQGDAEAL---PFPDNSFDaV 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663 160 CISNGAVNLcPDKKPVLQEAYRVLKEGGE---LYFS-----------DVYSS------GR-----------LTEEIRNsn 208
Cdd:PRK00216  126 TIAFGLRNV-PDIDKALREMYRVLKPGGRlviLEFSkptnpplkkayDFYLFkvlpliGKlisknaeaysyLAESIRA-- 202

                         170       180       190
                  ....*....|....*....|....*....|
gi 1721908663 209 vlWgecLSGalwwEDLMQLAEEVGFSPPRF 238
Cdd:PRK00216  203 --F---PDQ----EELAAMLEEAGFERVRY 223
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
81-193 2.80e-12

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 62.53  E-value: 2.80e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663  81 QVLDLGSGSGRDCYMLSKLVGEkGNVTGIDMTEKLLEVARTytdyhtqafgyKAPNIRFVQGYLEALNEAGiegsAYDIC 160
Cdd:COG4106     4 RVLDLGCGTGRLTALLAERFPG-ARVTGVDLSPEMLARARA-----------RLPNVRFVVADLRDLDPPE----PFDLV 67

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1721908663 161 ISNGAVNLCPDKKPVLQEAYRVLKEGGELYFSD 193
Cdd:COG4106    68 VSNAALHWLPDHAALLARLAAALAPGGVLAVQV 100
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
82-190 3.23e-12

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 65.54  E-value: 3.23e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663  82 VLDLGSGSGRDCYMLSKLVGEKGNVTGIDMTEKLLEVARTytdyHTQAFGYKapNIRFVQGYLEALNEagIEGSAYDICI 161
Cdd:pfam01209  46 FLDVAGGTGDWTFGLSDSAGSSGKVVGLDINENMLKEGEK----KAKEEGKY--NIEFLQGNAEELPF--EDDSFDIVTI 117

                          90       100
                  ....*....|....*....|....*....
gi 1721908663 162 SNGAVNLcPDKKPVLQEAYRVLKEGGELY 190
Cdd:pfam01209 118 SFGLRNF-PDYLKVLKEAFRVLKPGGRVV 145
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
82-239 3.99e-12

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 64.25  E-value: 3.99e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663  82 VLDLGSGSGRDCYMLSKLVGEkgnVTGIDMTEKLLEVARTytdyhtqafgyKAPNIRFVQGYLEALNEagiEGSAYDICI 161
Cdd:COG4976    50 VLDLGCGTGLLGEALRPRGYR---LTGVDLSEEMLAKARE-----------KGVYDRLLVADLADLAE---PDGRFDLIV 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663 162 SNGAVNLCPDKKPVLQEAYRVLKEGGELYFS--DVYSSGRlteeirnsnvlwgeclsGALWWEDLMQLAEEVGFSPPRFV 239
Cdd:COG4976   113 AADVLTYLGDLAAVFAGVARALKPGGLFIFSveDADGSGR-----------------YAHSLDYVRDLLAAAGFEVPGLL 175
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 71-247 5.65e-12

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 64.17  E-value: 5.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663  71 LVVPECMEACQVLDLGSGSGRDCYMLSKLVGekGNVTGIDMTEKLLEVARTytdyhtQAFGYKAPNIRFVQGylEALNEA 150
Cdd:COG0500    19 ALLERLPKGGRVLDLGCGTGRNLLALAARFG--GRVIGIDLSPEAIALARA------RAAKAGLGNVEFLVA--DLAELD 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663 151 GIEGSAYDICISNGAVNLCPDKK--PVLQEAYRVLKEGGELYFSDVYSSGRLTEEIRnsnvlwgECLSGALWWEDLMQLA 228
Cdd:COG0500    89 PLPAESFDLVVAFGVLHHLPPEEreALLRELARALKPGGVLLLSASDAAAALSLARL-------LLLATASLLELLLLLR 161

                         170
                  ....*....|....*....
gi 1721908663 229 EEVGFSPPRFVSGAAIKVF 247
Cdd:COG0500   162 LLALELYLRALLAAAATED 180
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 82-207 7.52e-11

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 61.53  E-value: 7.52e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663  82 VLDLGSGSGrdcyMLSKLV---GEKGNVTGIDMTEKLLEVARTYTdyhtqafgykAPNIRFVQGYLEALNeagIEGSAYD 158
Cdd:TIGR02072  38 VLDIGCGTG----YLTRALlkrFPQAEFIALDISAGMLAQAKTKL----------SENVQFICGDAEKLP---LEDSSFD 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1721908663 159 ICISNGAVNLCPDKKPVLQEAYRVLKEGGELYFSDvYSSGRLtEEIRNS 207
Cdd:TIGR02072 101 LIVSNLALQWCDDLSQALSELARVLKPGGLLAFST-FGPGTL-HELRQS 147
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 83-189 9.66e-09

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 52.37  E-value: 9.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663  83 LDLGSGSGRDCYMLSKLVGEkGNVTGIDMTEKLLEVARTYTDyhtqafGYKAPNIRFVQgyLEALNEAGIEGSAYDICIS 162
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPG-LEYTGLDISPAALEAARERLA------ALGLLNAVRVE--LFQLDLGELDPGSFDVVVA 71

                          90       100
                  ....*....|....*....|....*..
gi 1721908663 163 NGAVNLCPDKKPVLQEAYRVLKEGGEL 189
Cdd:pfam08242  72 SNVLHHLADPRAVLRNIRRLLKPGGVL 98
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 81-192 2.58e-07

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 51.30  E-value: 2.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663  81 QVLDLGSGSGRdcymLSKLVGEKG-NVTGIDMTEKLLEVARTYTDYHtqafgykapniRFVQGYLEALNEAgiEGSaYDI 159
Cdd:PRK10258   45 HVLDAGCGPGW----MSRYWRERGsQVTALDLSPPMLAQARQKDAAD-----------HYLAGDIESLPLA--TAT-FDL 106

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1721908663 160 CISNGAVNLCPDKKPVLQEAYRVLKEGGELYFS 192
Cdd:PRK10258  107 AWSNLAVQWCGNLSTALRELYRVVRPGGVVAFT 139
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 82-193 5.04e-05

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 42.99  E-value: 5.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663  82 VLDLGSGSGRDCYMLSKLVGekGNVTGIDMTEKLLEVARTytdyHTQAFGyKAPNIRFVQGYLEALNEAGiegsAYDICI 161
Cdd:COG2230    55 VLDIGCGWGGLALYLARRYG--VRVTGVTLSPEQLEYARE----RAAEAG-LADRVEVRLADYRDLPADG----QFDAIV 123

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1721908663 162 SNGAVNLCPDKK--PVLQEAYRVLKEGGELYFSD 193
Cdd:COG2230   124 SIGMFEHVGPENypAYFAKVARLLKPGGRLLLHT 157
PLN02233 PLN02233
ubiquinone biosynthesis methyltransferase
 82-234 1.47e-04

ubiquinone biosynthesis methyltransferase


Pssm-ID: 177877 [Multi-domain]  Cd Length: 261  Bit Score: 42.96  E-value: 1.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663  82 VLDLGSGSGRDCYMLSKLVGEKGNVTGIDMTEKLLEVARTYTDYHTQAfGYKapNIRFVQGylEALNEAGIEGSAYDICI 161
Cdd:PLN02233   77 VLDLCCGSGDLAFLLSEKVGSDGKVMGLDFSSEQLAVAASRQELKAKS-CYK--NIEWIEG--DATDLPFDDCYFDAITM 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663 162 SNGAVNLCpDKKPVLQEAYRVLKEGGELYFSDVYSSGR-----------------------LTEEIRNSNVLWGECLSGa 218
Cdd:PLN02233  152 GYGLRNVV-DRLKAMQEMYRVLKPGSRVSILDFNKSTQpfttsmqewmidnvvvpvatgygLAKEYEYLKSSINEYLTG- 229

                         170
                  ....*....|....*.
gi 1721908663 219 lwwEDLMQLAEEVGFS 234
Cdd:PLN02233  230 ---EELEKLALEAGFS 242
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 82-240 1.51e-04

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 42.09  E-value: 1.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663  82 VLDLGSGSGRDCYMLSKLVGEKGNVTGIDMTEKLLEVARTYtdyhTQAFGYkAPNIRFVQGY-LEALneAGIEGSAYDIC 160
Cdd:COG4122    20 ILEIGTGTGYSTLWLARALPDDGRLTTIEIDPERAAIAREN----FARAGL-ADRIRLILGDaLEVL--PRLADGPFDLV 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663 161 ISNGAVNLCPDkkpVLQEAYRVLKEGGELYFSDVYSSGRLTEEIRNSNVlwgeclsgalwWEDLMQLAEEVgFSPPRFVS 240
Cdd:COG4122    93 FIDADKSNYPD---YLELALPLLRPGGLIVADNVLWHGRVADPARRDPS-----------TRAIREFNEYL-REDPRLES 157
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
82-189 1.96e-04

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 41.97  E-value: 1.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663  82 VLDLGSGSGRDCYMLSKLVGEKGNVTGIDMTEKLLEVARTytdyHTQAFGYKAPNIRFVQGYLealneaGIEGSA-YDIC 160
Cdd:pfam01135  77 VLEIGSGSGYLTACFARMVGEVGRVVSIEHIPELVEIARR----NLEKLGLENVIVVVGDGRQ------GWPEFApYDAI 146

                          90       100
                  ....*....|....*....|....*....
gi 1721908663 161 IsngaVNLCPDKKPvlQEAYRVLKEGGEL 189
Cdd:pfam01135 147 H----VGAAAPEIP--EALIDQLKEGGRL 169
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 82-187 6.64e-04

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 40.91  E-value: 6.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663  82 VLDLGSGSGRDCYMLSKLVGEKGNVTGIDMTEKLLEVARTytdyHTQAFGyKAPNIRFVQGYLealnEAGIEGSAYDici 161
Cdd:COG2519    95 VLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARK----NLERFG-LPDNVELKLGDI----REGIDEGDVD--- 162

                          90       100
                  ....*....|....*....|....*..
gi 1721908663 162 sngAVNL-CPDKKPVLQEAYRVLKEGG 187
Cdd:COG2519   163 ---AVFLdMPDPWEALEAVAKALKPGG 186
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 82-187 6.93e-04

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 40.46  E-value: 6.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663  82 VLDLGSGSGrdcYM---LSKLVGEkgnVTGIDMTEKLLEVARTytdyHTQAFGYkaPNIRFVQGylealneAGIEGSA-- 156
Cdd:COG2518    70 VLEIGTGSG---YQaavLARLAGR---VYSVERDPELAERARE----RLAALGY--DNVTVRVG-------DGALGWPeh 130

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1721908663 157 --YDICISNGAVnlcPDKKPVLQEAyrvLKEGG 187
Cdd:COG2518   131 apFDRIIVTAAA---PEVPEALLEQ---LAPGG 157
PLN02490 PLN02490
MPBQ/MSBQ methyltransferase
 82-187 6.99e-04

MPBQ/MSBQ methyltransferase


Pssm-ID: 215270 [Multi-domain]  Cd Length: 340  Bit Score: 41.42  E-value: 6.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663  82 VLDLGSGSGRDCYMLSKLVGEKgNVTGIDMTEKLLEVARTytdyhtqafgyKAP--NIRFVQGYLEALNeagIEGSAYDI 159
Cdd:PLN02490  117 VVDVGGGTGFTTLGIVKHVDAK-NVTILDQSPHQLAKAKQ-----------KEPlkECKIIEGDAEDLP---FPTDYADR 181

                          90       100
                  ....*....|....*....|....*...
gi 1721908663 160 CISNGAVNLCPDKKPVLQEAYRVLKEGG 187
Cdd:PLN02490  182 YVSAGSIEYWPDPQRGIKEAYRVLKIGG 209
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 82-237 1.95e-03

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 39.36  E-value: 1.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663  82 VLDLGSGSGRDCYMLSKLVgEKGNVTGIDMTEKLLEVARtytdyhtQAFGY--KAPNIRFVQGYLEALNEAGIEGSaYDI 159
Cdd:COG4123    41 VLDLGTGTGVIALMLAQRS-PGARITGVEIQPEAAELAR-------RNVALngLEDRITVIHGDLKEFAAELPPGS-FDL 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663 160 CISN------GAVNLCPDKK-------------PVLQEAYRVLKEGGELYFsdVYSSGRLteeirnsnvlwgeclsgalw 220
Cdd:COG4123   112 VVSNppyfkaGSGRKSPDEAraiarhedaltleDLIRAAARLLKPGGRFAL--IHPAERL-------------------- 169

                         170
                  ....*....|....*..
gi 1721908663 221 wEDLMQLAEEVGFSPPR 237
Cdd:COG4123   170 -AEILAALRKYGLGPKR 185
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 82-191 2.73e-03

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 38.99  E-value: 2.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663  82 VLDLGSGSGrdCYMLS-KLVGEKGNVTGIDMTEKLLEVARTYTDYHtqafgyKAPNIRFVQG-YLEALNEAGiegsaYDI 159
Cdd:TIGR03534  90 VLDLGTGSG--AIALAlAKERPDARVTAVDISPEALAVARKNARRL------GLENVEFLQGdWFEPLPSGK-----FDL 156

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663 160 CISN----------------------GAvnLCPDK------KPVLQEAYRVLKEGGELYF 191
Cdd:TIGR03534 157 IVSNppyipeadihlldpevrdfeprLA--LFGGEdgldfyRRIIAQAPRLLKPGGWLLL 214
PRK13943 PRK13943
protein-L-isoaspartate O-methyltransferase; Provisional
 78-120 3.16e-03

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 237568 [Multi-domain]  Cd Length: 322  Bit Score: 39.06  E-value: 3.16e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1721908663  78 EACQVLDLGSGSGRDCYMLSKLVGEKGNVTGIDMTEKLLEVAR 120
Cdd:PRK13943   80 KGMRVLEIGGGTGYNAAVMSRVVGEKGLVVSVEYSRKICEIAK 122
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 78-163 4.64e-03

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 38.60  E-value: 4.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663  78 EACQVLDLGSGSGrdCYMLSkLVGEKGN--VTGIDMTEKLLEVARTYTDYHTQAfgykapNIRFVQG-YLEALneagiEG 154
Cdd:PRK09328  108 EPLRVLDLGTGSG--AIALA-LAKERPDaeVTAVDISPEALAVARRNAKHGLGA------RVEFLQGdWFEPL-----PG 173


                  ....*....
gi 1721908663 155 SAYDICISN 163
Cdd:PRK09328  174 GRFDLIVSN 182
PRK12335 PRK12335
tellurite resistance protein TehB; Provisional
 55-162 7.80e-03

tellurite resistance protein TehB; Provisional


Pssm-ID: 183450 [Multi-domain]  Cd Length: 287  Bit Score: 37.62  E-value: 7.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721908663  55 LNMVHPEVIAKYygcglvvpECMEACQVLDLGSGSGRDCYMLSKlvgeKG-NVTGIDMTE----KLLEVARTyTDYHTQA 129
Cdd:PRK12335  105 LTATHSEVLEAV--------QTVKPGKALDLGCGQGRNSLYLAL----LGfDVTAVDINQqsleNLQEIAEK-ENLNIRT 171

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1721908663 130 FGYKapnirfvqgyleaLNEAGIEGsAYDICIS 162
Cdd:PRK12335  172 GLYD-------------INSASIQE-EYDFILS 190
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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